Allergy & Immunology 
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This page shows you the most recent publications within this specialty of the MedWorm directory.
111285 records returned
Postoperative Pain Trajectories in Cardiac Surgery Patients
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Poorly controlled postoperative pain is a longstanding and costly problem in medicine. The purposes of this study were to characterize the acute pain trajectories over the first four postoperative days in 83 cardiac surgery patients with a mixed effects model of linear growth to determine whether statistically significant individual differences exist in these pain trajectories, and to compare the quality of measurement by trajectory with conventional pain measurement practices. The data conformed to a linear model that provided slope (rate of change) as a basis for comparing patients. Slopes varied significantly across pat...
Source: Clinical and Developmental Immunology - February 8, 2012 Category: Allergy & Immunology Source Type: research
Physician Wages in States with Expanded APRN Scope of PracticeEmail this article to a colleague.
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In recent years, states have looked to reforms in advanced practice nursing scope of practice (SOP) barriers as a potential means to increase access to primary care while reducing costs. Currently, 16 states and the District of Columbia permit advanced practice registered nurses to practice independently of physicians, allowing them to perform functions such as diagnosing and prescribing under their own authority within the primary care setting. Given the resistance of many physician associations to these reforms, we asked whether the economic interests of primary care physicians might be affected by reforms. Using the Bur...
Source: Clinical and Developmental Immunology - February 8, 2012 Category: Allergy & Immunology Source Type: research
Solving the Short-Term Scheduling Problem of Hydrothermal Systems via Lagrangian Relaxation and Augmented LagrangianEmail this article to a colleague.
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The objective consists in minimizing the operation cost over a two-day horizon with a one-hour time resolution. To solve this difficult problem, a Lagrangian Relaxation (LR) based on variable splitting is designed where the resulting dual problem is solved by a Bundle method. Given that the LR usually fails to find a feasible solution, we use an inexact Augmented Lagrangian method to improve the quality of the solution supplied by the LR. We assess our approach by using a real-life hydrothermal configuration extracted from the Brazilian power system, proving the conceptual and practical feasibility of the proposed algorith...
Source: Clinical and Developmental Immunology - February 8, 2012 Category: Allergy & Immunology Source Type: research
Effects of Thermocapillarity and Thermal Radiation on Flow and Heat Transfer in a Thin Liquid Film on an Unsteady Stretching SheetEmail this article to a colleague.
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This paper examines the effects of thermocapillarity and thermal radiation on the boundary layer flow and heat transfer in a thin film on an unsteady stretching sheet with nonuniform heat source/sink. The governing
partial differential equations are converted into ordinary differential equations by a similarity transformation and then are solved by using the homotopy analysis method (HAM). The effects of the radiation parameter, the
thermocapillarity number, and the temperature-dependent parameter in this
study are discussed and presented graphically via velocity and temperature
profiles. (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - February 8, 2012 Category: Allergy & Immunology Source Type: research
Magnetostrictive Actuation of a Bone Loading Composite for Accelerated Tissue FormationEmail this article to a colleague.
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When bone is dynamically loaded it adapts its shape to better support the load. We have developed a magnetostrictive composite consisting of Terfenol-D particles encapsulated in an epoxy resin that changes length when exposed to magnetic fields. When bonded to the surface of a porcine tibia ex vitro, the composite produces surface strains greater than 900 με at a frequency of 30 Hz and magnetic field of 170 kA/m. This is more than sufficient strain magnitude and frequency to promote cortical bone growth in both rats and turkeys and to maintain cortical bone structure in humans. Key advantag...
Source: Clinical and Developmental Immunology - February 8, 2012 Category: Allergy & Immunology Source Type: research
Radiation Analysis for Two Trajectory Points of the Fire II EntryEmail this article to a colleague.
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Numerical rebuilding of two trajectory points (t=1634 s and t=1643 s) of the Fire II mission has been carried out to predict the radiative heat flux for nonequilibrium and close-to-equilibrium conditions. The simulations have been performed with eilmer3 in an uncoupled way and using a tangent slab method for the radiation transport. Different population models
(QSS and Boltzmann) have been compared, and the influence of catalytic wall condition was taken into account. An analysis on the spectral range and on the spectral resolution has also been carried out. (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - February 8, 2012 Category: Allergy & Immunology Source Type: research
Pulmonary Bacterial Communities in Surgically Resected Noncystic Fibrosis Bronchiectasis Lungs Are Similar to Those in Cystic FibrosisEmail this article to a colleague.
