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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 38.
In vivo 3 T MR diffusion tensor imaging for detection of the fibre architecture of the human uterus: a feasibility and quantitative study.
Conclusion: Fibre architecture of the human uterus can be depicted in vivo using 3 T MR-DTI.Advances in knowledge: 3 T MR-DTI can help to have an in vivo insight of uterine anatomy non-invasively, especially in females with previous Caesarean surgery, in order to provide better management of subsequent deliveries. PMID: 22744322 [PubMed - as supplied by publisher]
Source: The British Journal of Radiology - June 27, 2012 Category: Radiology Authors: Fiocchi F, Nocetti L, Siopis E, Currà S, Costi T, Ligabue G, Torricelli P Tags: Br J Radiol Source Type: research
Filamin A mutation associated with normal reading skills and dyslexia in a family with periventricular heterotopia
AbstractPeriventricular heterotopia (PH) is a disorder of neuronal migration during fetal development that is characterized by morphologically normal neurons being located in an anatomically abnormal position in the mature brain. PH is usually diagnosed in patients presenting with a seizure disorder, when neuroimaging demonstrates the ectopically placed nodules of neurons. PH is a genetically and phenotypically heterogeneous disorder. The most commonly identified genetic cause is the X‐linked dominant inheritance of mutations in the Filamin A (FLNA) gene. Multiple lines of evidence support the contribution of genetic fac...
Source: American Journal of Medical Genetics Part A - June 27, 2012 Category: Genetics & Stem Cells Authors: Eyal Reinstein, Bernard S. Chang, Stephen P. Robertson, David L. Rimoin, Tami Katzir Tags: Research Article Source Type: research
Importance of conserving middle hepatic vein distal branches for homogeneous regeneration of the left liver after right hepatectomy
Conclusions: It is crucial to conserve the MHV in its distal part if homogeneous left liver regeneration after right hepatectomy that will allow potential repeat liver resection is to be achieved.
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - June 27, 2012 Category: Gastroenterology Authors: Francois Faitot, Eric Vibert, Chady Salloum, David Lee Gorden, Franck Coscas, René Adam, Denis Castaing Source Type: research
The circadian clock network in the brain of different Drosophila species
AbstractComparative studies on cellular and molecular clock mechanisms have revealed striking similarities in the organization of the clocks among different animal groups. To gain evolutionary insight into the properties of the clock network within the Drosophila genus, we analyzed sequence identities and similarities of clock protein homologues and immunostained brains of ten different Drosophila species using antibodies against VRILLE (VRI), PAR‐Protein Domain1 (PDP1) and CRYPTOCHROME (CRY). We found that the clock network of both subgenera Sophophora and Drosophila consists of all lateral and dorsal clock neuron clust...
Source: The Journal of Comparative Neurology - June 27, 2012 Category: Neurology Authors: Christiane Hermann, Rachele Saccon, Pingkalai R. Senthilan, Lilith Domnik, Heinrich Dircksen, Taishi Yoshii, Charlotte Helfrich‐Förster Tags: Research Article Source Type: research
Management of the failing Fontan circulation
The ‘Fontan circulation' has evolved to include a variety of surgical procedures designed to overcome the absence of two distinct ventricular chambers.1 w1–w3 Inherent to this circulation is chronic elevation of right atrial and vena caval pressure, and absence of a dedicated power source to serve the pulmonary circulation, making low pulmonary vascular resistance and optimal systemic ventricular function the essential ingredients of a successful Fontan circulation.2 Originally designed for the single left ventricle, modifications to the original atriopulmonary connections extended repairs to complex ventricula...
Source: Heart - June 27, 2012 Category: Cardiology Authors: Deal, B. J., Jacobs, M. L. Tags: Tachyarrhythmias, Congenital Heart Disease, Education in Heart, Unlocked, Congenital heart disease, Drugs: cardiovascular system, Interventional cardiology, Epidemiology Source Type: research
Odontoblast response to cavity preparation with Er:YAG laser in rat molars: an immunohistochemical study
This study aimed to examine the dynamics of odontoblast-lineage cells following cavity preparation with erbium:yttrium–aluminum-garnet (Er:YAG) laser in rat molars. Cavity preparation was made with Er:YAG laser in the mesial surface of the maxillary left first molar of 8-week-old Wistar rats. Contralateral first molar served as unirradiated control. Immediately, 6 and 12 h and 1, 2, 3, 5 and 7 days after the lasing (n = 5, each), specimens were collected and processed for immunohistochemistry for heat-shock protein (HSP)-25 and nestin as markers for odontoblast-lineage cells. Cell proliferation as...
