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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 13.

Blind Received Signal Strength Difference Based Source Localization With System Parameter Errors
The problem of passive source localization has been extensively studied due to its many applications in signal processing and wireless communications. Signal strength-based localization methods have the advantages of low cost and simple implementation. In this paper, blind source localization with unknown transmit power and unknown path loss exponent is considered based on the received signal strength difference (RSSD). A nonlinear RSSD-based model is formulated for systems perturbed by noise. Solutions obtained using conventional least squares methods suffer from significant performance degradation as they only consider e...
Source: IEEE Transactions on Signal Processing - August 12, 2014 Category: Biomedical Engineering Source Type: research

Phase Only RF Precoding for Massive MIMO Systems With Limited RF Chains
Massive MIMO systems promise high spectrum efficiency by deploying $M gg 1$ antennas at the base station (BS). However, to achieve the full gain provided by massive MIMO, the BS requires $M$ radio frequency (RF) chains, which are expensive. This motivates us to consider RF-chain limited massive MIMO systems with $M$ antennas but only $S ll M$ RF chains. We propose a two-stage precoding scheme to efficiently exploit the large spatial degree of freedom (DoF) gain in massive MIMO systems with limited RF chains and reduced channel state information (CSI) signaling overhead. In this scheme, the MIMO precoder is partitioned into...
Source: IEEE Transactions on Signal Processing - August 12, 2014 Category: Biomedical Engineering Source Type: research

Fundamental Limits of HRR Profiling and Velocity Compensation for Stepped-Frequency Waveforms
A stepped-frequency (SF) waveform is effective in achieving high-range resolution (HRR) in modern radars. In this paper, we determine various fundamental limits of the SF waveform regarding the ambiguity, stability, and accuracy of stationary target profiling and the velocity compensation accuracy for moving targets. The investigation reveals that by using the information contained in both the phase and envelope of the echo signal, SF radars can achieve HRR profiles without ambiguity under a looser criterion and can compensate the range shift caused by a target's radial velocity. The results of this paper can aid in SF wav...
Source: IEEE Transactions on Signal Processing - August 12, 2014 Category: Biomedical Engineering Source Type: research

Table of Contents
(Source: IEEE Transactions on Signal Processing)
Source: IEEE Transactions on Signal Processing - August 12, 2014 Category: Biomedical Engineering Source Type: research

Monolithic superelastic rods with variable flexural stiffness for spinal fusion: Modeling of the processing–properties relationship
The concept of a monolithic Ti–Ni spinal rod with variable flexural stiffness is proposed to reduce the risks associated with spinal fusion. The variable stiffness is conferred to the rod using the Joule-heating local annealing technique. The annealing temperature and the mechanical properties’ distributions resulted from this thermal treatment are numerically modeled and experimentally measured. To illustrate the possible applications of such a modeling approach, two case studies are presented: (a) optimization of the Joule-heating strategy to reduce annealing time, and (b) modulation of the rod's overall flexural sti...
Source: Medical Engineering and Physics - August 12, 2014 Category: Biomedical Engineering Authors: Yann Facchinello, Vladimir Brailovski, Yvan Petit, Jean-Marc Mac-Thiong Source Type: research

Cryopreservation of Hepatocyte (HepG2) Cell Monolayers: Impact of Trehalose.
Abstract A simple method to cryogenically preserve hepatocyte monolayers is currently not available but such a technique would facilitate numerous applications in the field of biomedical engineering, cell line development, and drug screening. We investigated the effect of trehalose and dimethyl sulfoxide (Me2SO) in cryopreservation of human hepatocellular carcinoma (HepG2) cells in suspension and monolayer formats. HepG2 cell monolayers were incubated for 24 h at varying concentrations of trehalose (50-150 mM) prior to cryopreservation to identify the optimum concentration for such preincubation. When trehalose alo...
Source: Cryobiology - August 12, 2014 Category: Biology Authors: Stokich B, Osgood Q, Grimm D, Moorthy S, Chakraborty N, Menze MA Tags: Cryobiology Source Type: research

