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This page shows you the most recent publications within this specialty of the MedWorm directory.

Multifractal analysis of tumour microscopic images in the prediction of breast cancer chemotherapy response.
Abstract Due to the individual heterogeneity, highly accurate predictors of chemotherapy response in invasive breast cancer are needed for effective chemotherapeutic management. However, predictive molecular determinants for conventional chemotherapy are only emerging and still incorporate a high degree of predictive variability. Based on such pressing need for predictive performance improvement, we explored the value of pre-therapy tumour histology image analysis to predict chemotherapy response. Fractal analysis was applied to hematoxylin/eosin stained archival tissue of diagnostic biopsies derived from 106 patie...
Source: Biomedical Microdevices - August 26, 2015 Category: Biomedical Engineering Authors: Vasiljevic J, Pribic J, Kanjer K, Jonakowski W, Sopta J, Nikolic-Vukosavljevic D, Radulovic M Tags: Biomed Microdevices Source Type: research

Recording axonal conduction to evaluate the integration of pluripotent cell-derived neurons into a neuronal network.
In this study, we applied an axonal conduction-based analysis to a co-culture study of primary and differentiated neurons. Mouse cortical neurons and neuronal cells differentiated from P19 embryonal carcinoma cells, a model for early neural differentiation of pluripotent stem cells, were co-cultured in a microfabricated device. The somata of these cells were separated by the co-culture device, but their axons were able to elongate through microtunnels and then form synaptic contacts. Propagating action potentials were recorded from these axons by microelectrodes embedded at the bottom of the microtunnels and sorted into cl...
Source: Biomedical Microdevices - August 26, 2015 Category: Biomedical Engineering Authors: Shimba K, Sakai K, Takayama Y, Kotani K, Jimbo Y Tags: Biomed Microdevices Source Type: research

A 3-dimensional fibre scaffold as an investigative tool for studying the morphogenesis of isolated plant pells
A new technique borrows from biomedical engineering to study plant cells in culture conditions that mimic tissue scaffolds, allowing for a more physiologically relevant way to explore cell-environment interactions. (Source: BMC Plant Biology)
Source: BMC Plant Biology - August 26, 2015 Category: Biology Authors: CJ LuoRaymond WightmanElliot MeyerowitzStoyan K. Smoukov Source Type: research

On Maximum-Likelihood Blind Synchronization Over WSSUS Channels for OFDM Systems
Various blind synchronization methods built on the maximum likelihood (ML) principle have been proposed, where the addressed scenarios include additive white Gaussian noise (AWGN), single-path fading, and multipath fading channels. We consider ML blind synchronization over wide-sense stationary uncorrelated scattering (WSSUS) channels. Different from existing studies, we exploit a more complete signal correlation function and find the carrier frequency offset estimate to be the solution of a quartic equation, rather than the phase angle of a complex number. As the truly ML synchronizer (dubbed MLE) is very complicated, we ...
Source: IEEE Transactions on Signal Processing - August 25, 2015 Category: Biomedical Engineering Source Type: research

RSSI-Based Multi-Target Tracking by Cooperative Agents Using Fusion of Cross-Target Information
We present computer simulations that compare the new method with conventional approaches in settings with two and 20 targets, respectively. They demonstrate the improvements of the proposed method in tracking a relatively large number of targets. (Source: IEEE Transactions on Signal Processing)
Source: IEEE Transactions on Signal Processing - August 25, 2015 Category: Biomedical Engineering Source Type: research

Robust Decentralized Detection and Social Learning in Tandem Networks
We study a tandem of agents who make decisions about an underlying binary hypothesis, where the distribution of the agent observations under each hypothesis comes from an uncertainty class defined by a 2-alternating capacity. We investigate both decentralized detection rules, where agents collaborate to minimize the error probability of the final agent, and social learning rules, where each agent minimizes its own local minimax error probability. We then extend our results to the infinite tandem network, and derive necessary and sufficient conditions on the uncertainty classes for the minimax error probability to converge ...
Source: IEEE Transactions on Signal Processing - August 25, 2015 Category: Biomedical Engineering Source Type: research

