Influence of Thyroglobulin (Tg) Autoantibodies on Tg levels Measured by Different Methodologies: (IMA, LC-MS/MS and RIA)
CONCLUSIONS: 1) Between-method Tg variability necessitates method continuity when monitoring the Tg trends of TgAb- DTC patients. 2) The presence and concentration of TgAb appeared to have a lowering effect on serum Tg measured by all methodologies (IMA, MS and RIA). 3) Since the reliability of Tg measured in the presence of TgAb is often uncertain, the TgAb trend (measured by the same method) may be a useful surrogate DTC tumor marker.PMID:38686504 | DOI:10.1210/clinem/dgae286 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 30, 2024 Category: Endocrinology Authors: Ivana Petrovic Jonathan LoPresti Shireen Fatemi Andrew Gianoukakis Kenneth Burman Cristiane J Gomez-Lima Caroline T Nguyen Carole Ann Spencer Source Type: research

Basal Hyperglycemia Contributes More Than Fifty Percent to Time in Range in Pregnant Women with Type 1 Diabetes
CONCLUSIONS: Basal hyperglycemia was the major contributor to TIR during pregnancy. Along with controlling the postprandial hyperglycemia, pregnant women with T1DM who did not reach the target of TIR may benefit more from the optimization of insulin regimens focusing on reducing basal glucose.PMID:38686666 | DOI:10.1210/clinem/dgae291 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 30, 2024 Category: Endocrinology Authors: Ping Ling Daizhi Yang Chaofan Wang Xueying Zheng Sihui Luo Xubin Yang Hongrong Deng Wen Xu Jinhua Yan Jianping Weng Source Type: research

The association of cardiometabolic, diet and lifestyle parameters with plasma glucagon-like peptide-1: An IMI DIRECT study
CONCLUSION: These studies provide novel insights into the association between fasting and incremental GLP-1, metabolic traits of diabetes and obesity, and dietary intake and raise intriguing questions regarding the relevance of fasting GLP-1 in the pathophysiology T2D.PMID:38686701 | DOI:10.1210/clinem/dgae119 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 30, 2024 Category: Endocrinology Authors: Rebeca Eriksen Margaret C White Adem Y Dawed Isabel Garcia Perez Joram M Posma Mark Haid Sapna Sharma Cornelia Prehn Louise E Thomas Robert W Koivula Roberto Bizzotto Andrea Mari Giuseppe N Giordano Imre Pavo Jochen M Schwenk Federico De Masi Konstantinos Source Type: research

Associations Between Beverage Consumption and Risk of Microvascular Complications Among Individuals With Type 2 Diabetes
CONCLUSION: Higher consumption of ASBs and SSBs was linearly associated with an increased risk of microvascular complications in adults with T2D.PMID:38687598 | DOI:10.1210/clinem/dgae242 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 30, 2024 Category: Endocrinology Authors: Xiaoyu Lin Kai Zhu Zixin Qiu Rui Li Lin Li Qi Lu Ruyi Li Hancheng Yu Sen Liu Tianyu Guo Kun Yang Yunfei Liao An Pan Gang Liu Source Type: research

From Bench-to-Bedside: How Artificial Intelligence Is Changing Thyroid Nodule Diagnostics
CONCLUSIONS: Models predominantly used ultrasound images to predict malignancy. Of four FDA-approved products, only S-Detect was extensively validated. Implementing an AI model locally requires data sanitization and re-validation to ensure appropriate clinical performance.PMID:38679750 | DOI:10.1210/clinem/dgae277 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 28, 2024 Category: Endocrinology Authors: Vivek R Sant Ashwath Radhachandran Vedrana Ivezic Denise T Lee Masha J Livhits James X Wu Rinat Masamed Corey W Arnold Michael W Yeh William Speier Source Type: research

From Bench-to-Bedside: How Artificial Intelligence Is Changing Thyroid Nodule Diagnostics
CONCLUSIONS: Models predominantly used ultrasound images to predict malignancy. Of four FDA-approved products, only S-Detect was extensively validated. Implementing an AI model locally requires data sanitization and re-validation to ensure appropriate clinical performance.PMID:38679750 | DOI:10.1210/clinem/dgae277 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 28, 2024 Category: Endocrinology Authors: Vivek R Sant Ashwath Radhachandran Vedrana Ivezic Denise T Lee Masha J Livhits James X Wu Rinat Masamed Corey W Arnold Michael W Yeh William Speier Source Type: research

Colorectal Cancer and Subsequent Diabetes Risk: A Population-based Cohort Study in Taiwan
CONCLUSION: Patients with CRC are associated with an elevated risk of diabetes mellitus, and long-term chemotherapy, particularly involving capecitabine, increases diabetes mellitus risk. Thus, monitoring blood glucose levels is crucial for patients with CRC, especially during extended chemotherapy.PMID:38661006 | DOI:10.1210/clinem/dgae257 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 25, 2024 Category: Endocrinology Authors: Hsin-Yin Hsu Yih-Jong Chern Min-Shu Hsu Tzu-Lin Yeh Ming-Chieh Tsai Jing-Rong Jhuang Cheng-Tzu Hsieh Chun-Ju Chiang Wen-Chung Lee Lee-Ching Hwang Kuo-Liong Chien Source Type: research