Microfluidic geometric metering-based multi-reagent mixture generator for robust live cell screening array.
Abstract Microfluidic live cell arrays with integrated concentration gradient or mixture generators have been utilized in screening cellular responses to various biomolecular cues. Microfluidic network-based gradient generators that can create concentration gradients by repeatedly splitting and mixing different solutions using networks of serpentine channels are commonly used. However, in this method the generation of concentration gradients relies on the continuous flow of sample solutions at optimized flow rates, which poses challenges in maintaining the pressure and flow stability throughout the entire assay per...
Source: Biomedical Microdevices - August 12, 2014 Category: Biomedical Engineering Authors: Wang H, Kim J, Jayaraman A, Han A Tags: Biomed Microdevices Source Type: research

Fast and Accurate Pressure-Drop Prediction in Straightened Atherosclerotic Coronary Arteries.
In this study we propose a method for computing the pressure-drop in regions proximal and distal to a plaque, which can serve as a boundary condition in CFD. As a first step towards exploring the proposed method we investigated ten straightened coronary arteries. First, the flow fields were calculated with CFD and velocity profiles were fitted on the results. Second, the Navier-Stokes equation was simplified and solved with the found velocity profiles to obtain a pressure-drop estimate (Δp (1)). Next, Δp (1) was compared to the pressure-drop from CFD (Δp CFD) as a validation step. Finally, the velocity profiles, and thu...
Source: Annals of Biomedical Engineering - August 12, 2014 Category: Biomedical Engineering Authors: Schrauwen JT, Koeze DJ, Wentzel JJ, van de Vosse FN, van der Steen AF, Gijsen FJ Tags: Ann Biomed Eng Source Type: research

A Low Computational Cost Algorithm for REM Sleep Detection Using Single Channel EEG.
Abstract The push towards low-power and wearable sleep systems requires using minimum number of recording channels to enhance battery life, keep processing load small and be more comfortable for the user. Since most sleep stages can be identified using EEG traces, enormous power savings could be achieved by using a single channel of EEG. However, detection of REM sleep from one channel EEG is challenging due to its electroencephalographic similarities with N1 and Wake stages. In this paper we investigate a novel feature in sleep EEG that demonstrates high discriminatory ability for detecting REM phases. We then use...
Source: Annals of Biomedical Engineering - August 12, 2014 Category: Biomedical Engineering Authors: Imtiaz SA, Rodriguez-Villegas E Tags: Ann Biomed Eng Source Type: research

Professor Qi Wang wins EMBS Early Career Achievement Award
(Columbia University School of Engineering and Applied Science) Qi Wang, assistant professor of biomedical engineering, recently won the prestigious 2014 Early Career Achievement Award from the IEEE Engineering in Medicine and Biology Society. EMBS, the world's largest society of biomedical engineers, cited his 'contribution to neural engineering and biomedical instrumentation, including measuring biomechanical properties of skin and tissue, building a tactile display for a virtual Braille system, and discovery of a neural basis for sensory adaptation in behavior.' (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 11, 2014 Category: Global & Universal Source Type: news

Characterization of robotic system passive path repeatability during specimen removal and reinstallation for knee joint testing
Robotic testing systems are commonly utilized for the study of orthopaedic biomechanics. Quantification of system error is essential for reliable use of robotic systems. Therefore, the purpose of this study was to quantify a 6-DOF robotic system's repeatability during knee biomechanical testing and characterize the error induced in passive path repeatability by removing and reinstalling the knee. We hypothesized removing and reinstalling the knee would substantially alter passive path repeatability. (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - August 11, 2014 Category: Biomedical Engineering Authors: Mary T. Goldsmith, Sean D. Smith, Kyle S. Jansson, Robert F. LaPrade, Coen A. Wijdicks Source Type: research

Special issue on transitions and learning
Learning, Culture and Social Interaction, Volume 3, Issue 3, pages 185-236 (Sep-14) Edited by Mariane Hedegaard, Anne Edwards (Source: Elsevier Updates: Engineering)
Source: Elsevier Updates: Engineering - August 9, 2014 Category: Biomedical Engineering Source Type: news