Source: Odontology - June 26, 2012 Category: Dentistry Tags: Odontology Source Type: research
L5 Pedicle Length Is Increased in Subjects With Spondylolysis: An Anatomic Study of 1072 Cadavers.
CONCLUSIONS: In spondylolytic specimens, there is progressive elongation of L5 pedicle length after the third decade. An increase in L5 pedicle length in all age groups compared with the specimens from healthy subjects suggests that pathologic changes occur in bony anatomy of L5 vertebrae as early as adolescence when the condition develops. PMID: 22733185 [PubMed - as supplied by publisher]
Source: Clinical Orthopaedics and Related Research - June 26, 2012 Category: Orthopaedics Authors: Bajwa NS, Toy JO, Ahn NU Tags: Clin Orthop Relat Res Source Type: research
Bone Morphology of the Hind Limbs in Two Caviomorph Rodents
SummaryIn order to evaluate the hind limbs of caviomorph rodents a descriptive analysis of the Cuniculus paca (Linnaeus, 1766) and Hydrochoerus hydrochaeris (Linnaeus, 1766) was performed using anatomical specimens, radiography, computed tomography (CT) and full‐coloured prototype models to generate bone anatomy data. The appendicular skeleton of the two largest rodents of Neotropical America was compared with the previously reported anatomical features of Rattus norvegicus (Berkenhout, 1769) and domestic Cavia porcellus (Linnaeus, 1758). The structures were analyzed macroscopically and particular findings of each specie...
Source: Anatomia, Histologia, Embryologia: Journal of Veterinary Medicine Series C - June 26, 2012 Category: Veterinary Research Authors: F. A. P. Araújo, N. F. Sesoko, S. C. Rahal, C. R. Teixeira, T. R. Müller, M. R. F. Machado Tags: Original Article Source Type: research
Independent and Confluent Middle Mesial Root Canals in Mandibular First Molars: A Report of Four Cases
Mandibular molars demonstrate considerable variations with respect to number of roots and root canals. The possibility of additional root canals should be considered even in teeth with a low frequency of abnormal root canal anatomy. This paper discusses the endodontic management of the rare anatomical complexity middle mesial canals in mandibular first molar and also serves to remind the clinicians that such anatomical variations should be taken into account during the endodontic treatment of the mandibular molars.
Source: Experimental Diabetes Research - June 25, 2012 Category: Endocrinology Source Type: research
Comparison of thoracic wall behavior in large animals and human cadavers submitted to an identical ballistic blunt thoracic trauma
Conclusion: The motion of the pig's thoracic wall is greater than that of the human cadaver, and the severity of the impact is always greater for human cadavers than for pigs. In addition, pig bone is more elastic and less brittle than older human cadaver bone. Due to the bone mineral density, the thoracic wall of human adults should be more rigid and more resistant than the thoracic wall of human cadavers or pigs.
Source: Forensic Science International - June 25, 2012 Category: Forensic Medicine Authors: Nicolas Prat, Frédéric Rongieras, Humbert de Freminville, Pascal Magnan, Eric Debord, Thierry Fusai, Casimir Destombe, Jean-Claude Sarron, Eric J. Voiglio Tags: Research Articles Source Type: research
Dream content changes in women after mastectomy: An initial study of body imagery after body-disfiguring surgery.
The changes in body perception after invasive surgery and their internalization in dreams have been mostly neglected in the literature on dreams. We evaluated consecutive newly diagnosed patients with breast cancer about their dream content, sleep quality and quantity, and their mood both before and after the surgical intervention (T0 and T1), to determine whether the loss of a body part with specific sexual features (such as the breast) could change body schema and actuate a sexual sphere restructuring. Dream content was coded according to the Hall and Van de Castle (1966) method. Results were analyzed to compare T0, T1, ...
Source: Dreaming - June 25, 2012 Category: Psychiatry & Psychology Authors: Giordano, Alessandra; Francese, Valentina; Peila, Elena; Tribolo, Antonella; Airoldi, Mario; Torta, Riccardo; Mutani, Roberto; Cicolin, Alessandro Source Type: research
Guide to Surgical Procedures on Hollow Viscera: Part 2--Colorectal, Ostomy, and Malabsorptive Bariatric Procedures
CONCLUSION. An understanding of procedures on the hollow viscera is essential for a radiologist at any level. The ability to quickly recognize postoperative anatomy is critical to accurately and efficiently interpret routine imaging studies and to diagnose postoperative complications.
