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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 35.

Component‐resolved diagnosis of wasp (yellow jacket) venom allergy
ConclusionComponent‐resolved diagnoses with the wasp‐specific recombinant allergen components Ves v 1 and Ves v 5 is a reliable method to diagnose yellow jacket allergy and can help to take out the sting of difficult cases. However, as the number of patients with doubt after conventional tests is small, larger collaborative studies are needed to draw more definitive conclusions. Whether the rVes v 5 supplemented yellow jacket allergosorbent constitutes an asset in the diagnostic management of wasp venom allergy remains to be further established.
Source: Clinical and Experimental Allergy - January 18, 2013 Category: Allergy & Immunology Authors: D. G. Ebo, M. Faber, V. Sabato, J. Leysen, C. H. Bridts, L. S. Clerck Tags: Original Article Source Type: research

House dust mite sublingual immunotherapy: a double‐blind, placebo‐controlled study in elderly patients with allergic rhinitis
Conclusions & Clinical RelevanceSublingual allergen‐specific immunotherapy in elderly patients with a HDM allergy to D. pteronyssinus and D. farinae generated a significant clinical improvement in the active group compared with the placebo group, particularly during the heating season. This therapy was well tolerated.
Source: Clinical and Experimental Allergy - January 18, 2013 Category: Allergy & Immunology Authors: A. Bozek, B. Ignasiak, B. Filipowska, J. Jarzab Tags: Original Article Source Type: research

The 5‐lipoxygenase‐activating protein inhibitor, GSK2190915, attenuates the early and late responses to inhaled allergen in mild asthma
Conclusion and Clinical RelevanceGSK2190915 shows potential as a treatment for patients with asthma.
Source: Clinical and Experimental Allergy - January 18, 2013 Category: Allergy & Immunology Authors: S. E. Kent, M. Boyce, Z. Diamant, D. Singh, B. J. O'Connor, P. S. Saggu, V. Norris Tags: Original Article Source Type: research

Allergen bronchoprovocation and chitinases in allergic asthma
Source: Clinical and Experimental Allergy - January 18, 2013 Category: Allergy & Immunology Authors: G. M. Gauvreau Tags: Editorial Source Type: research

Asthma in school‐aged children, it's time to reveal its entities
Source: Clinical and Experimental Allergy - January 18, 2013 Category: Allergy & Immunology Authors: A. H. Poon Tags: Editorial Source Type: research

The Editor takes a closer look at some of this month's articles
Source: Clinical and Experimental Allergy - January 18, 2013 Category: Allergy & Immunology Tags: Editor's Choice Source Type: research

Serum metabolomics reveals pathways and biomarkers associated with asthma pathogenesis
Conclusion & Clinical RelevanceThese data showed that 1H‐NMR‐based metabolite profiling of serum may be useful for the effective diagnosis of asthma and a further understanding of its pathogenesis.© 2013 Blackwell Publishing Ltd
Source: Clinical and Experimental Allergy - January 18, 2013 Category: Allergy & Immunology Authors: Jeeyoun Jung, Seung‐Hyun Kim, Ho‐Sub Lee, Gil Soon Choi, Young‐Sang Jung, Do Hyun Ryu, Hae‐Sim Park, Geum‐Sook Hwang Tags: Original Article‐Asthma and Rhinitis Source Type: research

Performance of two Aspergillus IgG EIA assays compared with the precipitin test in chronic and allergic aspergillosis
This study assessed the performance of two commercial EIAs compared with counterimmunoelectrophoresis (CIE). This was a prospective cohort study of 175 adult patients with chronic or allergic pulmonary aspergillosis. Aspergillus IgG antibodies were detected using CIE, Phadia ImmunoCap Aspergillus IgG and Bio‐Rad Platelia Aspergillus IgG. Inter‐assay reproducibility was determined for each method and 25 patients had two serum samples analysed within a 6‐month interval. When compared with CIE, both ImmunoCap and Platelia Aspergillus IgG had good sensitivity (97 and 93%, respectively) for detection of Aspergillus IgG an...
Source: Clinical Microbiology and Infection - January 18, 2013 Category: Microbiology Authors: C. G. Baxter, D. W. Denning, A. M. Jones, A. Todd, C. B. Moore, M. D. Richardson Tags: Original Article Source Type: research

