A case of paralytic shellfish poisoning caused by consumption of visceral balls from geoduck Panopea japonica in Japan
Toxicon. 2024 Apr 27:107738. doi: 10.1016/j.toxicon.2024.107738. Online ahead of print.ABSTRACTIn the end of March 2018, an unprecedented food poisoning incident due to ingestion of the visceral balls of geoduck Panopea japonica occurred in Japan. The patient, presented with symptoms of numbness on the lips and general weakness, was diagnosed as paralytic shellfish poisoning (PSP). The patient immediately treated with the mechanical ventilation recovered and left the hospital after 3 days treatment. Saxitoxins (STXs) in the plasma and urinary samples collected from the patient on the first and second day after hospitalizat...
Source: Toxicon - April 30, 2024 Category: Toxicology Authors: Ryuichi Watanabe Hiroshi Oikawa Takefumi Tsunemitsu Kazutaka Miyahara Mayu Ozawa Satoshi Numano Hajime Uchida Ryoji Matsushima Toshiyuki Suzuki Source Type: research
A case of paralytic shellfish poisoning caused by consumption of visceral balls from geoduck Panopea japonica in Japan
Toxicon. 2024 Apr 27:107738. doi: 10.1016/j.toxicon.2024.107738. Online ahead of print.ABSTRACTIn the end of March 2018, an unprecedented food poisoning incident due to ingestion of the visceral balls of geoduck Panopea japonica occurred in Japan. The patient, presented with symptoms of numbness on the lips and general weakness, was diagnosed as paralytic shellfish poisoning (PSP). The patient immediately treated with the mechanical ventilation recovered and left the hospital after 3 days treatment. Saxitoxins (STXs) in the plasma and urinary samples collected from the patient on the first and second day after hospitalizat...
Source: Toxicon - April 30, 2024 Category: Toxicology Authors: Ryuichi Watanabe Hiroshi Oikawa Takefumi Tsunemitsu Kazutaka Miyahara Mayu Ozawa Satoshi Numano Hajime Uchida Ryoji Matsushima Toshiyuki Suzuki Source Type: research
Toxicity, biochemical and molecular docking studies of Acacia nilotica L., essential oils against insect pests
In this study, the essential oils were extracted from Acacia nilotica seed cotyledons, and their toxicity was tested against insect pests. Furthermore, the chemical components of the essential oils were identified through gas chromatography-mass spectrometry (GC-MS) analysis. The essential oil extracted from A. nilotica seeds exhibited the highest mortality rates of 60% and 98% in Culex quinquefasciatus, and 60% and 96.66% mortality in Plutella xylostella at 24 and 48 hours after treatment, respectively. The essential oils resulted in a lower LC50 of 159.263 ppm/mL, and LC90 of 320.930 ppm/mL within 24 hours. In 48 hours, ...
Source: Toxicon - April 27, 2024 Category: Toxicology Authors: Perumal Vivekanandhan Sulaiman Ali Alharbi Mohammad Javed Ansari Source Type: research
Toxicity, biochemical and molecular docking studies of Acacia nilotica L., essential oils against insect pests
In this study, the essential oils were extracted from Acacia nilotica seed cotyledons, and their toxicity was tested against insect pests. Furthermore, the chemical components of the essential oils were identified through gas chromatography-mass spectrometry (GC-MS) analysis. The essential oil extracted from A. nilotica seeds exhibited the highest mortality rates of 60% and 98% in Culex quinquefasciatus, and 60% and 96.66% mortality in Plutella xylostella at 24 and 48 hours after treatment, respectively. The essential oils resulted in a lower LC50 of 159.263 ppm/mL, and LC90 of 320.930 ppm/mL within 24 hours. In 48 hours, ...
