Exposure to the phthalate metabolite MEHP impacts survival and growth of human ovarian follicles in vitro
Toxicology. 2024 Apr 27:153815. doi: 10.1016/j.tox.2024.153815. Online ahead of print.ABSTRACTPhthalates are found in everyday items like plastics and personal care products. There is an increasing concern that continuous exposure can adversely affect female fertility. However, experimental data are lacking to establish causal links between exposure and disease in humans. To address this gap, we tested the effects of a common phthalate metabolite, mono-(2-ethylhexyl) phthalate (MEHP), on adult human ovaries in vitro using an epidemiologically determined human-relevant concentration range (2.05nM - 20.51mM). Histomorphologi...
Source: Toxicology - April 30, 2024 Category: Toxicology Authors: Eleftheria Maria Panagiotou Anastasios Damdimopoulos Tianyi Li Elisabeth Moussaud-Lamodi ère Mikael Pedersen Filipa Lebre Karin Pettersson Catarina Arnelo Kiriaki Papaikonomou Ernesto Alfaro-Moreno Cecilia Lindskog Terje Svingen Pauliina Damdimopoulou Source Type: research
Two thyroperoxidase-inhibiting chemicals induce shared transcriptional changes in hippocampus of developing rats
Toxicology. 2024 Apr 27:153822. doi: 10.1016/j.tox.2024.153822. Online ahead of print.ABSTRACTThyroid hormone (TH) system disrupting compounds can impair brain development by perturbing TH action during critical life stages. Human exposure to TH system disrupting chemicals is therefore of great concern. To better protect humans against such chemicals, sensitive test methods that can detect effects on the developing brain are critical. Worryingly, however, current test methods are not sensitive and specific towards TH-mediated effects. To address this shortcoming, we performed RNA-sequencing of rat brains developmentally ex...
Source: Toxicology - April 30, 2024 Category: Toxicology Authors: Louise Ramh øj Terje Svingen Bertrand Evrard Fr édéric Chalmel Marta Axelstad Source Type: research
A quantitative weight-of-evidence method for confidence assessment of adverse outcome pathway networks: a case study on chemical-induced liver steatosis
In conclusion, our study delivers a generic methodology for developing and assessing AOP networks. The quantitative WoE scoring method facilitates in determining the level of support for KERs within the optimized AOP network, offering valuable insights into its utility in both scientific research and regulatory contexts. KERs supported by robust evidence represent promising candidates for inclusion in an in vitro test battery for reliably predicting chemical-induced liver steatosis within regulatory frameworks.PMID:38677583 | DOI:10.1016/j.tox.2024.153814 (Source: Toxicology)
Source: Toxicology - April 27, 2024 Category: Toxicology Authors: Anouk Verhoeven Jonas van Ertvelde Joost Boeckmans Alexandra Gatzios Ramiro Jover Birgitte Lindeman Graciela Lopez-Soop Robim M Rodrigues Anna Rapisarda Julen Sanz-Serrano Marth Stinckens Sara Sepehri Marc Teunis Mathieu Vinken Jian Jiang Tamara Vanhaecke Source Type: research
A quantitative weight-of-evidence method for confidence assessment of adverse outcome pathway networks: a case study on chemical-induced liver steatosis
In conclusion, our study delivers a generic methodology for developing and assessing AOP networks. The quantitative WoE scoring method facilitates in determining the level of support for KERs within the optimized AOP network, offering valuable insights into its utility in both scientific research and regulatory contexts. KERs supported by robust evidence represent promising candidates for inclusion in an in vitro test battery for reliably predicting chemical-induced liver steatosis within regulatory frameworks.PMID:38677583 | DOI:10.1016/j.tox.2024.153814 (Source: Toxicology)
Source: Toxicology - April 27, 2024 Category: Toxicology Authors: Anouk Verhoeven Jonas van Ertvelde Joost Boeckmans Alexandra Gatzios Ramiro Jover Birgitte Lindeman Graciela Lopez-Soop Robim M Rodrigues Anna Rapisarda Julen Sanz-Serrano Marth Stinckens Sara Sepehri Marc Teunis Mathieu Vinken Jian Jiang Tamara Vanhaecke Source Type: research
A quantitative weight-of-evidence method for confidence assessment of adverse outcome pathway networks: a case study on chemical-induced liver steatosis
In conclusion, our study delivers a generic methodology for developing and assessing AOP networks. The quantitative WoE scoring method facilitates in determining the level of support for KERs within the optimized AOP network, offering valuable insights into its utility in both scientific research and regulatory contexts. KERs supported by robust evidence represent promising candidates for inclusion in an in vitro test battery for reliably predicting chemical-induced liver steatosis within regulatory frameworks.PMID:38677583 | DOI:10.1016/j.tox.2024.153814 (Source: Toxicology)
Source: Toxicology - April 27, 2024 Category: Toxicology Authors: Anouk Verhoeven Jonas van Ertvelde Joost Boeckmans Alexandra Gatzios Ramiro Jover Birgitte Lindeman Graciela Lopez-Soop Robim M Rodrigues Anna Rapisarda Julen Sanz-Serrano Marth Stinckens Sara Sepehri Marc Teunis Mathieu Vinken Jian Jiang Tamara Vanhaecke Source Type: research
Cannabidiol disrupts tryptophan metabolism in the human term placenta
Toxicology. 2024 Apr 23:153813. doi: 10.1016/j.tox.2024.153813. Online ahead of print.ABSTRACTThe increasing use of cannabis during pregnancy raises concerns about its impact on fetal development. While cannabidiol (CBD) shows therapeutic promise, its effects during pregnancy remain uncertain. We investigated CBD's influence on tryptophan (TRP) metabolism in the human placenta. TRP is an essential amino acid that is metabolized via the serotonin and kynurenine (KYN) pathways, which are critical for fetal neurodevelopment. We used human term villous placental explants, an advanced ex vivo model, to study CBD's impact on key...
