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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 25.

An Inductively Powered Implantable Blood Flow Sensor Microsystem for Vascular Grafts
Monitoring blood flow rate inside prosthetic vascular grafts enables an early detection of the graft degradation, followed by the timely intervention and prevention of the graft failure. This paper presents an inductively powered implantable blood flow sensor microsystem with bidirectional telemetry. The microsystem integrates silicon nanowire (SiNW) sensors with tunable piezoresistivity, an ultralow-power application-specific integrated circuit (ASIC), and two miniature coils that are coupled with a larger coil in an external monitoring unit to form a passive wireless link. Operating at 13.56-MHz carrier frequency, the im...
Source: IEEE Transactions on Biomedical Engineering - September 1, 2012 Category: Biomedical Engineering Source Type: research

Design of an Optical System for Interrogation of Implanted Luminescent Sensors and Verification with Silicone Skin Phantoms
Implantable luminescent sensors are being developed for on-demand monitoring of blood glucose levels. For these sensors to be deployed in vivo, a matched external hardware system is needed. In this paper, we designed a compact, low-cost optical system with highly efficient photon delivery and collection using advanced optical modeling software. Compared to interrogation with a fiber bundle, the new system was predicted to improve interrogation efficiency by a factor of 200 for native sensors; an improvement of 37 times was predicted for sensors implanted at a depth of 1 mm in a skin-simulating phantom. A phys...
Source: IEEE Transactions on Biomedical Engineering - September 1, 2012 Category: Biomedical Engineering Source Type: research

An Integrated Segmentation and Analysis Approach for QCT of the Knee to Determine Subchondral Bone Mineral Density and Texture
We have developed a new integrated approach for quantitative computed tomography of the knee in order to quantify bone mineral density (BMD) and subchondral bone structure. The present framework consists of image acquisition and reconstruction, 3-D segmentation, determination of anatomic coordinate systems, and reproducible positioning of analysis volumes of interest (VOI). Novel segmentation algorithms were developed to identify growth plates of the tibia and femur and the joint space with high reproducibility. Five different VOIs with varying distance to the articular surface are defined in the epiphysis. Each VOI is fur...
Source: IEEE Transactions on Biomedical Engineering - September 1, 2012 Category: Biomedical Engineering Source Type: research

Dual-Window Dual-Bandwidth Spectroscopic Optical Coherence Tomography Metric for Qualitative Scatterer Size Differentiation in Tissues
This study investigates the autocorrelation bandwidths of dual-window (DW) optical coherence tomography (OCT) k-space scattering profile of different-sized microspheres and their correlation to scatterer size. A dual-bandwidth spectroscopic metric defined as the ratio of the 10% to 90% autocorrelation bandwidths is found to change monotonically with microsphere size and gives the best contrast enhancement for scatterer size differentiation in the resulting spectroscopic image. A simulation model supports the experimental results and revealed a tradeoff between the smallest detectable scatterer size and the ma...
Source: IEEE Transactions on Biomedical Engineering - September 1, 2012 Category: Biomedical Engineering Source Type: research

A Preclinical System Prototype for Focused Microwave Thermal Therapy of the Breast
A preclinical prototype of a transcutaneous thermal therapy system has been developed for the targeted treatment of breast cancer cells using focused microwaves as an adjuvant to radiation, chemotherapy, and high-intensity-focused ultrasound. The prototype system employs a 2-D array of tapered microstrip patch antennas operating at 915 MHz to focus continuous-wave microwave energy transcutaneously into the pendent breast suspended in a coupling medium. Prior imaging studies are used to ascertain the material properties of the breast tissue, and these data are incorporated into a multiphysics model. Time-reversal tec...
Source: IEEE Transactions on Biomedical Engineering - September 1, 2012 Category: Biomedical Engineering Source Type: research

Realtime Recognition of Complex Human Daily Activities Using Human Motion and Location Data
Daily activity recognition is very useful in robot-assisted living systems. In this paper, we proposed a method to recognize complex human daily activities which consist of simultaneous body activities and hand gestures in an indoor environment. A wireless power-aware motion sensor node is developed which consists of a commercial orientation sensor, a wireless communication module, and a power management unit. To recognize complex daily activities, three motion sensor nodes are attached to the right thigh, the waist, and the right hand of a human subject, while an optical motion capture system is used to obtain his/her loc...
Source: IEEE Transactions on Biomedical Engineering - September 1, 2012 Category: Biomedical Engineering Source Type: research

