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HIV Vaccine Strategy Expands Immune ResponsesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Two teams of researchers including Los Alamos National Laboratory theoretical biologists Bette Korber, Will Fischer, Sydeaka Watson, and James Szinger have announced an HIV vaccination strategy that has been shown to expand the breadth and depth of immune responses in rhesus monkeys. Rhesus monkeys provide the best animal model currently available for testing HIV vaccines... (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - March 17, 2010 Category: Allergy & Immunology Tags: HIV / AIDS Source Type: news

It's Time To Reassess Where We Stand With An HIV Vaccine As Numbers Infected Rise In UN StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
According to a recent United Nations study, HIV infection rates among high-risk groups such as gays, drug users and sex workers are on the rise around the world. U.N. AIDS agency chief Michel Sidibe is saying the increase may be due to worsening discrimination against these groups in certain countries. In the U.S... (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - March 17, 2010 Category: Allergy & Immunology Tags: HIV / AIDS Source Type: news

Black Children At Lower Risk Of Shingles After Chickenpox Vaccine; Genetic Explanation Is Most Likely, Researchers ThinkEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Black children are less likely than white or Asian children to develop shingles (herpes zoster) after receiving the varicella vaccine to prevent chickenpox, reports a study in the March issue of The Pediatric Infectious Disease Journal... (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - March 17, 2010 Category: Allergy & Immunology Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

Revolade(R) (Eltrombopag) Receives European Marketing Authorisation For The Treatment Of Chronic Immune Thrombocytopenic Purpura (ITP)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
GlaxoSmithKline (GSK) announced that the European Medicines Agency (EMA) has granted marketing authorisation for Revolade® (eltrombopag), a once-daily oral treatment for adults with chronic immune thrombocytopenic purpura (ITP)... (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - March 17, 2010 Category: Allergy & Immunology Tags: Blood / Hematology Source Type: news

Identification Of Gene That May Play A Key Role In Atherosclerosis And Other DiseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To understand the role of inflammation in cardiovascular and other diseases, it is essential to identify and characterize genes that induce an inflammatory response in the body -- and the genes that regulate them... (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - March 17, 2010 Category: Allergy & Immunology Tags: Heart Disease Source Type: news

An imbalance in mucosal cytokine profile causes transient intestinal inflammation following an animal's first exposure to faecal bacteria and antigensEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study examined the effects of faecal bacteria and antigen exposure on the intestinal mucosal and systemic immune system in healthy axenic mice. Axenic wild-type mice were inoculated orally with a crude faecal slurry solution derived from conventionally raised mice and were analysed prior to and then at days 3, 7, 14 and 28 post-treatment. Ingestion of faecal slurry resulted in a transient, early onset of proinflammatory interferon (IFN)-[gamma], tumour necrosis factor (TNF)-[alpha] and interleukin (IL)-17 response that was maximal at day 3. In contrast, the transient release of the anti-inflammatory cytokines IL-10 an...
Source: Clinical and Experimental Immunology - March 17, 2010 Category: Allergy & Immunology Authors: B. C. Sydora, S. M. MacFarlane, M. Lupicki, A. L. Dmytrash, L. A. Dieleman, R. N. Fedorak Source Type: journals

Maternal Death Following Cardiopulmonary Collapse After Delivery: Amniotic Fluid Embolism or Septic Shock Due to Intrauterine Infection?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion We propose that subclinical intraamniotic infection may be a cause of postpartum cardiovascular collapse and DIC and resemble AFE. Thus, some patients with the clinical diagnosis of AFE may have infection/systemic inflammation as a mechanism of disease. These observations have implications for the understanding of the mechanisms of disease of patients who develop cardiovascular collapse and DIC, frequently attributed to AFE. It may be possible to identify a subset of patients who have biochemical and immunological evidence of systemic inflammation at the time of admission, and before a catastrophic event occurs....
Source: American Journal of Reproductive Immunology - March 17, 2010 Category: Allergy & Immunology Authors: Roberto Romero, Nicholas Kadar, Edi Vaisbuch, Sonia S. Hassan Source Type: journals

Women with multiple implantation failures and recurrent pregnancy losses have increased peripheral blood T cell activationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Women with MIFs or RPLs have increased T cell activation in peripheral blood lymphocytes, and T cell suppressor activation seems to be associated with decreased Th1 immunity. Further studies on T cell activation may elucidate molecular mechanisms controlling Th1 effectors. (Source: American Journal of Reproductive Immunology)
Source: American Journal of Reproductive Immunology - March 17, 2010 Category: Allergy & Immunology Authors: Kwang Moon Yang, Evangelos Ntrivalas, Hye Jin Cho, Na Young Kim, Kenneth Beaman, Alice Gilman-Sachs, Joanne Kwak-Kim Source Type: journals

