Biochemistry
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Proteomic Analysis of Plasma from Patients Undergoing Coronary Artery Bypass Grafting Reveals a Protease/Antiprotease Imbalance in Favor of the Serpin α1-Antichymotrypsin
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Journal of Proteome Research, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Proteome Research)
Source: Journal of Proteome Research - March 20, 2010 Category: Biochemistry Tags: article Source Type: journals
An Unprecedented Biogenetic-Type Chemical Synthesis of 1(15→11) Abeotaxanes from Normal TaxanesEmail this article to a colleague.
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Journal of Natural Products, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Natural Products)
Source: Journal of Natural Products - March 20, 2010 Category: Biochemistry Tags: article Source Type: journals
X-ray Crystallographic Analyses of Pig Pancreatic α-Amylase with Limit Dextrin, Oligosaccharide, and α-CyclodextrinEmail this article to a colleague.
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Biochemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Biochemistry)
Source: Biochemistry - March 20, 2010 Category: Biochemistry Tags: article Source Type: journals
Stabilized 111In-Labeled sCCK8 Analogues for Targeting CCK2-Receptor Positive Tumors: Synthesis and EvaluationEmail this article to a colleague.
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Bioconjugate Chemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Bioconjugate Chemistry)
Source: Bioconjugate Chemistry - March 20, 2010 Category: Biochemistry Tags: article Source Type: journals
The Same Kind Of Circadian Rhythms That Govern Human Sleep Control Cell Division In CyanobacteriaEmail this article to a colleague.
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A team of researchers at MIT and the University of California at San Diego has shown how cell division in a type of bacteria known as cyanobacteria is controlled by the same kind of circadian rhythms that govern human sleep patterns... (Source: Biology / Biochemistry News From Medical News Today)
Source: Biology / Biochemistry News From Medical News Today - March 20, 2010 Category: Biochemistry Tags: Biology / Biochemistry Source Type: news
'Glow-In-The-Dark' Sperm Sheds Light On Sexual SelectionEmail this article to a colleague.
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Previously unobservable events occurring between insemination and fertilization are the subject of a groundbreaking new article in Science magazine (March 18) by Mollie Manier, John Belote and Scott Pitnick, professors of biology in Syracuse University's College of Arts and Sciences... (Source: Biology / Biochemistry News From Medical News Today)
Source: Biology / Biochemistry News From Medical News Today - March 20, 2010 Category: Biochemistry Tags: Biology / Biochemistry Source Type: news
Context Dependence of Trinucleotide Repeat StructuresEmail this article to a colleague.
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Biochemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Biochemistry)
Source: Biochemistry - March 19, 2010 Category: Biochemistry Tags: article Source Type: journals
Crystallographic and Single-Crystal Spectral Analysis of the Peroxidase Ferryl IntermediateEmail this article to a colleague.
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Biochemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Biochemistry)
Source: Biochemistry - March 19, 2010 Category: Biochemistry Tags: article Source Type: journals
Biochemical Characterization of ThiT from Lactococcus lactis: A Thiamin Transporter with Picomolar Substrate Binding AffinityEmail this article to a colleague.
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Biochemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Biochemistry)
Source: Biochemistry - March 19, 2010 Category: Biochemistry Tags: article Source Type: journals
Possible Important Pair of Acidic Residues in Vesicular Acetylcholine TransporterEmail this article to a colleague.
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Biochemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Biochemistry)
Source: Biochemistry - March 19, 2010 Category: Biochemistry Tags: article Source Type: journals
Partial Steps of Charge Translocation in the Nonpumping N139L Mutant of Rhodobacter sphaeroides Cytochrome c Oxidase with a Blocked D-ChannelEmail this article to a colleague.
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Biochemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Biochemistry)
Source: Biochemistry - March 19, 2010 Category: Biochemistry Tags: article Source Type: journals
An Exposed Cysteine Residue of Human Angiostatic Mini Tryptophanyl-tRNA SynthetaseEmail this article to a colleague.
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Biochemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Biochemistry)
Source: Biochemistry - March 19, 2010 Category: Biochemistry Tags: article Source Type: journals
Protein Expression Profiles of Necrosis and Apoptosis Induced by 5-Fluoro-2′-deoxyuridine in Mouse Cancer CellsEmail this article to a colleague.
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Journal of Proteome Research, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Proteome Research)
Source: Journal of Proteome Research - March 19, 2010 Category: Biochemistry Tags: article Source Type: journals
Analysis of the Ontogenetic Variation in the Venom Proteome/Peptidome of Bothrops jararaca Reveals Different Strategies to Deal with PreyEmail this article to a colleague.
