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< em > Panax notoginseng < /em > Saponins Activate Nuclear Factor Erythroid 2-Related Factor 2 to Inhibit Ferroptosis and Attenuate Inflammatory Injury in Cerebral Ischemia-Reperfusion
In this study, we aimed to investigate the effects of PNS on ferroptosis and inflammation in CIRI. We induced ferroptosis in SH-SY5Y cells via erastin stimulation and oxygen glucose deprivation/re-oxygenation (OGD/R) in vitro. Furthermore, we determined the effect of PNS treatment in a rat model of middle cerebral artery occlusion/reperfusion and assessed the underlying mechanism. We also analyzed the changes in the expression of ferroptosis-related proteins and inflammatory factors in the established rat model. OGD/R led to an increase in the levels of ferroptosis markers in SH-SY5Y cells, which were reduced by PNS treatm...
Source: The American Journal of Chinese Medicine - May 3, 2024 Category: Complementary Medicine Authors: Lin-Lin Wang Man-Lin Kang Can-Wen Liu Liang Liu Biao Tang Source Type: research

< em > Ginkgo biloba < /em > and Its Chemical Components in the Management of Alzheimer's Disease
Am J Chin Med. 2024 Apr 24:1-42. doi: 10.1142/S0192415X24500277. Online ahead of print.ABSTRACTThe pathogenesis of Alzheimer's disease (AD), a degenerative disease of the central nervous system, remains unclear. The main manifestations of AD include cognitive and behavioral disorders, neuropsychiatric symptoms, neuroinflammation, amyloid plaques, and neurofibrillary tangles. However, current drugs for AD once the dementia stage has been reached only treat symptoms and do not delay progression, and the research and development of targeted drugs for AD have reached a bottleneck. Thus, other treatment options are needed. Bioa...
Source: The American Journal of Chinese Medicine - April 24, 2024 Category: Complementary Medicine Authors: Yong Peng Quan Chen Ya-Hui Xue Hong Jin Shu Liu Miao-Qiao Du Shun-Yu Yao Source Type: research

Ginsenoside Rd Attenuates Myocardial Ischemia/Reperfusion Injury by Inhibiting Inflammation and Apoptosis through PI3K/Akt Signaling Pathway
This study investigated GRd as a potent therapeutic agent for myocardial I/R injury. Oxygen-glucose deprivation and reperfusion (OGD/R) and left anterior descending (LAD) coronary artery ligation were used to establish a myocardial I/R injury model in vitro and in vivo. In vivo, GRd significantly reduced the myocardial infarct size and markers of myocardial injury and improved the cardiac function in myocardial I/R injury mice. In vitro, GRd enhanced cell viability and protected the H9c2 rat cardiomyoblast cell line from OGD-induced injury GRd. The network pharmacology analysis predicted 48 potential targets of GRd for the...
Source: The American Journal of Chinese Medicine - April 5, 2024 Category: Complementary Medicine Authors: Yuanping Wang Jiading Zheng Xieyang Xiao Cailing Feng Yinghong Li Hui Su Ding Yuan Qinghai Wang Peihong Huang Lili Jin Source Type: research