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This page shows you the most recent publications within this specialty of the MedWorm directory.

Development and performance of a new prosthesis system using ultrasonic sensor for wrist movements: a preliminary study
Conclusion: The new development of using sensor and actuator in generating the wrist movements will be interesting for used list in medicine, robotics technology, rehabilitations, prosthetics and orthotics. (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - April 23, 2014 Category: Biomedical Engineering Authors: Nasrul Abd RazakNoor Abu OsmanHossein GholizadehSadeeq Ali Source Type: research

Integrated Circuits and Electrode Interfaces for Noninvasive Physiological Monitoring
This paper presents an overview of the fundamentals and state of the-art in noninvasive physiological monitoring instrumentation with a focus on electrode and optrode interfaces to the body, and micropower-integrated circuit design for unobtrusive wearable applications. Since the electrode/optrode–body interface is a performance limiting factor in noninvasive monitoring systems, practical interface configurations are offered for biopotential acquisition, electrode–tissue impedance measurement, and optical biosignal sensing. A systematic approach to instrumentation amplifier (IA) design using CMOS transistors ...
Source: IEEE Transactions on Biomedical Engineering - April 22, 2014 Category: Biomedical Engineering Source Type: research

Automatic method of analysis of OCT images in the assessment of the tooth enamel surface after orthodontic treatment with fixed braces
Conclusions: This paper presents an automatic quantitative method for the assessment of tooth enamel thickness. This method has proven to be an effective diagnostic tool that allows evaluation of the surface and cross section of tooth enamel after orthodontic treatment with fixed thin-arched braces and proper selection of the methodology and course of treatment. (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - April 22, 2014 Category: Biomedical Engineering Authors: Robert KoprowskiMonika MachoyKrzysztof WozniakZygmunt Wróbel Source Type: research

Automatic method for the dermatological diagnosis of selected hand skin features in hyperspectral imaging
Conclusions: The obtained results confirmed the usefulness of the proposed new method of image analysis and processing in dermatology of the hand as it enables reproducible, quantitative assessment of any fragment of this body part. Each image in a sequence was analysed in this way in no more than 100 ms using Intel Core i5 CPU M460 @ 2.5GHz 4GB RAM. (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - April 22, 2014 Category: Biomedical Engineering Authors: Robert KoprowskiS¿awomir Wilczy¿skiZygmunt WróbelS¿awomir KasperczykBarbara B¿o¿ska-Fajfrowska Source Type: research

Joint Space Decomposition-and-Synthesis Approach and Achievable DoF Regions for -User MIMO Interference Channels
The paper proposes a new approach of joint space decomposition-and-synthesis (JSDS) for deriving achievable degree-of-freedom (DoF) region by interference alignment without symbol extension for $K$-user MIMO interference channel. Solving the interference alignment problem is to find the precoders that align desired signal and interference with disjoint subspaces at receivers. A related property of these precoders is that the solution range for each one of them is a union of linear spaces, termed transmit spaces. Based on this property, the JSDS approach is developed to derive transmit spaces that fulfill alignment conditio...
Source: IEEE Transactions on Signal Processing - April 18, 2014 Category: Biomedical Engineering Source Type: research

Regularization: Convergence of Iterative Half Thresholding Algorithm
In recent studies on sparse modeling, the nonconvex regularization approaches (particularly, $L_{q}$ regularization with $qin(0,1)$ ) have been demonstrated to possess capability of gaining much benefit in sparsity-inducing and efficiency. As compared with the convex regularization approaches (say, $L_{1}$ regularization), however, the convergence issue of the corresponding algorithms are more difficult to tackle. In this paper, we deal with this difficult issue for a specific but typical nonconvex regularization scheme, the $L_{1/2}$ regularization, which has been successfully used to many applications. More specifically,...
Source: IEEE Transactions on Signal Processing - April 18, 2014 Category: Biomedical Engineering Source Type: research

