Subject: A novel strategy to inhibit FAK and IGF-1R decreases growth of pancreatic cancer xenografts

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Deregulation of insulin-like growth factor-1 receptor (IGF-1R) and focal adhesion kinase (FAK) signaling pathways plays an important role in cancer cell proliferation and metastasis. In pancreatic cancer cells, the crosstalk and compensatory mechanisms between these two pathways reduce the efficacy of the treatments that target only one of the pathways. Ablation of IGF-1R signaling by siRNA showed minimal effects on the survival and growth of pancreatic cancer cells. An increased activity of FAK pathway was seen in these cells after IGF-1R knockdown. Further inhibition of FAK pathway using Y15 significantly decreased cell ...
Source: Molecular Carcinogenesis - November 3, 2009 Category: Molecular Biology Authors: Donghang Zheng, Vita Golubovskaya, Elena Kurenova, Cheng Wood, Nicole A. Massoll, David Ostrov, William G. Cance, Steven N. Hochwald Source Type: journals