Allergy & Immunology 
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This page shows you the most recent publications within this specialty of the MedWorm directory.
111080 records returned
Protumor activity of interleukin‐22 in HPAFII human pancreatic cancer cells
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In this report, we showed that IL‐22 stimulated production of vascular endothelial growth factor (VEGF) and the anti‐apoptotic factor Bcl‐XL in IL‐22R‐positive HPAFII human pancreatic cancer cells. Additionally, IL‐22 augmented HPAFII cell production of immunosuppressive cytokines. We further showed that IL‐22 activation of HPAFII cells diminished T cell production of IFN‐γ through the action of IL‐10. Strikingly, we showed for the first time that IL‐22 can fully protect cancer cells from NK cell‐mediated cytotoxicity by stimulating tumor production of IL‐10 and TGF‐β1. Our data supports the ide...
Source: Clinical and Experimental Immunology - February 5, 2012 Category: Allergy & Immunology Authors: L. M. CurdS. E. FavorsR. K. Gregg Source Type: research
Breastfeeding Linked to Better Lung Function (CME/CE)Email this article to a colleague.
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(MedPage Today) -- Children who were breastfed for at least four months had significantly better lung function at age 12 than did children who were not breastfed, data from a large cohort study showed. (Source: MedPage Today Allergy)
Source: MedPage Today Allergy - February 4, 2012 Category: Allergy & Immunology Source Type: news
Immune SentinelsEmail this article to a colleague.
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A classic paradigm in immunology holds that the immune response occurs in two waves: Rapidly responding cells of the innate immune system help to contain the invading pathogen and alert … [Read more] (Source: This Week in Science)
Source: This Week in Science - February 3, 2012 Category: Science Authors: Stewart Wills (mailto:swills at aaas.org) Source Type: research
National Peanut Butter Day No Picnic for Kids with Peanut AllergiesEmail this article to a colleague.
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National Peanut Butter Day is No Picnic for Kids with Peanut Allergies, But Educating Our Kids About Food Allergies Can Be - With over six million children in the US now facing peanut and other food allergies, food allergy education in schools is a must. Author Sue Ganz-Schmitt strives to help with the release of her children's book The Princess and the Peanut. (Source: Disabled World)
Source: Disabled World - February 3, 2012 Category: Disability Tags: Food Allergy - Intolerance Source Type: news
The role of the HLA-G gene and molecule on the clinical expression of rheumatologic diseasesEmail this article to a colleague.
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O antígeno leucocitário humano G (HLA-G) é uma molécula não clássica de complexo principal de histocompatibilidade (MHC) de classe I, caracterizada por baixo polimorfismo em sua região codificadora, um padrão de distribuição tecidual limitado em condições fisiológicas e expressão por meio de isoformas solúveis e acopladas à superfície de membranas por meio de splicing alternativo. O HLA-G é bastante conhecido por estar envolvido na indução e na manutenção da tolerância entre o sistema imunológico materno e o feto semialogênico ao nível da interface fetoplacentária. Além disso, diversos estudos a...
Source: Revista Brasileira de Reumatologia - February 3, 2012 Category: Rheumatology Source Type: research
cetirizine, Zyrtec, Zyrtec Allergy, Zyrtec HivesEmail this article to a colleague.
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Title: cetirizine, Zyrtec, Zyrtec Allergy, Zyrtec HivesCategory: MedicationsCreated: 12/31/1997Last Editorial Review: 2/3/2012 (Source: MedicineNet Allergies General)
Source: MedicineNet Allergies General - February 3, 2012 Category: Allergy & Immunology Source Type: news
hydrocortisone oral, Hydrocortone, CortefEmail this article to a colleague.
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Title: hydrocortisone oral, Hydrocortone, CortefCategory: MedicationsCreated: 12/31/1997Last Editorial Review: 2/3/2012 (Source: MedicineNet Allergies General)
Source: MedicineNet Allergies General - February 3, 2012 Category: Allergy & Immunology Source Type: news
clarithromycin, Biaxin, Biaxin XLEmail this article to a colleague.
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Title: clarithromycin, Biaxin, Biaxin XLCategory: MedicationsCreated: 12/31/1997Last Editorial Review: 2/3/2012 (Source: MedicineNet Allergies General)
Source: MedicineNet Allergies General - February 3, 2012 Category: Allergy & Immunology Source Type: news
Altered frequency and phenotype of CD4+FOXP3+ T cells and its association with autoantibody production in HIV‐infected paediatric patientsEmail this article to a colleague.
