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Subject: Placental growth hormone and growth hormone binding protein are first trimester maternal serum markers of Down syndrome

Subject:

Placental growth hormone and growth hormone binding protein are first trimester maternal serum markers of Down syndromeemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Placental growth hormone (PGH) is synthesised by the placenta, and its function is modulated by growth hormone binding protein (GHBP). The potential of PGH and GHBP as maternal serum screening markers for Down syndrome (DS) was examined.Maternal serum concentrations of PGH and GHBP were determined by ELISA in 74 DS and 261 control pregnancies in gestational week 8+0 to 13+4. Log10 MoM distributions of the markers were established. The performance of DS screening was estimated by Monte Carlo simulation.PGH log10 MoM (SD) was decreased (p < 0.001) to -0.201 (0.373) and GHBP log10 MoM to -0.116 (0.265) (p = 0.04), in DS pregn...
Source: Prenatal Diagnosis - October 20, 2009 Category: Perinatology & Neonatology Authors: Michael Christiansen Source Type: journals

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