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Low‐Dose Growth Hormone for 40 Weeks Induces HIV‐1‐Specific T‐Cell Responses in Patients on Effective Combination Antiretroviral Therapy
Summary Recombinant human growth hormone (rhGH) administered to combination antiretroviral therapy (cART)‐treated human immunodeficiency virus‐1 (HIV‐1)‐infected individuals has been found to reverse thymic involution, increase total and naïve CD4 T‐cell counts, and to reduce the expression of activation and apoptosis markers. To‐date, such studies have used high, pharmacological doses of rhGH. In this sub‐study, samples from treated HIV‐1+ subjects, randomised to receive either a physiological dose (0.7mg) of rhGH (n = 21) or placebo (n = 15) daily for 40 weeks, were assessed. Peptide‐based ELISpot assa...
Source: Clinical and Experimental Immunology - May 23, 2013 Category: Allergy & Immunology Authors: Anna A Herasimtschuk, Birgitte R Hansen, Anne Langkilde, Graeme J Moyle, Ove Andersen, Nesrina Imami Tags: Original Article Source Type: research
Polymorphism in the Interleukin‐7 Receptor‐alpha and Outcome after Allogeneic Hematopoietic Cell Transplantation with Matched Unrelated Donor
In conclusion, this study provides further evidence of a role of the IL‐7 pathway and IL‐7Rα SNPs in HCT. This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - May 23, 2013 Category: Allergy & Immunology Authors: Zaiba Shamim, Stephen Spellman, Michael Haagenson, Tao Wang, Stephanie J. Lee, Lars P. Ryder, Klaus Müller Tags: Human Immunology Source Type: research
Characterization of novel CD55 isoforms expression in normal and neoplastic tissues
Abstract CD55 (decay‐accelerating factor, DAF) is overexpressed in several types of cancer, including colorectal cancer. Because of its inhibitory effect on the complement system, it has been suggested as a possible target for cancer immunotherapy. However, CD55 is also expressed in normal tissues, body fluids and stroma, limiting the use of anti‐CD55 therapeutic antibodies. Two novel CD55 splice variants or isoforms have recently been identified. These have been shown to contain part or all of intron 7 (CD55int7+), in contrast to the previously identified splice variants (CD55wt), which do not contain intron 7. Our ai...
Source: Tissue Antigens - May 23, 2013 Category: Allergy & Immunology Authors: E. D. Vainer, K. Meir, M. Furman, I. Semenenko, F. Konikoff, G. W. Vainer Tags: Original article Source Type: research
Offspring IgE Responses are Influenced by Levels of Maternal IgG Transferred in Early Life
ConclusionsHigh compared with low levels of maternal IgG1 were associated with lower TH2 antibody production after adult offspring were re‐exposed to OVA. Thus, offspring allergy‐related responses appeared to be shaped by maternal antibody levels. (Source: American Journal of Reproductive Immunology)
Source: American Journal of Reproductive Immunology - May 23, 2013 Category: Allergy & Immunology Authors: Jitka S. Hansen, Monica Andreassen, Unni C. Nygaard, Martinus Løvik Tags: Original Article Source Type: research
Decrease in antigen‐specific CD63 basophil expression is associated with the development of tolerance to egg by SOTI in children
ConclusionDecrease in Ag‐specific basophil responsiveness is associated with the development of clinical tolerance by SOTI. (Source: Pediatric Allergy and Immunology)
Source: Pediatric Allergy and Immunology - May 23, 2013 Category: Allergy & Immunology Authors: Leticia Vila, Ana Moreno, Pedro M. Gamboa, Rubén Martínez‐Aranguren, Maria L. Sanz Tags: Original Article Source Type: research
Dining out with food allergies
For the millions of Americans with severe life-threatening food allergies, dining out can feel like a minefield. (Source: CNN.com - Health)
Source: CNN.com - Health - May 23, 2013 Category: Consumer Health News Source Type: news
Potential of the trifunctional bispecific antibody surek depends on dendritic cells: rationale for a new approach of tumor immunotherapy.