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Journal of Proteome Research, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Proteome Research)
Source: Journal of Proteome Research - March 19, 2010 Category: Biochemistry Tags: article Source Type: journals
Enzymatic Kinetic Resolution of Silybin Diastereoisomers⊥Email this article to a colleague.
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Journal of Natural Products, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Natural Products)
Source: Journal of Natural Products - March 19, 2010 Category: Biochemistry Tags: article Source Type: journals
Multifunctional Polymer Neutralizes Both Biological And Chemical WeaponsEmail this article to a colleague.
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In an ongoing effort to mirror the ability of biological tissues to respond rapidly and appropriately to changing environments, scientists from the McGowan Institute for Regenerative Medicine have synthesized a single, multifunctional polymer material that can decontaminate both biological and chemical toxins. They described the findings recently in Biomaterials... (Source: Biology / Biochemistry News From Medical News Today)
Source: Biology / Biochemistry News From Medical News Today - March 19, 2010 Category: Biochemistry Tags: Biology / Biochemistry Source Type: news
'Flying Vaccinator': Can Genetically Engineered Mosquitoes Provide A New Strategy Against Malaria?Email this article to a colleague.
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Mosquitoes transmit infectious diseases to millions of people every year, including malaria for which there is no effective vaccine. New research published in Insect Molecular Biology reveals that mosquito genetic engineering may turn the transmitter into a natural 'flying vaccinator', providing a new strategy for biological control over the disease... (Source: Biology / Biochemistry News From Medical News Today)
Source: Biology / Biochemistry News From Medical News Today - March 19, 2010 Category: Biochemistry Tags: Tropical Diseases Source Type: news
Wnt signalling and the control of cellular metabolism.Email this article to a colleague.
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At the cellular level, the biological processes of cell proliferation, growth arrest, differentiation and apoptosis are all tightly coupled to appropriate alterations in metabolic status. In the case of cell proliferation, this requires redirecting metabolic pathways to provide the fuel and basic components for new cells. Ultimately, the successful co-ordination of cell-specific biology with cellular metabolism underscores multicellular processes as diverse as embryonic development, adult tissue remodelling and cancer cell biology. The Wnt signalling network has been implicated in all of these areas. While each of the ...
Source: The Biochemical Journal - March 19, 2010 Category: Biochemistry Authors: Sethi JK, Vidal-Puig A Tags: Biochem J Source Type: journals
Iron binding activity of human iron-sulfur cluster assembly protein hIscA-1Email this article to a colleague.
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A human homologue of the iron-sulfur cluster assembly protein IscA (hIscA1) has been cloned and expressed in Escherichia coli cells. The UV-visible absorption and EPR (electron paramagnetic resonance) measurements reveal that hIscA1 purified from E. coli cells contains a mononuclear iron center and that the iron binding in hIscA1 expressed in E. coli cells can be further modulated by the iron content in the cell growth medium. Additional studies show that purified hIscA1 binds iron with an iron association constant of approx. 2.0 x 1019 M-1, and that the iron-bound hIscA1 is able to provide the iron for the iron-sulfur clu...
Source: BJ Energy - March 19, 2010 Category: Biochemistry Authors: J Lu, J P. Bitoun, G Tan, W Wang, W Min, H Ding Tags: BJ Energy Source Type: journals
On the conformations and properties of the L-tryptophyl-containing peptides in solution, depending of the pH - theoretical study vs. experimentsEmail this article to a colleague.
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The conformational preference and electronic properties of three L-tryptophyl-containing dipeptides, i.e. glycyl-L-tryptophane (H-Gly-Trp-OH), L-alanyl-L-tryptophane (H-Ala-Trp-OH) and L-methionyl-L-tryptophane (L-Met-Trp-OH) in solution depending on the pH of the media are studied both theoretically and experimentally. The effect of the protonation of the COO- and deprotonation of the NH3+ as well as the alkaline hydrolysis of the amide fragment in a strong basic media on the electronic spectra are discussed. Ab initio and DFT methods as well as the time-dependent DFT (TD-DFT) method as a function of the basis set are per...
Source: Biopolymers - March 19, 2010 Category: Biochemistry Authors: Bojidarka B. Ivanova, Michael Spiteller Source Type: journals
Diarylheptanoid from Pleuranthodium racemigerum with in Vitro Prostaglandin E2 Inhibitory and Cytotoxic ActivityEmail this article to a colleague.
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Journal of Natural Products, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Natural Products)
Source: Journal of Natural Products - March 18, 2010 Category: Biochemistry Tags: article Source Type: journals
The Discovery of Novel Experimental Therapies for Inflammatory ArthritisEmail this article to a colleague.
