Allergy & Immunology
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This page shows you the most recent publications within this specialty of the MedWorm directory.
Discovery Of New Type Of Immune Cells Regulating Inflammation In Chronic Diseases
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The newly discovered Th22 cells are a previously unknown subset of T helper cells. T helper cells are white blood cells that help activate other immune cells when the body is infected by viruses or bacteria. At the same time they help the body to tolerate own tissue and to prevent or curb inflammation. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 21, 2009 Category: Allergy & Immunology Tags: Immune System / Vaccines Source Type: news
Circassia Announces Successful Results From Phase II Clinical Study Of ToleroMune(R) Cat Allergy TherapyEmail this article to a colleague.
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Circassia Ltd, a specialty biopharmaceutical company focused on allergy, announced positive results from a recently completed phase II clinical study of its ToleroMune(R) cat allergy therapy, which successfully identified the optimal dosing regimens to progress into late-stage development. (Source: Allergy News From Medical News Today)
Source: Allergy News From Medical News Today - November 21, 2009 Category: Allergy & Immunology Tags: Allergy Source Type: news
Micro-Endoscope Designed To Seek Out Early Signs Of CancerEmail this article to a colleague.
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Traditional endoscopes provide a peek inside patients' bodies. Now, a University of Florida engineering researcher is designing ones capable of a full inspection. Physicians currently insert camera-equipped endoscopes into patients to hunt visible abnormalities, such as tumors, in the gastrointestinal tract and internal organs. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 21, 2009 Category: Allergy & Immunology Tags: Medical Devices / Diagnostics Source Type: news
Elsevier Journal Vaccine Features Milestone Biodefense PublicationEmail this article to a colleague.
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Last week during the 'Vaccines for Biothreats and Emerging and Neglected Diseases Symposium' in Galveston TX, USA, the Elsevier journal Vaccine released a supplement dedicated to vaccines for biodefense. This publication provides a comprehensive, state-of-the-art overview on vaccines that have been developed against a diverse group of human and veterinary pathogens, including Bacillus anthracis, smallpox, and blue tongue. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 21, 2009 Category: Allergy & Immunology Tags: Immune System / Vaccines Source Type: news
Recommendations for assessing Patient-Reported Outcomes and Health-Related quality of life in clinical trials on allergy: a GA2LEN taskforce position paperEmail this article to a colleague.
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The aim of this Global Allergy and Asthma European Network (GA2LEN) consensus report is to provide recommendations for patient-reported outcomes (PROs) evaluation in clinical trials for allergic diseases, which constitute a global health problem in terms of physical, psychological economic and social impact. During the last 40 years, PROs have gained large consideration and use in the scientific community, to gain a better understanding of patients' subjective assessment with respect to elements concerning their health condition. They include all health-related reports coming from the patient, without involvement or interp...
Source: Allergy - November 21, 2009 Category: Allergy & Immunology Authors: I. Baiardini, P. J. Bousquet, Z. Brzoza, G. W. Canonica, E. Compalati, A. Fiocchi, W. Fokkens, R. G. van Wijk, S. La Grutta, C. Lombardi, M. Maurer, A. M. Pinto, E. Ridolo, G. E. Senna, I. Terreehorst, A. Todo Bom, J. Bousquet, T. Zuberbier, F. Braido Source Type: journals
Does gastric acid suppression increase the risk of drug allergies?Email this article to a colleague.
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(Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - November 21, 2009 Category: Allergy & Immunology Authors: C. Pickard, A. P. Sampson Source Type: journals
Sweet! Sugared Polymer A New Weapon Against Allergies And AsthmaEmail this article to a colleague.
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Scientists at Johns Hopkins and their colleagues have developed sugar-coated polymer strands that selectively kill off cells involved in triggering aggressive allergy and asthma attacks. Their advance is a significant step toward crafting pharmaceuticals to fight these often life-endangering conditions in a new way. For more than a decade, a team led by Bruce S. Bochner, M.D. (Source: Allergy News From Medical News Today)
Source: Allergy News From Medical News Today - November 20, 2009 Category: Allergy & Immunology Tags: Allergy Source Type: news
FDA Panel Finds Tiotropium Safe for COPD PatientsEmail this article to a colleague.
