Biomedical Engineering Biomedical Engineering RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 13.

Front Cover
(Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - December 22, 2015 Category: Biomedical Engineering Source Type: research

IEEE Transactions on Biomedical Engineering publication information
(Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - December 22, 2015 Category: Biomedical Engineering Source Type: research

Track E. Cellular, Tissue and Bioengineering.
Authors: Becker A, Zernetsch H, Mueller M, Glasmacher B PMID: 26360468 [PubMed - in process] (Source: Biomedizinische Technik/Biomedical Engineering)
Source: Biomedizinische Technik/Biomedical Engineering - December 22, 2015 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Track A. Biomaterials and Biocompatibility 1.
Authors: Zaatreh S, Haffner D, Pasold J, Kreikemeyer B, Mittelmeier W, Podbielski A, Quandt E, Bader R PMID: 26360467 [PubMed - in process] (Source: Biomedizinische Technik/Biomedical Engineering)
Source: Biomedizinische Technik/Biomedical Engineering - December 22, 2015 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Fractal and twin SVM-based handgrip recognition for healthy subjects and trans-radial amputees using myoelectric signal.
In this study, we have computed the signal fractal dimension (FD) and maximum fractal length (MFL) during different grip patterns performed by healthy and transradial amputee subjects. The FD and MFL of the sEMG, referred to as the fractal features, were classified using twin support vector machines (TSVM) to recognize the handgrips. TSVM requires fewer support vectors, is suitable for data sets with unbalanced distributions, and can simultaneously be trained for improving both sensitivity and specificity. When compared with other methods, this technique resulted in improved grip recognition accuracy, sensitivity, and spec...
Source: Biomedizinische Technik/Biomedical Engineering - December 22, 2015 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

How to use current practice, risk analysis and standards to define hospital-wide policies on the safe use of infusion technology.
Authors: Timmerman AM, Oliveira-Martens SM, Snijder RA, Nieman AK, Egberts TC Abstract Infusion therapy is widely used in hospitals. It is well known that medication errors constitute one of the highest risks to patient safety, leading to numerous adverse events concerning incorrect application of infusion technology. Both clinical practice and in vitro studies show that infusion of multiple medications via one access point induces unwanted phenomena such as backflow and an incorrect system response to interventions. Within the Metrology for Drug Delivery project, we addressed the role of infusion devices in drug d...
Source: Biomedizinische Technik/Biomedical Engineering - December 22, 2015 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

In vitro comparison of two changeover methods for vasoactive drug infusion pumps: quick-change versus automated relay.
This study aimed to compare in vitro two syringe changeover techniques to determine which was better at minimising variations in norepinephrine (NE) delivery: the manual quick-change or automated technique. NE concentration was measured continuously using a UV spectrophotometer, and infusion flow rate was monitored by an infusion pump tester. Syringe changeovers were made with either of the two techniques studied. Relays induced disturbances in drug delivery. The temporary increase in NE mass flow rate was significantly higher with manual relays than with automated ones. The automated relay offered a better control of the ...
Source: Biomedizinische Technik/Biomedical Engineering - December 22, 2015 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