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Conventional and biologic disease-modifying antirheumatic drugs have revolutionized the medical therapy of inflammatory arthritis. However, it remains unclear as to what can be done to treat immune-mediated chronic inflammation after patients become refractory to these therapies or develop serious side-effects and/or infections forcing drug withdrawal. Because of these concerns it is imperative that novel targets be continuously identified and experimental strategies designed to test potential arthritis interventions in vitro, but more importantly, in well-validated animal models of inflammatory arthritis. Over the past fe...
Source: Mediators of Inflammation - March 18, 2010 Category: Biochemistry Source Type: journals
Proteomic Analysis Reveals Virus-Specific Hsp25 Modulation in Cardiac MyocytesEmail this article to a colleague.
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Journal of Proteome Research, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Proteome Research)
Source: Journal of Proteome Research - March 18, 2010 Category: Biochemistry Tags: article Source Type: journals
Structural Characterization of Glycans on Omega-1, a Major Schistosoma mansoni Egg Glycoprotein That Drives Th2 ResponsesEmail this article to a colleague.
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Journal of Proteome Research, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Proteome Research)
Source: Journal of Proteome Research - March 18, 2010 Category: Biochemistry Tags: article Source Type: journals
Increasing Understanding Of Drug Metabolism Provides Key Knowledge About Drug Toxicity And EffectivenessEmail this article to a colleague.
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Research led by Wayne L... (Source: Biology / Biochemistry News From Medical News Today)
Source: Biology / Biochemistry News From Medical News Today - March 18, 2010 Category: Biochemistry Tags: Biology / Biochemistry Source Type: news
Identification Of Key Mechanism That Guides Cells To Form Heart TissueEmail this article to a colleague.
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Researchers at the Keck School of Medicine of the University of Southern California (USC) have identified a key cellular mechanism that guides embryonic heart tissue formation - a process which, if disrupted, can lead to a number of common congenital heart defects... (Source: Biology / Biochemistry News From Medical News Today)
Source: Biology / Biochemistry News From Medical News Today - March 18, 2010 Category: Biochemistry Tags: Cardiovascular / Cardiology Source Type: news
The Molecular Basis Of Detecting Tissue-Damaging Chemicals Goes Back More 500 Million YearsEmail this article to a colleague.
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Whenever you choke on acrid cigarette smoke, feel like you're burning up from a mouthful of wasabi-laced sushi, or cry while cutting raw onions and garlic, your response is being triggered by a primordial chemical sensor conserved across some 500 million years of animal evolution, report Brandeis University scientists in a study in Nature this week... (Source: Biology / Biochemistry News From Medical News Today)
Source: Biology / Biochemistry News From Medical News Today - March 18, 2010 Category: Biochemistry Tags: Biology / Biochemistry Source Type: news
Multimethodological Approach to Identification of Glycoproteins from the Proteome of Francisella tularensis, an Intracellular MicroorganismEmail this article to a colleague.
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Journal of Proteome Research, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Proteome Research)
Source: Journal of Proteome Research - March 18, 2010 Category: Biochemistry Tags: article Source Type: journals
Book Review of The Science of ChocolateEmail this article to a colleague.
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Journal of Natural Products, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Natural Products)
Source: Journal of Natural Products - March 18, 2010 Category: Biochemistry Tags: book review Source Type: journals
Coordinated Chromatin Control: Structural and Functional Linkage of DNA and Histone MethylationEmail this article to a colleague.
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Biochemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Biochemistry)
Source: Biochemistry - March 18, 2010 Category: Biochemistry Tags: article Source Type: journals
New Nanosized Biocompatible MR Contrast Agents Based on Lysine-Dendri-Graft MacromoleculesEmail this article to a colleague.
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Bioconjugate Chemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Bioconjugate Chemistry)
Source: Bioconjugate Chemistry - March 18, 2010 Category: Biochemistry Tags: article Source Type: journals
[beta]-sheet aggregation of kisspeptin-10 is stimulated by heparin but inhibited by amphiphilesEmail this article to a colleague.
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The murine 10-residue neurohormone kisspeptin (YNWNSFGLRY) is an important regulator of reproductive behavior and gonadotrophin secretion. It is known to form a random coil in solution, but undergoes a structural change in the presence of membranes although the nature of this change is not fully determined. The peptide's conformational versatility raises the question whether it is also able to form ordered aggregates under physiological conditions, which might be relevant as a storage mechanism. Here we show that heparin induces kisspeptin to form [beta]-sheet rich amyloid aggregates both at neutral (pH 7.0) and slightly a...