Governing the Invasive Trophoblast: Current Aspects on Intra- and Extracellular RegulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Citation Fitzgerald JS, Germeyer A, Huppertz B, Jeschke U, Knöfler M, Moser G, Scholz C, Sonderegger S, Toth B, Markert UR. Governing the invasive trophoblast: current aspects on intra- and extracellular regulation. Am J Reprod Immunol 2010 This review summarizes several aspects especially of regulating factors governing trophoblast invasion. Those include the composition of the extracellular matrix containing a variety of matrix metalloproeinases and their inhibitors, but also intracellular signals. Furthermore, a newly described trophoblast subtype, the endoglandular trophoblast, is presented. Its presence may provide a...
Source: American Journal of Reproductive Immunology - March 17, 2010 Category: Allergy & Immunology Authors: Justine S. Fitzgerald, Ariane Germeyer, Berthold Huppertz, Udo Jeschke, Martin Knöfler, Gerit Moser, Christoph Scholz, Stefan Sonderegger, Bettina Toth, Udo R. Markert Source Type: journals

Elevated NK Cell Cytotoxicity, CD158a Expression in NK Cells and Activated T Lymphocytes in Peripheral Blood of Women with IVF FailuresEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Citation Chernyshov VP, Sudoma IO, Dons'koi BV, Kostyuchyk AA, Masliy YV. Elevated NK cell cytotoxicity, CD158a expression in NK cells and activated T lymphocytes in peripheral blood of women with IVF failures. Am J Reprod Immunol 2010Problem The aim of this study was to evaluate the role of elevated natural killer cytotoxicity (NKc) in women with multiple implantation failures (IF) in vitro fertilization[ndash]embryo transfer (IVF[ndash]ET) cycles.Methods of study Seventy-nine antiphospholipid antibodies-negative women with IF including 33 women with elevated NKc were selected for investigation. K-562 cell line was used t...
Source: American Journal of Reproductive Immunology - March 17, 2010 Category: Allergy & Immunology Authors: Viktor P. Chernyshov, Iryna O. Sudoma, Boris V. Dons'koi, Anton A. Kostyuchyk, Yulia V. Masliy Source Type: journals

First Successful Pregnancy after Addition of Enoxaparin to Sildenafil and Etanercept Immunotherapy in Woman with Fifteen Failed IVF Cycles – Case ReportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Combination therapy that includes a heparin may allow successful IVF outcome and this issue merits further study. (Source: American Journal of Reproductive Immunology)
Source: American Journal of Reproductive Immunology - March 17, 2010 Category: Allergy & Immunology Authors: Małgorzata Jerzak, Tomasz Niemiec, Anna Nowakowska, Monika Klochowicz, Andrzej Górski, Włodzimierz Baranowski Source Type: journals

Evaluation of thyroglobulin expression in murine reproductive organs during pregnancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion It is likely that antithyroglobulin antibodies have no direct detrimental effect on such organs in patients with thyroid autoimmunity suffering from recurrent abortion. (Source: American Journal of Reproductive Immunology)
Source: American Journal of Reproductive Immunology - March 17, 2010 Category: Allergy & Immunology Authors: Ali Moravej, Mahmood Jeddi-Tehrani, Ali R. Salek-Moghaddam, Pouneh Dokouhaki, Roya Ghods, Hodjatallah Rabbani, Golnaz E. Kazemi-Sefat, Mehdi Shahbazi, Amir H. Zarnani Source Type: journals

Interrupting the Cough Reflex in AsthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The impact of coughing for patients with asthma may be more important than currently appreciated, and has been rated more troublesome than wheeze, chest tightness, or disturbance of sleep. Current Opinion in Allergy and Clinical Immunology (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - March 16, 2010 Category: Allergy & Immunology Tags: Allergy & Clinical Immunology Source Type: info

GAVI Calls Meeting With Existing, Potential DonorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The GAVI Alliance has "asked existing and potential donors to a meeting in The Hague on March 25 and 26 to challenge them to 'make a strong impact' on childhood death rates," Reuters reports... (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - March 16, 2010 Category: Allergy & Immunology Tags: Pediatrics / Children's Health Source Type: news

Keeping Up With The Neighbors Speeds Vaccine UseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers at the Johns Hopkins Bloomberg School of Public Health conducted an analysis of worldwide use of Haemophilus influenza Type b vaccine (Hib) to determine what factors influenced a nation's adoption of the vaccine... (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - March 16, 2010 Category: Allergy & Immunology Tags: Immune System / Vaccines Source Type: news

