Editorial: Recent advances in plant virology
Virology. 2024 Apr 25;595:110099. doi: 10.1016/j.virol.2024.110099. Online ahead of print.NO ABSTRACTPMID:38701717 | DOI:10.1016/j.virol.2024.110099 (Source: Virology)
Source: Virology - May 3, 2024 Category: Virology Authors: Fangfang Li Zongtao Sun Xueping Zhou Source Type: research
Porcine reproductive and respiratory syndrome virus nsp4-mediated β2M downregulation contributes to SLA-I decrease and virus infection in vivo and in vitro
Virology. 2024 Apr 26;595:110083. doi: 10.1016/j.virol.2024.110083. Online ahead of print.ABSTRACTPorcine reproductive and respiratory syndrome virus (PRRSV) infection inhibits swine leukocyte antigen class I (SLA-I) expression in pigs, resulting in inefficient antigen presentation and subsequent low levels of cellular PRRSV-specific immunity as well as persistent viremia. We previously observed that the non-structural protein 4 (nsp4) of PRRSV contributed to inhibition of the β2-microglobulin (β2M) and SLA-I expression in cells. Here, we constructed a series of nsp4 mutants with different combination of amino acid mutat...
Source: Virology - May 2, 2024 Category: Virology Authors: Lei Kang Abdul Wahaab Pengfei Qi Yafeng Qiu Jianchao Wei Beibei Li Donghua Shao Zongjie Li Ke Liu Zhiyong Ma Shuo Su Source Type: research
Porcine reproductive and respiratory syndrome virus nsp4-mediated β2M downregulation contributes to SLA-I decrease and virus infection in vivo and in vitro
Virology. 2024 Apr 26;595:110083. doi: 10.1016/j.virol.2024.110083. Online ahead of print.ABSTRACTPorcine reproductive and respiratory syndrome virus (PRRSV) infection inhibits swine leukocyte antigen class I (SLA-I) expression in pigs, resulting in inefficient antigen presentation and subsequent low levels of cellular PRRSV-specific immunity as well as persistent viremia. We previously observed that the non-structural protein 4 (nsp4) of PRRSV contributed to inhibition of the β2-microglobulin (β2M) and SLA-I expression in cells. Here, we constructed a series of nsp4 mutants with different combination of amino acid mutat...
Source: Virology - May 2, 2024 Category: Virology Authors: Lei Kang Abdul Wahaab Pengfei Qi Yafeng Qiu Jianchao Wei Beibei Li Donghua Shao Zongjie Li Ke Liu Zhiyong Ma Shuo Su Source Type: research
E-M349E and NS2A/2B-P1(T) are compensatory mutations of rDTMUV-NS2AB-P1P1'(AA), which regain virus proliferation by enhancing the virus package and restoring NS2A/2B cleavage
In this study, we investigate the effects of the P1P1' (AA) mutation on the viral life cycle and explore compensatory mutations in rDTMUV-NS2A/2B-P1P1' (AA). Infected ducklings exhibit similar body weight gain and viral tissue loads to DTMUV-WT. Compensatory mutations E-M349E and P1(T) emerge, restoring proliferation levels to those of rDTMUV-WT. Specifically, E-M349E enhances viral packaging, while P1(T) reinstates NS2A/2B proteolysis in vitro. Thus, our findings reveal novel compensatory sites capable of restoring the attenuated DTMUV during polyprotein cleavage and packaging.PMID:38692132 | DOI:10.1016/j.virol.2024.1100...
