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Lung Separation in the Morbidly Obese Patientemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Lung separation techniques in the morbidly obese patient undergoing thoracic or esophageal surgery may be at risk of complications during airway management. Access to the airway in the obese patient can be a challenge because they have altered airway anatomy, including a short and redundant neck, limited neck extension and accumulation of fat deposition in the pharyngeal wall contributing to difficult laryngoscopy. Securing the airway is the first priority in these patients followed by appropriate techniques for lung separation with the use of a single-lumen endotracheal tube and a bronchial blocker or another alternative ...
Source: Advances in Urology - February 6, 2012 Category: Urology & Nephrology Source Type: research

Spaghetti western reveals differences between human and monkey brainsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
A 'neurocinematic' comparison provides clues about evolution of the human brainMonkeys are closely related to us and their brains have long served as an indispensable model for understanding how our own brain works. But we're separated from each other by millions of years of evolution, so there are some major differences between their brains and ours. On the one hand, we can't assume that the results from experiments on their brains can be generalized to humans. But on the other, a better understanding of our differences can provide important clues about the evolutionary forces that shaped the human brain. A new method may...
Source: Guardian Unlimited Science - February 5, 2012 Category: Science Authors: Mo Costandi Tags: Neuroscience Evolution guardian.co.uk Blogposts Source Type: news

Brassinosteroid regulates stomatal development by GSK3-mediated inhibition of a MAPK pathwayemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
-Yong Wang Plants must coordinate the regulation of biochemistry and anatomy to optimize photosynthesis and water-use efficiency. The formation of stomata, epidermal pores that facilitate gas exchange, is highly coordinated with other aspects of photosynthetic development. The signalling pathways controlling stomata development are not fully understood, although mitogen-activated protein kinase (MAPK) signalling is known to have key roles. Here we demonstrate in Arabidopsis that brassinosteroid regulates stomatal development by activating the MAPK kinase kinase (MAPKKK) YDA (also known as YODA). Genetic analyses indicate t...
Source: Nature AOP - February 5, 2012 Category: Research Authors: Tae-Wuk KimMarta MichniewiczDominique C. BergmannZhi-Yong Wang Tags: Letter Source Type: research

Colon Anatomy (Cross Section)email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The colon is about six feet long and is the part of the body's digestive system that moves waste material from the small intestine to the rectum. The colon is comprised of four distinct layers: the mucosa, the submucosa, the muscularis externa (two thick bands of muscle), and the serosa. Learn more about each in this colon anatomy gallery. (Source: About.com Colon Cancer)
Source: About.com Colon Cancer - February 5, 2012 Category: Cancer & Oncology Authors: coloncancer.guide at about.com Tags: health Source Type: news

Jacqueline Rose: a life in writingemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
'Victimhood is something that happens but when you turn it into an identity you're psychically and politically finished'One day, Jacqueline Rose came across a troubling passage in Proust's A la recherche du temps perdu. The narrator, Marcel, lies beside his sleeping lover Albertine and masturbates against her. "It seemed to me at those moments," writes Proust in Carol Clark's recent Penguin translation, "that I possessed her more completely, like an unconscious part of dumb nature." Professor Rose, feminist and psychoanalytic critic, bristled. "I thought 'This is ridiculous – she'd have woken up by now!' I had my feminis...
Source: Guardian Unlimited Science - February 3, 2012 Category: Science Authors: Stuart Jeffries Tags: Books Culture Fiction History Marcel Proust Feminism Psychology Israel Poetry Sylvia Plath Ted Hughes The Guardian Features Source Type: news

[ST NetWatch] EMAP: The e-Mouse Atlas Projectemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Explore mouse anatomy and spatial patterns of gene expression. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - February 3, 2012 Category: Science Authors: Nancy Gough (mailto:ngough at aaas.org) Source Type: news

MDCT of abdominal wall lumbar hernias: anatomical review, pathologic findings and differential diagnosisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Currently available MDCT provides an excellent opportunity for reviewing the normal anatomy of the wall lumbar region and may be considered a useful modality for evaluating lumbar hernias. Content Type Journal ArticleCategory Anatomic Bases of Medical, Radiological and Surgical TechniquesPages 1-9DOI 10.1007/s00276-012-0937-8Authors Joaquín Martín, Department of Radiology, Hospital Reina Sofía, Ctra Tarazona km 3, 31500 Tudela, Navarra, SpainJosé María Mellado, Department of Radiology, Hospital Reina Sofía, Ctra Tarazona km 3, 31500 Tudela, Navarra, SpainSusana Solanas, Department o...
Source: Surgical and Radiologic Anatomy - February 3, 2012 Category: Anatomy Tags: Surgical and Radiologic Anatomy Source Type: research