Stem Cells Might One Day Treat Severe AsthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: Stem Cells Might One Day Treat Severe AsthmaCategory: Health NewsCreated: 3/15/2010 4:10:00 PMLast Editorial Review: 3/16/2010 (Source: MedicineNet Allergies General)
Source: MedicineNet Allergies General - March 16, 2010 Category: Allergy & Immunology Source Type: consumer

Obesity Impairs Body's "Memory" Of How To Fight FluEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Obesity may limit the body's ability to develop immunity to influenza viruses, particularly secondary infections, by inhibiting the immune system's ability to "remember" how it fought off previous similar bouts of illness, according to new research from the University of North Carolina at Chapel Hill... (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - March 16, 2010 Category: Allergy & Immunology Tags: Flu / Cold / SARS Source Type: news

Activation of signal transducer and activator of transcription-1 (STAT-1) and differential expression of interferon-γ and anti-inflammatory proteins in pelvic ileal pouches for ulcerative colitis and familial adenomatous polyposisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pouchitis after total rectocolectomy is the most common complication of ulcerative colitis (UC). The immunological mechanisms involved in the genesis of pouchitis are unclear. Therefore, we evaluated the inflammatory activity in normal ileal pouch mucosa by determining signal transducers and activators of transcription (STAT-1) activation and cytokine expression in patients operated for UC and familial adenomatous polyposis (FAP). Eighteen asymptomatic patients, who underwent total rectocolectomy and J pouch, were evaluated: nine with UC and nine with FAP. The activation of STAT-1 and cytokine expression were determined by...
Source: Clinical and Experimental Immunology - March 16, 2010 Category: Allergy & Immunology Authors: R. F. Leal, M. L. S. Ayrizono, M. Milanski, A. Coope, J. J. Fagundes, L. A. Velloso, C. S. R. Coy Source Type: journals

Tolerance induction after specific immunotherapy with pollen allergoids adjuvanted by monophosphoryl lipid A in childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Specific immunotherapy (SIT) is a well-established and clinically effective treatment for allergic diseases. A pollen allergoid formulated with the T helper type 1 (Th1)-inducing adjuvant monophosphoryl lipid A (MPL) facilitates short-term SIT. Little is known about mechanisms of tolerance induction in this setting. In a prospective study, 34 patients allergic to grass pollen (25 male, nine female, median age 10·2 years) received a total of 44 SIT courses (20 in the first, 24 in the second) with MPL-adjuvanted pollen allergoids. Immunogenicity was measured by levels of specific immunoglobulin G (IgGgrass) and IgG4grass by...
Source: Clinical and Experimental Immunology - March 16, 2010 Category: Allergy & Immunology Authors: M. Rosewich, J. Schulze, O. Eickmeier, T. Telles, M. A. Rose, R. Schubert, S. Zielen Source Type: journals

Various effects of different probiotic strains in allergic disorders: an update from laboratory and clinical dataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Epidemiological data show that allergic children have a different intestinal flora from healthy children with higher levels of Clostridia and lower levels of Bifidobacteria. Nonetheless, Bifidobacteria and Lactobacilli are found more commonly in the composition of the intestinal flora of non-allergic children. Probiotics are ingested live microbes that can modify intestinal microbial populations in a way that benefits the host and they are represented mainly by Lactobacilli. Enhanced presence of probiotic bacteria in the intestinal microbiota is found to correlate with protection against atopy. There is also very promising...
Source: Clinical and Experimental Immunology - March 16, 2010 Category: Allergy & Immunology Authors: Ö. Özdemir Source Type: journals

A role for human endogenous retrovirus-K (HML-2) in rheumatoid arthritis: investigating mechanisms of pathogenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Human endogenous retroviruses (HERVs) are remnants of ancient retroviral infections within the human genome. These molecular fossils draw parallels with present-day exogenous retroviruses and have been linked previously with immunopathology within rheumatoid arthritis (RA). Mechanisms of pathogenesis for HERV-K in RA such as molecular mimicry were investigated. To clarify a role for HERVs in RA, potential autoantigens implicated in autoimmunity were scanned for sequence identity with retroviral epitopes. Short retroviral peptides modelling shared epitopes were synthesized, to survey anti-serum of RA patients and disease co...
Source: Clinical and Experimental Immunology - March 16, 2010 Category: Allergy & Immunology Authors: G. Freimanis, P. Hooley, H. Davari Ejtehadi, H. A. Ali, A. Veitch, P. B. Rylance, A. Alawi, J. Axford, A. Nevill, P. G. Murray, P. N. Nelson Source Type: journals