The concept of frozen elastic energy as a consequence of changes in microstructure morphology.
PMID: 26304474 [PubMed - as supplied by publisher] (Source: Computer Methods in Biomechanics and Biomedical Engineering)
Source: Computer Methods in Biomechanics and Biomedical Engineering - August 25, 2015 Category: Biomedical Engineering Authors: Krasny W, Morin C, Avril S, Magoariec H, Hellmich C Tags: Comput Methods Biomech Biomed Engin Source Type: research

Dealing with modularity of multibody models.
PMID: 26304471 [PubMed - as supplied by publisher] (Source: Computer Methods in Biomechanics and Biomedical Engineering)
Source: Computer Methods in Biomechanics and Biomedical Engineering - August 25, 2015 Category: Biomedical Engineering Authors: Muller A, Pontonnier C, Germain C, Dumont G Tags: Comput Methods Biomech Biomed Engin Source Type: research

New equations to calculate 3D joint centres in the lower extremities
Movement analyses of the lower extremities in three dimensions are typically based on motion capture of markers placed on anatomical landmarks according to a marker setup by which the anatomical hip, knee and ankle joint centres are predicted by regression equations. However, the usage of markers has several kinematic and kinetic limitations due to soft tissue artefacts (STA) and variations in the marker placement [1-7]. Besides STA and variability of the marker placement, errors associated with the regression equations used to calculate the joint centre locations are also considerable [8–10]. (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - August 25, 2015 Category: Biomedical Engineering Authors: Martin Sandau, Rikke V. Heimbürger, Chiara Villa, Karl E. Jensen, Thomas B. Moeslund, Henrik Aanæs, Tine Alkjær, Erik B. Simonsen Source Type: research

Response of single cell with acute angle exposed to an external electric field
Evaluation of responses of single cell organisms exposed to external electromagnetic fields in recently decade has increased significantly [4,5,10–13,18,23–25,29–31]. The information acquired from this response under electric and magnetic fields can play an important role in biology, biotechnology and medicine [3,6–8,14–17]. An external electric field can change the membrane voltage and impair endogenous membrane voltage [9,29,47]. In fact this sensitivity to applied external electric field leads to a significant increase of transmembrane voltage [9,18]. (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - August 23, 2015 Category: Biomedical Engineering Authors: Saber Sarbazvatan, Dariush Sardari, Nahid Taheri, Kamran Sepanloo Source Type: research

A review of the functionalities of smart walkers
Stability and balance in ambulation are fundamental to independent activity and quality of life. Individuals who do not have such stability and balance require the help of assistive devices that may improve their condition [1,2]. (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - August 23, 2015 Category: Biomedical Engineering Authors: Maria Martins, Cristina Santos, Anselmo Frizera, Ramón Ceres Source Type: research

Effect of power-assisted hand-rim wheelchair propulsion on shoulder load in experienced wheelchair users: A pilot study with an instrumented wheelchair
Incidences of shoulder overuse injuries among hand-rim wheelchair users are high with figures varying between 30 and 73% in the chronic spinal cord injury population [1–3]. It is suggested that part of the risk factors for overuse originate in wheelchair propulsion itself. Characteristics of hand-rim propulsion related to shoulder overuse injuries are the intensity of mechanical loading of the shoulder during the push phase, the highly repetitive nature of propulsion motions and force generation in extremes of shoulder motion [2,4–8]. (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - August 23, 2015 Category: Biomedical Engineering Authors: Marieke G.M. Kloosterman, Jaap H. Buurke, Wiebe de Vries, Lucas H.V. Van der Woude, Johan S. Rietman Source Type: research