Four lateral mass screw fixation techniques in lower cervical spine following laminectomy: a finite element analysis study of stress distribution
Conclusion: The LSF techniques of Magerl and Roy-Camille are safer methods for stabilizing the lower cervical spine. Therefore, these methods potentially have a lower risk of fixation fracture. (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - August 9, 2014 Category: Biomedical Engineering Authors: Mingzhi SongZhen ZhangMing LuJunwei ZongChao DongKai MaShouyu Wang Source Type: research

Frequency difference beyond behavioral limen reflected by frequency following response of human auditory Brainstem
Conclusions: These results suggest that when a frequency difference cannot be behaviorally distinguished, there is still a possibility of it being detected physiologically. (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - August 9, 2014 Category: Biomedical Engineering Authors: Qin XuQin Gong Source Type: research

A miniature quantitative PCR device for directly monitoring a sample processing on a microfluidic rapid DNA system.
We report a microfluidic device and measurement method to perform real-time PCR (or qPCR) in a miniaturized configuration for on-chip implementation using reaction volumes of less than 20 μL. The qPCR bioreactor is designed as a module to be embedded in an automated sample-in/profile-out system for rapid DNA biometrics or human identification. The PCR mixture is excited with a 505 nm diode-pumped solid-state laser (DPSSL) and the fluorescence build-up is measured using optical fibers directly embedded to the sidewalls of the microfluidic qPCR bioreactor. We discuss manufacturing and operating parameters necessary to adj...
Source: Biomedical Microdevices - August 9, 2014 Category: Biomedical Engineering Authors: Hurth C, Yang J, Barrett M, Brooks C, Nordquist A, Smith S, Zenhausern F Tags: Biomed Microdevices Source Type: research

Accelerated start-up of moving bed biofilm reactor by using a novel suspended carrier with porous surface.
Abstract A novel suspended carrier with porous surface was firstly prepared by coating a sponge on the inside and outside of a hard polyethylene ring. Herein the effects of the sponge thickness (0, 2, 4, 6 mm) and pore size (17, 45, 85 pores per inch, ppi) on the performance of the start-up stage in moving bed biofilm reactor (MBBR) were investigated. The results indicated that the home-made carrier with the sponge thickness of 4 mm and the pore size of 45 ppi, defined as SC4-45, showed the best performance, which obtained high biomass concentration of 2,136.6 mg/L, oxygen uptake rate for COD of 150.1 mg O2/h...
Source: Bioprocess and Biosystems Engineering - August 9, 2014 Category: Biomedical Engineering Authors: Chen X, Kong L, Wang X, Tian S, Xiong Y Tags: Bioprocess Biosyst Eng Source Type: research

High cell density culture with S. cerevisiae CEN.PK113-5D for IL-1β production: optimization, modeling, and physiological aspects.
Abstract Saccharomyces cerevisiae CEN.PK113-5D, a strain auxotrophic for uracil belonging to the CEN.PK family of the yeast S. cerevisiae, was cultured in aerated fed-batch reactor as such and once transformed to express human interleukin-1β (IL-1β), aiming at obtaining high cell densities and optimizing IL-1β production. Three different exponentially increasing glucose feeding profiles were tested, all of them "in theory" promoting respiratory metabolism to obtain high biomass/product yield. A non-structured non-segregated model was developed to describe the performance of S. cerevisiae CEN.PK113-5D during the ...
Source: Bioprocess and Biosystems Engineering - August 9, 2014 Category: Biomedical Engineering Authors: Landi C, Paciello L, de Alteriis E, Brambilla L, Parascandola P Tags: Bioprocess Biosyst Eng Source Type: research

Nonparametric Spectral Estimation of Phase Noise in Modulated Signals Based on Complementary Autocorrelation
A novel nonparametric spectral estimation technique for phase noise based on the complementary autocorrelation (CAC) is presented. Utilizing the fact that the CAC of phase noise is not zero, this technique offers a distinct advantage that the power spectrum of phase noise is estimated whereas that of other kinds of noise are suppressed as long as they are proper (second-order circularity). This property is most useful when estimating the phase noise spectrum directly from digitally-modulated signals because those signals are typically accompanied by various kinds of undesired noise that easily mask the phase noise of inter...
Source: IEEE Transactions on Signal Processing - August 8, 2014 Category: Biomedical Engineering Source Type: research