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Conclusions. Our data indicate significant diversity in the pulmonary bacterial community of both CF and non-CF bronchiectasis patients and suggest that this community is similar in surgically resected lungs of CF and non-CF bronchiectasis patients. (Source: Clinical and Developmental Immunology)
Source: Clinical and Developmental Immunology - February 8, 2012 Category: Allergy & Immunology Source Type: research
Improvement of Amperometric Biosensor Performance for H2O2 Detection based on Bimetallic PtM (M = Ru, Au, and Ir) NanoparticlesEmail this article to a colleague.
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Novel bimetallic nanoparticles have been synthesized via rapid microwave irradiation, leading to an improved sensitivity and
a highly anti-interference property for amperometric biosensor in H2O2 detection. The material characterizations
were performed by TEM, XRD, and EDX, which show the bimetallic formation of Pt-based catalysts and well-dispersed nanoparticles of
2–5 nm. The sensitivities for the detection of H2O2 of PtRu, PtAu, and PtIr as the biosensor working electrode catalysts are 539.01 (R2=0.99), 415.46 (R2=0.99), and 404.52 (R2=0.97) μA⋅mM−1Ȭ...
Source: Clinical and Developmental Immunology - February 8, 2012 Category: Allergy & Immunology Source Type: research
Leptin in Anorexia and Cachexia SyndromeEmail this article to a colleague.
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Leptin is a product of the obese (OB) gene secreted by adipocytes in proportion to fat mass. It decreases food intake and increases energy expenditure by affecting the balance between orexigenic and anorexigenic hypothalamic pathways. Low leptin levels are responsible for the compensatory increase in appetite and body weight and decreased energy expenditure (EE) following caloric deprivation. The anorexia-cachexia syndrome is a complication of many chronic conditions including cancer, chronic obstructive pulmonary disease, congestive heart failure, chronic kidney disease, and aging, where the decrease in body weight and fo...
Source: Clinical and Developmental Immunology - February 8, 2012 Category: Allergy & Immunology Source Type: research
Aqueous Synthesis of CdTe Quantum Dot Using Dithiol-Functionalized Ionic LiquidEmail this article to a colleague.
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We report on an aqueous synthesis of cadmium telluride (CdTe) nanocrystals by using dithiol-functionalized ionic liquids (dTFILs). The dTFILs were designed to have dithiol and vinylimidazolium functional groups and used as a ligand molecule of CdTe quantum dot (QD) to utilize the bidendate chelate interaction afforded by the dithiol groups of dTFILs. The photoluminescence quantum yield of dTFIL-capped CdTe QDs reached up to ~40%, and their luminescent property was maintained for 8 weeks, suggesting an improved stability in water phase. This approach will provide a new synthetic route to the water soluble QDs. (Source: ...
Source: Clinical and Developmental Immunology - February 8, 2012 Category: Allergy & Immunology Source Type: research
Fluorescence Properties and Synthesis of Green-Emitting Tb3+-Activated Amorphous Calcium Silicate Phosphor by Ultraviolet Irradiation of 378 nmEmail this article to a colleague.
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This study describes novel green-emitting Tb3+-activated amorphous calcium silicate by ultraviolet excitation at 378 nm. The Tb3+-activated amorphous calcium silicate was prepared by heating a sample of Tb3+-activated calcium silicate hydrate (CSH) at 900°C for 30 minutes. The emission wavelength of the resulting phosphor was 544 nm. The optimum excitation wavelength within the range 300–400 nm was 378 nm. The Tb3+-activated amorphous calcium silicate emitted green by ultraviolet irradiation. The optimum initial Tb/Ca atomic ratio of this phosphor was about 0.5. A mechanism for the action of...
Source: Clinical and Developmental Immunology - February 8, 2012 Category: Allergy & Immunology Source Type: research
DNA Damage Protecting Activity and Free Radical Scavenging Activity of Anthocyanins from Red Sorghum (Sorghum bicolor) BranEmail this article to a colleague.
