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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 9.

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A cost-effective screening method for preoperative hyperglycemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: This preoperative blood glucose screening test was implemented at a cost of approximately one-tenth of current methods. PMID: 19843800 [PubMed - in process]
Source: Anesthesia and Analgesia - October 23, 2009 Category: Anesthesiology Authors: Grek S, Gravenstein N, Morey TE, Rice MJ Tags: Anesth Analg Source Type: journals

Mild hypothermia has no long-term impact on postischemic neurogenesis in rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Neither intraischemic nor postischemic hypothermia affected the ischemia-induced increase in endogenous neurogenesis. Intraischemic hypothermia reduced hippocampal damage, whereas postischemic hypothermia as applied here did not prevent formation of histopathological injury. This indicates that, 28 days after cerebral ischemia, postischemic neurogenesis is not significantly increased by mild peri-ischemic hypothermia and not affected by the severity of histopathological damage. PMID: 19843801 [PubMed - in process]
Source: Anesthesia and Analgesia - October 23, 2009 Category: Anesthesiology Authors: Lasarzik I, Winkelheide U, Thal SC, Benz N, Lörscher M, Jahn-Eimermacher A, Werner C, Engelhard K Tags: Anesth Analg Source Type: journals

When drugs disappear from the patient: elimination of intravenous medication by hemodiafiltration.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Twenty-three hours after heart transplantation, life-threatening acute right heart failure was diagnosed in a patient requiring continuous venovenous hemodiafiltration (CVVHDF). Increasing doses of catecholamines, sedatives, and muscle relaxants administered through a central venous catheter were ineffective. However, a bolus of epinephrine injected through an alternative catheter provoked a hypertensive crisis. Thus, interference with the central venous infusion by the dialysis catheter was suspected. The catheters were changed, and hemodynamics stabilized at lower catecholamine doses. When the effects of IV drugs are...
Source: Anesthesia and Analgesia - October 23, 2009 Category: Anesthesiology Authors: Stricker KH, Takala J, Hullin R, Ganter CC Tags: Anesth Analg Source Type: journals

A comparison of gabapentin and ketamine in acute and chronic pain after hysterectomy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Gabapentin and ketamine are similar in improving early pain control and in decreasing opioid consumption; however, gabapentin also prevented chronic pain in the first 6 postoperative months. PMID: 19843803 [PubMed - in process]
Source: Anesthesia and Analgesia - October 23, 2009 Category: Anesthesiology Authors: Sen H, Sizlan A, Yanarates O, Emirkadi H, Ozkan S, Dagli G, Turan A Tags: Anesth Analg Source Type: journals

Increase in quality, but not quantity, of clinical trials in acute pain: 1992 versus 2007.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The annual number of published clinical trials in acute postoperative pain in adults has changed little in 15 yr and, as a fraction of all clinical trials published in the six highest impact journals in anesthesiology, has actually decreased from 16% (95% confidence interval: 12-20) to 11% (95% confidence interval: 9-15). However, the methodological quality of reports has improved, with explicit statements on power analysis, allocation concealment, and specification of primary end points exceeding 90% of reports in 2007. There has been a shift in hypothesis interests away from neuraxial analgesia and toward multimodal ...
Source: Anesthesia and Analgesia - October 23, 2009 Category: Anesthesiology Authors: Reeves MD Tags: Anesth Analg Source Type: journals

The effect of a thoracic spinal block on fos expression in the lumbar spinal cord of the rat induced by a noxious electrical stimulus at the hindpaw.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The increase in Fos-IR in Lamina V may have resulted from the interruption of a pain-modulating descending mechanism from the brain. A known modulating descending mechanism is the serotonergic system, controlled by the periaqueductal gray. This system inhibits the neurons in the superficial laminae. Another nonserotonergic system originates in the anterior pretectal nucleus. The latter facilitates neurons in the superficial laminae, while neurons in Lamina V are inhibited. We conclude that both systems are probably involved in the observed effects of the peripheral noxious stimulation given in the present mode...
Source: Anesthesia and Analgesia - October 23, 2009 Category: Anesthesiology Authors: Giele JL, Nabers AF, Veening JG, van Egmond J, Vissers KC Tags: Anesth Analg Source Type: journals