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An FDA committee said new data allay concerns about the risk of stroke and cardiovascular events previously associated with tiotropium (Spiriva), drugmaker Boehringer Ingelheim said. (Source: MedPage Today Allergy)
Source: MedPage Today Allergy - November 20, 2009 Category: Allergy & Immunology Source Type: news
Comment on "TLR9-Dependent Activation of Dendritic Cells by DNA from Leishmania major Favors Th1 Cell Development and the Resolution of Lesions"Email this article to a colleague.
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PMID: 19923471 [PubMed - as supplied by publisher] (Source: Journal of Immunology)
Source: Journal of Immunology - November 20, 2009 Category: Allergy & Immunology Authors: Bogdan C, Schleicher U Tags: J Immunol Source Type: journals
A Crucial Door to the Mast Cell Mystery Knocked In.Email this article to a colleague.
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PMID: 19923472 [PubMed - as supplied by publisher] (Source: Journal of Immunology)
Source: Journal of Immunology - November 20, 2009 Category: Allergy & Immunology Authors: Kawakami T Tags: J Immunol Source Type: journals
Pillars Article: Fate of Bone Marrow-Derived Cultured Mast Cells After Intracutaneous, Intraperitoneal, And Intravenous Transfer Into Genetically Mast Cell-Deficient W/Wv Mice. Evidence That Cultured Mast Cells Can Give Rise To Both Connective Tissue Type And Mucosal Mast Cells. The Journal of Experimental Medicine. 1985. 162: 1025-1043.Email this article to a colleague.
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PMID: 19923473 [PubMed - as supplied by publisher] (Source: Journal of Immunology)
Source: Journal of Immunology - November 20, 2009 Category: Allergy & Immunology Authors: Nakano T, Sonoda T, Hayashi C, Yamatodani A, Kanayama Y, Yamamura TI, Asai H, Yonezawa T, Kitamura Y, Galli SJ Tags: J Immunol Source Type: journals
What Role Does the Route of Immunization Play in the Generation of Protective Immunity against Mucosal Pathogens?Email this article to a colleague.
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The route of vaccination is important in influencing immune responses at the initial site of pathogen invasion where protection is most effective. Immune responses required for mucosal protection can differ vastly depending on the individual pathogen. For some mucosal pathogens, including acute self-limiting infections, high-titer neutralizing Abs that enter tissue parenchyma or transude into the mucosal lumen are sufficient for clearing cell-free virus. However, for pathogens causing chronic infections such as HIV, hepatitis C virus, herpes viruses, mycobacteria, and fungal and parasitic infections, a single arm of th...
Source: Journal of Immunology - November 20, 2009 Category: Allergy & Immunology Authors: Belyakov IM, Ahlers JD Tags: J Immunol Source Type: journals
Beta-2 Receptor Variants Don't Affect LABA Response in Asthma (CME/CE)Email this article to a colleague.
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Against expectations, asthma patients with different genotypes for the beta-2 adrenergic receptor all responded well to long-acting beta agonist (LABA) asthma drugs, researchers said. (Source: MedPage Today Allergy)
Source: MedPage Today Allergy - November 20, 2009 Category: Allergy & Immunology Source Type: news
Potential Strategy To Help Generate HIV-Neutralizing AntibodiesEmail this article to a colleague.
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WHAT: New discoveries about anti-HIV antibodies may bring researchers a step closer to creating an effective HIV vaccine, according to a new paper co-authored by scientists at the Vaccine Research Center of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 20, 2009 Category: Allergy & Immunology Tags: HIV / AIDS Source Type: news
Asthma A Significant Risk Factor For Complications In Children With H1N1Email this article to a colleague.
