Ancestry, ethnicity, and race: explaining inequalities in cardiometabolic disease
Trends Mol Med. 2024 Apr 26:S1471-4914(24)00090-X. doi: 10.1016/j.molmed.2024.04.002. Online ahead of print.ABSTRACTPopulation differences in cardiometabolic disease remain unexplained. Misleading assumptions over genetic explanations are partly due to terminology used to distinguish populations, specifically ancestry, race, and ethnicity. These terms differentially implicate environmental and biological causal pathways, which should inform their use. Genetic variation alone accounts for a limited fraction of population differences in cardiometabolic disease. Research effort should focus on societally driven, lifelong envi...
Source: Trends in Molecular Medicine - April 27, 2024 Category: Molecular Biology Authors: S V Eastwood G Hemani S H Watkins A Scally G Davey Smith N Chaturvedi Source Type: research
Ancestry, ethnicity, and race: explaining inequalities in cardiometabolic disease
Trends Mol Med. 2024 Apr 26:S1471-4914(24)00090-X. doi: 10.1016/j.molmed.2024.04.002. Online ahead of print.ABSTRACTPopulation differences in cardiometabolic disease remain unexplained. Misleading assumptions over genetic explanations are partly due to terminology used to distinguish populations, specifically ancestry, race, and ethnicity. These terms differentially implicate environmental and biological causal pathways, which should inform their use. Genetic variation alone accounts for a limited fraction of population differences in cardiometabolic disease. Research effort should focus on societally driven, lifelong envi...
Source: Trends in Molecular Medicine - April 27, 2024 Category: Molecular Biology Authors: S V Eastwood G Hemani S H Watkins A Scally G Davey Smith N Chaturvedi Source Type: research
Educate, not kill: treating cancer without triggering its defenses
Trends Mol Med. 2024 Apr 23:S1471-4914(24)00091-1. doi: 10.1016/j.molmed.2024.04.003. Online ahead of print.ABSTRACTTraditionally, anticancer therapies focus on restraining uncontrolled proliferation. However, these cytotoxic therapies expose cancer cells to direct killing, instigating the process of natural selection favoring survival of resistant cells that become the foundation for tumor progression and therapy failure. Recognizing this phenomenon has prompted the development of alternative therapeutic strategies. Here we propose strategies targeting cancer hallmarks beyond proliferation, aiming at re-educating cancer c...
Source: Trends in Molecular Medicine - April 24, 2024 Category: Molecular Biology Authors: Aneta Škarková Mariano Bizzarri Radoslav Jano štiak Jan Ma šek Daniel Rosel Jan Br ábek Source Type: research
Educate, not kill: treating cancer without triggering its defenses
Trends Mol Med. 2024 Apr 23:S1471-4914(24)00091-1. doi: 10.1016/j.molmed.2024.04.003. Online ahead of print.ABSTRACTTraditionally, anticancer therapies focus on restraining uncontrolled proliferation. However, these cytotoxic therapies expose cancer cells to direct killing, instigating the process of natural selection favoring survival of resistant cells that become the foundation for tumor progression and therapy failure. Recognizing this phenomenon has prompted the development of alternative therapeutic strategies. Here we propose strategies targeting cancer hallmarks beyond proliferation, aiming at re-educating cancer c...
Source: Trends in Molecular Medicine - April 24, 2024 Category: Molecular Biology Authors: Aneta Škarková Mariano Bizzarri Radoslav Jano štiak Jan Ma šek Daniel Rosel Jan Br ábek Source Type: research
Educate, not kill: treating cancer without triggering its defenses
Trends Mol Med. 2024 Apr 23:S1471-4914(24)00091-1. doi: 10.1016/j.molmed.2024.04.003. Online ahead of print.ABSTRACTTraditionally, anticancer therapies focus on restraining uncontrolled proliferation. However, these cytotoxic therapies expose cancer cells to direct killing, instigating the process of natural selection favoring survival of resistant cells that become the foundation for tumor progression and therapy failure. Recognizing this phenomenon has prompted the development of alternative therapeutic strategies. Here we propose strategies targeting cancer hallmarks beyond proliferation, aiming at re-educating cancer c...