Development and Implementation of a Web-Enabled 3D Consultation Tool for Breast Augmentation Surgery Based on 3D-Image Reconstruction of 2D Picturesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: We tested our tool for 3D, Web-based, patient-specific consultation in the clinical scenario of breast augmentation. This example shows that the current state of development allows for creation of responsive and effective Web-based, 3D medical tools, even with highly complex and time-consuming computation, by off-loading them to a dedicated high-performance data center. The efficient combination of advanced technologies, based on analysis and understanding of human anatomy and physiology, will allow the development of further Web-based reconstruction and predictive interfaces at different scales of the human b...
Source: Journal of Medical Internet Research - February 3, 2012 Category: Journals (General) Authors: Pablo de Heras CiechomskiMihai ConstantinescuJaime GarciaRadu OlariuIrving DindoyalSerge Le HuuMauricio Reyes Source Type: research

Computer tomographic evaluation of talar edge configuration for osteochondral graft transplantationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
AbstractTo successfully surgically reconstruct osteochondral lesions of the talus, the exact three‐dimensional (3D) configuration of the upper articular surface of the talus has to be respected. We assessed the talar geometry by measuring the coronal and sagittal talar edge radius and the frontal talar profile in multiplanar reconstructions of computer tomographic (CT) studies of 79 patients (83 feet) with a healthy ankle joint. An image visualization software designated for coordinate measurement was used to perform the measurement. In the coronal plane, the mean lateral talar edge radius was 4.0 mm and the medial 4.5 m...
Source: Clinical Anatomy - February 3, 2012 Category: Anatomy Authors: Martin WiewiorskiSebastian HoechelKatarina WishartAndré LeumannMagdalena Müller‐GerblVictor ValderrabanoAndrej Maria Nowakowski Tags: Original Communication Source Type: research

Pericardial Diseasesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This article presents the anatomy and physiology of pericardial disease and the clinical approach for diagnosis and treatment. (Source: Current Problems in Cardiology)
Source: Current Problems in Cardiology - February 2, 2012 Category: Cardiology Authors: David M. Dudzinski, Gary S. Mak, Judy W. Hung Source Type: research

President's Page: A Transformational Troikaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Irrespective of the field, be it religion (the 3 main Abrahamic religions, Hinduism, or Buddhism), philosophy (Hegel's dialectic), physics (baryon), chemistry (atomic constituents), or anatomy (human light perception), the underlying structure of 3's has been accorded considerable attention. (Source: Journal of the American College of Cardiology)
Source: Journal of the American College of Cardiology - February 2, 2012 Category: Cardiology Authors: David R. Holmes, Michael J. Mack Tags: FROM THE ACC Source Type: research

Dynamic FDG PET for assessing early effects of cerebral hypoxia and resuscitation in new-born pigsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  Dynamic FDG PET detected decreased cerebral glucose metabolism early after perinatal hypoxia in piglets. The decrease in CMRgl may indicate early changes of mild cerebral hypoxia–ischaemia. No significant effect of hyperoxic resuscitation on the degree of hypometabolism was found in this early phase after hypoxia. Cerebral FDG PET can provide new insights into mechanisms of perinatal hypoxic–ischaemic injury where early detection plays an important role in instituting therapy. Content Type Journal ArticleCategory Original ArticlePages 1-8DOI 10.1007/s00259-011-2055-yAuthors Charlotte ...
Source: European Journal of Nuclear Medicine and Molecular Imaging - February 2, 2012 Category: Radiology Tags: European Journal of Nuclear Medicine and Molecular Imaging Source Type: research

The anatomic study of clival screw fixation for the craniovertebral regionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Clival screw placement is a viable option for craniovertebral fixation. There is a safe scope for the screw length and angle of the screw placement. And, these parameters obtained in the present study will be helpful for anyone contemplating the use of clival screw fixation. Content Type Journal ArticleCategory Chinese sectionPages 1-9DOI 10.1007/s00586-012-2151-0Authors Wei Ji, Department of Orthopaedic Surgery, Second Affiliated Hospital of Wenzhou Medical College, 109 Xueyuanxi Road, Wenzhou, 325000 People’s Republic of ChinaXiang-Yang Wang, Department of Orthopaedic Surgery, Second...
Source: European Spine Journal - February 2, 2012 Category: Orthopaedics Tags: European Spine Journal Source Type: research