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A new study on pediatric H1N1 influenza admissions has found that asthma is a significant risk factor for severe disease in children with pandemic H1N1 compared with the seasonal flu. The study (http://www.cmaj.ca/cgi/rapidpdf/cmaj.091724), led by researchers from The Hospital for Sick Children (SickKids) in Toronto, Ontario, is published online in CMAJ (Canadian Medical Association Journal). (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 20, 2009 Category: Allergy & Immunology Tags: Swine Flu Source Type: news
Yale Researchers Target Tick Saliva In Their Search For Lyme DiseaseEmail this article to a colleague.
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A protein found in the saliva of ticks helps protect mice from developing Lyme disease, Yale researchers have discovered. The findings, published in the November 19 issue of Cell Host & Microbe, may spur development of a new vaccine against infection from Lyme disease, which is spread through tick bites. Traditionally, vaccines have directly targeted specific pathogens. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 20, 2009 Category: Allergy & Immunology Tags: Infectious Diseases / Bacteria / Viruses Source Type: news
AFFiRiS AG: Interim Analysis Of Clinical Phase I Data Triggered Decision To Move Alzheimer's Vaccine Candidate AD02 Into Clinical Phase II TestingEmail this article to a colleague.
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AFFiRiS AG will focus its Alzheimer's vaccine program on one product candidate at an unexpectedly early stage of development: the vaccine candidate AD02 is planned to enter into Phase II clinical trial early in 2010. This decision by the company immediately follows the completion of two Phase I trials with the candidates AD01 and AD02. The company based its fast decision on the first interim analysis of the secondary endpoints at the six month time point. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 20, 2009 Category: Allergy & Immunology Tags: Alzheimer's / Dementia Source Type: news
Military Study Shows Prevention Of Novel A/H1N1 Virus Infection Is Vaccine-Type And Age-DependentEmail this article to a colleague.
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Immunization with either live attenuated influenza vaccine (LAIV, also known as FluMist®), or trivalent inactivated influenza vaccine (TIV), appears to offer a protection (~ 45%) against the novel A/H1N1 virus, the cause of the present influenza pandemic. However, the benefit was largely attributed to the youngest age group. The finding emerges from an evaluation of medical encounters and seasonal influenza immunization of U.S. military service members. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 20, 2009 Category: Allergy & Immunology Tags: Swine Flu Source Type: news
Immunologist At Children's Hospital Receives Daland Prize For Patient-Oriented ResearchEmail this article to a colleague.
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A pediatric immunologist at The Children's Hospital of Philadelphia has received a prestigious annual award from the American Philosophical Society, an organization founded in 1743 by Benjamin Franklin. Jordan S. Orange, M.D., Ph.D., received the Society's Judson Daland Prize on Nov. 13 for his contributions to research and treatment of inherited immune deficiency diseases. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 20, 2009 Category: Allergy & Immunology Tags: Pediatrics / Children's Health Source Type: news
Inovio Biomedical Universal DNA Vaccine For Chikungunya Virus Demonstrates Protective Antibody Responses In Monkey ModelEmail this article to a colleague.
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Inovio Biomedical Corporation (NYSE Amex: INO), a leader in DNA vaccine design, development and delivery, announced that the company's SynCon™ Chikungunya virus DNA vaccine induced protective neutralizing antibody responses in a preclinical non-human primate model. Dr. David B. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 20, 2009 Category: Allergy & Immunology Tags: Infectious Diseases / Bacteria / Viruses Source Type: news
FDA Advisory Committee Finds Data Support The Safety And Effectiveness Of Prevnar 13™ Vaccine For The Prevention Of Invasive Pneumococcal DiseasEmail this article to a colleague.
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Pfizer Inc (NYSE:PFE) announced today that the U.S. Food and Drug Administration's (FDA) Vaccines and Related Biological Products Advisory Committee voted 10 to 1 that the data presented support the safety and effectiveness of its 13-valent pneumococcal conjugate candidate vaccine, Prevnar 13™ (Pneumococcal 13-valent Conjugate Vaccine [Diphtheria CRM197 Protein]), for the prevention of invasive pneumococcal disease in infants and young children. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 20, 2009 Category: Allergy & Immunology Tags: Immune System / Vaccines Source Type: news
Extension of the swine flu vaccination programme to children aged over 6 months and under 5yearsEmail this article to a colleague.