A Body Shape Index as a Simple Anthropometric Marker of Abdominal Obesity and Risk of Cardiovascular Events
CONCLUSIONS: High ABSI is independently associated with incidence of cardiovascular events. ABSI calculation should be performed for evaluation of risk of cardiovascular events.PMID:38661044 | DOI:10.1210/clinem/dgae282 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 25, 2024 Category: Endocrinology Authors: Masato Kajikawa Tatsuya Maruhashi Shinji Kishimoto Takayuki Yamaji Takahiro Harada Yusuke Saito Aya Mizobuchi Shunsuke Tanigawa Yukiko Nakano Kazuaki Chayama Chikara Goto Farina Mohamad Yusoff Ayumu Nakashima Yukihito Higashi Source Type: research

Clinical Activity of Selpercatinib in RET-mutant Pheochromocytoma
CONCLUSION: These data support selpercatinib as an effective therapy against RET-mutant pheochromocytoma, adding to the diversity of RET-activated tumor types that may benefit from targeted RET inhibition.PMID:38661071 | DOI:10.1210/clinem/dgae283 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 25, 2024 Category: Endocrinology Authors: Barbara Deschler-Baier Bhavana Konda Erminia Massarelli Mimi I Hu Lori J Wirth Xiaojian Xu Jennifer Wright Roderick J Clifton-Bligh Source Type: research

Long-term cumulative incidence of clinically diagnosed retinopathy in the Finnish Diabetes Prevention Study
CONCLUSION: A higher cumulative HbA1c was significantly associated with a higher risk of retinopathy. No evidence was found for a beneficial effect of a 4-year lifestyle intervention on the long-term occurrence of clinically diagnosed retinopathy during a median of 22-year follow-up.PMID:38661084 | DOI:10.1210/clinem/dgae287 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 25, 2024 Category: Endocrinology Authors: Kai Kaarniranta Mikko Valtanen Sirkka Kein änen-Kiukaanniemi Jaakko Tuomilehto Jaana Lindstr öm Matti Uusitupa Source Type: research

Patient-Reported Outcomes in Autosomal Dominant Osteopetrosis: Findings from the Osteopetrosis Registry Study
CONCLUSIONS: Data from this registry demonstrate the broad spectrum of ADO disease severity and high impact on health-related quality of life in adults with ADO.PMID:38661205 | DOI:10.1210/clinem/dgae285 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 25, 2024 Category: Endocrinology Authors: Lynda E Polgreen Eva Villa-Lopez Liz Chen Ziyue Liu Amy Katz Corinne Parks-Schenck Marian Hart Erik A Imel Michael J Econs Source Type: research

Prepubertal children with obesity have high free IGF-1 levels and accelerated growth despite reduced pappalysin levels
CONCLUSION: Increased circulating total and free IGF-I, insulin and IGF-II may all contribute to the increased rate of prepubertal growth and bone maturation observed in children with obesity, with STC2 possibly being involved.PMID:38662803 | DOI:10.1210/clinem/dgae288 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 25, 2024 Category: Endocrinology Authors: Álvaro Martín-Rivada Gabriel Á Martos-Moreno Santiago Guerra-Cantera Ana Campillo-Calatayud Claus Oxvig Jan Frystyk Julie A Chowen Vicente Barrios Jes ús Argente Source Type: research

Colorectal Cancer and Subsequent Diabetes Risk: A Population-based Cohort Study in Taiwan
CONCLUSION: Patients with CRC are associated with an elevated risk of diabetes mellitus, and long-term chemotherapy, particularly involving capecitabine, increases diabetes mellitus risk. Thus, monitoring blood glucose levels is crucial for patients with CRC, especially during extended chemotherapy.PMID:38661006 | DOI:10.1210/clinem/dgae257 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 25, 2024 Category: Endocrinology Authors: Hsin-Yin Hsu Yih-Jong Chern Min-Shu Hsu Tzu-Lin Yeh Ming-Chieh Tsai Jing-Rong Jhuang Cheng-Tzu Hsieh Chun-Ju Chiang Wen-Chung Lee Lee-Ching Hwang Kuo-Liong Chien Source Type: research

A Body Shape Index as a Simple Anthropometric Marker of Abdominal Obesity and Risk of Cardiovascular Events
CONCLUSIONS: High ABSI is independently associated with incidence of cardiovascular events. ABSI calculation should be performed for evaluation of risk of cardiovascular events.PMID:38661044 | DOI:10.1210/clinem/dgae282 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 25, 2024 Category: Endocrinology Authors: Masato Kajikawa Tatsuya Maruhashi Shinji Kishimoto Takayuki Yamaji Takahiro Harada Yusuke Saito Aya Mizobuchi Shunsuke Tanigawa Yukiko Nakano Kazuaki Chayama Chikara Goto Farina Mohamad Yusoff Ayumu Nakashima Yukihito Higashi Source Type: research

Clinical Activity of Selpercatinib in RET-mutant Pheochromocytoma
CONCLUSION: These data support selpercatinib as an effective therapy against RET-mutant pheochromocytoma, adding to the diversity of RET-activated tumor types that may benefit from targeted RET inhibition.PMID:38661071 | DOI:10.1210/clinem/dgae283 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - April 25, 2024 Category: Endocrinology Authors: Barbara Deschler-Baier Bhavana Konda Erminia Massarelli Mimi I Hu Lori J Wirth Xiaojian Xu Jennifer Wright Roderick J Clifton-Bligh Source Type: research