Modulation of host immunity by sensory neurons
Trends Immunol. 2024 May 1:S1471-4906(24)00063-2. doi: 10.1016/j.it.2024.03.005. Online ahead of print.ABSTRACTRecent studies have uncovered a new role for sensory neurons in influencing mammalian host immunity, challenging conventional notions of the nervous and immune systems as separate entities. In this review we delve into this groundbreaking paradigm of neuroimmunology and discuss recent scientific evidence for the impact of sensory neurons on host responses against a wide range of pathogens and diseases, encompassing microbial infections and cancers. These valuable insights enhance our understanding of the interacti...
Source: Trends in Immunology - May 2, 2024 Category: Allergy & Immunology Authors: Telma Saraiva-Santos Tiago H Zaninelli Felipe A Pinho-Ribeiro Source Type: research
Modulation of host immunity by sensory neurons
Trends Immunol. 2024 May 1:S1471-4906(24)00063-2. doi: 10.1016/j.it.2024.03.005. Online ahead of print.ABSTRACTRecent studies have uncovered a new role for sensory neurons in influencing mammalian host immunity, challenging conventional notions of the nervous and immune systems as separate entities. In this review we delve into this groundbreaking paradigm of neuroimmunology and discuss recent scientific evidence for the impact of sensory neurons on host responses against a wide range of pathogens and diseases, encompassing microbial infections and cancers. These valuable insights enhance our understanding of the interacti...
Source: Trends in Immunology - May 2, 2024 Category: Allergy & Immunology Authors: Telma Saraiva-Santos Tiago H Zaninelli Felipe A Pinho-Ribeiro Source Type: research
Modulation of host immunity by sensory neurons
Trends Immunol. 2024 May 1:S1471-4906(24)00063-2. doi: 10.1016/j.it.2024.03.005. Online ahead of print.ABSTRACTRecent studies have uncovered a new role for sensory neurons in influencing mammalian host immunity, challenging conventional notions of the nervous and immune systems as separate entities. In this review we delve into this groundbreaking paradigm of neuroimmunology and discuss recent scientific evidence for the impact of sensory neurons on host responses against a wide range of pathogens and diseases, encompassing microbial infections and cancers. These valuable insights enhance our understanding of the interacti...
Source: Trends in Immunology - May 2, 2024 Category: Allergy & Immunology Authors: Telma Saraiva-Santos Tiago H Zaninelli Felipe A Pinho-Ribeiro Source Type: research
Partners and guardians of the nervous and immune systems
Trends Immunol. 2024 Apr 30:S1471-4906(24)00076-0. doi: 10.1016/j.it.2024.04.007. Online ahead of print.NO ABSTRACTPMID:38692936 | DOI:10.1016/j.it.2024.04.007 (Source: Trends in Immunology)
Source: Trends in Immunology - May 1, 2024 Category: Allergy & Immunology Authors: Catarina Sacrist án Source Type: research
Partners and guardians of the nervous and immune systems
Trends Immunol. 2024 Apr 30:S1471-4906(24)00076-0. doi: 10.1016/j.it.2024.04.007. Online ahead of print.NO ABSTRACTPMID:38692936 | DOI:10.1016/j.it.2024.04.007 (Source: Trends in Immunology)
Source: Trends in Immunology - May 1, 2024 Category: Allergy & Immunology Authors: Catarina Sacrist án Source Type: research
Embryonic microglia maintain the brain's cortical fault lines
Trends Immunol. 2024 Apr 24:S1471-4906(24)00074-7. doi: 10.1016/j.it.2024.04.005. Online ahead of print.ABSTRACTLawrence et al. report that fetal cortical boundaries are susceptible to morphogenetic stress that regulates a microglia state resembling postnatal, axon-tract associated microglia (ATM). This state performs a newfound function at these boundaries by preventing the formation of cavitary lesions, mediated in part by Spp1-regulated phagocytosis of fibronectin 1.PMID:38664101 | DOI:10.1016/j.it.2024.04.005 (Source: Trends in Immunology)
Source: Trends in Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Anushree S Gupte T Yvanka de Soysa Beth Stevens Source Type: research
Embryonic microglia maintain the brain's cortical fault lines
Trends Immunol. 2024 Apr 24:S1471-4906(24)00074-7. doi: 10.1016/j.it.2024.04.005. Online ahead of print.ABSTRACTLawrence et al. report that fetal cortical boundaries are susceptible to morphogenetic stress that regulates a microglia state resembling postnatal, axon-tract associated microglia (ATM). This state performs a newfound function at these boundaries by preventing the formation of cavitary lesions, mediated in part by Spp1-regulated phagocytosis of fibronectin 1.PMID:38664101 | DOI:10.1016/j.it.2024.04.005 (Source: Trends in Immunology)
Source: Trends in Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Anushree S Gupte T Yvanka de Soysa Beth Stevens Source Type: research
Embryonic microglia maintain the brain's cortical fault lines
Trends Immunol. 2024 Apr 24:S1471-4906(24)00074-7. doi: 10.1016/j.it.2024.04.005. Online ahead of print.ABSTRACTLawrence et al. report that fetal cortical boundaries are susceptible to morphogenetic stress that regulates a microglia state resembling postnatal, axon-tract associated microglia (ATM). This state performs a newfound function at these boundaries by preventing the formation of cavitary lesions, mediated in part by Spp1-regulated phagocytosis of fibronectin 1.PMID:38664101 | DOI:10.1016/j.it.2024.04.005 (Source: Trends in Immunology)
Source: Trends in Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Anushree S Gupte T Yvanka de Soysa Beth Stevens Source Type: research
Embryonic microglia maintain the brain's cortical fault lines
