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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 13.

Brain MR image denoising for Rician noise using pre-smooth non-local means filter
Conclusions: The comparison of the experimental results demonstrates that using a Gaussian pre-smoothing filter and VST produce the best results for the peak signal-to-noise ratio (PSNR) and atrophy detection. (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - January 9, 2015 Category: Biomedical Engineering Authors: Jian YangJingfan FanDanni AiShoujun ZhouSongyuan TangYongtian Wang Source Type: research

Elastic properties of skeletal muscle and subcutaneous tissues in Duchenne muscular dystrophy by magnetic resonance elastography (MRE): A feasibility study
Conclusion: This is the first study to demonstrate muscle altered elastic properties of dystrophic muscle in DMD by MR elastography. Surprisingly, subcutaneous tissue in DMD also showed dramatically altered elastic properties, a new observation which will need further investigation. (Source: IRBM)
Source: IRBM - January 8, 2015 Category: Biomedical Engineering Source Type: research

A new phantom to assess and correct geometrical distortions for Magnetic Resonance Imaging: Design and preliminary experiments
Conclusion: From the promising preliminary results obtained, future developments will include an upgrade of the phantom and the implementation of more sophisticated correction algorithms. (Source: IRBM)
Source: IRBM - January 8, 2015 Category: Biomedical Engineering Source Type: research

Bioaugmentation of half-matured granular sludge with special microbial culture promoted establishment of 2,4-dichlorophenoxyacetic acid degrading aerobic granules.
This study investigated the feasibility of cultivating 2,4-dichlorophenoxyacetic acid (2,4-D) degrading aerobic granules using half-matured sludge granules pre-grown on glucose as the seeds and bioaugmentation with a 2,4-D degrading strain Achromobacter sp. QXH. Results showed that bioaugmentation promoted the steady transformation of glucose-grown granules to 2,4-D degrading sludge granules and fast establishment of 2,4-D degradation ability. The 2,4-D degradation rate of the bioaugmented granules was enhanced by 36-62 % compared to the control at 2,4-D concentrations of 144-565 mg/L on Day 18. The inoculated strain was...
Source: Bioprocess and Biosystems Engineering - January 8, 2015 Category: Biomedical Engineering Authors: Quan X, Ma J, Xiong W, Wang X Tags: Bioprocess Biosyst Eng Source Type: research

Optogenetics Based Rat-Robot Control: Optical Stimulation Encodes "Stop" and "Escape" Commands.
In this study, we first encode "Stop" and "Escape" commands by optical stimulation in the dorsal periaqueductal grey (dPAG). The rats behavioral comparisons are then noted down under these two methods. The dPAG neural activity recorded during optical stimulation suggests rate and temporal coding mechanisms in behavioral control. The behavioral comparisons show that rats exhibit anxiety under the "Stop" command conveyed through both optical and electric methods. However, rats are able to recover more quickly from freezing only under optical "Stop" command. Under "Escape" commands, also conveyed through optical means, the ra...
Source: Annals of Biomedical Engineering - January 8, 2015 Category: Biomedical Engineering Authors: Chen S, Zhou H, Guo S, Zhang J, Qu Y, Feng Z, Xu K, Zheng X Tags: Ann Biomed Eng Source Type: research

Assembly of repetitive regions using next-generation sequencing data
Publication date: Available online 6 January 2015 Source:Biocybernetics and Biomedical Engineering Author(s): Robert Nowak High read depth can be used to assemble short sequence repeats. The existing genome assemblers fail in repetitive regions of longer than average read. I propose a new algorithm for a DNA assembly which uses the relative frequency of reads to properly reconstruct repetitive sequences. The mathematical model for error-free input data shows the upper limits of accuracy of the results as a function of read coverage. For high coverage, the estimation error depends linearly on repetitive sequence length an...
Source: Biocybernetics and Biomedical Engineering - January 7, 2015 Category: Biomedical Engineering Source Type: research