The effects of electroacupuncture on TH1/TH2 cytokine mRNA expression and mitogen-activated protein kinase signaling pathways in the splenic T cells of traumatized rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: EA regulates a balance between Th1 and Th2 cytokines at protein and mRNA levels in splenic T cells, and, at least in part, involves the signaling pathways of ERK1/2, p38, NF-kappaB, and AP-1. The findings suggest that EA may improve immune suppression after surgical trauma. PMID: 19843806 [PubMed - in process]
Source: Anesthesia and Analgesia - October 23, 2009 Category: Anesthesiology Authors: Wang K, Wu H, Wang G, Li M, Zhang Z, Gu G Tags: Anesth Analg Source Type: journals

The effects of ultrasound guidance and neurostimulation on the minimum effective anesthetic volume of mepivacaine 1.5% required to block the sciatic nerve using the subgluteal approach.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: US provided a 37% reduction in the MEAV(50) of 1.5% mepivacaine required to block the sciatic nerve compared with NS. PMID: 19843807 [PubMed - in process]
Source: Anesthesia and Analgesia - October 23, 2009 Category: Anesthesiology Authors: Danelli G, Ghisi D, Fanelli A, Ortu A, Moschini E, Berti M, Ziegler S, Fanelli G Tags: Anesth Analg Source Type: journals

An ultra-low dose of naloxone added to lidocaine or lidocaine-fentanyl mixture prolongs axillary brachial plexus blockade.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The addition of an ultra-low dose of naloxone to lidocaine 1.5% solution with or without fentanyl solution in axillary brachial plexus block prolongs the time to first postoperative pain and motor blockade but also lengthens the onset time. PMID: 19843808 [PubMed - in process]
Source: Anesthesia and Analgesia - October 23, 2009 Category: Anesthesiology Authors: Movafegh A, Nouralishahi B, Sadeghi M, Nabavian O Tags: Anesth Analg Source Type: journals

Ropivacaine spinal anesthesia is not antagonized by ondansetron pretreatment.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Ondansetron had no effect on the subarachnoid sensory or motor block produced by ropivacaine. PMID: 19843809 [PubMed - in process]
Source: Anesthesia and Analgesia - October 23, 2009 Category: Anesthesiology Authors: Paraskeva A, Chatziara V, Siafaka I, Zotou M, Fassoulaki A Tags: Anesth Analg Source Type: journals

Central sensory-motor deficit after uneventful single-dose spinal morphine administration in a patient with preexisting migraine headaches.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a persisting central neurological deficit after single-dose spinal administration of 400 mug of morphine in a patient with no previous neurological condition. Hemiplegic migraine was thought to be present when the patient emerged from anesthesia. Weakness in the left quadriceps and saddle anesthesia of the perineum and urinary retention of central origin remained present 3 yr later. Over the 3 postoperative years, the patient was admitted to a neurological unit 5 times because of acute headache associated with complete left-sided hemiplegia. These symptoms resolved within 24 h of onset. Hemiplegic migraine was th...
Source: Anesthesia and Analgesia - October 23, 2009 Category: Anesthesiology Authors: Lentschener C, Dousset B, Zuber M, Ozier Y Tags: Anesth Analg Source Type: journals

Ultrasound-guided paravertebral block using an intercostal approach.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe an ultrasound-guided technique of continuous bilateral paravertebral block using an intercostal approach in 12 patients undergoing elective abdominal surgery. Postoperatively, each of the patient's paravertebral catheters was bolused with 10 mL lidocaine (15 mg/mL), and each of the patient's catheters was infused with 0.2% ropivacaine at 10 mL/h. Using a pinprick test, the median number of dermatomes blocked after the initial bolus was 5 (interquartile range, 4-6), and 23 of 24 catheters produced a local anesthetic block. The median verbal pain score on postoperative day 1 was 5.5 (interquartile range, 3.5-6), ...
Source: Anesthesia and Analgesia - October 23, 2009 Category: Anesthesiology Authors: Ben-Ari A, Moreno M, Chelly JE, Bigeleisen PE Tags: Anesth Analg Source Type: journals