A Finite Difference Method for the Design of Gradient Coils in MRI—An Initial Framework
This paper proposes a finite-difference (FD)-based method for the design of gradient coils in MRI. The design method first uses the FD approximation to describe the continuous current density of the coil space and then employs the stream function method to extract the coil patterns. During the numerical implementation, a linear equation is constructed and solved using a regularization scheme. The algorithm details have been exemplified through biplanar and cylindrical gradient coil design examples. The design method can be applied to unusual coil designs such as ultrashort or dedicated gradient coils. The proposed gradient...
Source: IEEE Transactions on Biomedical Engineering - September 1, 2012 Category: Biomedical Engineering Source Type: research

Personalized Tooth Shape Estimation From Radiograph and Cast
Three-dimensional geometric information of teeth is usually needed in pre- and postoperative diagnoses of orthodontic dentistry. The computerized tomography can provide comprehensive 3-D teeth geometries. However, there is still a discussion on computed tomography (CT) as a routine in orthodontic dentistry due to radiation dose. Moreover, the CT is useless when a dentist needs to extract 3-D structures from old archive files with only radiographs and casts, where patient’s teeth changed ever since. In this paper, we propose a reconstruction framework for patient-specific teeth based on an integration of 2-D radiogra...
Source: IEEE Transactions on Biomedical Engineering - September 1, 2012 Category: Biomedical Engineering Source Type: research

A Review of Localization Systems for Robotic Endoscopic Capsules
Obscure gastrointestinal (GI) bleeding, Crohn disease, Celiac disease, small bower tumors, and other disorders that occur in the GI tract have always been challenging to be diagnosed and treated due to the inevitable difficulty in accessing such a complex environment within the human body. With the invention of wireless capsule endoscope, the next generation of the traditional cabled endoscope, not only a dream has come true for the patients who have experienced a great discomfort and unpleasantness caused by the conventional endoscopic method, but also a new research field has been opened to develop a complete miniature r...
Source: IEEE Transactions on Biomedical Engineering - September 1, 2012 Category: Biomedical Engineering Source Type: research

Nonlocal Means Denoising of ECG Signals
Patch-based methods have attracted significant attention in recent years within the field of image processing for a variety of problems including denoising, inpainting, and super-resolution interpolation. Despite their prevalence for processing 2-D signals, they have received little attention in the 1-D signal processing literature. In this letter, we explore application of one such method, the nonlocal means (NLM) approach, to the denoising of biomedical signals. Using ECG as an example, we demonstrate that a straightforward NLM-based denoising scheme provides signal-to-noise ratio improvements very similar to state of th...
Source: IEEE Transactions on Biomedical Engineering - September 1, 2012 Category: Biomedical Engineering Source Type: research

Table of contents
Source: IEEE Transactions on Biomedical Engineering - September 1, 2012 Category: Biomedical Engineering Source Type: research

IEEE Transactions on Biomedical Engineering publication information
"Provides a listing of current staff, committee members and society officers."
Source: IEEE Transactions on Biomedical Engineering - September 1, 2012 Category: Biomedical Engineering Source Type: research

[Front cover]
Presents the cover/table of contents for this issue of the periodical.
Source: IEEE Transactions on Biomedical Engineering - September 1, 2012 Category: Biomedical Engineering Source Type: research

Enhanced phase synchronization of blood flow oscillations between heated and adjacent non-heated sacral skin
Abstract The study of skin microcirculation may be used to assess risk for pressure ulcers. It is observed that local heating causes an increase in blood flow of not only the heated skin, but also in the adjacent non-heated skin. The underlying physiological mechanism of this indirect vasodilation of the non-heated skin remains unclear. We hypothesized that blood flow oscillations (BFO) in the adjacent non-heated skin area synchronize with BFO in the heated skin, thus inducing a vasodilatory response. We investigated BFO in the heated and adjacent non-heated skin (12.1 ± 1.2-cm distance) on the sa...
Source: Medical and Biological Engineering and Computing - August 31, 2012 Category: Biomedical Engineering Tags: Medical and Biological Engineering and Computing Source Type: research