Abstract Trifunctional bispecific antibodies (trAbs) used in tumor immunotherapy have the unique ability to recruit T cells toward antigens on the tumor cell surface and, moreover, to activate accessory cells through their immunoglobulin Fc region interacting with activating Fcγ receptors. This scenario gives rise to additional costimulatory signals required for T cell-mediated tumor cell destruction and induction of an immunologic memory. Here we show in an in vitro system that most effective trAb-dependent T-cell activation and tumor cell elimination are achieved in the presence of dendritic cells (DCs). On the ...
Source: Molecular Medicine - May 23, 2013 Category: Molecular Biology Authors: Eissler N, Mysliwietz J, Deppisch N, Ruf P, Lindhofer H, Mocikat R Tags: Mol Med Source Type: research
Erythropoietin administration suppresses human monocyte function in vitro and during therapy-induced anemia in HCV patients.
In this study, we examined the immunological effects of EPO on human monocytes. We show that human monocytes express EPO receptor mRNA, and are responsive to EPO in cell culture. In vitro exposure of PBMC from individuals to EPO and the TLR4 ligand LPS showed a significant reduction of monocytes producing IL-6 and TNF, while the frequencies of IL-12p40, IL-10, MIP-1β and IL-8-producing cells did not change upon incubation with EPO. In addition, EPO did increase the phagocytic activity but did not affect the ability to produce ROS by monocytes. Moreover, we studied eight chronic HCV patients undergoing treatment with peg-I...
Source: Antiviral Research - May 23, 2013 Category: Virology Authors: Spaan M, Groothuismink ZM, Koning L, Roomer R, Janssen HL, De Knegt RJ, Boonstra A Tags: Antiviral Res Source Type: research
Previous contact with Strongyloides venezuelensis contributed to prevent insulitis in MLD-STZ diabetes.
In this study we characterized the immune response induced by Strongyloides venezuelensis infection in C57BL/6 mice and then evaluated the effect of a previous contact with this helminth in the outcome of type 1 diabetes. Animals were initially infected with 2000 L3 larvae from S. venezuelensis and euthanized 22days later. An acute phase, identified by a high amount of eggs per gram of feces, was established between days 7 and 9 post-infection. Recovery from infection was associated with a Th2 polarized response characterized by a significant level of serum IgG1 specific antibodies and also a significant production of IL-5...
Source: Experimental Parasitology - May 23, 2013 Category: Parasitology Authors: Peres RS, Chiuso-Minicucci F, da Rosa LC, Domingues A, Zorzella-Pezavento SF, França TG, Ishikawa LL, do Amarante AF, Sartori A Tags: Exp Parasitol Source Type: research
A genetic effect of IL-5 receptor α polymorphism in patients with aspirin-exacerbated respiratory disease.
Abstract Persistent eosinophil activation in both the upper and lower airway mucosa is a central feature of aspirin-exacerbated respiratory disease (AERD). Eosinophil activation and survival are profoundly influenced by interleukin 5 (IL-5) and its receptor, IL-5R. In patients susceptible to allergic disorders, IL-5 receptor α (IL5RA) polymorphisms have been reported; however, an association with AERD remains unclear. We hypothesize that IL5RA polymorphisms may contribute to eosinophil activation in AERD patients. We recruited 139 AERD patients, 171 aspirin-tolerant asthma patients and 160 normal controls. IL5RA p...
Source: exp Mol Med - May 23, 2013 Category: Molecular Biology Authors: Losol P, Kim SH, Seob Shin Y, Min Ye Y, Park HS Tags: Exp Mol Med Source Type: research
Characteristics of polyomavirus BK (BKPyV) infection in primary human urothelial cells.