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SummaryThe association between immune dysfunction and the development of autoimmune pathology in patients with HIV/AIDS is not clear. The frequency and phenotype of regulatory T cells, as well as the presence of autoantibodies were evaluated in a paediatric cohort of HIV‐infected patients without clinical evidence of autoimmune disease. Lower absolute counts but higher percentages of total CD4+FOXP3+ T cells were recorded in children with severe immunosuppression than in those without evidence of immunosuppression. The frequencies of classical CD4+CD25+FOXP3+regulatory T cells were not altered, whereas CD4+FOXP3+CD25–T...
Source: Clinical and Experimental Immunology - February 3, 2012 Category: Allergy & Immunology Authors: Rafael ArgüelloJeanette BalbaryskiGraciela BarboniMarcela CandiEduardo GaddiSusana Laucella Source Type: research
Bronchial And Alveolar Nitric Oxide In Exercise‐Induced Bronchoconstriction In Asthmatic ChildrenEmail this article to a colleague.
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Conclusions and Clinical Relevance:Our results suggest that inflammation is present in the central and peripheral airways and that it is associated with the severity of EIB. Clinicaltrials.govNCT00952835© 2012 Blackwell Publishing Ltd (Source: Clinical and Experimental Allergy)
Source: Clinical and Experimental Allergy - February 3, 2012 Category: Allergy & Immunology Authors: Iolanda ChinellatoMichele PiazzaDiego PeroniMarco SandriFerdinando ChiorazzoAttilio L BonerGiorgio Piacentini Tags: Original Article‐Asthma and Rhinitis Source Type: research
Pink EyeEmail this article to a colleague.
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Pink eye can be caused by a virus, fungus, bacteria, allergy or by something irritating the eye. Sometimes, pink eye is a sign of a more serious infection like chlamydia or gonorrhea. (Source: About.com Eating Disorders)
Source: About.com Eating Disorders - February 3, 2012 Category: Eating Disorders and Weight Management Authors: weightloss.guide at about.com Tags: health Source Type: news
Coughing and other respiratory symptoms improve within weeks of smoking cessationEmail this article to a colleague.
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(Mary Ann Liebert, Inc./Genetic Engineering News) A new study shows that 18- to 24-year olds who stop smoking for at least two weeks report substantially fewer respiratory symptoms, especially coughing. The study appears in the peer-reviewed journal Pediatric Allergy, Immunology, and Pulmonology. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - February 3, 2012 Category: Global & Universal Source Type: news
Lower levels of sunlight link to allergy and eczemaEmail this article to a colleague.
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(The Peninsula College of Medicine and Dentistry) Increased exposure to sunlight may reduce the risk of both food allergies and eczema in children, according to a new scientific study published this week. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 3, 2012 Category: Global & Universal Source Type: news
On the nature of sarcoidosis.Email this article to a colleague.
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Abstract
More than 140years since its recognition as a clinical entity, sarcoidosis remains enigmatic. Its classification as a disease vs. a syndrome is uncertain. Its etiology remains undefined. The "immune paradox" (delayed type hypersensitivity anergy in a setting of exuberant systemic granulomatous response) resists explanation. Its relationship to the Kveim test is poorly understood. Its prognostic determinants and treatment indications are among the unsolved or disputed problems. Immunological investigations generated the thesis that the characterizing systemic granuloma arise as a fallback reaction to ineffi...
Source: European Journal of Internal Medicine - February 2, 2012 Category: Internal Medicine Authors: Reich JM Tags: Eur J Intern Med Source Type: research
S&M USA Enterprise Issues an Alert on Undeclared Sulfites in Zhang Zhou Brand TremellaEmail this article to a colleague.
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S&M USA ENTERPRISE is recalling ZHANG ZHOU BRAND TREMELLA because it may contain undeclared sulfites. People who have severe sensitivity to sulfites run the risk of serious or life-threatening allergic reactions if they consume this product. (Source: Food and Drug Administration)
Source: Food and Drug Administration - February 2, 2012 Category: Food Science Source Type: news
Etonogestrel: Allergic reaction leading to implant expulsion: case reportEmail this article to a colleague.
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(Source: Reactions)
Source: Reactions - February 2, 2012 Category: Drugs & Pharmacology Tags: Short communication Source Type: research
£4m boost for MRC-Asthma UK CentreEmail this article to a colleague.
