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2024 Alzheimer's disease facts and figures
This article describes the public health impact of Alzheimer's disease (AD), including prevalence and incidence, mortality and morbidity, use and costs of care and the ramifications of AD for family caregivers, the dementia workforce and society. The Special Report discusses the larger health care system for older adults with cognitive issues, focusing on the role of caregivers and non-physician health care professionals. An estimated 6.9 million Americans age 65 and older are living with Alzheimer's dementia today. This number could grow to 13.8 million by 2060, barring the development of medical breakthroughs to prevent ...
Source: The Journal of Alzheimers Association - May 1, 2024 Category: Psychiatry Source Type: research

Sleep-wake behavior, perceived fatigability, and cognitive reserve in older adults
DISCUSSION: SRI can amplify impaired cognitive abilities through exacerbation of fatigability in patients with aMCI with below-mean CR. Therefore, improving sleep-wake regulation and leisure activities may protect against fatigability and cognitive decline.HIGHLIGHTS: Clinical fatigue and fatigability cannot be alleviated by rest. Clinical fatigability disrupts daily activities during preclinical Alzheimer's. High cognitive reserve mitigates sleep-wake disturbance effects. High cognitive reserve attenuates clinical fatigability effects on daily functioning. Untreated obstructive sleep apnea potentiates Alzheimer's patholog...
Source: The Journal of Alzheimers Association - May 1, 2024 Category: Psychiatry Authors: Nancy Kerner Terry E Goldberg Hannah R Cohen Julia G Phillips Daniel E Cohen Howard Andrews Gregory Pelton Davangere P Devanand Source Type: research

Experimental laboratory models as tools for understanding modifiable dementia risk
Alzheimers Dement. 2024 Apr 30. doi: 10.1002/alz.13834. Online ahead of print.ABSTRACTExperimental laboratory research has an important role to play in dementia prevention. Mechanisms underlying modifiable risk factors for dementia are promising targets for dementia prevention but are difficult to investigate in human populations due to technological constraints and confounds. Therefore, controlled laboratory experiments in models such as transgenic rodents, invertebrates and in vitro cultured cells are increasingly used to investigate dementia risk factors and test strategies which target them to prevent dementia. This re...
Source: The Journal of Alzheimers Association - April 30, 2024 Category: Psychiatry Authors: Duncan Sinclair Alison J Canty Jenna M Ziebell Adele Woodhouse Jessica M Collins Sharn Perry Eddy Roccati Maneesh Kuruvilla Jacqueline Leung Rachel Atkinson James C Vickers Anthony L Cook Anna E King Source Type: research

In vivo validation of late-onset Alzheimer's disease genetic risk factors
DISCUSSION: These results provide an initial functionalization of 11 candidate risk variants and identify potential preclinical models for testing targeted therapeutics.HIGHLIGHTS: A novel approach to validate genetic risk factors for late-onset AD (LOAD) is presented. LOAD risk variants were knocked in to conserved mouse loci. Variant effects were assayed by transcriptional analysis. Risk variants in Abca7, Mthfr, Plcg2, and Sorl1 loci modeled molecular signatures of clinical disease. This approach should generate more translationally relevant animal models.PMID:38687251 | DOI:10.1002/alz.13840 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 30, 2024 Category: Psychiatry Authors: Michael Sasner Christoph Preuss Ravi S Pandey Asli Uyar Dylan Garceau Kevin P Kotredes Harriet Williams Adrian L Oblak Peter Bor-Chian Lin Bridget Perkins Disha Soni Cindy Ingraham Audrey Lee-Gosselin Bruce T Lamb Gareth R Howell Gregory W Carter Source Type: research

Biomarkers - Part 1
CONCLUSION: While not as robust as CSF ratios, plasma Aβ42/Aβ40 and Aβ42/tau ratios can isolate cognitively healthy participants with lower risk from participants with a higher risk of cognitive decline. Thus, plasma represents a less invasive medium for the biomarker classification of aging participants.PMID:38687559 | DOI:10.1002/alz.079861 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 30, 2024 Category: Psychiatry Authors: Alfred N Fonteh Xiaomeng Wu Natalie Astraea Tamara Elenberger David P Buennagel Caleb Sin Mitchell Spezzaferri Shant Rising Anne Nolty Helena C Chui Yafa Minazad Robert A Kloner Xianghong Arakaki Source Type: research

Data-driven decomposition and staging of flortaucipir uptake in Alzheimer's disease
DISCUSSION: Data-driven decomposition of flortaucipir uptake provides a novel framework for tau staging which complements existing systems.HIGHLIGHTS: NMF reveals patterns of tau deposition in AD. Data-driven staging of flortaucipir tracks AD severity. Learned flortaucipir patterns overlap with AD-related gene expression.PMID:38683905 | DOI:10.1002/alz.13769 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 29, 2024 Category: Psychiatry Authors: Tom Earnest Abdalla Bani Sung Min Ha Diana A Hobbs Deydeep Kothapalli Braden Yang John J Lee Tammie L S Benzinger Brian A Gordon Aristeidis Sotiras Alzheimer's Disease Neuroimaging Initiative Source Type: research