An adjustable flow restrictor for implantable infusion pumps based on porous ceramics.
Authors: Jannsen H, Klein S, Nestler B Abstract This paper describes an adjustable flow restrictor for use in gas-driven implantable infusion pumps, which is based on the resistance of a flow through a porous ceramic material. The flow inside the walls of a ceramic tube can be adjusted between 270 nl/min and 1260 nl/min by changing the flow path length in the ceramic over a distance of 14 mm. The long-term stability of the flow restrictor has been analyzed. A drift of -8% from the nominal value was observed, which lies within the required tolerance of ±10% after 30 days. The average time needed to change the flow ...
Source: Biomedizinische Technik/Biomedical Engineering - December 22, 2015 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Primary standard for liquid flow rates between 30 and 1500 nl/min based on volume expansion.
Authors: Lucas P, Ahrens M, Geršl J, Sparreboom W, Lötters J Abstract An increasing number of microfluidic systems operate at flow rates below 1 μl/min. Applications include (implanted) micropumps for drug delivery, liquid chromatography, and microreactors. For the applications where the absolute accuracy is important, a proper calibration is required. However, with standard calibration facilities, flow rate calibrations below ~1 μl/min are not feasible because of a too large calibration uncertainty. In the current research, a traceable flow rate using a certain temperature increase rate is proposed. When the f...
Source: Biomedizinische Technik/Biomedical Engineering - December 22, 2015 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Primary standards for measuring flow rates from 100 nl/min to 1 ml/min - gravimetric principle.
Authors: Bissig H, Petter HT, Lucas P, Batista E, Filipe E, Almeida N, Ribeiro LF, Gala J, Martins R, Savanier B, Ogheard F, Niemann AK, Lötters J, Sparreboom W Abstract Microflow and nanoflow rate calibrations are important in several applications such as liquid chromatography, (scaled-down) process technology, and special health-care applications. However, traceability in the microflow and nanoflow range does not go below 16 μl/min in Europe. Furthermore, the European metrology organization EURAMET did not yet validate this traceability by means of an intercomparison between different National Metrology Institu...
Source: Biomedizinische Technik/Biomedical Engineering - December 22, 2015 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Flow variability and its physical causes in infusion technology: a systematic review of in vitro measurement and modeling studies.
Authors: Snijder RA, Konings MK, Lucas P, Egberts TC, Timmerman AD Abstract Infusion therapy is medically and technically challenging and frequently associated with medical errors. When administering pharmaceuticals by means of infusion, dosing errors can occur due to flow rate variability. These dosing errors may lead to adverse effects. We aimed to systematically review the available biomedical literature for in vitro measurement and modeling studies that investigated the physical causes of flow rate variability. Special focus was given to syringe pump setups, which are typically used if very accurate drug delive...
Source: Biomedizinische Technik/Biomedical Engineering - December 22, 2015 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Low liquid flows - an important aspect in medical technology.
Authors: Klein S, Lucas P PMID: 26352347 [PubMed - in process] (Source: Biomedizinische Technik/Biomedical Engineering)
Source: Biomedizinische Technik/Biomedical Engineering - December 22, 2015 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Brain tumor classification and segmentation using sparse coding and dictionary learning.
Authors: Salman Al-Shaikhli SD, Yang MY, Rosenhahn B Abstract This paper presents a novel fully automatic framework for multi-class brain tumor classification and segmentation using a sparse coding and dictionary learning method. The proposed framework consists of two steps: classification and segmentation. The classification of the brain tumors is based on brain topology and texture. The segmentation is based on voxel values of the image data. Using K-SVD, two types of dictionaries are learned from the training data and their associated ground truth segmentation: feature dictionary and voxel-wise coupled dictionar...
Source: Biomedizinische Technik/Biomedical Engineering - December 22, 2015 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Computational evaluation of amplitude modulation for enhanced magnetic nanoparticle hyperthermia.
Authors: Soetaert F, Dupré L, Ivkov R, Crevecoeur G Abstract Magnetic nanoparticles (MNPs) can interact with alternating magnetic fields (AMFs) to deposit localized energy for hyperthermia treatment of cancer. Hyperthermia is useful in the context of multimodality treatments with radiation or chemotherapy to enhance disease control without increased toxicity. The unique attributes of heat deposition and transfer with MNPs have generated considerable attention and have been the focus of extensive investigations to elucidate mechanisms and optimize performance. Three-dimensional (3D) simulations are often conducted ...
Source: Biomedizinische Technik/Biomedical Engineering - December 22, 2015 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Nonlinear analysis of pupillary dynamics.
Authors: Onorati F, Mainardi LT, Sirca F, Russo V, Barbieri R Abstract Pupil size reflects autonomic response to different environmental and behavioral stimuli, and its dynamics have been linked to other autonomic correlates such as cardiac and respiratory rhythms. The aim of this study is to assess the nonlinear characteristics of pupil size of 25 normal subjects who participated in a psychophysiological experimental protocol with four experimental conditions, namely "baseline", "anger", "joy", and "sadness". Nonlinear measures, such as sample entropy, correlation dimension, and largest Lyapunov exponent, were com...
Source: Biomedizinische Technik/Biomedical Engineering - December 22, 2015 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Modular user interface design for integrated surgical workplaces.
Authors: Benzko J, Krause L, Janß A, Marschollek B, Merz P, Dell'Anna J, Radermacher K Abstract Severe bottlenecks in usability and human technology interaction (HTI) of existing surgical workplaces and operating room (OR) equipment can occur today: lack of space, cable as trip hazard, communication problems between sterile and non-sterile staff, and operating errors in the handling of the medical devices. In fact, risks that are caused by poor usability can be critical, and studies show that most are preventable. This issue gets even more challenging in the context of open-OR networks regarding consistent and usa...
Source: Biomedizinische Technik/Biomedical Engineering - December 22, 2015 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Biomechanical effect of different femoral neck blade position on the fixation of intertrochanteric fracture: a finite element analysis.
Authors: Lee PY, Lin KJ, Wei HW, Hu JJ, Chen WC, Tsai CL, Lin KP Abstract Medial migration or cutout of the neck helical blade has commonly occurred in the treatment of trochanteric fracture of the femur. The position of the helical blade within the femoral head is one of the influencing factors that cause the blade to perforate the intact joint surface; however, the ideal placement of the helical blade is not currently known. A finite element model of a femur/nail construct was utilized to analyze five possible blade positions in the femoral head. Normal strain at the fracture surface, the minimum principal strain...
Source: Biomedizinische Technik/Biomedical Engineering - December 22, 2015 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Means to increase the therapeutic efficiency of magnetic heating of tumors.
In this study, we summarized the present knowledge we gained on how to improve the therapeutic efficiency of magnetic hyperthermia using magnetic nanoparticles (MNPs), with particular consideration of the intratumoral infiltration of the magnetic material. We found that (1) MNPs will be mainly immobilized at the tumor area and that this aspect has to be considered when estimating the heating potential of MNPs, (2) the intratumoral distribution patterns via slow infiltration might well be modulated by specific MNP coating and magnetic targeting, (3) imaging of the nanoparticle depositions within the tumor might allow to cor...
Source: Biomedizinische Technik/Biomedical Engineering - December 22, 2015 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Magnetic nanoparticles for magnetic drug targeting.
Authors: Lyer S, Singh R, Tietze R, Alexiou C Abstract Nanomedicine and superparamagnetic iron oxide nanoparticles (SPIONs) are thought to have an important impact on medicine in the future. Especially in cancer therapy, SPIONs offer the opportunity of improving the effectivity of the treatment and reduce side effects by magnetic accumulation of SPION-bound chemotherapeutics in the tumor area. Although still some challenges have to be overcome, before the new treatment concept of magnetic drug targeting will reach the patients, substantial progress has been made, and promising results were shown in the last years. ...
Source: Biomedizinische Technik/Biomedical Engineering - December 22, 2015 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Performance of a thrombectomy device for aspiration of thrombus with various sizes based on a computational fluid dynamic modeling.
Authors: Soleimani S, Dubini G, Pennati G Abstract It is important to thoroughly remove the thrombus within the course of aspiration thrombectomy; otherwise, it may lead to further embolization. The performance of the aspiration thrombectomy device with a generic geometry is studied through the computational approach. In order to model the thrombus aspiration, a real left coronary artery is chosen while thrombi with various sizes are located at the bifurcation area of the coronary artery and, depending on the size of the thrombus, it is stretched toward the side branches. The thrombus occupies the artery resembling...
Source: Biomedizinische Technik/Biomedical Engineering - December 22, 2015 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

