Comparison of SP263 and 22C3 pharmDx assays to test programmed death ligand ‐1 (PD‐L1) expression in surgically resected non‐small cell lung cancer
ConclusionsThis study showed a high concordance of PD-L1 expression with the SP263 and 22C3 assays. Further studies examining the therapeutic effects of adjuvant atezolizumab are required. (Source: Thoracic Cancer)
Source: Thoracic Cancer - May 3, 2024 Category: Cancer & Oncology Authors: Naoko Shigeta,
Shuji Murakami,
Tomoyuki Yokose,
Tetsuya Isaka,
Kanako Shinada,
Takuya Nagashima,
Hiroyuki Adachi,
Shunsuke Shigefuku,
Kotaro Murakami,
Jun Miura,
Noritake Kikunishi,
Kozue Watabe,
Haruhiro Saito,
Hiroyuki Ito Tags: ORIGINAL ARTICLE Source Type: research
Concomitant osimertinib and antituberculosis therapy in an elderly patient with EGFR ‐mutated lung cancer and pulmonary tuberculosis: A case report
We report a case of successful treatment involving the concomitant administration of osimertinib and antituberculosis drugs in an older patient, an 89-year-old female, diagnosed with epidermal growth factor receptor (EGFR)-mutant lung cancer and pulmonary tuberculosis. Accumulating evidence is warranted to develop an optimal treatment strategy for patients with lung cancer and tuberculosis. (Source: Thoracic Cancer)
Source: Thoracic Cancer - May 3, 2024 Category: Cancer & Oncology Authors: Hiroaki Matsuura,
Hisao Higo,
Tadahiro Kuribayashi,
Akihiko Tamaoki,
Takamasa Nakasuka,
Mari Uno,
Go Makimoto,
Kiichiro Ninomiya,
Masanori Fujii,
Kammei Rai,
Eiki Ichihara,
Katsuyuki Hotta,
Nobuaki Miyahara,
Masahiro Tabata,
Yoshinobu Maeda, Tags: CASE REPORT Source Type: research
Issue Information
(Source: Thoracic Cancer)
Source: Thoracic Cancer - May 2, 2024 Category: Cancer & Oncology Tags: ISSUE INFORMATION Source Type: research
Pulmonary pleomorphic carcinoma arising in mixed squamous and glandular papilloma: A case report
The tumor was composed of fibrovascular cores and papillomatous fronds lined by pseudostratified glandular epithelium. A lesion covered with keratinizing squamous epithelium was also observed. In addition, the solid part beneath the mild atypical squamous epithelia was composed of malignant-appearing squamous cells and spindle-shaped atypical cells. Therefore, we interpreted that pleomorphic carcinoma (squamous cell carcinoma and spindle cell carcinoma) arose in mixed papilloma. AbstractSolitary pulmonary papillomas (SPPs) are rare lung neoplasms. Histologically, SPP is classified into three subtypes, and mixed squamous an...
Source: Thoracic Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Hiroyuki Nitanda,
Taku Homma,
Ryo Taguchi,
Tetsuya Umesaki,
Yoshinobu Ichiki,
Hirozo Sakaguchi,
Hironori Ishida Tags: CASE REPORT Source Type: research
A novel evaluation model of image registration for cone ‐beam computed tomography guided lung cancer radiotherapy
ConclusionsThis study successfully developed a clinically relevant weighted evaluation model for CBCT-guided lung cancer radiotherapy. Validation confirmed the grayscale method's optimal performance in ipsilateral structure registration. (Source: Thoracic Cancer)
Source: Thoracic Cancer - May 1, 2024 Category: Cancer & Oncology Authors: Yimei Liu,
Meining Chen,
Jianlan Fang,
Liangjie Xiao,
Songran Liu,
Qiwen Li,
Bo Qiu,
Runda Huang,
Jun Zhang,
Yinglin Peng Tags: ORIGINAL ARTICLE Source Type: research
Efficiency of endoscopic artificial intelligence in the diagnosis of early esophageal cancer
ConclusionAI-assistance can diagnose early EC and its infiltration depth more accurately, which can help in its early intervention and the customization of personalized treatment plans. Therefore, AI systems have great potential in the early diagnosis of EC. (Source: Thoracic Cancer)
Source: Thoracic Cancer - April 30, 2024 Category: Cancer & Oncology Authors: Yongkang Tao,
Long Fang,
Geng Qin,
Yingying Xu,
Shuang Zhang,
Xiangrong Zhang,
Shiyu Du Tags: ORIGINAL ARTICLE Source Type: research
A liquid biopsy assay for the noninvasive detection of lymph node metastases in T1 lung adenocarcinoma
ConclusionsWe have established a new risk prediction model using serum samples from T1 LUAD patients, enabling noninvasive identification of those with positive lymph node metastases. (Source: Thoracic Cancer)
Source: Thoracic Cancer - April 29, 2024 Category: Cancer & Oncology Authors: Xin Li,
Yang Gu,
Bin Hu,
Ming ‐Ming Shao,
Hui Li Tags: ORIGINAL ARTICLE Source Type: research
Automated CT quantification of interstitial lung abnormality in patients with resectable stage I non ‐small cell lung cancer: Prognostic significance
ConclusionsThe automated CT quantification of ILA, based on the Fleischner Society definition, was significantly linked to poorer survival and recurrence in patients with stage I NSCLC. (Source: Thoracic Cancer)
Source: Thoracic Cancer - April 29, 2024 Category: Cancer & Oncology Authors: Jae Ho Chung,
Jong Myung Park,
Do Hyung Kim Tags: ORIGINAL ARTICLE Source Type: research
Exploring previously used thresholds for computed tomography ‐defined low skeletal muscle mass in predicting functional limitations among lung cancer patients
ConclusionFixed cutoffs for CT-defined low skeletal muscle mass may inadequately predict PFLs, potentially overlooking declining physical functions in patients with lung cancer. (Source: Thoracic Cancer)
Source: Thoracic Cancer - April 27, 2024 Category: Cancer & Oncology Authors: Shiva Raj Timsina,
Wiwatana Tanomkiat,
Sarayut L. Geater,
Natee Ina Tags: ORIGINAL ARTICLE Source Type: research
Long ‐term survival of a patient with epidermal growth factor receptor (EGFR)‐mutant non‐small cell lung cancer (NSCLC) and untreated multiple brain metastases treated with zorifertinib: A case report
Long OS achieved in NSCLC patients with EGFR mutation and untreated multiple BM after zorifertinib treatment. AbstractBrain metastases (BM) are common in patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) and confer poor prognoses. Zorifertinib (AZD3759), an EGFR-tyrosine kinase inhibitor (TKI) with high blood-brain barrier penetration, has previously demonstrated promising systemic and intracranial antitumor activity in phase 1 –3 studies. This is the first report of a patient withEGFR-mutant (exon 21 L858R) NSCLC and symptomatic untreated multiple BM who achieved a long over...