Some unanswered questions about temperature management.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19843812 [PubMed - in process]
Source: Anesthesia and Analgesia - October 23, 2009 Category: Anesthesiology Authors: Roth JV Tags: Anesth Analg Source Type: journals

Transient neurologic symptoms after spinal anesthesia with lidocaine versus other local anesthetics.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19843813 [PubMed - in process]
Source: Anesthesia and Analgesia - October 23, 2009 Category: Anesthesiology Authors: Zaric D, Pace NL Tags: Anesth Analg Source Type: journals

Incentive spirometry for prevention of postoperative pulmonary complications in upper abdominal surgery.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19843814 [PubMed - in process]
Source: Anesthesia and Analgesia - October 23, 2009 Category: Anesthesiology Authors: Guimarães MM, El Dib RP, Smith AF, Matos D, Gomes B Tags: Anesth Analg Source Type: journals

Are normal echocardiographic values obtained by transthoracic echocardiography in awake patients suitable for evaluation of cardiac function in anesthetized and mechanically ventilated patients?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19843815 [PubMed - in process]
Source: Anesthesia and Analgesia - October 23, 2009 Category: Anesthesiology Authors: Michaux I, Filipovic M, Seeberger M, Skarvan K Tags: Anesth Analg Source Type: journals

Bowel surgery and multimodal analgesia: same game, new team?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19843816 [PubMed - in process]
Source: Anesthesia and Analgesia - October 23, 2009 Category: Anesthesiology Authors: Eipe N, Penning J Tags: Anesth Analg Source Type: journals

Recurrence of local anesthetic cardiac toxicity or hypokalemia?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19843817 [PubMed - in process]
Source: Anesthesia and Analgesia - October 23, 2009 Category: Anesthesiology Authors: Krishnan S, Raw R Tags: Anesth Analg Source Type: journals

Quality oversight needed for intraoperative autologous blood recovery and readministration.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19843818 [PubMed - in process]
Source: Anesthesia and Analgesia - October 23, 2009 Category: Anesthesiology Authors: Waters JH Tags: Anesth Analg Source Type: journals

Blood Infection Diagnosis by 16S rDNA Broad-Spectrum Polymerase Chain Reaction: The Relationship Between Antibiotic Treatment and Bacterial DNA Load.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19843819 [PubMed - in process]
Source: Anesthesia and Analgesia - October 23, 2009 Category: Anesthesiology Authors: Sakka SG, Kochem AJ, Disqué C, Wellinghausen N Tags: Anesth Analg Source Type: journals

Overcoming dose-counting mechanisms on metered-dose inhalers for urgent treatment in the operating room.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19843820 [PubMed - in process]
Source: Anesthesia and Analgesia - October 23, 2009 Category: Anesthesiology Authors: Templeton LB, Galyon SW, Smith TE Tags: Anesth Analg Source Type: journals

Continuous transversus abdominis plane block for renal transplant recipients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19843821 [PubMed - in process]
Source: Anesthesia and Analgesia - October 23, 2009 Category: Anesthesiology Authors: Jankovic ZB, Pollard SG, Nachiappan MM Tags: Anesth Analg Source Type: journals

A Practice of Anesthesia for Infants and Children, 4th ed.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19843822 [PubMed - in process]
Source: Anesthesia and Analgesia - October 23, 2009 Category: Anesthesiology Authors: Mann DG, Watcha MM Tags: Anesth Analg Source Type: journals

Report of asian society of paediatric anaesthesiologists 2009 meeting in ho chi minh city, Vietnam.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19843823 [PubMed - in process]
Source: Anesthesia and Analgesia - October 23, 2009 Category: Anesthesiology Authors: Yamashita M Tags: Anesth Analg Source Type: journals