Compatibility of the HINTEGRA prostheses with Korean ankles as evaluated on the basis of cadaveric measurementsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
AbstractThe purpose of this study was to obtain anatomical measurements of the distal tibia and talus of Korean ankles and to evaluate, based on those measurements, the compatibility of the HINTEGRA prostheses in the context of total ankle replacement (TAR). We measured the length, width, height, and angles of the distal tibia and talus of 51 cadavers and compared these measurements with the corresponding dimensions of the HINTEGRA prostheses. The male ankles were larger than the female ones as was expected, but their overall shapes did not differ, which fact validates use of the prostheses irrespective of patients' sex. T...
Source: Clinical Anatomy - February 2, 2012 Category: Anatomy Authors: Sang Soo EunWoo‐Chun LeeSang‐Ho LeeDoo Jin PaikYoung‐Il Hwang Tags: Original Communication Source Type: research

A recurrent variant branch of the inferior alveolar nerve: Is it unique?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
In this study, a recurrent variant branch of the IAN arising just below the origin of the mylohyoid nerve was investigated in adult Indian cadavers allotted for dissection to the first year dental students of Government Dental College, Ahmedabad (India). The dissection was performed by the lateral approach to the infratemporal fossa. The nerve was found in 12 of 35 sides (34.3%) and 8 of 18 cadavers (44.4%). Thus, in our study it was not a rare variation of the IAN, where in most cases it innervated the lateral pterygoid muscle. In some cases, it terminated in the lateral pterygoid muscle. In others, it penetrated the musc...
Source: Clinical Anatomy - February 2, 2012 Category: Anatomy Authors: Hasmukh A. BuchRajendra G. Agnihotri Tags: Original Communication Source Type: research

Transhilar Passage in Right Graft Live Donor Liver Transplantation: Intrahilar Anatomy and Its Impact on Operative Strategyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The passage through the hilar plate during right graft live donor liver transplantation (LDLT) can have dangerous consequences for both donors and recipients. The purpose of our study was to delineate hilar transection and biliary reconstruction strategies in right graft LDLT, with special consideration of central and peripheral hilar anatomical variants. A total of 71 consecutive donors underwent preoperative three‐dimensional (3D) CT reconstructions and virtual 3D hepatectomies. A three‐modal hilar passage strategy was applied, and its impact on operative strategy analyzed. In 68.4% of cases, type I and II anatomical...
Source: American Journal of Transplantation - February 2, 2012 Category: Transplant Surgery Authors: A. RadtkeG. C. SotiropoulosE. P. MolmentiG. SgourakisT. SchroederS. BeckebaumH.‐O. PeitgenV. R. CicinnatiC. E. BroelschD. C. BroeringM. Malagó Source Type: research

Relationship Between Proximal Femoral and Acetabular Alignment in Normal Hip Joints Using 3-Dimensional Computed Tomographyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion: This study demonstrates that a correlation exists between multiple proximal femoral and acetabular angles in normal hip joints. These findings support the hypothesis that a complementary developmental relationship occurs between the femoral head and acetabulum. Clinical Relevance: The results of this study suggest that, in some patients, what is thought to be pathological acetabular retroversion may actually be normal anatomy with a compensated femoral version. Investigating the relationship between these angles in patients with the signs and symptoms of pincer-type femoroacetabular impingement may alte...
Source: The American Journal of Sports Medicine - February 2, 2012 Category: Sports Medicine Authors: Buller, L. T., Rosneck, J., Monaco, F. M., Butler, R., Smith, T., Barsoum, W. K. Tags: Imaging Studies, Hip/groin research-article Source Type: research

Histone deacetylases 2 and 9 are coexpressed and nuclear localized in human molar odontoblasts in vivoemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  Histone deacetylases (HDACs) are components of nuclear multiprotein complexes that deacetylate histones and perform important roles in repression of transcription. Using specific rabbit mAbs, we analyzed by immunohistochemistry and confocal immunofluorescence analysis the expression and subcellular localization of HDAC1–4 and HDAC9 in sections of adult human third molars. HDAC2 and HDAC9 were expressed in some pulpal cells and strongly expressed in the majority of mature odontoblasts. In contrast, only weak expression of HDAC1, HDAC3 and HDAC4 was observed. Confocal immunofluorescence analysis tog...
Source: Histochemistry and Cell Biology - February 1, 2012 Category: Biomedical Science Tags: Histochemistry and Cell Biology Source Type: research