Source: American Journal of Roentgenology - June 25, 2012 Category: Radiology Authors: Roberts, A., Fanous, R., Jaffer, N. M., McLeod, R., Chawla, T. P., Au, W. F., Ghai, S. Tags: Integrative Imaging Self-Assessment Modules LIFELONG LEARNING FOR RADIOLOGY Source Type: research
Guide to Surgical Procedures on Hollow Viscera: Part 1--Esophageal, Gastric, and Restrictive Bariatric Procedures
CONCLUSION. An understanding of procedures on the hollow viscera is essential for radiologists at any level. The ability to quickly recognize postoperative anatomy is critical to accurately and efficiently interpret routine imaging studies and to diagnose postoperative complications.
Source: American Journal of Roentgenology - June 25, 2012 Category: Radiology Authors: Roberts, A., Fanous, R., Jaffer, N. M., McLeod, R., Chawla, T. P., Au, W. F., Ghai, S. Tags: Integrative Imaging Self-Assessment Modules LIFELONG LEARNING FOR RADIOLOGY Source Type: research
Rectal Imaging: Part 2, Perianal Fistula Evaluation on Pelvic MRI--What the Radiologist Needs to Know
CONCLUSION. MRI evaluation of perianal fistulas can be challenging, and knowledge of relevant pelvic anatomy and fistula classification remains crucial in the diagnosis. MRI is highly accurate for fistula depiction and, by providing an accurate assessment of disease status and extension, can help surgical planning to minimize recurrence and detect clinically unapparent disease.
Source: American Journal of Roentgenology - June 25, 2012 Category: Radiology Authors: O'Malley, R. B., Al-Hawary, M. M., Kaza, R. K., Wasnik, A. P., Liu, P. S., Hussain, H. K. Tags: Integrative Imaging Self-Assessment Modules LIFELONG LEARNING FOR RADIOLOGY Source Type: research
Acute carpal tunnel syndrome in trauma
This article describes acute CTS in detail and provides information for correct and early diagnosis together with effective treatment. The risk factors and treatment options are discussed in detail with photographic illustrations, providing simple but comprehensive material for education of students and clinicians, therefore to improve outcome of patients with this potentially devastating condition. Content Type Journal ArticleCategory ReviewPages 1-8DOI 10.1007/s00238-012-0732-0Authors Hardeep Jhattu, Department of Plastic, Reconstructive and Hand Surgery, The Canberra Hospital, Canberra, ACT 2605, AustraliaSoph...
Source: European Journal of Plastic Surgery - June 23, 2012 Category: Cosmetic Surgery Tags: European Journal of Plastic Surgery Source Type: research
Preponderance of inhibitory versus excitatory intramuscular nerve fibres in human chagasic megacolon
Discussion and conclusion We suggest that preponderance of inhibitory, intramuscular nerve fibres may be one factor explaining the chronic dilation. Since the nerve fibre imbalance is most pronounced in the anal, non-dilated segment, other components of the motor apparatus (musculature, interstitial cells, submucosal neurons) have to be considered. Content Type Journal ArticleCategory Original ArticlePages 1-9DOI 10.1007/s00384-012-1500-0Authors Samir Jabari, Institute of Anatomy I, University of Erlangen–Nuremberg, Krankenhausstrasse 9, 91054 Erlangen, GermanyAlexandre B. M. da Silveira, Human An...
Source: International Journal of Colorectal Disease - June 23, 2012 Category: Gastroenterology Tags: International Journal of Colorectal Disease Source Type: research
A case of the geniculate artery pseudoaneurysm after total knee arthroplasty: search for preventive measures by evaluation of arterial anatomy of cadaver knees
In conclusion, careful subperiosteal release around the geniculate arteries is recommended. However, early recognition of pseudoaneurysm formation is even more essential than prevention. Level of evidence Therapeutic study, Level IV. Content Type Journal ArticleCategory KneePages 1-4DOI 10.1007/s00167-012-2109-0Authors Mitsuaki Noda, Department of Orthopedics, Konan Hospital, 1-5-16 Kamokogahara, Higashinada-ku, Kobe, 658-0064 JapanYasuhiro Saegusa, Department of Orthopedics, Konan Hospital, 1-5-16 Kamokogahara, Higashinada-ku, Kobe, 658-0064 JapanMasayasu Takahashi, Department of Orthopedics, Konan Hospit...