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Source: Department of Health (DH)
Area: News
The Department of Health (DoH) has announced that the swine flu vaccination programme will be extended to children aged over 6 months and under 5 years. This age group is more likely than other groups to be hospitalised if they become ill with swine flu and young children also have high rates of admission to critical care. The DoH is working with the BMA and NHS organisations to agree the details of how the vaccine will be delivered once GPs complete the vaccination of priority groups.
Population estimates for this age group are as follow:
. 3,214,650...
Source: NeLM - Immunology and vaccination - November 20, 2009 Category: Allergy & Immunology Source Type: organizations
Matrix metalloproteinases, IL-8 and glutathione in the prognosis of workers exposed to chlorineEmail this article to a colleague.
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Conclusion: Although no accelerated loss in FEV1 was documented in these workers exposed to chlorine, subjects with a greater fall in FEV1 were more likely to report cough and have higher levels of total glutathione at Vb. (Source: Allergy)
Source: Allergy - November 20, 2009 Category: Allergy & Immunology Authors: K. Maghni, J.-L. Malo, J. L'Archevêque, L. Castellanos, D. Gautrin Source Type: journals
Anaphylaxis to patent blue V: a case series and proposed diagnostic protocolEmail this article to a colleague.
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Patent blue V is widely used in the identification of sentinel lymph nodes in patients with breast cancer and other malignancies. Individual case reports of allergy to patent blue V have been described in the medical literature since the 1960s. However, there is little data on clinical features and little experience of which allergy tests are appropriate or useful. We gathered all cases of patent blue V allergy that had been seen and diagnosed in the Department of Allergy, Addenbrooke's Hospital over a 3-year period. We collected clinical details of each case including skin test results. For comparison we recruited 12 heal...
Source: Allergy - November 20, 2009 Category: Allergy & Immunology Authors: R. A. Haque, A. Wagner, J. A. Whisken, S. M. Nasser, P. W. Ewan Source Type: journals
Egg white specific IgE levels in serum as clinical reactivity predictors in the course of egg allergy follow-upEmail this article to a colleague.
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Montesinos E, Martorell A, Félix R, Cerdá JC. Egg white specific IgE levels in serum as clinical reactivity predictors in the course of egg allergy follow-up.Pediatr Allergy Immunol 2009.© 2009 John Wiley & Sons A/S It is thought that the natural evolution of egg allergy has a good tolerance prognosis. However, there are few follow-up studies that determine the exact probability of tolerance. The aim of this study was to determine the likelihood that children younger than 2,5 years of age with allergy to egg would eventually have tolerance to it and to analyze if monitoring egg white[ndash]specific IgE level over time c...
Source: Pediatric Allergy and Immunology - November 20, 2009 Category: Allergy & Immunology Authors: Elena Montesinos, Antonio Martorell, Rubén Félix, Juan Carlos Cerdá Source Type: journals
Linkage Biosciences Unveils LinkSeqTM -- A Revolutionary New Tool For Immunogenetic TestingEmail this article to a colleague.
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Linkage Biosciences, Inc., a privately held molecular diagnostics company, recently unveiled LinkSeq™ -- a new one-step method for Human Leukocyte Antigen (HLA) testing -- at the annual meeting of the American Society of Histocompatibility and Immunogenetics (ASHI) in San Francisco. Much faster than other HLA testing methods currently available, LinkSeq™ is a proprietary sequence-specific priming (SSP) chemistry that can be analyzed utilizing real-time PCR platforms. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 19, 2009 Category: Allergy & Immunology Tags: Immune System / Vaccines Source Type: news
Also In Global Health News: Sleeping Sickness; Aid For Philippines; U.S., China In Africa; Polio Eradication In Afghanistan; Ethiopia FamineEmail this article to a colleague.