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There is increasing interest in natural food colorants like carotenoids and anthocyanins with functional properties. Red sorghum bran is known as a rich source for anthocyanins. The anthocyanin contents extracted from red sorghum bran were evaluated by biochemical analysis. Among the three solvent system used, the acidified methanol extract showed a highest anthocyanin content (4.7 mg/g of sorghum bran) followed by methanol (1.95 mg/g) and acetone (1 mg/g). Similarly, the highest total flavonoids (143 mg/g) and total phenolic contents (0.93 mg/g) were obtained in acidified methanol extrac...
Source: Clinical and Developmental Immunology - February 8, 2012 Category: Allergy & Immunology Source Type: research
Electrospun Nanostructured Fibers of Collagen-Biomimetic Apatite on Titanium AlloyEmail this article to a colleague.
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Titanium and its alloys are currently the mainly used materials to manufacture orthopaedic implants due to their excellent mechanical properties and corrosion resistance. Although these materials are bioinert, the improvement of biological properties (e.g., bone implant contact) can be obtained by the application of a material that mimics the bone extracellular matrix. To this aim, this work describes a new method to produce nanostructured collagen-apatite composites on titanium alloy substrate, by combining electrospinning and biomimetic mineralization. The characterization results showed that the obtained mineralized sca...
Source: Clinical and Developmental Immunology - February 8, 2012 Category: Allergy & Immunology Source Type: research
Effects of High-Mobility Group A Protein Application on Canine Adipose-Derived Mesenchymal Stem Cells In VitroEmail this article to a colleague.
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Multipotency and self-renewal are considered as most important features of stem cells to persist throughout life in tissues. In this context, the role of HMGA proteins to influence proliferation of adipose-derived mesenchymal stem cell (ASCs) while maintaining their multipotent and self-renewal capacities has not yet been investigated. Therefore, extracellular HMGA1 and HMGA2 application alone (10–200 ng/mL) and in combination with each other (100, 200 ng/mL each) was investigated with regard to proliferative effects on canine ASCs (cASCs) after 48 hours of cultivation. Furthermore, mRNA expression of m...
Source: Clinical and Developmental Immunology - February 8, 2012 Category: Allergy & Immunology Source Type: research
Kappa-Opioid Receptors in the Caudal Nucleus Tractus Solitarius Mediate 100 Hz Electroacupuncture-Induced Sleep Activities in RatsEmail this article to a colleague.
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Previous results demonstrated that 10 Hz electroacupuncture (EA) of Anmian acupoints in rats during the dark period enhances slow wave sleep (SWS), which involves the induction of cholinergic activity in the caudal nucleus tractus solitarius (NTS) and subsequent activation of opioidergic neurons and μ-receptors. Studies have shown that different kinds of endogenous opiate peptides and receptors may mediate the consequences of EA with different frequencies. Herein, we further elucidated that high-frequency (100 Hz)-EA of Anmian enhanced SWS during the dark period but exhibited no direct effect on rapid eye mo...
Source: Clinical and Developmental Immunology - February 8, 2012 Category: Allergy & Immunology Source Type: research
Effective Silencing of Sry Gene with RNA Interference in Developing Mouse Embryos Resulted in Feminization of XY GonadEmail this article to a colleague.
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Delivering siRNA or shRNA into the developing embryos is still a main challenge to use of RNAi in mammalian systems. Here we analyze several factors influencing RNAi-mediated silencing of Sry gene, which is a tightly controlled spatiotemporal expressed gene and only shortly expressed in developing mouse embryo gonad. A Sry gene-specific shRNAs expression vector (pSilencer4.1/Sry565) was constructed. The shRNA constructs were mixed with polyethylenimines (PEIs) to form a complex and then injected into pregnant mice though tail vein. Our results showed that Sry gene was downregulated significantly in developing embryos. Furt...
Source: Clinical and Developmental Immunology - February 8, 2012 Category: Allergy & Immunology Source Type: research
Pseudomonas sp. as a Source of Medium Chain Length Polyhydroxyalkanoates for Controlled Drug Delivery: PerspectiveEmail this article to a colleague.