Single-Carrier Frequency Domain Equalization for Hammerstein Communication Systems Using Complex-Valued Neural Networks
Single-carrier (SC) block transmission with frequency-domain equalization (FDE) offers a viable transmission technology for combating the adverse effects of long dispersive channels encountered in high-rate broadband wireless communication systems. However, for high-bandwidth efficiency and high-power-efficiency systems, the channel can generally be modeled by the Hammerstein system, which includes the nonlinear distortion effects of the high-power amplifier (HPA) at transmitter. For such nonlinear Hammerstein channels, the standard SC-FDE scheme no longer works. This paper advocates a complex-valued (CV) B-spline neural-n...
Source: IEEE Transactions on Signal Processing - August 8, 2014 Category: Biomedical Engineering Source Type: research

Optimized Markov Chain Monte Carlo for Signal Detection in MIMO Systems: An Analysis of the Stationary Distribution and Mixing Time
We introduce an optimized Markov chain Monte Carlo (MCMC) technique for solving integer least-squares (ILS) problems, which include maximum likelihood (ML) detection in multiple-input multiple-output (MIMO) systems. Two factors contribute to its speed of finding the optimal solution: the probability of encountering the optimal solution when the Markov chain has converged to the stationary distribution, and the mixing time of the MCMC detector. First, we compute the optimal “temperature” parameter value, so that once the Markov chain has mixed to its stationary distribution, there is a polynomially small proba...
Source: IEEE Transactions on Signal Processing - August 8, 2014 Category: Biomedical Engineering Source Type: research

Transmit Designs for the MIMO Broadcast Channel With Statistical CSI
We investigate the multiple-input multiple-output broadcast channel with statistical channel state information available at the transmitter. The so-called linear assignment operation is employed, and necessary conditions are derived for the optimal transmit design under general fading conditions. Based on this, we introduce an iterative algorithm to maximize the linear assignment weighted sum-rate by applying a gradient descent method. To reduce complexity, we derive an upper bound of the linear assignment achievable rate of each receiver, from which a simplified closed-form expression for a near-optimal linear assignment ...
Source: IEEE Transactions on Signal Processing - August 8, 2014 Category: Biomedical Engineering Source Type: research

Iterative Learning for Reference-Guided DNA Sequence Assembly From Short Reads: Algorithms and Limits of Performance
Recent emergence of next-generation DNA sequencing technology has enabled acquisition of genetic information at unprecedented scales. In order to determine the genetic blueprint of an organism, sequencing platforms typically employ the shotgun sequencing strategy to oversample the target genome with a library of relatively short overlapping reads. The order of nucleotides in the reads is determined by processing the acquired noisy signals generated by the sequencing instrument. Assembly of a genome from potentially erroneous short reads is a computationally daunting task even when a reference genome exists. Errors and gaps...
Source: IEEE Transactions on Signal Processing - August 8, 2014 Category: Biomedical Engineering Source Type: research

Independent Vector Analysis: Identification Conditions and Performance Bounds
Recently, an extension of independent component analysis (ICA) from one to multiple datasets, termed independent vector analysis (IVA), has been a subject of significant research interest. IVA has also been shown to be a generalization of Hotelling's canonical correlation analysis. In this paper, we provide the identification conditions for a general IVA formulation, which accounts for linear, nonlinear, and sample-to-sample dependencies. The identification conditions are a generalization of previous results for ICA and for IVA when samples are independently and identically distributed. Furthermore, a principal aim of IVA ...
Source: IEEE Transactions on Signal Processing - August 8, 2014 Category: Biomedical Engineering Source Type: research

