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This page shows you the most recent publications within this specialty of the MedWorm directory.

What Portion of the Soft Tissue Artefact Requires Compensation When Estimating Joint Kinematics?
When joint kinematics is analyzed using noninvasive stereophotogrammetry, movements of the skin markers relative to the underlying bone are regarded as artefacts (soft tissue artefact (STA)). Recent literature suggests that an appropriate estimation of joint kinematics may be obtained by compensating for only a portion of the STA, but no evidence for this case has been reported, and which portion of the STA should be selected remains an issue. The aim of this study was to fill this gap. A modal approach was used to represent the STA. This resulted in a series of additive components (modes) and in the possibility to select ...
Source: Journal of Biomechanical Engineering - April 25, 2015 Category: Biomedical Engineering Source Type: research

Simple microfluidic device for studying chemotaxis in response to dual gradients.
Abstract Chemotaxis is a fundamental biological process where complex chemotactic gradients are integrated and prioritized to guide cell migration toward specific locations. To understand the mechanisms of gradient dependent cell migration, it is important to develop in vitro models that recapitulate key attributes of the chemotactic cues present in vivo. Current in vitro tools for studying cell migration are not amenable to easily study the response of neutrophils to dual gradients. Many of these systems require external pumps and complex setups to establish and maintain the gradients. Here we report a simple yet ...
Source: Biomedical Microdevices - April 24, 2015 Category: Biomedical Engineering Authors: Moussavi-Harami SF, Pezzi HM, Huttenlocher A, Beebe DJ Tags: Biomed Microdevices Source Type: research

The Contribution of the Acetabular Labrum to Hip Joint Stability: A Quantitative Analysis Using a Dynamic Three-Dimensional Robot Model
The acetabular labrum provides mechanical stability to the hip joint in extreme positions where the femoral head is disposed to subluxation. We aimed to quantify the isolated labrum's stabilizing value. Five human cadaveric hips were mounted to a robotic manipulator, and subluxation potential tests were run with and without labrum. Three-dimensional (3D) kinematic data were quantified using the stability index (Colbrunn et al., 2013, “Impingement and Stability of Total Hip Arthroplasty Versus Femoral Head Resurfacing Using a Cadaveric Robotics Model,” J. Orthop. Res., 31(7), pp. 1108–1115). Global and regional stabil...
Source: Journal of Biomechanical Engineering - April 24, 2015 Category: Biomedical Engineering Source Type: research

Table of Contents
Presents the table of contents for this issue of the publication. (Source: IEEE Transactions on Signal Processing)
Source: IEEE Transactions on Signal Processing - April 24, 2015 Category: Biomedical Engineering Source Type: research

Ultrasonic Thermometry Inside Tissues Based on High-resolution Detection of Spectral Shifts in Overtones of Scattering Signals
Publication date: 2015 Source:Physics Procedia, Volume 63 Author(s): I. Bazán , A. Ramos , A. Ramírez , L. Leija Some research results of cooperation works in biomedical engineering, established among current national projects of Mexico and Spain, are resumed. They are related to coordinated activities of three R & D groups, with the aim to achieve high-resolution ultrasonic thermometry into tissue phantoms with internal reflectors of a non-invasive way. Advanced spectral techniques are being used to extract thermal information in echo-signals acquired from biological phantoms with internal structures having a ...
Source: Physics Procedia - April 24, 2015 Category: Physics Source Type: research

Wound perimeter, area, and volume measurement based on laser 3D and color acquisition
Conclusions: According to the results of verification and the fact that typical wound analysis takes 20 seconds, the method for wound shape measurement can be clinically used as a precise tool for objectively monitoring the wound healing based on measuring its 3D shape and color. (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - April 24, 2015 Category: Biomedical Engineering Authors: Urban Pavlov¿i¿Janez DiaciJanez Mo¿inaMatija Jezer¿ek Source Type: research

Model demonstrates functional purpose of the nasal cycle
Conclusions: It is quantitatively demonstrated in this work how the nasal cycle enables the upper airway to accommodate the contrasting roles of air conditioning and the removal of entrapped contaminants through fluctuation in airflow partitioning between each airway. (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - April 24, 2015 Category: Biomedical Engineering Authors: David WhiteJim BartleyRoy Nates Source Type: research