An experimental setup for traceable measurement and calibration of liquid flow rates down to 5 nl/min.
Authors: Ahrens M, Nestler B, Klein S, Lucas P, Petter HT, Damiani C Abstract This work presents the improvements of an experimental setup for measuring ultra-low flow rates down to 5 nl/min. The system uses a telecentric CCD imaging system mounted on a high-precision, computer-controlled linear stage to track a moving liquid meniscus inside a glass capillary. Compared to the original setup, the lowest attainable expanded uncertainty at any flow rate has been reduced from 5.4% to 2%. In addition, the conformity with specification of three commercial micro-fluidic devices was evaluated using the new setup: one syrin...
Source: Biomedizinische Technik/Biomedical Engineering - December 22, 2015 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Magnetic nanoparticles adapted for specific biomedical applications.
Authors: Dutz S, Müller R, Eberbeck D, Hilger I, Zeisberger M Abstract Magnetic nanoparticles (MNPs) are used in different biomedical applications, whereby each application requires specific particle properties. To fulfill these requirements, particle properties have to be optimized by means of variation of crystal structure, particle size, and size distribution. To this aim, improved aqueous precipitation procedures for magnetic iron oxide nanoparticle synthesis were developed. One procedure focused on the cyclic growth of MNPs without nucleation of new particle cores during precipitation. The second novel partic...
Source: Biomedizinische Technik/Biomedical Engineering - December 22, 2015 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

The possibility of using magnetic nanoparticles to increase the therapeutic efficiency of Herceptin antibody.
CONCLUSION: The good results in mice indicated that Herceptin-loaded iron oxide nanoparticles with external magnetic field have good potential for use in humans as a targeted drug delivery that needs more investigation. PMID: 26146093 [PubMed - in process] (Source: Biomedizinische Technik/Biomedical Engineering)
Source: Biomedizinische Technik/Biomedical Engineering - December 22, 2015 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

Influence of calibration method and material on the accuracy of stress distribution measurement systems.
In conclusion, it can be stated that - for the pressure measurement systems compared in this article - the capacitive one is less sensitive to the calibration method and the calibration material than the resistive system. PMID: 26146092 [PubMed - as supplied by publisher] (Source: Biomedizinische Technik/Biomedical Engineering)
Source: Biomedizinische Technik/Biomedical Engineering - December 22, 2015 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research

How physical infusion system parameters cause clinically relevant dose deviations after setpoint changes.
Authors: Timmerman AM, Snijder RA, Lucas P, Lagerweij MC, Radermacher JH, Konings MK Abstract Multi-infusion therapy, in which multiple pumps are connected to one access point, is frequently used in patient treatments. This practice is known to cause dosing errors following setpoint changes in the drug concentrations that actually enter the patients. Within the Metrology for Drug Delivery Project, we analyzed and quantified the two main physical phenomena leading to these errors: the "push-out" effect and the system mechanical compliance. We compared the dosing errors of a three-pump system with two infusion sets, ...
Source: Biomedizinische Technik/Biomedical Engineering - December 22, 2015 Category: Biomedical Engineering Tags: Biomed Tech (Berl) Source Type: research