UPDATED - Allergy Alert – UNDECLARED EGGS in Kinnikinnick Foods Frozen Pie Crust
Kinnikinnick Foods of 10940 120 street, Edmonton, AB is warning consumers with Egg Allergies not to consume Kinnikinnick Frozen Pie Crust because it contains EGG products which may not be indicated on an applied ingredient label. Products without an ingredient label applied to the box are not subject to this recall as they correctly list the product as containing eggs.
Source: Food and Drug Administration - January 17, 2013 Category: Food Science Source Type: news

[Pneumocystosis in a patient with lymphangioleiomyomatosis.]
Abstract A 47-year-old, non-smoking woman was admitted to the National Tuberculosis and Lung Diseases Research Institute for diagnosis of progressive exertional dyspnoea and numerous small thin-walled, air-filled cysts equally distributed throughout both lungs revealed in HRCT (high resolution computed tomography) examination. Histological assessment of specimens obtained by open lung biopsy revealed proliferation of immature smooth muscle, showing the expression of the antigen HMB45. On this basis, diagnosis of lymphangioleiomyomatosis was established. The disease caused essential ventilation damage of the lungs (...
Source: Pneumonologia i Alergologia Polska - January 17, 2013 Category: Respiratory Medicine Authors: Mydłowski T, Radzikowska E, Oniszh K, Szczepulska-Wójcik E, Jaguś P, Wiatr E Tags: Pneumonol Alergol Pol Source Type: research

Oxazolone and Ethanol Induce Colitis in NOD‐scid IL2R γnull Mice Engrafted with Human Peripheral Blood Mononuclear Cells
In this study, we examined the induction of oxazolone mediated colitis in NOD‐scid IL2Rγ null mice engrafted with human peripheral blood mononuclear cells (hPBMC) derived from patients suffering from ulcerative colitis (UC), atopic dermatitis (AD) and healthy volunteers. NOD‐scid IL2Rγ null mice were engrafted with hPBMC followed by challenge with oxazolone or ethanol vehicle. Mice developed the same symptoms as previously observed in immune‐competent mice. The clinical activity score increased and the colon architecture was characterized by the development of edema, fibrosis, crypt loss and dense infiltration of p...
Source: Clinical and Experimental Immunology - January 17, 2013 Category: Allergy & Immunology Authors: Thomas Nolte, Maryam Zadeh‐ Khorasani, Orkhan Safarov, Franziska Rueff, Veit Gülberg, Nadja Herbach, Andreas Wollenberg, Thomas Mueller, Matthias Siebeck, Eckhard Wolf, Roswitha Gropp Tags: Original Article Source Type: research

Asthma, Low Birth Weight Not LinkedAsthma, Low Birth Weight Not Linked
Using a propensity score to adjust for covariates, a new study has found that there is no association between birth weight and the risk of developing childhood asthma. Medscape Medical News
Source: Medscape Today Headlines - January 17, 2013 Category: Consumer Health News Tags: Allergy & Clinical Immunology News Source Type: news

Americans Sicker Compared To Other Wealthy Nations
This report shows where the differences and disparities exist and who bears the greatest burden, but they don’t tell us why these differences exist,” she says. SOURCES:National Research Council and Institute of Medicine report: “U.S. Health in International Perspective: Shorter Lives, Poorer Health.”Jacqueline Moline, MD, vice president, population health, North Shore/Long Island Jewish Health System, Great Neck, N.Y.Steven H. Woolf, MD, MPH, professor, family medicine, Virginia Commonwealth University, Richmond, Va.Ana V. Diez-Roux, MD, PhD, MPH, professor and chair, epidemiology; director...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - January 17, 2013 Category: Consumer Health News Authors: mreal197 Tags: WebMD News Source Type: news

Vicar allergic to lilies takes early retirement
A vicar who is allergic to lilies has taken early retirement on ill health grounds.
Source: Telegraph Health - January 17, 2013 Category: Consumer Health News Source Type: news

Vicar allergic to lilies forced out of job
A vicar who is allergic to lilies has taken early retirement on ill health grounds as he cannot conduct funerals.
Source: Telegraph Health - January 17, 2013 Category: Consumer Health News Source Type: news

Fecal transplants successful in treating intestinal ailment
An infusion of feces from a healthy person is much more effective than an antibiotic in treating C. difficile , a recurrent intestinal infection, researchers find.A new study has found that an infusion of feces from a healthy person into an ailing patient's gut was significantly more effective than a traditional antibiotic treatment — raising hopes that the unconventional approach could one day help combat obesity, food allergies and a host of other maladies.
Source: Los Angeles Times - Science - January 17, 2013 Category: Science Source Type: news