Moderate alcohol consumption is associated with improved insulin sensitivity, reduced basal insulin secretion rate and lower fasting glucagon concentration in healthy women
Conclusions/interpretation Light-to-moderate alcohol consumption was associated in healthy women with enhanced insulin sensitivity, reduced basal insulin secretion rate and lower fasting plasma glucagon concentration, providing consistent mechanisms for the reduced risk of diabetes. Content Type Journal ArticleCategory ArticlePages 1-10DOI 10.1007/s00125-012-2701-3Authors F. Bonnet, Service Endocrinologie–Diabétologie, CHU Rennes, Université Rennes 1, Inserm UMR 991, Rennes, FranceE. Disse, Centre de Recherche en Nutrition Humaine, CRNH Rhône-Alpes, Inserm U1060-INRA 1235, Lyon, FranceM. Laville...
Source: Diabetologia - August 30, 2012 Category: Endocrinology Tags: Diabetologia Source Type: research

CAPE suppresses VEGFR-2 activation, and tumor neovascularization and growth
Abstract The growth and metastasis of human solid tumors and the development of conditions such as diabetic retinopathy, rheumatoid arthritis, inflammatory psoriasis, and others are regulated by the balance between angiogenic stimulators and inhibitors released in the angiogenic–pathological microenvironment. Vascular endothelial growth factor (VEGF), an angiogenic factor, is a potent endothelial-specific mitogen that activates endothelial cells in pathological angiogenesis. Recently, we demonstrated that caffeic acid phenethyl ester (CAPE) inhibits tumor growth, invasion, and metastasis. However, the prec...
Source: Journal of Molecular Medicine - August 30, 2012 Category: Molecular Biology Tags: Journal of Molecular Medicine Source Type: research

Highly thermo-halo-alkali-stable β-1,4-endoxylanase from a novel polyextremophilic strain of Bacillus halodurans.
Abstract A novel bacterial isolate, capable of producing extracellular highly thermostable, halo-alkali-stable and cellulase-free xylanase, was isolated from soil and identified as Bacillus halodurans TSPV1 by polyphasic approach. The Plackett-Burman design identified wheat bran, lactose, tryptone and NaCl as the factors that significantly affect xylanase production, and thus, these were optimized by response surface methodology. The data analysis suggested that optimum levels of wheat bran (15-20 g L(-1)), lactose (1.0-1.5 g L(-1)), tryptone (2-2.5 g L(-1)) and NaCl (7.0-8.0 g L(-1)) support 6.75-fold high...
Source: Bioprocess and Biosystems Engineering - August 30, 2012 Category: Biomedical Engineering Authors: Kumar V, Syal P, Satyanarayana T Tags: Bioprocess Biosyst Eng Source Type: research

Thermally biased AC electrokinetic pumping effect for Lab-on-a-chip based delivery of biofluids.
Abstract One major motivation for microfluidic research is to develop point of care diagnostic tools, which often demands a solution for chip-scale pumping that is of low cost, small size and light weight. Electrokinetics has been extensively studied for disposable pumping since only electrodes are needed to induce microflows. However, it encounters difficulties with conductive biofluids because of the associated high salt content. In electrokinetic pumps, electrodes are in direct contact with fluid, so high salt content will compress the electric double layer that is essential to electroosmostic flows. Alternating...
Source: Biomedical Microdevices - August 30, 2012 Category: Biomedical Engineering Authors: Yuan Q, Wu J Tags: Biomed Microdevices Source Type: research

Impedimetric monitoring of IGF-1 protection of in vitro cortical neurons under ischemic conditions.
Abstract Microelectrode arrays (MEAs) incorporated with the electric cell substrate impedance sensing (ECIS) technique provide a method for acquiring cellular electrophysiological information, which is useful for the time-course monitoring of cellular outgrowth and damage. This research utilizes the ECIS technique for monitoring the time-course impedimetric changes in normal and insulin-like growth factor 1 (IGF-1)-protected cortical neurons under the ischemic insult of oxygen glucose deprivation (OGD) created in a microperfusion environment. The neuronal apoptosis is reflected by the relatively low cell viability ...
Source: Biomedical Microdevices - August 30, 2012 Category: Biomedical Engineering Authors: Huang SH, Lin SP, Liang CK, Chen JJ Tags: Biomed Microdevices Source Type: research

Editorial Board
Source: Medical Engineering and Physics - August 29, 2012 Category: Biomedical Engineering Source Type: research

