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This page shows you the most recent publications within this specialty of the MedWorm directory.

Bilinear Generalized Approximate Message Passing—Part II: Applications
In this paper, we extend the generalized approximate message passing (G-AMP) approach, originally proposed for high-dimensional generalized-linear regression in the context of compressive sensing, to the generalized-bilinear case. In Part I of this two-part paper, we derived our Bilinear G-AMP (BiG-AMP) algorithm as an approximation of the sum-product belief propagation algorithm in the high-dimensional limit, and proposed an adaptive damping mechanism that aids convergence under finite problem sizes, an expectation-maximization (EM)-based method to automatically tune the parameters of the assumed priors, and two rank-sele...
Source: IEEE Transactions on Signal Processing - October 24, 2014 Category: Biomedical Engineering Source Type: research

Data Predistortion for Multicarrier Satellite Channels Based on Direct Learning
Satellite communication is facing the urgent need of improving data rate and efficiency to compete with the quality of service offered by terrestrial communication systems. An imminent gain, achievable without the need of upgrading current satellite technology, can be obtained by exploiting multicarrier operation at the transponder and using highly efficient modulation schemes. However, on-board multicarrier joint amplification of high order modulation schemes is a critical operation as it brings severe non-linear distortion effects. These distortions increase as the on-board High Power Amplifier (HPA) is operated to yield...
Source: IEEE Transactions on Signal Processing - October 24, 2014 Category: Biomedical Engineering Source Type: research

Matched-Field Processing Performance Under the Stochastic and Deterministic Signal Models
Matched-field processing (MFP) is commonly used in underwater acoustics to estimate source position and/or oceanic environmental parameters. Performance prediction of the multisnapshot and multifrequency MFP problem is of critical importance. To this end, two signal models are usually considered: the stochastic model, which assumes that the source signal is a stochastic process, and the deterministic model, which assumes that the source signal is a deterministic quantity. The Ziv–Zakai bound (ZZB) and the method of interval errors (MIE), which both rely on the computation of a so-called pairwise error probability, p...
Source: IEEE Transactions on Signal Processing - October 24, 2014 Category: Biomedical Engineering Source Type: research

Bilinear Generalized Approximate Message Passing—Part I: Derivation
In this paper, we extend the generalized approximate message passing (G-AMP) approach, originally proposed for high-dimensional generalized-linear regression in the context of compressive sensing, to the generalized-bilinear case, which enables its application to matrix completion, robust PCA, dictionary learning, and related matrix-factorization problems. Here, in Part I of a two-part paper, we derive our Bilinear G-AMP (BiG-AMP) algorithm as an approximation of the sum-product belief propagation algorithm in the high-dimensional limit, where central-limit theorem arguments and Taylor-series approximations apply, and unde...
Source: IEEE Transactions on Signal Processing - October 24, 2014 Category: Biomedical Engineering Source Type: research

Single-Carrier Equalization for Asynchronous Two-Way Relay Networks
We consider an asynchronous bi-directional amplify-and-forward relay network, where two single-antenna transceivers communicate with the help of several single-antenna relay nodes using a single-carrier communication scheme. The propagation delay of each relaying path, (which originates from one transceiver, goes through a certain relay, and ends at the other transceiver) is assumed to be different from those of the other relaying paths. This assumption turns the end-to-end link into a frequency selective channel which can have multiple taps. As such, intersymbol interference (ISI) is inevitable at the two transceivers. As...
Source: IEEE Transactions on Signal Processing - October 24, 2014 Category: Biomedical Engineering Source Type: research

Distributed Asynchronous Optimization Framework for the MISO Interference Channel
We study the distributed optimization of transmit strategies in a multiple-input, single-output (MISO) interference channel (IFC). Existing distributed algorithms rely on strictly synchronized update steps by the individual users. They require a global synchronization mechanism and potentially suffer from the synchronization penalty caused by e.g., backhaul communication delays and fixed update sequences. We establish a general optimization framework that allows asynchronous update steps. The users perform their computations at arbitrary instants of time and do not wait for information that has been sent to them. Based on ...
Source: IEEE Transactions on Signal Processing - October 24, 2014 Category: Biomedical Engineering Source Type: research

Bright field microscopic cells counting method for BEVS using nonlinear convergence index sliding band filter
Conclusion: Results suggest the proposed TSBF method can detect insect cells with low error rate, and it is suitable for the counting task in BEVS to take the place of manual counting by humans. Growth curve results can reflect the cells' growth manner, which was generated by our proposed TSBF method in this paper can reflected the similar manner with it's from the manual method. All of these proven that the proposed insect cell counting method can clearly improve the efficiency of BEVS. (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - October 24, 2014 Category: Biomedical Engineering Authors: Dong SuiKuanquan WangHeemin ParkJinseok Chae Source Type: research