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The Medical Research Council (MRC) and GlaxoSmithKline (GSK) have co-funded a groundbreaking programme of asthma research at the MRC-Asthma UK Centre in Allergic Mechanisms of Asthma. (Source: Medical Research Council Research News)
Source: Medical Research Council Research News - February 2, 2012 Category: Research Source Type: news
An Empirical Investigation on System and Statement Level Parallelism Strategies for Accelerating Scatter Search Using Handel-C and Impulse-CEmail this article to a colleague.
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Scatter Search is an effective and established population-based metaheuristic that has been used to solve a variety of hard optimization problems. However, the time required to find high-quality solutions can become prohibitive as problem sizes grow. In this paper, we present a hardware implementation of Scatter Search on a field-programmable gate array (FPGA). Our objective is to improve the run time of Scatter Search by exploiting the potentially massive performance benefits that are available through the native parallelism in hardware. When implementing Scatter Search we employ two different high-level languages (HLLs):...
Source: Clinical and Developmental Immunology - February 2, 2012 Category: Allergy & Immunology Source Type: research
New Bandwidth Selection for Kernel Quantile EstimatorsEmail this article to a colleague.
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We propose a cross-validation method suitable for smoothing of kernel quantile estimators. In particular, our proposed method selects the bandwidth parameter, which is known to play a crucial role in kernel smoothing, based on unbiased estimation of a mean integrated squared error curve of which the minimising value determines an optimal bandwidth. This method is shown to lead to asymptotically optimal bandwidth choice and we also provide some general theory on the performance of optimal, data-based methods of bandwidth choice. The numerical performances of the proposed methods are compared in simulations, and the new band...
Source: Clinical and Developmental Immunology - February 2, 2012 Category: Allergy & Immunology Source Type: research
Acid-Base Disorders in Patients with Chronic Obstructive Pulmonary Disease: A Pathophysiological ReviewEmail this article to a colleague.
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The authors describe the pathophysiological mechanisms leading to development of acidosis in patients with chronic obstructive pulmonary disease and its deleterious effects on outcome and mortality rate. Renal compensatory adjustments consequent to acidosis are also described in detail with emphasis on differences between acute and chronic respiratory acidosis. Mixed acid-base disturbances due to comorbidity and side effects of some drugs in these patients are also examined, and practical considerations for a correct diagnosis are provided. (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - February 2, 2012 Category: Allergy & Immunology Source Type: research
Optimised In2S3 Thin Films Deposited by Spray PyrolysisEmail this article to a colleague.
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Indium sulphide has been extensively investigated as a component for different kind of photovoltaic devices (organic-inorganic hybrid devices, all inorganic, dye sensitized cells). In this paper, we have optimised the growth conditions of indium sulphide thin films by means of a low cost, versatile deposition technique, like spray pyrolysis. The quality of the deposited films has been characterised by micro-Raman, vis-UV spectroscopy, and atomic force microscopy. Substrate deposition temperature and different postdeposition annealing conditions have been investigated in order to obtain information about the quality of the ...
Source: Clinical and Developmental Immunology - February 2, 2012 Category: Allergy & Immunology Source Type: research
Molecular Mechanism of Macrophage Activation by Red Ginseng Acidic Polysaccharide from Korean Red GinsengEmail this article to a colleague.
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In this study, we aimed to explore the mechanism of molecular activation of RGAP in macrophages. RGAP treatment strongly induced NO production in RAW264.7 cells without altering morphological changes, although the activity was not strong compared to LPS-induced dendritic-like morphology in RAW264.7 cells. RGAP-induced NO production was accompanied with enhanced mRNA levels of iNOS and increases in nuclear transcription factors such as NF-κB, AP-1, STAT-1, ATF-2, and CREB. According to pharmacological evaluation with specific enzyme inhibitors, Western blot analysis of intracellular signaling proteins and inhibitory p...
Source: Clinical and Developmental Immunology - February 2, 2012 Category: Allergy & Immunology Source Type: research
Dyspnea Caused by Atlantoaxial Subluxation in a Patient with Rheumatoid ArthritisEmail this article to a colleague.
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We report a patient with rheumatoid arthritis whose chief complaint was dyspnea on arrival to the emergency department (ED). After further investigation, spinal cord compression caused by atlantoaxial subluxation was diagnosed. This is an uncommon but important case that ED physicians should be aware of. (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - February 2, 2012 Category: Allergy & Immunology Source Type: research
Ruthenium Sensitizers and Their Applications in Dye-Sensitized Solar CellsEmail this article to a colleague.