Source: Knee Surgery, Sports Traumatology, Arthroscopy - June 23, 2012 Category: Orthopaedics Tags: Knee Surgery, Sports Traumatology, Arthroscopy Source Type: research
Isolated bilateral external iliac vein aplasia
We present a case of 11-year-old girl with a history of prominent superficial veins over abdomen and thorax since birth. A superficial vein extending from either inguinal region joined in umbilical region and extended up to right supraclavicular region. Other features of Klippel–Trenaunay syndrome like nevus, limb edema were absent. On radiological investigations both external iliac veins could not be visualized and venous return from lower limbs was draining into the right subclavian vein via these superficial veins. Both external iliac veins could not be identified during surgery. Content Type Journal ArticleC...
Source: Surgical and Radiologic Anatomy - June 23, 2012 Category: Anatomy Tags: Surgical and Radiologic Anatomy Source Type: research
Tissue-engineered bone grafts for osteoplasty in patients with cleft alveolus.
Abstract Alveolar bone grafting is an integral part of the treatment concept in cleft palate patients. As an alternative to autogenous bone, tissue-engineered grafts have found some clinical application. The aim of the present study has been to compare ossification in the cleft area using tissue-engineered grafts in a case series of patients with ossification after transplantation of autogenous spongious bone as the gold standard in alveoloplasty. Eight children with complete cleft lips and cleft palates were included in the study. In four children (group A), the cleft defect was filled with tissue-engineered bone ...
Source: Annals of Anatomy - June 23, 2012 Category: Anatomy Authors: Pradel W, Lauer G Tags: Ann Anat Source Type: research
Is the frontal dysexecutive syndrome due to a working memory deficit? Evidence from patients with stroke
This study reveals that frontal lesions induce mild impairment of short-term memory associated with a deficit of the rehearsal process supporting the role of the frontal lobe in this process; the central executive depends on lesions in the frontal lobe and posterior regions accounting for its low frequency and the negative results of group studies. Finally, the frontal dysexecutive syndrome cannot be attributed to central executive impairment, although it may contribute to some dysexecutive disorders.
Source: Brain - June 23, 2012 Category: Neurology Authors: Roussel, M., Dujardin, K., Henon, H., Godefroy, O. Tags: Original Articles Source Type: research
Prevalence of accessory pudendal artery
This study investigated the frequency of an accessory pudendal artery in 15 adult cadavers fixed with formaldehyde solution. The prevalence of accessory pudendal artery varies between 7 and 75% according to the method of identification (imaging studies, microstereoscopic cadaveric dissection, and open and laparoscopic surgeries). Currently, under discussion is the role of this artery in postprostatectomy erectile dysfunction. Accordingly, it is important to know the true prevalence to appreciate its clinical significance. The internal pudendal system was examined through direct dissection, and findings were compared with t...
Source: Clinical Anatomy - June 22, 2012 Category: Anatomy Authors: R. Allan, N.A. García, J.M. Montenegro, J.N.M. Álvarez‐Alberó Tags: Compendium of Anatomical Variants Source Type: research
Anatomo-radiological study of the superior semicircular canal dehiscence of 37 cadaver temporal bones
Conclusion This study emphasizes the limitations of CT imaging, with a risk of false positives to take into account when interpreting the images. The 3D reconstructions also give too many false positives to be used alone and make an accurate diagnosis. The diagnosis of SSCC dehiscence will therefore remain clinical. Complementary and instrumental radiological examinations should be performed only to confirm this clinical suspicion. Content Type Journal ArticleCategory Anatomic Bases of Medical, Radiological and Surgical TechniquesPages 1-5DOI 10.1007/s00276-012-0992-1Authors Michel Mondina, ENT and...
Source: Surgical and Radiologic Anatomy - June 22, 2012 Category: Anatomy Tags: Surgical and Radiologic Anatomy Source Type: research
The double suprascapular foramen: unique anatomical variation and the new hypothesis of its formation
Abstract A unique anatomical variation of the suprascapular notch was discovered in one scapula from 610 analyzed by three-dimensional CT reconstruction. Two bony bridges were found, converting it into a double suprascapular foramen, in the left upper extremity of an 56-year-old Caucasian female. This variation might be a risk factor for suprascapular nerve entrapment. Suprascapular nerve running through inferior suprascapular foramen was discovered. Suprascapular vessels passed through superior suprascapular foramen (artery lay medially and vein laterally). A new hypothesis of double suprascapular foramen f...
