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Goal-directed haemodynamic therapy and gastrointestinal complications in major surgery: a meta-analysis of randomized controlled trialsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Postoperative gastrointestinal (GI) dysfunction is one of the most frequent complications in surgical patients. Most cases are associated with episodes of splanchnic hypoperfusion due to hypovolaemia or cardiac dysfunction. It has been suggested that perioperative haemodynamic goal-directed therapy (GDT) may reduce the incidence of these complications in cardiac surgery, and other surgery, but clear evidence is lacking. We have undertaken a meta-analysis of the effects of GDT on postoperative GI and liver complications. A systematic search, using MEDLINE, EMBASE, and The Cochrane Library databases, was performed. Sixteen r...
Source: British Journal of Anaesthesia - October 16, 2009 Category: Anesthesiology Authors: Giglio, M. T., Marucci, M., Testini, M., Brienza, N. Tags: Review Articles Source Type: journals

N-terminal pro-B-type natriuretic peptide levels and early outcome after cardiac surgery: a prospective cohort studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions NT-proBNP levels predict early outcome after cardiac surgery. Their prognostic utility is modest—but is independent of traditional indicators and conventional risk prediction scores.
Source: British Journal of Anaesthesia - October 16, 2009 Category: Anesthesiology Authors: Cuthbertson, B. H., Croal, B. L., Rae, D., Gibson, P. H., McNeilly, J. D., Jeffrey, R. R., Smith, W. C., Prescott, G. J., Buchan, K. G., El-Shafei, H., Gibson, G. A., Hillis, G. S. Tags: Cardiovascular Source Type: journals

Functional comparison of anaesthetic agents during myocardial ischaemia-reperfusion using pressure-volume loopsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions During ischaemia, all anaesthetics provide haemodynamic stability and preservation of LV contractility, whereas propofol and sevoflurane, but not desflurane, caused increased LV diastolic stiffness. Desflurane and sevoflurane provide superior cardioprotection compared with propofol.
Source: British Journal of Anaesthesia - October 16, 2009 Category: Anesthesiology Authors: Andrews, D. T., Royse, A. G., Royse, C. F. Tags: Cardiovascular Source Type: journals

A novel method of measuring the mental workload of anaesthetists during simulated practiceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions These findings confirm the importance of mental workload to the performance of anaesthetists, and suggest that raised mental workload is likely to be a common problem. Although further studies are required, the method described may provide a useful method for the measurement of the mental workload of anaesthetists.
Source: British Journal of Anaesthesia - October 16, 2009 Category: Anesthesiology Authors: Davis, D. H. J., Oliver, M., Byrne, A. J. Tags: Clinical Practice Source Type: journals

Comparison of four different display designs of a novel anaesthetic monitoring system, the 'integrated monitor of anaesthesia (IMATM)'Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions A mixed numerical–graphical display design appears to present the best results in terms of user reaction times, response accuracy, and performance index when detecting abnormal critical events.
Source: British Journal of Anaesthesia - October 16, 2009 Category: Anesthesiology Authors: Charabati, S., Bracco, D., Mathieu, P. A., Hemmerling, T. M. Tags: Clinical Practice Source Type: journals

Automated pulse pressure and stroke volume variations from radial artery: evaluation during major abdominal surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions PPVauto and SVVauto predict fluid responsiveness as accurately as off-line PPVref in patients with haemodynamic instability during major abdominal surgery.
Source: British Journal of Anaesthesia - October 16, 2009 Category: Anesthesiology Authors: Derichard, A., Robin, E., Tavernier, B., Costecalde, M., Fleyfel, M., Onimus, J., Lebuffe, G., Chambon, J.-P., Vallet, B. Tags: Clinical Practice Source Type: journals

