Toxicologic Pathology Forum Opinion: Apoptosis/Single Cell Necrosis as a Possible Procedural Effect in Primate Brain Following Ice-Cold Saline Perfusion
Toxicol Pathol. 2024 Apr 25:1926233241247044. doi: 10.1177/01926233241247044. Online ahead of print.ABSTRACTNonclinical studies of test articles (TAs) in nonhuman primates are often designed to assess both biodistribution and toxicity. For this purpose, studies commonly use intravenous perfusion of ice-cold (2°C-8°C) saline to facilitate measurements of TA-associated nucleic acids and proteins, after which tissues undergo later fixation by immersion for histological processing and microscopic evaluation. Intriguingly, minimal apoptosis/single cell necrosis (A/SCN) of randomly distributed neural cells is evident in the ce...
Source: Toxicologic Pathology - April 25, 2024 Category: Pathology Authors: Brad Bolon Joy M Gary Source Type: research
Considerations for the Identification and Conveyance of Clinical Pathology Findings in Preclinical Toxicity Studies: Results From the 9th ESTP International Expert Workshop
Toxicol Pathol. 2024 Apr 25:1926233241245108. doi: 10.1177/01926233241245108. Online ahead of print.ABSTRACTThe European Society of Toxicologic Pathology (ESTP) organized a panel of 24 international experts from many fields of toxicologic clinical pathology (e.g., industry, academia, and regulatory) that came together in 2021 to align the use of terminology to convey the importance of clinical pathology findings in preclinical toxicity studies. An additional goal consisted of how to identify important findings in standard and nonstandard clinical pathology associated endpoints. This manuscript summarizes the information an...
Source: Toxicologic Pathology - April 25, 2024 Category: Pathology Authors: Tara Arndt Monika Keresztes Blanck Olivier L Boone Franck Chanut D Ennulat Ellen Evans Alexius Freyberger S Johannes C Frieke Kuper Pierre Maliver Peter O'Brien Lila Ramaiah Ian Roman Volker Strauss Petra Vinken Dana Walker Michael Winter Gabriele Pohlmey Source Type: research
Toxicologic Pathology Forum Opinion: Apoptosis/Single Cell Necrosis as a Possible Procedural Effect in Primate Brain Following Ice-Cold Saline Perfusion
Toxicol Pathol. 2024 Apr 25:1926233241247044. doi: 10.1177/01926233241247044. Online ahead of print.ABSTRACTNonclinical studies of test articles (TAs) in nonhuman primates are often designed to assess both biodistribution and toxicity. For this purpose, studies commonly use intravenous perfusion of ice-cold (2°C-8°C) saline to facilitate measurements of TA-associated nucleic acids and proteins, after which tissues undergo later fixation by immersion for histological processing and microscopic evaluation. Intriguingly, minimal apoptosis/single cell necrosis (A/SCN) of randomly distributed neural cells is evident in the ce...
Source: Toxicologic Pathology - April 25, 2024 Category: Pathology Authors: Brad Bolon Joy M Gary Source Type: research
Considerations for the Identification and Conveyance of Clinical Pathology Findings in Preclinical Toxicity Studies: Results From the 9th ESTP International Expert Workshop
Toxicol Pathol. 2024 Apr 25:1926233241245108. doi: 10.1177/01926233241245108. Online ahead of print.ABSTRACTThe European Society of Toxicologic Pathology (ESTP) organized a panel of 24 international experts from many fields of toxicologic clinical pathology (e.g., industry, academia, and regulatory) that came together in 2021 to align the use of terminology to convey the importance of clinical pathology findings in preclinical toxicity studies. An additional goal consisted of how to identify important findings in standard and nonstandard clinical pathology associated endpoints. This manuscript summarizes the information an...