Ketamine reduces inducible superoxide generation in human neutrophils in vitro by modulating the p38 mitogen-activated protein kinase (MAPK)-mediated pathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Many cellular stresses and inflammatory stimuli can activate p38 mitogen-activated protein kinase (MAPK), a serine/threonine kinase in the MAPK family. The different stimuli act via different receptors or signalling pathways to induce phosphorylation of the cytosolic protein p47phox, one subunit of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. Formyl[ndash]methionyl[ndash]leucyl[ndash]phenylalanine (fMLP) has been shown to induce the p38 MAPK phosphorylation during the respiratory burst in human neutrophils. Here, we show that treatment with S(+)-ketamine or R(-)-ketamine at different concentrations (50,...
Source: Clinical and Experimental Immunology - March 16, 2010 Category: Allergy & Immunology Authors: Huang-Wei Lu, Guan-Nan He, Hong Ma, Jun-Ke Wang Source Type: journals

Mitigation of septic shock in mice and rhesus monkeys by human chorionic gonadotrophin-related oligopeptidesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The marked improvement of several immune-mediated inflammatory diseases during pregnancy has drawn attention to pregnancy hormones as potential therapeutics for such disorders. Low molecular weight fractions derived from the pregnancy hormone human chorionic gonadotrophin (hCG) have remarkable potent immunosuppressive effects in mouse models of diabetes and septic shock. Based on these data we have designed a set of oligopeptides related to the primary structure of hCG and tested these in models of septic shock in mice and rhesus monkeys. We demonstrate that mice exposed to lipopolysaccharide (LPS) and treated subsequently...
Source: Clinical and Experimental Immunology - March 16, 2010 Category: Allergy & Immunology Authors: N. A. Khan, M. P. M. Vierboom, C. van Holten [ndash] Neelen, E. Breedveld, E. Zuiderwijk-Sick, A. Khan, I. Kondova, G. Braskamp, H. F. J. Savelkoul, W. A. Dik, B. A. 't Hart, R. Benner Source Type: journals

Cyclophilin–CD147 interactions: a new target for anti-inflammatory therapeuticsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CD147 is a widely expressed plasma membrane protein that has been implicated in a variety of physiological and pathological activities. It is best known for its ability to function as extracellular matrix metalloproteinase inducer (hence the other name for this protein, EMMPRIN), but has also been shown to regulate lymphocyte responsiveness, monocarboxylate transporter expression and spermatogenesis. These functions reflect multiple interacting partners of CD147. Among these CD147-interacting proteins cyclophilins represent a particularly interesting class, both in terms of structural considerations and potential medical i...
Source: Clinical and Experimental Immunology - March 16, 2010 Category: Allergy & Immunology Authors: V. Yurchenko, S. Constant, E. Eisenmesser, M. Bukrinsky Source Type: journals

Altered expression of signalling lymphocyte activation molecule (SLAM) family receptors CS1 (CD319) and 2B4 (CD244) in patients with systemic lupus erythematosusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we have investigated the expression and alternative splicing of CS1 and 2B4 in immune cells from SLE patients. The surface expression of CS1 and 2B4 on total peripheral blood mononuclear cells (PBMCs), T, B, natural killer (NK) cells and monocytes in 45 patients with SLE and 30 healthy individuals was analysed by flow cytometry. CS1-positive B cell population was increased significantly in SLE patients. Because CS1 is a self-ligand and homophilic interaction of CS1 induces B cell proliferation and autocrine cytokine secretion, this could account for autoreactive B cell proliferation in SLE. The proportion of...
Source: Clinical and Experimental Immunology - March 16, 2010 Category: Allergy & Immunology Authors: J. R. Kim, S. O. Mathew, R. K. Patel, R. M. Pertusi, P. A. Mathew Source Type: journals

Coupled regulation of interleukin-12 receptor beta-1 of CD8+ central memory and CCR7-negative memory T cells in an early alloimmunity in liver transplant recipientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, this work demonstrated that the IL-12R[beta]1+ cells of TCM and CNS are regulated in a tightly coupled manner and that expression levels of IL-12R[beta]1+ TCM play a crucial role in controlling allo- and infectious immunity. (Source: Clinical and Experimental Immunology)
Source: Clinical and Experimental Immunology - March 16, 2010 Category: Allergy & Immunology Authors: H. Egawa, K. Ozawa, Y. Takada, S. Teramukai, A. Mori, K. Ogawa, T. Kaido, Y. Fujimoto, Y. Kawaguchi, E. Hatano, H. Sato, M. Ono, K. Takai, K. Tanaka, S. Uemoto Source Type: journals