Effect of anaesthetic technique on oestrogen receptor-negative breast cancer cell function in vitroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Serum from patients receiving propofol/paravertebral anaesthesia for breast cancer surgery inhibited proliferation, but not migration, of ER-MDA-MB-231 cells in vitro, to a greater extent than that from patients receiving sevoflurane/opioid anaesthesia–analgesia. This implies that anaesthetic technique alters the serum molecular milieu in ways that may affect breast cancer cell function, possibly by altering anaesthetic and opioid drug administration and resultant pain scores.
Source: British Journal of Anaesthesia - October 16, 2009 Category: Anesthesiology Authors: Deegan, C. A., Murray, D., Doran, P., Ecimovic, P., Moriarty, D. C., Buggy, D. J. Tags: Clinical Practice Source Type: journals

Arginine-vasopressin attenuates beneficial norepinephrine effect on jejunal mucosal tissue oxygenation during endotoxinaemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Both NE and NE+AVP improved global haemodynamics and systemic oxygen transport variables when compared with control animals in an acute endotoxic pig model. NE improved jejunal Po2muc at all dosages. NE effects were significantly blunted by simultaneous administration of AVP.
Source: British Journal of Anaesthesia - October 16, 2009 Category: Anesthesiology Authors: Maier, S., Hasibeder, W., Pajk, W., Hengl, C., Ulmer, H., Hausdorfer, H., Wurzinger, B., Knotzer, H. Tags: Critical Care Source Type: journals

Differential effects of halothane and sevoflurane on hypoxia-induced intracellular calcium transients of neonatal rat carotid body type I cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The actions of the agents in single cells reflect their known influence on human hypoxic ventilatory response, consistent with the notion that the cellular process underlies the whole-body effect. The responses to elevated extracellular potassium, which depolarizes the cell membrane, indicate that (in addition to molecular mechanisms previously proposed), voltage-activated calcium channels may also be involved in the anaesthetic effect.
Source: British Journal of Anaesthesia - October 16, 2009 Category: Anesthesiology Authors: Pandit, J. J., Buckler, K. J. Tags: Neurosciences And Neuroanaesthesia Source Type: journals

Apoptosis induction by different local anaesthetics in a neuroblastoma cell lineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions All commonly used local anaesthetics induce neuronal apoptosis in clinically used concentrations. The neurotoxicity correlates with lipid solubility and thus with the conduction blocking potency of the local anaesthetic, but is independent of the chemical class (ester/amide).
Source: British Journal of Anaesthesia - October 16, 2009 Category: Anesthesiology Authors: Werdehausen, R., Fazeli, S., Braun, S., Hermanns, H., Essmann, F., Hollmann, M. W., Bauer, I., Stevens, M. F. Tags: Neurosciences And Neuroanaesthesia Source Type: journals

Only tetracaine and not other local anaesthetics induce apoptosis in rat cortical astrocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Tetracaine induced apoptosis through ROS generation. Further studies focusing on the neurotoxicity of tetracaine are needed.
Source: British Journal of Anaesthesia - October 16, 2009 Category: Anesthesiology Authors: Lee, W. Y., Park, C. J., Shin, T. J., Yum, K. W., Yoon, T. G., Seo, K. S., Kim, H. J. Tags: Neurosciences And Neuroanaesthesia Source Type: journals

Drug Deemed Safe, Effective For Post-Surgical Pain In ChildrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Parents and physicians alike want to know the best options for pain relief for children, especially following painful surgical procedures. A new review from Sweden finds that diclofenac a medication that works for some adults also relieves acute pain in children. However, a U.S. researcher is not convinced that the review showed the alternate, costlier drug to be an improvement over standard pain-relief drugs, or that it is any safer for children.
Source: Pain / Anesthetics News From Medical News Today - October 16, 2009 Category: Anesthesiology Tags: Pain / Anesthetics Source Type: news