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Controlled drug delivery technology represents one of the most rapidly advancing areas of science. They offer numerous advantages compared to conventional dosage forms including improved efficacy, reduced toxicity, improved patient compliance and convenience. Over the past several decades, many delivery tools or methods were developed such as viral vector, liposome-based delivery system, polymer-based delivery system, and intelligent delivery system. Recently, nonviral vectors, especially those based on biodegradable polymers, have been widely investigated as vectors. Unlike the other polymers tested, polyhydroxyalkanoates...
Source: Clinical and Developmental Immunology - February 8, 2012 Category: Allergy & Immunology Source Type: research
Production of Oxidants by Ion Bombardment of Icy Moons in the Outer Solar SystemEmail this article to a colleague.
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Our groups in Brazil, France and Italy have been active, among others in the world, in performing experiments on physical-chemical effects induced by fast ions colliding with solids (frozen gases, carbonaceous and organic materials, silicates, etc.) of astrophysical interest. The used ions span a very large range of energies, from a few keV to hundreds MeV. Here we present a summary of the results obtained so far on the formation of oxidants (hydrogen peroxide and ozone) after ion irradiation of frozen water, carbon dioxide and their mixtures. Irradiation of pure water ice produces hydrogen peroxide whatever is the used io...
Source: Clinical and Developmental Immunology - February 8, 2012 Category: Allergy & Immunology Source Type: research
Synthesis and Characterization of New Lead(II) and Organotin(IV) Complexes of Schiff Bases Derived from Histidine and MethionineEmail this article to a colleague.
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New Schiff base (HL) ligand is prepared via condensation of isatins and amino acids in 1:1 molar ratio. Metal complexes are prepared and characterized by elemental analysis, molar conductance, electronic, infrared, and multinuclear magnetic resonance (1H NMR, 13C NMR, and 119Sn NMR). The analytical data showed that the ligand acts as bidentate toward metal ions via azomethine nitrogen and carboxylate oxygen by a stoichiometric reaction of metal : ligand (1 : 2) to from metal complexes (Pb(II)(L)2 and Bu2Sn(L)2, where L is the Schiff base ligands of histidine and methionine). The conductivity val...
Source: Clinical and Developmental Immunology - February 8, 2012 Category: Allergy & Immunology Source Type: research
Nonparametric Confidence Limits of Quantile-Based Process Capability IndicesEmail this article to a colleague.
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We propose an asymptotic nonparametric confidence interval for quantile-based process capability indices (PCIs) based on the superstructure CNp(u,v) modified from Cp(u,v) which contains the four basic PCIs, Cp, Cpk, Cpm, and Cpmk, as special cases. Since the asymptotic variance of the estimator for quantile-based PCIs involves the density function of the underlying process, the existing asymptotic results cannot be used directly to construct confidence limits for PCIs. To obtain a consistent estimator for the asymptotic variance of the estimated quantile-based PCIs, in this paper, we propose to use the kernel density estim...
Source: Clinical and Developmental Immunology - February 8, 2012 Category: Allergy & Immunology Source Type: research
MOfinder: A Novel Algorithm for Detecting Overlapping Modules from Protein-Protein Interaction NetworkEmail this article to a colleague.
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In this study, a new method, MOfinder, was developed to detect overlapping modules in a protein-protein interaction (PPI) network. We demonstrate that our method is more accurate than other 5 methods. Then, we applied MOfinder to yeast and human PPI network and explored the overlapping information. Using the overlapping modules of human PPI network, we constructed the module-module communication network. Functional annotation showed that the immune-related and cancer-related proteins were always together and present in the same modules, which offer some clues for immune therapy for cancer. Our study around overlapping modu...
Source: Clinical and Developmental Immunology - February 8, 2012 Category: Allergy & Immunology Source Type: research
Detection of Chromosome X;18 Breakpoints and Translocation of the Xq22.3;18q23 Regions Resulting in Variable Fertility PhenotypesEmail this article to a colleague.
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We describe a familial pattern of gonosomal-autosomal translocation between the X and 18 chromosomes, balanced and unbalanced forms, in male and female siblings. The proposita was consulted for hypergonadotropic hypogonadism. Karyotype analysis revealed a balanced 46, X, t(X;18)(q22.3;q23) genotype. The sister of the proband presented with oligomenorrhea with irregular menses and possesses an unbalanced form of the translocation 46, X, der(X), t(X;18)(q22.3;q23). The brother of the proband was investigated and was found to possess the balanced form of the same translocation, resulting in disrupted spermatogenesis. Maternal...
