Subject: Inhibition of focal adhesion kinase and src increases detachment and apoptosis in human neuroblastoma cell lines

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Neuroblastoma is the most common extracranial solid tumor of childhood. Focal adhesion kinase (FAK) is an intracellular kinase that is overexpressed in a number of human tumors including neuroblastoma, and regulates both cellular adhesion and survival. We have studied the effects of FAK inhibition upon neuroblastoma using adenovirus-containing FAK-CD (AdFAK-CD). Utilizing an isogenic MYCN+/MYCN- neuroblastoma cell line, we found that the MYCN+ cells are more sensitive to FAK inhibition with AdFAK-CD than their MYCN negative counterparts. In addition, we have shown that phosphorylation of Src is increased in the untreated i...
Source: Molecular Carcinogenesis - November 2, 2009 Category: Molecular Biology Authors: Elizabeth A. Beierle, Xiaojie Ma, Angelica Trujillo, Elena V. Kurenova, William G. Cance, Vita M. Golubovskaya Source Type: journals