Toxicology and Applied Pharmacology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Tracking the therapeutic efficacy of a ketone mono ester and β-hydroxybutyrate for ulcerative colitis in rats: New perspectives
This study found that while both exogenous β-hydroxybutyrate and BD-AcAc 2 produced the same levels of plasma β-hydroxybutyrate, BD-AcAc 2 demonstrated superior effectiveness in mitigating dextran sodium sulfate-induced UC in rats. The mechanism of action involves modulating the NF-κB signaling, inhibiting the NLRP3 inflammasome, regulating antioxidant capacity, controlling tight junction protein expression and a potential to inhibit apoptosis and pyroptosis. Certainly, BD-AcAc 2's anti-inflammatory effects require more than just increasing plasma β-hydroxybutyrate levels and other factors contribute to its efficacy. L...
Source: Toxicology and Applied Pharmacology - April 27, 2024 Category: Toxicology Authors: Osama A Mohammed Sameh Saber Mustafa Ahmed Abdel-Reheim Mohannad Mohammad S Alamri Jaber Alfaifi Masoud I E Adam Muffarah Hamid Alharthi Ali M S Eleragi Hanan B Eltahir Mohamed Osama Abdalla Emad Bahashwan Elwathiq Khalid Ibrahim Assad Ali Rezigalla Sameh Source Type: research

Identification of early events in nitrogen mustard pulmonary toxicity that are independent of infiltrating inflammatory cells using precision cut lung slices
Toxicol Appl Pharmacol. 2024 Apr 25:116941. doi: 10.1016/j.taap.2024.116941. Online ahead of print.ABSTRACTNitrogen mustard (NM; mechlorethamine) is a cytotoxic vesicant known to cause acute lung injury which can progress to chronic disease. Due to the complex nature of NM injury, it has been difficult to analyze early responses of resident lung cells that initiate inflammation and disease progression. To investigate this, we developed a model of acute NM toxicity using murine precision cut lung slices (PCLS), which contain all resident lung cell populations. PCLS were exposed to NM (1-100 μM) for 0.5-3 h and analyzed 1 a...
Source: Toxicology and Applied Pharmacology - April 27, 2024 Category: Toxicology Authors: Alyssa Bellomo Julia Herbert Melissa J Kudlak Jeffrey D Laskin Andrew J Gow Debra L Laskin Source Type: research

L-theanine abates oxidative stress and mitochondrial dysfunction in myocardial ischemia-reperfusion injury by positively regulating the antioxidant response
In conclusion, L-THE confers cardioprotection against I/R injury by preventing oxidative stress, protecting mitochondrial function, and promoting overexpression of antioxidant genes. More studies are needed to place L-THE at the forefront of cardiovascular research and recommend its therapeutic use.PMID:38677602 | DOI:10.1016/j.taap.2024.116940 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - April 27, 2024 Category: Toxicology Authors: Wylly Rams és García-Niño Francisco Correa Alejandra Mar ía Zúñiga-Muñoz Aldo Jos é-Rodríguez Patricio Casta ñeda-Gómez Edson Mej ía-Díaz Source Type: research

A simple and rapid pre-clinical in vivo model reveals comparative cardiotoxicity profiles of kinase inhibitors
Toxicol Appl Pharmacol. 2024 Apr 25:116944. doi: 10.1016/j.taap.2024.116944. Online ahead of print.ABSTRACTDespite significant success, targeted therapeutics such as kinase inhibitors (KIs) still pose adverse events such as the cardiotoxicity. There is a lot of variation in the type and intensity of cardiotoxicity caused by different KIs and current pre-clinical models are inadequate to predict it. Thus, there is a need to develop more simple and rapid models for screening of novel KIs at the pre-clinical step itself. We thus aimed to establish a rapid and robust pre-clinical animal model for predicting cardiotoxicity of K...
Source: Toxicology and Applied Pharmacology - April 27, 2024 Category: Toxicology Authors: Qudrathulla Khan Quadri Mohammed Nusrath Banu Shilpa Reddy Police Sharvani Palakurthy Sangeetha Thota Sri Poornima Padamati Krishna Chaitanya Puligundla Nageswara Rao Amanchi Rama Krishna Kancha Source Type: research

Differential inhibition of sildenafil and macitentan on saxagliptin metabolism
Toxicol Appl Pharmacol. 2024 Apr 24;486:116934. doi: 10.1016/j.taap.2024.116934. Online ahead of print.ABSTRACTThe development of diabetes mellitus (DM) is generally accompanied by erectile dysfunction (ED) and pulmonary arterial hypertension (PAH), which increases the use of combination drug therapy and the risk of drug-drug interactions. Saxagliptin for the treatment of DM, sildenafil for the treatment of ED and PAH, and macitentan for the treatment of PAH are all substrates of CYP3A4, which indicates their potential involvement in drug-drug interactions. Therefore, we investigated potential pharmacokinetic interactions ...
Source: Toxicology and Applied Pharmacology - April 25, 2024 Category: Toxicology Authors: Ge-Xin Dai Wei Tan Yuxin Shen Dongdong Lin Ren-Ai Xu Qianmeng Lin Zhen Wei Source Type: research

Differential inhibition of sildenafil and macitentan on saxagliptin metabolism
Toxicol Appl Pharmacol. 2024 Apr 23:116934. doi: 10.1016/j.taap.2024.116934. Online ahead of print.ABSTRACTThe development of diabetes mellitus (DM) is generally accompanied by erectile dysfunction (ED) and pulmonary arterial hypertension (PAH), which increase the use of combination drug therapy and the risk of drug-drug interactions. Saxagliptin for the treatment of DM, sildenafil for the treatment of ED and PAH, and macitentan for the treatment of PAH are all substrates of CYP3A4, which indicates their potential involvement in drug-drug interactions. Therefore, we investigated potential pharmacokinetic interactions betwe...
Source: Toxicology and Applied Pharmacology - April 25, 2024 Category: Toxicology Authors: Ge-Xin Dai Wei Tan Yuxin Shen Dongdong Lin Ren-Ai Xu Qianmeng Lin Zhen Wei Source Type: research