A Novel Family of Adaptive Filtering Algorithms Based on the Logarithmic Cost
We introduce a novel family of adaptive filtering algorithms based on a relative logarithmic cost inspired by the “competitive methods” from the online learning literature. The competitive or regret based approaches stabilize or improve the convergence performance of adaptive algorithms through relative cost functions. The new family elegantly and gradually adjusts the conventional cost functions in its optimization based on the error amount. We introduce important members of this family of algorithms such as the least mean logarithmic square (LMLS) and least logarithmic absolute difference (LLAD) algorithms....
Source: IEEE Transactions on Signal Processing - August 8, 2014 Category: Biomedical Engineering Source Type: research

A Peak Synchronization Measure for Multiple Signals
Peaks signify important events in a signal. In a pair of signals how peaks are occurring with mutual correspondence may offer us significant insights into the mutual interdependence between the two signals based on important events. In this work we proposed a novel synchronization measure between two signals, called peak synchronization, which measures the simultaneity of occurrence of peaks in the signals. We subsequently generalized it to more than two signals. We showed that our measure of synchronization is largely independent of the underlying parameter values. A time complexity analysis of the algorithm has also been...
Source: IEEE Transactions on Signal Processing - August 8, 2014 Category: Biomedical Engineering Source Type: research

Joint Local Quantization and Linear Cooperation in Spectrum Sensing for Cognitive Radio Networks
In designing cognitive radio networks (CRNs), protecting the license holders from harmful interference while maintaining acceptable quality-of-service (QoS) levels for the secondary users is a challenge effectively mitigated by cooperative spectrum sensing schemes. In this paper, cooperative spectrum sensing in CRNs is studied as a three-phase process composed of local sensing, reporting, and decision/data fusion. Then, a significant tradeoff in designing the reporting phase, i.e., the effect of the number of bits used in local sensing quantization on the overall sensing performance, is identified and formulated. In additi...
Source: IEEE Transactions on Signal Processing - August 8, 2014 Category: Biomedical Engineering Source Type: research

Hierarchical Infinite Divisibility for Multiscale Shrinkage
A new shrinkage-based construction is developed for a compressible vector ${mmb x}inBBR^{n}$, for cases in which the components of ${mmb x}$ are naturally associated with a tree structure. Important examples are when ${mmb x}$ corresponds to the coefficients of a wavelet or block-DCT representation of data. The method we consider in detail, and for which numerical results are presented, is based on the gamma distribution. The gamma distribution is a heavy-tailed distribution that is infinitely divisible, and these characteristics are leveraged within the model. We further demonstrate that the general framework is appropria...
Source: IEEE Transactions on Signal Processing - August 8, 2014 Category: Biomedical Engineering Source Type: research

Parameter Estimation of 2D Multi-Component Polynomial Phase Signals: An Application to SAR Imaging of Moving Targets
Polynomial-phase signals (PPS) appear in a variety of applications and several algorithms are available to estimate their parameters in the presence of noise. Among the available tools, the product high order ambiguity function (PHAF) has the merit of performing well in the presence of a superposition of PPS's. In this work, we generalize the PHAF to handle two-dimensional PPS's. Then we show an example of application motivating such an extension: the high resolution imaging of moving targets from synthetic aperture radars (SAR). Using the 2D-PHAF, we will propose an algorithm that compensates jointly for the range cell mi...
Source: IEEE Transactions on Signal Processing - August 8, 2014 Category: Biomedical Engineering Source Type: research

Calibration and segmentation of skin areas in hyperspectral imaging for the needs of dermatology
Conclusions: The obtained results confirm the usefulness of the applied method for image analysis and processing in dermatological practice. In particular, it is useful in the quantitative evaluation of skin lesions. Such analysis can be performed fully automatically without operator's intervention. (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - August 8, 2014 Category: Biomedical Engineering Authors: Robert KoprowskiSlawomir Wilczy¿skiZygmunt WróbelBarbara B¿o¿ska-Fajfrowska Source Type: research