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Lancet Infectious Diseases Examines Hold-Ups In Implementation Of Sleeping Sickness Therapy (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 19, 2009 Category: Allergy & Immunology Tags: Tropical Diseases Source Type: news
Women At Risk From Vitamin A DeficiencyEmail this article to a colleague.
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Almost half of UK women could be suffering from a lack of vitamin A due to a previously undiscovered genetic variation, scientists at Newcastle University have found. The team, led by Dr Georg Lietz, has shown that almost 50 per cent of women have a genetic variation which reduces their ability to produce sufficient amounts of vitamin A from beta-carotene. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 19, 2009 Category: Allergy & Immunology Tags: Women's Health / Gynecology Source Type: news
An Overactive Immune Response Linked To Viral Infections Among ElderlyEmail this article to a colleague.
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Researchers at Yale School of Medicine have found that exaggerated responses of the immune system explain why the elderly succumb to viral infections more readily than younger people. Published in the November 19 Cell Host & Microbe, the study bucks the general belief that declining immune responses are to blame for susceptibility to viral infections. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 19, 2009 Category: Allergy & Immunology Tags: Seniors / Aging Source Type: news
GAVI Alliance Drives Down Pentavalent Vaccine Costs, Data ShowsEmail this article to a colleague.
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The "co-ordinated buying policy" of the GAVI Alliance has driven down "[t]he price of a vaccine that helps babies fight off killer diseases," according to data released by the group, Reuters reports. In 2010, the price of pentavalent vaccine, which protects against Hib (Haemophilus influenzae type b), diphtheria, whooping cough, tetanus and hepatitis B, will fall "below $3.0 - a drop of almost $0. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 19, 2009 Category: Allergy & Immunology Tags: Immune System / Vaccines Source Type: news
Have Egg Allergy? You May Still Be Candidate For Flu Vaccines, Says AllergistEmail this article to a colleague.
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As flu season got underway this fall, Dr. Catherine Monteleone, an allergist, noticed that her office started to receive an unusually high number of calls from people with egg allergy. They previously had avoided flu vaccines because of their sensitivity to eggs. This year, with all the attention being paid to the novel H1N1 influenza, those patients want to be protected against flu, and they contacted her to find out if they are candidates for inoculation. (Source: Allergy News From Medical News Today)
Source: Allergy News From Medical News Today - November 19, 2009 Category: Allergy & Immunology Tags: Swine Flu Source Type: news
Researchers Discover Antibody Receptor Identity, Propose Renaming Immune-System GeneEmail this article to a colleague.
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Researchers at the University of Alabama at Birmingham (UAB) have uncovered the genetic identity of a cellular receptor for the immune system's first-response antibody, a discovery that sheds new light on infection control and immune disorders. The discovery is such a crucial part of immunology that UAB researchers, in conjunction with Japanese researchers, are asking that the gene linked to this antibody receptor be renamed to better describe its role in early immune responses. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 19, 2009 Category: Allergy & Immunology Tags: Immune System / Vaccines Source Type: news
Projects Designed To Advance Understanding Of Molecular NetworksEmail this article to a colleague.
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NanoString Technologies, Inc., a privately held life sciences company marketing a molecular barcoding detection system, has announced that it is collaborating with the Broad Institute of MIT and Harvard to investigate molecular networks involved in immune response and other important biological processes. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 19, 2009 Category: Allergy & Immunology Tags: Immune System / Vaccines Source Type: news
Cells That Control Inflammation In Chronic DiseaseEmail this article to a colleague.
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A new type of immune cell that can be out of control in certain chronic inflammatory diseases, worsening the symptoms of conditions like psoriasis and asthma, is described for the first time this week in the Journal of Clinical Investigation. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 19, 2009 Category: Allergy & Immunology Tags: Immune System / Vaccines Source Type: news
Immune Cells On The MoveEmail this article to a colleague.