Telemetry capsule for measuring contractile motion in the small intestine.
Abstract The aim of this study was to develop a capsule which can measure contractions in the small intestine. Currently available methods cause discomfort to the patient while taking measurements; with the development of a telemetry capsule that can measure contractions, patients can avoid pain and continue with ordinary activities while the information is automatically collected from the external receiver. In order to develop the contraction force measuring capsule, various types of silicone transducers were designed and implemented to measure the contraction pressure in the small intestine. The minimum resolutio...
Source: Biomedical Microdevices - August 29, 2012 Category: Biomedical Engineering Authors: Woo SH, Mohy-Ud-Din Z, Cho JH Tags: Biomed Microdevices Source Type: research

Impact of poroelasticity of intraluminal thrombus on wall stress of abdominal aortic aneurysms
Conclusion: At steady state, the biphasic ILT behaves like a single-phase material in an AAA model. Consequently, computational efficient FE single-phase models, as they have been exclusively used in the past, accurately predict the wall stress in AAA models.
Source: BioMedical Engineering OnLine - August 29, 2012 Category: Biomedical Engineering Authors: Stanislav PolzerChristian GasserBernd MarkertJiri BursaPavel Skacel Source Type: research

Pulse Inversion Chirp Coded Tissue Harmonic Imaging (PI-CTHI) of Zebrafish Heart Using High Frame Rate Ultrasound Biomicroscopy.
Abstract This paper reports a pulse inversion chirp coded tissue harmonic imaging (PI-CTHI) method for visualizing small animal hearts that provides fine spatial resolution at a high frame rate without sacrificing the echo signal to noise ratio (eSNR). A 40 MHz lithium niobate (LiNbO(3)) single element transducer is employed to evaluate the performance of PI-CTHI by scanning tungsten wire targets, spherical anechoic voids, and zebrafish hearts. The wire phantom results show that PI-CTHI improves the eSNR by 4 dB from that of conventional pulse inversion tissue harmonic imaging (PI-THI), while still maintaining a ...
Source: Annals of Biomedical Engineering - August 29, 2012 Category: Biomedical Engineering Authors: Park J, Huang Y, Chen R, Lee J, Cummins TM, Zhou Q, Lien CL, Shung KK Tags: Ann Biomed Eng Source Type: research

University of Memphis awarded grant to design mobility devices
The University of Memphis has received a five-year $111,490 grant from the National Science Foundation to design custom devices for people with mobility issues. The grant will be overseen by Joel Bumgardner, professor of biomedical engineering at the university, and will help fund research in the biomedical, mechanical and electrical engineering fields. Students will work to design custom devices for people with mobility issues, specifically people who may not be able to afford those devices. In…
Source: bizjournals.com Health Care:Hospitals headlines - August 28, 2012 Category: Hospital Management Authors: Michael Sheffield Source Type: research

Morphological changes, chitinolytic enzymes and hydrophobin-like proteins as responses of Lecanicillium lecanii during growth with hydrocarbon.
Abstract Lecanicillium lecanii, Verticillium chlamydosporium, V. fungicola var flavidum and Beauveria bassiana were evaluated on their growth with pure n-hexane, toluene and n-hexane:toluene 17:83 (v:v) mixture. Another set of treatments were conducted with colloidal chitin as additional carbon source. All the strains of Lecanicillium were able to grow using hydrocarbons with or without the addition of chitin, although the presence of hydrocarbons showed significant inhibition evidenced by measured biomass, radial growth and microscopic analyses. Degradation of n-hexane ranged within 43 and 62 ...
Source: Bioprocess and Biosystems Engineering - August 28, 2012 Category: Biomedical Engineering Authors: Rocha-Pino Z, Marín-Cervantes MD, Martínez-Archundia M, Soriano-Blancas E, Revah S, Shirai K Tags: Bioprocess Biosyst Eng Source Type: research

Magnetic resonance imaging-based relationships between neck muscle cross-sectional area and neck circumference for adults and children
Conclusions The cross-sectional area and the power-law functions determined by the data in this study provide a means of calculating muscle cross-sectional area for young children, where such data are currently unavailable. This will provide an opportunity to develop more representative pediatric neck models. Content Type Journal ArticleCategory Original ArticlePages 1-7DOI 10.1007/s00586-012-2482-xAuthors Renée M. Dawson, Department of Biomedical Engineering, Wayne State University, 818W. Hancock, Detroit, MI 48201, USAZahid Latif, Department of Radiology, Wayne State University, Detroit, MI 48201...
Source: European Spine Journal - August 27, 2012 Category: Orthopaedics Tags: European Spine Journal Source Type: research