Source: Biopolymers - March 18, 2010 Category: Biochemistry Authors: Søren B. Nielsen, Magnus Franzmann, Rajiv V. Basaiawmoit, Reinhard Wimmer, Jens D. Mikkelsen, Daniel E. Otzen Source Type: journals
Particle trapping using dielectrophoretically patterned carbon nanotubesEmail this article to a colleague.
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This study presents the dielectrophoretic (DEP) assembly of multi-walled carbon nanotubes (MWCNTs) between curved microelectrodes for the purpose of trapping polystyrene microparticles within a microfluidic system. Under normal conditions, polystyrene particles exhibit negative DEP behaviour and are repelled from microelectrodes. Interestingly, the addition of MWCNTs to the system alters this situation in two ways: first, they coat the surface of particles and change their dielectric properties to exhibit positive DEP behaviour; second, the assembled MWCNTs are highly conductive and after the deposition serve as extensions...
Source: Electrophoresis - March 18, 2010 Category: Biochemistry Authors: Khashayar Khoshmanesh, Chen Zhang, Saeid Nahavandi, Francisco J. Tovar-Lopez, Sara Baratchi, Zheng Hu, Arnan Mitchell, Kourosh Kalantar-zadeh Source Type: journals
Continuous dielectrophoretic separation of particles in a spiral microchannelEmail this article to a colleague.
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This article introduces a novel particle separation technique in DC electrokinetic flow through a planar double-spiral microchannel. The continuous separation arises from the cross-stream dielectrophoretic motion of particles induced by the non-uniform electric field inherent to curved channels. Specifically, particles are focused by DEP to one sidewall of the first spiral, and then dielectrophoretically deflected toward the other sidewall of the second spiral at a particle-dependent rate, leading to focused particle streams along different flow paths. This DEP-based particle separation technique is demonstrated in an asym...
Source: Electrophoresis - March 18, 2010 Category: Biochemistry Authors: Junjie Zhu, Tzuen-Rong J. Tzeng, Xiangchun Xuan Source Type: journals
Improved sample preparation method for glycan analysis of glycoproteins by CE-LIF and CE-MSEmail this article to a colleague.
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CE is a high-resolution separation technique broadly used in the biotechnology industry for carbohydrate analysis. The standard sample preparation protocol for CE analysis of glycans released from glycoproteins generally requires derivatization times of overnight at 37°C, using [ge]100 fold excess of fluorophore reagent, 8-aminopyrene-1,3,6-trisulfonic-acid, if the sample is unknown, or it is a regulated biotherapeutic product, possibly containing terminal sialic acid(s). In this paper, we report on significant improvements for the standard CE sample preparation method of glycan analysis. By replacing the conventionally u...
Source: Electrophoresis - March 18, 2010 Category: Biochemistry Authors: Zoltan Szabo, András Guttman, Tomas Rejtar, Barry L. Karger Source Type: journals
Pumpless dispensing of a droplet by breaking up a liquid bridge formed by electric inductionEmail this article to a colleague.
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In this study, a new method is suggested and demonstrated for dispensing a droplet on the top plate with an inverted geometry by using electric field. The process of dispensing droplets consists of two stages: (i) formation of liquid bridge by moving up the charged fluid mass using the electrostatic force between the charges on the fluid mass and the induced charges on the substrate and (ii) its break-up by the motion of the top plate. Different from conventional electrohydrodynamic methods, electric induction enables the droplets to be dispensed on various surfaces including non-conducting substrate. The use of capillarit...
Source: Electrophoresis - March 18, 2010 Category: Biochemistry Authors: Jin Seok Hong, Beom Seok Lee, Dustin Moon, Jeong-Gun Lee, In Seok Kang Source Type: journals
C-terminal domain phosphorylation of ERK3 controlled by Cdk1 and Cdc14 regulates its stability in mitosisEmail this article to a colleague.
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Extracellular signal-regulated kinase 3 (ERK3) is an atypical mitogen-activated protein kinase that is suggested to play a role in cell cycle progression and cellular differentiation. However, it is not known if the function of ERK3 is regulated during the cell cycle. Here, we report that ERK3 is stoichiometrically hyperphosphorylated during entry into mitosis and is dephosphorylated at the M→G1 transition. The phosphorylation of ERK3 is associated with the accumulation of the protein in mitosis. In vitro phosphorylation of a series of ERK3 deletion mutants by mitotic cell extracts revealed that phosphorylation is c...
Source: BJ Cell - March 18, 2010 Category: Biochemistry Authors: P Tanguay, G Rodier, S Meloche Tags: BJ Cell Source Type: journals
Purification and refolding of E.coli-expressed recombinant human interleukin-2Email this article to a colleague.