The Assessment of the Spinal Curvatures in the Sagittal Plane of Children Using an Ultrasound-Based Motion Analysing System.
Abstract In children's posture examinations the question often arises whether an X-ray examination is necessary or appropriate. On screening and in other cases when X-ray is contraindicated, alternative-non-invasive-examinations are available. To measure the shapes of the children's spines beside the Spinal Mouse also the Zebris ultrasound-based spine measuring instrument is accessible and nowadays commonly used. The main aim of the study is to determine the shape of the school-age children's spines in the sagittal plane with an alternative, non-invasive, radiation-free measuring method. From the results calculated...
Source: Annals of Biomedical Engineering - October 22, 2014 Category: Biomedical Engineering Authors: Takács M, Rudner E, Kovács A, Orlovits Z, Kiss RM Tags: Ann Biomed Eng Source Type: research

Estimation of pelvis kinematics in level walking based on a single inertial sensor positioned close to the sacrum: validation on healthy subjects with stereophotogrammetric system
Conclusions: These results suggest that this inertial device is a reliable alternative to stereophotogrammetric systems for pelvis kinematics measurements, in addition to being easier to use and cheaper. The device can provide to the patient and to the examiner reliable feedback in real-time during routine clinical tests. (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - October 21, 2014 Category: Biomedical Engineering Authors: Francesca BuganèMaria BenedettiValentina D¿AngeliAlberto Leardini Source Type: research

Lipid production by microalgae Chlorella protothecoides with volatile fatty acids (VFAs) as carbon sources in heterotrophic cultivation and its economic assessment.
Abstract Volatile fatty acids (VFAs) that can be derived from food wastes were used for microbial lipid production by Chlorella protothecoides in heterotrophic cultures. The usage of VFAs as carbon sources for lipid accumulation was investigated in batch cultures. Culture medium, culture temperature, and nitrogen sources were explored for lipid production in the heterotrophic cultivation. The concentration and the ratio of VFAs exhibited significant influence on cell growth and lipid accumulation. The highest lipid yield coefficient and lipid content of C. protothecoides grown on VFAs were 0.187 g/g and 48.7 %, ...
Source: Bioprocess and Biosystems Engineering - October 21, 2014 Category: Biomedical Engineering Authors: Fei Q, Fu R, Shang L, Brigham CJ, Chang HN Tags: Bioprocess Biosyst Eng Source Type: research

Zirconia-based dental crown to support a removable partial denture: a three-dimensional finite element analysis using contact elements and micro-CT data.
Abstract Veneer fracture is the most common complication in zirconia-based restorations. The aim of this study was to evaluate the mechanical behavior of a zirconia-based crown in a lower canine tooth supporting removable partial denture (RPD) prosthesis, varying the bond quality of the veneer/coping interface. Microtomography (μCT) data of an extracted left lower canine were used to build the finite element model (M) varying the core material (gold core - MAu; zirconia core - MZi) and the quality of the veneer/core interface (complete bonded - MZi; incomplete bonded - MZi-NL). The incomplete bonding condition was...
Source: Computer Methods in Biomechanics and Biomedical Engineering - October 21, 2014 Category: Biomedical Engineering Authors: Rocha EP, Anchieta RB, de Almeida EO, Freitas AC, Martini AP, Sotto-Maior BS, Luersen MA, Ko CC Tags: Comput Methods Biomech Biomed Engin Source Type: research

Time Evolution of Deformation in a Human Cartilage Under Cyclic Loading.
Abstract Recent imaging has revealed that in vivo contact deformations of human knee cartilage under physiological loadings are surprisingly large-typically on the order of 10%, but up to 20 or 30% of tibiofemora cartilage thickness depending on loading conditions. In this paper we develop a biphasic, large deformation, non-linear poroelastic model of cartilage that can accurately represent the time dependence and magnitude of cyclic cartilage deformations in vivo. The model takes into account cartilage tension-compression nonlinearity and a new constitutive relation in which the compressive stiffness and hydraulic...
Source: Annals of Biomedical Engineering - October 21, 2014 Category: Biomedical Engineering Authors: Zhang L, Miramini S, Smith DW, Gardiner BS, Grodzinsky AJ Tags: Ann Biomed Eng Source Type: research