Source: Virology - May 1, 2024 Category: Virology Authors: Bowen Jiang Wei Zhang Tao Hu Yu He Zhen Wu Mingshu Wang Renyong Jia Dekang Zhu Mafeng Liu Xinxin Zhao Qiao Yang Ying Wu Shaqiu Zhang Juan Huang Sai Mao Xumin Ou Di Sun Ling Zhang YanLing Yu Xin Pan Jingyi Zhong Anchun Cheng Shun Chen Source Type: research
miR-214-PTEN pathway is a potential mechanism for stress-induced immunosuppression affecting chicken immune response to avian influenza virus vaccine
This study can provide references for further understanding of stress affecting immune response.PMID:38692133 | DOI:10.1016/j.virol.2024.110094 (Source: Virology)
Source: Virology - May 1, 2024 Category: Virology Authors: Xiaoli Ma Qiuyuan Wang Xinxin Xu Wei Zhang Rui Zhang Yi Jiang Xiangnan Wang Chaolai Man Source Type: research
VP5 protein of oncolytic herpes simplex virus type 2 induces apoptosis in A549 cells through TP53I3 protein
Virology. 2024 Apr 25;595:110093. doi: 10.1016/j.virol.2024.110093. Online ahead of print.ABSTRACTOncolytic virotherapy stands out as a burgeoning and promising therapeutic paradigm, harnessing the intrinsic cytotoxicity of oncolytic viruses for selective replication and dissemination within tumors. The primary mode of action revolves around the direct eradication of tumor cells. In our previous investigations, we formulated an oncolytic herpes simplex virus type 2 (OH2) and substantiated its anti-tumor efficacy both in vivo and in vitro. Subsequently, we embarked on a phase I/II clinical trial in China (NMPA, 2018L02743) ...
Source: Virology - May 1, 2024 Category: Virology Authors: Yang Wang Hui Zhang Qin Zhou Wen Xia Xiaotong Zhao Le Li Xinya Wang Jingru Yang Xinxin Ren Jian Wu Han Hu Binlei Liu Source Type: research
Cross-protection against influenza viruses by chimeric M2e-H3 stalk protein or multi-subtype neuraminidase plus M2e virus-like particle vaccine in ferrets
Virology. 2024 Apr 25;595:110097. doi: 10.1016/j.virol.2024.110097. Online ahead of print.ABSTRACTCurrent influenza vaccine is not effective in providing cross-protection against variants. We evaluated the immunogenicity and efficacy of multi-subtype neuraminidase (NA) and M2 ectodomain virus-like particle (m-cNA-M2e VLP) and chimeric M2e-H3 stalk protein vaccines (M2e-H3 stalk) in ferrets. Our results showed that ferrets with recombinant m-cNA-M2e VLP or M2e-H3 stalk vaccination induced multi-vaccine antigen specific IgG antibodies (M2e, H3 stalk, NA), NA inhibition, antibody-secreting cells, and IFN-γ secreting cell res...
Source: Virology - April 30, 2024 Category: Virology Authors: Ki-Hye Kim Noopur Bhatnagar Jeeva Subbiah Rong Liu Surya Sekhar Pal Jannatul Ruhan Raha Phillip Grovenstein Chong Hyun Shin Bao-Zhong Wang Sang-Moo Kang Source Type: research
Cross-protection against influenza viruses by chimeric M2e-H3 stalk protein or multi-subtype neuraminidase plus M2e virus-like particle vaccine in ferrets
Virology. 2024 Apr 25;595:110097. doi: 10.1016/j.virol.2024.110097. Online ahead of print.ABSTRACTCurrent influenza vaccine is not effective in providing cross-protection against variants. We evaluated the immunogenicity and efficacy of multi-subtype neuraminidase (NA) and M2 ectodomain virus-like particle (m-cNA-M2e VLP) and chimeric M2e-H3 stalk protein vaccines (M2e-H3 stalk) in ferrets. Our results showed that ferrets with recombinant m-cNA-M2e VLP or M2e-H3 stalk vaccination induced multi-vaccine antigen specific IgG antibodies (M2e, H3 stalk, NA), NA inhibition, antibody-secreting cells, and IFN-γ secreting cell res...