Low-level laser therapy in experimental model of collagenase-induced tendinitis in rats: effects in acute and chronic inflammatory phases
Abstract A variety of treatments for tendinopathies is currently used or has been trialed. However, in fact, there is a remarkably little evidence that any conventional therapies are effective. In the last years, low-level laser therapy (LLLT) has been showing interesting results in inflammatory modulation in different musculoskeletal disorders, but the optimal parameters and mechanisms behind these effects are not fully understood. The aim of this study is to investigate if the LLLT modulates the acute and chronic phase of collagenase-induced tendinitis in rat by interfering in mRNA expression for matrix me...
Source: Lasers in Medical Science - August 27, 2012 Category: Laser Surgery Tags: Lasers in Medical Science Source Type: research

The helical flow pump with a hydrodynamic levitation impeller
Abstract The helical flow pump (HFP) is a novel rotary blood pump invented for developing a total artificial heart (TAH). The HFP with a hydrodynamic levitation impeller, which consists of a multi-vane impeller involving rotor magnets, stator coils at the core position, and double helical-volute pump housing, was developed. Between the stator and impeller, a hydrodynamic bearing is formed. Since the helical volutes are formed at both sides of the impeller, blood flows with a helical flow pattern inside the pump. The developed HFP showed maximum output of 19 l/min against 100 mmHg of pressure head a...
Source: Journal of Artificial Organs - August 27, 2012 Category: Transplant Surgery Tags: Journal of Artificial Organs Source Type: research

Effect of layer heterogeneity on the biomechanical properties of ascending thoracic aortic aneurysms
This study addressed layer-specific differences in the biomechanical response of ascending aortic aneusysms, obtained from patients during graft replacement. Tensile tests were conducted on pairs of (orthogonally directed) intimal, medial, and adventitial strips from the anterior, posterior, and two lateral quadrants. The experimental data were reduced by the Fung-type model, affording appropriate characterization of the material properties. Testing of individual layers beyond rupture disclosed their failure properties, namely their capacity to bear varying deformation and stress levels. Material parameters cqq an...
Source: Medical and Biological Engineering and Computing - August 27, 2012 Category: Biomedical Engineering Tags: Medical and Biological Engineering and Computing Source Type: research

Secure Dynamic Access Control Scheme of PHR in Cloud Computing
Abstract With the development of information technology and medical technology, medical information has been developed from traditional paper records into electronic medical records, which have now been widely applied. The new-style medical information exchange system “personal health records (PHR)” is gradually developed. PHR is a kind of health records maintained and recorded by individuals. An ideal personal health record could integrate personal medical information from different sources and provide complete and correct personal health and medical summary through the Internet or portable media under ...
Source: Journal of Medical Systems - August 27, 2012 Category: Information Technology Tags: Journal of Medical Systems Source Type: research

Survey of blood pump diaphragm damage in the NIPRO-ventricular assist device
Abstract We surveyed the incidence of blood pump diaphragm damage (rupture or crack) in the NIPRO-ventricular assist device (VAD). In the cases in which rupture or suspected blood pump crack was detected, we disassembled the pumps to visually check the condition of the diaphragm after replacement or use. Of 366 blood pumps surveyed, diaphragm damage was observed in 2.7 %. The duration of use of the blood pumps with diaphragm damage was significantly longer than that of pumps without damage. The incidence of diaphragm damage increased with longer duration of use. On the basis of these findings, blood pum...
Source: Journal of Artificial Organs - August 27, 2012 Category: Transplant Surgery Tags: Journal of Artificial Organs Source Type: research