Validation of a method for combining biplanar radiography and magnetic resonance imaging to estimate knee cartilage contact
Estimation of in vivo knee joint contact is technically challenging, particularly during functionally relevant loading. Understanding the location and area of contact between the articulating joint surfaces can provide essential and clinically relevant insight into joint function of normal, injured, and surgically operative or rehabilitated knees. Articular cartilage contact has been assessed in the knee [1–9]. Methods for analyzing knee contact have typically utilized magnetic resonance imaging (MRI) to directly assess opposing cartilage and meniscal tissues in both unloaded supine conditions and simulated loading durin...
Source: Medical Engineering and Physics - August 23, 2015 Category: Biomedical Engineering Authors: Eric Thorhauer, Scott Tashman Source Type: research

Dielectrophoretic characterization of cells in a stationary nanoliter droplet array with generated chemical gradients.
Abstract A novel design of reusable microfluidic platform that generates a stationary nanoliter droplet array (SNDA) for cell incubation and analysis, equipped with a complementary array of individually addressable electrodes for each microwell is studied. Various solute concentration gradients were generated between the wells where dielectrophoresis (DEP) was used to characterize the effect of the gradients on the cell's response. The feasibility of generating concentration gradients and observation of DEP responses was demonstrated using a gradient of salts in combination with microparticles and viable cells. L12...
Source: Biomedical Microdevices - August 22, 2015 Category: Biomedical Engineering Authors: Ben-Arye T, Park S, Shemesh J, Peer D, Levenberg S, Yossifon G Tags: Biomed Microdevices Source Type: research

Early prognosis of metastasis risk in inflammatory breast cancer by texture analysis of tumour microscopic images.
This study indicates for the first time the potential use of primary breast tumour histology texture as a highly accurate, simple and cost-effective prognostic indicator of metastasis risk in IBC. Clinical relevance of the obtained results rests on the role of prognosis in decisions on induction chemotherapy and the resulting impact on quality of life and survival. PMID: 26286863 [PubMed - in process] (Source: Biomedical Microdevices)
Source: Biomedical Microdevices - August 22, 2015 Category: Biomedical Engineering Authors: Kolarevic D, Tomasevic Z, Dzodic R, Kanjer K, Vukosavljevic DN, Radulovic M Tags: Biomed Microdevices Source Type: research

Biomimetic repeat protein derived from Xenopus tropicalis for fibrous scaffold fabrication
This article is protected by copyright. All rights reserved. (Source: Biopolymers)
Source: Biopolymers - August 22, 2015 Category: Biochemistry Authors: Yunkyeoung Kwon, Yun Jung Yang, Dooyup Jung, Byeong Hee Hwang, Hyung Joon Cha Tags: Rapid Communication Source Type: research

Comparative whole genome transcriptome and metabolome analyses of five Klebsiella pneumonia strains.
Abstract The integration of transcriptomics and metabolomics can provide precise information on gene-to-metabolite networks for identifying the function of novel genes. The goal of this study was to identify novel gene functions involved in 2,3-butanediol (2,3-BDO) biosynthesis by a comprehensive analysis of the transcriptome and metabolome of five mutated Klebsiella pneumonia strains (∆wabG = SGSB100, ∆wabG∆budA = SGSB106, ∆wabG∆budB = SGSB107, ∆wabG∆budC = SGSB108, ∆wabG∆budABC = SGSB109). First, the transcriptomes of all five mutants were analyzed and the genes exhibiting reproducible...
Source: Bioprocess and Biosystems Engineering - August 22, 2015 Category: Biomedical Engineering Authors: Lee S, Kim B, Yang J, Jeong D, Park S, Shin SH, Kook JH, Yang KS, Lee J Tags: Bioprocess Biosyst Eng Source Type: research

Patient-Specific Biomechanical Modeling for Guidance During Minimally-Invasive Hepatic Surgery.
Abstract During the minimally-invasive liver surgery, only the partial surface view of the liver is usually provided to the surgeon via the laparoscopic camera. Therefore, it is necessary to estimate the actual position of the internal structures such as tumors and vessels from the pre-operative images. Nevertheless, such task can be highly challenging since during the intervention, the abdominal organs undergo important deformations due to the pneumoperitoneum, respiratory and cardiac motion and the interaction with the surgical tools. Therefore, a reliable automatic system for intra-operative guidance requires fa...
Source: Annals of Biomedical Engineering - August 22, 2015 Category: Biomedical Engineering Authors: Plantefève R, Peterlik I, Haouchine N, Cotin S Tags: Ann Biomed Eng Source Type: research