Source: Skeletal Radiology - June 22, 2012 Category: Radiology Tags: Skeletal Radiology Source Type: research
MRI of Hip Cartilage: Joint Morphology, Structure, and Composition.
Abstract BACKGROUND: Accurate, reproducible, and noninvasive assessment of hip cartilage is clinically relevant and provides a means by which to assess the suitability of candidates for arthroscopic or open surgical procedures and the response to such interventions over time. Given the relatively thin cartilage of the hip and the complex spherical anatomy, however, accurately assessing the cartilage poses a challenge for traditional MRI techniques. QUESTIONS/PURPOSES: We assessed the current status of imaging articular cartilage of the hip through a comprehensive review of ...
Source: Clinical Orthopaedics and Related Research - June 22, 2012 Category: Orthopaedics Authors: Gold SL, Burge AJ, Potter HG Tags: Clin Orthop Relat Res Source Type: research
The role of patient, surgical, and implant design variation in total knee replacement performance
Abstract: Clinical studies demonstrate substantial variation in kinematic and functional performance within the total knee replacement (TKR) patient population. Some of this variation is due to differences in implant design, surgical technique and component alignment, while some is due to subject-specific differences in joint loading and anatomy that are inherently present within the population. Combined finite element and probabilistic methods were employed to assess the relative contributions of implant design, surgical, and subject-specific factors to overall tibiofemoral (TF) and patellofemoral (PF) joint mechanics, in...
Source: Journal of Biomechanics - June 22, 2012 Category: Biomedical Science Authors: Clare K. Fitzpatrick, Chadd W. Clary, Paul J. Rullkoetter Tags: Papers Source Type: research
Morphology of Maxillary First and Second Molars Analyzed by Cone-Beam Computed Tomography in a Korean Population: Variations in the Number of Roots and Canals and the Incidence of Fusion
Conclusions: The root and canal configuration of a Korean population showed different features from those of other populations. We report the incidence of rare morphologic variations, a single root and 3 buccal roots, that have not been described except for in case reports. CBCT scans can enhance the understanding of root canal anatomy, with the potential of improving the outcome of endodontic treatment.
Source: Journal of Endodontics - June 22, 2012 Category: Dentistry Authors: Yemi Kim, Seung-Jong Lee, Jein Woo Tags: Clinical Research Source Type: research
Epiphyseal maturity indicators at the knee and their relationship to chronological age: Results of an Irish population study
This study aims to investigate radiographically the age at which morphological changes of the epiphyses at the knee occur in a modern Irish population. Radiographs of 221 subjects (137 males; 84 females) aged 9–19 years were examined. Seven nonmetric indicators of maturity were assessed using criteria modified from the Roche, Wainer, and Thissen method and Pyle and Hoerr's atlas of the knee. Reference charts are presented which display the timeline for each of the grades of development of the seven indicators. Mean age was found to increase significantly with successive grades of development of each of the seven indicato...
Source: Clinical Anatomy - June 22, 2012 Category: Anatomy Authors: Jean E. O'Connor, Joseph Coyle, Liam D. Spence, Jason Last Tags: Original Communication Source Type: research
[Tumors of the foot: diagnostics and therapy.]
Abstract Despite the compact anatomy with thin soft tissue coverage, diagnosis of both benign and malignant tumors of the foot is often delayed. Diagnostic errors are more common than in other body regions, as neoplasias are rarely considered. Barring a few exceptions the foot is not a typical predilection site for malignant musculoskeletal tumors, although, basically any tumor entity of the musculoskeletal system can affect the foot. Delays in specific diagnostic and therapeutic procedures of these lesions can entail serious consequences for patients as tumor size is a major prognostic factor for recurrence-free s...
Source: Der Orthopade - June 22, 2012 Category: Orthopaedics Authors: Toepfer A, Lenze U, Holzapfel BM, Rechl H, von Eisenhart-Rothe R, Gollwitzer H Tags: Orthopade Source Type: research
Selective ultrasound guided pectoral nerve targeting in breast augmentation: How to spare the brachial plexus cords?
AbstractSubpectoral breast augmentation surgery under regional anesthesia requires the selective neural blockade of the medial and lateral pectoral nerves to diminish postoperative pain syndromes. The purpose of this cadaver study is to demonstrate a reliable ultrasound guided approach to selectively target the pectoral nerves and their branches while sparing the brachial plexus cords. After evaluating the position and appearance of the pectoral nerves in 25 cadavers (50 sides), a portable ultrasound machine was used to guide the injection of 10 ml of 0.2% aqueous methylene blue solution in the pectoral region on both side...
