Biomedical Engineering This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.
This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 13.
Pullout performance comparison of pedicle screws based on cement application and design parameters
This study concentrates on the usage of dual lead dual core with cement augmentation as an alternative to cannulated and standard pedicle screws with cement augmentation. Five groups (dual lead dual core, normal pedicle screw and cannulated pedicle screw with augmentation, normal pedicle screw, dual lead dual cored pedicle screw) were designed for this study. Healthy bovine vertebrae and synthetic polyurethane foams (grade 20) were used as embedding test medium. Test samples were prepared in accordance with surgical guidelines and ASTM F543 standard testing protocols. Pullout tests were conducted with Instron 3300 testing ...
Source: Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine - October 25, 2015 Category: Biomedical Engineering Authors: Tolunay, T., Basgül, C., Demir, T., Yaman, M. E., Arslan, A. K. Tags: Original Articles Source Type: research
Analysis of the structural behaviour of colonic segments by inflation tests: Experimental activity and physio-mechanical model
A coupled experimental and computational approach is provided for the identification of the structural behaviour of gastrointestinal regions, accounting for both elastic and visco-elastic properties. The developed procedure is applied to characterize the mechanics of gastrointestinal samples from pig colons. Experimental data about the structural behaviour of colonic segments are provided by inflation tests. Different inflation processes are performed according to progressively increasing top pressure conditions. Each inflation test consists of an air in-flow, according to an almost constant increasing pressure rate, such ...
Source: Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine - October 25, 2015 Category: Biomedical Engineering Authors: Carniel, E. L., Mencattelli, M., Bonsignori, G., Fontanella, C. G., Frigo, A., Rubini, A., Stefanini, C., Natali, A. N. Tags: Original Articles Source Type: research
Lessons from retrievals: Retrievals help understand the reason for revision of coated hip arthroplasties
Coatings have been applied to all surfaces of hip implants with the majority performing well in the laboratory, but there are few reports of their performance in humans. The rationale for coating the metal-on-metal bearing surfaces includes a reduction in metal ion release and risk of adverse reaction to metal debris; yet there are no reports of retrieved coated metal-on-metal hip implants despite the concern that they may delaminate. The aim of this study was to better understand the performance of coated hip implants in humans through findings of three coated metal-on-metal hip resurfacings, retrieved after failure for u...
Source: Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine - October 25, 2015 Category: Biomedical Engineering Authors: de Villiers, D., Hothi, H., Khatkar, H., Meswania, J., Blunn, G., Skinner, J., Hart, A. Tags: Original Articles Source Type: research
Global and segmental kinematic changes following sequential resection of posterior osteoligamentous structures in the lumbar spine: An in vitro biomechanical investigation using pure moment testing protocols
Lumbar spinal surgeries may compromise the integrity of posterior osteoligamentous structures implicating mechanical stability. Circumstances necessitating a concomitant surgery to achieve restabilisation are not well understood. The main objective of this in vitro study was to quantify global and segmental (index and adjacent levels) kinematic changes in the lumbar spine following sequential resection of the posterior osteoligamentous structures using pure moment testing protocols. Six fresh frozen cadaveric kangaroo lumbar spines (T12–S1) were tested under a bending moment in flexion–extension, bilateral bend...
Source: Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine - October 25, 2015 Category: Biomedical Engineering Authors: Chamoli, U., Korkusuz, M. H., Sabnis, A. B., Manolescu, A. R., Tsafnat, N., Diwan, A. D. Tags: Technical Note Source Type: research
Time-multiplexed two-channel capacitive radiofrequency hyperthermia with nanoparticle mediation
Conclusions: Time-multiplexed two-channel capacitive RF heating has the capability to better localize heat transfer to the nanoparticle-mediated tumor region which has higher electrical conductivity than the background normal tissues. (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - October 24, 2015 Category: Biomedical Engineering Authors: Ki KimDaniel HernandezSoo Lee Source Type: research
A framework for retinal vasculature segmentation based on matched filters
Conclusion: The performance of the proposed method is significantly better than almost all unsupervised methods, in addition, comparable to most of the existing supervised vasculature segmentation methods. (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - October 24, 2015 Category: Biomedical Engineering Authors: Xianjing MengYilong YinGongping YangZhe HanXiaowei Yan Source Type: research
Treatment of patients with type 1 diabetes – Insulin pumps or multiple injections?