Frequency-Dependence of Mechanically Stimulated Osteoblastic Calcification in Tissue-Engineered Bone In Vitro.
The objective of this study was to investigate the frequency-dependent effect of mechanical loading on osteoblastic calcification in the tissue-engineered bones in vitro. Tissue-engineered bones were constructed by seeding rat osteoblasts into a type I collagen sponge scaffold at a cell density of 1600 or 24,000 cells/mm(3). Sinusoidal compressive deformation at the peak of 0.2% was applied to the tissue-engineered bones at 0.2, 2, 10, 20, 40, and 60 Hz for 3 min/day for 14 consecutive days. Optically-monitored calcium content started to increase on days 5-7 and reached the highest value at 2 Hz on day 14; however, no ...
Source: Annals of Biomedical Engineering - January 7, 2015 Category: Biomedical Engineering Authors: Tanaka SM, Tachibana K Tags: Ann Biomed Eng Source Type: research

Modeling and Analysis of the Viscoelastic Response of the Ankle Ligament Complex in Inversion Ankle Sprain.
In conclusion, by using the viscoelastic properties, sprained ankles were successfully differentiated from uninjured ankles. In clinical application, this method could be a diagnostic tool for quantitative assessment of IAS injury. The stretched exponential function was a useful model to analyze the relaxation behavior. PMID: 25564326 [PubMed - as supplied by publisher] (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - January 7, 2015 Category: Biomedical Engineering Authors: Lin C, Shau Y, Wang C, Kang J Tags: Ann Biomed Eng Source Type: research

Biaxial Creep Resistance and Structural Remodeling of the Aortic and Mitral Valves in Pregnancy.
Abstract Pregnancy produces rapid, dramatic volume-overload changes to the maternal circulation. This paper examines pregnancy-induced structural-mechanical changes in bovine aortic and mitral heart valve leaflets. Valve leaflets were harvested from non-pregnant heifers and pregnant cows. Dimensions, biaxial extensibility and creep resistance were assessed and related to changes in the collagen network: histological leaflet and anatomic layer thicknesses plus collagen crimp, and biochemical collagen content. Collagen stability and crosslinking were assessed thermomechanically. Pregnancy altered both aortic and mitr...
Source: Annals of Biomedical Engineering - January 7, 2015 Category: Biomedical Engineering Authors: Pierlot CM, Moeller AD, Lee JM, Wells SM Tags: Ann Biomed Eng Source Type: research

Bone geometry on the contact stress in the shoulder for evaluation of pressure ulcers: Finite element modeling and experimental validation
This research presents the finite element modeling (FEM) of human-specific computed tomography (CT) data to study the effect of bone prominences on contact stress in the shoulder for prevention of pressure ulcers. The 3D geometry of scapula, skin, and surrounding soft tissues in the shoulder was reconstructed based on the anonymous CT data of a human subject in a prone posture (without loading on the shoulder) for FEM analysis of the contact stress. FEM analysis results show that the maximum stress is located at the prominence of the scapula with sharp bone geometry. (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - January 6, 2015 Category: Biomedical Engineering Authors: Ying Luo, Yancheng Wang, Bruce L. Tai, Roland K. Chen, Albert J. Shih Source Type: research

Industrial vitamin B12 production by Pseudomonas denitrificans using maltose syrup and corn steep liquor as the cost-effective fermentation substrates.
Abstract The aerobic Pseudomonas denitrificans is widely used for industrial and commercial vitamin B12 fermentation, due to its higher productivity compared to the anaerobic vitamin B12-producing microorganisms. This paper aimed to develop a cost-effective fermentation medium for industrial vitamin B12 production by P. denitrificans in 120,000-l fermenter. It was found that maltose syrup (a low-cost syrup from corn starch by means of enzymatic or acid hydrolysis) and corn steep liquor (CSL, a by-product of starch industry) were greatly applicable to vitamin B12 production by P. denitrificans. Under the optimal fer...
Source: Bioprocess and Biosystems Engineering - January 6, 2015 Category: Biomedical Engineering Authors: Xia W, Chen W, Peng W, Li K Tags: Bioprocess Biosyst Eng Source Type: research