The regulatory effect of veratric acid on NO production in LPS-stimulated RAW264.7 macrophage cells.
This study was designed to evaluate the inhibitory effects of veratric acid on nitric oxide (NO) production in LPS-stimulated RAW264.7 cells. It was found that veratric acid inhibited NO production and inducible nitric oxide synthase (iNOS) expression in LPS-stimulated RAW264.7 cells. The inhibitory effects of veratric acid on the generation of interleukin-6 (IL-6) and interferon-γ (IFN-γ) was determined. Furthermore, veratric acid facilitated the inactivation of glycogen synthase kinase-3β (GSK-3β), STAT-1, and STAT-3 in dose-dependent manner. Notably, NF-κB and members of the mitogen activated protein kinase (MAPK) ...
Source: Cellular Immunology - January 17, 2013 Category: Allergy & Immunology Authors: Choi WS, Shin PG, Lee JH, Kim GD Tags: Cell Immunol Source Type: research

Production of Serotonin by Tryptophan Hydroxylase 1 andRelease via Platelets Contribute to Allergic Airway Inflammation.
CONCLUSION: In summary, TPH1-deficiency or -inhibition reduces AAI. Platelet- and not mast cell-derived 5-HT is pivotal in AAI, and lack of 5-HT leads to an impaired Th2-priming capacity of BMDC. Thus, targeting TPH1 could offer novel therapeutic options for asthma. PMID: 23328530 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 17, 2013 Category: Respiratory Medicine Authors: Dürk T, Duerschmied D, Müller T, Grimm M, Reuter S, Paula Vieira R, Ayata K, Cicko S, Sorichter S, Walther DJ, Virchow JC, Taube C, Idzko M Tags: Am J Respir Crit Care Med Source Type: research

Allele-Specific siRNA Silencing for the Common Keratin 12 Founder Mutation in Meesmann Epithelial Corneal Dystrophy [Cornea]
Conclusions. A potent allele-specific siRNA against the K12 Arg135Thr mutation was identified. In combination with efficient eyedrop formulation delivery, this would represent a personalized medicine approach, aimed at preventing the pathology associated with MECD and other ocular surface pathologies with dominant-negative or gain-of-function pathomechanisms.
Source: Investigative Ophthalmology - January 17, 2013 Category: Opthalmology Authors: Allen, E. H. A., Atkinson, S. D., Liao, H., Moore, J. E., Leslie Pedrioli, D. M., Smith, F. J. D., McLean, W. H. I., Moore, C. B. T. Tags: Cornea Source Type: research

Molecular Control of Steady-State Dendritic Cell Maturation and Immune Homeostasis.
Abstract Dendritic cells (DCs) are specialized sentinels responsible for coordinating adaptive immunity. This function is dependent upon coupled sensitivity to environmental signs of inflammation and infection to cellular maturation-the programmed alteration of DC phenotype and function to enhance immune cell activation. Although DCs are thus well equipped to respond to pathogens, maturation triggers are not unique to infection. Given that immune cells are exquisitely sensitive to the biological functions of DCs, we now appreciate that multiple layers of suppression are required to restrict the environmental sensit...
Source: Annual Review of Immunology - January 17, 2013 Category: Allergy & Immunology Authors: Hammer GE, Ma A Tags: Annu Rev Immunol Source Type: research

The majority of T cells, including T(reg) cells, are developed from CD4(-)CD8(-) T progenitor cells without the involvement of the CD4(+)CD8(+) stage in the thymus.
In this study, we examined CD4(-)CD8(-) (DN) cells as precursors of T cells. We provided evidence that DN-CD25(+) T cells could express the gene encoding forkhead box P3 (Foxp3) at high levels but were unable to express genes for T cell receptor (TCR) and cluster of differentiation 3 (CD3). In contrast, DN-CD25(-) cells could express and produce TCR and CD3 but not Foxp3. Furthermore, DN cells exhibited a higher-level expression of cell surface marker CD25, as well as Foxp3, but reduced expression of CD44, CD3, and TCR when compared to CD4(+)CD8(-) T cells. In the process of T cell development in the thymus, we noted that ...
Source: Developmental and Comparative Immunology - January 17, 2013 Category: Allergy & Immunology Authors: Liu T, Huo X, Liu G, Chopra AK Tags: Dev Comp Immunol Source Type: research