Pain-Related Placebo Effect Detected In Spinal CordEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Researchers in Germany found that when they treated volunteers with a placebo that they believed to be a painkiller, scans showed reduced signs of pain-related activity in their spinal cords. The study is the work of Dr Falk Eippert and colleagues, from the University Medical Center Hamburg-Eppendorf, one of the largest hospitals in Hamburg, and is published online in the 16 October issue of Science.
Source: Pain / Anesthetics News From Medical News Today - October 16, 2009 Category: Anesthesiology Tags: Pain / Anesthetics Source Type: news

For a Healthier Retirement, Work a LittleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: For a Healthier Retirement, Work a LittleCategory: Health NewsCreated: 10/16/2009 8:10:00 AMLast Editorial Review: 10/16/2009
Source: MedicineNet Chronic Pain General - October 16, 2009 Category: Anesthesiology Source Type: consumer

Naloxone-responsive acute dystonia and parkinsonism following general anaesthesiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report an acute, severe and generalised dystonic reaction in an otherwise healthy woman at emergence from general anaesthesia, dramatically reversed by the administration of naloxone, pointing to a potential role of the fentanyl and morphine that the patient had received. Recent literature on the mechanisms of abnormal movements induced by opioids are discussed. The severity of the reaction with usual doses of opioids, in a patient with no prior history of parkinsonism, led to further investigation that demonstrated the possibility of an enhanced susceptibility to opioids, involving a genetically determined abnormal fun...
Source: Anaesthesia - October 15, 2009 Category: Anesthesiology Authors: I. A. Iselin-Chaves, H. Grötzsch, M. Besson, P. R. Burkhard, G. L. Savoldelli Source Type: journals

[The implication of a direct antithrombne in the appearance of (serious) postoperative acute respiratory distress.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present the case of a 73-year-old man, operated on for paralyzing sciatica, who displayed acute postoperative respiratory distress and intra-alveolar haemorrhage following the administration of dabigatran etexilate, a new oral antithrombin used in the prevention of venous thromboembolism. This serious incident occurred in a patient who had a 20-year history of chronic thrombocytopenia (platelet level at 100G/l) and a heparin-induced thrombocytopenia and in whom no other aetiology was found (tuberculosis, pneumorenal syndrome, etc.). The postoperative prevention of thromboembolic events in a patient with high risk bleedi...
Source: Annales Francaises d'Anesthesie et de Reanimation - October 15, 2009 Category: Anesthesiology Authors: Hanf W, Duntze J, Hida H, Blanc Q, Reynaud C Tags: Ann Fr Anesth Reanim Source Type: journals

Correlation and agreement between the bispectral index vs. state entropy during hypothermic cardio-pulmonary bypassEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The bispectral index (BIS) and spectral entropy enable monitoring the depth of anaesthesia. Mild hypothermia has been shown to affect the ability of electroencephalography monitors to reflect the anaesthetic drug effect. The purpose of this study was to investigate the effect of hypothermia during a cardio-pulmonary bypass on the correlation and agreement between the BIS and entropy variables compared with normothermic conditions. This prospective clinical study included coronary artery bypass grafting patients (n=25) evaluating correlation and agreement (Bland[ndash]Altman analysis) between the BIS and both spectral and r...
Source: Acta Anaesthesiologica Scandinavica - October 14, 2009 Category: Anesthesiology Authors: P. MEYBOHM, M. GRUENEWALD, J. HÖCKER, J. RENNER, J.-T. GRAESNER, C. ILIES, J. SCHOLZ, B. BEIN Source Type: journals

Persistent sensory dysfunction in pain-free herniotomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Persistent post-herniotomy pain may be a neuropathic pain state based on the finding of a persistent sensory dysfunction. However, detailed information on the normal distribution of sensory function in pain-free post-herniotomy patients hinders identification of exact pathogenic mechanisms. Therefore, we aimed to establish normative data on sensory function in pain-free patients >1 year after a groin herniotomy. Sensory thresholds were assessed in 40 pain-free patients by a standardized quantitative sensory testing (QST). Secondary endpoints included comparison of sensory function between the operated and the naïve side, ...
Source: Acta Anaesthesiologica Scandinavica - October 14, 2009 Category: Anesthesiology Authors: E. K. AASVANG, H. KEHLET Source Type: journals