Cyclodextrin glycosyltransferase production by free cells of Bacillus circulans DF 9R in batch fermentation and by immobilized cells in a semi-continuous process.
Abstract Cyclodextrin glycosyltransferase (CGTase) catalyzes starch conversion into cyclic or linear oligosaccharides, important industrial products for the complexation of non-polar substances. In this work, conditions to increase CGTase production from Bacillus circulans strain DF 9R were optimized by two systems. On one hand, free cells were grown in batch fermentation experiments to optimize aeration and pH. The highest activity (1.47 ± 0.21 U ml(-1)) was achieved after 48 h of growth, aeration of 1.5 vvm and pH regulated to 7.6. On the other hand, bacterial cells were immobilized on loofa and synthetic ...
Source: Bioprocess and Biosystems Engineering - January 6, 2015 Category: Biomedical Engineering Authors: Costa H, Gastón JR, Lara J, Martinez CO, Moriwaki C, Matioli G, Ferrarotti SA Tags: Bioprocess Biosyst Eng Source Type: research

Cathepsins in Rotator Cuff Tendinopathy: Identification in Human Chronic Tears and Temporal Induction in a Rat Model.
In this study, torn human rotator cuff (supraspinatus) tendon tissue was analyzed for the presence of active cathepsin proteases with multiplex cysteine cathepsin zymography. In addition, an overuse injury to supraspinatus tendons was induced through downhill running in an established rat model. Histological analysis demonstrated that structural damage occurred by 8 weeks of overuse compared to control rats in the region of tendon insertion into bone. In both 4- and 8-week overuse groups, via zymography, there was approximately a 180% increase in cathepsin L activity at the insertion region compared to the controls, while...
Source: Annals of Biomedical Engineering - January 6, 2015 Category: Biomedical Engineering Authors: Seto SP, Parks AN, Qiu Y, Soslowsky LJ, Karas S, Platt MO, Temenoff JS Tags: Ann Biomed Eng Source Type: research

Synergy Between Intercellular Communication and Intracellular Ca(2+) Handling in Arrhythmogenesis.
Abstract Calcium is the primary signalling component of excitation-contraction coupling, the process linking electrical excitability of cardiac muscle cells to coordinated contraction of the heart. Understanding [Formula: see text] handling processes at the cellular level and the role of intercellular communication in the emergence of multicellular synchronization are key aspects in the study of arrhythmias. To probe these mechanisms, we have simulated cellular interactions on large scale arrays that mimic cardiac tissue, and where individual cells are represented by a mathematical model of intracellular [Formula:...
Source: Annals of Biomedical Engineering - January 6, 2015 Category: Biomedical Engineering Authors: Boileau E, George CH, Parthimos D, Mitchell AN, Aziz S, Nithiarasu P Tags: Ann Biomed Eng Source Type: research

The Effects of Oxidative Stress on the Compressive Damage Thresholds of C2C12 Mouse Myoblasts: Implications for Deep Tissue Injury.
In this study, we measured the compressive damage threshold of C2C12 mouse myoblasts with or without pre-treatment of hydrogen peroxide as an oxidative agent to understand how changes in the oxidative environment may contribute to the development of DTI. Spherical indentation was applied onto a layer of agarose gel (3 mm thick) covering a monolayer of C2C12 myoblasts. Cell damage was recognized by using a cell membrane damage assay, propidium iodide. The spatial profile of the measured percentage cell damage was correlated with the radially varying stress field as determined by finite element analysis to estimate the comp...
Source: Annals of Biomedical Engineering - January 6, 2015 Category: Biomedical Engineering Authors: Yao Y, Xiao Z, Wong S, Hsu Y, Cheng T, Chang C, Bian L, Mak AF Tags: Ann Biomed Eng Source Type: research

