Association of Lower Rostral Anterior Cingulate GABA+ and Dysregulated Cortisol Stress Response With Altered Functional Connectivity in Young Adults With Lifetime Depression: A Multimodal Imaging Investigation of Trait and State Effects
CONCLUSIONS: Lifetime MDD was characterized by reduced rACC GABA+ as well as dysregulated cortisol-related interactions between top-down control (frontoparietal) and threat (task-related) networks. These findings warrant further investigation of the role of GABA in the vulnerability to and treatment of MDD.PMID:38685857 | DOI:10.1176/appi.ajp.20230382 (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 30, 2024 Category: Psychiatry Authors: Maria Ironside Jessica M Duda Amelia D Moser Laura M Holsen Chun S Zuo Fei Du Sarah Perlo Christine E Richards Xi Chen Lisa D Nickerson Kaylee E Null Shiba M Esfand Madeline M Alexander David J Crowley Meghan Lauze Madhusmita Misra Jill M Goldstein Diego Source Type: research
Shared and Specific Neural Correlates of Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder: A Meta-Analysis of 243 Task-Based Functional MRI Studies
CONCLUSIONS: Although ASD and ADHD showed both shared and disorder-specific standardized neural activations, disorder-specific activations were more prominent than shared ones. Functional brain differences between ADHD and ASD are more likely to reflect diagnosis-related pathophysiology than bias from the selection of specific neuropsychological tasks.PMID:38685858 | DOI:10.1176/appi.ajp.20230270 (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 30, 2024 Category: Psychiatry Authors: Hiroki Tamon Junya Fujino Takashi Itahashi Lennart Frahm Valeria Parlatini Yuta Y Aoki Francisco Xavier Castellanos Simon B Eickhoff Samuele Cortese Source Type: research
Pharmacogenomic Clinical Support Tools for the Treatment of Depression
CONCLUSIONS: The addition of these new data do not alter the recommendations of the 2018 report, or the advice of the U.S. Food and Drug Administration, that the evidence does not support the use of currently available combinatorial PGx tools for treatment selection in major depressive disorder. Priority efforts for future studies and the development and testing of effective tools include fully blinded study designs, inclusion of promising genetic variants not currently included in any commercially available tests, and investigation of other uses of pharmacogenomics, such as estimating the likelihood of rare adverse drug e...
Source: The American Journal of Psychiatry - April 30, 2024 Category: Psychiatry Authors: Matthew L Baum Alik S Widge Linda L Carpenter William M McDonald Bruce M Cohen Charles B Nemeroff American Psychiatric Association (APA) Workgroup on Biomarkers and Novel Treatments Source Type: research
Association of Lower Rostral Anterior Cingulate GABA+ and Dysregulated Cortisol Stress Response With Altered Functional Connectivity in Young Adults With Lifetime Depression: A Multimodal Imaging Investigation of Trait and State Effects
CONCLUSIONS: Lifetime MDD was characterized by reduced rACC GABA+ as well as dysregulated cortisol-related interactions between top-down control (frontoparietal) and threat (task-related) networks. These findings warrant further investigation of the role of GABA in the vulnerability to and treatment of MDD.PMID:38685857 | DOI:10.1176/appi.ajp.20230382 (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 30, 2024 Category: Psychiatry Authors: Maria Ironside Jessica M Duda Amelia D Moser Laura M Holsen Chun S Zuo Fei Du Sarah Perlo Christine E Richards Xi Chen Lisa D Nickerson Kaylee E Null Shiba M Esfand Madeline M Alexander David J Crowley Meghan Lauze Madhusmita Misra Jill M Goldstein Diego Source Type: research
Shared and Specific Neural Correlates of Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder: A Meta-Analysis of 243 Task-Based Functional MRI Studies
CONCLUSIONS: Although ASD and ADHD showed both shared and disorder-specific standardized neural activations, disorder-specific activations were more prominent than shared ones. Functional brain differences between ADHD and ASD are more likely to reflect diagnosis-related pathophysiology than bias from the selection of specific neuropsychological tasks.PMID:38685858 | DOI:10.1176/appi.ajp.20230270 (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 30, 2024 Category: Psychiatry Authors: Hiroki Tamon Junya Fujino Takashi Itahashi Lennart Frahm Valeria Parlatini Yuta Y Aoki Francisco Xavier Castellanos Simon B Eickhoff Samuele Cortese Source Type: research
Pharmacogenomic Clinical Support Tools for the Treatment of Depression
CONCLUSIONS: The addition of these new data do not alter the recommendations of the 2018 report, or the advice of the U.S. Food and Drug Administration, that the evidence does not support the use of currently available combinatorial PGx tools for treatment selection in major depressive disorder. Priority efforts for future studies and the development and testing of effective tools include fully blinded study designs, inclusion of promising genetic variants not currently included in any commercially available tests, and investigation of other uses of pharmacogenomics, such as estimating the likelihood of rare adverse drug e...