On the Compressibility of Arterial Tissue.
Abstract Arterial tissue is commonly assumed to be incompressible. While this assumption is convenient for both experimentalists and theorists, the compressibility of arterial tissue has not been rigorously investigated. In the current study we present an experimental-computational methodology to determine the compressibility of aortic tissue and we demonstrate that specimens excised from an ovine descending aorta are significantly compressible. Specimens are stretched in the radial direction in order to fully characterise the mechanical behaviour of the tissue ground matrix. Additionally biaxial testing is perform...
Source: Annals of Biomedical Engineering - August 22, 2015 Category: Biomedical Engineering Authors: Nolan DR, McGarry JP Tags: Ann Biomed Eng Source Type: research

Optimized Configurable Architectures for Scalable Soft-Input Soft-Output MIMO Detectors With 256-QAM
This paper presents an optimized low-complexity and high-throughput MIMO signal detector core for detecting spatially multiplexed data streams. The core architecture supports various layer configurations up to 4, while achieving near-optimal performance, and configurable modulation constellations up to 256-QAM on each layer. The core is capable of operating as a soft-input soft-output log-likelihood ratio (LLR) MIMO detector which can be used in the context of iterative detection and decoding. High area-efficiency is achieved via algorithmic and architectural optimizations performed at two levels. First, distance computati...
Source: IEEE Transactions on Signal Processing - August 21, 2015 Category: Biomedical Engineering Source Type: research

Semi-Blind Receivers for Non-Regenerative Cooperative MIMO Communications Based on Nested PARAFAC Modeling
In cooperative communication systems, multiple-input multiple-output (MIMO) amplify-and-forward (AF) relaying is a promising solution for upcoming wireless standards due to its intrinsic benefits in terms of extended coverage and increased spatial diversity. However, the deployment of MIMO AF relays faces some key challenges such as the need of channel state information (CSI) for the partial channels associated with the different communication links, which is required by some transmit optimization techniques. In this paper, we consider a one-way two-hop MIMO AF cooperative scheme employing space-time (ST) codings at the tr...
Source: IEEE Transactions on Signal Processing - August 21, 2015 Category: Biomedical Engineering Source Type: research

Semi-Widely Simulation and Estimation of Continuous-Time $BBC^{eta}$ -Proper Quaternion Random Signals
The repercussions of quaternion $BBC^{eta}$-properness on the continuous-time simulation and estimation problems are studied. As a first step, a semi-widely linear quaternion Karhunen–Loève expansion is derived. Then this series representation is used in both problems to give the solutions. The simulation technique proposed is useful for transformations of nonstationary Gaussian quaternion signals. The estimation problem is also analyzed in a continuous-discrete setting and by considering two different formulations: the Cambanis formulation and the signal plus noise model. Initially, the estimators are develo...
Source: IEEE Transactions on Signal Processing - August 21, 2015 Category: Biomedical Engineering Source Type: research

Analysis and Design of Multiple-Antenna Cognitive Radios With Multiple Primary User Signals
We consider multiple-antenna signal detection of primary user transmission signals by a secondary user receiver in cognitive radio networks. The optimal detector is analyzed for the scenario where the number of primary user signals is no less than the number of receive antennas at the secondary user. We first derive exact expressions for the moments of the generalized likelihood ratio test (GLRT) statistic, yielding approximations for the false alarm and detection probabilities. We then show that the normalized GLRT statistic converges in distribution to a Gaussian random variable when the number of antennas and observatio...
Source: IEEE Transactions on Signal Processing - August 21, 2015 Category: Biomedical Engineering Source Type: research