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Dye-sensitized solar cells (DSSCs) have attracted considerable attention in recent years due to the possibility of low-cost conversion of photovoltaic energy. The DSSCs-based ruthenium complexes as sensitizers show high efficiency and excellent stability, implying potential practical applications. This review focuses on recent advances in design and preparation of efficient ruthenium sensitizers and their applications in DSSCs, including thiocyanate ruthenium sensitizers and thiocyanate-free ruthenium sensitizers. (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - February 2, 2012 Category: Allergy & Immunology Source Type: research
W-Stability of Multistable Nonlinear Discrete-Time SystemsEmail this article to a colleague.
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Motivated by the importance and application of discrete dynamical systems, this paper presents a new Lyapunov characterization which is an extension of conventional Lyapunov characterization for multistable discrete-time nonlinear systems. Based on a new type stability notion of W-stability introduced by D. Efimov, the estimates of solution and the Lyapunov stability theorem and converse theorem are proposed for multi-stable discrete-time nonlinear systems. (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - February 2, 2012 Category: Allergy & Immunology Source Type: research
Effect of Etching Time on Optical and Thermal Properties of p-Type Porous Silicon Prepared by Electrical Anodisation MethodEmail this article to a colleague.
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The porous silicon (PSi) layers were formed on p-type silicon (Si) wafer. The six samples were anodised electrically with 30 mA/cm2 fixed current density for different etching times. The structural, optical, and thermal properties of porous silicon on silicon substrates were investigated by photoluminescence (PL), photoacoustic spectroscopy (PAS), and UV-Vis-NIR spectrophotometer. The thickness and porosity of the layers were measured using the gravimetric method. The band gap of the samples was measured through the photoluminescence (PL) peak and absorption spectra, then they were compared. It shows that band gap v...
Source: Clinical and Developmental Immunology - February 2, 2012 Category: Allergy & Immunology Source Type: research
A Unified Method of Analysis for Queues with Markovian ArrivalsEmail this article to a colleague.
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We deal with finite-buffer queueing systems fed by a Markovian point
process. This class includes the queues of type M/G/1/N, MX/G/1/N, PH/G/1/N,
MMPP/G/1/N, MAP/G/1/N, and BMAP/G/1/N and is commonly used in the performance evaluation of network traffic buffering processes. Typically, such queueing
systems are studied in the stationary regime using matrix-analytic methods connected with M/G/1-type Markov processes. Herein, another method for finding
transient and stationary characteristics of these queues is presented. The approach
is based on finding a closed-form formula for the Laplace transform of the time-dependent pe...
Source: Clinical and Developmental Immunology - February 2, 2012 Category: Allergy & Immunology Source Type: research
Occult Follicular Thyroid Carcinoma Presenting as a Frontal Bone Metastasis: A Case ReportEmail this article to a colleague.
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This is a rare case of metastatic follicular carcinoma of thyroid in a patient with no history of thyroid problem. A frontal bone mass was examined microscopically and showed the pattern of metastatic follicular carcinoma. Thyroid ultrasonography then revealed a nodule in left lobe. Total thyroidectomy was done for the patient and microscopic examination confirmed the diagnosis. (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - February 2, 2012 Category: Allergy & Immunology Source Type: research
Epidemiology, Clinical Manifestations, and Long-Term Outcomes of a Major Outbreak of Chikungunya in a Hamlet in Sri Lanka, in 2007: A Longitudinal Cohort StudyEmail this article to a colleague.
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Chikungunya outbreaks occurred in the central province, Sri Lanka in 2006. This community-based study reports the epidemiology and the natural history of the infection from an affected village. Of the 199 families and 1001 individuals in the village, 159 (80%) and 513 (51%) were affected, respectively, comprising 237 (46%) males with peak incidence at 40–50 years. The acute illness caused polyarthritis in 233 (46%), and of them 230 (98%) progressed to chronic arthritic disability (CAD). Of the CAD patients, 102 (44%) had recovered in 141 days (range 30–210 days) from the disability stat...
Source: Clinical and Developmental Immunology - February 2, 2012 Category: Allergy & Immunology Source Type: research
Lipid-Laden Alveolar Macrophages and pH Monitoring in Gastroesophageal Reflux-Related Respiratory SymptomsEmail this article to a colleague.