Source: Toxicologic Pathology - April 25, 2024 Category: Pathology Authors: Tara Arndt Monika Keresztes Blanck Olivier L Boone Franck Chanut D Ennulat Ellen Evans Alexius Freyberger S Johannes C Frieke Kuper Pierre Maliver Peter O'Brien Lila Ramaiah Ian Roman Volker Strauss Petra Vinken Dana Walker Michael Winter Gabriele Pohlmey Source Type: research
Toxicologic Pathology Forum Opinion: Apoptosis/Single Cell Necrosis as a Possible Procedural Effect in Primate Brain Following Ice-Cold Saline Perfusion
Toxicol Pathol. 2024 Apr 25:1926233241247044. doi: 10.1177/01926233241247044. Online ahead of print.ABSTRACTNonclinical studies of test articles (TAs) in nonhuman primates are often designed to assess both biodistribution and toxicity. For this purpose, studies commonly use intravenous perfusion of ice-cold (2°C-8°C) saline to facilitate measurements of TA-associated nucleic acids and proteins, after which tissues undergo later fixation by immersion for histological processing and microscopic evaluation. Intriguingly, minimal apoptosis/single cell necrosis (A/SCN) of randomly distributed neural cells is evident in the ce...
Source: Toxicologic Pathology - April 25, 2024 Category: Pathology Authors: Brad Bolon Joy M Gary Source Type: research
Considerations for the Identification and Conveyance of Clinical Pathology Findings in Preclinical Toxicity Studies: Results From the 9th ESTP International Expert Workshop
Toxicol Pathol. 2024 Apr 25:1926233241245108. doi: 10.1177/01926233241245108. Online ahead of print.ABSTRACTThe European Society of Toxicologic Pathology (ESTP) organized a panel of 24 international experts from many fields of toxicologic clinical pathology (e.g., industry, academia, and regulatory) that came together in 2021 to align the use of terminology to convey the importance of clinical pathology findings in preclinical toxicity studies. An additional goal consisted of how to identify important findings in standard and nonstandard clinical pathology associated endpoints. This manuscript summarizes the information an...
Source: Toxicologic Pathology - April 25, 2024 Category: Pathology Authors: Tara Arndt Monika Keresztes Blanck Olivier L Boone Franck Chanut D Ennulat Ellen Evans Alexius Freyberger S Johannes C Frieke Kuper Pierre Maliver Peter O'Brien Lila Ramaiah Ian Roman Volker Strauss Petra Vinken Dana Walker Michael Winter Gabriele Pohlmey Source Type: research
Toxicologic Pathology Forum Opinion: Apoptosis/Single Cell Necrosis as a Possible Procedural Effect in Primate Brain Following Ice-Cold Saline Perfusion
Toxicol Pathol. 2024 Apr 25:1926233241247044. doi: 10.1177/01926233241247044. Online ahead of print.ABSTRACTNonclinical studies of test articles (TAs) in nonhuman primates are often designed to assess both biodistribution and toxicity. For this purpose, studies commonly use intravenous perfusion of ice-cold (2°C-8°C) saline to facilitate measurements of TA-associated nucleic acids and proteins, after which tissues undergo later fixation by immersion for histological processing and microscopic evaluation. Intriguingly, minimal apoptosis/single cell necrosis (A/SCN) of randomly distributed neural cells is evident in the ce...
Source: Toxicologic Pathology - April 25, 2024 Category: Pathology Authors: Brad Bolon Joy M Gary Source Type: research
Considerations for the Identification and Conveyance of Clinical Pathology Findings in Preclinical Toxicity Studies: Results From the 9th ESTP International Expert Workshop
Toxicol Pathol. 2024 Apr 25:1926233241245108. doi: 10.1177/01926233241245108. Online ahead of print.ABSTRACTThe European Society of Toxicologic Pathology (ESTP) organized a panel of 24 international experts from many fields of toxicologic clinical pathology (e.g., industry, academia, and regulatory) that came together in 2021 to align the use of terminology to convey the importance of clinical pathology findings in preclinical toxicity studies. An additional goal consisted of how to identify important findings in standard and nonstandard clinical pathology associated endpoints. This manuscript summarizes the information an...