Preparation of Chitosan/Hydroxyapatite Substrates with Controllable Osteoconductivity Tracked by AFM.
In this study, cell-material adhesive strength and cellular mechanical properties were measured using atomic force microscopy (AFM) to track cell attachment and osteogenic differentiation. First, chitosan substrates were treated with simulated body fluid (SBF) for various periods, resulting in substrates with different osteoconductivity. The X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDS) and in vitro tests revealed that the biomimeticity and osteoconductivity of substrates increased with increasing time of SBF treatment. When the SBF immersion exceeded 14 days, the chitosan substrates exhibited their ...
Source: Annals of Biomedical Engineering - October 21, 2014 Category: Biomedical Engineering Authors: Ho MH, Li CH, Hsiao SW, Thien DV Tags: Ann Biomed Eng Source Type: research

Emergence of Scaffold-Free Approaches for Tissue Engineering Musculoskeletal Cartilages.
Abstract This review explores scaffold-free methods as an additional paradigm for tissue engineering. Musculoskeletal cartilages-for example articular cartilage, meniscus, temporomandibular joint disc, and intervertebral disc-are characterized by low vascularity and cellularity, and are amenable to scaffold-free tissue engineering approaches. Scaffold-free approaches, particularly the self-assembling process, mimic elements of developmental processes underlying these tissues. Discussed are various scaffold-free approaches for musculoskeletal cartilage tissue engineering, such as cell sheet engineering, aggregation,...
Source: Annals of Biomedical Engineering - October 21, 2014 Category: Biomedical Engineering Authors: DuRaine GD, Brown WE, Hu JC, Athanasiou KA Tags: Ann Biomed Eng Source Type: research

Macrophages Modulate Engineered Human Tissues for Enhanced Vascularization and Healing.
Abstract Tissue engineering is increasingly based on recapitulating human physiology, through integration of biological principles into engineering designs. In spite of all progress in engineering functional human tissues, we are just beginning to develop effective methods for establishing blood perfusion and controlling the inflammatory factors following implantation into the host. Functional vasculature largely determines tissue survival and function in vivo. The inflammatory response is a major regulator of vascularization and overall functionality of engineered tissues, through the activity of different types o...
Source: Annals of Biomedical Engineering - October 21, 2014 Category: Biomedical Engineering Authors: Spiller KL, Freytes DO, Vunjak-Novakovic G Tags: Ann Biomed Eng Source Type: research

Mechanical and dynamic characteristics of encapsulated microbubbles coupled by magnetic nanoparticles as multifunctional imaging and drug delivery agents.
Abstract Development of magnetic encapsulated microbubble agents that can integrate multiple diagnostic and therapeutic functions is a key focus in both biomedical engineering and nanotechnology and one which will have far-reaching impact on medical diagnosis and therapies. However, properly designing multifunctional agents that can satisfy particular diagnostic/therapeutic requirements has been recognized as rather challenging, because there is a lack of comprehensive understanding of how the integration of magnetic nanoparticles to microbubble encapsulating shells affects their mechanical properties and dynamic p...
Source: Physica Medica - October 20, 2014 Category: Physics Authors: Guo G, Lu L, Yin L, Tu J, Guo X, Wu J, Xu D, Zhang D Tags: Phys Med Biol Source Type: research

Gluconic acid production from sucrose in an airlift reactor using a multi-enzyme system.
Abstract Sucrose from sugarcane is produced in abundance in Brazil, which provides an opportunity to manufacture other high-value products. Gluconic acid (GA) can be produced by multi-enzyme conversion of sucrose using the enzymes invertase, glucose oxidase, and catalase. In this process, one of the byproducts is fructose, which has many commercial applications. This work concerns the batch mode production of GA in an airlift reactor fed with sucrose as substrate. Evaluation was made of the influence of temperature and pH, as well as the thermal stability of the enzymes. Operational conditions of 40 °C and pH 6.0...
Source: Bioprocess and Biosystems Engineering - October 19, 2014 Category: Biomedical Engineering Authors: Mafra AC, Furlan FF, Badino AC, Tardioli PW Tags: Bioprocess Biosyst Eng Source Type: research

Editorial: controlled release and drug delivery in diseases.
Abstract Designing therapeutic agents requires receptor targeting and drug delivery for optimal medication to improve health. Although innovative strategies help drug delivery, many therapeutic agents have side effects due to nonspecific binding. Biomedical engineering aims to target the therapeutic agents in controlled release over an extended period of time at specific rate to a targeted location of the body. Generally, administering engineered particles affect organ locally and this process reduces or eliminates the side effects compared to systemic drug delivery [1, 2]. This thematic issue reports recent develo...
Source: Protein and Peptide Letters - October 18, 2014 Category: Biochemistry Authors: Tutar Y Tags: Protein Pept Lett Source Type: research

