Modulation of Aggregation and Immunogenicity of a Protein: Based on the Study of Hen Lysozyme
This study focuses on the modulation of protein aggregation and immunogenicity. As a starting point for investigating long-range interactions within a non-native protein, the effects of perturbing denatured protein states on their aggregation, including the formation of amyloid fibrils, were evaluated. The effects of adducts, sugar modifications, and stabilization on protein aggregation were then examined. We also investigated how protein immunogenicity was affected by enhancing protein conformational stability and other factors.PMID:38432940 | DOI:10.1248/yakushi.23-00192 (Source: Yakugaku Zasshi : Journal of the Pharmace...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 3, 2024 Category: Drugs & Pharmacology Authors: Tadashi Ueda Source Type: research

Forty-three Years of Dedicated Efforts in Advancing Pharmacist Expertise: Aspiring to Become a Pharmacist and Cultivate Pharmacists Proficient in Recommending Prescription Medicines to Doctors
Yakugaku Zasshi. 2024;144(3):311-328. doi: 10.1248/yakushi.23-00193.ABSTRACTWhen I graduated from university, my aim was to become a pharmacist capable of recommending prescription medicines to doctors and teaching others to do the same. To achieve this goal, I developed comprehensive curricula incorporating progressive educational tools such as problem-based learning and small group discussions. Subsequently, the effectiveness of these tools and curricula was evaluated, and the findings of these assessments were published in various peer-reviewed journal articles. Consequently, a body of evidence on the most effective way...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 3, 2024 Category: Drugs & Pharmacology Authors: Hitomi Teramachi Source Type: research

Validation of the Qualitative Study Findings using Quantitative Analyses on the Current Status of Pharmacists in Home Health Care in Medium-Sized Areas
Yakugaku Zasshi. 2024;144(3):329-338. doi: 10.1248/yakushi.23-00126.ABSTRACTAlthough the issue of home medical care and pharmacists remains widespread, much of the discussion has concentrated on its state in urban areas. We believe that it is necessary to consider the state of home health care in medium-sized regions, that is separate from its urban form, with a population of approximately 100000. Thus, we conducted a qualitative study in Hikone City, Shiga Prefecture, to identify factors that impede pharmacists involved in home medical care. We conducted a questionnaire-based survey in an area of the same size to verify t...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 3, 2024 Category: Drugs & Pharmacology Authors: Kaori Yokomaku Tomohisa Yasuhara Misa Nagata Masahiro Ueda Taro Kushihata Tomomichi Sone Source Type: research

Contribution to Pharmacy/pharmacist Education through Writing
Yakugaku Zasshi. 2024;144(3):243-247. doi: 10.1248/yakushi.23-00182.ABSTRACTThe Education Award of the Pharmaceutical Society of Japan (PSJ) was conferred for "Contribution to pharmacy/pharmacist education through writing on organic chemistry." The award-winning activities were described in three parts section 1-3. Section 1 Importance of Research and Education in Organic Chemistry: In this section, it is explained that organic chemistry serves as the fundamental basis for a wide range of natural science disciplines studied in pharmaceutical departments. It emphasizes that having a solid foundation in organic chemistry is ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 3, 2024 Category: Drugs & Pharmacology Authors: Hideaki Natsugari Source Type: research

Comprehensive Assessment of Cardiovascular Toxicity~From Basic to Clinic~
Yakugaku Zasshi. 2024;144(3):249-250. doi: 10.1248/yakushi.23-00164-F.NO ABSTRACTPMID:38432932 | DOI:10.1248/yakushi.23-00164-F (Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan)
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 3, 2024 Category: Drugs & Pharmacology Authors: Yasunari Kanda Junko Kurokawa Source Type: research