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The expression of recombinant human interleukin-2 (rhIL-2) in bacteria results in the formation of insoluble inclusion-body aggregates. These aggregates were first solubilized under denaturing conditions (solution of buffer phosphate containing 8 M urea and 10 mM mercaptoethanol) and then purified using immobilized metal affinity chromatography (IMAC). IMAC was used to capture rhIL-2. The protein was gradually refolded on the column by a gradient elution (8 M to 0 M urea) in the presence of 10% glycerol. Glycerol was used to abolish the protein aggregation during the refolding step. By this method, rhIL-2 was collected at ...
Source: Biotechnology and Applied Biochemistry - March 18, 2010 Category: Biochemistry Authors: S Esfandiar, S Hashemi-Najafabadi, S Shojaosadati, S Sarrafzadeh, Z Pourpak Source Type: journals
Optimizing Performance of Glycopeptide Capture for Plasma ProteomicsEmail this article to a colleague.
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Journal of Proteome Research, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Proteome Research)
Source: Journal of Proteome Research - March 17, 2010 Category: Biochemistry Tags: article Source Type: journals
Editorial BoardEmail this article to a colleague.
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(Source: FEBS Letters)
Source: FEBS Letters - March 17, 2010 Category: Biochemistry Source Type: journals
Book Review of The Chemistry of Fragrances. From Perfumer to ConsumerEmail this article to a colleague.
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Journal of Natural Products, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Natural Products)
Source: Journal of Natural Products - March 17, 2010 Category: Biochemistry Tags: book review Source Type: journals
Book Review of Molecules and MedicineEmail this article to a colleague.
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Journal of Natural Products, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Natural Products)
Source: Journal of Natural Products - March 17, 2010 Category: Biochemistry Tags: book review Source Type: journals
Antitrypanosomal Cyclic Polyketide Peroxides from the Australian Marine Sponge Plakortis spEmail this article to a colleague.
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Journal of Natural Products, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Natural Products)
Source: Journal of Natural Products - March 17, 2010 Category: Biochemistry Tags: article Source Type: journals
Practically Useful: What the Rosetta Protein Modeling Suite Can Do for YouEmail this article to a colleague.
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Biochemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Biochemistry)
Source: Biochemistry - March 17, 2010 Category: Biochemistry Tags: article Source Type: journals
Hydrogen Tunneling in Adenosylcobalamin-Dependent Glutamate Mutase: Evidence from Intrinsic Kinetic Isotope Effects Measured by Intramolecular CompetitionEmail this article to a colleague.
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Biochemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Biochemistry)
Source: Biochemistry - March 17, 2010 Category: Biochemistry Tags: article Source Type: journals
Peroxynitrite Induces Destruction of the Tetrahydrobiopterin and Heme in Endothelial Nitric Oxide Synthase: Transition from Reversible to Irreversible Enzyme InhibitionEmail this article to a colleague.
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Biochemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Biochemistry)
Source: Biochemistry - March 17, 2010 Category: Biochemistry Tags: article Source Type: journals
Book Review of Molecules that Changed the WorldEmail this article to a colleague.
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Journal of Natural Products, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Natural Products)
Source: Journal of Natural Products - March 17, 2010 Category: Biochemistry Tags: book review Source Type: journals
How Cells Protect Themselves From CancerEmail this article to a colleague.
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Cells have two different protection programs to safeguard them from getting out of control under stress and from dividing without stopping and developing cancer. Until now, researchers assumed that these protective systems were prompted separately from each other... (Source: Biology / Biochemistry News From Medical News Today)
Source: Biology / Biochemistry News From Medical News Today - March 17, 2010 Category: Biochemistry Tags: Lymphoma / Leukemia / Myeloma Source Type: news
Long Polymer Chains Dance The CongaEmail this article to a colleague.
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Understanding the steps to the intricate dance inside a cell is essential to one day choreographing the show. By studying the molecules that give a cell its structure, University of Illinois researchers are moving closer to understanding one of those steps: the conga line... (Source: Biology / Biochemistry News From Medical News Today)
Source: Biology / Biochemistry News From Medical News Today - March 17, 2010 Category: Biochemistry Tags: Biology / Biochemistry Source Type: news
A Flexible Bipartite Coiled Coil Structure Is Required for the Interaction of Hexim1 with the P-TEFb Subunit Cyclin T1Email this article to a colleague.
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Biochemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Biochemistry)
Source: Biochemistry - March 17, 2010 Category: Biochemistry Tags: article Source Type: journals