IEEE Transactions on Biomedical Engineering Associate Editors
(Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - April 18, 2014 Category: Biomedical Engineering Source Type: research

36th Annaual International Conference of the IEEE Engineering in Medicine and Biology Society
(Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - April 18, 2014 Category: Biomedical Engineering Source Type: research

IEEE Transactions on Biomedical Engineering information for authors
(Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - April 18, 2014 Category: Biomedical Engineering Source Type: research

Advancing Our Understanding of the Glucose System via Modeling: A Perspective
The glucose story begins with Claude Bernard's discovery of glycogen and milieu interieur, continued with Banting's and Best's discovery of insulin and with Rudolf Schoenheimer's paradigm of dynamic body constituents. Tracers and compartmental models allowed moving to the first quantitative pictures of the system and stimulated important developments in terms of modeling methodology. Three classes of multiscale models, models to measure, models to simulate, and models to control the glucose system, are reviewed in their historical development with an eye to the future. (Source: IEEE Transactions...
Source: IEEE Transactions on Biomedical Engineering - April 18, 2014 Category: Biomedical Engineering Source Type: research

Dissecting Heart Failure Through the Multiscale Approach of Systems Medicine
Heart failure (HF) is a complex syndrome which can be the exit of different etiologies which lead to a common clinical picture. Treatment outcome is modest and new insights into pathophysiology are needed to improve effectively diagnosis, prognosis, and therapy. As a complex disease, it can really benefit from the new approach provided by molecular medicine where information about the cell program can deeply change the patient management. The comprehension of molecular mechanisms relies on new technologies which are able to provide data at the different levels of the cell workflow. A proper processing of these data is as e...
Source: IEEE Transactions on Biomedical Engineering - April 18, 2014 Category: Biomedical Engineering Source Type: research

Unobtrusive Sensing and Wearable Devices for Health Informatics
The aging population, prevalence of chronic diseases, and outbreaks of infectious diseases are some of the major challenges of our present-day society. To address these unmet healthcare needs, especially for the early prediction and treatment of major diseases, health informatics, which deals with the acquisition, transmission, processing, storage, retrieval, and use of health information, has emerged as an active area of interdisciplinary research. In particular, acquisition of health-related information by unobtrusive sensing and wearable technologies is considered as a cornerstone in health informatics. Sensors can be w...
Source: IEEE Transactions on Biomedical Engineering - April 18, 2014 Category: Biomedical Engineering Source Type: research

A Review of Multitaper Spectral Analysis
Nonparametric spectral estimation is a widely used technique in many applications ranging from radar and seismic data analysis to electroencephalography (EEG) and speech processing. Among the techniques that are used to estimate the spectral representation of a system based on finite observations, multitaper spectral estimation has many important optimality properties, but is not as widely used as it possibly could be. We give a brief overview of the standard nonparametric spectral estimation theory and the multitaper spectral estimation, and give two examples from EEG analyses of anesthesia and sleep. (Source: IEEE Transa...
Source: IEEE Transactions on Biomedical Engineering - April 18, 2014 Category: Biomedical Engineering Source Type: research

From Passive Tool Holders to Microsurgeons: Safer, Smaller, Smarter Surgical Robots
Within only a few decades from its initial introduction, the field of surgical robotics has evolved into a dynamic and rapidly growing research area with increasing clinical uptake worldwide. Initially introduced for stereotaxic neurosurgery, surgical robots are now involved in an increasing number of procedures, demonstrating their practical clinical potential while propelling further advances in surgical innovations. Emerging platforms are also able to perform complex interventions through only a single-entry incision, and navigate through natural anatomical pathways in a tethered or wireless fashion. New devices facilit...
Source: IEEE Transactions on Biomedical Engineering - April 18, 2014 Category: Biomedical Engineering Source Type: research