Source: Virology - April 30, 2024 Category: Virology Authors: Ki-Hye Kim Noopur Bhatnagar Jeeva Subbiah Rong Liu Surya Sekhar Pal Jannatul Ruhan Raha Phillip Grovenstein Chong Hyun Shin Bao-Zhong Wang Sang-Moo Kang Source Type: research
Cross-protection against influenza viruses by chimeric M2e-H3 stalk protein or multi-subtype neuraminidase plus M2e virus-like particle vaccine in ferrets
Virology. 2024 Apr 25;595:110097. doi: 10.1016/j.virol.2024.110097. Online ahead of print.ABSTRACTCurrent influenza vaccine is not effective in providing cross-protection against variants. We evaluated the immunogenicity and efficacy of multi-subtype neuraminidase (NA) and M2 ectodomain virus-like particle (m-cNA-M2e VLP) and chimeric M2e-H3 stalk protein vaccines (M2e-H3 stalk) in ferrets. Our results showed that ferrets with recombinant m-cNA-M2e VLP or M2e-H3 stalk vaccination induced multi-vaccine antigen specific IgG antibodies (M2e, H3 stalk, NA), NA inhibition, antibody-secreting cells, and IFN-γ secreting cell res...
Source: Virology - April 30, 2024 Category: Virology Authors: Ki-Hye Kim Noopur Bhatnagar Jeeva Subbiah Rong Liu Surya Sekhar Pal Jannatul Ruhan Raha Phillip Grovenstein Chong Hyun Shin Bao-Zhong Wang Sang-Moo Kang Source Type: research
Ssc-miR-7139-3p suppresses foot-and-mouth disease virus replication by promoting degradation of 3C < sup > pro < /sup > through targeting apoptosis-negative regulatory gene Bcl-2
Virology. 2024 Apr 16;595:110070. doi: 10.1016/j.virol.2024.110070. Online ahead of print.ABSTRACTFoot-and-mouth disease is a highly contagious and infectious disease affecting cloven-hoofed animals. Disease control is complicated by its highly contagious nature and antigenic diversity. Host microRNAs (miRNAs) are post-transcriptional regulators that either promote or repress viral replications in virus infection. In the present study, we found that ssc-miR-7139-3p (Sus scrofa miR-7139-3p) was significantly up-regulated in host cells during foot-and-mouth disease virus (FMDV) infection. Overexpression of miR-7139-3p attenu...
Source: Virology - April 24, 2024 Category: Virology Authors: Kailing Wang Xiangwei Wang Guangxiang Wang Tadele Berihun Afera Shitong Hou Kaishen Yao Jie Zhang Shasha Wang Yuefeng Sun Source Type: research
Ssc-miR-7139-3p suppresses foot-and-mouth disease virus replication by promoting degradation of 3C < sup > pro < /sup > through targeting apoptosis-negative regulatory gene Bcl-2
Virology. 2024 Apr 16;595:110070. doi: 10.1016/j.virol.2024.110070. Online ahead of print.ABSTRACTFoot-and-mouth disease is a highly contagious and infectious disease affecting cloven-hoofed animals. Disease control is complicated by its highly contagious nature and antigenic diversity. Host microRNAs (miRNAs) are post-transcriptional regulators that either promote or repress viral replications in virus infection. In the present study, we found that ssc-miR-7139-3p (Sus scrofa miR-7139-3p) was significantly up-regulated in host cells during foot-and-mouth disease virus (FMDV) infection. Overexpression of miR-7139-3p attenu...
Source: Virology - April 24, 2024 Category: Virology Authors: Kailing Wang Xiangwei Wang Guangxiang Wang Tadele Berihun Afera Shitong Hou Kaishen Yao Jie Zhang Shasha Wang Yuefeng Sun Source Type: research
Ssc-miR-7139-3p suppresses foot-and-mouth disease virus replication by promoting degradation of 3C < sup > pro < /sup > through targeting apoptosis-negative regulatory gene Bcl-2
Virology. 2024 Apr 16;595:110070. doi: 10.1016/j.virol.2024.110070. Online ahead of print.ABSTRACTFoot-and-mouth disease is a highly contagious and infectious disease affecting cloven-hoofed animals. Disease control is complicated by its highly contagious nature and antigenic diversity. Host microRNAs (miRNAs) are post-transcriptional regulators that either promote or repress viral replications in virus infection. In the present study, we found that ssc-miR-7139-3p (Sus scrofa miR-7139-3p) was significantly up-regulated in host cells during foot-and-mouth disease virus (FMDV) infection. Overexpression of miR-7139-3p attenu...