Toluene diisocyanate (TDI) regulates haem oxygenase-1/ferritin expression: implications for toluene diisocyanate-induced asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study of toluene diisocyanate (TDI)-OA, we found identical findings with increased transferrin and decreased ferritin levels in the serum of patients with TDI-OA. To elucidate whether diisocyanate suppresses FTL synthesis directly, we tested the effect of TDI on the FTL synthesis in A549 cells, a human airway epithelial cell line. We found that haem oxygenase-1 as well as FTL was suppressed by treatment with TDI in dose- and time-dependent manners. We also found that the synthesis of other anti-oxidant proteins such as thioredoxin-1, glutathione peroxidase, peroxiredoxin 1 and catalase were suppressed by TDI. Furth...
Source: Clinical and Experimental Immunology - March 16, 2010 Category: Allergy & Immunology Authors: S.-H. Kim, G.-S. Choi, Y.-M. Ye, I. Jou, H.-S. Park, S. M. Park Source Type: journals

Rhinosinusitis and ComorbiditiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract A variety of systemic conditions impact the incidence, severity, prognosis, and treatment approach in patients with chronic rhinosinusitis (CRS). The controversy surrounding the impact of allergic rhinitis on CRS continues, but it is reasonable to consider and treat allergic sources of inflammation in any patient with CRS. CRS is more severe in patients with aspirin sensitivity but improves—at least temporarily—to the same degree as in non-aspirin-sensitive patients, given appropriate therapy. Polypoid rhinosinusitis in cystic fibrosis patients is characterized by compromised mucociliary clearan...
Source: Current Allergy and Asthma Reports - March 15, 2010 Category: Allergy & Immunology Tags: Current Allergy and Asthma Reports Source Type: journals

GAVI Alliance Reaches Agreement With Drugmakers On Reduced-Price Pneumococcal VaccinesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Several drugmakers have reached an agreement "to supply up to 200 million doses a year of cut-price pneumococcal vaccines to developing nations," according to GAVI Alliance, Reuters reports. A formal announcement of the deal is expected "in the next couple of weeks," GAVI's Deputy Chief Executive Officer Helen Evans told the news service Thursday... (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - March 15, 2010 Category: Allergy & Immunology Tags: Pharma Industry / Biotech Industry Source Type: news

Lack of neo-sensitization to Pen a 1 in patients treated with mite sublingual immunotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Patients did not show neo-sensitization to tropomyosin, a component of the extract (namely mite group 10) administered. An assessment of a patient's possible pre-existing sensitisation to tropomyosin by skin test and/or specific IgE prior to start mite extract immunotherapy is recommended. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - March 15, 2010 Category: Allergy & Immunology Authors: Renato RossiGiorgio MonasteroloCristoforo IncorvaiaPhilippe MoingeonFranco FratiGiovanni PassalacquaLucilla RossiGiorgio Canonica Source Type: journals

Uptake of apoptotic DC converts immature DC into tolerogenic DC that induce differentiation of Foxp3+ TregEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we showed that immature viable DC have the ability to uptake apoptotic DC as well as necrotic DC without it being recognized as an inflammatory event by immature viable DC. However, the specific uptake of apoptotic DC converted immature viable DC into tolerogenic DC, which were resistant to LPS-induced maturation. These tolerogenic DC secreted increased levels of TGF-[beta]1, which induced differentiation of naïve T cells into Foxp3+ Treg. Furthermore, induction of Treg differentiation only occurred upon uptake of apoptotic DC and not apoptotic splenocytes by viable DC, indicating that it is specifically th...
Source: European Journal of Immunology - March 15, 2010 Category: Allergy & Immunology Authors: Rahul Kushwah, Jing Wu, Jordan R. Oliver, George Jiang, Jinyi Zhang, Katherine A. Siminovitch, Jim Hu Source Type: journals

Identification of a novel allele HLA-A*240220 by polymerase chain reaction sequence-based typing in a Chinese individualEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
HLA-A*240220 has one nucleotide change from HLA-A*24020101 at position 201 in exon 2 from G to C. (Source: Tissue Antigens)
Source: Tissue Antigens - March 15, 2010 Category: Allergy & Immunology Authors: F.-M. Zhu, W. Wang, W. Zhang, H.-J. Lv, L.-X. Yan Source Type: journals