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Scientists from the Max Planck Institute (MPI) of Biochemistry in Martinsried near Munich, Germany, have now deciphered the mechanism that illustrates how these mobile cells move on diverse surfaces. "Similar to a car, these cells have an engine, a clutch and wheels which provide the necessary friction," explains Michael Sixt, a research group leader at the MPI of Biochemistry. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 19, 2009 Category: Allergy & Immunology Tags: Biology / Biochemistry Source Type: news
NHS Choices assessment of press reports about poor swine flu vaccine uptakeEmail this article to a colleague.
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Source: NHS Choices
Area: News
NHS Choices has produced an assessment of press reports that pregnant women and other vulnerable people are refusing to have the swine flu vaccine.
These news reports are based on two articles in Pulse, one on overall uptake based on a "snapshot" survey of GPs and the other, on uptake in pregnant women. Pulse surveyed 107 GPs, asking them whether they felt they would achieve the Government target in their practice of vaccinating at least half of their patients who are under 65 and in high-risk groups this winter, and the estimated vaccine uptake in their practice. The survey found...
Source: NeLM - Immunology and vaccination - November 19, 2009 Category: Allergy & Immunology Source Type: organizations
hnRNP-K is a nuclear target of TCR-activated ERK and required for T-cell late activationEmail this article to a colleague.
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Sustained extracellular signal-regulated kinase (ERK)-signaling plays a critical role in T-cell-mediated IL-2 production. Although many downstream targets are known for ERK, details remain unknown about which molecules play functional roles in IL-2 production. Here, we addressed this question using proteomic analysis of nuclear proteins from TCR-activated T cells and identified hnRNP-K as one of the ERK targets essential for IL-2 production. hnRNP-K was previously shown by others to be a direct substrate of ERK and form complexes with multiple signaling proteins as well as DNA and RNA. Our data showed a clear ERK-dependent...
Source: International Immunology - November 18, 2009 Category: Allergy & Immunology Authors: Chang, J.-W., Koike, T., Iwashima, M. Tags: ORIGINAL RESEARCH PAPERS Source Type: journals
Induction of TNF-alpha-converting enzyme-ectodomain shedding by pathogenic autoantibodiesEmail this article to a colleague.
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The release of the soluble form of tumor necrosis factor (TNF)-alpha from the plasma membrane occurs through the activation of the secretase tumor necrosis factor-alpha-converting enzyme (TACE). The current study was designed to examine whether the anti-Ro/SSA autoantibodies (Abs) are capable to regulate TACE expression in non-neoplastic human salivary gland epithelial cells (SGEC) cultures. We investigated the effect of anti-Ro/SSA Abs on the localization and abundance of cell-surface TACE and on TACE pro-domain-shedding and activation. In addition, the potential physiological consequences of TNF-alpha blockage by the bio...
Source: International Immunology - November 18, 2009 Category: Allergy & Immunology Authors: Sisto, M., Lisi, S., Lofrumento, D. D., Frassanito, M. A., Cucci, L., D'Amore, S., Mitolo, V., D'Amore, M. Tags: ORIGINAL RESEARCH PAPERS Source Type: journals
Regulatory and pro-inflammatory phenotypes of myelin basic protein-autoreactive T cells in multiple sclerosisEmail this article to a colleague.
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MBP-specific autoreactive T cells are considered pro-inflammatory T cells and thought to play an important role in the pathogenesis of multiple sclerosis (MS). Here, we report that MBP83–99-specific T cells generated from MS patients (n = 7) were comprised of pro-inflammatory and regulatory subsets of distinct phenotypes. The pro-inflammatory phenotype was characterized by high production of IFN-, IL-6, IL-21 and IL-17 and low expression of FOXP3, whereas the regulatory subset expressed high levels of FOXP3 and exhibited potent regulatory functions. The regulatory subset of MBP-specific T cells appeared to expand fro...