Source: Clinical and Developmental Immunology - February 8, 2012 Category: Allergy & Immunology Source Type: research
RetractionEmail this article to a colleague.
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(Source: Tissue Antigens)
Source: Tissue Antigens - February 8, 2012 Category: Allergy & Immunology Source Type: research
Nomenclature for factors of the HLA system, update December 2011Email this article to a colleague.
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(Source: Tissue Antigens)
Source: Tissue Antigens - February 8, 2012 Category: Allergy & Immunology Authors: Steven G. E. Marsh Source Type: research
Nomenclature for factors of the HLA system, update November 2011Email this article to a colleague.
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(Source: Tissue Antigens)
Source: Tissue Antigens - February 8, 2012 Category: Allergy & Immunology Authors: Steven G. E. Marsh Source Type: research
Nomenclature for factors of the HLA system, update October 2011Email this article to a colleague.
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(Source: Tissue Antigens)
Source: Tissue Antigens - February 8, 2012 Category: Allergy & Immunology Authors: Steven G. E. Marsh Source Type: research
Sequence evolution and escape from specific immune pressure of an HIV‐1 Rev epitope with extensive sequence similarity to human nucleolar protein 6Email this article to a colleague.
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This study shows that the HLA‐B44‐restricted Rev CD8+ T‐cell epitope EL9 is immunogenic notwithstanding its close resemblance to a human peptide. The epitope mutates as a consequence of dynamic interaction between T‐cells and HIV‐1. Clinical status, CD4+ T‐cell count and viral load remained stable despite escape from T‐cell recognition. (Source: Tissue Antigens)
Source: Tissue Antigens - February 8, 2012 Category: Allergy & Immunology Authors: S. D. AllardA. L. de GoedeB. De KeersmaeckerC. HeirmanP. LacorA. D. M. E. OsterhausC. DemanetK. ThielemansR. A. GrutersJ. L. Aerts Source Type: research
Analysis of HLA‐DM polymorphisms in the Chinese Han populationEmail this article to a colleague.
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This study lays the foundations for further disease association analyses. (Source: Tissue Antigens)
Source: Tissue Antigens - February 8, 2012 Category: Allergy & Immunology Authors: M. L. FengR. Z. LiuT. ShenY. L. ZhaoZ. Y. ZhuD. Z. Liu Source Type: research
Targeting HLA class I expression to increase tumor immunogenicityEmail this article to a colleague.
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The dynamic interaction between the host immune system and growing cancer has been of central interest to the field of tumor immunology over the past years. Recognition of tumor‐associated antigens (TAA) by self‐HLA (human leukocyte antigen) class I‐restricted CD8+ T cells is a main feature in the detection and destruction of malignant cells. The discovery and molecular characterization of TAA has changed the field of cancer treatment and introduced a new era of cancer immunotherapy aimed at increasing tumor immunogenicity and T‐cell‐mediated anti‐tumor immunity. Unfortunately, while these new protocols of canc...
Source: Tissue Antigens - February 8, 2012 Category: Allergy & Immunology Authors: A. B. del CampoJ. CarreteroN. AptsiauriF. Garrido Source Type: research
Soda Linked to Lung Disease (CME/CE)Email this article to a colleague.
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(MedPage Today) -- More bad news for soda lovers: in addition to obesity and heart disease, the sugary drinks may be tied to asthma and chronic obstructive pulmonary disease (COPD), Australian researchers found. (Source: MedPage Today Allergy)
Source: MedPage Today Allergy - February 8, 2012 Category: Allergy & Immunology Source Type: news
Factors associated with a shorter time until the next pulmonary exacerbation in adult patients with cystic fibrosis.Email this article to a colleague.
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Abstract
Time until the subsequent exacerbation (PEx) in cystic fibrosis (CF) is a significant health outcome and one of the significant end points in clinical trials. Risk factors associated with shorter time until the next exacerbation (TUNE) have not been reported. This is a prospective study. TUNE was the number of days from the end of intravenous (IV) antibiotic treatment of a PEx until the day of start of IV antibiotics for the following PEx. Factors assessed were age, gender, site of treatment, CF-related diabetes (CFRD), allergic bronchopulmonary aspergillosis (ABPA) and infection with Pseudomonas aeruginos...