Design and validation of the Grip-ball for measurement of hand grip strength
Abstract: The Grip-ball is a new dynamometer used to evaluate grip strength, as well as for use in home-based rehabilitation of the hand and forearm. The Grip-ball consists of pressure and temperature sensors and an electronic wireless communication system contained in an airtight ball. That can be inflated to different pressures. The device has advantages over standard dynamometers in that it looks like a simple ball, and can wirelessly communicate via Bluetooth to any compatible receiver, thus have potential to be used for clinical assessment and rehabilitation in a remote setting. The reliability and reproducibility of ...
Source: Medical Engineering and Physics - August 27, 2012 Category: Biomedical Engineering Authors: Rana Jaber, David J. Hewson, Jacques Duchêne Tags: Technical Notes Source Type: research

Erratum to: Micromachined Coulter counter for dynamic impedance study of time sensitive cells.
PMID: 22923214 [PubMed - as supplied by publisher]
Source: Biomedical Microdevices - August 26, 2012 Category: Biomedical Engineering Authors: Wu Y, Han X, Benson JD, Almasri M Tags: Biomed Microdevices Source Type: research

Fabrication of channeled scaffolds with ordered array of micro-pores through microsphere leaching and indirect Rapid Prototyping technique.
Abstract Advanced scaffold fabrication techniques such as Rapid Prototyping (RP) are generally recognized to be advantageous over conventional fabrication methods in terms architectural control and reproducibility. Yet, most RP techniques tend to suffer from resolution limitations which result in scaffolds with uncontrollable, random-size pores and low porosity, albeit having interconnected channels which is characteristically present in most RP scaffolds. With the increasing number of studies demonstrating the profound influences of scaffold pore architecture on cell behavior and overall tissue growth, a scaffold ...
Source: Biomedical Microdevices - August 26, 2012 Category: Biomedical Engineering Authors: Tan JY, Chua CK, Leong KF Tags: Biomed Microdevices Source Type: research

Effects of bioreactor hydrodynamics on the physiology of Streptomyces.
This article reviews the experimental and numerical works dedicated to the study of the coupling between bioreactor hydrodynamics and antibiotics producing Streptomyces. In a first part, the description of hydrodynamics used in these works is presented and then the main relations used. In a second part, the assumptions made in these works are discussed and put into emphasize. Lastly, the various Streptomyces physiological responses observed are detailed and compared. PMID: 22923137 [PubMed - as supplied by publisher]
Source: Bioprocess and Biosystems Engineering - August 25, 2012 Category: Biomedical Engineering Authors: Olmos E, Mehmood N, Haj Husein L, Goergen JL, Fick M, Delaunay S Tags: Bioprocess Biosyst Eng Source Type: research

Accelerating animal cell growth in perfusion mode by multivariable control: simulation studies.
This study considers the problem of manipulating in an optimal way the perfusion and bleed flow rates of a continuous culture of hybridoma cells, so as to achieve a fast transient start-up and reject potential disturbances. The proposed solution makes use of an analysis of the properties of the steady state solutions of the nonlinear dynamic model of the cell culture, and in particular the relationship between the two main limiting substrates, glucose and glutamine. The solution is implemented using extended prediction self-adaptive control. Simulation results demonstrate the approach potentiality. PMID: 22923138 [PubM...
Source: Bioprocess and Biosystems Engineering - August 25, 2012 Category: Biomedical Engineering Authors: Sbarciog M, Saraiva I, Vande Wouwer A Tags: Bioprocess Biosyst Eng Source Type: research

Microactuator device for integrated measurement of epithelium mechanics.
We present a microfabricated device with on-chip actuation for mechanical testing of single cells. An integrated immersible electrostatic actuator system is demonstrated that applies calibrated forces to cells. We conduct stretching experiments by directly applying forces to epithelial cells adhered to device surfaces functionalized with collagen. We measure mechanical properties including stiffness, hysteresis and visco-elasticity of adherent cells. PMID: 22927158 [PubMed - as supplied by publisher]
Source: Biomedical Microdevices - August 25, 2012 Category: Biomedical Engineering Authors: Mukundan V, Nelson WJ, Pruitt BL Tags: Biomed Microdevices Source Type: research

Hemodynamically Motivated Choice of Patch Angioplasty for the Performance of Carotid Endarterectomy.
The objective of this study was to investigate biomechanics of the carotid artery (CA) repaired with patch angioplasty, study the influence of patch width and location of closure on hemodynamics, and to select the optimal patch material from those commonly used. For this purpose, a mathematical model was built that accounts for fluid-structure interaction, three-dimensional arterial geometry, non-linear anisotropic mechanical properties, non-Newtonian flow and in vivo boundary conditions. This model was used to study disease-related mechanical factors in the arterial wall and blood flow for different types of patch angiopl...
Source: Annals of Biomedical Engineering - August 25, 2012 Category: Biomedical Engineering Authors: Kamenskiy AV, Mactaggart JN, Pipinos II, Gupta PK, Dzenis YA Tags: Ann Biomed Eng Source Type: research