Abstract High-level polyomavirus BK (BKPyV) replication in urothelial cells is a hallmark of polyomavirus-associated hemorrhagic cystitis (PyVHC), a painful condition affecting bone marrow transplant recipients. In kidney transplant recipients, replication in tubular epithelial cells is associated with overt disease whereas high-level urothelial replication is clinically silent. We characterized BKPyV replication in primary human urothelial cells (HUCs) and compared it to replication in renal tubular epithelial cells (RPTECs). HUCs were easily infected, as shown by expression of T-antigens, VP1-3, and agnoprotein, ...
Source: Virology - May 23, 2013 Category: Virology Authors: Li R, Sharma BN, Linder S, Gutteberg TJ, Hirsch HH, Rinaldo CH Tags: Virology Source Type: research
Oral food desensitization: the BACH proposal for the very gradual reintroduction of a food
Purpose of reviewThe common treatment of IgE-mediated food allergy is to avoid the offending item and educating patients on appropriate emergency measures. Recently, attempts to gain food tolerance with oral administration of increasing doses of the offending food have become frequent. Desensitization procedures are risky and safety is a priority. Their success depends on the individual allergic characteristics and the modality of food administration. Recent findingsMost schedules adopted in the desensitization protocols are empiric and not regular, as requirements of safety would require. SummarySome oral food desensitiza...
Source: Current Opinion in Allergy and Clinical Immunology - May 23, 2013 Category: Allergy & Immunology Tags: FOOD ALLERGY: Edited by Alessandro Fiocchi and Julie Wang Source Type: research
Tissue biopsy monitoring of operational tolerance in liver allograft recipients.
Abstract PURPOSE OF REVIEW: Highly selected, long-surviving, liver allograft recipients with normal/near normal liver injury tests can be weaned from immunosuppression. Baseline biopsies document changes before weaning and can help stratify risk of rejection or dysfunction after weaning; biopsies after weaning are used to study mechanisms of operational tolerance and to monitor for subclinical events. RECENT FINDINGS: Clinicopathological features associated with successful weaning include a lack of sensitization [negative donor-specific antibodies (DSA) and lack of tissue C4d deposits]; 'inexperienced' recipien...
Source: Current Opinion in Organ Transplantation - May 23, 2013 Category: Transplant Surgery Authors: Demetris AJ, Isse K Tags: Curr Opin Organ Transplant Source Type: research
Ferrets, pigs susceptible to H7N9 avian influenza virus
(NIH/National Institute of Allergy and Infectious Diseases) Chinese and US scientists have used a virus isolated from a person who died from H7N9 avian influenza infection to determine whether the virus could infect and be transmitted between ferrets. Ferrets are often used as a mammalian model in influenza research, and efficient transmission of influenza virus between ferrets can provide clues as to how well the same process might occur in people. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 23, 2013 Category: Global & Universal Source Type: news
Differentially Expressed Genes of Human Microvascular Endothelial Cells in Response to Anti-Dengue Virus NS1 Antibodies by Suppression Subtractive Hybridization
Viral Immunology , Vol. 0, No. 0. (Source: Viral Immunology)
Source: Viral Immunology - May 22, 2013 Category: Allergy & Immunology Tags: article Source Type: research
Chapter Three Inflammation in Schizophrenia
Publication date: 2012 Source:Advances in Protein Chemistry and Structural Biology, Volume 88 Author(s): Norbert Müller , Aye-Mu Myint , Markus J. Schwarz Although there is no doubt that the dopaminergic neurotransmission is strongly involved in the pathophysiology of schizophrenia, the exact mechanism leading to dopaminergic dysfunction is still unclear. A disbalance in the immune response associated with a slight inflammatory process of the central nervous system (CNS) has been postulated. Such a mechanism is the basis for the “mild encephalitis” concept. A dysfunction in the activation of the type-1 immune respon...
Source: Advances in Protein Chemistry and Structural Biology - May 22, 2013 Category: Biochemistry Source Type: research
Stress Biology and Immunology in Nephrops norvegicus.