BioSante Announces Positive Leukemia Vaccine ResultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
BioSante Pharmaceuticals, Inc. (NASDAQ: BPAX) announced positive results of a human clinical study that show that its GVAX Leukemia vaccine may be able to reduce or eliminate the last remaining cancer cells in some chronic myeloid leukemia (CML) patients taking the drug Gleevec (imatinib mesylate)... (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - March 14, 2010 Category: Allergy & Immunology Tags: Lymphoma / Leukemia / Myeloma Source Type: news

Baxter Presents Clinical Efficacy Results From Phase III Study Of Seasonal Flu VaccineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Baxter International Inc. (NYSE:BAX), in conjunction with DynPort Vaccine Company LLC (DVC), a CSC Company (NYSE:CSC), presented Phase III study data measuring the clinical efficacy for PREFLUCEL, a trivalent seasonal influenza candidate vaccine. PREFLUCEL is made using Baxter's Vero cell culture platform and does not contain an adjuvant or preservatives... (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - March 14, 2010 Category: Allergy & Immunology Tags: Flu / Cold / SARS Source Type: news

The role of activation-induced cell death in the higher onset of spontaneous apoptosis of NK cell subsets in patients with metastatic epithelial cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To address the question whether the higher onset of apoptosis of circulating NK cell subsets might be activation induced in cancer patients, surface expression of NKG2D and serum (s) levels of MHC class I chain-related (MIC) proteins in relation to apoptosis marker and CD95 expression on NK cells were evaluated. Patients showed a significantly higher onset of spontaneous apoptosis of CD56dim NK cells. No difference in the CD95 expression could be detected between patients and normal controls (NCs). Patients' CD56bright NK cells demonstrated a higher expression of NKG2D compared to CD56dim NK cells. The sMICB levels sho...
Source: Cellular Immunology - March 14, 2010 Category: Allergy & Immunology Authors: Stanzer S, Janesch B, Resel M, Augustin T, Samonigg H, Bauernhofer T Tags: Cell Immunol Source Type: journals

Cyclophosphamide induces bone marrow to yield higher numbers of precursor dendritic cells in vitro capable of functional antigen presentation to T cells in vivo.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We have shown recently that cyclophosphamide (CTX) treatment induced a marked increase in the numbers of immature dendritic cells (DCs) in blood, coinciding with enhanced antigen-specific responses of the adoptively transferred CD8(+) T cells. Because this DC expansion was preceded by DC proliferation in bone marrow (BM), we tested whether BM post CTX treatment can generate higher numbers of functional DCs. BM was harvested three days after treatment of C57BL/6 mice with PBS or CTX and cultured with GM-CSF/IL-4 in vitro. Compared with control, BM from CTX-treated mice showed faster generation and yielded higher numbers...
Source: Cellular Immunology - March 14, 2010 Category: Allergy & Immunology Authors: Salem ML, El-Naggar SA, Cole DJ Tags: Cell Immunol Source Type: journals

B1 cells produce nitric oxide in response to a series of toll-like receptor ligands.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The effect of a series of toll-like receptor (TLR) ligands on the production of nitric oxide (NO) in mouse B1 cells was examined by using CD5(+) IgM(+) WEHI 231 cells. The stimulation with a series of TLR ligands, which were Pam3Csk4 for TLR1/2, poly I:C for TLR3, lipopolysaccharide (LPS) for TLR4, imiquimod for TLR7 and CpG DNA for TLR9, resulted in enhanced NO production via augmented expression of an inducible type of NO synthase (iNOS). LPS was most potent for the enhancement of NO production, followed by poly I:C and Pam3Csk4. Imiquimod and CpG DNA led to slight NO production. The LPS-induced NO production was dep...
Source: Cellular Immunology - March 14, 2010 Category: Allergy & Immunology Authors: Tumurkhuu G, Koide N, Dagvadorj J, Noman AS, Khuda II, Naiki Y, Komatsu T, Yoshida T, Yokochi T Tags: Cell Immunol Source Type: journals

A cell permeant peptide containing the cytoplasmic tail sequence of Fc receptor type IIA reduces calcium signaling and phagolysosome formation in neutrophils.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Receptors for the Fc domain of IgG mediate target recognition, signal transduction, and effector functions including antibody-dependent cytolysis, phagocytosis, and phagolysosome formation. To better understand FcR-mediated functions and to identify potential therapeutic strategies, we employed cell-penetrating ("Trojan") peptides to deliver "wild-type" (LTL) or modified (AAA) FcgammaRIIA tail sequences to the neutrophil's cytoplasm. The Trojan-LTL peptide appeared to label the endoplasmic reticulum whereas the Trojan-AAA peptide distributed throughout the cytoplasm. The Trojan-LTL peptide, but not the Trojan-AAA pepti...
Source: Cellular Immunology - March 14, 2010 Category: Allergy & Immunology Authors: Clark AJ, Petty HR Tags: Cell Immunol Source Type: journals