Source: Toxicology - April 25, 2024 Category: Toxicology Authors: Ramon Portillo Cilia Abad Tetiana Synova Petr Kastner Heblik Daniel Radim Kucera Rona Karahoda Frantisek Staud Source Type: research
Cannabidiol disrupts tryptophan metabolism in the human term placenta
Toxicology. 2024 Apr 23:153813. doi: 10.1016/j.tox.2024.153813. Online ahead of print.ABSTRACTThe increasing use of cannabis during pregnancy raises concerns about its impact on fetal development. While cannabidiol (CBD) shows therapeutic promise, its effects during pregnancy remain uncertain. We investigated CBD's influence on tryptophan (TRP) metabolism in the human placenta. TRP is an essential amino acid that is metabolized via the serotonin and kynurenine (KYN) pathways, which are critical for fetal neurodevelopment. We used human term villous placental explants, an advanced ex vivo model, to study CBD's impact on key...
Source: Toxicology - April 25, 2024 Category: Toxicology Authors: Ramon Portillo Cilia Abad Tetiana Synova Petr Kastner Heblik Daniel Radim Kucera Rona Karahoda Frantisek Staud Source Type: research
Systematic literature review of heavy metal contamination of the Nigerian environment from E-waste management: associated health and carcinogenic risk assessment
This study harmonizes primary data on HMs from e-waste in different Nigerian environmental media including the air, soil, surface dust, water and plant. We estimated the possible health implications, single and aggregative soil and water pollution indices in adult and children, carcinogenic and non-carcinogenic risks secondary to HM exposure and mapped out the possible mechanism of carcinogenesis. Analysis showed that soil, water, surface dust and plant matrices in Nigerian environment are variedly but considerably contaminated with combination of HMs. The significantly high values of the hazard quotient and hazard index o...
Source: Toxicology - April 23, 2024 Category: Toxicology Authors: W M Owonikoko C G Alimba Source Type: research
Elevated intracellular Ca < sup > 2+ < /sup > functions downstream of mitodysfunction to induce Wallerian-like degeneration and necroptosis in organophosphorus-induced delayed neuropathy
This study was designed to investigate that deregulated cytosolic Ca2+ may function downstream of mitodysfunction in activating Wallerian-like degeneration and necroptosis in OPIDN. Adult hens were administrated a single dosage of 750 mg/kg tri-ortho-cresyl phosphate (TOCP), and then sacrificed at 1 day, 5 day, 10 day and 21 day post-exposure, respectively. Sciatic nerves and spinal cords were examined for pathological changes and proteins expression related to Wallerian-like degeneration and necroptosis. In vitro experiments using differentiated neuro-2a (N2a) cells were conducted to investigate the relationship among mit...
Source: Toxicology - April 23, 2024 Category: Toxicology Authors: Mingxue Song Kang Kang Shuai Wang Cuiqin Zhang Xiulan Zhao Fuyong Song Source Type: research
Ferroptosis is involved in trophoblast cells cytotoxicity induced by black phosphorus nanoparticles
Toxicology. 2024 Apr 21;505:153810. doi: 10.1016/j.tox.2024.153810. Online ahead of print.ABSTRACTBlack phosphorus (BP) is a new type of nanomaterial, which has been widely used in many biomedical fields due to its superior properties, but there are few studies on the toxicity of BP, especially in the reproductive system. To explore the effects of BP exposure on reproduction and reveal its molecular mechanism, we firstly investigated the potential toxicity of black phosphorus nanoparticles (BPNPs) in vivo. The results showed that BP exposure in pregnant mice can reduce the weight of fetal mice and placenta. H&E stainin...