Abstract The Norway lobster Nephrops norvegicus lives at low-light depths, in muddy substrata of high organic content where water salinities are high and fluctuations in temperature are moderate. In this environment, the lobsters are naturally exposed to a number of potential stressors, many of them as a result of the surficial breakdown of organic material in the sediment. This process (early diagenesis) creates a heterogeneous environment with temporal and spatial fluctuations in a number of compounds such as oxygen, ammonia, metals, and hydrogen sulphide. In addition to this, there are anthropogenically generate...
Source: Advances in Marine Biology - May 22, 2013 Category: Biology Authors: Eriksson SP, Hernroth B, Baden SP Tags: Adv Mar Biol Source Type: research
Raman spectroscopy and imaging: promising optical diagnostic tools in pediatrics.
Abstract This review focuses on the use of Raman spectroscopy, an analytical technique based on the inelastic scattering of harmless laser light with biological tissues, as an innovative diagnostic tool in pediatrics. After a brief introduction to explain the fundamental concepts behind Raman spectroscopy and imaging, a short summary is given of the most important and common issues arising when handling spectral data with multivariate statistics. Then, the most relevant papers in which Raman spectroscopy or imaging has been applied with diagnostic purposes to pediatric patients are reviewed, and grouped according t...
Source: Current Medicinal Chemistry - May 22, 2013 Category: Chemistry Authors: Beleites C, Bonifacio A, Codrich D, Krafft C, Sergo V Tags: Curr Med Chem Source Type: research
Immunomodulatory properties of farnesoids: the new steroids?
Abstract Farnesylthiosalisylic acid (FTS) is a potent non-toxic anticancer drug that targets oncogenic and pathologically activated Ras. The mechanism of action of FTS is well understood. It interferes with the binding of activated Ras proteins to their escort chaperons and with Ras tethering to the plasma membrane. This agent has been evaluated successfully in phase II clinical trials of pancreatic and lung cancer patients. It is generally agreed that Ras proteins play an important role in cancer, but they also drive activation of the immune system. Therefore we hypothesized that inhibiting Ras might be beneficial...
Source: Current Medicinal Chemistry - May 22, 2013 Category: Chemistry Authors: Mor A, Aizman E, Chapman J, Kloog Y Tags: Curr Med Chem Source Type: research
Immunotoxicological effects of inorganic arsenic on gilthead seabream (Sparus aurata L.).
Abstract Arsenic (As) has been associated with multitude of animal and human health problems; however, its impact on host immune system has not been extensively investigated. In fish, there are very few works on the potential risks or problems associated to the presence of arsenic. In the present study we have evaluated the effects of exposure (30 days) to sub-lethal concentrations of arsenic (5μM As2O3) in the teleost fish gilthead seabream (Sparus aurata), with special emphasis in the innate immune response. The arsenic concentration was determined using atomic fluorescence spectrometry (AFS) in liver and muscle...
Source: Aquatic Toxicology - May 22, 2013 Category: Toxicology Authors: Guardiola FA, Gónzalez-Párraga MP, Cuesta A, Meseguer J, Martínez S, Martínez-Sánchez MJ, Pérez-Sirvent C, Esteban MA Tags: Aquat Toxicol Source Type: research
Berberine attenuates bleomycin induced pulmonary toxicity and fibrosis via suppressing NF-κB dependant TGF-β activation: A biphasic experimental study.
This study was hypothesized to investigate the antifibrotic potential of berberine against bleomycin-induced lung injury and fibrosis, a tentative animal model. Male wistar rats were subjected to single intratracheal instillation of 2.5U/kg of bleomycin on day 0. Berberine treatments were either provided in preventive or therapeutic mode respectively. Berberine administration significantly ameliorated the bleomycin mediated histological alterations and reduced the inflammatory cell infiltrate in BALF. Berberine significantly blocked collagen accumulations with parallel reduction in the hydroxyproline level. The immunologic...