Pharmacokinetics after an intravenous single dose of the opioid ketobemidone in childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ketobemidone is often used as an alternative to morphine in children in the Scandinavian countries. The aim of this clinical trial was to explore the pharmacokinetics of ketobemidone in children because these properties have not been reported previously. Thirty children, newborn to 10 years, scheduled for elective surgery were included in the trial. Ketobemidone hydrochloride was administered as a single intravenous bolus dose and ketobemidone and norketobemidone concentrations were measured by LC-MS over 8 h. Pharmacokinetic parameters were determined using compartmental methods. Six children were excluded from pharmacoki...
Source: Acta Anaesthesiologica Scandinavica - October 14, 2009 Category: Anesthesiology Authors: S. LUNDEBERG, N. STEPHANSON, P. LAFOLIE, G. L. OLSSON, C.-O. STILLER, S. EKSBORG Source Type: journals

Knowledge of residual curarization: an Italian surveyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The use of neuromuscular blocking agents (NMBAs) is widespread in anesthetic practice; little is known about the current use of these drugs in Italy. This survey was conducted to obtain information about the most commonly used clinical tests and the train-of-four (TOF) ratios that are considered as being reliable for assessing recovery from neuromuscular blockade at the end of anesthesia and the estimated occurrence rates of post-operative paralysis in Italian hospitals. The questionnaire was given to Italian anesthesiologists attending the 62nd National Congress of the Italian Society of Anesthesia, Analgesia and Intensiv...
Source: Acta Anaesthesiologica Scandinavica - October 14, 2009 Category: Anesthesiology Authors: P. DI MARCO, G. DELLA ROCCA, F. IANNUCCELLI, L. POMPEI, C. REALE, P. PIETROPAOLI Source Type: journals

Neurolytic phenol blockade of the obturator nerve for severe adductor spasticityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we present the 3-month follow-up results of a retrospective analysis of obturator nerve (ON) phenol neurolysis performed between 2000 and 2007 in patients with adductor spasticity. The study was performed by retrospective investigation of the clinical follow-up results of 80 ON phenol treatments in 62 patients. Neurolysis using 5[ndash]10 ml 6% phenol was applied with the guidance of fluoroscopy and a peripheral nerve stimulator. Pain, spasticity and hygiene were evaluated and the hip abduction range of motion (ROM) was measured at the end of the first week and in the first, second and third months following...
Source: Acta Anaesthesiologica Scandinavica - October 14, 2009 Category: Anesthesiology Authors: T. AKKAYA, E. UNLU, A. ALPTEKIN, H. I. GUMUS, E. UMAY, A. CAKCI Source Type: journals

Unilateral paravertebral block: an alternative to conventional spinal anaesthesia for inguinal hernia repairEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Inguinal herniorrhaphy can be successfully performed using general, regional or local anaesthesia. Paravertebral block (PVB) has been used for unilateral procedures such as thoracotomy, breast surgery, chest wall trauma, hernia repair or renal surgery. We compared unilateral lumbar PVB with conventional spinal anaesthesia (SA) in 60 consenting ASA I and II males aged 18[ndash]65 years, scheduled for unilateral inguinal hernia repair. Patients were randomly assigned into two groups, P (n=30) or S (n=30) to receive either PVB or SA, respectively. Two patients (7%) in group P had to be converted to general anaesthesia due to ...
Source: Acta Anaesthesiologica Scandinavica - October 14, 2009 Category: Anesthesiology Authors: P. BHATTACHARYA, M. C. MANDAL, S. MUKHOPADHYAY, S. DAS, P. P. PAL, S. R. BASU Source Type: journals