Trends Immunol. 2024 Apr 24:S1471-4906(24)00074-7. doi: 10.1016/j.it.2024.04.005. Online ahead of print.ABSTRACTLawrence et al. report that fetal cortical boundaries are susceptible to morphogenetic stress that regulates a microglia state resembling postnatal, axon-tract associated microglia (ATM). This state performs a newfound function at these boundaries by preventing the formation of cavitary lesions, mediated in part by Spp1-regulated phagocytosis of fibronectin 1.PMID:38664101 | DOI:10.1016/j.it.2024.04.005 (Source: Trends in Immunology)
Source: Trends in Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Anushree S Gupte T Yvanka de Soysa Beth Stevens Source Type: research
Embryonic microglia maintain the brain's cortical fault lines
Trends Immunol. 2024 Apr 24:S1471-4906(24)00074-7. doi: 10.1016/j.it.2024.04.005. Online ahead of print.ABSTRACTLawrence et al. report that fetal cortical boundaries are susceptible to morphogenetic stress that regulates a microglia state resembling postnatal, axon-tract associated microglia (ATM). This state performs a newfound function at these boundaries by preventing the formation of cavitary lesions, mediated in part by Spp1-regulated phagocytosis of fibronectin 1.PMID:38664101 | DOI:10.1016/j.it.2024.04.005 (Source: Trends in Immunology)
Source: Trends in Immunology - April 25, 2024 Category: Allergy & Immunology Authors: Anushree S Gupte T Yvanka de Soysa Beth Stevens Source Type: research
Bridging anatomical gaps between brain and immune system
Trends Immunol. 2024 Apr 23:S1471-4906(24)00075-9. doi: 10.1016/j.it.2024.04.006. Online ahead of print.ABSTRACTIt is increasingly clear that the central nervous system (CNS) relies significantly on both adaptive and innate immune cells for its repair and lifelong maintenance. These interactions hold profound implications for brain aging and neurodegeneration. Recent work by Smyth et al. describes newfound anatomical connections between the brain and dura mater, which they named the arachnoid cuff exit points.PMID:38658220 | DOI:10.1016/j.it.2024.04.006 (Source: Trends in Immunology)
Source: Trends in Immunology - April 24, 2024 Category: Allergy & Immunology Authors: Giulia Castellani Javier Mar ía Peralta Ramos Michal Schwartz Source Type: research
Microglia as integrators of brain-associated molecular patterns
Trends Immunol. 2024 Apr 23:S1471-4906(24)00067-X. doi: 10.1016/j.it.2024.03.009. Online ahead of print.ABSTRACTMicroglia are brain-resident macrophages that play key roles in brain development and experience dependent plasticity. In this review we discuss recent findings regarding the molecular mechanisms through which mammalian microglia sense the unique molecular patterns of the homeostatic brain. We propose that microglial function is acutely controlled in response to 'brain-associated molecular patterns' (BAMPs) that function as indicators of neuronal activity and neural circuit remodeling. A further layer of regulati...
Source: Trends in Immunology - April 24, 2024 Category: Allergy & Immunology Authors: Caroline C Escoubas Anna V Molofsky Source Type: research
Bridging anatomical gaps between brain and immune system
Trends Immunol. 2024 Apr 23:S1471-4906(24)00075-9. doi: 10.1016/j.it.2024.04.006. Online ahead of print.ABSTRACTIt is increasingly clear that the central nervous system (CNS) relies significantly on both adaptive and innate immune cells for its repair and lifelong maintenance. These interactions hold profound implications for brain aging and neurodegeneration. Recent work by Smyth et al. describes newfound anatomical connections between the brain and dura mater, which they named the arachnoid cuff exit points.PMID:38658220 | DOI:10.1016/j.it.2024.04.006 (Source: Trends in Immunology)
Source: Trends in Immunology - April 24, 2024 Category: Allergy & Immunology Authors: Giulia Castellani Javier Mar ía Peralta Ramos Michal Schwartz Source Type: research
Microglia as integrators of brain-associated molecular patterns
Trends Immunol. 2024 Apr 23:S1471-4906(24)00067-X. doi: 10.1016/j.it.2024.03.009. Online ahead of print.ABSTRACTMicroglia are brain-resident macrophages that play key roles in brain development and experience dependent plasticity. In this review we discuss recent findings regarding the molecular mechanisms through which mammalian microglia sense the unique molecular patterns of the homeostatic brain. We propose that microglial function is acutely controlled in response to 'brain-associated molecular patterns' (BAMPs) that function as indicators of neuronal activity and neural circuit remodeling. A further layer of regulati...
Source: Trends in Immunology - April 24, 2024 Category: Allergy & Immunology Authors: Caroline C Escoubas Anna V Molofsky Source Type: research
Sensory neuronal control of skin barrier immunity
Trends Immunol. 2024 Apr 22:S1471-4906(24)00066-8. doi: 10.1016/j.it.2024.03.008. Online ahead of print.ABSTRACTPeripheral sensory neurons recognize diverse noxious stimuli, including microbial products and allergens traditionally thought to be targets of the mammalian immune system. Activation of sensory neurons by these stimuli leads to pain and itch responses as well as the release of neuropeptides that interact with their cognate receptors expressed on immune cells, such as dendritic cells (DCs). Neuronal control of immune cell function through neuropeptide release not only affects local inflammatory responses but can ...
Source: Trends in Immunology - April 23, 2024 Category: Allergy & Immunology Authors: Xinyi Feng Haoting Zhan Caroline L Sokol Source Type: research