Source: Toxicology Letters - May 22, 2013 Category: Toxicology Authors: Chitra P, Saiprasad G, Manikandan R, Sudhandiran G Tags: Toxicol Lett Source Type: research
Modulation of membrane phospholipids, the cytosolic calcium influx and cell proliferation following treatment of B16-F10 cells with recombinant phospholipase-D from Loxosceles intermedia (brown spider) venom.
Abstract The mechanism through which brown spiders (Loxosceles genus) cause dermonecrosis, dysregulated inflammatory responses, hemolysis and platelet aggregation, which are effects reported following spider bites, is currently attributed to the presence of phospholipase-D in the venom. In the present investigation, through two-dimensional immunoblotting, we observed immunological cross-reactivity for at least 25 spots in crude Loxosceles intermedia venom, indicating high expression levels for different isoforms of phospholipase-D. Using a recombinant phospholipase-D from the venom gland of L. intermedia (LiRecDT1)...
Source: Toxicon - May 22, 2013 Category: Toxicology Authors: Wille AC, Chaves-Moreira D, Trevisan-Silva D, Magnoni MG, Boia-Ferreira M, Gremski LH, Gremski W, Chaim OM, Senff-Ribeiro A, Veiga SS Tags: Toxicon Source Type: research
Prevalence of contact allergy in children suffering from atopic dermatitis, seborrhoeic dermatitis and in healthy controls.
CONCLUSIONS: The statistically significant positive results in the highest proportion of patch tests in the youngest age subpopulation of children with atopic dermatitis, and detection of contact allergy most commonly in the youngest subgroup of healthy children, may suggest nonspecifically positive results associated with the immaturity of the epidermal barrier during the first years of life. Concentrations of contact allergens included in current pediatric sets of patch tests seems to be too high and should be verified. PMID: 23540212 [PubMed - in process] (Source: Annals of Agricultural and Environmental Medicine : AAEM)
Source: Annals of Agricultural and Environmental Medicine : AAEM - May 22, 2013 Category: Environmental Health Authors: Silny W, Bartoszak L, Jenerowicz D, Żukiewicz-Sobczak W, Goździewska M Tags: Ann Agric Environ Med Source Type: research
Forecasting of the selected features of Poaceae (R. Br.) Barnh., Artemisia L. and Ambrosia L. pollen season in Szczecin, north-western Poland, using Gumbel's distribution.
CONCLUSIONS: Short pollen seasons are characterised by a higher intensity of pollination than long ones. Prediction of the maximum pollen count values, dates of the pollen season beginning, and the number of days with pollen count above the threshold, on the basis of Gumbel's distribution, is expected to lead to improvement in the prophylaxis and therapy of persons allergic to pollen. PMID: 23540210 [PubMed - in process] (Source: Annals of Agricultural and Environmental Medicine : AAEM)
Source: Annals of Agricultural and Environmental Medicine : AAEM - May 22, 2013 Category: Environmental Health Authors: Puc M, Wolski T Tags: Ann Agric Environ Med Source Type: research
Ongoing Risk Behavior and the Presence of HCV-RNA Affect the Hepatitis C Virus (HCV)-Specific CD4+ T Cell Response
Viral Immunology , Vol. 0, No. 0. (Source: Viral Immunology)
Source: Viral Immunology - May 22, 2013 Category: Allergy & Immunology Tags: article Source Type: research
Resveratrol role in Staphylococcus aureus‐induced corneal inflammation
This article is protected by copyright. All rights reserved. (Source: FEMS Immunology and Medical Microbiology)
Source: FEMS Immunology and Medical Microbiology - May 22, 2013 Category: Microbiology Authors: Andreana Marino, Giuseppe Santoro, Francesca Spataro, Eugenia R. Lauriano, Simona Pergolizzi, Francesco Cimino, Antonio Speciale, Antonia Nostro, Giuseppe Bisignano, Giacomo Dugo Tags: Short Communications Source Type: research
Progress after recent breakthrough which opened new chapter in anti-cancer cell therapies