Comparative tight junction protein expressions in colonic Crohn’s disease, ulcerative colitis, and tuberculosis: a new perspectiveemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  We intended to see the pattern of TJ protein expression along with ultrastructural changes in colonic biopsies from patients with Crohn’s disease (CD), ulcerative colitis (UC), and tuberculosis (cTB). Colonic biopsies from 11 patients with active CD and ten patients each with active UC and untreated cTB were taken along with biopsies from six patients with irritable bowel syndrome as controls. These were evaluated for expression pattern of key TJ proteins which included claudin-2 as TJ pore-forming protein, claudin-4 as pore-sealing protein, ZO-1 as scaffold protein, and occludin as TJ protein rel...
Source: Virchows Archiv - February 1, 2012 Category: Pathology Tags: Virchows Archiv Source Type: research

A retrospective review of pituitary MRI findings in children on growth hormone therapyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  Children with multiple pituitary hormone deficiencies were more likely to have the classic triad than children with isolated growth hormone deficiency. A normal MRI was the most common finding in children with isolated growth hormone deficiency. Content Type Journal ArticleCategory Original ArticlePages 1-6DOI 10.1007/s00247-012-2349-7Authors Sarah L. Tsai, Division of Endocrinology, Children’s Hospital of Eastern Ontario, University of Ottawa, 401 Smyth Road, Ottawa, Canada K1H 8L1Eoghan Laffan, Pediatric Radiology, Children’s University Hospital, Dublin 1, IrelandSarah Lawrence, Divi...
Source: Pediatric Radiology - February 1, 2012 Category: Radiology Tags: Pediatric Radiology Source Type: research

Single-Center Experience with Pediatric Laparoscopic Extravesical Reimplantation: Safe and Effective in Simple and Complex Anatomyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Journal of Laparoendoscopic & Advanced Surgical Techniques Jan 2012, Vol. 22, No. 1: 102-106. (Source: Journal of Laparoendoscopic)
Source: Journal of Laparoendoscopic - February 1, 2012 Category: Surgery Tags: article Source Type: research

Mom's Love Good For Child's Brainemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
School-age children whose mothers nurtured them early in life have brains with a larger hippocampus, a key structure important to learning, memory and response to stress. The new research, by child psychiatrists and neuroscientists at Washington University School of Medicine in St. Louis, is the first to show that changes in this critical region of children's brain anatomy are linked to a mother's nurturing. Their research is published online in the Proceedings of the National Academy of Sciences Early Edition... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 1, 2012 Category: Consumer Health News Tags: Pediatrics / Children's Health Source Type: news

Three-dimensional and molecular analysis of the arterial pole of the developing human heart.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract Labeling experiments in chicken and mouse embryos have revealed important roles for different cell lineages in the development of the cardiac arterial pole. These data can only fully be exploited when integrated into the continuously changing morphological context and compared with the patterns of gene expression. As yet, studies on the formation of separate ventricular outlets and arterial trunks in the human heart are exclusively based on histologically stained sections. So as to expand these studies, we performed immunohistochemical analyses of serially sectioned human embryos, along with three-dimensio...
Source: Journal of Anatomy - February 1, 2012 Category: Anatomy Authors: Sizarov A, Lamers WH, Mohun TJ, Brown NA, Anderson RH, Moorman AF Tags: J Anat Source Type: research

The use of design-based stereology to evaluate volumes and numbers in the liver: a review with practical guidelines.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract Stereology offers a number of tools for the analysis of sections in microscopy (which usually provide only two-dimensional information) for the purpose of estimating geometric quantities, such as volume, surface area, length or number of particles (cells or other structures). The use of these tools enables recovery of the three-dimensional information that is inherent in biological tissues. This review uses the liver as a paradigm for summarizing the most commonly used state-of-the-art methods for quantitation in design-based stereology. Because it is often relevant to distinguish hyperplasia and hypertrop...
Source: Journal of Anatomy - February 1, 2012 Category: Anatomy Authors: Marcos R, Monteiro RA, Rocha E Tags: J Anat Source Type: research

Gender-based differences in the shape of the human corpus callosum are associated with allometric variations.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract The corpus callosum displays considerable morphological variability between individuals. Although some characteristics are thought to differ between male and female brains, there is no agreement regarding the source of this variation. Biomedical imaging and geometric morphometrics have provided tools to investigate shape and size variation in terms of integration and correlation. Here we analyze variations at the midsagittal outline of the corpus callosum in a sample of 102 young adults in order to describe and quantify the pattern of covariation associated with its morphology. Our results suggest that the...
Source: Journal of Anatomy - February 1, 2012 Category: Anatomy Authors: Bruner E, de la Cuétara JM, Colom R, Martin-Loeches M Tags: J Anat Source Type: research