Source: International Immunology - November 18, 2009 Category: Allergy & Immunology Authors: Hong, J., Li, H., Chen, M., Zang, Y. C. Q., Skinner, S. M., Killian, J. M., Zhang, J. Z. Tags: Featured article of the month Source Type: journals
Expression of fully assembled TCR-CD3 complex on double positive thymocytes: synergistic role for the PRS and ER retention motifs in the intra-cytoplasmic tail of CD3{varepsilon}Email this article to a colleague.
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TCR expression on double-positive (DP) thymocytes is a prerequisite for thymic selection that results in the generation of mature CD4+ and CD8+ single-positive T cells. TCR is expressed at very low level on preselection DP thymocytes and is dramatically up-regulated on positively selected thymocytes. However, mechanism governing TCR expression on developing thymocytes is not understood. In the present report, we demonstrate that the intra-cytoplasmic (IC) domain of CD3 plays a critical role in regulating TCR expression on DP thymocytes. We provide genetic and biochemical evidence to show that the CD3 IC domain mutations re...
Source: International Immunology - November 18, 2009 Category: Allergy & Immunology Authors: Brodeur, J.-F., Li, S., Damlaj, O., Dave, V. P. Tags: ORIGINAL RESEARCH PAPERS Source Type: journals
The study of allergy by Japanese researchers: a historical perspectiveEmail this article to a colleague.
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This article is aimed at introducing such individual work and how these areas have contributed to our understanding of the mechanisms of allergic reactions. (Source: International Immunology)
Source: International Immunology - November 18, 2009 Category: Allergy & Immunology Authors: Takai, T., Karasuyama, H. Tags: REVIEWS Source Type: journals
IL-5- and eosinophil-mediated inflammation: from discovery to therapyEmail this article to a colleague.
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IL-5 was originally defined as a T-cell-derived cytokine that triggers activated B cells for terminal differentiation into antibody-secreting plasma cells, at least in mice. Concurrently, IL-5 was recognized as the major maturation and differentiation factor for eosinophils in mice and humans. Over-expression of IL-5 significantly increases eosinophil numbers and antibody levels in vivo. Conversely, mice lacking a functional gene for IL-5 or the IL-5 receptor alpha chain (IL-5R) display a number of developmental and functional impairments in B-cell and eosinophil lineages. In addition to the Janus kinase–signal trans...
Source: International Immunology - November 18, 2009 Category: Allergy & Immunology Authors: Kouro, T., Takatsu, K. Tags: REVIEWS Source Type: journals
In this issueEmail this article to a colleague.
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(Source: International Immunology)
Source: International Immunology - November 18, 2009 Category: Allergy & Immunology Tags: IN THIS ISSUE Source Type: journals
Cell phenotyping in saliva of individuals under psychological stress.Email this article to a colleague.
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Total leukocytes, NK cells, B and T lymphocytes present in the saliva of medical students with or without stress were quantified by flow cytometry in 10,000 events. The symptoms of psychological stress were monitored with Lipp's Inventory of Stress Symptoms for Adults (ISSL). No significant differences were observed in the number of cells phenotyped in students with and those without psychological stress. However, a negative correlation was observed between the number of NK cells and T lymphocytes in students with stress (r=-0.8173; p=0.0058), suggesting that innate immunity is predominant in the adaptation phase.
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Source: Cellular Immunology - November 18, 2009 Category: Allergy & Immunology Authors: Dos-Santos MC, Matos-Gomes N, Makimoto FH, Katsurayama M, Santana LL, Becker MA, Paredes-Garcia E, Bertho AL Tags: Cell Immunol Source Type: journals
Lipoic acid attenuates high fat diet-induced chronic oxidative stress and immunosuppression in mice jejunum: a microarray analysis.Email this article to a colleague.
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A high fat diet (HFD) has long been linked to immune dysfunction, including diminished numbers or reactivity of lymphocytes, increased susceptibility to infection, inhibited lymphocytes function during antigen-specific responses and developed oxidative stress. Whereas the molecular mechanistic events associated with immune deficiency remain to be fully determined. Using the DNA microarray system, we analyzed the gene expression patterns of lymphocyte related signal transduction proteins in jejunum of C57BL/6 mice in order to gain insight on the possible molecular mechanism by which HFD induced oxidative stress effects ...