The objective of this review is to discuss the most important factors contributing to this situation. We made a comprehensive evidence-based review of the factors affecting effectiveness of CSII and MDI, with a special attention to algorithms for insulin dose adjustments and the automatic bolus calculators. Regardless of the treatment regimen that is used a few different interdependent factors influence the final result of the intensive insulin therapy. These factors comprise: patients’ education, attitude, emotional stability and compliance, and careful analysis of the treatment results by a physician establishing the a...
Source: Biocybernetics and Biomedical Engineering - October 24, 2015 Category: Biomedical Engineering Source Type: research
Determining the mechanical properties of electrospun poly-ε-caprolactone (PCL) nanofibers using AFM and a novel fiber anchoring technique
Publication date: 1 February 2016 Source:Materials Science and Engineering: C, Volume 59 Author(s): Stephen R. Baker, Soham Banerjee, Keith Bonin, Martin Guthold Due to its low cost, biocompatibility and slow bioresorption, poly-ε-caprolactone (PCL) continues to be a suitable material for select biomedical engineering applications. We used a combined atomic force microscopy (AFM)/optical microscopy technique to determine key mechanical properties of individual electrospun PCL nanofibers with diameters between 440–1040nm. Compared to protein nanofibers, PCL nanofibers showed much lower adhesion, as they slipped on ...
Source: Materials Science and Engineering: C - October 24, 2015 Category: Materials Science Source Type: research
Motion tracking and gait feature estimation for recognising Parkinson’s disease using MS Kinect
Conclusions: Discussion points include the possibility of using the MS Kinect sensors as inexpensive replacements for complex multi-camera systems and treadmill walking in gait-feature detection for the recognition of selected gait disorders. (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - October 24, 2015 Category: Biomedical Engineering Authors: Ond¿ej ¿upaAle¿ ProcházkaOld¿ich Vy¿ataMartin SchätzJan Mare¿Martin Vali¿Vladimír Ma¿ík Source Type: research
Quantification of confocal fluorescence microscopy for the detection of cervical intraepithelial neoplasia
Conclusions: Quantitative analysis of confocal fluorescence images showed its capacity for discriminating high-grade CIN lesions vs. low-grade CIN lesions and normal tissues, at different depth of imaging. This approach could be used to help clinicians identify high-grade CIN in clinical settings. (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - October 24, 2015 Category: Biomedical Engineering Authors: Fahime SheikhzadehRabab WardAnita CarraroZhao ChenDirk van NiekerkDianne MillerTom EhlenCalum MacAulayMichele FollenPierre LaneMartial Guillaud Source Type: research
A lipase with broad solvent stability from Burkholderia cepacia RQ3: isolation, characteristics and application for chiral resolution of 1-phenylethanol.
Abstract Using both polar and low polar organic solvents (DMSO and toluene) as screening stress, a solvent-stable bacterium Burkholderia cepacia RQ3 was newly isolated. An organic solvent-stable lipase from strain RQ3 was purified in a single step with 50.1 % recovery by hydrophobic chromatography. The purified lipase was homogenous on SDS-PAGE and had an apparent molecular mass of 33 kDa. The gene of lipase RQ3 with an open reading frame of 1095 bp encoding 364-amino acid residues was cloned. The optimal pH and temperature for lipase activity were 9.0 and 40 °C. The lipase was stable in a wide pH range of 6.0...
Source: Bioprocess and Biosystems Engineering - October 24, 2015 Category: Biomedical Engineering Authors: Xie C, Wu B, Qin S, He B Tags: Bioprocess Biosyst Eng Source Type: research
Modeling of interstitial fluid movement in soft tissue under negative pressure - relevance to treatment of tissue swelling.