Brain Surface Conformal Parameterization With the Ricci Flowemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
In brain mapping research, parameterized 3-D surface models are of great interest for statistical comparisons of anatomy, surface-based registration, and signal processing. Here, we introduce the theories of continuous and discrete surface Ricci flow, which can create Riemannian metrics on surfaces with arbitrary topologies with user-defined Gaussian curvatures. The resulting conformal parameterizations have no singularities and they are intrinsic and stable. First, we convert a cortical surface model into a multiple boundary surface by cutting along selected anatomical landmark curves. Secondly, we conformally parameteriz...
Source: IEE Transactions on Medical Imaging - February 1, 2012 Category: Biomedical Engineering Source Type: research

Anatomic Bifurcated Reconstruction of Chronic Bilateral Innominate–Superior Vena Cava Occlusion Using the Y-Stenting Techniqueemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This article presents the case of a 42-year-old man who presented with superior vena cava (SVC) syndrome due to fibrosing mediastinitis with multiple failed attempts at recanalization. We initially treated him with unilateral sharp needle recanalization of the right innominate vein into the SVC stump followed by stenting. Although his symptoms improved immediately, they did not completely resolve. Six months later, he returned with worsening symptoms, and venography revealed in-stent restenosis. The patient requested simultaneous treatment on the left side. The right stent was dilated, and a 3-cm-long occlusion of the left...
Source: Annals of Vascular Surgery - February 1, 2012 Category: Surgery Authors: Parth Amin Tags: Case Report Abstracts Source Type: research

Novel echocardiographic techniques to assess left atrial size, anatomy and function.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Three-dimensional echocardiography (3DE) and speckle tracking echocardiography (STE) have recently applied as imaging techniques to accurately evaluate left atrial (LA) size, anatomy and function. 3DE and off-line quantification softwares, have allowed, in comparison to magnetic resonance imaging, the most time-efficient and accurate method of LA volume quantification. STE provides a non-Doppler, angle-independent and objective quantification of LA myocardial deformation. Data regarding feasibility, accuracy and clinical applications of LA analysis by 3DE and STE are rapidly gathering. This review describes the fundamental...
Source: Cardiovascular Ultrasound - February 1, 2012 Category: Radiology Authors: Matteo CameliMatteo LisiFrancesca Maria RighiniSergio Mondillo Source Type: research

Applied Surgical Anatomy of the Noseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Although anatomy often seems static, the continual innovation of new surgical techniques and approaches, in reality, make it a dynamic field. The first essential principal of any surgery is the comprehensive knowledge of the anatomic area and its physiology. This assertion is especially true in functional and or cosmetic nasal surgery. (Source: Oral and Maxillofacial Surgery Clinics)
Source: Oral and Maxillofacial Surgery Clinics - February 1, 2012 Category: ENT & OMF Authors: Mark R. Stevens, Hany A. Emam Source Type: research

Histological and ultrastructural abnormalities in murine desmoglein 2-mutant heartsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  Mice carrying a deletion of the adhesive extracellular domain of the desmosomal cadherin desmoglein 2 develop an arrhythmogenic right ventricular cardiomyopathy-like phenotype with ventricular dilation, fibrosis and arrhythmia. To unravel the sequence of myocardial alterations and to identify potential pathomechanisms, histological analyses were performed on mutant hearts from the juvenile to the adult state, i.e., between 2 and 13 weeks. At an age of 2 weeks 30% of mutants presented lesions, which were visible as white plaques on the heart surface or in the septum. From 4 weeks onwar...
Source: Cell and Tissue Research - January 31, 2012 Category: Cytology Tags: Cell and Tissue Research Source Type: research

Grisel’s syndrome: a comprehensive review with focus on pathogenesis, natural history, and current treatment optionsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion  GS remains a rare, but potentially lethal children condition. Early diagnosis and treatment is crucial to its management and prognosis. Content Type Journal ArticleCategory Review PaperPages 1-5DOI 10.1007/s00381-012-1706-zAuthors Stephen Osiro, Department of Anatomical Sciences, School of Medicine, St. George’s University, Grenada West IndiesKevin J. Tiwari, Department of Anatomical Sciences, School of Medicine, St. George’s University, Grenada West IndiesPetru Matusz, Department of Anatomy, Victor Babes University of Medicine and Pharmacy, Timisoara, RomaniaJerzy Gielecki, Department...
Source: Child's Nervous System - January 31, 2012 Category: Pediatrics Tags: Child's Nervous System Source Type: research