Source: Virology - April 24, 2024 Category: Virology Authors: Kailing Wang Xiangwei Wang Guangxiang Wang Tadele Berihun Afera Shitong Hou Kaishen Yao Jie Zhang Shasha Wang Yuefeng Sun Source Type: research
Ssc-miR-7139-3p suppresses foot-and-mouth disease virus replication by promoting degradation of 3C < sup > pro < /sup > through targeting apoptosis-negative regulatory gene Bcl-2
Virology. 2024 Apr 16;595:110070. doi: 10.1016/j.virol.2024.110070. Online ahead of print.ABSTRACTFoot-and-mouth disease is a highly contagious and infectious disease affecting cloven-hoofed animals. Disease control is complicated by its highly contagious nature and antigenic diversity. Host microRNAs (miRNAs) are post-transcriptional regulators that either promote or repress viral replications in virus infection. In the present study, we found that ssc-miR-7139-3p (Sus scrofa miR-7139-3p) was significantly up-regulated in host cells during foot-and-mouth disease virus (FMDV) infection. Overexpression of miR-7139-3p attenu...
Source: Virology - April 24, 2024 Category: Virology Authors: Kailing Wang Xiangwei Wang Guangxiang Wang Tadele Berihun Afera Shitong Hou Kaishen Yao Jie Zhang Shasha Wang Yuefeng Sun Source Type: research
Neutralization sensitivity of SARS-CoV-2 Omicron variants FL.1 and GE.1 by therapeutic antibodies and XBB sera
In this study, we assessed the neutralizing ability of eleven FDA-approved monoclonal antibody combinations against different Omicron variants, including BA.2.75, BA.2.76, BA.4/5, XBB.1.5, and CH.1.1. Among the eleven antibodies, Sotrovimab was the only antibody to show broad neutralization ability against XBB.1.5. However, Sotrovimab showed attenuated neutralization efficiency against recently emerging XBB sub-lineages EG.5, FL.1, and GE.1 compared to XBB.1.5. Additionally, XBB.1.5 seropositive convalescent sera displayed lower neutralization activity against EG.5, FL.1, and GE.1. Overall, our findings present enhanced im...
Source: Virology - April 23, 2024 Category: Virology Authors: Joseph Lee Youichi Naoe Uikyu Bang Yu Nakagama Akatsuki Saito Yasutoshi Kido Akitsu Hotta Source Type: research
Neutralization sensitivity of SARS-CoV-2 Omicron variants FL.1 and GE.1 by therapeutic antibodies and XBB sera
In this study, we assessed the neutralizing ability of eleven FDA-approved monoclonal antibody combinations against different Omicron variants, including BA.2.75, BA.2.76, BA.4/5, XBB.1.5, and CH.1.1. Among the eleven antibodies, Sotrovimab was the only antibody to show broad neutralization ability against XBB.1.5. However, Sotrovimab showed attenuated neutralization efficiency against recently emerging XBB sub-lineages EG.5, FL.1, and GE.1 compared to XBB.1.5. Additionally, XBB.1.5 seropositive convalescent sera displayed lower neutralization activity against EG.5, FL.1, and GE.1. Overall, our findings present enhanced im...
Source: Virology - April 23, 2024 Category: Virology Authors: Joseph Lee Youichi Naoe Uikyu Bang Yu Nakagama Akatsuki Saito Yasutoshi Kido Akitsu Hotta Source Type: research