Source: Toxicon - April 27, 2024 Category: Toxicology Authors: Perumal Vivekanandhan Sulaiman Ali Alharbi Mohammad Javed Ansari Source Type: research
Toxicity, biochemical and molecular docking studies of Acacia nilotica L., essential oils against insect pests
In this study, the essential oils were extracted from Acacia nilotica seed cotyledons, and their toxicity was tested against insect pests. Furthermore, the chemical components of the essential oils were identified through gas chromatography-mass spectrometry (GC-MS) analysis. The essential oil extracted from A. nilotica seeds exhibited the highest mortality rates of 60% and 98% in Culex quinquefasciatus, and 60% and 96.66% mortality in Plutella xylostella at 24 and 48 hours after treatment, respectively. The essential oils resulted in a lower LC50 of 159.263 ppm/mL, and LC90 of 320.930 ppm/mL within 24 hours. In 48 hours, ...
Source: Toxicon - April 27, 2024 Category: Toxicology Authors: Perumal Vivekanandhan Sulaiman Ali Alharbi Mohammad Javed Ansari Source Type: research
Exploration of beauvericin's toxic effects and mechanisms in human astrocytes and N-acetylcysteine's protective role
In conclusion, our findings suggest that BEA-induced cytotoxicity in GHA cells involves oxidative stress-associated apoptosis. Furthermore, NAC demonstrates potential as a protective agent against BEA-induced oxidative damage.PMID:38670497 | DOI:10.1016/j.toxicon.2024.107734 (Source: Toxicon)
Source: Toxicon - April 26, 2024 Category: Toxicology Authors: Wei-Zhe Liang Yuan-Yi Chia Huai-Jhih Sun Gwo-Ching Sun Source Type: research
Lepiota castanea mushroom growing in Turkiye does not contain phallotoxins and amatoxins
This study aimed to demonstrate the toxin levels of L. castanea collected from forests in different regions of Turkiye (Istanbul and Kocaeli) using sensitive methods. The collected mushrooms were analyzed for alpha amanitin, beta amanitin, gamma amanitin, amanin, phallacidin, and phalloidin levels using RP-HPLC-UV and LC-ESI-MS/MS methods. L. castanea mushroom was found to be free of amatoxin and phallotoxin. Our study revealed for the first time that L. castanea mushrooms from different geographical regions of Turkiye do not contain amatoxin and phallotoxin. Supporting these findings with new studies from different parts ...
Source: Toxicon - April 26, 2024 Category: Toxicology Authors: Ismail Yilmaz Ilgaz Akata Ersan Horoz Ertugrul Kaya Source Type: research
Identification of a homoarginine biosynthetic gene from a microcystin biosynthetic pathway
This study provides new insights into the logic underpinning the biosynthesis of microcystin chemical variants and broadens our knowledge of structural diversity of microcystins.PMID:38670499 | DOI:10.1016/j.toxicon.2024.107733 (Source: Toxicon)
Source: Toxicon - April 26, 2024 Category: Toxicology Authors: Xiaodan Ouyang Matti Wahlsten Maija Pollari Endrews Delbaje Jouni Jokela David P Fewer Source Type: research
T-2 toxin-induced damage to articular cartilage in rats coincided with impaired autophagy linked to the HIF-1 α/AMPK signaling axis
This study offers novel insights into the precise mechanism underlying T-2 toxin-induced damage to articular cartilage.PMID:38670500 | DOI:10.1016/j.toxicon.2024.107735 (Source: Toxicon)
Source: Toxicon - April 26, 2024 Category: Toxicology Authors: Fang Qi Si-Lu Cui Bing Zhang Hao-Nan Li Jun Yu Source Type: research
Exploration of beauvericin's toxic effects and mechanisms in human astrocytes and N-acetylcysteine's protective role
In conclusion, our findings suggest that BEA-induced cytotoxicity in GHA cells involves oxidative stress-associated apoptosis. Furthermore, NAC demonstrates potential as a protective agent against BEA-induced oxidative damage.PMID:38670497 | DOI:10.1016/j.toxicon.2024.107734 (Source: Toxicon)
Source: Toxicon - April 26, 2024 Category: Toxicology Authors: Wei-Zhe Liang Yuan-Yi Chia Huai-Jhih Sun Gwo-Ching Sun Source Type: research
Lepiota castanea mushroom growing in Turkiye does not contain phallotoxins and amatoxins
This study aimed to demonstrate the toxin levels of L. castanea collected from forests in different regions of Turkiye (Istanbul and Kocaeli) using sensitive methods. The collected mushrooms were analyzed for alpha amanitin, beta amanitin, gamma amanitin, amanin, phallacidin, and phalloidin levels using RP-HPLC-UV and LC-ESI-MS/MS methods. L. castanea mushroom was found to be free of amatoxin and phallotoxin. Our study revealed for the first time that L. castanea mushrooms from different geographical regions of Turkiye do not contain amatoxin and phallotoxin. Supporting these findings with new studies from different parts ...