Xenon and isoflurane improved biventricular function during right ventricular ischemia and reperfusionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although anesthetics have some cardioprotective properties, these benefits are often counterbalanced by their negative inotropic effects. Xenon, on the other hand, does not influence myocardial contractility. Thus, xenon may be a superior treatment for the maintenance of global hemodynamics, especially during right ventricular ischemia, which is generally characterized by a high acute complication rate. The effects of 70 vol% xenon and 0.9 vol% isoflurane on biventricular function were assessed in a porcine model (n=36) using the conductance catheter technique, and the expression of the type B natriuretic peptide (BNP) gen...
Source: Acta Anaesthesiologica Scandinavica - October 14, 2009 Category: Anesthesiology Authors: M. HEIN, A. B. ROEHL, J. H. BAUMERT, C. BLEILEVENS, S. FISCHER, P. STEENDIJK, R. ROSSAINT Source Type: journals

Real-time ultrasound-guided spinal anesthesia in patients with a challenging spinal anatomy: two case reportsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe two patients with an abnormal spinal anatomy in whom ultrasound-assisted spinal anesthesia was unsuccessful. Successful dural puncture was subsequently achieved using a technique of real-time ultrasound-guided spinal anesthesia. This may be a useful option in patients in whom landmark-guided and ultrasound-assisted techniques have failed.
Source: Acta Anaesthesiologica Scandinavica - October 14, 2009 Category: Anesthesiology Authors: K. J. CHIN, V. W. S. CHAN, R. RAMLOGAN, A. PERLAS Source Type: journals

Validation and clinical feasibility of nitrogen washin/washout functional residual capacity measurements in childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study validated the algorithm in a pediatric lung model and investigated the stability and feasibility in a pediatric peri-operative and intensive care setting. The lung model was ventilated in combinations of ventilatory modes, CO2 production, model FRC and respiratory rates. Sixteen children from 10 days to 5 years were studied peri-operatively with controlled ventilation using a Mapleson D system and in the intensive care unit using a Servo-i ventilator in a supported spontaneous mode. FRC was measured during stable metabolic, respiratory and circulatory periods at positive end expiratory pressure of 3[ndash]4 and ...
Source: Acta Anaesthesiologica Scandinavica - October 14, 2009 Category: Anesthesiology Authors: C. OLEGÅRD, S. SØNDERGAARD, J. PÅLSSON, S. LUNDIN, O. STENQVIST Source Type: journals

Pain Following Battlefield Injury and Evacuation: A Survey of 110 Casualties from the Wars in Iraq and AfghanistanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Our findings underscore the value of early aggressive pain management after major combat injuries. Increased pain was associated with increased anxiety, distress, and worry during transport, suggesting the need for psychological management along with analgesia. Regional anesthesia techniques while at LRMC contributed to better pain outcomes.
Source: Pain Medicine - October 14, 2009 Category: Anesthesiology Authors: Chester C. Buckenmaier III, Christine Rupprecht, Geselle McKnight, Brian McMillan, Ronald L. White, Rollin M. Gallagher, Rosemary Polomano Source Type: journals

NICE consults on draft guidance on pharmacological management of neuropathic painEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: NICE Area: News NICE has issued for consultation from 14th October 2009 to 11th November 2009, its draft guidance on the pharmacological management of neuropathic pain.
Source: NeLM - Pain control - October 14, 2009 Category: Anesthesiology Source Type: organizations

Single dose oral tenoxicam for acute postoperative pain in adultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Cochrane Library Area: Evidence > Drug Specific Reviews Background Tenoxicam is a non-steroidal anti-inflammatory drug (NSAID) licensed for use in rheumatic disease and other musculoskeletal disorders in the UK, and is widely available in other countries worldwide. This review sought to evaluate the efficacy and safety of oral tenoxicam in acute postoperative pain, using clinical studies of patients with established pain, and with outcomes measured primarily over 6 hours using standard methods. This type of study has been used for many decades to establish that drugs have analgesic properties.   Objective...
Source: NeLM - Pain control - October 14, 2009 Category: Anesthesiology Source Type: organizations