Source: Clinical Anatomy - June 21, 2012 Category: Anatomy Authors: Jean Desroches, Ursula Grabs, Detlev Grabs Tags: Original Communication Source Type: research
EUS-guided biliary drainage for patients with malignant biliary obstruction with an indwelling duodenal stent (with videos)
Endoscopic retrograde cholangiography (ERC) is the method most commonly used for palliation of malignant biliary obstruction. Percutaneous and, rarely, surgical bypass are used after failed ERC. EUS-guided biliary drainage (EGBD) is an emerging less-invasive alternative after unsuccessful transpapillary biliary cannulation in patients with altered anatomy (eg, pancreaticoduodenectomy) and those with gastric outlet obstruction. EGBD can be performed entirely transhepatically or transduodenally without accessing the papilla or via rendezvous whereby the guidewire must pass through the papilla. Patients with gastric outlet ob...
Source: Gastrointestinal Endoscopy - June 21, 2012 Category: Gastroenterology Authors: Mouen A. Khashab, Larissa L. Fujii, Todd H. Baron, Marcia Irene Canto, Christopher J. Gostout, Bret T. Petersen, Patrick I. Okolo, Mark D. Topazian, Michael J. Levy Tags: Case Studies Source Type: research
The link between stress and feeding behaviour.
This article is part of a Special Issue entitled 'SI: Central Control of Food Intake'. PMID: 22710442 [PubMed - in process]
Source: Neuropharmacology - June 21, 2012 Category: Drugs & Pharmacology Authors: Maniam J, Morris MJ Tags: Neuropharmacology Source Type: research
Computational modeling of the human atrial anatomy and electrophysiology
Abstract This review article gives a comprehensive survey of the progress made in computational modeling of the human atria during the last 10 years. Modeling the anatomy has emerged from simple “peanut”-like structures to very detailed models including atrial wall and fiber direction. Electrophysiological models started with just two cellular models in 1998. Today, five models exist considering e.g. details of intracellular compartments and atrial heterogeneity. On the pathological side, modeling atrial remodeling and fibrotic tissue are the other important aspects. The bridge to data that are meas...
Source: Medical and Biological Engineering and Computing - June 21, 2012 Category: Biomedical Engineering Tags: Medical and Biological Engineering and Computing Source Type: research
Effects of exercise after focal cerebral cortex infarction on basal ganglion
Abstract Identification of functional molecules in the brain related to improvement of motor dysfunction after stroke will contribute to establish a new treatment strategy for stroke rehabilitation. Hence, monoamine changes in basal ganglion related to motor control were examined in groups with/without voluntary exercise after cerebral infarction. Cerebral infarction was produced by photothrombosis in rats. Voluntary exercise using a running wheel was initiated from 2 days after surgery. Motor performance was measured by the accelerated rotarod test. Monoamine concentrations in striatum were analyzed us...
Source: Neurological Sciences - June 21, 2012 Category: Neurology Tags: Neurological Sciences Source Type: research
Glucocorticoid Receptors are Localized to Dendritic Spines and Influence Local Actin Signaling
Abstract Glucocorticoids affect learning and memory but the cellular mechanisms involved are poorly understood. The present studies tested if the stress-responsive glucocorticoid receptor (GR) is present and regulated within dendritic spines, and influences local signaling to the actin cytoskeleton. In hippocampal field CA1, 13 % of synapses contained GR-immunoreactivity. Three-dimensional reconstructions of CA1 dendrites showed that GR aggregates are present in both spine heads and necks. Consonant with evidence that GRα mRNA associates with the translation regulator Fragile X Mental Retardation Prote...
Source: Molecular Neurobiology - June 21, 2012 Category: Neurology Tags: Molecular Neurobiology Source Type: research
Role of NF-κB activation in LPS-induced endothelial barrier breakdown
Abstract Endothelial barrier breakdown contributes to organ failure in sepsis. The key mechanism by which the potent sepsis inductor lipopolysaccharide (LPS) disrupts the endothelial barrier is controversial. Here, we tested the hypothesis that NF-κB activation is critically involved in endothelial barrier breakdown. Application of LPS to monolayers of porcine pulmonary artery endothelial cells (PAEC) and human dermal microvascular endothelial cells (HDMEC) induced a rapid and sustained activation of NF-κB as revealed by translocation of its subunit p65 into the nuclei in nuclear extraction assays and by i...