The 11 < sup > th < /sup > Conference on metal toxicity and carcinogenesis
Toxicol Appl Pharmacol. 2024 Apr 20:116935. doi: 10.1016/j.taap.2024.116935. Online ahead of print.ABSTRACTMetal exposure is linked to numerous pathological outcomes including cancer, cardiovascular disease, and diabetes. Over the past decades, we have made significant progress in our understanding of how metals are linked to disease, but there is still much to learn. In October 2022, experts studying the consequences of metal exposures met in Montréal, Québec, to discuss recent advances and knowledge gaps for future research. Here, we present a summary of presentations and discussions had at the meeting.PMID:38648938 | ...
Source: Toxicology and Applied Pharmacology - April 22, 2024 Category: Toxicology Authors: Koren K Mann Ke Jian Lu Source Type: research

Dysregulation of adipogenesis and disrupted lipid metabolism by the antidepressants citalopram and sertraline
Toxicol Appl Pharmacol. 2024 Apr 19:116937. doi: 10.1016/j.taap.2024.116937. Online ahead of print.ABSTRACTSelective Serotonin Reuptake Inhibitors (SSRIs) are widely used medications for the treatment of major depressive disorder. However, long-term SSRI use has been associated with weight gain and altered lipid profiles. These findings suggest that SSRIs may have negative effects on metabolism. Exposure to certain chemicals called 'obesogens' are known to promote lipid accumulation and obesity by modulating adipogenesis. Here, we investigated whether citalopram (CIT) and sertraline (SER) interfere with the process of adip...
Source: Toxicology and Applied Pharmacology - April 21, 2024 Category: Toxicology Authors: Deniz Bozdag Jeroen van Voorthuizen Nikita Korpel Sander Lentz Hande Gurer-Orhan Jorke H Kamstra Source Type: research

Protective effects of microbial biosurfactants produced by Bacillus halotolerans and Candida parapsilosis on bleomycin-induced pulmonary fibrosis in mice: Impact of antioxidant, anti-inflammatory and anti-fibrotic properties via TGF- β1/Smad-3 pathway and miRNA-326
Toxicol Appl Pharmacol. 2024 Apr 19:116939. doi: 10.1016/j.taap.2024.116939. Online ahead of print.ABSTRACTIdiopathic pulmonary fibrosis (IPF) is an irreversible disease which considered the most fatal pulmonary fibrosis. Pulmonary toxicity including IPF is the most severe adverse effect of bleomycin, the chemotherapeutic agent. Based on the fact that, exogenous surfactants could induce alveolar stabilization in many lung diseases, the aim of this study was to explore the effects of low cost biosurfactants, surfactin (SUR) and sophorolipids (SLs), against bleomycin-induced pulmonary fibrosis in mice due to their antioxidan...
Source: Toxicology and Applied Pharmacology - April 21, 2024 Category: Toxicology Authors: Amria M Mousa Mohamed U Nooman Samah S Abbas Sahar M Gebril Mohamed Abdelraof Amr S Al-Kashef Source Type: research

Synergistic anticancer effects of ginsenoside CK and gefitinib against gefitinib-resistant NSCLC by regulating the balance of angiogenic factors through HIF-1 α/VEGF
In conclusion, ginsenoside CK improved the resistance of gefitinib by regulating the balance of angiogenic factors through down-regulating the HIF-1α/VEGF signaling pathway, providing a theoretical basis for improving the clinical efficacy of gefitinib and applying combined strategies to overcome drug resistance.PMID:38642809 | DOI:10.1016/j.taap.2024.116938 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - April 20, 2024 Category: Toxicology Authors: Xiaoping Song Lina Wang Panpan Cai Ying Xu Qingchao Liu Daidi Fan Source Type: research

AhR signaling modulates Ferroptosis by regulating SLC7A11 expression
Toxicol Appl Pharmacol. 2024 Apr 17:116936. doi: 10.1016/j.taap.2024.116936. Online ahead of print.ABSTRACTThe aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is pivotal in development, metabolic homeostasis, and immune responses. While recent research has highlighted AhR's significant role in modulating oxidative stress responses, its mechanistic relationship with ferroptosis-an iron-dependent, non-apoptotic cell death-remains to be fully elucidated. In our study, we discovered that AhR plays a crucial role in ferroptosis, in part by transcriptionally regulating the expression of the solute...
Source: Toxicology and Applied Pharmacology - April 19, 2024 Category: Toxicology Authors: Ziyue Kou Franklin Tram Tania Colon Yvette Shteynfeld Suwon Noh Fei Chen Byeong Hyeok Choi Wei Dai Source Type: research

Di-n-butyl phthalate induces toxicity in male fetal mouse testicular development by regulating the MAPK signaling pathway
In conclusion, our study provides the first evidence that the MAPK signaling pathway is involved in DBP-induced reproductive toxicity and highlights the importance of JNK1 as a potential target of DBP in inducing reproductive toxicity.PMID:38631520 | DOI:10.1016/j.taap.2024.116933 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - April 17, 2024 Category: Toxicology Authors: Xinwei Wan Xudong Cui Xiang Wang Mingyang Feng Shinan Wei Jia Yu Sha Cheng Heng Luo Jianxin Hu Source Type: research