Toward Integrated Molecular Diagnostic System ($i$ MDx): Principles and Applications
Integrated molecular diagnostic systems ($i$MDx), which are automated, sensitive, specific, user-friendly, robust, rapid, easy-to-use, and portable, can revolutionize future medicine. This review will first focus on the components of sample extraction, preservation, and filtration necessary for all point-of-care devices to include for practical use. Subsequently, we will look for low-powered and precise methods for both sample amplification and signal transduction, going in-depth to the details behind their principles. The final field of total device integration and its application to the clinical field will also be addres...
Source: IEEE Transactions on Biomedical Engineering - April 18, 2014 Category: Biomedical Engineering Source Type: research

Hydrogels as Carriers for Stem Cell Transplantation
Stem cells are a promising source for cell replacement therapy for several degenerative conditions. However, a number of limitations such as low cell survival, uncontrolled and/or low differentiation, induction of host immune response, and the risk of teratoma formation remain as challenges. In this review, we explore the utility of hydrogels as carriers for stem cell delivery and their potential to overcome some of the current limitations in stem cell therapy. We focus on in situ gelling hydrogels, and also discuss other strategies to modulate the immune response to promote controlled stem cell differentiation. Immunomodu...
Source: IEEE Transactions on Biomedical Engineering - April 18, 2014 Category: Biomedical Engineering Source Type: research

Strategies for Whole Lung Tissue Engineering
Recent work has demonstrated the feasibility of using decellularized lung extracellular matrix scaffolds to support the engineering of functional lung tissue in vitro. Rendered acellular through the use of detergents and other reagents, the scaffolds are mounted in organ-specific bioreactors where cells in the scaffold are provided with nutrients and appropriate mechanical stimuli such as ventilation and perfusion. Though initial studies are encouraging, a great deal remains to be done to advance the field and transition from rodent lungs to whole human tissue engineered lungs. To do so, a variety of hurdles must be overco...
Source: IEEE Transactions on Biomedical Engineering - April 18, 2014 Category: Biomedical Engineering Source Type: research

Recent Advances in Thermal Treatment Techniques and Thermally Induced Immune Responses Against Cancer
In the past decades, techniques for tumor diagnosis and treatment have been significantly advanced. However, the five-year survival rate of cancer patients remains low. New modalities are highly desirable based on technology innovation and translational medicine. In this paper, recent outcomes of thermal ablation techniques are reviewed, including thermal energy delivery methods, thermally induced immune responses in depth. It is suggested that the synergy of local thermal ablation and thermally induced whole body immune response could be a promising direction for effective cancer therapy in the near future, especially for...
Source: IEEE Transactions on Biomedical Engineering - April 18, 2014 Category: Biomedical Engineering Source Type: research

A Shocking Past: A Walk Through Generations of Defibrillation Development
Defibrillation is one of the most successful and widely recognized applications of electrotherapy. Yet the historical road to its first successful application in a patient and the innovative adaptation to an implantable device is marred with unexpected turns, political and personal setbacks, and public and scientific condemnation at each new idea. Driven by dedicated scientists and ever-advancing creative applications of new technologies, from electrocardiography to high density mapping and computational simulations, the field of defibrillation persevered and continued to evolve to the life-saving tool it is today. In addi...
Source: IEEE Transactions on Biomedical Engineering - April 18, 2014 Category: Biomedical Engineering Source Type: research

The Past, Present, and Future of Real-Time Control in Cellular Electrophysiology
For over 60 years, real-time control has been an important technique in the study of excitable cells. Two such control-based technologies are reviewed here. First, voltage-clamp methods revolutionized the study of excitable cells. In this family of techniques, membrane potential is controlled, allowing one to parameterize a powerful class of models that describe the voltage-current relationship of cell membranes simply, flexibly, and accurately. Second, dynamic-clamp methods allow the addition of new, “virtual” membrane mechanisms to living cells. Dynamic clamp allows researchers unprecedented ways of ...
Source: IEEE Transactions on Biomedical Engineering - April 18, 2014 Category: Biomedical Engineering Source Type: research