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This study was conducted to prove a correlation between the detection of alimentary pulmonary fat phagocytosis and an increasing amount of proximal gastroesophageal reflux. It was assumed that proximal gastroesophageal reflux better correlates with aspiration than distal GER. Patients from 6 months to 16 years with unexplained recurrent wheezy bronchitis and bronchial hyperreactivity, or recurrent pneumonia with chronic cough underwent 24-hour double-channel pH monitoring and bronchoscopy with bronchoalveolar lavage (BAL). Aspiration of gastric content was determined by counting lipid laden alveolar macrophages from BAL sp...
Source: Clinical and Developmental Immunology - February 2, 2012 Category: Allergy & Immunology Source Type: research
Single-Crystal MgO Hollow Nanospheres Formed in RF Impulse Discharge PlasmasEmail this article to a colleague.
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Spherical MgO nanoparticles with a hollow inside, that is, MgO hollow nanospheres, were created in Ar/O2 plasma produced by radio frequency (RF) impulse discharge using a Mg rod electrode. The hollow nanospheres were found on the SiO2 plates placed near the powered Mg electrode. The electron refraction pattern showed that each nanosphere was made of a single crystal of MgO. Since the shape was spherical, these nanoparticles seemed to be created during the levitation in the plasma without touching any walls. The formation mechanism with a quasiliquid cooling model was also discussed. (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - February 2, 2012 Category: Allergy & Immunology Source Type: research
Zuonin B Inhibits Lipopolysaccharide-Induced Inflammation via Downregulation of the ERK1/2 and JNK Pathways in RAW264.7 MacrophagesEmail this article to a colleague.
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In conclusion, the anti-inflammatory effects of Zuonin B are attributable to the suppression of proinflammatory cytokines and mediators via blockage of NF-κB and AP-1 activation. Based on these findings, we propose that Zuonin B is potentially an effective functional chemical candidate for the prevention of inflammatory diseases. (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - February 2, 2012 Category: Allergy & Immunology Source Type: research
On Stochastic Finite-Time Control of Discrete-Time Fuzzy Systems with Packet DropoutEmail this article to a colleague.
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This paper is concerned with the stochastic finite-time stability and stochastic finite-time boundedness problems for one family of fuzzy discrete-time systems over networks with packet dropout, parametric uncertainties, and time-varying norm-bounded disturbance. Firstly, we present the dynamic model description studied, in which the discrete-time fuzzy T-S systems with packet loss can be described by one class of fuzzy Markovian jump systems. Then, the concepts of stochastic finite-time stability and stochastic finite-time boundedness and problem formulation are given. Based on Lyapunov function approach, sufficient condi...
Source: Clinical and Developmental Immunology - February 2, 2012 Category: Allergy & Immunology Source Type: research
Statistical Analysis of Ratio of Random Variables and Its Application in Performance Analysis of Multihop Wireless TransmissionsEmail this article to a colleague.
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The distributions of random variables are of interest in many areas of science. In this paper, the probability density function (PDF) and cumulative distribution function (CDF) of ratio of products of two random variables and random variable are derived. Random variables are described with Rayleigh, Nakagami-m, Weibull, and α-μ distributions. An application of obtained results in performance analysis of multihop wireless communication systems in different transmission environments described in detail. The proposed mathematical analysis is also complemented by various graphically presented numerical results....
Source: Clinical and Developmental Immunology - February 2, 2012 Category: Allergy & Immunology Source Type: research
Ethnopharmacokinetic- and Activity-Guided Isolation of a New Antidepressive Compound from Fructus Aurantii Found in the Traditional Chinese Medicine Chaihu-Shugan-San: A New Approach and Its ApplicationEmail this article to a colleague.
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Conclusion. MH, a compound whose antidepressive effect is similar to FA and CSS, was isolated for the first time from FA via targeting its corresponding unknown chromatographic peak, and its antidepressive effect was compared with FA or CSS. These findings highlight the potential for drug R&D and pharmacological research of ∼100,000 TCMs. (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - February 2, 2012 Category: Allergy & Immunology Source Type: research
Unusual Presentation of Rare Case of Papillary Adenofibroma of Cervix in a Young WomanEmail this article to a colleague.