The immune system's involvement in obesity-driven type 2 diabetes.
Abstract Type 2 diabetes is now a worldwide epidemic, strongly correlated with an elevated incidence of obesity. Obesity-associated adipose tissue inflammation is a major cause of the decreased insulin sensitivity seen in type 2 diabetes. Recent studies have shed light on the cross-talk between the immune system and organismal metabolism. This review discusses the connection between inflammation in adipose tissue and systemic insulin resistance, focusing on the roles of innate and adaptive immune cell subsets in the pathogenesis of this metabolic disease. PMID: 23333525 [PubMed - as supplied by publisher]
Source: Seminars in Immunology - January 17, 2013 Category: Allergy & Immunology Authors: Shu CJ, Benoist C, Mathis D Tags: Semin Immunol Source Type: research

Dendritic cells administered intrarectally penetrate the intestinal barrier to break intestinal tolerance via Th2-medeiated colitis in mice.
Abstract Intestinal lamina propria dendritic cells (LPDCs) in mice are known to extend dendrites between the intestinal epithelia and the luminal side when processing luminal antigens. We conducted intrarectal cell transfer experiments of bone marrow-derived dendritic cells (BMDCs) in mice to assess dendritic cell penetration of the intestine. Intrarectally administered GFP(+) BMDCs localized in the colonic LP within 3h and the spleen within 12h after administration. 72h after administration, recipient C57BL/6 mice showed acute diarrhea, and administration of BMDCs (once weekly for 3 week) induced intestinal inflam...
Source: Immunology Letters - January 17, 2013 Category: Allergy & Immunology Authors: Handa T, Kanai T, Sato T, Mikami Y, Sujino T, Hayashi A, Mizuno S, Matsumoto A, Hisamatsu T, Hibi T Tags: Immunol Lett Source Type: research

Guidelines for the use of human immunoglobulin therapy in patients with primary immunodeficiencies in Latin America.
Abstract Antibodies are an essential component of the adaptative immune response and hold long-term memory of the immunological experiences throughout life. Antibody defects represent approximately half of the well-known primary immunodeficiencies requiring immunoglobulin replacement therapy. In this article, the authors review the current indications and therapeutic protocols in the Latin American environment. Immunoglobulin replacement therapy has been a safe procedure that induces dramatic positive changes in the clinical outcome of patients who carry antibody defects. PMID: 23333411 [PubMed - as supplied by publisher]
Source: Allergologia et Immunopathologia - January 17, 2013 Category: Allergy & Immunology Authors: Condino-Neto A, Costa-Carvalho BT, Grumach AS, King A, Bezrodnik L, Oleastro M, Leiva L, Madrigal OP, Espinosa-Rosales FJ, Franco JL, Sorensen RU Tags: Allergol Immunopathol (Madr) Source Type: research

Maintenance of Host Leukocytes in Peripheral Immune Compartments Following Lethal Irradiation and Bone Marrow Reconstitution: Implications for Graft Versus Host Disease.
Abstract Bone marrow reconstitution is utilized as a tool for disease treatment and as a research technique to elucidate the function of bone marrow derived cells. Clinically successful engraftment is indicated by the development of a functioning immune repertoire. In research, reconstitution is considered successful if >85% of splenic leukocytes are of donor origins. Previous work suggests that splenic reconstitution may not be indicative of reconstitution in the mucosa. We sought to evaluate mucosal reconstitution in animals following a standard bone marrow eradication and reconstitution technique. Bone marrow...
Source: Transplant Immunology - January 17, 2013 Category: Transplant Surgery Authors: Staley EM, Tanner SM, Daft JG, Stanus AL, Martin SM, Lorenz RG Tags: Transpl Immunol Source Type: research

KCNE gene expression is dependent on the proliferation and mode of activation of leukocytes.
Abstract Voltage-dependent K (+) (Kv) channels are tightly regulated during the immune system response. Leukocytes have a limited repertoire of Kv channels, whose physiological role is under intense investigation. A functional Kv channel is an oligomeric complex composed of pore-forming and ancillary subunits. The KCNE gene family is a novel group of modulatory Kv channel elements in leukocytes. Here, we characterized the gene expression of KCNEs (1-5) in leukocytes and investigated their regulation during leukocyte proliferation and mode of activation. Murine bone-marrow-derived macrophages, human Jurkat T-lymphoc...
Source: Channels - January 17, 2013 Category: Molecular Biology Authors: Solé L, Vallejo-Gracia A, Roig SR, Serrano-Albarrás A, Marruecos L, Manils J, Gómez D, Soler C, Felipe A Tags: Channels (Austin) Source Type: research