G-protein-coupled receptor independent, immunomodulatory properties of chemokine CXCL9.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Certain chemokines possess anti-angiogenic and antibacterial activity, in addition to their ability to recruit leukocytes. Herein, we demonstrate that CXCL9/MIG induces the expression, by a monocytic cell line and peripheral blood mononuclear cells, of a variety of chemokines including CXCL8/IL-8, CCL3/MIP-1alpha, CCL4/MIP-1beta, CCL2/MCP-1 in a pertussis toxin insensitive manner. Similarly, another cationic chemokine CCL20/MIP-3alpha, but not the non-cationic chemokines CCL2 or CCL3, stimulated monocytic cells to produce substantial amounts of CXCL8 and CCL3. Microarray experiments demonstrated that CXCL9, but not CCL...
Source: Cellular Immunology - March 14, 2010 Category: Allergy & Immunology Authors: Gong JH, Nicholls EF, Elliott MR, Brown KL, Hokamp K, Roche FM, Cheung CY, Falsafi R, Brinkman FS, Bowdish DM, Hancock RE Tags: Cell Immunol Source Type: journals

Expression and functional analyses of liver expressed antimicrobial peptide-2 (LEAP-2) variant forms in human tissues.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The antimicrobial peptide Liver Expressed Antimicrobial Peptide-2 (LEAP-2) is proposed to function as part of the vertebrate innate immune system. However, the highly conserved nature of the LEAP-2 peptide primary structure among vertebrates suggests more fundamental physiological roles. RT-PCR analyses confirmed expression of LEAP-2 mRNA variants in human gastro-intestinal (GI) epithelial tissues and THP-1 monocytes. Three cDNA products indicative of at least three different spliced transcripts were observed. Translation of the cDNA sequences supported synthesis of transcripts encoding the secreted LEAP-2 peptide and ...
Source: Cellular Immunology - March 14, 2010 Category: Allergy & Immunology Authors: Howard A, Townes C, Milona P, Nile CJ, Michailidis G, Hall J Tags: Cell Immunol Source Type: journals

Suppression of murine experimental autoimmune encephalomyelitis by interleukin-2 receptor targeted fusion toxin, DAB(389)IL-2.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Previously we have shown that DAB(389)IL-2, a recombinant fusion toxin targeting IL-2R bearing cells, suppressed disease in the rat experimental autoimmune encephalomyelitis (EAE) model of acute multiple sclerosis (MS). Our present study demonstrates that DAB(389)IL-2 can also effectively suppress acute (A)-EAE, relapsing (R)-EAE and chronic (C)-EAE in mouse demyelinating models. DAB(389)IL-2 significantly suppressed mitogenic proliferation of spleen cells while mutant fusion proteins DA(glu53)B(389)IL-2 and DAB(389)IL-2(8-10) did not. EAE was successfully suppressed when DAB(389)IL-2 was administered in various regime...
Source: Cellular Immunology - March 14, 2010 Category: Allergy & Immunology Authors: Phillips SM, Bhopale MK, Hilliard B, Zekavat SA, Ali MA, Rostami A Tags: Cell Immunol Source Type: journals

Regulatory T cells (CD4(+)CD25(bright)FoxP3(+)) expansion in systemic sclerosis correlates with disease activity and severity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Increased numbers of Treg cells are present in patients with SSc, correlating with activity and severity of the disease. This expansion of Treg cells was not accompanied, however, by heightened TGF-beta or IL-10 production. Further studies to elaborate the causes and functional significance of Treg cell expansion in SSc are needed. PMID: 20096404 [PubMed - indexed for MEDLINE] (Source: Cellular Immunology)
Source: Cellular Immunology - March 14, 2010 Category: Allergy & Immunology Authors: Slobodin G, Ahmad MS, Rosner I, Peri R, Rozenbaum M, Kessel A, Toubi E, Odeh M Tags: Cell Immunol Source Type: journals

Interleukin-18 and interferon-gamma polymorphisms in Brazilian human immunodeficiency virus-1-infected patients presenting with lipodystrophy syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cytokines play important roles in the pathogenesis of lipodystrophy syndrome (LS). Single nucleotide polymorphisms (SNPs) at positions [minus]607(C/A) and [minus]137(C/G) in the promoter region of the interleukin-18 (IL-18) gene and at position +874(T/A) of the interferon-gamma (IFN-[gamma]) gene are related to the expression of these cytokines. To examine whether IL-18 and IFN-[gamma] polymorphisms are associated with LS, these SNPs were genotyped in 88 human immunodeficiency virus (HIV)-infected patients presenting LS, 79 HIV-infected without LS, and 133 healthy controls. The [minus]607A allele, [minus]607AA genotype, an...
Source: Tissue Antigens - March 14, 2010 Category: Allergy & Immunology Authors: L. Castelar, M. M. Silva, E. C. Castelli, N. H. S. Deghaide, C. T. Mendes-Junior, A. A. Machado, E. A. Donadi, A. P. M. Fernandes Source Type: journals