Source: Histochemistry and Cell Biology - June 21, 2012 Category: Biomedical Science Tags: Histochemistry and Cell Biology Source Type: research
Current and Future Instructional Methods and Influencing Factors in Anatomy Instruction in Physical Therapy and Medical Schools in the U.S.
Source: Journal of Allied Health - June 21, 2012 Category: Universities & Medical Training Authors: Gabard, Donald L.Lowe, Deborah L.Chang, Julia W. Tags: Research Articles Source Type: research
Computed tomographic lymphography predicts the difficulty of sentinel lymph node biopsy with dye.
CONCLUSIONS: Our study clearly demonstrates that the CT-LG findings of well-visualized LVs and SLNs predict the easy access to the stained LVs and SLNs. This information provides several advantages, including the fact that an easy SLNB case can be selected for a doctor with little experience in SLNB, and the volume of dye and/or length of massage can be changed for better identification of stained LVs and SLNs during SLNB. PMID: 22718426 [PubMed - as supplied by publisher]
Source: Breast Cancer - June 21, 2012 Category: Cancer & Oncology Authors: Yokohata K, Hattori M, Fujimoto T, Chikazawa N, Maeyama R, Yamanaka N, Kuroki H, Sasaki N, Kameoka N, Matoba N Tags: Breast Cancer Source Type: research
An anatomically driven anisotropic diffusion filtering method for 3D SPECT reconstruction.
In this study, we aim to reconstruct single-photon emission computed tomography images using anatomical information from magnetic resonance imaging as a priori knowledge about the activity distribution. The trade-off between anatomical and emission data is one of the main concerns for such studies. In this work, we propose an anatomically driven anisotropic diffusion filter (ADADF) as a penalized maximum likelihood expectation maximization optimization framework. The ADADF method has improved edge-preserving denoising characteristics compared to other smoothing penalty terms based on quadratic and non-quadratic functions. ...
Source: Physics in Medicine and Biology - June 21, 2012 Category: Physics Authors: Kazantsev D, Arridge SR, Pedemonte S, Bousse A, Erlandsson K, Hutton BF, Ourselin S Tags: Phys Med Biol Source Type: research
A method for energy window optimization for quantitative tasks that includes the effects of model-mismatch on bias: application to Y-90 bremsstrahlung SPECT imaging.
Abstract Quantitative Yttrium-90 ((90)Y) bremsstrahlung single photon emission computed tomography (SPECT) imaging has shown great potential to provide reliable estimates of (90)Y activity distribution for targeted radionuclide therapy dosimetry applications. One factor that potentially affects the reliability of the activity estimates is the choice of the acquisition energy window. In contrast to imaging conventional gamma photon emitters where the acquisition energy windows are usually placed around photopeaks, there has been great variation in the choice of the acquisition energy window for (90)Y imaging due to ...
Source: Physics in Medicine and Biology - June 21, 2012 Category: Physics Authors: Rong X, Du Y, Frey EC Tags: Phys Med Biol Source Type: research
Automatic bladder segmentation on CBCT for multiple plan ART of bladder cancer using a patient-specific bladder model.
Abstract In multiple plan adaptive radiotherapy (ART) strategies of bladder cancer, a library of plans corresponding to different bladder volumes is created based on images acquired in early treatment sessions. Subsequently, the plan for the smallest PTV safely covering the bladder on cone-beam CT (CBCT) is selected as the plan of the day. The aim of this study is to develop an automatic bladder segmentation approach suitable for CBCT scans and test its ability to select the appropriate plan from the library of plans for such an ART procedure. Twenty-three bladder cancer patients with a planning CT and on average 1...
Source: Physics in Medicine and Biology - June 21, 2012 Category: Physics Authors: Chai X, van Herk M, Betgen A, Hulshof M, Bel A Tags: Phys Med Biol Source Type: research
Facial Filler and Neurotoxin Complications
Facial plast Surg 2012; 28: 288-293DOI: 10.1055/s-0032-1312695Botulinum neuromodulators and injectable dermal fillers have become part of the armamentarium in the treatment of facial aging. Their successful use requires a fundamental knowledge of anatomy and physiology and a sound understanding of their risks and complications. Although neuromodulators and fillers continue to demonstrate a strong record of safety, several notable risks exist.[...]Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents | Abstract | CME online | Full text
Source: Facial Plastic Surgery - June 21, 2012 Category: Cosmetic Surgery Authors: Nettar, KartikMaas, Corey Source Type: research
Rhinoplasty and Bony Vault Complications
This article highlights possible complications of bony nasal vault surgery and their etiologies, appearances, and management.[...]Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:Table of contents | Abstract | CME online | Full text
Source: Facial Plastic Surgery - June 21, 2012 Category: Cosmetic Surgery Authors: Nassif, PaulKulbersh, Joanathan Source Type: research
Modification of a Bifurcated Stent Graft for Aortouniiliac Endovascular Aneurysm Repair in a Renal Transplant Patient
Conclusions. The AUI conversion from existing Gore excluder stent graft system is safe and should be considered when faced with challenging anatomy of a pelvic renal transplant, slender access, and contralateral iliac occlusion.