A practical approach to pediatric anesthesia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19843824 [PubMed - in process]
Source: Anesthesia and Analgesia - October 23, 2009 Category: Anesthesiology Authors: Tuchman JB Tags: Anesth Analg Source Type: journals

Alveolar recruitment strategy and PEEP improve oxygenation, dynamic compliance of respiratory system and end-expiratory lung volume in pediatric patients undergoing cardiac surgery for congenital heart diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: An alveolar recruitment strategy with relative high PEEP significantly improves Crs, oxygenation, PaCO2[ndash] PETCO2 difference, and EELV in pediatric patients undergoing cardiac surgery for congenital heart disease.
Source: Pediatric Anesthesia - October 23, 2009 Category: Anesthesiology Authors: THIERRY V. SCOHY, IDO G. BIKKER, JAN HOFLAND, PETER L. de JONG, AD J.J.C. BOGERS, DIEDERIK GOMMERS Source Type: journals

An assessment of the validity of SOFA score based triage in H1N1 critically ill patients during an influenza pandemicEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sequential Organ Failure Assessment (SOFA) score based triage of influenza A H1N1 critically ill patients has been proposed for surge capacity management as a guide for clinical decision making. We conducted a retrospective records review and SOFA scoring of critically ill patients with influenza A H1N1 in a mixed medical-surgical intensive care unit in an urban hospital. Eight critically ill patients with influenza A H1N1 were admitted to the intensive care unit. Their mean (range) age was 39 (26[ndash]52) years with a length of stay of 11 (3[ndash]17) days. All patients met SOFA score based triage admission criteria with...
Source: Anaesthesia - October 23, 2009 Category: Anesthesiology Authors: Z. Khan, J. Hulme, N. Sherwood Source Type: journals

ACR: Drug Delivers Two-Fisted Punch to Fibromyalgia (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PHILADELPHIA (MedPage Today) -- Milnacipran (Savella) improved pain and mental functioning in patients suffering from fibromyalgia, researchers said here.
Source: MedPage Today Pain Management - October 23, 2009 Category: Anesthesiology Source Type: news

ACR: Tanezumab Keeps OA Knee Pain Under Control (CME/CE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PHILADELPHIA (MedPage Today) -- Patients treated with tanezumab, an investigational monoclonal antibody against nerve growth factor, maintained relief from osteoarthritis knee pain over the course of a year, researchers said here.
Source: MedPage Today Pain Management - October 23, 2009 Category: Anesthesiology Source Type: news

Study Assesses Pain Drug Side EffectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new study reports the side effects of oxycodone, a widely used opioid pain medication, are similar in healthy older adults as in younger age groups, therefore, clinicians should not shy away from prescribing the drug to relieve pain in older patients. The article appears in The Journal of Pain, the peer review publication of the American Pain Society.
Source: Pain / Anesthetics News From Medical News Today - October 23, 2009 Category: Anesthesiology Tags: Pain / Anesthetics Source Type: news

AcelRx Announces Positive Results From A Phase 2 Study Of ARX-03, A Sufentanil/Triazolam NanoTab For Procedural Sedation, Anxiolysis & AnalgesiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
AcelRx Pharmaceuticals, Inc. announced positive results from a Phase 2 clinical trial of ARX-03, a proprietary sublingual dosage form combining an opioid, sufentanil, with a benzodiazepine, triazolam. ARX-03 is designed to address the current unmet need for a non-invasive product to provide mild sedation, anxiolysis and analgesia with rapid onset of action for the increasing number of painful and anxiety-producing office-based procedures.
Source: Pain / Anesthetics News From Medical News Today - October 23, 2009 Category: Anesthesiology Tags: Pain / Anesthetics Source Type: news