Source: Cellular Immunology - November 18, 2009 Category: Allergy & Immunology Authors: Cui J, Le G, Yang R, Shi Y Tags: Cell Immunol Source Type: journals
T lineage differentiation from induced pluripotent stem cells.Email this article to a colleague.
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In this study, we co-cultured iPS cells on OP9 cells expressing the Notch ligand Delta-like 1 (DL1), the iPS cells differentiated into T lymphocytes. In addition, in vitro stimulation of iPS cell-derived T lymphocytes resulted in secretion of IL-2 and IFN-gamma. Moreover, adoptive transfer of iPS cell-derived T lymphocytes into Rag-deficient mice reconstituted their T cell pools. These results indicate that iPS cells are able to follow the normal program of T cell differentiation.
PMID: 19811778 [PubMed - indexed for MEDLINE] (Source: Cellular Immunology)
Source: Cellular Immunology - November 18, 2009 Category: Allergy & Immunology Authors: Lei F, Haque R, Weiler L, Vrana KE, Song J Tags: Cell Immunol Source Type: journals
Fast generation of dendritic cells.Email this article to a colleague.
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Dendritic cells (DC) are potent antigen presenting cells capable of inducing immune responses. DC are widely used as vaccine adjuvant in experimental clinical settings. DC-based vaccines are normally generated using a standard 8day DC protocol (SDDC). In attempts to shorten the vaccine production we have developed fast DC protocol by comparing two different fast DC protocols with SDDC. DC were evaluated by FACS analysis, and the optimal profile was considered: CD14(low), CD80(high), CD83(high), CD86(high), CCR7(high), HLA class I and II(high). FACS profiles were used as the selection criteria together with yield and mo...
Source: Cellular Immunology - November 18, 2009 Category: Allergy & Immunology Authors: Kvistborg P, Boegh M, Pedersen AW, Claesson MH, Zocca MB Tags: Cell Immunol Source Type: journals
Qiliqiangxin regulates the balance between tumor necrosis factor-alpha and interleukin-10 and improves cardiac function in rats with myocardial infarction.Email this article to a colleague.
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The study investigated the effects of traditional Chinese drug Qiliqiangxin on cardiac function and the expression of pro/anti-inflammatory cytokines TNF-alpha/IL-10 in rats with myocardial infarction (MI). Rats with MI were randomly divided into drug-treated group (MI-Q) and control group (MI-C) compared with sham-operated group (S). Rats in the MI-Q group were treated with crude drug of oral Qiliqiangxin 24h after operation at the dosage of 4g/kg/day for 4weeks, while in MI-C group and S group were treated with normal saline at the same time. Echocardiography and hemodynamic parameters, histopathologic changes and th...
Source: Cellular Immunology - November 18, 2009 Category: Allergy & Immunology Authors: Xiao H, Song Y, Li Y, Liao YH, Chen J Tags: Cell Immunol Source Type: journals
KHN Column: Is Fear Of Flu Shifting The Goal Posts?Email this article to a colleague.
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In this column for Kaiser Health News, Shannon Brownlee and Jeanne Lenzer write about the swine flu. "If any public health message has alarmed Americans in recent weeks, it is the repeated claim in the media that healthy young people are dying of 2009 H1N1, or swine flu. ... (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 18, 2009 Category: Allergy & Immunology Tags: Swine Flu Source Type: news
GAVI's Impact On Vaccine Market Is Bringing Down PricesEmail this article to a colleague.
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Following the increasing impact of the GAVI Alliance on the vaccine market, the price of one of the major combination vaccines, the pentavalent, is falling considerably, enabling GAVI's partners to vaccinate millions of more children in the developing world. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 18, 2009 Category: Allergy & Immunology Tags: Immune System / Vaccines Source Type: news