A Brief History of Tissue Models For Cardiac Electrophysiology
The last four decades have produced a number of significant advances in the developments of computer models to simulate and investigate the electrical activity of cardiac tissue. The tissue descriptions that underlie these simulations have been built from a combination of clever insight and careful comparison with measured data at multiple scales. Tissue models have not only led to greater insights into the mechanisms of life-threatening arrhythmias but have been used to engineer new therapies to treat the consequences of cardiac disease. This paper is a look back at the early years in the cardiac modeling and the challeng...
Source: IEEE Transactions on Biomedical Engineering - April 18, 2014 Category: Biomedical Engineering Source Type: research

Visual and Auditory Brain–Computer Interfaces
Over the past several decades, electroencephalogram (EEG)-based brain–computer interfaces (BCIs) have attracted attention from researchers in the field of neuroscience, neural engineering, and clinical rehabilitation. While the performance of BCI systems has improved, they do not yet support widespread usage. Recently, visual and auditory BCI systems have become popular because of their high communication speeds, little user training, and low user variation. However, building robust and practical BCI systems from physiological and technical knowledge of neural modulation of visual and auditory brain responses remain...
Source: IEEE Transactions on Biomedical Engineering - April 18, 2014 Category: Biomedical Engineering Source Type: research

Brain–Computer Interfaces Using Sensorimotor Rhythms: Current State and Future Perspectives
Many studies over the past two decades have shown that people can use brain signals to convey their intent to a computer using brain–computer interfaces (BCIs). BCI systems extract specific features of brain activity and translate them into control signals that drive an output. Recently, a category of BCIs that are built on the rhythmic activity recorded over the sensorimotor cortex, i.e., the sensorimotor rhythm (SMR), has attracted considerable attention among the BCIs that use noninvasive neural recordings, e.g., electroencephalography (EEG), and have demonstrated the capability of multidimensional prosthesis con...
Source: IEEE Transactions on Biomedical Engineering - April 18, 2014 Category: Biomedical Engineering Source Type: research

Retinal Prosthesis
Retinal prosthesis has been translated from the laboratory to the clinic over the past two decades. Currently, two devices have regulatory approval for the treatment of retinitis pigmentosa. These devices provide partial sight restoration and patients use this improved vision in their everyday lives. Improved mobility and object detection are some of the more notable findings from the clinical trials. However, significant vision restoration will require both better technology and improved understanding of the interaction between electrical stimulation and the retina. This paper reviews the recent clinical trials and highli...
Source: IEEE Transactions on Biomedical Engineering - April 18, 2014 Category: Biomedical Engineering Source Type: research

Electrical Tissue Property Imaging at Low Frequency Using MREIT
The tomographic imaging of tissue’s electrical properties (e.g., conductivity and permittivity) has been greatly improved by recent developments in magnetic resonance (MR) imaging techniques, which include MR electrical impedance tomography (MREIT) and electrical property tomography. When the biological material is subjected to an external electric field, local changes in its electrical properties become sources of magnetic field perturbations, which are detectable by the MR signals. Controlling the external excitation and measuring the responses using an MRI scanner, we can formulate the imaging problem as an inver...
Source: IEEE Transactions on Biomedical Engineering - April 18, 2014 Category: Biomedical Engineering Source Type: research

Breast Cancer Histopathology Image Analysis: A Review
This paper presents an overview of methods that have been proposed for the analysis of breast cancer histopathology images. This research area has become particularly relevant with the advent of whole slide imaging (WSI) scanners, which can perform cost-effective and high-throughput histopathology slide digitization, and which aim at replacing the optical microscope as the primary tool used by pathologist. Breast cancer is the most prevalent form of cancers among women, and image analysis methods that target this disease have a huge potential to reduce the workload in a typical pathology lab and to improve the quality of t...
Source: IEEE Transactions on Biomedical Engineering - April 18, 2014 Category: Biomedical Engineering Source Type: research