Source: Vascular and Endovascular Surgery - June 21, 2012 Category: Surgery Authors: Poon, H., Duddy, M. J., Tiwari, A., Hopkins, J. D. Tags: Endovascular Techniques Source Type: research
Endoscopic ablation of Barrett's neoplasia with a new focal radiofrequency device: initial experience with the Halo60
We report the first use of this device in 17 patients with either DBE or residual Barrett's esophagus after endoscopic resection of intramucosal adenocarcinoma.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Abstract | Full text
Source: Endoscopy - June 21, 2012 Category: Gastroenterology Authors: Allen, B.Kapoor, N.Willert, R.McEwan, H.Fullarton, G.Penman, I. Tags: Case report/series Source Type: research
The anatomy of osteoarthritic joint pain
AbstractThe anatomical understanding of the pain generators in osteoarthritis (OA) is incomplete and the teaching about these pain generators in medical school anatomy/histology courses is minimal. This review covers the nociceptive innervation of synovial joints for the purposes of teaching. Studies that discuss the presence of neuropeptides involved in pain, such as Substance P (SP) and calcitonin‐gene‐related peptide, are the focus of this review. Nociceptive free‐nerve endings and SP staining nerves are found in the accessory ligaments, synovium, subchondral bone, menisci, and periosteum. The vasculature may also...
Source: Clinical Anatomy - June 21, 2012 Category: Anatomy Authors: Kevin L. Witt, Joel A. Vilensky Tags: Medical Education Source Type: research
Influence of cartilage and menisci on the sagittal slope of the tibial plateaus
AbstractWe analyzed the magnetic resonance studies of the knee in 80 subjects, 45 men and 35 women with a mean age of 38.9 years, who showed no pathological condition of the joint. Using an imaging visualization software, the sagittal longitudinal axis of the tibia was identified. The angle between this axis and a line tangent to the bone profile of the tibial plateau (bone slope) and to the superior border of the menisci (meniscal slope) were calculated. Thickness of anterior and posterior portion of menisci and underlying cartilage were also measured. The bone slope averaged 8° and 7.7° on the medial and lateral sides,...
Source: Clinical Anatomy - June 21, 2012 Category: Anatomy Authors: Gianluca Cinotti, Pasquale Sessa, Giovanni Ragusa, Francesca Romana Ripani, Roberto Postacchini, Raffaele Masciangelo, Giuseppe Giannicola Tags: Original Communication Source Type: research
Transcatheter treatment of unroofed coronary sinus
AbstractUnroofed coronary sinus (coronary sinus‐type atrial septal defect) is a rare congenital anomaly resulting from imperfect development of left atrio‐venous fold. This malformation is not considered suitable for percutaneous treatment due to complex anatomy and risk of coronary sinus obstruction. This paper reports on the first successful treatment of partially unroofed coronary sinus by implantation of an Amplatzer® Septal Occluder device (AGA Medical Co., Golden Valley, MN, USA). In this patient, the malformation was deemed favourable for device closure due to the local anatomy and the association with persiste...
Source: Catheterization and Cardiovascular Interventions - June 21, 2012 Category: Cardiovascular & Thoracic Surgery Authors: Giuseppe Santoro, Gianpiero Gaio, Maria Giovanna Russo Tags: Case Report Source Type: research
Early clinical experience with a modified Amplatzer ductal Occluder for transcatheter arterial duct occlusion in infants and small children.
Conclusions:The new Amplatzer Ductal Occluder II AS achieves excellent ductal closure rates through low profile delivery systems in small infants and children with variable ductal anatomy. © 2012 Wiley Periodicals, Inc.
Source: Catheterization and Cardiovascular Interventions - June 21, 2012 Category: Cardiovascular & Thoracic Surgery Authors: Damien Kenny, Gareth J Morgan, James R Bentham, Neil Wilson, Robin Martin, AndrewW FRCP, Paul Oslizlok, Kevin P Walsh Tags: Original StudY Source Type: research