Erythropoietin attenuates 6-hydroxydopamine-induced apoptosis via glycogen synthase kinase 3β-mediated mitochondrial translocation of Bax in PC12 cellsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  The aim of this study was to determine the mechanism by which erythropoietin (EPO) suppressed 6-hydroxydopamine (6-OHDA)-induced apoptosis. Our results showed that 6-OHDA remarkably decreased phosphorylation of glycogen synthase kinase 3β (GSK3β) as well as enhanced the level of Bax in the mitochondria. Besides, 6-OHDA decreased the mitochondrial expression of Bcl-2 without altering the cytoplasmic expression of Bcl-2. In line with these results, 6-OHDA treatment enhanced the apoptosis and caspase 3 activity in PC12 cells. These findings indicated that mitochondrial dysfunction was involved in the...
Source: Neurological Sciences - January 31, 2012 Category: Neurology Tags: Neurological Sciences Source Type: research

Functional consequences of a section of the anterior part of the body of the corpus callosum: evidence from an interhemispheric transcallosal approachemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  The aim of this study was to determine the neuropsychological consequences of a middle interhemispheric approach for the removal of tumors of the third or lateral ventricles. A retrospective analysis of eight callosotomized patients for ventricular tumors (three males/five females; mean age: 48.7 ± 11.2 years; education level: 11.9 ± 2.9 years) and eight healthy subjects was performed. An extensive neuropsychological test battery was used to evaluate global intellectual efficiency, memory capacities, executive functions, and interhemispheric transfer of a procedural l...
Source: Journal of Neurology - January 31, 2012 Category: Neurology Tags: Journal of Neurology Source Type: research

Epigenetics and its role in male infertilityemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  Male infertility is a common and complex problem affecting 1 in 20 men. Despite voluminous research in this field, in many cases, the underlying causes are unknown. Epigenetic factors play an important role in male infertility and these have been studied extensively. Epigenetic modifications control a number of processes within the body, but this review will concentrate on male fertility and the consequences of aberrant epigenetic regulation/modification. Many recent studies have identified altered epigenetic profiles in sperm from men with oligozoospermia and oligoasthenoteratozoospermia. During ga...
Source: Journal of Assisted Reproduction and Genetics - January 31, 2012 Category: Reproduction Medicine Tags: Journal of Assisted Reproduction and Genetics Source Type: research

HCC: current surgical treatment conceptsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  The improvement of survival in HCC patients after surgical treatment results from refinements in surgical technique and better identification of adverse prognostic factors. Content Type Journal ArticleCategory Review ArticlePages 1-15DOI 10.1007/s00423-012-0911-2Authors F. Cauchy, Beaujon Hospital, Assistance Publique Hôpitaux de Paris, Clichy, France, University Denis Diderot-Paris 7, Paris, FranceD. Fuks, Beaujon Hospital, Assistance Publique Hôpitaux de Paris, Clichy, France, University Denis Diderot-Paris 7, Paris, FranceJ. Belghiti, Beaujon Hospital, Assistance Publique Hôpitaux d...
Source: Langenbeck's Archives of Surgery - January 31, 2012 Category: Surgery Tags: Langenbeck's Archives of Surgery Source Type: research

Uberon, an integrative multi-species anatomy ontologyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
A description of the Uberon ontology tool that allows comparisons of genomic information across multiple animal phyla (Source: Genome Biology)
Source: Genome Biology - January 31, 2012 Category: Genetics & Stem Cells Authors: Christopher MungallCarlo TorniaiGeorgios GkoutosSuzanna LewisMelissa Haendel Source Type: research

Early Visualization and Measurement of the Pericallosal Artery: An Indirect Sign of Corpus Callosum Developmentemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions— Our data show that it is feasible to visualize and measure the pericallosal artery from an early stage of gestation, and this measurement could be an indirect indication of normal corpus callosum development. (Source: Journal of Ultrasound in Medicine)
Source: Journal of Ultrasound in Medicine - January 31, 2012 Category: Radiology Authors: Pati, M., Cani, C., Bertucci, E., Re, C., Latella, S., D'Amico, R., Mazza, V. Tags: Original Research Source Type: research