[Barotrauma by Venturi effect during apnea testing for the determination of brain death. Should it change the terms of application of this test?]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The clinical diagnosis of brain death is based on three clinical criteria, one of them being the abolition of the spontaneous breathing shown by an apnoea testing [1,2]. During this manoeuvre, oxygen is administered by intratracheal way through oxygen supply tubing inserted into the endotracheal tube. Few cases of barotrauma with tension pneumothorax during this test have been described in the literature bringing to the loss of potential donor or grafts for transplantation. The authors report a new case of tension pneumothorax occurred during an apnoea testing despite the precautionary measures necessary to prevent suc...
Source: Annales Francaises d'Anesthesie et de Reanimation - October 14, 2009 Category: Anesthesiology Authors: Cros J, Pichon N, Dugard A, Vignon P, François B Tags: Ann Fr Anesth Reanim Source Type: journals

Could The Hot Stuff In Chili Peppers Ease Your Tingling Nerve Pain?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Millions of people suffer peripheral pain and other troubling sensations accompanying diseases as varied as diabetes, AIDS, shingles and arthritis. Cancer patients also often suffer these so-called peripheral neuropathies because of their therapies. Peripheral neuropathies include disorders of a nerve or nerves outside the brain and spinal cord; they can precipitate tingling, numbness, weakness, burning pain and other unwelcome sensations.
Source: Pain / Anesthetics News From Medical News Today - October 14, 2009 Category: Anesthesiology Tags: Pain / Anesthetics Source Type: news

Health Tip: Manage Pain Without DrugsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: Health Tip: Manage Pain Without DrugsCategory: Health NewsCreated: 10/14/2009 8:10:00 AMLast Editorial Review: 10/14/2009
Source: MedicineNet Chronic Pain General - October 14, 2009 Category: Anesthesiology Source Type: consumer

The effect of intrathecal fentanyl on Cerebral State Index-guided sedation during spinal anaesthesia*Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, adding intrathecal fentanyl 25 [mu]g during spinal anaesthesia significantly reduced the dose of propofol required for sedation and prolonged the subsequent recovery time.
Source: Anaesthesia - October 13, 2009 Category: Anesthesiology Authors: J. Y. Kim, K. B. Kim, C. S. Shin, S. H. Ha, M. K. Kim, J. S. Lee Source Type: journals

[Diagnosis, therapy and secondary prophylaxis of acute pulmonary embolism : Presentation of and commentary on the new ESC 2008 guidelines.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Acute venous thromboembolism is a common cardiovascular emergency. Acute pulmonary embolism (PE) is present in one third of these patients. With an average lethality rate of 11% within the first two weeks following diagnosis, approximately 40,000 patients in Germany die annually as a result of PE; therefore, their diagnosis and therapy is of particular importance. For this reason, the European Society of Cardiology published guidelines on diagnosis and therapy in 2000. The current article presents and discusses the points as updated and extended in the 2008 version of the guidelines, including: (1) initial risk stratif...
Source: Der Anaesthesist - October 13, 2009 Category: Anesthesiology Authors: Walther A, Schellhaaß A, Böttiger BW, Konstantinides S Tags: Anaesthesist Source Type: journals

[Simulation-based anaesthesia crisis resource management training : Results of a survey on learning success.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Well-staged and realistic simulation is associated with better learning outcomes. It may be important to take gender aspects into account in ACRM training. PMID: 19823783 [PubMed - as supplied by publisher]
Source: Der Anaesthesist - October 13, 2009 Category: Anesthesiology Authors: Schröder T, V Heymann CH, Ortwein H, Rau J, Wernecke KD, Spies C Tags: Anaesthesist Source Type: journals