Abstract Exact physiological mechanisms behind the potential positive treatment effects of pathological tissue swelling (edema), such as increased interstitial fluid flow, are poorly understood. Finite-element model was created and the model response was matched with the deformation data from the negative pressure (suction) measurements in human (N = 11) forearm. Two experimental suction protocols were simulated to evaluate their impact on interstitial fluid flow in soft tissues. Simulated continuous suction was up to 27 times more efficient in fluid transportation compared to the cyclic suction. The continuous s...
Source: Computer Methods in Biomechanics and Biomedical Engineering - October 24, 2015 Category: Biomedical Engineering Authors: Iivarinen JT, Korhonen RK, Jurvelin JS Tags: Comput Methods Biomech Biomed Engin Source Type: research
A simple microfluidic device for the deformability assessment of blood cells in a continuous flow.
Abstract Blood flow presents several interesting phenomena in microcirculation that can be used to develop microfluidic devices capable to promote blood cells separation and analysis in continuous flow. In the last decade there have been numerous microfluidic studies focused on the deformation of red blood cells (RBCs) flowing through geometries mimicking microvessels. In contrast, studies focusing on the deformation of white blood cells (WBCs) are scarce despite this phenomenon often happens in the microcirculation. In this work, we present a novel integrative microfluidic device able to perform continuous separat...
Source: Biomedical Microdevices - October 23, 2015 Category: Biomedical Engineering Authors: Rodrigues RO, Pinho D, Faustino V, Lima R Tags: Biomed Microdevices Source Type: research
Increased minimum toe clearance variability in patients with peripheral arterial disease
The most common symptom of peripheral arterial disease (PAD) is intermittent claudication , which is characterized by a cramping type of muscle pain in the lower extremities brought on by physical activity and relieved with rest. As 12–20% of all individuals 60 years of age and older  are afflicted with PAD, and falls are a primary source of injury and death among the elderly, falls are an additional concern in this patient population. Not surprisingly, reports estimate that individuals with PAD experience 73% more falls than their healthy counterparts along with a greater prevalence of ambulatory stumbling and ove...
Source: Medical Engineering and Physics - October 23, 2015 Category: Biomedical Engineering Authors: Troy J. Rand, Shane R. Wurdeman, Jason M. Johanning, Iraklis I. Pipinos, Sara A. Myers Source Type: research
Estimation of heart rate variability using a compact radiofrequency motion sensor
Rapid increases in social security budgets caused by aging of the population and the high costs of sophisticated medical technology are significant problems in many developed countries. To improve this situation, measures that help people exert greater control over healthcare and prevent diseases before they occur are needed. Blood pressure monitors and weight or body fat scales are good devices to manage people's health. However, sustained monitoring is needed to assess health conditions, and the information obtained from these devices is insufficient to protect against a number of diseases. (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - October 23, 2015 Category: Biomedical Engineering Authors: Norihiro Sugita, Narumi Matsuoka, Makoto Yoshizawa, Makoto Abe, Noriyasu Homma, Hideharu Otake, Junghyun Kim, Yukio Ohtaki Source Type: research
Abdomen disease diagnosis in CT images using flexiscale curvelet transform and improved genetic algorithm
Abstract This paper presents an abdomen disease diagnostic system based on the flexi-scale curvelet transform, which uses different optimal scales for extracting features from computed tomography (CT) images. To optimize the scale of the flexi-scale curvelet transform, we propose an improved genetic algorithm. The conventional genetic algorithm assumes that fit parents will likely produce the healthiest offspring that leads to the least fit parents accumulating at the bottom of the population, reducing the fitness of subsequent populations and delaying the optimal solution search. In our improved genetic algorithm...
Source: Australasian Physical and Engineering Sciences in Medicine - October 23, 2015 Category: Biomedical Engineering Source Type: research
Lignocellulose degrading extremozymes produced by Pichia pastoris: current status and future prospects.