[Residual curarization and pharyngeal muscles: Remain vigilant!]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The different concepts treating of "residual curarization" were presented according to two directions: the analysis of their contents - epidemiologic, clinical, instrumental - and the description of the pharyngeal striated muscles functions in these contexts. It appears that certain, too marked, "residual curarization" levels remain a well-evidenced factor increasing some morbidities in numerous clinical situations. All the methods of instrumental monitoring of the level of curarization - mecanography, electromyography, accelerometry - appeared useful to document the levels of "residual curarization" before patient's e...
Source: Annales Francaises d'Anesthesie et de Reanimation - October 23, 2009 Category: Anesthesiology Authors: d'Hollander AA, Bourgain JL Tags: Ann Fr Anesth Reanim Source Type: journals

The case for publishing ‘negative’ clinical trialsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Randomized, controlled clinical trials with negative results are viewed with more skepticism than trials with positive results. A widely held assumption is that negative results are not interesting and therefore do not deserve a place in the peer-reviewed literature. Journals may reject manuscripts in the belief that the results represent a false negative because of a flawed study design or poor trial execution. Which is worse? Reporting a false positive result leads to exposing more people to the risk and expense of the treatment. Reporting a false negative result leads to abandonment of a treatment that might be effectiv...
Source: Pain - October 23, 2009 Category: Anesthesiology Authors: Michael C. Rowbotham Tags: Editorial Source Type: journals

Comparison of the intubation with the Storz video laryngoscope and standard direct laryngoscopy in pediatric patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Pediatric Anesthesia - October 22, 2009 Category: Anesthesiology Authors: Fu Shan Xue, Xu Liao, Jian Hua Liu, Yan Ming Zhang Source Type: journals

Reversal of rocuronium-induced profound neuromuscular block by sugammadex in Duchenne muscular dystrophyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A case is reported in which a child with Duchenne muscular dystrophy received a dose of sugammadex to reverse a rocuronium-induced profound neuromuscular block. Sugammadex is the first selective relaxant binding agent and reverses rocuronium- and vecuronium-induced neuromuscular block. A fast and efficient recovery from profound neuromuscular block was achieved, and no adverse events or other safety concerns were observed.
Source: Pediatric Anesthesia - October 22, 2009 Category: Anesthesiology Authors: HANS D. de BOER, JAN van ESMOND, LEO H.J.D. BOOIJ, JACQUES J. DRIESSEN Source Type: journals

Potential hazard of endotracheal tube ISO connectorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Pediatric Anesthesia - October 22, 2009 Category: Anesthesiology Authors: S. Johnston, P. Holmes Source Type: journals

Reduced-dose rocuronium for day-case tonsillectomy in children where volatile anaesthetics are not used: operating room time savingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Reduced-dose rocuronium in addition with propofol and alfentanil in children where volatile anesthetics are not used effectively saves the operating room time during short elective surgical procedures, avoids delays in patient recovery, allows high level of acceptable intubating conditions, and improves the optimal surgical work. Low incidences of PONV as VAS score may achieved successfully.
Source: Pediatric Anesthesia - October 22, 2009 Category: Anesthesiology Authors: DUBRAVKA BARTOLEK, JASMINKA JAKOBOVIĆ, FRANJO BARTOLEK, DIJANA FINCI, ALEKSANDRA MUNJIZA Source Type: journals

An acute pain service improves postoperative pain management for children undergoing selective dorsal rhizotomyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Although we recognize that it is possible that there were changes in care not related specifically to the introduction of a dedicated APS that occurred in our institution that resulted in improvements in general postoperative care and in length of stay, our study did show that having an organized APS allowed to significantly decrease the incidence of postoperative oxygen desaturation and to decrease the hospital length of stay by 1 day.
Source: Pediatric Anesthesia - October 22, 2009 Category: Anesthesiology Authors: CHANTAL FRIGON, WITTHAYA LOETWIRIYAKUL, MANON RANGER, ANNIK OTIS Source Type: journals