Virtual Immersion for Post-Stroke Hand Rehabilitation Therapy.
Abstract Stroke is the leading cause of serious, long-term disability in the United States. Impairment of upper extremity function is a common outcome following stroke, often to the detriment of lifestyle and employment opportunities. While the upper extremity is a natural target for therapy, treatment may be hampered by limitations in baseline capability as lack of success may discourage arm and hand use. We developeda virtual reality (VR) system in order to encourage repetitive task practice. This system combined an assistive glove with a novel VR environment. A set of exercises for this system was developed to e...
Source: Annals of Biomedical Engineering - January 6, 2015 Category: Biomedical Engineering Authors: Tsoupikova D, Stoykov NS, Corrigan M, Thielbar K, Vick R, Li Y, Triandafilou K, Preuss F, Kamper D Tags: Ann Biomed Eng Source Type: research

Microparticle-enhanced Aspergillus ficuum phytase production and evaluation of fungal morphology in submerged fermentation.
In conclusion, microparticles significantly increased fungal phytase activity and production yield compared to control fermentation. PMID: 25555703 [PubMed - as supplied by publisher] (Source: Bioprocess and Biosystems Engineering)
Source: Bioprocess and Biosystems Engineering - January 3, 2015 Category: Biomedical Engineering Authors: Coban HB, Demirci A, Turhan I Tags: Bioprocess Biosyst Eng Source Type: research

A kinetic study of textile dyeing wastewater degradation by Penicillium chrysogenum.
Abstract The potential of Penicillium chrysogenum to decolorize azo dyes and a real industrial textile wastewater was studied. P. chrysogenum was able to decolorize and degrade three azo dyes (200 mg L(-1)), either independently or in a mixture of them, using glucose as a carbon source. A kinetic model for degradation was developed and it allowed predicting the degradation kinetics of the mixture of the three azo dyes. In addition, P. chrysogenum was able to decolorize real industrial wastewater. The kinetic model proposed was also able to predict the decolorization of the real wastewater. The calibration of the ...
Source: Bioprocess and Biosystems Engineering - January 3, 2015 Category: Biomedical Engineering Authors: Durruty I, Fasce D, González JF, Wolski EA Tags: Bioprocess Biosyst Eng Source Type: research

Activity classification in persons with stroke based on frequency features
In this study, nine k-nearest neighbor cross-validated classifiers were developed using frequency-features derived from shank-mounted IMUs on the less-affected and affected limbs of subjects with stroke. (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - January 2, 2015 Category: Biomedical Engineering Authors: Annemarie Laudanski, Brenda Brouwer, Qingguo Li Source Type: research

Artificial neural network associated to UV/Vis spectroscopy for monitoring bioreactions in biopharmaceutical processes.
Abstract Currently, mammalian cells are the most utilized hosts for biopharmaceutical production. The culture media for these cell lines include commonly in their composition a pH indicator. Spectroscopic techniques are used for biopharmaceutical process monitoring, among them, UV-Vis spectroscopy has found scarce applications. This work aimed to define artificial neural networks architecture and fit its parameters to predict some nutrients and metabolites, as well as viable cell concentration based on UV-Vis spectral data of mammalian cell bioprocess using phenol red in culture medium. The BHK-21 cell line was use...
Source: Bioprocess and Biosystems Engineering - January 1, 2015 Category: Biomedical Engineering Authors: Takahashi MB, Leme J, Caricati CP, Tonso A, Fernández Núñez EG, Rocha JC Tags: Bioprocess Biosyst Eng Source Type: research