Evaluation of an open access software for calculating glucose variability parameters of a continuous glucose monitoring system applied at pediatric intensive care unit
Conclusions: The GVAP is a reliable open access program for analyzing different glycemic variability parameters, hence it could be a useful tool for the study of glycemic control among critically ill patients. (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - April 24, 2015 Category: Biomedical Engineering Authors: Gábor MaricsZsófia LendvaiCsaba LódiLevente KonczDávid ZakariásGyörgy SchusterBorbála MikosCsaba HermannAttila SzabóPéter Tóth-Heyn Source Type: research

A dual mode breath sampler for the collection of the end-tidal and dead space fractions
Exhaled air is a complex mixture of inorganic gases such as nitric oxide (NO) and carbon monoxide (CO), volatile organic compounds (VOCs) like acetone and isoprene and low or non-volatile compounds like hydrogen peroxide or cytokines solubilized in breath aerosol [1]. (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - April 24, 2015 Category: Biomedical Engineering Authors: P. Salvo, C. Ferrari, R. Persia, S. Ghimenti, T. Lomonaco, F. Bellagambi, F. Di Francesco Source Type: research

Individual variability analysis of fluorescence parameters measured in skin with different levels of nutritive blood flow
Fluorescent spectroscopy is becoming more widely used in chemistry, biology, in various fields of medical technology and medicine in general. These methods are highly sensitive and provide a unique opportunity to study the excited states of molecules, photochemical reactions, dynamics of fast molecular processes, structures, and properties of complex biochemical and cellular systems [1,2]. The FS provides effective and non-invasive optical diagnostics, primarily in medical areas such as oncology, transplantation, cosmetology and surgery [3–7]. (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - April 24, 2015 Category: Biomedical Engineering Authors: Andrey V. Dunaev, Victor V. Dremin, Evgeny A. Zherebtsov, Ilya E. Rafailov, Karina S. Litvinova, Scott G. Palmer, Neil A. Stewart, Sergei G. Sokolovski, Edik U. Rafailov Source Type: research

Envelopment filter and K-means for the detection of QRS waveforms in electrocardiogram
The electrocardiogram (ECG) is a well-established technique for determining the electrical activity of the heart and studying its diseases. It is the most common and non-invasive technique for recording heart activity. It shows the electrical activity of the myocardial contraction and mainly consists of six waves: P, Q, R, S, T, and U. The Q, R, and S waves determine the most important complex of this signal, because it can show different abnormalities, helping to detect pathologies. These waveforms, their shapes and the time of their occurrence, give us important information about the state of the heart, such as premature...
Source: Medical Engineering and Physics - April 23, 2015 Category: Biomedical Engineering Authors: Manuel Merino, Isabel María Gómez, Alberto J. Molina Tags: Technical note Source Type: research

Design of an actively controlled steerable needle with tendon actuation and FBG-based shape sensing
Needles form a minimally invasive alternative to reach deep seated locations within the human body for diagnosis and treatment of diseased tissue. In most of these treatments, e.g. taking a liver biopsy or thermally ablating malignant structures by means of radio frequency ablation, an accurate tip placement is of importance. The operator often works with visual feedback from computed tomography (CT) or ultrasound (US) devices. Nevertheless, the risk of needle misplacement tends to increase with target depth. (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - April 23, 2015 Category: Biomedical Engineering Authors: Nick J. van de Berg, Jenny Dankelman, John J. van den Dobbelsteen Tags: Technical note Source Type: research

Drill wear monitoring in cortical bone drilling
Along with the development of new surgical approaches and techniques, bone drilling has become mostly routine and continuously increasing medical intervention. Bone tissue is formed by organic and mineral phases whose interactions result in complex mechanical and thermal properties. All bone drilling interventions include heat generation due to the friction between tool, bone and chips, which can significantly influence the post-operative recovery. Hence, novel drilling techniques have been used to study the interaction between the drill and bone in order to reduce drilling forces and improve chip removal from the drilling...
Source: Medical Engineering and Physics - April 23, 2015 Category: Biomedical Engineering Authors: Tomislav Staroveski, Danko Brezak, Toma Udiljak Source Type: research

Finite element analysis predicts experimental failure patterns in vertebral bodies loaded via intervertebral discs up to large deformation
Vertebral compression fractures are associated with increased risk of subsequent fractures, pain, decreased quality of life, and mortality [1,2] and the risk of such fractures increases with age [3]. Dual energy X-ray absorptiometry (DXA) is currently used to estimate fracture risk clinically; however, it cannot accurately identify individuals who will suffer a fracture [4] and does not account for three-dimensional geometry or local changes in bone density and orientation. Patient-specific nonlinear finite element models based on quantitative computed tomography (QCT) are able to predict vertebral strength more accurately...
Source: Medical Engineering and Physics - April 23, 2015 Category: Biomedical Engineering Authors: Allison L. Clouthier, Hadi S. Hosseini, Ghislain Maquer, Philippe K. Zysset Tags: Technical note Source Type: research