Erratum to: Multiscale Modeling and Data Integration in the Virtual Physiological Rat Project.
PMID: 22923062 [PubMed - as supplied by publisher]
Source: Annals of Biomedical Engineering - August 25, 2012 Category: Biomedical Engineering Authors: Beard DA, Neal ML, Tabesh-Saleki N, Thompson CT, Bassingthwaighte JB, Shimoyama M, Carlson BE Tags: Ann Biomed Eng Source Type: research

Virtual human hand: model and kinematics.
This study is a first step towards a comprehensive hand simulation tool to simulate the manipulation and grasping of objects. This paper presents a novel 25 DOFs' hand skeletal model based on hand anatomy and hand kinematics: (1) joint range of motion, (2) Denavit-Hartenberg method to define the joint relationship and (3) finger workspace determination. Novelty for this hand model includes arching the palm with the four DOFs added in the carpometacarpal and wrist joints for the ring and small fingers. PMID: 22920244 [PubMed - as supplied by publisher]
Source: Computer Methods in Biomechanics and Biomedical Engineering - August 24, 2012 Category: Biomedical Engineering Authors: Peña-Pitarch E, Falguera NT, Yang JJ Tags: Comput Methods Biomech Biomed Engin Source Type: research

Torque-related changes in mechanomyographic intensity patterns for the superficial quadriceps femoris muscles.
Abstract The purpose of this study was to investigate changes in mechanomyographic (MMG) intensity patterns for the vastus lateralis (VL), rectus femoris (RF) and vastus medialis (VM) during submaximal to maximal concentric isokinetic, eccentric isokinetic and isometric muscle actions of the leg extensors. Eleven men (mean ± SD age = 20.1 ± 1.1 years) performed concentric, eccentric and isometric muscle actions of the dominant leg extensors on 3 separate days. Surface MMG signals were detected from the VL, RF and VM, processed with a wavelet analysis and examined with a trend plot. The results indicated tha...
Source: Computer Methods in Biomechanics and Biomedical Engineering - August 24, 2012 Category: Biomedical Engineering Authors: Beck TW, Stock MS, Defreitas JM Tags: Comput Methods Biomech Biomed Engin Source Type: research

Oscillatory shear stress created by fluid pulsatility versus flexed specimen configurations.
In this study, we examined and quantified the role that (i) physiologically relevant scales of pulsatility and (ii) changes in geometry as a function of specimen flexure have in creating OSS conditions. A U-shaped bioreactor capable of producing flow, stretch and flexure was modelled with housed specimens, and computational fluid dynamic simulations were performed. We found that physiologically relevant OSS can be maximised by the application of pulsatile flow to straight, non-moving specimens in a uniform manner. This finding reduces a substantial layer of complexity in dynamic HVTE protocols in which traditionally, time-...
Source: Computer Methods in Biomechanics and Biomedical Engineering - August 24, 2012 Category: Biomedical Engineering Authors: Salinas M, Schmidt DE, Libera M, Lange RR, Ramaswamy S Tags: Comput Methods Biomech Biomed Engin Source Type: research

Sorting of cargos between axons and dendrites: modelling of differences in cargo transport in these two types of neurites.
Abstract Explaining how intracellular cargos are sorted between axons and dendrites is important for a mechanistic understanding of what happens in many neurodegenerative disorders. A simple model of cargo sorting relies on differences in microtubule (MT) orientation between axons and dendrites: in mammalian neurons all MTs in axons have their plus ends directed outward while in proximal regions of dendrites the MT polarity is mixed. It can therefore be assumed that cargos that need to be driven into axons associate with kinesin motors while cargos that need to be driven into dendrites associate with dynein motors....
Source: Computer Methods in Biomechanics and Biomedical Engineering - August 24, 2012 Category: Biomedical Engineering Authors: Kuznetsov AV Tags: Comput Methods Biomech Biomed Engin Source Type: research