(John Theurer Cancer Center) John Theurer Cancer Center at Hackensack University Medical Center, one of the nation's top 50 cancer centers, will bring together leading cancer experts, for presentation and discussion of the latest developments and implications of cell therapy and interventional immunology in oncology, on Friday, June 7 from 7:00am to 1:30pm. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 22, 2013 Category: Global & Universal Source Type: news
Novel approach for influenza vaccination shows promise in early animal testing
(NIH/National Institute of Allergy and Infectious Diseases) A new approach for immunizing against influenza elicited a more potent immune response and broader protection than the currently licensed seasonal influenza vaccines when tested in mice and ferrets. The vaccine concept, which was developed by scientists at NIAID, represents an important step forward in the quest to develop a universal influenza vaccine -- one that would protect against most or all influenza strains without the need for an annual vaccination. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 22, 2013 Category: Global & Universal Source Type: news
Effect of Branched α‐Oligomannoside Structures on Induction of Anti‐Candida Humoral Immune Response
In this study, we analysed humoral immune response induced by immunization with BSA‐based conjugates bearing synthetic α‐1,6‐branched oligomannosides (pentamannosides (M5) or hexamannosides (M6)) mimicking antigenic sequences of Candida cell wall mannan. We analysed the ability of antibodies prepared by immunization to recognize relevant antigenic determinants in mannan polysaccharide structure and in C. albicans yeast and hyphal morphoforms. M6‐BSA conjugate induced markedly higher levels of mannan‐specific IgG compared with M5‐BSA conjugate. In contrast to M5‐BSA conjugate, M6‐BSA conjugate induced immu...
Source: Scandinavian Journal of Immunology - May 22, 2013 Category: Allergy & Immunology Authors: L. Paulovičová, E. Paulovičová, A. A. Karelin, Y. E. Tsvetkov, N. E. Nifantiev, S. Bystrický Tags: Experimental Immunology Source Type: research
Interaction of Mycobacterium tuberculosis Cell Wall Components with the Human Natural Killer Cell Receptors NKp44 and Toll‐Like Receptor 2
Abstract We have previously demonstrated that a soluble form of the human NK cell natural cytotoxicity receptor NKp44, binds to the surface of Mycobacterium tuberculosis (MTB). Herein, we investigated the interaction of MTB cell wall components (CWC) with NKp44 or with Toll‐like receptor 2 (TLR2) and the role of NKp44 and TLR2 in the direct activation of NK cells upon stimulation with MTB CWC. By using several purified bacterial CWC in an ELISA, we demonstrated that NKp44 was able to bind to the MTB cell wall core mycolyl‐arabinogalactan‐peptidoglycan (mAGP) as well as to mycolic acids (MA) and arabinogalactan (AG), ...
Source: Scandinavian Journal of Immunology - May 22, 2013 Category: Allergy & Immunology Authors: S. Esin, C. Counoupas, A. Aulicino, F. L. Brancatisano, G. Maisetta, D. Bottai, M. Luca, W. Florio, M. Campa, G. Batoni Tags: Experimental Immunology Source Type: research
Variability of Memory B cell Markers in a Cohort of Common Variable Immune Deficiency Patients over 6 months
Abstract Common Variable Immunodeficiency Disorder (CVID) is a complex disorder that predisposes patients to recurrent and severe infections. Immunophenotypic classification schemes were developed to categorize patients with CVID into phenotypic and prognostic groups based on different memory B cell subsets. Whether the B cell subset analysis is stable over time has not been investigated. B cell phenotyping in patients with CVID (n = 15) and sex‐ and age‐matched controls (n = 26) were carried out according to the three B cell classifications. Patients with CVID were evaluated monthly over 6 months. Controls were a...