Editorial Board
(Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - April 22, 2015 Category: Biomedical Engineering Source Type: research

NIH funds WPI study aimed at engineering more natural and durable replacement heart valves
(Worcester Polytechnic Institute) With a $450,000, three-year award from the National Institutes of Health, a team at Worcester Polytechnic Institute led by Kristen Billiar, Ph.D., professor of biomedical engineering, will analyze how mechanical forces and cellular growth factors affect the growth and development of human heart valves to advance the long-term goal of developing a new class of tissue-engineered heart valves that are more natural and longer-lasting than current replacement valves. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 22, 2015 Category: Global & Universal Source Type: news

Enhanced L-lysine production from pretreated beet molasses by engineered Escherichia coli in fed-batch fermentation.
Abstract Faster sugar consumption rate and low-cost nitrogen source are required for the chemical biosynthesis using molasses. Five pretreatment methods were applied to beet molasses prior to fermentation through engineered Escherichia coli, respectively, and corn steep liquid was used as an organic nitrogen source to replace expensive yeast extract. Furthermore, the effects of different feeding strategy in fed-batch fermentation on L-lysine production were investigated. The experimental results showed that combined tricalcium phosphate, sulfuric acid, and activated carbon pretreatment method (TPSA) pretreatment co...
Source: Bioprocess and Biosystems Engineering - April 22, 2015 Category: Biomedical Engineering Authors: He X, Chen K, Li Y, Wang Z, Zhang H, Qian J, Ouyang P Tags: Bioprocess Biosyst Eng Source Type: research

Commentary on: "In Vivo Remodelling of Vascularizing Engineered Tissues".
PMID: 25900278 [PubMed - as supplied by publisher] (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - April 22, 2015 Category: Biomedical Engineering Authors: Dean Chamberlain M, West ME, Lam GC, Sefton MV Tags: Ann Biomed Eng Source Type: research

Diffusion LMS Over Multitask Networks
The diffusion LMS algorithm has been extensively studied in recent years. This efficient strategy allows to address distributed optimization problems over networks in the case where nodes have to collaboratively estimate a single parameter vector. Nevertheless, there are several problems in practice that are multitask-oriented in the sense that the optimum parameter vector may not be the same for every node. This brings up the issue of studying the performance of the diffusion LMS algorithm when it is run, either intentionally or unintentionally, in a multitask environment. In this paper, we conduct a theoretical analysis ...
Source: IEEE Transactions on Signal Processing - April 21, 2015 Category: Biomedical Engineering Source Type: research

IEEE Transactions on Biomedical Engineering Handling Editors
Presents a directory and listing of the associate editors and board members for this issue of the publication. (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - April 21, 2015 Category: Biomedical Engineering Source Type: research

2015 IEEE Nuclear Science Symposium & Medical imaging Conference
Prospective authors are requested to submit new, unpublished manuscripts for inclusion in the upcoming event described in this call for papers. (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - April 21, 2015 Category: Biomedical Engineering Source Type: research

9th IEEE-EMBS International Summer School on Biomedical Signal Processing
Prospective authors are requested to submit new, unpublished manuscripts for inclusion in the upcoming event described in this call for papers. (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - April 21, 2015 Category: Biomedical Engineering Source Type: research

IEEE Transactions on Biomedical Engineering information for authors
These instructions give guidelines for preparing papers for this publication. Presents information for authors publishing in this journal. (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - April 21, 2015 Category: Biomedical Engineering Source Type: research

Modeling and Estimation of Tip Contact Force for Steerable Ablation Catheters
Conclusion: The proposed kinematic model and the force estimation technique can be implemented together to describe the catheter's behavior before contact, detect tip/tissue contact, and determine the range of contact forces. Significance: This study proves that the flexibility of the catheter's distal shaft provide- a means of estimating the force exerted on tissue by the ablation tip. (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - April 21, 2015 Category: Biomedical Engineering Source Type: research