Determination of the material parameters of four-fibre family model based on uniaxial extension data of arterial walls.
In conclusion, the four-fibre family model of arterial walls can be determined from uniaxial extension data. Moreover, the four-fibre family six-parameter constitutive model is the best fit to the data from Chinese pulmonary arteries, and the four-fibre family eight-parameter constitutive model is the best fit to the data from Chinese thoracic aortas. PMID: 22920461 [PubMed - as supplied by publisher]
Source: Computer Methods in Biomechanics and Biomedical Engineering - August 24, 2012 Category: Biomedical Engineering Authors: Li L, Qian X, Yan S, Hua L, Zhang H, Liu Z Tags: Comput Methods Biomech Biomed Engin Source Type: research

Augmenting intraoperative ultrasound with preoperative magnetic resonance planning models for percutaneous renal access
Conclusions: The presented image guidance is feasible and promising for PRA procedure. With careful setup it can be efficient for overcoming the limitation of current US-guided PRA.
Source: BioMedical Engineering OnLine - August 24, 2012 Category: Biomedical Engineering Authors: Zhi-Cheng LiKai LiHai-Lun ZhanKen ChenJia GuLei Wang Source Type: research

An Inverse Problem Approach to Recovery of In Vivo Nanoparticle Concentrations from Thermal Image Monitoring of MR-Guided Laser Induced Thermal Therapy.
Abstract Quantification of local variations in the optical properties of tumor tissue introduced by the presence of gold-silica nanoparticles (NP) presents significant opportunities in monitoring and control of NP-mediated laser induced thermal therapy (LITT) procedures. Finite element methods of inverse parameter recovery constrained by a Pennes bioheat transfer model were applied to estimate the optical parameters. Magnetic resonance temperature imaging (MRTI) acquired during a NP-mediated LITT of a canine transmissible venereal tumor in brain was used in the presented statistical inverse problem formulation. The...
Source: Annals of Biomedical Engineering - August 24, 2012 Category: Biomedical Engineering Authors: Fuentes D, Elliott A, Weinberg JS, Shetty A, Hazle JD, Stafford RJ Tags: Ann Biomed Eng Source Type: research

Impact of acute normobaric hypoxia on regional and global myocardial function: a speckle tracking echocardiography study
Abstract Aim of this study was to evaluate the influence of normobaric hypoxia on myocardial function in healthy humans. Fourteen subjects underwent two-dimensional speckle tracking echocardiography (2D-STE) examination during normoxia and in a normobaric hypoxia chamber. Examinations were performed at rest and during bicycle exercise test. The following parameters were quantified in both atria and ventricles by 2D-STE: Global Strain (S), systolic strain rate (SRS), early (SRE) and late (SRA) diastolic strain rate. During hypoxia SRS and SRE increased significantly in both ventricles compared to baseline. The...
Source: The International Journal of Cardiovascular Imaging - August 23, 2012 Category: Radiology Tags: The International Journal of Cardiovascular Imaging (formerly Cardiac Imaging) Source Type: research

Determining the transport mechanism of an enzyme-catalytic complex metabolic network based on biological robustness.
Abstract Understanding the transport mechanism of 1,3-propanediol (1,3-PD) is of critical importance to do further research on gene regulation. Due to the lack of intracellular information, on the basis of enzyme-catalytic system, using biological robustness as performance index, we present a system identification model to infer the most possible transport mechanism of 1,3-PD, in which the performance index consists of the relative error of the extracellular substance concentrations and biological robustness of the intracellular substance concentrations. We will not use a Boolean framework but prefer a model descri...
Source: Bioprocess and Biosystems Engineering - August 23, 2012 Category: Biomedical Engineering Authors: Wang L Tags: Bioprocess Biosyst Eng Source Type: research

An open real-time tele-stethoscopy system
Conclusions: It has been shown that real-time tele-stethoscopy, together with a videoconference system that allows a remote specialist to oversee the auscultation, may be a very helpful tool in rural areas of developing countries.
Source: BioMedical Engineering OnLine - August 23, 2012 Category: Biomedical Engineering Authors: Ignacio Foche-PerezRodolfo Ramirez-PaybaGerman Hirigoyen-EmparanzaFernando Balducci-GonzalezFrancisco-Javier Simo-ReigadasJoaquin Seoane-PascualJaime Corral-PeñafielAndres Martinez-Fernandez Source Type: research