Source: Scandinavian Journal of Immunology - May 22, 2013 Category: Allergy & Immunology Authors: W. Koopmans, S.‐T. Woon, I. S. L. Zeng, A. Jordan, S. Brothers, P. Browett, R. Ameratunga Tags: Human Immunology Source Type: research
Diagnostic Yield of Heat Shock Protein 70 (HSP‐70) and Anti‐HSP‐70 in Behcet‐Induced Uveitis
Abstract Heat shock proteins (HSPs) are intracellular proteins with pro‐ and anti‐inflammatory actions, playing an important role in the pathogenesis of Behcet's disease (BD). Diagnosis of BD uveitis in early stages is still problematic, thus this study was undertaken to determine diagnostic values of serum HSP‐ and anti‐HSP‐70 in BD uveitis. Serum levels of HSP‐ and anti‐HSP‐70 were measured in 53 patients with BD (26 with and 27 without uveitis). In control group, 25 age‐ and sex‐matched idiopathic uveitis patients were enrolled consecutively. Both groups had no medical problems save uveitis at the ti...
Source: Scandinavian Journal of Immunology - May 22, 2013 Category: Allergy & Immunology Authors: M. Sahebari, K. Hashemzadeh, M. Mahmoudi, Z. Saremi, Z. Mirfeizi Tags: Human Immunology Source Type: research
Neonatal folate, homocysteine, vitamin B12 levels and methylenetetrahydrofolate reductase variants in childhood asthma and eczema
ConclusionsFolate, homocysteine and vitamin B12 levels of children at birth did not affect asthma‐ and eczema‐related outcomes up to the age of 6 years. Further studies are warranted to establish the role of MTHFR variants in these associations. (Source: Allergy)
Source: Allergy - May 22, 2013 Category: Allergy & Immunology Authors: R. J. P. Valk, J. C. Kiefte‐de Jong, A. M. M. Sonnenschein‐van der Voort, L. Duijts, E. Hafkamp‐de Groen, H. A. Moll, H. Tiemeier, E. A. P. Steegers, A. Hofman, V. W. V. Jaddoe, J. C. Jongste Tags: Original Article Source Type: research
CEACAM1 on activated NK cells inhibits NKG2D‐mediated cytolytic function and signaling
This article is protected by copyright. All rights reserved (Source: European Journal of Immunology)
Source: European Journal of Immunology - May 22, 2013 Category: Allergy & Immunology Authors: Shuhei Hosomi, Zhangguo Chen, Kristi Baker, Lanfen Chen, Yu‐Hwa Huang, Torsten Olszak, Sebastian Zeissig, Jing H. Wang, Ofer Mandelboim, Nicole Beauchemin, Lewis L. Lanier, Richard S. Blumberg Tags: Regular Article Source Type: research
Positive selection of self‐antigen‐specific CD8+ T cells by hematopoietic cells
In contrast to thymic epithelial cells, which induce the positive selection of conventional CD8+ T cells, hematopoietic cells (HCs) select innate CD8+ T cells whose Ag specificity is not fully understood. Here we show that CD8+ T cells expressing an H‐Y Ag‐specific Tg TCR were able to develop in mice in which only HCs expressed MHC class I, when HCs also expressed the H‐Y Ag. These HC‐selected self‐specific CD8+ T cells resemble innate CD8+ T cells in WT mice in terms of the expression of memory markers and effector functions, but are phenotypically distinct from the thymus‐independent CD8+ T‐cell population....
Source: European Journal of Immunology - May 22, 2013 Category: Allergy & Immunology Authors: Hisakata Yamada, Kensuke Shibata, Koji Sakuraba, Kenjiro Fujimura, Yasunobu Yoshikai Tags: Regular Article Source Type: research
5-Day Steroid Tx Works in COPD (CME/CE)
PHILADELPHIA (MedPage Today) -- A 5-day course of systemic glucocorticoid therapy in patients with acute chronic obstructive pulmonary disease was as effective as 14-day treatment, researchers reported here. (Source: MedPage Today Allergy)
Source: MedPage Today Allergy - May 21, 2013 Category: Allergy & Immunology Source Type: news