[New oral anticoagulants : Consequences for perioperative coagulation diagnostics and therapy.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dabigatranetexilate and rivaroxaban were approved for prevention of thromboembolic events after orthopedic surgery in 2008. Dabigatran is a direct inhibitor of thrombin and rivaroxaban of factor Xa. Inhibition is reversible and the duration of action is predictable. Both drugs considerably influence the global tests of coagulation thus making postoperative coagulation monitoring more difficult. In order to keep the interaction as low as possible blood samples for assessment of the thromboplastin time (PT) and the partial thromboplastin time (PTT) should be taken immediately before the next drug administration. Blood sa...
Source: Der Anaesthesist - October 13, 2009 Category: Anesthesiology Authors: Heindl B, Spannagl M Tags: Anaesthesist Source Type: journals

[Perioperative management of patients with coronary stents in non-cardiac surgery.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In patients with coronary stents scheduled for surgery the question arises whether and how antiplatelet therapy should be continued. Risks of perioperative bleeding and of acute stent thrombosis have to be considered simultaneously. The bleeding risk depends primarily on the kind of surgery and on patient comorbidity. The risk of stent thrombosis is increased in these patients due to the thrombogenic surface of the stents. The main determinants are hereby the time duration after stent implantation, the kind of the stent [uncoated (bare-metal stent, BMS) or coated (drug-eluting stent, DES)], as well as angiographic and ...
Source: Der Anaesthesist - October 13, 2009 Category: Anesthesiology Authors: Jámbor C, Spannagl M, Zwissler B Tags: Anaesthesist Source Type: journals

[Perioperative management of patients with coronary stents undergoing non-cardiac surgery : Better to accept loss of blood than a cardiac infarct?]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19823780 [PubMed - as supplied by publisher]
Source: Der Anaesthesist - October 13, 2009 Category: Anesthesiology Authors: Leschke M Tags: Anaesthesist Source Type: journals

[Mesenteric ischaemia related to peripartum cardiomyopathy.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19836190 [PubMed - as supplied by publisher]
Source: Annales Francaises d'Anesthesie et de Reanimation - October 13, 2009 Category: Anesthesiology Authors: Carrières PA, Brunel E, Georges B, Fourcade O Tags: Ann Fr Anesth Reanim Source Type: journals

[Hyponatremic coma induced by desmopressin infusion in a woman with von Willebrand's disease.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19836189 [PubMed - as supplied by publisher]
Source: Annales Francaises d'Anesthesie et de Reanimation - October 13, 2009 Category: Anesthesiology Authors: Brillouet-Banchereau AC, Winnock S, Maurette P Tags: Ann Fr Anesth Reanim Source Type: journals

FDA Warns Illegal Codeine MakersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
WASHINGTON (MedPage Today) -- The FDA issued a strict warning to four drug manufacturers today: stop making unapproved and illegal codeine sulfate tablets.
Source: MedPage Today Pain Management - October 13, 2009 Category: Anesthesiology Source Type: news

The fear-avoidance model of pain: We are not there yet. Comment on Wideman et al. “A prospective sequential analysis of the fear-avoidance model of pain” [Pain, 2009] and Nicholas “First things first: reduction in catastrophizing before fear of movement” [Pain, 2009]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Catastrophic interpretations of pain as a signal of impending threat usually elicits fear, and escape or avoidance behavior. According to the fear-avoidance (FA) model these behaviors may initially be adaptive, but they paradoxically worsen the situation when engaged in later on. Avoidance behavior may fuel pain, disability and depression. A particular strength of the FA model is that it generates testable hypotheses about the association amongst its constituent elements. Although correlational studies have accumulated, yet few studies have used prospective designs.
Source: Pain - October 13, 2009 Category: Anesthesiology Authors: Johan W.S. Vlaeyen, Geert Crombez, Steven J. Linton Tags: Letters to the Editor Source Type: journals

Editorial listEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Pain - October 13, 2009 Category: Anesthesiology Source Type: journals

Instructions to authorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Pain - October 13, 2009 Category: Anesthesiology Source Type: journals