An equivalent circuit model for onset and offset exercise response
Conclusions: Compared with existing works, this model can accommodate the different exercise strengths at bothonset and offset of exercise, while also depicting human onset and offset exercise responses, and guaranteethe continuity of outputs during onset-offset switching. A unique adaption feature by allowingthe time constant and steady state gain to re-shift back to their original states, more closely mimicsthe different exercise strengths during normal daily exercise activities. (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - October 18, 2014 Category: Biomedical Engineering Authors: Yi ZhangAzzam HaddadSteven SuBranko CellerAaron CouttsRob DuffieldCheyne DongesHung Nguyen Source Type: research

Development of an efficient process intensification strategy for enhancing Pfu DNA polymerase production in recombinant Escherichia coli.
Abstract An efficient induction strategy that consisted of multiple additions of small doses of isopropyl-β-D-thiogalactopyranoside (IPTG) in the early cell growth phase was developed for enhancing Pfu DNA polymerase production in Escherichia coli. In comparison to the most commonly used method of a single induction of 1 mM IPTG, the promising induction strategy resulted in an increase in the Pfu activity of 13.5 % in shake flasks, while simultaneously decreasing the dose of IPTG by nearly half. An analysis of the intracellular IPTG concentrations indicated that the cells need to maintain an optimum intracellula...
Source: Bioprocess and Biosystems Engineering - October 18, 2014 Category: Biomedical Engineering Authors: Hu JH, Wang F, Liu CZ Tags: Bioprocess Biosyst Eng Source Type: research

High-productivity lipid production using mixed trophic state cultivation of Auxenochlorella (Chlorella) protothecoides.
Abstract A mixed trophic state production process for algal lipids for use as feedstock for renewable biofuel production was developed and deployed at subpilot scale using a green microalga, Auxenochlorella (Chlorella) protothecoides. The process is composed of two separate stages: (1) the photoautotrophic stage, focused on biomass production in open ponds, and (2) the heterotrophic stage focused on lipid production and accumulation in aerobic bioreactors using fixed carbon substrates (e.g., sugar). The process achieved biomass and lipid productivities of 0.5 and 0.27 g/L/h that were, respectively, over 250 and 67...
Source: Bioprocess and Biosystems Engineering - October 18, 2014 Category: Biomedical Engineering Authors: Rismani-Yazdi H, Hampel KH, Lane CD, Kessler BA, White NM, Moats KM, Thomas Allnutt FC Tags: Bioprocess Biosyst Eng Source Type: research

Continuous degradation of maltose: improvement in stability and catalytic properties of maltase (α-glucosidase) through immobilization using agar-agar gel as a support.
Abstract Maltose degrading enzyme was immobilized within agar-agar support via entrapment method due to its industrial utilization. The maximum immobilization efficiency (82.77 %) was achieved using 4.0 % agar-agar keeping the diameter of bead up to 3.0 mm. The matrix entrapment showed maximum catalytic activity at pH 7.0 and temperature 65 °C. Substrate saturation kinetics showed that the K m of immobilized enzyme increased from 1.717 to 2.117 mM ml(-1) where as Vmax decreased from 8,411 to 7,450 U ml(-1 )min(-1) as compared to free enzyme. The immobilization significantly increased the stability of malt...
Source: Bioprocess and Biosystems Engineering - October 18, 2014 Category: Biomedical Engineering Authors: Nawaz MA, Karim A, Aman A, Marchetti R, Qader SA, Molinaro A Tags: Bioprocess Biosyst Eng Source Type: research

Improvement of catalytic activity of lipase in the presence of calix[4]arene valeric acid or hydrazine derivative.
Abstract Sol-gel encapsulation is a simple but powerful method to enhance the enantioselectivity of lipase-catalyzed transformations in an isooctane/aqueous buffer solution. Candida rugosa lipase was encapsulated according to a sol-gel procedure in the presence and absence of calix[4]arene hydrazine or carboxylic acid derivatives with Fe3O4 magnetic nanoparticles as an additive. The activity of the encapsulated lipases was evaluated for the enantioselective hydrolysis of racemic Naproxen methyl ester and the hydrolysis of p-Nitrophenylpalmitate. The results indicate that the encapsulated lipase without calix[4]aren...
Source: Bioprocess and Biosystems Engineering - October 18, 2014 Category: Biomedical Engineering Authors: Akoz E, Sayin S, Kaplan S, Yilmaz M Tags: Bioprocess Biosyst Eng Source Type: research