Source: Chronic Respiratory Disease - February 8, 2012 Category: Respiratory Medicine Authors: Sequeiros IM, Jarad N Tags: Chron Respir Dis Source Type: research
Acupuncture compared with oral antihistamine for type I hypersensitivity itch and skin response in adults with atopic dermatitis – a patient‐ and examiner‐blinded, randomized, placebo‐controlled, crossover trialEmail this article to a colleague.
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ConclusionsBoth VA and cetirizine significantly reduced type I hypersensitivity itch in patients with AD, compared with both placebo and NI. Timing of acupuncture application was important, as VAa had the most significant effect on itch, potentially because of counter‐irritation and/or distraction. Itch reduction following cetirizine coincided with reduced attention. (Source: Allergy)
Source: Allergy - February 8, 2012 Category: Allergy & Immunology Authors: F. PfabM.‐T. KirchnerJ. Huss‐MarpT. SchusterP. C. SchalockJ. FuqinG. I. AthanasiadisH. BehrendtJ. RingU. DarsowV. Napadow Tags: Original Article Source Type: research
Luminal decoration of blood vessels by activated perivasal mast cells in allergic rhinitisEmail this article to a colleague.
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ConclusionDirect membrane transfer from perivasal mast cells into nearby blood vessels constitutes a novel mechanism to modulate endothelial surface features with apparent significance in allergic diseases. (Source: Allergy)
Source: Allergy - February 8, 2012 Category: Allergy & Immunology Authors: T. SchaeferA. ZajonzP. LorentzT. BohnackerM. P. WymannT. Schweighoffer Tags: Original Article Source Type: research
ErratumEmail this article to a colleague.
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Neuroimmunomodulation 2012;19:157 (DOI:10.1159/000336928) (Source: Neuroimmunomodulation)
Source: Neuroimmunomodulation - February 7, 2012 Category: Allergy & Immunology Source Type: research
News From The Journal Of Clinical Investigation: Feb. 6, 2012Email this article to a colleague.
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IMMUNOLOGY: How a stomach-colonizing bacterium protects against asthma The bacterium Helicobacter pylori can be found colonizing the stomach lining of almost half the world's population. Although persistent infection with Helicobacter pylori increases an individual's risk of developing stomach cancer, it also decreases their risk of developing asthma. A team of researchers led by Anne Muller, at the University of Zürich, Switzerland, has now identified a cellular mechanism by which persistent infection with Helicobacter pylori protects mice from developing allergic asthma... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 7, 2012 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news
Key To Immune Cell's 'internal Guidance' System DiscoveredEmail this article to a colleague.
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University of British Columbia researchers have discovered the molecular pathway that enables receptors inside immune cells to find, and flag, fragments of pathogens trying to invade a host. The discovery of the role played by the molecule CD74 could help immunologists investigate treatments that offer better immune responses against cancers, viruses and bacteria, and lead to more efficient vaccines. The findings are published in this week's edition of Nature Immunology... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 7, 2012 Category: Consumer Health News Tags: Immune System / Vaccines Source Type: news
Natural vanadium-containing jeju groundwater inhibits immunoglobulin e-mediated anaphylactic reaction and suppresses eicosanoid generation and degranulation in bone marrow derived-mast cells.Email this article to a colleague.
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Abstract
The high-affinity receptor for immunoglobulin E (IgE) (FcεRI)-mediated activation of mast cells plays an important role in various allergic diseases. To assess the anti-allergic activity of natural vanadium-containing Jeju groundwater (JW), an in vivo passive cutaneous anaphylaxis (PCA) animal model and in vitro mouse bone marrow-derived mast cells (BMMCs) was used. JW inhibited cyclooxygenase-2 (COX-2)-dependent prostaglandin D(2) (PGD(2)) generation in a dose-dependent manner, with a concomitant reduction of COX-2 protein expression in IgE-induced BMMCs. In addition, JW inhibited 5-lipoxygenase (5-LOX)-...
Source: Biological and Pharmaceutical Bulletin - February 6, 2012 Category: Drugs & Pharmacology Authors: Li X, Lu Y, Yang JH, Jin Y, Hwang SL, Chang HW Tags: Biol Pharm Bull Source Type: research
Acknowledgment of ReviewersEmail this article to a colleague.