Source: Thoracic Cancer - April 26, 2024 Category: Cancer & Oncology Authors: Kang Li,
Bolin Chen,
Jingyi Wang,
Lin Wu Tags: CASE REPORT Source Type: research
Historical trends of breast cancer burden attributable to metabolic factors among Chinese women, 1990 –2019: A population‐based epidemiological study
ConclusionsAge was the main reason for the increase of attributable burden, and postmenopausal women were the high-risk groups. Therefore, targeted prevention measures should be developed to improve postmenopausal women's awareness and effectively reduce the prevalence of obesity and diabetes, thereby reducing the breast cancer burden caused by metabolic factors in China. (Source: Thoracic Cancer)
Source: Thoracic Cancer - April 26, 2024 Category: Cancer & Oncology Authors: Liang ‐Zi Zhang,
Qi‐Cheng Sun,
Hang‐Hang Luan,
Qian‐Qian Yuan,
Tong Deng,
Li‐Sha Luo,
Xiao‐Lin Tan Tags: ORIGINAL ARTICLE Source Type: research
Issue Information
(Source: Thoracic Cancer)
Source: Thoracic Cancer - April 26, 2024 Category: Cancer & Oncology Tags: ISSUE INFORMATION Source Type: research
Endotracheal enucleation and para ‐toluenesulfonamide injection for adenoid cystic carcinoma in the upper trachea: A novel therapeutic approach
We present a case of tracheal adenoid cystic carcinoma (ACC) treated with endotracheal enucleation followed by three doses of para-toluenesulfonamide (PTS)-lipiodol mixture injection. The treatment resulted in tumor eradication, improved airway patency, and absence of recurrence in 1 year, suggesting PTS as a promising alternative for inoperable ACC. AbstractWe present a case of an adenoid cystic carcinoma (ACC) located in the upper trachea, which resulted in significant airway blockage, that was unsuitable for surgical removal due to concerns about functional impairment. Instead, endotracheal enucleation via rigid bron...
Source: Thoracic Cancer - April 19, 2024 Category: Cancer & Oncology Authors: Hsiao ‐Hung Lu,
Shuenn‐Wen Kuo Tags: CASE REPORT Source Type: research
Circulating SMRP and CA ‐125 before and after pleurectomy decortication for pleural mesothelioma
ConclusionsLongitudinal changes in SMRP levels corresponded with a radiographic presence of disease in a subset of patients. SMRP surveillance could aid in detection of local recurrences, whereas CA-125 could be helpful in recognizing abdominal recurrences. (Source: Thoracic Cancer)
Source: Thoracic Cancer - April 17, 2024 Category: Cancer & Oncology Authors: Juuso Paajanen,
Ahmed Sadek,
William G. Richards,
Yue Xie,
Emanuele Mazzola,
Kristina Sidopoulos,
John Kuckelman,
Ritu R. Gill,
Raphael Bueno Tags: ORIGINAL ARTICLE Source Type: research
Efficacy and safety of novel immune checkpoint inhibitor ‐based combinations versus chemotherapy as first‐line treatment for patients with extensive‐stage small cell lung cancer: A network meta‐analysis
ConclusionPD-1/PD-L1 inhibitors-based combinations are associated with significant improvement in both PFS and OS for treatment-na ïve ES-SCLC patients. Benmelstobart plus anlotinib with chemotherapy (CT) yielded better survival benefit versus CT alone or other ICIs + CT with caution for more adverse effects along with the addition of an antiangiogenic agent. (Source: Thoracic Cancer)
Source: Thoracic Cancer - April 16, 2024 Category: Cancer & Oncology Authors: Chuang Yang,
Tiantian Xuan,
Qing Gong,
Xin Dai,
Chengjun Wang,
Rongyu Zhang,
Wen Zhao,
Jian Wang,
Weiming Yue,
Jisheng Li Tags: ORIGINAL ARTICLE Source Type: research