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We report the case of a large polypoidal mass per vagina occupying the whole pelvis in a young woman. Preoperative biopsy showed benign epithelial and mullerian mesenchymal components suggestive of mullerian adenofibroma. Total hysterectomy with bilateral salpingectomy was done. The diagnosis of papillary adenofibroma of cervix was made. The total surgery assured complete excision and permitted adequate sampling to exclude malignancy. (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - February 2, 2012 Category: Allergy & Immunology Source Type: research
Multifunctional CD4+T cells in patients with American cutaneous leishmaniasisEmail this article to a colleague.
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SummaryLeishmaniasis is a group of important parasitic diseases affecting millions worldwide. To understand more clearly the quality of T helper type 1 (Th1) response stimulated after Leishmania infection, we applied a multiparametric flow cytometry protocol to evaluate multifunctional T cells induced by crude antigen extracts obtained from promastigotes of Leishmania braziliensis (LbAg) and Leishmania amazonensis (LaAg) in peripheral blood mononuclear cells from healed cutaneous leishmaniasis patients. Although no significant difference was detected in the percentage of total interferon (IFN)‐γ‐producing CD4+T cells ...
Source: Clinical and Experimental Immunology - February 2, 2012 Category: Allergy & Immunology Authors: A. B. B. MacedoJ. C. Sánchez‐ArcilaA. O. SchubachS. C. F. MendonçaA. Marins‐Dos‐SantosM. de Fatima MadeiraT. GaginiM. I. F. PimentelP. M. De Luca Source Type: research
Impaired phagocytosis among patients infected by the human immunodeficiency virus: implication for a role of highly active anti‐retroviral therapyEmail this article to a colleague.
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SummaryIn patients with human immunodeficiency virus (HIV) infection, neutrophil and monocyte functions, including phagocytosis, are impaired. The purpose of this study was to investigate changes of phagocytic function and respiratory burst occurring over the course of patients infected by the HIV‐1 virus. Treatment‐naive patients (group B), patients receiving highly active anti‐retroviral treatment (HAART) (group C) and patients in which HAART has failed (group D) were studied and compared with healthy volunteers (group A). Phagocytosis and oxidative burst were evaluated using commercially available kits. Results cl...
Source: Clinical and Experimental Immunology - February 2, 2012 Category: Allergy & Immunology Authors: C. MichailidisG. GiannopoulosV. VigklisK. ArmenisA. TsakrisP. Gargalianos Source Type: research
Enhanced levels of CCL19 in patients with advanced acquired immune deficiency syndrome (AIDS)Email this article to a colleague.
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SummaryBased on the ability to recruit lymphocytes and dendritic cells to lymphoid tissue and to promote inflammation, we hypothesized a role for dysregulated CCL19 and CCL21 levels in human immunodeficiency virus (HIV)‐infected patients with advanced immunodeficiency, and in particular in those with accompanying Mycobacterium avium complex (MAC) infection. The hypothesis was explored by studies in HIV‐infected patients with and without MAC infection, as well as in vitro, examining the ability of proteins from MAC to promote CCL19 and CCL21 responses in peripheral blood mononuclear cells (PBMC) during highly active ant...
Source: Clinical and Experimental Immunology - February 2, 2012 Category: Allergy & Immunology Authors: J. K. DamåsO. ØktedalenT. UelandL. LandrøJ. BarstadF. MüllerS. S. FrølandT. H. FloP. Aukrust Source Type: research
Complete deficiency of the sixth complement component (C6Q0), susceptibility to Neisseria meningitidis infections and analysis of the frequencies of C6Q0 gene defects in South AfricansEmail this article to a colleague.
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SummaryComplete complement component 6 deficiency (C6Q0) is a co‐dominant genetic disease presenting as increased susceptibility to invasive Neisseria meningitidis infections. Affected individuals have two affected alleles which can be homozygous or compound heterozygous for the particular gene defects they carry. This disorder has been diagnosed relatively frequently in Western Cape South Africans. Affected patients are prescribed penicillin prophylaxis. In 2004 we commenced a clinical follow‐up study of 46 patients. Of these, 43 had family age‐matched C6 sufficient controls. Participants were classified as either (...
Source: Clinical and Experimental Immunology - February 2, 2012 Category: Allergy & Immunology Authors: A. OrrenE. P. OwenH. E. HendersonL. van der MerweF. LeisegangC. StassenP. C. Potter Source Type: research
Early exposure of interferon‐γ inhibits signal transducer and activator of transcription‐6 signalling and nuclear factor κB activation in a short‐term monocyte‐derived dendritic cell culture promoting ‘FAST’ regulatory dendritic cellsEmail this article to a colleague.
