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Subject: BH3-only proteins: The death-puppeteer's wires

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Most cell death in vertebrates proceeds through the intrinsic pathway of apoptosis and results from unregulated increase of mitochondrial membrane permeability. Bcl2-associated X protein (Bax) and Bcl2-antagonist/killer protein (Bak), the effector proapoptotic members of the Bcl-2 family, are, in their active state, the principal accomplices for this permeabilization process. How exactly Bax and Bak are activated has been a matter of major investigation in the last decade, and suitable tools offered by quantitative cytometric methodologies have significantly contributed to the understanding of the function of Bcl-2 family ...
Source: Cytometry Part A - November 6, 2009 Category: Molecular Biology Authors: Fabio Ghiotto, Franco Fais, Silvia Bruno Source Type: journals

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