Nested Sparse Approximation: Structured Estimation of V2V Channels Using Geometry-Based Stochastic Channel Model
Future intelligent transportation systems promise increased safety and energy efficiency. Realization of such systems will require vehicle-to-vehicle (V2V) communication technology. High fidelity V2V communication is, in turn, dependent on accurate V2V channel estimation. V2V channels have characteristics differing from classical cellular communication channels. Herein, geometry-based stochastic modeling is employed to develop a characterization of V2V channel channels. The resultant model exhibits significant structure; specifically, the V2V channel is characterized by three distinct regions within the delay-Doppler plane...
Source: IEEE Transactions on Signal Processing - August 21, 2015 Category: Biomedical Engineering Source Type: research

Ziv–Zakai Bound for Joint Parameter Estimation in MIMO Radar Systems
Local bounds, such as the Cramer–Rao bound (CRB), provide inaccurate predictions under low signal-to-noise ratio (SNR) conditions. Global bounds are capable of providing more accurate predictions of the performance of estimators over the full range of SNR. In this paper, we derive the Ziv–Zakai bound (ZZB) for joint location and velocity estimation of a target illuminated by a non-coherent multiple-input multiple-output (MIMO) radar employing orthogonal waveforms and widely spaced antennas. The setup captures the multistatic nature of the target gains, where each pair of transmit-receive elements experience i...
Source: IEEE Transactions on Signal Processing - August 21, 2015 Category: Biomedical Engineering Source Type: research

Fixed-Point Analysis and Parameter Optimization of the Radix- Pipelined FFT Processor
The radix-$2^{k}$ algorithm plays a crucial role in the pipelined implementation of fast Fourier transform (FFT). This paper presents a fixed-point analysis and hardware evaluation of radix- $2^{k}$ FFT under the framework of the single-path delay feedback (SDF) and multi-path delay commutator (MDC) pipelined structure. The investigation is carried out with variable operating word-lengths to ensure the generality. Furthermore, the main streams to fulfill FFT coefficients weighting, namely, the approach using complex multipliers and the one adopting memoryless CORDIC units, are both considered in the analysis. Based on thes...
Source: IEEE Transactions on Signal Processing - August 21, 2015 Category: Biomedical Engineering Source Type: research

Estimation of Toeplitz Covariance Matrices in Large Dimensional Regime With Application to Source Detection
In this paper, we derive concentration inequalities for the spectral norm of two classical sample estimators of large dimensional Toeplitz covariance matrices, demonstrating in particular their asymptotic almost sure consistence. The consistency is then extended to the case where the aggregated matrix of time samples is corrupted by a rank one (or more generally, low rank) matrix. As an application of the latter, the problem of source detection in the context of large dimensional sensor networks within a temporally correlated noise environment is studied. As opposed to standard procedures, this application is performed onl...
Source: IEEE Transactions on Signal Processing - August 21, 2015 Category: Biomedical Engineering Source Type: research

Compressive Sensing With Prior Support Quality Information and Application to Massive MIMO Channel Estimation With Temporal Correlation
In this paper, we consider the problem of compressive sensing (CS) recovery with a prior support and the prior support quality information available. Different from classical works which exploit prior support blindly, we shall propose novel CS recovery algorithms to exploit the prior support adaptively based on the quality information. We analyze the distortion bound of the recovered signal from the proposed algorithm and we show that a better quality prior support can lead to better CS recovery performance. We also show that the proposed algorithm would converge in ${cal O}(log{rm SNR})$ steps. To tolerate possible model ...
Source: IEEE Transactions on Signal Processing - August 21, 2015 Category: Biomedical Engineering Source Type: research

BHI-2016 International Conference on Biomedical and Health Informatics
(Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - August 21, 2015 Category: Biomedical Engineering Source Type: research

IEEE Transactions on Biomedical Engineering information for authors
(Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - August 21, 2015 Category: Biomedical Engineering Source Type: research

IEEE Transactions on Biomedical Engineering Handling Editors
(Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - August 21, 2015 Category: Biomedical Engineering Source Type: research