Abstract In this review article, extremophilic lignocellulosic enzymes with special interest on xylanases, β-mannanases, laccases and finally cellulases, namely, endoglucanases, exoglucanases and β-glucosidases produced by Pichia pastoris are reviewed for the first time. Recombinant lignocellulosic extremozymes are discussed from the perspectives of their potential application areas; characteristics of recombinant and native enzymes; the effects of P. pastoris expression system on recombinant extremozymes; and their expression levels and applied strategies to increase the enzyme expression yield. Further, effects...
Source: Bioprocess and Biosystems Engineering - October 23, 2015 Category: Biomedical Engineering Authors: Gündüz Ergün B, Çalık P Tags: Bioprocess Biosyst Eng Source Type: research
Effects of Vessel Tortuosity on Coronary Hemodynamics: An Idealized and Patient-Specific Computational Study.
Abstract Although coronary tortuosity can influence the hemodynamics of coronary arteries, the relationship between tortuosity and flow has not been thoroughly investigated partly due to the absence of a widely accepted definition of tortuosity and the lack of patient-specific studies that analyze complete coronary trees. Using a computational approach we investigated the effects of tortuosity on coronary flow parameters including pressure drop, wall shear stress, and helical flow strength as measured by helicity intensity. Our analysis considered idealized and patient-specific geometries. Overall results indicate ...
Source: Annals of Biomedical Engineering - October 23, 2015 Category: Biomedical Engineering Authors: Vorobtsova N, Chiastra C, Stremler MA, Sane DC, Migliavacca F, Vlachos P Tags: Ann Biomed Eng Source Type: research
Bioinspired enzymatic synthesis of silica nanocrystals provided by recombinant silicatein from the marine sponge Latrunculia oparinae.
Abstract The process of silica formation in marine sponges is thought to be mediated by a family of catalytically active structure-directing enzymes called silicateins. It has been demonstrated in biomimicking syntheses that silicateins facilitated the formation of amorphous SiO2. Here, we present evidence that the silicatein LoSiLA1 from the marine sponge Latrunculia oparinae catalyzes the in vitro synthesis of hexa-tetrahedral SiO2 crystals of 200-300 nm. This was possible in the presence of the silica precursor tetrakis-(2-hydroxyethyl)-orthosilicate that is completely soluble in water and biocompatible, experi...
Source: Bioprocess and Biosystems Engineering - October 22, 2015 Category: Biomedical Engineering Authors: Shkryl YN, Bulgakov VP, Veremeichik GN, Kovalchuk SN, Kozhemyako VB, Kamenev DG, Semiletova IV, Timofeeva YO, Shchipunov YA, Kulchin YN Tags: Bioprocess Biosyst Eng Source Type: research
Low Shear Stress Inhibited Endothelial Cell Autophagy Through TET2 Downregulation.
In this study, the effect of low shear stress on endothelial cell autophagy and its potential mechanism were investigated. Results showed autophagy dysfunction and ten-eleven translocation 2 (TET2) protein downregulation during atherosclerotic lesion progression. Autophagic markers BECLIN 1 and LC3II/LC3I under low shear stress (5 dyne/cm(2)) obviously decreased compared with those under physiological shear stress (15 dyne/cm(2)), whereas autophagic substrate p62 increased. TET2 expression was also downregulated under low shear stress. Endothelial cell autophagy was improved with TET2 overexpression but was impaired by T...
Source: Annals of Biomedical Engineering - October 22, 2015 Category: Biomedical Engineering Authors: Yang Q, Li X, Li R, Peng J, Wang Z, Jiang Z, Tang X, Peng Z, Wang Y, Wei D Tags: Ann Biomed Eng Source Type: research
A novel channel selection method for optimal classification in different motor imagery BCI paradigms
Conclusions: It is demonstrated that IterRelCen has a strong ability for feature selection. In addition, the results have shown that the numbers of optimal channels in the three different motor imagery BCI paradigms are distinct. From a MI task paradigm, to a two-class control paradigm, and to a four-class control paradigm, the number of required channels for optimizing the classification accuracy increased. These findings may provide useful information to optimize EEG based BCI systems, and further improve the performance of noninvasive BCI. (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - October 21, 2015 Category: Biomedical Engineering Authors: Haijun ShanHaojie XuShanan ZhuBin He Source Type: research
A model microfluidics-based system for the human and mouse retina.