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Viral Immunology Feb 2012, Vol. 25, No. 1: 91-95. (Source: Viral Immunology)
Source: Viral Immunology - February 6, 2012 Category: Allergy & Immunology Tags: article Source Type: research
Unraveling the mystery of the hygiene hypothesis through Helicobacter pylori infectionEmail this article to a colleague.
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Epidemiological studies have revealed an inverse association between Helicobacter pylori infection and the incidence of allergic asthma. This association is consistent with the hygiene hypothesis, which posits that exposure to microbes early in life prevents the later development of allergic diseases, and has been reproduced in mouse models of asthma. In this issue of the JCI, Oertli and colleagues report that H. pylori infection in neonates elicits tolerogenic DCs that produce IL-18, which drive the generation of Tregs that subsequently protect the mice from allergic asthma. This finding strengthens the intriguing link be...
Source: Journal of Clinical Investigation - February 6, 2012 Category: Biomedical Science Authors: Kouji Matsushima, Shigenori Nagai Source Type: research
DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori-specific immune tolerance, and asthma protectionEmail this article to a colleague.
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Persistent colonization with the gastric bacterial pathogen Helicobacter pylori causes gastritis and predisposes infected individuals to gastric cancer. Conversely, it is also linked to protection from allergic, chronic inflammatory, and autoimmune diseases. We demonstrate here that H. pylori inhibits LPS-induced maturation of DCs and reprograms DCs toward a tolerance-promoting phenotype. Our results showed that DCs exposed to H. pylori in vitro or in vivo failed to induce T cell effector functions. Instead, they efficiently induced expression of the forkhead transcription factor FoxP3, the master regulator of Tregs, in na...
Source: Journal of Clinical Investigation - February 6, 2012 Category: Biomedical Science Authors: Mathias Oertli, Malin Sundquist, Iris Hitzler, Daniela B. Engler, Isabelle C. Arnold, Sebastian Reuter, Joachim Maxeiner, Malin Hansson, Christian Taube, Marianne Quiding-Järbrink, Anne Müller Source Type: research
Dendritic Cells and Aging: Consequences for AutoimmunityDendritic Cells and Aging: Consequences for AutoimmunityEmail this article to a colleague.
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The immune system has evolved to mount immune responses against foreign pathogens and to remain silent against self-antigens. Expert Review of Clinical Immunology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 6, 2012 Category: Consumer Health News Tags: Allergy & Clinical Immunology Journal Article Source Type: news
Within Weeks Of Smoking Cessation, Coughing And Other Respiratory Symptoms ImproveEmail this article to a colleague.
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If the proven long-term benefits of smoking cessation are not enough to motivate young adults to stop smoking, a new study shows that 18- to 24-year olds who stop smoking for at least two weeks report substantially fewer respiratory symptoms, especially coughing. The study findings are detailed in Pediatric Allergy, Immunology, and Pulmonology, a peer-reviewed journal published by Mary Ann Liebert, Inc. The article is available online... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 6, 2012 Category: Consumer Health News Tags: Smoking / Quit Smoking Source Type: news
Sunshine May Help To Prevent Allergies And EczemaEmail this article to a colleague.
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Increased exposure to sunlight may reduce the risk of both food allergies and eczema in children, according to a new scientific study. Researchers from the European Centre for Environment & Human Health, along with several Australian institutions, have found that children living in areas with lower levels of sunlight are at greater risk of developing food allergies and the skin condition eczema, compared to those in areas with higher UV. The research team used data from a study of Australian children and analysed how rates of food allergy, eczema and asthma varied throughout the country... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 6, 2012 Category: Consumer Health News Tags: Allergy Source Type: news
Leishmania amazonensis impairs DC function by inhibiting CD40 expression via A2B adenosine receptor activationEmail this article to a colleague.
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In conclusion, we propose that A2B receptor activation may be used by L. amazonensis to inhibit DC function and evade the immune response. (Source: European Journal of Immunology)
Source: European Journal of Immunology - February 6, 2012 Category: Allergy & Immunology Authors: Amanda B. FigueiredoTiago D. SerafimEduardo A. Marques‐da‐SilvaJosé R. Meyer‐FernandesLuís C. C. Afonso Tags: Regular Article Source Type: research
Protein kinase D isoforms are dispensable for integrin‐mediated lymphocyte adhesion and homing to lymphoid tissuesEmail this article to a colleague.