School-aged children's experiences of postoperative music medicine on pain, distress, and anxietyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Music medicine reduced the requirement of morphine and decreased the distress after minor surgery but did not else influence the postoperative care.
Source: Pediatric Anesthesia - October 22, 2009 Category: Anesthesiology Authors: STEFAN NILSSON, EVA KOKINSKY, ULRICA NILSSON, BIRGITTA SIDENVALL, KARIN ENSKÄR Source Type: journals

Use of remifentanil as a sedative agent in critically ill adult patients: a meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This meta-analysis examined the benefits of using remifentanil as a sedative agent in critically ill patients. A total of 11 randomised controlled trials, comparing remifentanil with another opioid or hypnotic agent in 1067 critically ill adult patients, were identified from the Cochrane controlled trials register and EMBASE and MEDLINE databases, and subjected to meta-analysis. Remifentanil was associated with a reduction in the time to tracheal extubation after cessation of sedation (weighted-mean-difference [minus]2.04 h (95% CI [minus]0.39 to [minus]3.69 h); p = 0.02). Remifentanil was, however, not associated with a s...
Source: Anaesthesia - October 22, 2009 Category: Anesthesiology Authors: J. A. Tan, K. M. Ho Source Type: journals

Ultrasound guided internal jugular vein access in children and infant: A meta-analysis of published studiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion: This current meta-analysis does not found the utility of ultrasound during IJV access in children and infants in increasing the success rate and in decreasing complications.
Source: Pediatric Anesthesia - October 22, 2009 Category: Anesthesiology Authors: STEPHANIE SIGAUT, ALIA SKHIRI, IDA STANY, JONATHAN GOLMAR, YVES NIVOCHE, ISABELLE CONSTANT, ISABELLE MURAT, SOUHAYL DAHMANI Source Type: journals

Sevoflurane modulation of Ca2+ regulation in skeletal muscle sarcoplasmic reticulum vesicles from young and mature rabbitsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These findings suggest that the sensitivity of the SR to sevoflurane-mediated Ca2+ uptake may be increased with maturity, while an analogous developmental effect on RyR1 is less probable. Nonetheless, this study shows for the first time that a potent inhalational agent such as sevoflurane can influence the high affinity SR calcium-binding site by lowering the extraluminal concentration of calcium necessary to trigger calcium release. While this may not be of consequence when inhaled anesthetics are administered to normal children or adults, it may have life-threatening consequences in carriers of RyR1 mutations.
Source: Pediatric Anesthesia - October 22, 2009 Category: Anesthesiology Authors: MATTHIAS KÖNIG, MARINA LIN, THOMAS E. NELSON, LEANNE GROBAN Source Type: journals

Risk of pulmonary aspiration with laryngeal mask airway and tracheal tube: analysis on 65 712 procedures with positive pressure ventilationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We compared the risk of pulmonary aspiration in patients whose lungs were mechanically ventilated through a laryngeal mask airway (35 630 procedures) or tracheal tube (30 082 procedures). Three cases of pulmonary aspiration occurred with the laryngeal mask airway and seven with the tracheal tube. There were no deaths related to pulmonary aspiration. The incidence and outcome of pulmonary aspiration detected in this study were similar to those previously reported. The adjusted odds ratio (OR) for pulmonary aspiration with the laryngeal mask airway was 1.06 (95% CI 0.20[ndash]5.62). Unplanned surgery (OR 30.5, 95% CI 8.6[nda...
Source: Anaesthesia - October 22, 2009 Category: Anesthesiology Authors: A. Bernardini, G. Natalini Source Type: journals

European CHMP begins referral for modified-release oral opioids following overdose concernsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: EMEA Area: News The European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) has started a referral for modified release oral opioids (morphine, fentanyl, oxycodone and hydromorphone) due to concerns on their dissolution and their sensitivity and interaction with alcohol, which may cause dose dumping and potential overdose.
Source: NeLM - Pain control - October 22, 2009 Category: Anesthesiology Source Type: organizations