Abstract The application of microfluidics technologies to the study of retinal function and response holds great promise for development of new and improved treatments for patients with degenerative retinal diseases. Restoration of vision via retinal transplantation therapy has been severely limited by the low numbers of motile cells observed post transplantation. Using modern soft lithographic techniques, we have developed the μRetina, a novel and convenient biomimetic microfluidics device capable of examing the migratory behavior of retinal lineage cells within biomimetic geometries of the human and mouse retina...
Source: Biomedical Microdevices - October 20, 2015 Category: Biomedical Engineering Authors: Mishra S, Thakur A, Redenti S, Vazquez M Tags: Biomed Microdevices Source Type: research
Modelling the effects of cerebral microvasculature morphology on oxygen transport
Estimates of cerebral blood flow (CBF), mean transit time (MTT), oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) using imaging modalities have been widely used in clinical studies to diagnose ischaemic lesions, where CBF is the flow of blood per volume of tissue, MTT is the ratio of the cerebral blood volume (CBV) to CBF, with CBV being the volume of blood per volume of tissue, OEF is the fraction of oxygen removed from the blood in the capillary network by the tissue and CMRO2 is the product of CBF and OEF. (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - October 20, 2015 Category: Biomedical Engineering Authors: Chang Sub Park, Stephen J. Payne Source Type: research
An Effective Approach for Optimization of a Composite Intramedullary Nail for Treating Femoral Shaft Fractures
This study proposes a number of practical guidelines for the design of composite IM nails. (Source: Journal of Biomechanical Engineering)
Source: Journal of Biomechanical Engineering - October 20, 2015 Category: Biomedical Engineering Source Type: research
The first Rs of radiotherapy: or standing on the shoulders of giants
Abstract The name of the Australian-born professor, Rodney H. Withers, is highly acknowledged among radiation biologists, radiation oncologists, medical physicists and other professionals. The list of his contributions towards knowledge enhancement and better understanding of the biological basis for radiotherapy is a long one. However, there are certain landmarks of Dr. Withers’ research that are worth emphasizing, as they have marked several paths along the development of radiotherapy: the four Rs of radiotherapy, the accelerated tumour growth during treatment, the time-factor in radiotherapy, altered fraction...
Source: Australasian Physical and Engineering Sciences in Medicine - October 20, 2015 Category: Biomedical Engineering Source Type: research
Development of a two-step process for production of 3-hydroxypropionic acid from glycerol using Klebsiella pneumoniae and Gluconobacter oxydans.
Abstract In this work, a two-step process was developed for the production of 3-hydroxypropionic acid from glycerol. In the first step, glycerol was converted to 1,3-propanediol by Klebsiella pneumonia. In the second step, the 1,3-propanediol was converted into 3-hydroxypropionic acid by Gluconobacter oxydans. In a 7.0 L bioreactor, the whole process took 54 h, consumed 480 g glycerol and produced 242 g 3-hydroxypropionic acid. The conversion rate of glycerol to 3-hydroxypropionic acid was 50.4 % (g g(-1)). The final concentration of 3-hydroxypropionic acid arrived 60.5 g L(-1). The process was effective for ...
Source: Bioprocess and Biosystems Engineering - October 20, 2015 Category: Biomedical Engineering Authors: Zhao L, Lin J, Wang H, Xie J, Wei D Tags: Bioprocess Biosyst Eng Source Type: research
X-ray Phase Contrast Allows Three Dimensional, Quantitative Imaging of Hydrogel Implants.