An Integrated Widefield Imaging and Spectroscopy System for Contrast-Enhanced, Image-Guided Resection of Tumors
Conclusion: These results demonstrate a unique concept in image-guided surgery by combining local excitation and spectroscopy with widefield imaging. Significance: The ability to readily detect ICG in canines with spontaneous tumors in a clinical setting exemplifies the potential for further clinical translation; the promising results of detecting neoplasia on the marginal specimen surface underscore the clinical utility. (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - April 21, 2015 Category: Biomedical Engineering Source Type: research

Motion Robust Remote-PPG in Infrared
In this study, we investigate the feasibility of rPPG in the (near)-infrared spectrum, which broadens the scope of applications for rPPG. Two camera setups are investigated: one setup consisting of three monochrome cameras with different optical filters, and one setup consisting of a single RGB camera with a visible light blocking filter. Simulation results predict the monochrome setup to be more motion robust, but this simulation neglects parallax. To verify this, a challenging benchmark dataset consisting of 30 videos is created with various motion scenarios and skin tones. Experiments show that both camera setups are ca...
Source: IEEE Transactions on Biomedical Engineering - April 21, 2015 Category: Biomedical Engineering Source Type: research

Real-Time Closed-Loop Control of Human Heart Rate and Blood Pressure
Prolonged bed rest has significant negative impacts on the human body, particularly on the cardiovascular system. To overcome adverse effects and enhance functional recovery in bedridden patients, the goal is to mobilize patients as early as possible while controlling and stabilizing their cardiovascular system. In this paper, we used a robotic tilt table that allows early mobilization by modulating body inclination and automated leg movement to control the cardiovascular variables heart rate (HR) or systolic or diastolic blood pressures (sBP, dBP). The design and use of a control system is often done with a simulation mod...
Source: IEEE Transactions on Biomedical Engineering - April 21, 2015 Category: Biomedical Engineering Source Type: research

Extraction of Time and Frequency Features From Grip Force Rates During Dexterous Manipulation
In this study, we addressed these questions by validating and applying two computational approaches to extract features from GFR in humans: 1) fitting a Gaussian function to GFR and quantifying the goodness of the fit [root-mean-square error, (RMSE)]; and 2) continuous wavelet transform (CWT), where we assessed the correlation of the GFR signal with a Mexican Hat function. Experiment 1 consisted of a classic pseudorandomized presentation of object mass (light or heavy), where grip forces developed to lift a mass heavier than expected are known to exhibit corrective responses. For Experiment 2, we applied our ...
Source: IEEE Transactions on Biomedical Engineering - April 21, 2015 Category: Biomedical Engineering Source Type: research

Evaluation of Peritoneal Microbubble Oxygenation Therapy in a Rabbit Model of Hypoxemia
This study addressed the need to scale up the procedure to a larger animal with a splanchnic cardiac output similar to humans. Our results show that PMO therapy can double the survival time of rabbits experiencing complete tracheal occlusion from $6.6 pm 0.6$ min for the saline controls to $12.2 pm 3.0$ min for the bolus PMO-treated cohort. Additionally, we designed and tested a new peritoneal delivery system to circulate OMBs through the peritoneal cavity. Circulation achieved a similar survival benefit to bolus delivery under these conditions. Overall, these results support the feasibility of the PMO technology to provid...
Source: IEEE Transactions on Biomedical Engineering - April 21, 2015 Category: Biomedical Engineering Source Type: research

Autonomous Unobtrusive Detection of Mild Cognitive Impairment in Older Adults
This study is of great significance since it can potentially assist in the early detection of cognitive impairment in older adults. (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - April 21, 2015 Category: Biomedical Engineering Source Type: research

Sparse Dissimilarity-Constrained Coding for Glaucoma Screening
Conclusion: The proposed method achieves good accuracy for glaucoma detection. Significance: The method has a great potential to be used for large-scale population-based glaucoma screening. (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - April 21, 2015 Category: Biomedical Engineering Source Type: research

An Inductive Sensor for Real-Time Measurement of Plantar Normal and Shear Forces Distribution
Conclusion: With its high resolution, high sensitivity, and the capability of monitoring forces at different positions of a foot simultaneously, this sensor can be potentially used for real-time measurement of plantar normal force and shear forces distribution on diabetes patient's foot. Significance: Real-time monitoring of the normal force and shear forces on diabetes patient's foot can provide useful information for physicians and diabetes patients to take actions in preventing foot ulceration. (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - April 21, 2015 Category: Biomedical Engineering Source Type: research