HLA‐DRB1 Typing by Micro‐Bead Array Assay Identifies the Origin of Early Lymphoproliferative Disorder in a Heart Transplant Recipient
We report the case of a 68‐year‐old woman who underwent heart transplantation for hypertrophic cardiomyopathy. Two months after the transplant she developed mild fever and dyspnea with a marked drop in left ventricle ejection fraction of 31%. Coronary angiography was negative for cardiac allograft vasculopathy. Endomyocardial biopsy revealed ischemic damage with no evidence of acute cellular rejection, antibody‐mediated rejection or viral myocarditis. A neoplastic process was suspected even though full‐body computerized tomography was negative for malignancy. The patient died 4 months after transplantation. The aut...
Source: American Journal of Transplantation - January 17, 2013 Category: Transplant Surgery Authors: M. Fedrigo, F. Poli, G. Esposito, G. Feltrin, G. Toscano, C. d'Agostino, B. Schiavon, G. Gerosa, A. Amadori, M. Valente, G. Thiene, A. Angelini Tags: Case Report Source Type: research

Screening and treating pulmonary arterial hypertension in a tertiary hospital‐based multidisciplinary clinic: the first 200 patients
ConclusionA multidisciplinary clinic can provide efficient diagnosis and rapid triage to PAH‐specific therapy, if appropriate. Retention rates remain high, at follow up.
Source: Internal Medicine Journal - January 17, 2013 Category: Internal Medicine Authors: A. J. Low, D. Fowler, M. K. Manghani, I. Young, R. Garsia, P. Torzillo, P. Youssef, D. S. Celermajer Tags: Original Article Source Type: research

Antibiotics may not improve short-term or long-term outcomes in acute uncomplicated diverticulitis
This study evaluates whether or not antibiotic therapy for acute uncomplicated left-sided diverticulitis improves recovery. Methods A non-blinded randomised clinical trial comparing treatment of acute uncomplicated left-sided diverticulitis with or without antibiotics was performed. Adult patients were enrolled if they had a history and clinical signs of acute diverticulitis, a raised white cell count (WCC) and...
Source: Evidence-Based Medicine - January 17, 2013 Category: Internal Medicine Authors: Westwood, D. A., Eglinton, T. W. Tags: Inflammatory bowel disease, Clinical trials (epidemiology), Immunology (including allergy), Pain (neurology), Chemotherapy, Radiology, Clinical diagnostic tests, Radiology (diagnostics) Therapeutics Source Type: research

A 10-day course of amoxicillin does not reduce symptoms of acute rhinosinusitis at day 3 of treatment
Commentary on: Garbutt JM, Banister C, Spitznagel E, et al.. Amoxicillin for acute rhinosinusitis: a randomized controlled trial. JAMA 2012;307:685–92 . Context Despite the controversy regarding their clinical benefit and concerns about resistance, the use of antimicrobials for rhinosinusitis (RS) accounts for one in five prescriptions for adults in the USA. However, we lack a simple diagnostic or predictive tool for determining whether acute viral RS has progressed to secondary bacterial RS, and must therefore rely on a patient's history and limited physical findings to diagnose RS. Using guidelines recommended by a...
Source: Evidence-Based Medicine - January 17, 2013 Category: Internal Medicine Authors: Anon, J., Ferguson, B. J., Jacobs, M. R. Tags: Clinical trials (epidemiology), Immunology (including allergy), Otitis, Headache (including migraine), Pain (neurology), Ear, nose and throat/otolaryngology Therapeutics Source Type: research

In patients with a first episode of severe alcoholic hepatitis non-responsive to medical therapy, early liver transplant increases 6-month survival
Commentary on: Mathurin P, Moreno C, Samuel D, et al.. Early liver transplantation for severe alcoholic hepatitis. N Engl J Med 2011;365:1790–800. Context In its most severe form, alcoholic hepatitis is associated with jaundice, coagulopathy, leucocytosis and rapid deterioration to death.1 When used in conjunction with abstinence from alcohol, corticosteroids improve 6-month survival for such severely affected patients.2 Treatment failures are identified after 7 days of therapy, using a simple mathematical instrument (http://www.lillemodel.com).3 Patients with alcoholic hepatitis who are unresponsive to medical manag...
Source: Evidence-Based Medicine - January 17, 2013 Category: Internal Medicine Authors: Lucey, M. R. Tags: Liver disease, Epidemiologic studies, Immunology (including allergy), Hepatitis and other GI infections, Radiology, Hepatitis (sexual health), Surgical diagnostic tests, Clinical diagnostic tests Therapeutics Source Type: research