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SummaryInterferon (IFN)‐γ is a cytokine with immunomodulatory properties, which has been shown previously to enhance the generation of tolerogenic dendritic cells (DC) when administered early ex vivo in 7‐day monocyte‐derived DC culture. To generate tolerogenic DC rapidly within 48 h, human monocytes were cultured for 24 h with interleukin (IL)‐4 and granulocyte–macrophage colony‐stimulating factor (GM‐CSF) in the presence (IFN‐γ‐DC) or absence of IFN‐γ (500 U/ml) (UT‐DC). DC were matured for 24 h with TNF‐α and prostaglandin E2 (PGE2). DC phenotype, signal transducer and activator of tr...
Source: Clinical and Experimental Immunology - February 2, 2012 Category: Allergy & Immunology Authors: D. Rojas‐CanalesR. KrishnanC. F. JessupP. T. Coates Source Type: research
Synthetic peptides containing ITIM‐like sequences of IREM‐1 (CD300F) differentially regulate MyD88 and TRIF‐mediated TLR signalling through activation of SHP and/or PI3KEmail this article to a colleague.
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SummaryThe immune receptor expressed on myeloid cells 1 (IREM‐1/CD300F) has been shown to inhibit various inflammatory processes in myeloid cells, such as macrophages and mast cells. IREM‐1 exerts its inhibitory effect through its intracellular immunoreceptor tyrosine‐based inhibition motifs (ITIMs). In order to generate immunomodulatory molecules that can regulate the inflammatory activation of macrophages, decapeptides representing each of the five ITIM‐like sequences in the cytoplasmic tail of IREM‐1 were synthesized in conjugation with human immunodeficiency virus‐transactivator of transcription (HIV‐TAT4...
Source: Clinical and Experimental Immunology - February 2, 2012 Category: Allergy & Immunology Authors: S‐M. LeeK. SukW‐H. Lee Source Type: research
Thin‐layer chromatography immunostaining in detecting anti‐phospholipid antibodies in seronegative anti‐phospholipid syndromeEmail this article to a colleague.
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SummaryIn clinical practice it is possible to find patients with clinical signs suggestive of anti‐phospholipid syndrome (APS) who are persistently negative for the routinely used anti‐phospholipid antibodies (aPL). Therefore, the term proposed for these cases was seronegative APS (SN‐APS). We investigated the clinical usefulness of thin‐layer chromatography (TLC) immunostaining in detecting serum aPL in patients presenting clinical features of SN‐APS. Sera from 36 patients with SN‐APS, 19 patients with APS, 18 patients with systemic lupus erythematosus (SLE), 20 anti‐hepatitis C virus (HCV)‐positive subjec...
Source: Clinical and Experimental Immunology - February 2, 2012 Category: Allergy & Immunology Authors: F. ContiC. AlessandriM. SoriceA. CapozziA. LongoT. GarofaloR. MisasiD. BompaneG. R. V. HughesM. A. KhamashtaG. Valesini Source Type: research
Enterocytes: active cells in tolerance to food and microbial antigens in the gutEmail this article to a colleague.
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SummaryEnterocytes used to be studied particularly in terms of digestion protagonists. However, as the immune functions of the intestinal tract were better understood, it became clear that enterocytes are not mere bystanders concerning the induction of immune tolerance to dietary peptides and gut microbiota. In fact, enterocytes are involved actively in shaping the intestinal immune environment, designed for maintaining a non‐belligerent state. This tolerant milieu of the gut immune system is achieved by keeping a balance between suppression and stimulation of the inflammatory responses. Our review presents the current s...
Source: Clinical and Experimental Immunology - February 2, 2012 Category: Allergy & Immunology Authors: N. MironV. Cristea Source Type: research
Immunology in clinic review series; focus on autoinflammatory diseases: update on monogenic autoinflammatory diseases: the role of interleukin (IL)‐1 and an emerging role for cytokines beyond IL‐1Email this article to a colleague.
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OTHER THEMES PUBLISHED IN THIS IMMUNOLOGY IN THE CLINIC REVIEW SERIESAllergy, Host Responses, Cancer, Type 1 diabetes and viruses, Metabolic diseases.SummaryThe disease‐based discovery of the molecular basis for autoinflammatory diseases has led not only to a rapidly growing number of clinically and genetically identifiable disorders, but has unmantled key inflammatory pathways such as the potent role of the alarm cytokine interleukin (IL)‐1 in human disease. Following its initial failures in the treatment of sepsis and the moderate success in the treatment of rheumatoid arthritis, IL‐1 blocking therapies had a renai...