Ultrasound Technologies for Biomaterials Fabrication and Imaging.
Abstract Ultrasound is emerging as a powerful tool for developing biomaterials for regenerative medicine. Ultrasound technologies are finding wide-ranging, innovative applications for controlling the fabrication of bioengineered scaffolds, as well as for imaging and quantitatively monitoring the properties of engineered constructs both during fabrication processes and post-implantation. This review provides an overview of the biomedical applications of ultrasound for imaging and therapy, a tutorial of the physical mechanisms through which ultrasound can interact with biomaterials, and examples of how ultrasound tec...
Source: Annals of Biomedical Engineering - October 18, 2014 Category: Biomedical Engineering Authors: Dalecki D, Hocking DC Tags: Ann Biomed Eng Source Type: research

Head Injury Potential and the Effectiveness of Headgear in Women's Lacrosse.
Abstract Over the past 10 years, lacrosse has grown increasingly popular, making it one of the fastest growing team sports in the country. Similar to other sporting activities, head injuries in lacrosse can and do occur, and the number of lacrosse-related head injuries has increased in recent years. In women's lacrosse, protective headgear is not required, but U.S. Lacrosse and the American Society for Testing and Materials are currently working to develop a headgear standard for the women's game. In the interim, some female lacrosse programs and individual players are wearing soft headgear during play. The effect...
Source: Annals of Biomedical Engineering - October 18, 2014 Category: Biomedical Engineering Authors: Rodowicz KA, Olberding JE, Rau AC Tags: Ann Biomed Eng Source Type: research

In Vitro Biomechanical Evaluation of Single Impulse and Repetitive Mechanical Shockwave Devices Utilized for Spinal Manipulative Therapy.
The objectives of this study were to determine the ability of several commercial shockwave devices to achieve a desired thrust profile in a benchtop setting, determine the thrust profile in a clinical analog, and determine the influence of operator experience level on device performance. We conducted two different types of testing: (1) bench testing to evaluate the devices themselves, and (2) clinical equivalent testing to determine the influence of the operator. The results indicated a significant dependence of thrust output on the compliance of the test media. The Activator V-E device matched the ideal half-sine thrust p...
Source: Annals of Biomedical Engineering - October 18, 2014 Category: Biomedical Engineering Authors: Liebschner MA, Chun K, Kim N, Ehni B Tags: Ann Biomed Eng Source Type: research

IEEE Transactions on Industrial Electronics publication information
(Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - October 17, 2014 Category: Biomedical Engineering Source Type: research

IEEE Transactions on Biomedical Engineering information for authors
Provides instructions and guidelines to prospective authors who wish to submit manuscripts. (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - October 17, 2014 Category: Biomedical Engineering Source Type: research

Corrections to “Breast Cancer Histopathology Image Analysis: A Review”
(Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - October 17, 2014 Category: Biomedical Engineering Source Type: research

EMBC 2015 Milano
(Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - October 17, 2014 Category: Biomedical Engineering Source Type: research

Corrections to “Predicting Free-Living Energy Expenditure Using a Miniaturized Ear-Worn Sensor: An Evaluation Against Doubly Labeled Water”
Accurate estimation of daily total energy expenditure (EE) is a prerequisite for assisted weight management and assessing certain health conditions. The use of wearable sensors for predicting free-living EE is challenged by consistent sensor placement, user compliance, and estimation methods used. This paper examines whether a single ear-worn accelerometer can be used for EE estimation under free-living conditions. An EE prediction model as first derived and validated in a controlled setting using healthy subjects involving different physical activities. Ten different activities were assessed showing a tenfold cross valida...
Source: IEEE Transactions on Biomedical Engineering - October 17, 2014 Category: Biomedical Engineering Source Type: research

Design of a Breath Analysis System for Diabetes Screening and Blood Glucose Level Prediction
It has been reported that concentrations of several biomarkers in diabetics’ breath show significant difference from those in healthy people's breath. Concentrations of some biomarkers are also correlated with the blood glucose levels (BGLs) of diabetics. Therefore, it is possible to screen for diabetes and predict BGLs by analyzing one's breath. In this paper, we describe the design of a novel breath analysis system for this purpose. The system uses carefully selected chemical sensors to detect biomarkers in breath. Common interferential factors, including humidity and the ratio of alveolar air in bre...
Source: IEEE Transactions on Biomedical Engineering - October 17, 2014 Category: Biomedical Engineering Source Type: research