Occupational allergic rhinoconjunctivitis and bronchial asthma induced by goat cheese
Occupational asthma represents 25% of cases of occupational lung disease and 5–10% of cases of asthma in adults.1 A 49-year-old woman developed rhinoconjunctivitis and bronchial asthma related with the production of goat cheese, in a cheese factory. She was in charge of the cheese production process three days a week, and she had episodes of coughing, sneezing, rhinorrea, watery eyes, wheezing and dyspnoea, for 2 years. Symptoms decreased during the cheeses packing process and disappeared during holidays and weekends, suggesting an occupational exposure. She tolerated eating goat cheese. The patient had a normal...
Source: Occupational and Environmental Medicine - January 17, 2013 Category: Occupational Health Authors: Sastre, I., Rodriguez-Perez, R., Garcia, F., Juste, S., Moneo, I., Caballero, M. L. Tags: PostScript Source Type: research

Doctor Explains Why Flu a Greater Threat to Seniors
Weaker immune system, dehydration risks and less mobility all can make illness more dangerous
Source: Pulmonary Medicine News - Doctors Lounge - January 17, 2013 Category: Respiratory Medicine Authors: webmaster at doctorslounge.com Tags: Family Medicine, Geriatrics, Infections, Neurology, Nursing, Pediatrics, Pulmonology, Emergency Medicine, Immunology, Nutrition, News, Source Type: news

QUALITY CHOICE CHILDRENS ALLERGY RELIEF (Cetirizine Hydrochloride) Solution [Chain Drug Marketing Association]
Updated Date: Jan 17, 2013 EST
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - January 17, 2013 Category: Drugs & Pharmacology Source Type: news

nNOS participates in pemphigus vulgaris acantholysis through upregulation of Src, mTOR and FAK
Abstract Pemphigus vulgaris (PV) is an autoimmune blistering skin disease characterized by suprabasal acantholysis produced as a consequence of desmoglein (Dsg) and non‐Dsg autoantibodies binding to several targeting molecules localized on the membrane of keratinocytes. Nitric oxide (NO) may exert a pathogenic function in several immunologic processes. We have previously demonstrated that neural nitric oxide synthase (nNOS) plays part in PV acantholysis. Also, our group has described a relevant role for HER (human epidermal growth factor receptor related) isoforms and several kinases such as Src (Rous sarcoma), mammalian...
Source: Experimental Dermatology - January 17, 2013 Category: Dermatology Authors: Agustín España, Teresa Mòdol, Maria P Gil, Maria J López‐Zabalza Tags: Regular Article Source Type: research

Dendritic cells phenotype fitting under hypoxia or LPS. ABC transporters far beyond an efflux pump.
This study examines ABC‐transporters as a potential therapeutic target in dendritic cell (DC) modulation under hypoxia and LPS. Functional capacity of DCs (mixed lymphocyte reaction, MLR) and maturation of iDCs were evaluated in the presence or absence of specific ABC‐transporter inhibitors. Monocytes‐derived DCs were cultured in the presence of IL‐4/GM‐CSF. Their maturation under hypoxia or LPS conditions was evaluated by assessing the expression of maturation phenotypes using flow cytometry. The effect of ABC transporters on DC maturation was determined using specific inhibitors for MDR1 and MRPs. The functiona...
Source: Clinical and Experimental Immunology - January 17, 2013 Category: Allergy & Immunology Authors: N Lloberas, I Rama, I Llaudó, J Torras, G Cerezo, L Cassis, M Franquesa, A Merino, D Benitez, JM Cruzado, I Herrero‐Fresneda, O Bestard, JM Grinyó Tags: Original Article Source Type: research