Dependence of fungal characteristics on seed morphology and shear stress in bioreactors.
Abstract The fungal morphology during submerged cultivations has a profound influence on the overall performance of bioreactors. In this research, glucoamylase production by Aspergillus niger has been taken as a model to improve more insights. The morphology engineering could be conducted effectively by changing the seed morphology, as well as specific power input. During the fed-batch cultivations, pellet formation under milder shear stress field helped to reduce the broth viscosity, thus relieving oxygen limitation and promoting the enzyme production. Furthermore, we found that the relation between the shear stre...
Source: Bioprocess and Biosystems Engineering - January 1, 2015 Category: Biomedical Engineering Authors: Lu H, Li C, Tang W, Wang Z, Xia J, Zhang S, Zhuang Y, Chu J, Noorman H Tags: Bioprocess Biosyst Eng Source Type: research

[Front cover / Table of contents]
Presents the table of contents for this issue of this publication. (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - January 1, 2015 Category: Biomedical Engineering Source Type: research

Mentor Program [Advertisement]
Advertisement: IEEE (Source: IEEE Transactions on Biomedical Engineering)
Source: IEEE Transactions on Biomedical Engineering - January 1, 2015 Category: Biomedical Engineering Source Type: research

New Year Message From the Editor-in-Chief
This issue marks the first issue of the 62nd year of IEEE Transactions on Biomedical Engineering . We areworking hard to keep improving the impact and quality of TBME. In 2015, we will continue to promote creativity and innovation and welcome contributions of excellent science that integrates engineering, medicine, and biology. TBME has been ranked in the top 7 among more than 170 biomedical engineering journals according to the H-index. Based on the most recent IEEE Submission-to-ePublication Report, TBME was ranked in the top 20% among 123 IEEE publications. In the last 12 months, TBME received 2066 submissions from 66 c...
Source: IEEE Transactions on Biomedical Engineering - January 1, 2015 Category: Biomedical Engineering Source Type: research

Correction to “A Generic Approach to Pathological Lung Segmentation” [Dec 14 2293-2310]
In the above paper (ibid., vol. 33, no. 12, pp. 2293-2310, Dec. 2014), Awais Mansoor was incorrectly indicated as the corresponding author. Ulas Bagci should have been indicated as the corresponding author. (Source: IEE Transactions on Medical Imaging)
Source: IEE Transactions on Medical Imaging - January 1, 2015 Category: Biomedical Engineering Source Type: research

Acknowledgement to Reviewers 2014
(Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - January 1, 2015 Category: Biomedical Engineering Source Type: research

Editorial Board
(Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - January 1, 2015 Category: Biomedical Engineering Source Type: research

Review of 2014: Jack Perkins Prize, Journal Impact Factor, and Editorial Board of Medical Engineering & Physics
The winners of the 2014 Jack Perkins Prize were announced in September at the annual Medical Physics and Engineering Conference (MPEC2014), which took place at the Scottish Exhibition and Conference Centre in Glasgow, Scotland, UK. They are Shaoyu Qiao and Ken Yoshida of Indiana University/Purdue University, IN, USA, for their paper entitled: (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - January 1, 2015 Category: Biomedical Engineering Authors: Richard A. Black Tags: Editorial Source Type: research

Rotary Blood Pump Control Strategy for Preventing Left Ventricular Suction
The risk for left ventricular (LV) suction while maintaining adequate perfusion over a range of physiologic conditions during continuous flow LV assist device (LVAD) support is a significant clinical concern. To address this challenge, we developed a suction prevention and physiologic control (SPPC) algorithm for use with axial and centrifugal LVADs. The SPPC algorithm uses two gain-scheduled, proportional-integral controllers that maintain a differential pump speed (ΔRPM) above a user-defined threshold to prevent LV suction, while maintaining an average reference differential pressure (ΔP) between the LV and aorta to pr...
Source: ASAIO Journal - December 31, 2014 Category: Medical Equipment Tags: Biomedical Engineering Source Type: research