European CHMP confirms previous recommendation on withdrawal of non-parenteral dextropropoxyphene-containing medicinesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: EMEA Area: News Finalising a re-examination procedure for dextropropoxyphene-containing medicines, the European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) has confirmed its previous recommendation to withdraw the marketing authorisation for all non-parenteral formulations of these medicines because their risks, particularly the risk of potentially fatal overdose, are greater than their benefits. However, for the parenteral formulation, the Committee concluded that the marketing authorisations should not be withdrawn but suspended until further clinical data are available which may sup...
Source: NeLM - Pain control - October 22, 2009 Category: Anesthesiology Source Type: organizations

Study: No Benefit to Costly Arthritis DrugsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Title: Study: No Benefit to Costly Arthritis DrugsCategory: Health NewsCreated: 10/22/2009 10:28:00 AMLast Editorial Review: 10/22/2009 10:28:58 AM
Source: MedicineNet Chronic Pain General - October 22, 2009 Category: Anesthesiology Source Type: consumer

Unrecognised dural puncture resulting in subdural hygroma and cortical vein thrombosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Unrecognised dural punctures are difficult to diagnose early. Failure of recognition may lead to sinister consequences. A case of unrecognised dural puncture in a young female leading to the development of subdural hygroma and cortical vein thrombosis is presented. The dilemma in the diagnosis of headache in such patients along with the significance of follow-up of all, including attempted, epidurals is also discussed.
Source: Anaesthesia - October 21, 2009 Category: Anesthesiology Authors: A. Sinha, S. Petkov, D. Meldrum Source Type: journals

A comparison of the laryngeal mask airway with the facemask and oropharyngeal airway for manual ventilation by first responders in childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In adults, first responders to a cardiopulmonary arrest provide better ventilation using a laryngeal mask airway than a facemask. It is unclear if the same is true in children. We investigated this by comparing the ability of 36 paediatric ward nurses to ventilate the lungs of 99 anaesthetised children (a model for cardiopulmonary arrest) using a laryngeal mask airway and using a facemask with an oropharyngeal airway. Anteroposterior chest wall displacement was measured using an ultrasonic detector. Nurses achieved successful ventilation in 74 (75%) of cases with the laryngeal mask airway and 76 (77%) with facemask and oro...
Source: Anaesthesia - October 21, 2009 Category: Anesthesiology Authors: A. E. Blevin, S. F. McDouall, J. A. Rechner, T. A. Saunders, V. S. Barber, J. D. Young, D. G. Mason Source Type: journals

Anosmia after general anaesthesia: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present the case of a 60-year-old female patient with a 3-month history of altered smell and taste immediately after recovery from general anaesthesia for a urological operation. The anaesthetic drugs used were fentanyl, propofol and sevoflurane. Clinical examination and a computed tomography brain scan did not reveal any pathology. Psychophysical testing showed anosmia and normal taste function. Imaging studies using single photon emission computed tomography of the brain were performed twice: as a baseline examination; and after odour stimulation with phenyl ethyl alcohol. Normal brain activity without reaction to odo...
Source: Anaesthesia - October 21, 2009 Category: Anesthesiology Authors: I. Konstantinidis, E. Tsakiropoulou, I. Iakovou, A. Douvantzi, S. Metaxas Source Type: journals

Tracheal intubation in patients with rigid collar immobilisation of the cervical spine: a comparison of Airtraq® and LMA CTrach™ devices*Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to evaluate the effectiveness of the Airtraq® and CTrach[trade] in lean patients with simulated cervical spine injury after application of a rigid cervical collar. Eighty-six consenting adult patients of ASA physical status 1 or 2, who required elective tracheal intubation were included in this study in a randomised manner. Anaesthesia was induced using 1 [mu]g.kg[minus]1 fentanyl, 3 mg.kg[minus]1 propofol and 0.6 mg.kg[minus]1 rocuronium, following which a rigid cervical collar was applied. Comparison was then made between tracheal intubation techniques using either the AirTraq or CTrach device....
Source: Anaesthesia - October 21, 2009 Category: Anesthesiology Authors: Z. I. Arslan, T. Yildiz, Z. N. Baykara, M. Solak, K. Toker Source Type: journals

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