Expression of CXCR3 and its ligands CXCL9, ‐10, ‐11 in pediatric OMS
Abstract Opsoclonus‐myoclonus syndrome (OMS) is a neuroinflammatory disorder associated with remote cancer. To better understand the role of inflammatory mediators, the concentration of CXCR3 ligands CXCL10, CXCL9, and CXCL11 was measured in 246 children with OMS and 81 pediatric controls using ELISA, and CXCR3 expression on CD4+ T cells was measured by flow cytometry. Mean cerebrospinal fluid (CSF) CXCL10 was 1.7‐fold higher in untreated OMS than controls. Intrathecal production was demonstrated by significantly different CXCL10 CSF:serum ratios. The dichotomized ‘high’ CSF CXCL10 group had higher CSF leukocyte co...
Source: Clinical and Experimental Immunology - January 17, 2013 Category: Allergy & Immunology Authors: Michael R. Pranzatelli, Elizabeth D. Tate, Nathan R. McGee, Anna L. Travelstead, Steven J. Verhulst, Richard M. Ransohoff Tags: Original Article Source Type: research

The efficacy of thymosin alpha 1 for severe sepsis (ETASS): a multicenter, single-blind, randomized and controlled trial
Conclusions: The use of Talpha1 therapy in combination with conventional medical therapies may be effective in improving clinical outcomes in a targeted population of severe sepsis.Trial registration: ClinicalTrials.gov NCT00711620.
Source: Critical Care - January 17, 2013 Category: Intensive Care Authors: Jianfeng WuLixin ZhouJiyun LiuGang MaQiuye KouZhijie HeJuan ChenBin Ou-YangMinying ChenYinan LiXiaoqin WuBaochun GuLei ChenZijun ZouXinhua QiangYuanyuan ChenAihua LinGuanrong ZhangXiangdong Guan Source Type: research

Specific and sensitive detection of Alcaligenes species from an agricultural environment
Abstract We developed a quantitative real‐time PCR assay to specificity detect and quantify the genus Alcaligenes in samples from the agricultural environment, such as vegetables and farming soils. The minimum detection sensitivity was 106 fg of pure culture DNA, corresponding to DNA extracted from two cells of A. faecalis. To evaluate the detection limit of A. faecalis, serially diluted genomic DNA from A. faecalis was mixed with DNA extracted from soil and vegetables, and then a standard curve was constructed. These results indicated that Alcaligenes species are present in the plant phytosphere at levels 102–104 time...
Source: Microbiology and Immunology - January 17, 2013 Category: Microbiology Authors: Miyo Nakano, Masumi Niwa, Norihiro Nishimura Tags: Note Source Type: research

Validation of Seattle Heart Failure Model for mortality risk prediction in patients treated with cardiac resynchronization therapy
Conclusions SHFM performance was found to be modest, tending to overestimate survival. However, SHFM identified a high-risk, globally more compromised patient subgroup, hence supporting a comprehensive approach, which should include nutritional, metabolic, and immunological aspects, as well as defibrillator back-up.
Source: European Journal of Heart Failure - January 17, 2013 Category: Cardiology Authors: Regoli, F., Scopigni, F., Leyva, F., Landolina, M., Ghio, S., Tritto, M., Calo, L., Klersy, C., Auricchio, A., for the collaborative study group Tags: CRT Source Type: research

Flublok, a Flu Vaccine, Wins F.D.A. Approval
The vaccine, called Flublok, can be ready more quickly in the event of a pandemic and, unlike current vaccines, will be an option for those allergic to eggs.
Source: NYT Health - January 16, 2013 Category: Consumer Health News Authors: By ANDREW POLLACK Tags: Flublok Food and Drug Administration Influenza Vaccination and Immunization Shortages Source Type: news

Angiotensin II Drives the Production of Tumor-Promoting Macrophages
Virna Cortez-Retamozo, Martin Etzrodt, Andita Newton, Russell Ryan, Ferdinando Pucci, Selena W. Sio, Wilson Kuswanto, Philipp J. Rauch, Aleksey Chudnovskiy, Yoshiko Iwamoto, Rainer Kohler, Brett Marinelli, Rostic Gorbatov, Gregory Wojtkiewicz, Peter Panizzi, Mari Mino-Kenudson, Reza Forghani, Jose-Luiz Figueiredo, John W. Chen, Ramnik Xavier, Filip K. Swirski, Matthias Nahrendorf, Ralph Weissleder, Mikael J. Pittet. Macrophages frequently infiltrate tumors and can enhance cancer growth, yet the origins of the macrophage response are not well understood. Here we address molecular mechanisms of macrophage produ....
Source: Immunity - January 16, 2013 Category: Allergy & Immunology Source Type: research