Dose dependence and temporal evolution of the T1 relaxation time and MRI contrast in the rat brain after subcutaneous injection of manganese chlorideemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
AbstractDivalent manganese ion (Mn2+) is a widely used T1 contrast agent in manganese‐enhanced MRI studies to visualize functional neural tracts and anatomy in the brain in vivo. In animal studies, Mn2+ is administered at a dose that will maximize the contrast, while minimizing its toxic effects. In rodents, systemic administration of Mn2+ via intravenous injection has been shown to create unique MRI contrast in the brain at a maximum dose of 175 mg kg−1. However, intravenous administration of Mn2+ results in faster bioelimination of excess Mn2+ from the plasma due to a steep concentration gradient between plasma and b...
Source: Magnetic Resonance in Medicine - January 31, 2012 Category: Radiology Authors: Mohammed Salman ShazeebChristopher H. Sotak Tags: Full Paper Source Type: research

Netter's Anatomy Atlas for iPad [Book and Media Reviews]email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: JAMA)
Source: JAMA - January 31, 2012 Category: Journals (General) Authors: Smith, R. P. Tags: Informatics/ Internet in Medicine, Medical Practice, Medical Education Book and Media Reviews Source Type: research

Cephalometric analysis for microvascular head and neck reconstructionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
ConclusionWhen premorbid craniofacial anatomy cannot be discerned in the setting of extensive trauma or tumor involvement, normative dimensions may be a helpful guide for flap design and should be in the armamentarium of surgeons engaged in complex head and heck reconstruction. © 2012 Wiley Periodicals, Inc. Head Neck, 2012 (Source: Head and Neck)
Source: Head and Neck - January 31, 2012 Category: ENT & OMF Authors: Edward I. ChangMark W. ClemensPatrick B. GarveyRoman J. SkorackiMatthew M. Hanasono Tags: Original Article Source Type: research

Foot anomalies and proximal symphalangismemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
We report the case of a 2‐week‐old girl born at term (by vaginal delivery and without antenatal or perinatal events) who was referred as having “bilateral talipes and bilateral proximal symphalangism of little and ring fingers.” The “talipes” was atypical with marked equinus and varus, but no cavus or adductus of the midfoot. Her mother had both symphalangism (absence of proximal interphalangeal joints) of middle, ring, and little fingers bilaterally and fixed pes planus with a rigid fixed hindfoot—and these deformities had also been present from birth. The maternal grandmother was similarly affected. However...
Source: Clinical Anatomy - January 31, 2012 Category: Anatomy Authors: Lauren ShawJanet McCaulGreg J. IrwinJames S. Huntley Tags: Problems in Diagnostic Imaging Source Type: research

Jacob B. Winslow (1669–1760)email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
AbstractJacob Winslow was a Dutch born, French naturalized anatomist and physician whose contributions to medicine are abundant. His importance to medicine is undisputed. His personal life included a religious crisis that resulted in his estrangement from his family, but afforded him patrons in Paris to continue his work. Following this conversion, he changed his name to that of his catechist and was rechristened Jacques Benigne Wilson. His respect as an expert was well deserved, and he held several prominent positions during his career in Paris. His main work, Exposition anatomique de la structure du corps humain, was pub...
Source: Clinical Anatomy - January 31, 2012 Category: Anatomy Authors: Sharath S. BellaryAndrew WaltersJerzy GieleckiMohammadali M. ShojaR. Shane TubbsMarios Loukas Tags: A Glimpse of Our Past Source Type: research

Pericardiocentesis: A clinical anatomy reviewemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
AbstractThe safe and successful performance of pericardiocentesis demands a working and specific knowledge of anatomy. Misunderstanding of anatomy may result in failure or serious complications. This review attempts to aid understanding of the anatomical framework, pitfalls, and complications of pericardiocentesis. Pericardiocentesis is carried out for aspiration of blood from the pericardial cavity in cases of cardiac tamponade and symptomatic pericardial effusion. In addition, this technique may be used for the diagnosis of neoplastic effusions, purulent pericarditis, and introduction of cytotoxic agents into the pericar...
Source: Clinical Anatomy - January 31, 2012 Category: Anatomy Authors: M. LoukasA. WaltersJ.M. BoonT.P. WelchJ.H. MeiringP.H. Abrahams Tags: Review Source Type: research

Investigations on the conjunctival goblet cells and the characteristics of the glands associated with the eye in chinchillas (Chinchilla Laniger)email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  Chinchillas possess a Harderian gland, a lacrimal gland, and Meibomian glands. The GC density in the nasal and temporal palpebral conjunctiva is higher than in guinea pigs. (Source: Veterinary Ophthalmology)
Source: Veterinary Ophthalmology - January 31, 2012 Category: Veterinary Research Authors: Susanne VoigtAndrea Fuchs‐BaumgartingerMonika EgerbacherAlexander TichyBarbara Nell Source Type: research