Effects Of Aspirin And Folic Acid On Inflammation Markers For Colorectal AdenomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Unexpectedly, inflammation markers do not appear to be involved with the chemopreventative effect of aspirin on colorectal adenomas, according to a brief communication published online October 12 in the Journal of the National Cancer Institute. Aspirin has been shown to prevent the recurrence of colorectal polyps, but it's not clear how it works.
Source: Pain / Anesthetics News From Medical News Today - October 13, 2009 Category: Anesthesiology Tags: Colorectal Cancer Source Type: news

propoxyphene, Darvon, Darvon-N, DoleneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: propoxyphene, Darvon, Darvon-N, DoleneCategory: MedicationsCreated: 3/26/1998 2:30:00 PMLast Editorial Review: 10/13/2009
Source: MedicineNet Chronic Pain General - October 13, 2009 Category: Anesthesiology Source Type: consumer

Pharmacokinetic–pharmacodynamic modeling of the hypotensive effect of remifentanil in infants undergoing cranioplastyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Remifentanil is effective in causing hypotension. The final model predicts that a steady state remifentanil concentration of 14 ng·ml[minus]1 would typically achieve a 30% decrease in MAP.
Source: Pediatric Anesthesia - October 12, 2009 Category: Anesthesiology Authors: JOSEPH F. STANDING, GREGORY B. HAMMER, WAI JOHNN SAM, DAVID R. DROVER Source Type: journals

A bench study of ventilation via two self-assembled jet devices and the Oxygen Flow Modulator in simulated upper airway obstructionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In managing an obstructed upper airway, an emergency transtracheal ventilation device needs to function as a bidirectional airway, allowing both insufflation of oxygen and egress of gas. The aim of the present study was to determine the capability of two self-assembled, three-way stopcock based jet devices and the Oxygen Flow Modulator to function as a bidirectional airway in conjunction with a small lumen catheter. For each device the effective pressures at the catheter's tip during the expiratory phase and the achievable minute volumes were determined in a laboratory set-up. Using the three-way stopcock based jet devices...
Source: Anaesthesia - October 12, 2009 Category: Anesthesiology Authors: A. E. W. Hamaekers, P. A. J. Borg, D. Enk Source Type: journals

Nycomed launches Instanyl® (intranasal fentanyl spray) for relief of breakthrough cancer painEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Nycomed Area: News Nycomed has launched an intranasal fentanyl spray (Instanyl) for the management of breakthrough pain in adults already receiving maintenance opioid therapy for chronic cancer pain.   The Summary of Product Characteristics defines patients receiving maintenance opioid therapy as those who are taking at least 60 mg of oral morphine daily, at least 25 micrograms of transdermal fentanyl per hour, at least 30 mg oxycodone daily, at least 8 mg of oral hydromorphone daily or an equianalgesic dose of another opioid for a week or longer.   The product is available as Instanyl® 50, 100 ...
Source: NeLM - Pain control - October 12, 2009 Category: Anesthesiology Source Type: organizations

Pregabalin for acute and chronic pain in adultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Cochrane Library Area: Evidence > Drug Specific Reviews Background Antiepileptic drugs have been used in pain management since the 1960s. Pregabalin is a recently developed antiepileptic drug also used in management of chronic neuropathic pain conditions.   Objectives To assess analgesic efficacy and associated adverse events of pregabalin in acute and chronic pain.   Search strategy We searched MEDLINE, EMBASE, and CENTRAL to May 2009 for randomised controlled trials (RCTs). Additional studies were identified from the reference lists of retrieved papers and on-line clinical trial databases. &n...
Source: NeLM - Pain control - October 12, 2009 Category: Anesthesiology Source Type: organizations

misoprostol, CytotecEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: misoprostol, CytotecCategory: MedicationsCreated: 12/31/1997Last Editorial Review: 10/12/2009
Source: MedicineNet Chronic Pain General - October 12, 2009 Category: Anesthesiology Source Type: consumer

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