Amphiregulin Enhances Regulatory T Cell-Suppressive Function via the Epidermal Growth Factor Receptor
Dietmar M.W. Zaiss, Jorg van Loosdregt, Andrea Gorlani, Cornelis P.J. Bekker, Andrea Gröne, Maria Sibilia, Paul M.P. van Bergen en Henegouwen, Rob C. Roovers, Paul J. Coffer, Alice J.A.M. Sijts. Epidermal growth factor receptor (EGFR) is known to be critically involved in tissue development and homeostasis as well as in the pathogenesis of cancer. Here we showed that Foxp3+ reg....
Source: Immunity - January 16, 2013 Category: Allergy & Immunology Source Type: research

Immunology research sheds new light on cell function, response
Researchers characterized a new protein that affects how cells in the innate immune system function and protect humans against invading bacteria such as E. coli O157:H7.
Source: ScienceDaily Headlines - January 16, 2013 Category: Science Source Type: news

Fast food diet linked to asthma and eczema severity in kids, large study finds
Eating three or more weekly servings of fast food is linked to the severity of allergic asthma, eczema, and rhinitis among children in the developed world, indicates a large international study.
Source: ScienceDaily Headlines - January 16, 2013 Category: Science Source Type: news

Low Birth Weight Not Associated With Asthma Risk
Asthma is a serious condition that affects more than 25.7 million Americans, and is responsible for nearly 4,000 deaths annually. While the cause of asthma remains unknown, a study in the January issue of Annals of Allergy, Asthma and Immunology, the scientific journal of the American College of Allergy, Asthma and Immunology (ACAAI), has concluded that low birth weight is not associated with asthma risk in young children. "Asthma is the most common chronic illness in childhood and is a leading reason for missed school days," said allergist Hyeon Yang, M.D., lead study author...
Source: Health News from Medical News Today - January 16, 2013 Category: Consumer Health News Tags: Respiratory / Asthma Source Type: news

Human cytomegalovirus particles directly suppress CD4 T-lymphocyte activation and proliferation.
In this study, we found that HCMV directly inhibited proliferation of CD4 T cells and rendered them unresponsive to immunological stimuli. This effect was not observed when CD4 T cells were treated with herpes simplex virus-1/2 or measles virus. When stimulated with phytohemagglutinin, concanavalin A, or phorbol myristate acetate, HCMV-treated T cells were unable to proliferate, revealing an ability of HCMV to inhibit CD4 T cell response. Furthermore, HCMV also prevented proliferation of leukemic T-cell lines. HCMV-treated CD4 T cells expressed the activation markers CD45RO and CD69, were not apoptotic and produced decreas...
Source: Immunobiology - January 16, 2013 Category: Allergy & Immunology Authors: Fornara O, Odeberg J, Khan Z, Stragliotto G, Peredo I, Butler L, Söderberg-Nauclér C Tags: Immunobiology Source Type: research

Gastroesophageal Reflux Disease in Neonates and Infants : When and How to Treat.
Abstract Gastroesophageal reflux (GER) is defined as the involuntary retrograde passage of gastric contents into the esophagus with or without regurgitation or vomiting. It is a frequently experienced physiologic condition occurring several times a day, mostly postprandial and causes no symptoms. These infants are also called 'happy spitters'. GER disease (GERD) occurs when reflux of the gastric contents causes symptoms that affect the quality of life or pathologic complications, such as failure to thrive, feeding or sleeping problems, chronic respiratory disorders, esophagitis, hematemesis, apnea, and apparent lif...
Source: Paediatric Drugs - January 16, 2013 Category: Pediatrics Authors: Czinn SJ, Blanchard S Tags: Paediatr Drugs Source Type: research

The autoimmune-predisposing variant of lymphoid tyrosine phosphatase favors T helper 1 responses.
Abstract The C1858T single nucleotide polymorphism in PTPN22, which is the gene encoding lymphoid tyrosine phosphatase (LYP), confers increased risk for various autoimmune disorders in Caucasians. Although the disease-associated LYP allele (LYP∗W620) is a gain-of-function variant that has higher catalytic activity than the major allele (LYP∗R620), it is still unclear how LYP∗W620 predisposes for autoimmunity. Here, we compared both T cell signaling and T cell function in healthy human donors homozygous for either LYP∗R620 or LYP∗W620. Generally, the presence of LYP∗W620 caused reduced proximal T cell an...
Source: Human Immunology - January 16, 2013 Category: Allergy & Immunology Authors: Vang T, Landskron J, Viken MK, Oberprieler N, Torgersen KM, Mustelin T, Tasken K, Tautz L, Rickert RC, Lie BA Tags: Hum Immunol Source Type: research