X-ray examination of integrated stent markers
Conclusion: Using laser micro-manufactured markers integrated in the stent struts, the stent's X-ray visibility can be increased. By examining the X-ray microscopic images, a calibration diagram describing the relation between the individual pixels' level of grayness and their material thickness can be concluded. The volume of the individual markers can be determined using this diagram that describes the marker area separated on the images and the material thickness. (Source: IRBM)
Source: IRBM - December 31, 2014 Category: Biomedical Engineering Source Type: research

Automatic Classification and Quantification of Cell Adhesion Locations on the Endothelium.
Abstract To target tumor hematogenous metastasis and to understand how leukocytes cross the microvessel wall to perform immune functions, it is necessary to elucidate the adhesion location and transmigration pathway of tumor cells and leukocytes on/across the endothelial cells forming the microvessel wall. We developed an algorithm to classify and quantify cell adhesion locations from photomicrographs taken from the experiments of tumor cell/leukocyte adhesion in individual microvessels. The first step is to identify the microvessel by a novel gravity-field dynamic programming (DP) procedure. Next, an anisotropic i...
Source: Annals of Biomedical Engineering - December 31, 2014 Category: Biomedical Engineering Authors: Wei J, Cai B, Zhang L, Fu BM Tags: Ann Biomed Eng Source Type: research

Effects of Polypropylene Carbonate/Poly(D,L-lactic) Acid/Tricalcium Phosphate Elastic Composites on Improving Osteoblast Maturation.
In this study, we developed a new PPC-derived composite by mixing poly-lactic acid (PLA) and tricalcium phosphate (TCP), called PPC/PLA/TCP elastic (PPTE) scaffolds. We also evaluated the beneficial effects of PPTE composites on osteoblast growth and maturation and the possible mechanisms. Compared to PPC polymers, PPTE composites had similar pore sizes and porosities but possessed better hydrophilic surface structures. Biological evaluations further revealed that PPTE composites attracted adhesion of mouse osteoblasts, and these bone cells extended along the porous scaffolds to produce accurate fibroblast-like morphologie...
Source: Annals of Biomedical Engineering - December 31, 2014 Category: Biomedical Engineering Authors: Fang H, Kao W, Lin P, Chang G, Hung Y, Chen R Tags: Ann Biomed Eng Source Type: research

pyNS: An Open-Source Framework for 0D Haemodynamic Modelling.
Abstract A number of computational approaches have been proposed for the simulation of haemodynamics and vascular wall dynamics in complex vascular networks. Among them, 0D pulse wave propagation methods allow to efficiently model flow and pressure distributions and wall displacements throughout vascular networks at low computational costs. Although several techniques are documented in literature, the availability of open-source computational tools is still limited. We here present python Network Solver, a modular solver framework for 0D problems released under a BSD license as part of the archToolkit ( http://arch...
Source: Annals of Biomedical Engineering - December 31, 2014 Category: Biomedical Engineering Authors: Manini S, Antiga L, Botti L, Remuzzi A Tags: Ann Biomed Eng Source Type: research

Validity and Reliability of Gait and Postural Control Analysis Using the Tri-axial Accelerometer of the iPod Touch.
Abstract Accelerometer-based assessments can identify elderly with an increased fall risk and monitor interventions. Smart devices, like the iPod Touch, with built-in accelerometers are promising for clinical gait and posture assessments due to easy use and cost-effectiveness. The aim of the present study was to establish the validity and reliability of the iPod Touch for gait and posture assessment. Sixty healthy participants (aged 18-75 years) were measured with an iPod Touch and stand-alone accelerometer while they walked under single- and dual-task conditions, and while standing in parallel and semi-tandem sta...
Source: Annals of Biomedical Engineering - December 31, 2014 Category: Biomedical Engineering Authors: Kosse NM, Caljouw S, Vervoort D, Vuillerme N, Lamoth CJ Tags: Ann Biomed Eng Source Type: research