Association of canine juvenile generalized demodicosis with the dog leukocyte antigen systemEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Demodectic mange is a well-known parasitic skin disease characterized by the presence of a larger than normal number of Demodex mites (Demodex canis) in the skin of dogs. Recent research has suggested that major histocompatibility complex (MHC) class II expression is higher in the skin of dogs suffering from demodicosis than in normal ones. We have investigated whether canine Dog Leukocyte Antigen (DLA) class II alleles are associated with canine juvenile generalized demodicosis (JGD). In the present study, the analysis of microsatellite markers (FH2202, FH2975 and FH2054) linked to DLA was made in Boxer, Argentinean Masti...
Source: Tissue Antigens - March 14, 2010 Category: Allergy & Immunology Authors: V. It, L. Barrientos, J. López Gappa, D. Posik, S. Díaz, C. Golijow, G. Giovambattista Source Type: journals

Identification of a novel HLA-DRB1*11 variant allele, DRB1*1189Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Here, we describe the identification of a novel human leukocyte antigen (HLA)-DRB1 allele, DRB1*1189, that was found in an Italian Caucasian individual. This sequence differs from HLA-DRB1*1134 by three nucleotide exchange at positions 286 (C[rarr]T), 296 (A[rarr]G), and 308 (C[rarr]A) in exon 2. (Source: Tissue Antigens)
Source: Tissue Antigens - March 14, 2010 Category: Allergy & Immunology Authors: M. Curcio, S. Fornaciari, M. Pistello, E. Andreoli, F. Scatena, S. Barbuti, M. L. Mariotti Source Type: journals

Lost in a tsunami of references: the Babel tower strikes againEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Tissue Antigens)
Source: Tissue Antigens - March 14, 2010 Category: Allergy & Immunology Authors: J. A. B. Chies, T. D. Veit Source Type: journals

Report from the killer immunoglobulin-like receptor (KIR) anthropology component of the 15th International Histocompatibility Workshop: worldwide variation in the KIR loci and further evidence for the co-evolution of KIR and HLAEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The killer immunoglobulin-like receptor (KIR) anthropology component of the 15th International Histocompatibility Workshop (IHIWS) sought to explore worldwide population variation in the KIR loci, and to examine the relationship between KIR genes and their human leukocyte antigen (HLA) ligands. Fifteen laboratories submitted KIR genotype and HLA ligand data in 27 populations from six broad ethnic groups. Data were analyzed for correlations between the frequencies of KIR and their known HLA ligands. In addition, allelic typing was performed for KIR2DL2 and 3DL1 in a subset of populations. Strong and significant correlations...
Source: Tissue Antigens - March 14, 2010 Category: Allergy & Immunology Authors: J. A. Hollenbach, A. Meenagh, C. Sleator, C. Alaez, M. Bengoche, A. Canossi, G. Contreras, L. Creary, I. Evseeva, C. Gorodezky, R.-A. Hardie, T. Hemming Karlsen, B. Lie, M. Luo, M. Martinetti, C. Navarette, D. C. M. de Oliveira, G. Ozzella, A. Pasi, E. Pa Source Type: journals

A novel allele HLA-B*550205 was identified by polymerase chain reaction sequence-based typing in a Chinese individualEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
HLA-B*550205 shows one nucleotide difference from HLA-B*550201 at position 756 in exon 4 from T to C. (Source: Tissue Antigens)
Source: Tissue Antigens - March 14, 2010 Category: Allergy & Immunology Authors: L.-X. Yan, F.-M. Zhu, W. Zhang, H.-J. Lv Source Type: journals

Future Meetings SectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - March 13, 2010 Category: Allergy & Immunology Source Type: journals

The melanocortin receptor agonist NDP-MSH impairs the allostimulatory function of dendritic cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Immunology)
Source: Immunology - March 13, 2010 Category: Allergy & Immunology Authors: Rennalls, LaVerne P.Seidl, ThomasLarkin, James M. G.Wellbrock, ClaudiaGore, Martin E.Eisen, TimBruno, Ludovica Source Type: journals