Source: Toxicology - April 23, 2024 Category: Toxicology Authors: Ruolan You Yaming Mu Jiaqi Zhou Chunying Wang Zhenya Fang Yu Liu Shiyu Liu Qingfeng Zhai Changqing Zhang Source Type: research
Systematic literature review of heavy metal contamination of the Nigerian environment from E-waste management: associated health and carcinogenic risk assessment
This study harmonizes primary data on HMs from e-waste in different Nigerian environmental media including the air, soil, surface dust, water and plant. We estimated the possible health implications, single and aggregative soil and water pollution indices in adult and children, carcinogenic and non-carcinogenic risks secondary to HM exposure and mapped out the possible mechanism of carcinogenesis. Analysis showed that soil, water, surface dust and plant matrices in Nigerian environment are variedly but considerably contaminated with combination of HMs. The significantly high values of the hazard quotient and hazard index o...
Source: Toxicology - April 23, 2024 Category: Toxicology Authors: W M Owonikoko C G Alimba Source Type: research
Elevated intracellular Ca < sup > 2+ < /sup > functions downstream of mitodysfunction to induce Wallerian-like degeneration and necroptosis in organophosphorus-induced delayed neuropathy
This study was designed to investigate that deregulated cytosolic Ca2+ may function downstream of mitodysfunction in activating Wallerian-like degeneration and necroptosis in OPIDN. Adult hens were administrated a single dosage of 750 mg/kg tri-ortho-cresyl phosphate (TOCP), and then sacrificed at 1 day, 5 day, 10 day and 21 day post-exposure, respectively. Sciatic nerves and spinal cords were examined for pathological changes and proteins expression related to Wallerian-like degeneration and necroptosis. In vitro experiments using differentiated neuro-2a (N2a) cells were conducted to investigate the relationship among mit...
Source: Toxicology - April 23, 2024 Category: Toxicology Authors: Mingxue Song Kang Kang Shuai Wang Cuiqin Zhang Xiulan Zhao Fuyong Song Source Type: research
Ferroptosis is involved in human chorionic trophoblast cells cytotoxicity induced by black phosphorus nanoparticles
Toxicology. 2024 Apr 21:153810. doi: 10.1016/j.tox.2024.153810. Online ahead of print.ABSTRACTBlack phosphorus (BP) is a new type of nanomaterial, which has been widely used in many biomedical fields due to its superior properties, but there are few studies on the toxicity of BP, especially in the reproductive system. To explore the effects of BP exposure on reproduction and reveal its molecular mechanism, we firstly investigated the potential toxicity of black phosphorus nanoparticles (BPNPs) in vivo. The results showed that BP exposure in pregnant mice can reduce the weight of fetal mice and placenta. H&E staining fu...
Source: Toxicology - April 23, 2024 Category: Toxicology Authors: Ruolan You Yaming Mu Jiaqi Zhou Chunying Wang Zhenya Fang Yu Liu Shiyu Liu Qingfeng Zhai Changqing Zhang Source Type: research
Ferroptosis is involved in human chorionic trophoblast cells cytotoxicity induced by black phosphorus nanoparticles
Toxicology. 2024 Apr 21:153810. doi: 10.1016/j.tox.2024.153810. Online ahead of print.ABSTRACTBlack phosphorus (BP) is a new type of nanomaterial, which has been widely used in many biomedical fields due to its superior properties, but there are few studies on the toxicity of BP, especially in the reproductive system. To explore the effects of BP exposure on reproduction and reveal its molecular mechanism, we firstly investigated the potential toxicity of black phosphorus nanoparticles (BPNPs) in vivo. The results showed that BP exposure in pregnant mice can reduce the weight of fetal mice and placenta. H&E staining fu...
Source: Toxicology - April 23, 2024 Category: Toxicology Authors: Ruolan You Yaming Mu Jiaqi Zhou Chunying Wang Zhenya Fang Yu Liu Shiyu Liu Qingfeng Zhai Changqing Zhang Source Type: research
Systematic literature review of heavy metal contamination of the Nigerian environment from E-waste management: associated health and carcinogenic risk assessment
This study harmonizes primary data on HMs from e-waste in different Nigerian environmental media including the air, soil, surface dust, water and plant. We estimated the possible health implications, single and aggregative soil and water pollution indices in adult and children, carcinogenic and non-carcinogenic risks secondary to HM exposure and mapped out the possible mechanism of carcinogenesis. Analysis showed that soil, water, surface dust and plant matrices in Nigerian environment are variedly but considerably contaminated with combination of HMs. The significantly high values of the hazard quotient and hazard index o...
Source: Toxicology - April 23, 2024 Category: Toxicology Authors: W M Owonikoko C G Alimba Source Type: research