Source: Toxicologic Pathology - April 25, 2024 Category: Pathology Authors: Tara Arndt Monika Keresztes Blanck Olivier L Boone Franck Chanut D Ennulat Ellen Evans Alexius Freyberger S Johannes C Frieke Kuper Pierre Maliver Peter O'Brien Lila Ramaiah Ian Roman Volker Strauss Petra Vinken Dana Walker Michael Winter Gabriele Pohlmey Source Type: research
Toxicologic Pathology Forum Opinion: Apoptosis/Single Cell Necrosis as a Possible Procedural Effect in Primate Brain Following Ice-Cold Saline Perfusion
Toxicol Pathol. 2024 Apr 25:1926233241247044. doi: 10.1177/01926233241247044. Online ahead of print.ABSTRACTNonclinical studies of test articles (TAs) in nonhuman primates are often designed to assess both biodistribution and toxicity. For this purpose, studies commonly use intravenous perfusion of ice-cold (2°C-8°C) saline to facilitate measurements of TA-associated nucleic acids and proteins, after which tissues undergo later fixation by immersion for histological processing and microscopic evaluation. Intriguingly, minimal apoptosis/single cell necrosis (A/SCN) of randomly distributed neural cells is evident in the ce...
Source: Toxicologic Pathology - April 25, 2024 Category: Pathology Authors: Brad Bolon Joy M Gary Source Type: research
Considerations for the Identification and Conveyance of Clinical Pathology Findings in Preclinical Toxicity Studies: Results From the 9th ESTP International Expert Workshop
Toxicol Pathol. 2024 Apr 25:1926233241245108. doi: 10.1177/01926233241245108. Online ahead of print.ABSTRACTThe European Society of Toxicologic Pathology (ESTP) organized a panel of 24 international experts from many fields of toxicologic clinical pathology (e.g., industry, academia, and regulatory) that came together in 2021 to align the use of terminology to convey the importance of clinical pathology findings in preclinical toxicity studies. An additional goal consisted of how to identify important findings in standard and nonstandard clinical pathology associated endpoints. This manuscript summarizes the information an...
Source: Toxicologic Pathology - April 25, 2024 Category: Pathology Authors: Tara Arndt Monika Keresztes Blanck Olivier L Boone Franck Chanut D Ennulat Ellen Evans Alexius Freyberger S Johannes C Frieke Kuper Pierre Maliver Peter O'Brien Lila Ramaiah Ian Roman Volker Strauss Petra Vinken Dana Walker Michael Winter Gabriele Pohlmey Source Type: research
Toxicologic Pathology Forum Opinion: Apoptosis/Single Cell Necrosis as a Possible Procedural Effect in Primate Brain Following Ice-Cold Saline Perfusion
Toxicol Pathol. 2024 Apr 25:1926233241247044. doi: 10.1177/01926233241247044. Online ahead of print.ABSTRACTNonclinical studies of test articles (TAs) in nonhuman primates are often designed to assess both biodistribution and toxicity. For this purpose, studies commonly use intravenous perfusion of ice-cold (2°C-8°C) saline to facilitate measurements of TA-associated nucleic acids and proteins, after which tissues undergo later fixation by immersion for histological processing and microscopic evaluation. Intriguingly, minimal apoptosis/single cell necrosis (A/SCN) of randomly distributed neural cells is evident in the ce...
Source: Toxicologic Pathology - April 25, 2024 Category: Pathology Authors: Brad Bolon Joy M Gary Source Type: research
Considerations for the Identification and Conveyance of Clinical Pathology Findings in Preclinical Toxicity Studies: Results From the 9th ESTP International Expert Workshop
Toxicol Pathol. 2024 Apr 25:1926233241245108. doi: 10.1177/01926233241245108. Online ahead of print.ABSTRACTThe European Society of Toxicologic Pathology (ESTP) organized a panel of 24 international experts from many fields of toxicologic clinical pathology (e.g., industry, academia, and regulatory) that came together in 2021 to align the use of terminology to convey the importance of clinical pathology findings in preclinical toxicity studies. An additional goal consisted of how to identify important findings in standard and nonstandard clinical pathology associated endpoints. This manuscript summarizes the information an...