Adaptive Noise Suppression of Pediatric Lung Auscultations With Real Applications to Noisy Clinical Settings in Developing Countries
Goal: Chest auscultation constitutes a portable low-cost tool widely used for respiratory disease detection. Though it offers a powerful means of pulmonary examination, it remains riddled with a number of issues that limit its diagnostic capability. Particularly, patient agitation (especially in children), background chatter, and other environmental noises often contaminate the auscultation, hence affecting the clarity of the lung sound itself. This paper proposes an automated multiband denoising scheme for improving the quality of auscultation signals against heavy background contaminations. Methods: The algorithm works o...
Source: IEEE Transactions on Biomedical Engineering - August 21, 2015 Category: Biomedical Engineering Source Type: research

A Smart Capsule With GI-Tract-Location-Specific Payload Release
In this paper, we present a smart capsule for location-specific drug release in the gastrointestinal tract. Once activated through a magnetic proximity fuse, the capsule opens up and releases its powdered payload in a location specified by an implanted miniature magnetic marker or an externally worn larger magnet. The capsule (9 mm × 26 mm) comprises of two compartments: one contains a charged capacitor and a reed switch, while the second one houses the drug reservoir capped by a taut nylon thread intertwined with a nichrome wire. The nichrome wire is connected to the capacitor through the reed switch....
Source: IEEE Transactions on Biomedical Engineering - August 21, 2015 Category: Biomedical Engineering Source Type: research

Global and Local Panoramic Views for Gastroscopy: An Assisted Method of Gastroscopic Lesion Surveillance
Gastroscopy plays an important role in the diagnosis of gastric disease. In this paper, we develop an image panoramic system to assist endoscopists in improving lesion surveillance and reducing many of the tedious operations associated with gastroscopy. The constructed panoramic view has two categories: 1) the local view broadens the endoscopist's field of view in real time. Combining with the original gastroscopic video, this mosaicking view enables the endoscopist to diagnose the lesion comprehensively; 2) the global view constructs a large-area panoramic scene of the internal gastric surface, which can be used fo...
Source: IEEE Transactions on Biomedical Engineering - August 21, 2015 Category: Biomedical Engineering Source Type: research

Monte Carlo Investigation of Optical Coherence Tomography Retinal Oximetry
Optical coherence tomography (OCT) oximetry explores the possibility to measure retinal hemoglobin oxygen saturation level (sO2). We investigated the accuracy of OCT retinal oximetry using Monte Carlo simulation in a commonly used four-layer retinal model. After we determined the appropriate number of simulated photon packets, we studied the effects of blood vessel diameter, signal sampling position, physiological sO2 level, and the blood packing factor on the accuracy of sO2 estimation in OCT retinal oximetry. The simulation results showed that a packing factor between 0.2 and 0.4 yields a reasonably accurate estimation o...
Source: IEEE Transactions on Biomedical Engineering - August 21, 2015 Category: Biomedical Engineering Source Type: research

Design and Evaluation of a Novel Fixation Mechanism for a Transcatheter Pacemaker
Conclusion: The nitinol tine fixation design enabled the implant of a self-contained pacemaker within the right ventricle and was effective in meeting the design requirements. Significance: This fixation technology provides a novel solution to enable the attachment of a transcatheter pacemaker directly within the heart. (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - August 21, 2015 Category: Biomedical Engineering Source Type: research

Local Gradients in Electrotonic Loading Modulate the Local Effective Refractory Period: Implications for Arrhythmogenesis in the Infarct Border Zone
This study uses in-silico experiments to examine the structural modulation of effective refractory period on ectopic beat capture. Informed by 3-D reconstructions of myocyte organization in the infarct border zone, a region of rapid tissue expansion is abstracted to an idealized representation. A novel metric is introduced that defines the local electrotonic loading as a function of passive tissue properties and boundary conditions. The effective refractory period correlates closely with local electrotonic loading, while the action potential duration, conduction, and upstroke velocity reduce in regions of increasing electr...
Source: IEEE Transactions on Biomedical Engineering - August 21, 2015 Category: Biomedical Engineering Source Type: research