Lifestyle and incident dementia: A COSMIC individual participant data meta ‐analysis
DISCUSSION: Modifiable risk and protective factors appear relevant for dementia risk reduction across diverse geographical and sociodemographic groups.HIGHLIGHTS: A two-step individual participant data meta-analysis was conducted. This was done at a global scale using data from 21 ethno-regionally diverse cohorts. The association between a modifiable dementia risk score and dementia was examined. The association was modified by geographical region and age at baseline. Yet, modifiable dementia risk and protective factors appear relevant in all investigated groups and regions.PMID:38676366 | DOI:10.1002/alz.13846 (Source: Th...
Source: The Journal of Alzheimers Association - April 27, 2024 Category: Psychiatry Authors: Stephanie Van Asbroeck Sebastian K öhler Martin P J van Boxtel Darren M Lipnicki John D Crawford Erico Castro-Costa Maria Fernanda Lima-Costa Sergio Luis Blay Xiao Shifu Tao Wang Ling Yue Richard B Lipton Mindy J Katz Carol A Derby Ma ëlenn Guerchet Pie Source Type: research

Echocardiographic measures of the left heart and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact adults: The CABLE study
This study delineated the interrelationships between subclinical alterations in the left heart, cerebrospinal fluid (CSF), Alzheimer's disease (AD) biomarkers, and cognition.METHODS: Multiple linear regressions were conducted in 1244 cognitively normal participants (mean age = 65.5; 43% female) who underwent echocardiography (left atrial [LA] and left ventricular [LV] morphologic or functional parameters) and CSF AD biomarkers measurements. Mediating effects of AD pathologies were examined. Differences in cardiac parameters across ATN categories were tested using analysis of variance (ANOVA) and logistic regressions.RESULT...
Source: The Journal of Alzheimers Association - April 27, 2024 Category: Psychiatry Authors: He-Ying Hu Hao Hu Jing Jiang Yan-Lin Bi Yan Sun Ya-Nan Ou Lan Tan Jin-Tai Yu Source Type: research

Atrophy links lower novelty-related locus coeruleus connectivity to cognitive decline in preclinical AD
DISCUSSION: FCLC-MTL is implicated in Aβ-related cortical atrophy, suggesting that LC-MTL connectivity could confer neuroprotective effects in preclinical AD.HIGHLIGHTS: Novelty-related functional magnetic resonance imaging (fMRI) LC-medial temporal lobe (MTL) connectivity links to longitudinal Aβ-dependent atrophy. This relationship extended to higher Braak stage regions with increasing Aβ burden. Longitudinal MTL atrophy mediated the LC-MTL connectivity-cognition relationship. Our findings mirror the animal data on MTL atrophy following NE signal dysfunction.PMID:38676563 | DOI:10.1002/alz.13839 (Source: The Journal o...
Source: The Journal of Alzheimers Association - April 27, 2024 Category: Psychiatry Authors: Christoph Schneider Prokopis C Prokopiou Kathryn V Papp Nina Engels-Dom ínguez Stephanie Hsieh Truley A Juneau Aaron P Schultz Dorene M Rentz Reisa A Sperling Keith A Johnson Heidi I L Jacobs Source Type: research

Failure of the glymphatic system as possible link between lumbar spinal stenosis and dementia
Alzheimers Dement. 2024 Apr 27. doi: 10.1002/alz.13812. Online ahead of print.NO ABSTRACTPMID:38676574 | DOI:10.1002/alz.13812 (Source: The Journal of Alzheimers Association)
Source: The Journal of Alzheimers Association - April 27, 2024 Category: Psychiatry Authors: Pasquale Gallina Francesco Lolli Berardino Porfirio Source Type: research

Metabolomics profiling reveals distinct, sex-specific signatures in serum and brain metabolomes in mouse models of Alzheimer's disease
DISCUSSION: Several of our findings were consistent with results in humans, showing glycerophospholipids reduction in serum of apolipoprotein E (apoE) ε4 carriers and replicating the serum metabolic imprint of the APOE ε4 genotype. Our work thus represents a significant step toward translating metabolic dysregulation from model organisms to human AD.HIGHLIGHTS: This was a metabolomic assessment of two mouse models relevant to Alzheimer's disease. Mouse models exhibit broad sex-specific metabolic differences, similar to human study cohorts. The early-onset 5XFAD mouse model primarily alters brain metabolites while the lat...
Source: The Journal of Alzheimers Association - April 27, 2024 Category: Psychiatry Authors: Ravi S Pandey Mattias Arnold Richa Batra Jan Krumsiek Kevin P Kotredes Dylan Garceau Harriet Williams Michael Sasner Gareth R Howell Rima Kaddurah-Daouk Gregory W Carter Source Type: research