Source: Clinical and Experimental Immunology - February 2, 2012 Category: Allergy & Immunology Authors: R. Goldbach‐Mansky Source Type: research
Immunology in clinic review series; focus on autoinflammatory diseases: role of inflammasomes in autoinflammatory syndromesEmail this article to a colleague.
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OTHER THEMES PUBLISHED IN THIS IMMUNOLOGY IN THE CLINIC REVIEW SERIESAllergy, Host Responses, Cancer, Type 1 diabetes and viruses, Metabolic diseases.SummaryAutoinflammatory syndromes are disorders characterized by the hyperactivation of the innate immune system in the absence of microbial infection or autoantibody production. Some autoinflammatory syndromes are associated with recurrent episodes of fever and systemic inflammation that are caused by dysregulated activation of inflammasomes, molecular platforms responsible for the activation of caspase‐1 and the production of interleukin (IL)‐1β. In this review we will...
Source: Clinical and Experimental Immunology - February 2, 2012 Category: Allergy & Immunology Authors: V. U. OzkuredeL. Franchi Source Type: research
Immunology in clinic review series; focus on autoinflammatory diseases: inflammasomes: mechanisms of activationEmail this article to a colleague.
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OTHER THEMES PUBLISHED IN THIS IMMUNOLOGY IN THE CLINIC REVIEW SERIESAllergy, Host Responses, Cancer, Type 1 diabetes and viruses, Metabolic diseases.SummaryInitiation of a successful immune response requires a working set of sensors that detect any noxious agent within the cellular microenvironment and molecular platforms that process this signal to trigger an appropriate effector response. Pattern recognition receptors can engage different signalling cascades that lead to proinflammatory gene expression. At the same time, transcription‐independent events such as activation of proteases and/or phagocytosis are also init...
Source: Clinical and Experimental Immunology - February 2, 2012 Category: Allergy & Immunology Authors: A. K. MankanA. KubarenkoV. Hornung Source Type: research
Murine lupus strains differentially model unique facets of human lupus serologyEmail this article to a colleague.
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SummarySystemic lupus erythematosus is a polygenic autoimmune disease characterized by the production of antinuclear autoantibodies that lead to subsequent end organ damage. Previous array‐based studies in patients with SLE have shown that high IgG anti‐nuclear autoantibody reactivity was associated with severe renal lupus whereas IgM polyreactivity was associated with less severe disease. To ascertain how different murine lupus strains recapitulate these different autoantibody profiles seen in patients, serum from NZB/NZW F1, MRL/lpr, NZM2410 and BXSB strains were compared using a comprehensive array–based screen. T...
Source: Clinical and Experimental Immunology - February 2, 2012 Category: Allergy & Immunology Authors: Li LiSatyavani NukalaYong DuJie HanKui LiuJack HutchesonSimanta PathakQuanzhen LiChandra Mohan Source Type: research
Detailed Analysis of Peripheral Blood Natural Killer Cells in Women with Repeated IVF FailureEmail this article to a colleague.
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ConclusionsPeripheral blood NK cell activity is significantly higher in women with RIF than in fertile controls. Future trials of immune therapy in women undergoing IVF should target those with high NK activity. (Source: American Journal of Reproductive Immunology)
Source: American Journal of Reproductive Immunology - February 2, 2012 Category: Allergy & Immunology Authors: Gavin SacksYang YangElizabeth GowenSusan SmithLouise FayMichael Chapman Tags: Original Article Source Type: research
A long‐term follow‐up of allergic diseases in IcelandEmail this article to a colleague.
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Discussion: The prevalence of allergic diseases is high in Iceland among children and young individuals. Asthma and atopic eczema are very common in childhood, but decreases with age while the prevalence of rhinoconjunctivitis increases markedly. The very high and increasing prevalence of rhinoconjunctivitis among 15‐ to 21‐year‐old individuals is noteworthy. (Source: Pediatric Allergy and Immunology)
Source: Pediatric Allergy and Immunology - February 2, 2012 Category: Allergy & Immunology Authors: Anna Freyja FinnbogadóttirBjörn ÁrdalHerbert EiríkssonBirgir HrafnkelssonHelgi ValdimarssonBjörn Rúnar LúðvíkssonÁsgeir Haraldsson Tags: ORIGINAL ARTICLE Source Type: research