Late repair of the native pulmonary valve in patients with pulmonary insufficiency after surgery for tetralogy of fallot.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This article summarizes our experience with 5 patients who underwent reoperations for treatment of severe pulmonary regurgitation after transannular patch repair of tetralogy of Fallot. In each case, the intraoperative findings revealed anatomy favorable for valve repair and enabled preservation of the native pulmonary valves. PMID: 22269747 [PubMed - in process] (Source: The Annals of Thoracic Surgery)
Source: The Annals of Thoracic Surgery - January 30, 2012 Category: Cardiovascular & Thoracic Surgery Authors: Mainwaring RD, Pirolli T, Punn R, Hanley FL Tags: Ann Thorac Surg Source Type: research

Influence of the initial rupture size and tendon subregion on three-dimensional biomechanical properties of single-row and double-row rotator cuff reconstructionsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions  The tested single-row repair using a modified suture configuration achieved superior results in three-dimensional measurements of cyclic displacement compared to the tested double-row suture-bridge repair. The results were dependent on the initial rupture size of the rotator cuff tear. Furthermore, significant differences were found between tendon subregions of the rotator cuff with significantly higher gap formation for the anterior compared to the posterior subregions. Content Type Journal ArticleCategory ShoulderPages 1-9DOI 10.1007/s00167-012-1892-yAuthors O. Lorbach, Department of ...
Source: Knee Surgery, Sports Traumatology, Arthroscopy - January 30, 2012 Category: Orthopaedics Tags: Knee Surgery, Sports Traumatology, Arthroscopy Source Type: research

Antidiabetic effect of Orchis anatolica root extracts on alloxan-induced diabetic ratsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  The aim of our study was to evaluate the effect of Orchis anatolica roots ethanol extraction on alloxan-induced diabetic rats. Thirty-six albino rats (200 g) were used in this experiment and divided into six groups. Diabetes was induced in five rat groups by a single intraperitoneal injection of alloxan (150 mg/kg body weight). After hyperglycemia was conformed, one rat group was considered as diabetic control and one group was treated with glibenclamide (10 mg/kg body weight/daily) where the remaining three groups received daily treatments with three different doses of O. anatolica e...
Source: Comparative Clinical Pathology - January 30, 2012 Category: Pathology Tags: Comparative Clinical Pathology Source Type: research

Endoscopic Endonasal Transsphenoidal Exposure of Circle of Willis (Cw); Can It be Applied in Vascular Neurosurgery in the Near Future? A Cadaveric Study of 26 Cases.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CONCLUSION: Endoscopic endonasal extended transsphenoidal exposure of CW can make the surgeon more efficient in removing midline skullbase lesions with safe handling of different parts of circle of Willis and it may help in development of endonasal endoscopic vascular neurosurgery in the near future. PMID: 22274974 [PubMed - in process] (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - January 30, 2012 Category: Neurosurgery Authors: Chowdhury FH, Haque MR, Kawsar KA, Ara S, Mohammod QD, Sarker MH, Goel AH Tags: Turk Neurosurg Source Type: research

Improving yield by exploiting mechanisms underlying natural variation of photosynthesis.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract Increasing photosynthesis in C3 species has been identified as an approach to increase the yield of crop plants. Most of our knowledge of photosynthetic performance has come from studies in which plants were grown in controlled growth conditions but plants in natural environments have to cope with unpredictable and rapidly changing conditions. Plants adapt to the light environment in which they grow and this is demonstrated by the differences in anatomy and morphology of leaves in sun and shade leaves. Superimposed on this are the dynamic responses of plants to rapid changes in the light environment that o...
Source: Current Opinion in Biotechnology - January 30, 2012 Category: Biotechnology Authors: Lawson T, Kramer DM, Raines CA Tags: Curr Opin Biotechnol Source Type: research

The Virtual Fly Brain browser and query interfaceemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
We present an online resource that provides a convenient way to study and query fly brain anatomy, expression and genetic data. We extended the newly developed BrainName nomenclature for the adult fly brain into a logically structured ontology that relates a comprehensive set of published neuron classes to the brain regions they innervate. The Virtual Fly Brain interface allows users to explore the structure of the Drosophila brain by browsing 3D images of a brain with subregions displayed as coloured overlays. An integrated query mechanism allows complex searches of underlying anatomy, cells, expression and other data fro...
Source: Bioinformatics - January 30, 2012 Category: Bioinformatics Authors: Milyaev, N., Osumi-Sutherland, D., Reeve, S., Burton, N., Baldock, R. A., Armstrong, J. D. Tags: DATABASES AND ONTOLOGIES Source Type: research