Abstract Three dimensional imaging techniques are needed for the evaluation and assessment of biomaterials used for tissue engineering and drug delivery applications. Hydrogels are a particularly popular class of materials for medical applications but are difficult to image in tissue using most available imaging modalities. Imaging techniques based on X-ray Phase Contrast (XPC) have shown promise for tissue engineering applications due to their ability to provide image contrast based on multiple X-ray properties. In this manuscript, we investigate the use of XPC for imaging a model hydrogel and soft tissue structur...
Source: Annals of Biomedical Engineering - October 20, 2015 Category: Biomedical Engineering Authors: Appel AA, Larson JC, Jiang B, Zhong Z, Anastasio MA, Brey EM Tags: Ann Biomed Eng Source Type: research
Webbing and Delamination of Drug Eluting Stent Coatings.
Abstract The advancement of the drug-eluting stent technology raises the significant challenge of safe mechanical design of polymer coated stent systems. Experimental images of stent coatings undergoing significant damage during deployment have been reported; such coating damage and delamination can lead to complications such as restenosis and increased thrombogenicity. In the current study a cohesive zone modeling framework is developed to predict coating delamination and buckling due to hinge deformation during stent deployment. Models are then extended to analyze, for the first time, stent-coating damage due to ...
Source: Annals of Biomedical Engineering - October 20, 2015 Category: Biomedical Engineering Authors: Hopkins C, Sweeney CA, O'Connor C, McHugh PE, McGarry JP Tags: Ann Biomed Eng Source Type: research
The influence of storage and heat treatment on a magnesium-based implant material: an in vitro and in vivo study
Conclusions: LAE442 implants can be safely used after up to 48 weeks of storage. (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - October 19, 2015 Category: Biomedical Engineering Authors: Katja BrachtNina AngrisaniJan-Marten SeitzRainer EiflerAndreas WeizbauerJanin Reifenrath Source Type: research
Application of analyzer based X-ray imaging technique for detection of ultrasound induced cavitation bubbles from a physical therapy unit
Conclusion: This set of experiments demonstrates the utility of synchrotron ABI for visualizing cavitation bubbles formed in water by clinical ultrasound systems working at high frequency and output powers as low as a therapeutic system. (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - October 19, 2015 Category: Biomedical Engineering Authors: Zahra IzadifarGeorge BelevPaul BabynDean Chapman Source Type: research
Radiation dose measurements of an on-board imager X-ray unit using optically-stimulated luminescence dosimeters
In this study, we have used commercially available optically stimulated luminescence (OSLD) dosimeters to measure the dose delivered by the Varian OBI on a radiotherapy linear accelerator. Calibration of the OSLDs was achieved by using a therapeutic X-ray unit. The dose delivered by a head CBCT scan was found to be 3.2 ± 0.3 mGy which is similar in magnitude to the dose of a head computed tomography (CT) scan. The results of this study suggest that the radiation hazard associated with CBCT is of a similar nature to that of conventional CT scans. We have also demonstrated that the OSLDs are suitable for these low X-ray ...
Source: Australasian Physical and Engineering Sciences in Medicine - October 19, 2015 Category: Biomedical Engineering Source Type: research
Reducing shield thickness and backscattered radiation using a multilayered shield for 6–10 MeV electron beams
Abstract Intraoral and external electron shields used in radiotherapy are designed to minimize radiation exposure to non-treatment tissue. Sites where shields are used include but are not limited to, the treatment of lips, cheeks and ears whilst shielding the underlying oral cavity, tongue, gingival or temporal region. A commonly known and published effect, concerns the enhancement in dose that can occur on the beam side on an electron shield caused by an increase in electron backscatter radiation. In this work a lead shield has been designed incorporating copper, aluminium and wax in a step down filter arrangemen...