Source: Toxicologic Pathology - April 25, 2024 Category: Pathology Authors: Tara Arndt Monika Keresztes Blanck Olivier L Boone Franck Chanut D Ennulat Ellen Evans Alexius Freyberger S Johannes C Frieke Kuper Pierre Maliver Peter O'Brien Lila Ramaiah Ian Roman Volker Strauss Petra Vinken Dana Walker Michael Winter Gabriele Pohlmey Source Type: research
Toxicologic Pathology Forum Opinion: Apoptosis/Single Cell Necrosis as a Possible Procedural Effect in Primate Brain Following Ice-Cold Saline Perfusion
Toxicol Pathol. 2024 Apr 25:1926233241247044. doi: 10.1177/01926233241247044. Online ahead of print.ABSTRACTNonclinical studies of test articles (TAs) in nonhuman primates are often designed to assess both biodistribution and toxicity. For this purpose, studies commonly use intravenous perfusion of ice-cold (2°C-8°C) saline to facilitate measurements of TA-associated nucleic acids and proteins, after which tissues undergo later fixation by immersion for histological processing and microscopic evaluation. Intriguingly, minimal apoptosis/single cell necrosis (A/SCN) of randomly distributed neural cells is evident in the ce...
Source: Toxicologic Pathology - April 25, 2024 Category: Pathology Authors: Brad Bolon Joy M Gary Source Type: research
Considerations for the Identification and Conveyance of Clinical Pathology Findings in Preclinical Toxicity Studies: Results From the 9th ESTP International Expert Workshop
Toxicol Pathol. 2024 Apr 25:1926233241245108. doi: 10.1177/01926233241245108. Online ahead of print.ABSTRACTThe European Society of Toxicologic Pathology (ESTP) organized a panel of 24 international experts from many fields of toxicologic clinical pathology (e.g., industry, academia, and regulatory) that came together in 2021 to align the use of terminology to convey the importance of clinical pathology findings in preclinical toxicity studies. An additional goal consisted of how to identify important findings in standard and nonstandard clinical pathology associated endpoints. This manuscript summarizes the information an...
Source: Toxicologic Pathology - April 25, 2024 Category: Pathology Authors: Tara Arndt Monika Keresztes Blanck Olivier L Boone Franck Chanut D Ennulat Ellen Evans Alexius Freyberger S Johannes C Frieke Kuper Pierre Maliver Peter O'Brien Lila Ramaiah Ian Roman Volker Strauss Petra Vinken Dana Walker Michael Winter Gabriele Pohlmey Source Type: research
Difference in the Mechanism of Iron Overload-Enhanced Acute Hepatotoxicity Induced by Thioacetamide and Carbon Tetrachloride in Rats
Toxicol Pathol. 2024 Mar 25:1926233241235623. doi: 10.1177/01926233241235623. Online ahead of print.ABSTRACTIron overload has been recognized as a risk factor for liver disease; however, little is known about its pathological role in the modification of liver injury. The purpose of this study is to investigate the influence of iron overload on liver injury induced by two hepatotoxicants with different pathogenesis in rats. Rats were fed a control (Cont), 0.8% high-iron (0.8% Fe), or 1% high-iron diet (1% Fe) for 4 weeks and were then administered with saline, thioacetamide (TAA), or carbon tetrachloride (CCl4). Hepatic and...
Source: Toxicologic Pathology - March 26, 2024 Category: Pathology Authors: Yohei Inai Takeshi Izawa Tomomi Kamei Sho Fujiwara Miyuu Tanaka Jyoji Yamate Mitsuru Kuwamura Source Type: research