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We report that PKD2‐deficient lymphocytes bound normally to integrin ligands in static and shear flow adhesion assays. They also homed normally to lymphoid organs after adoptive transfer into wild‐type mice. DT40 B cells devoid of any PKD isoforms and primary lymphocytes pretreated with a specific PKD inhibitor bound normally to integrin ligands, indicating that multiple PKD isoforms do not redundantly regulate lymphocyte integrins. In addition, PKD2‐deficient lymphocytes, as well as DT40 cells devoid of any PKD isoforms, could activate Rap1 in response to BCR ligation or phorbol ester treatment. Together, these resu...
Source: European Journal of Immunology - February 6, 2012 Category: Allergy & Immunology Authors: Sharon A. MatthewsHwee San LekVicky L. MorrisonMatthew G. MackenzieMarouan ZarroukDoreen CantrellSusanna C. Fagerholm Tags: Regular Article Source Type: research
Enhanced effects of cigarette smoke extract on inflammatory cytokine expression in IL-1beta-activated human mast cells were inhibited by Baicalein via regulation of the NF-kappaB pathwayEmail this article to a colleague.
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Conclusions: Our results showed that CSE significantly increased inflammatory cytokines IL-6 and IL-8 production in IL-1-activated HMC-1. It may partially explain why cigarette smoke contributes to lung and cardiovascular diseases. BAI inhibited the production of inflammatory cytokines through inhibition of NF-kappaB activation and IkappaBalpha phosphorylation and degradation. This inhibitory effect of BAI on the expression of inflammatory cytokines induced by CSE suggests its usefulness in the development of novel anti-inflammatory therapies. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - February 6, 2012 Category: Allergy & Immunology Authors: David ChiTa-Chang LinKenton HallTuanzhu HaChuanfu LiZong Doa WuThomas SoikeGuha Krishnaswamy Source Type: research
Clara cell protein in nasal lavage fluid and nasal nitric oxide - biomarkers with anti-inflammatory properties in allergic rhinitisEmail this article to a colleague.
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Conclusions:
The correlation between nasal CC16 and nNO levels in patients with allergic rhinitis, along with an inverse relationship between their levels and the occurrences of MC in allergic inflammation, may indicate that both biomarkers have anti-inflammatory effects by suppression of cell recruitment. The mechanisms behind these observations warrant further analyses. (Source: Clinical and Molecular Allergy)
Source: Clinical and Molecular Allergy - February 6, 2012 Category: Allergy & Immunology Authors: Kristina IranderJorgen PalmMagnus BorresBijar Ghafouri Source Type: research
Prenatal negative life events increases cord blood IgE: interactions with dust mite allergen and maternal atopyEmail this article to a colleague.
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ConclusionsPrenatal stress was independently associated with elevated cord blood IgE. Mechanisms underlying stress effects on fetal immunomodulation may differ based on maternal atopic status. (Source: Allergy)
Source: Allergy - February 6, 2012 Category: Allergy & Immunology Authors: J. L. PetersS. CohenJ. StaudenmayerJ. HosenT. A. E. Platts‐MillsR. J. Wright Tags: Original Article Source Type: research
Thermographic imaging during nasal peanut challenge may be useful in the diagnosis of peanut allergyEmail this article to a colleague.
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ConclusionThis feasibility study shows thermography can detect inflammation caused by nasal challenges whilst employing one thousand‐fold less peanut than an oral challenge. This novel technique could be developed to provide a rapid, safe and objective clinical allergy test. (Source: Allergy)
Source: Allergy - February 6, 2012 Category: Allergy & Immunology Authors: A. ClarkJ. MangatY. KingS. IslamK. AnagnostouL. FoleyJ. DeightonP. Ewan Tags: Brief Communication Source Type: research
One hundred years of allergen immunotherapy European Academy of Allergy and Clinical Immunology celebration: review of unanswered questionsEmail this article to a colleague.
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This study presents outcomes and conclusions from these discussions. (Source: Allergy)
Source: Allergy - February 6, 2012 Category: Allergy & Immunology Authors: M. CalderónV. CardonaP. Demoly Tags: Review Article Source Type: research