Source: Australasian Physical and Engineering Sciences in Medicine - October 19, 2015 Category: Biomedical Engineering Source Type: research
A rapid compression technique for 4-D functional MRI images using data rearrangement and modified binary array techniques
The objective results showed that the proposed method could gain good compression ratio in maintaining a peak signal noise ratio value of above 70 for all the experimented sequences. The SSIM value is equal to 1 and the value of CC is greater than 0.9 for all experiments. Subjective evaluation on the reconstructed images indicated that the proposed method could reproduce the diagnostic features of fMRI images clearly. (Source: Australasian Physical and Engineering Sciences in Medicine)
Source: Australasian Physical and Engineering Sciences in Medicine - October 19, 2015 Category: Biomedical Engineering Source Type: research
The formation and function of the sclerosis rim in the femoral head: A biomechanical point of view
Osteonecrosis of the femoral head (ONFH) is a progressive disease leading to destruction of the hip joint . There is a general agreement that the size and location of a necrotic lesion are important factors in predicting femoral head collapse [2–5]. However the role of the sclerosis rim (see Fig. 1) commonly found in necrotic femoral head in the natural history of osteonecrosis has not yet been given enough attention it deserves. A retrospective analysis of the sclerosis rim in patients with ONFH showed that the time from hip pain to joint replacement was 49 ± 11 months in patients with sclerosis rim, and 15 ± 2...
Source: Medical Engineering and Physics - October 19, 2015 Category: Biomedical Engineering Authors: ZhiPing Chen, Yong Xu, ZhenXi Qi, JinShui Zho Source Type: research
Biodiesel production potential of mixed microalgal culture grown in domestic wastewater.
In this study, a mixed microalgal culture grown in secondarily treated domestic wastewater effluent was investigated for biodiesel production using in situ transesterification method with conventional heating. The total lipid content of the mixed culture was found as 26.2 % ± 0.6 by weight of dry biomass, and 74 % of the lipids were contributed by total glycerides. In situ transesterification with conventional heating process under acidic conditions produced higher biodiesel yield with chloroform as the co-solvent (82.1 % ± 3.9) compared to hexane (55.3 % ± 3.9) under the same reaction conditions. The gas chro...
Source: Bioprocess and Biosystems Engineering - October 19, 2015 Category: Biomedical Engineering Authors: Soydemir G, Keris-Sen UD, Sen U, Gurol MD Tags: Bioprocess Biosyst Eng Source Type: research
Selective pattern of cancer cell accumulation and growth using UV modulating printing of hydrogels.
Abstract Fabrication of extracellular microenvironment for cancer cell growth in vitro is an indispensable technique to precisely control the cell spatial arrangement and proliferation for cell-behavior research. Current micropatterning methods usually require relatively complicated operations, which makes it difficult to investigate the effects of different cell growth patterns. This manuscript proposes a DMD-based projection technique to quickly pattern a poly(ethylene) glycol diacrylate (PEGDA)-based hydrogel on a common glass substrate. Using this method, we can effectively control the growth patterns of cells....
Source: Biomedical Microdevices - October 18, 2015 Category: Biomedical Engineering Authors: Yang W, Yu H, Wei F, Li G, Wang Y, Liu L Tags: Biomed Microdevices Source Type: research
Fabrication of uniform-sized poly-ɛ-caprolactone microspheres and their applications in human embryonic stem cell culture.
Abstract The generation of liquefied poly-ɛ-caprolactone (PCL) droplets by means of a microfluidic device results in uniform-sized microspheres, which are validated as microcarriers for human embryonic stem cell culture. Formed droplet size and size distribution, as well as the resulting PCL microsphere size, are correlated with the viscosity and flow rate ratio of the dispersed (Q d) and continuous (Q c) phases. PCL in dichloromethane increases its viscosity with concentration and molecular weight. Higher viscosity and Q d/Q c lead to the formation of larger droplets, within two observed formation modes: dripping...
Source: Biomedical Microdevices - October 18, 2015 Category: Biomedical Engineering Authors: Li J, Lam AT, Toh JP, Reuveny S, Oh SK, Birch WR Tags: Biomed Microdevices Source Type: research