Source: The American Journal of Psychiatry - April 30, 2024 Category: Psychiatry Authors: Matthew L Baum Alik S Widge Linda L Carpenter William M McDonald Bruce M Cohen Charles B Nemeroff American Psychiatric Association (APA) Workgroup on Biomarkers and Novel Treatments Source Type: research
Association of Lower Rostral Anterior Cingulate GABA+ and Dysregulated Cortisol Stress Response With Altered Functional Connectivity in Young Adults With Lifetime Depression: A Multimodal Imaging Investigation of Trait and State Effects
CONCLUSIONS: Lifetime MDD was characterized by reduced rACC GABA+ as well as dysregulated cortisol-related interactions between top-down control (frontoparietal) and threat (task-related) networks. These findings warrant further investigation of the role of GABA in the vulnerability to and treatment of MDD.PMID:38685857 | DOI:10.1176/appi.ajp.20230382 (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 30, 2024 Category: Psychiatry Authors: Maria Ironside Jessica M Duda Amelia D Moser Laura M Holsen Chun S Zuo Fei Du Sarah Perlo Christine E Richards Xi Chen Lisa D Nickerson Kaylee E Null Shiba M Esfand Madeline M Alexander David J Crowley Meghan Lauze Madhusmita Misra Jill M Goldstein Diego Source Type: research
Shared and Specific Neural Correlates of Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder: A Meta-Analysis of 243 Task-Based Functional MRI Studies
CONCLUSIONS: Although ASD and ADHD showed both shared and disorder-specific standardized neural activations, disorder-specific activations were more prominent than shared ones. Functional brain differences between ADHD and ASD are more likely to reflect diagnosis-related pathophysiology than bias from the selection of specific neuropsychological tasks.PMID:38685858 | DOI:10.1176/appi.ajp.20230270 (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 30, 2024 Category: Psychiatry Authors: Hiroki Tamon Junya Fujino Takashi Itahashi Lennart Frahm Valeria Parlatini Yuta Y Aoki Francisco Xavier Castellanos Simon B Eickhoff Samuele Cortese Source Type: research
Pharmacogenomic Clinical Support Tools for the Treatment of Depression
CONCLUSIONS: The addition of these new data do not alter the recommendations of the 2018 report, or the advice of the U.S. Food and Drug Administration, that the evidence does not support the use of currently available combinatorial PGx tools for treatment selection in major depressive disorder. Priority efforts for future studies and the development and testing of effective tools include fully blinded study designs, inclusion of promising genetic variants not currently included in any commercially available tests, and investigation of other uses of pharmacogenomics, such as estimating the likelihood of rare adverse drug e...
Source: The American Journal of Psychiatry - April 30, 2024 Category: Psychiatry Authors: Matthew L Baum Alik S Widge Linda L Carpenter William M McDonald Bruce M Cohen Charles B Nemeroff American Psychiatric Association (APA) Workgroup on Biomarkers and Novel Treatments Source Type: research
Neglect of Adverse Effects in Treatment Guidelines for Depression
Am J Psychiatry. 2024 Apr 1;181(4):342-345. doi: 10.1176/appi.ajp.20230553.NO ABSTRACTPMID:38557140 | DOI:10.1176/appi.ajp.20230553 (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2024 Category: Psychiatry Authors: Harish Kavirajan Source Type: research
What Risks Do Offspring of Parents With Alcohol Use Disorder Face?
Am J Psychiatry. 2024 Apr 1;181(4):269-271. doi: 10.1176/appi.ajp.20240097.NO ABSTRACTPMID:38557141 | DOI:10.1176/appi.ajp.20240097 (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2024 Category: Psychiatry Authors: Howard J Edenberg Source Type: research
The Influence of Parenting on Callous-Unemotional Traits and the Implications for the Causes and Treatment of Conduct Disorder
Am J Psychiatry. 2024 Apr 1;181(4):265-268. doi: 10.1176/appi.ajp.20240096.NO ABSTRACTPMID:38557142 | DOI:10.1176/appi.ajp.20240096 (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2024 Category: Psychiatry Authors: Paul J Frick Source Type: research
Gender Differences in the Neurobiology of Childhood Anxiety: The Need for a Developmental Perspective
Am J Psychiatry. 2024 Apr 1;181(4):262-264. doi: 10.1176/appi.ajp.20240124.NO ABSTRACTPMID:38557143 | DOI:10.1176/appi.ajp.20240124 (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2024 Category: Psychiatry Authors: Chad Sylvester Joan Luby Source Type: research
Mechanism-Focused Randomized Controlled Trials in Youths: Another Step Uphill
Am J Psychiatry. 2024 Apr 1;181(4):259-261. doi: 10.1176/appi.ajp.20240123.NO ABSTRACTPMID:38557144 | DOI:10.1176/appi.ajp.20240123 (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2024 Category: Psychiatry Authors: Argyris Stringaris Jamilah Silver Source Type: research
Predicting Conversion to Psychosis: What Lies Beyond the Biomarkers?
Am J Psychiatry. 2024 Apr 1;181(4):272-274. doi: 10.1176/appi.ajp.20240100.NO ABSTRACTPMID:38557145 | DOI:10.1176/appi.ajp.20240100 (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - April 1, 2024 Category: Psychiatry Authors: Gregory A Light Neal R Swerdlow Source Type: research