Source: Trends in Molecular Medicine - April 24, 2024 Category: Molecular Biology Authors: Aneta Škarková Mariano Bizzarri Radoslav Jano štiak Jan Ma šek Daniel Rosel Jan Br ábek Source Type: research
HDAC inhibitors as pharmacological treatment for Duchenne muscular dystrophy: a discovery journey from bench to patients: (Trends in Molecular Medicine, 30:3 p:278-294, 2024)
Trends Mol Med. 2024 Apr 19:S1471-4914(24)00084-4. doi: 10.1016/j.molmed.2024.03.012. Online ahead of print.NO ABSTRACTPMID:38643051 | DOI:10.1016/j.molmed.2024.03.012 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - April 20, 2024 Category: Molecular Biology Authors: Chiara Mozzetta Vittorio Sartorelli Christian Steinkuhler Pier Lorenzo Puri Source Type: research
HDAC inhibitors as pharmacological treatment for Duchenne muscular dystrophy: a discovery journey from bench to patients: (Trends in Molecular Medicine, 30:3 p:278-294, 2024)
Trends Mol Med. 2024 Apr 19:S1471-4914(24)00084-4. doi: 10.1016/j.molmed.2024.03.012. Online ahead of print.NO ABSTRACTPMID:38643051 | DOI:10.1016/j.molmed.2024.03.012 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - April 20, 2024 Category: Molecular Biology Authors: Chiara Mozzetta Vittorio Sartorelli Christian Steinkuhler Pier Lorenzo Puri Source Type: research
Science around the world
Trends Mol Med. 2024 Apr 17:S1471-4914(24)00066-2. doi: 10.1016/j.molmed.2024.03.011. Online ahead of print.NO ABSTRACTPMID:38637175 | DOI:10.1016/j.molmed.2024.03.011 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Sarah J Annesley Serkan Kir Yang Liu Alankrita Rani Source Type: research
Science around the world
Trends Mol Med. 2024 Apr 17:S1471-4914(24)00066-2. doi: 10.1016/j.molmed.2024.03.011. Online ahead of print.NO ABSTRACTPMID:38637175 | DOI:10.1016/j.molmed.2024.03.011 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Sarah J Annesley Serkan Kir Yang Liu Alankrita Rani Source Type: research
Harnessing gastrointestinal organoids for cancer therapy
Trends Mol Med. 2024 Apr 13:S1471-4914(24)00065-0. doi: 10.1016/j.molmed.2024.03.010. Online ahead of print.ABSTRACTGastrointestinal organoids have emerged as a model system that authentically recapitulates the in vivo situation. Despite biomedical and technical challenges, self-assembled 3D structures derived from pluripotent stem cells or healthy and diseased tissues have proved to be invaluable tools for cancer drug discovery, disease modeling, and studying infection with carcinogenic pathogens.PMID:38616435 | DOI:10.1016/j.molmed.2024.03.010 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - April 15, 2024 Category: Molecular Biology Authors: Gunter Maubach Michael Naumann Source Type: research
Harnessing gastrointestinal organoids for cancer therapy
Trends Mol Med. 2024 Apr 13:S1471-4914(24)00065-0. doi: 10.1016/j.molmed.2024.03.010. Online ahead of print.ABSTRACTGastrointestinal organoids have emerged as a model system that authentically recapitulates the in vivo situation. Despite biomedical and technical challenges, self-assembled 3D structures derived from pluripotent stem cells or healthy and diseased tissues have proved to be invaluable tools for cancer drug discovery, disease modeling, and studying infection with carcinogenic pathogens.PMID:38616435 | DOI:10.1016/j.molmed.2024.03.010 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - April 15, 2024 Category: Molecular Biology Authors: Gunter Maubach Michael Naumann Source Type: research
Eating disorders - enemies of the body and mind
Trends Mol Med. 2024 Apr;30(4):295-296. doi: 10.1016/j.molmed.2024.02.014.NO ABSTRACTPMID:38604129 | DOI:10.1016/j.molmed.2024.02.014 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - April 11, 2024 Category: Molecular Biology Authors: Aliki Perdikari Source Type: research
Exploiting pancreatic cancer metabolism: challenges and opportunities
Trends Mol Med. 2024 Apr 10:S1471-4914(24)00063-7. doi: 10.1016/j.molmed.2024.03.008. Online ahead of print.ABSTRACTPancreatic ductal adenocarcinoma (PDAC) is a highly aggressive form of pancreatic cancer, known for its challenging diagnosis and limited treatment options. The focus on metabolic reprogramming as a key factor in tumor initiation, progression, and therapy resistance has gained prominence. In this review we focus on the impact of metabolic changes on the interplay among stromal, immune, and tumor cells, as glutamine and branched-chain amino acids (BCAAs) emerge as pivotal players in modulating immune cell func...
Source: Trends in Molecular Medicine - April 11, 2024 Category: Molecular Biology Authors: Maria Chiara De Santis B Bockorny E Hirsch P Cappello M Martini Source Type: research
Eating disorders - enemies of the body and mind
Trends Mol Med. 2024 Apr;30(4):295-296. doi: 10.1016/j.molmed.2024.02.014.NO ABSTRACTPMID:38604129 | DOI:10.1016/j.molmed.2024.02.014 (Source: Trends in Molecular Medicine)
Source: Trends in Molecular Medicine - April 11, 2024 Category: Molecular Biology Authors: Aliki Perdikari Source Type: research
Exploiting pancreatic cancer metabolism: challenges and opportunities
Trends Mol Med. 2024 Apr 10:S1471-4914(24)00063-7. doi: 10.1016/j.molmed.2024.03.008. Online ahead of print.ABSTRACTPancreatic ductal adenocarcinoma (PDAC) is a highly aggressive form of pancreatic cancer, known for its challenging diagnosis and limited treatment options. The focus on metabolic reprogramming as a key factor in tumor initiation, progression, and therapy resistance has gained prominence. In this review we focus on the impact of metabolic changes on the interplay among stromal, immune, and tumor cells, as glutamine and branched-chain amino acids (BCAAs) emerge as pivotal players in modulating immune cell func...
Source: Trends in Molecular Medicine - April 11, 2024 Category: Molecular Biology Authors: Maria Chiara De Santis B Bockorny E Hirsch P Cappello M Martini Source Type: research