Source: Toxicon - April 26, 2024 Category: Toxicology Authors: Ismail Yilmaz Ilgaz Akata Ersan Horoz Ertugrul Kaya Source Type: research
Identification of a homoarginine biosynthetic gene from a microcystin biosynthetic pathway
This study provides new insights into the logic underpinning the biosynthesis of microcystin chemical variants and broadens our knowledge of structural diversity of microcystins.PMID:38670499 | DOI:10.1016/j.toxicon.2024.107733 (Source: Toxicon)
Source: Toxicon - April 26, 2024 Category: Toxicology Authors: Xiaodan Ouyang Matti Wahlsten Maija Pollari Endrews Delbaje Jouni Jokela David P Fewer Source Type: research
T-2 toxin-induced damage to articular cartilage in rats coincided with impaired autophagy linked to the HIF-1 α/AMPK signaling axis
This study offers novel insights into the precise mechanism underlying T-2 toxin-induced damage to articular cartilage.PMID:38670500 | DOI:10.1016/j.toxicon.2024.107735 (Source: Toxicon)
Source: Toxicon - April 26, 2024 Category: Toxicology Authors: Fang Qi Si-Lu Cui Bing Zhang Hao-Nan Li Jun Yu Source Type: research
Microcystin-LR Improves Anti-Tumor Efficacy of Oxaliplatin through Induction of M1 Macrophage Polarization
In this study, we used microcystin-LR (MC-LR), a cyclic heptapeptide produced by cyanobacteria, to induce in vitro macrophage innate immunity and transition into the anti-tumor M1 phenotype. MC-LR was also tested in vivo in a mouse model of colorectal cancer. An intraperitoneal injection of MC-LR increased the proportion of CD86⁺ M1 macrophages and triggered the maturation of CD11c⁺ dendritic cells within tumor tissues. MC-LR combined with the chemotherapeutic drug oxaliplatin significantly inhibited tumor growth in vivo. Flow cytometry analysis revealed increased infiltration of activated cytotoxic (CD8⁺, PD-1⁺) T...
Source: Toxicon - April 25, 2024 Category: Toxicology Authors: Li Keyi Minzhu Yang Yuxin Dai Jinyan Huang Peng Zhu Liu Qiuzhen Source Type: research
Sophorin mitigate flutamide-induced hepatotoxicity in Wistar rats
In this study,sophorin was used at a dose of 100mg/kg body weight in purified water via oral route for 4 week daily whereas, flutamide was used at a dose of 100mg kg/b.wt for 4 weeks daily in 0.5% carboxy methyl cellulose (CMC) through the oral route for the induction of hepatotoxicity. Flutamide administration leads to enhanced reactive oxygen species (ROS) generation, an imbalance in redox homeostasis and peroxidation of lipid resulted in reduced natural antioxidant level in liver tissue. Our result demonstrated that sophorin significantly abrogate flutamide induced lipid peroxidation, protein carbonyl (PC), and also sig...
Source: Toxicon - April 23, 2024 Category: Toxicology Authors: Rishi Sharma Md Meraj Ansari Manzar Alam Mohammad Fareed Nemat Ali Anas Ahmad Sarwat Sultana Rehan Khan Source Type: research