Failure mode and effects analysis applied to the maintenance and repair of anesthetic equipment in an austere medical environment
Conclusions This study demonstrates the feasibility of using the failure mode and effects analysis approach to improve implementation of technology in austere medical environments. (Source: International Journal for Quality in Health Care)
Source: International Journal for Quality in Health Care - August 8, 2014 Category: Global & Universal Authors: Rosen, M. A., Lee, B. H., Sampson, J. B., Koka, R., Chima, A. M., Ogbuagu, O. U., Marx, M. K., Kamara, T. B., Koroma, M., Jackson, E. V. Tags: Papers Source Type: research

A time-frequency approach to estimate critical time intervals in postural control.
Abstract The critical time interval (CTI) is a parameter that has been used to distinguish open-loop from closed-loop control during upright stance. The aim of this study was to develop a new method to determine CTIs. The new approach, termed the intermittent critical time interval (ICTI) method, was motivated from evidence that upright standing is an intermittent rather than an asymptotic stability control process. For this ICTI method, center-of-pressure time series are first transformed to the time-frequency domain with a wavelet method. Subsequently, the CTI is assumed equal to the time span between two local m...
Source: Computer Methods in Biomechanics and Biomedical Engineering - August 8, 2014 Category: Biomedical Engineering Authors: Zhang H, Nussbaum MA, Agnew MJ Tags: Comput Methods Biomech Biomed Engin Source Type: research

Acoustic Estimation of Neck Fluid Volume.
In this study, we developed a novel approach for non-invasive estimation of NFV from acoustic measurements. Twenty-eight healthy subjects lay awake and supine for 90 min while NFV and tracheal sounds were measured simultaneously using bioimpedance and a microphone, respectively. Sets of tracheal sound features were calculated in time and frequency domains and were reduced using methods based on regression and minimum-redundancy-maximum-relevance. The resulting feature sets were applied to a multi-linear regression and a mixture-density neural network to estimate NFV. Our results show very small relative estimation errors ...
Source: Annals of Biomedical Engineering - August 8, 2014 Category: Biomedical Engineering Authors: Yadollahi A, Rudzicz F, Mahallati S, Coimbra M, Bradley TD Tags: Ann Biomed Eng Source Type: research

Pregnancy-Induced Remodeling of Collagen Architecture and Content in the Mitral Valve.
This study has shown that the mitral valve is strongly adaptive during pregnancy, with significant changes in size, collagen content and architecture in response to rapidly changing demands. PMID: 25103603 [PubMed - as supplied by publisher] (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - August 8, 2014 Category: Biomedical Engineering Authors: Pierlot CM, Lee JM, Amini R, Sacks MS, Wells SM Tags: Ann Biomed Eng Source Type: research

Fabrication of carbon nanotube-polyimide composite hollow microneedles for transdermal drug delivery.
Abstract We introduce a novel method for fabricating hollow microneedles for transdermal drug delivery using a composite of vertically-aligned carbon nanotubes and polyimide. Patterned bundles of carbon nanotubes are used as a porous scaffold for defining the microneedle geometry. Polyimide resin is wicked through the carbon nanotube scaffold to reinforce the structure and provide the prerequisite strength for achieving skin penetration. The high aspect ratio and bottom-up assembly of carbon nanotubes allow the structure of the microneedles to be created in a single step of nanotube fabrication, providing a simple,...
Source: Biomedical Microdevices - August 7, 2014 Category: Biomedical Engineering Authors: Lyon BJ, Aria AI, Gharib M Tags: Biomed Microdevices Source Type: research

Enhanced global mathematical model for studying cerebral venous blood flow
Here we extend the global, closed-loop, mathematical model for the cardiovascular system in: Müller, L.O and Toro, E.F. A global multiscale mathematical model for the human circulation with emphasis on the venous system. International Journal for Numerical Methods in Biomedical Engineering, 30:681–725, 2014,, to account for fundamental mechanisms affecting cerebral venous haemodynamics: the interaction between intracranial pressure and cerebral vasculature and the Starling-resistor like behaviour of intracranial veins. (Source: Journal of Biomechanics)
Source: Journal of Biomechanics - August 7, 2014 Category: Biomedical Science Authors: Lucas O. Müller, Eleuterio F. Toro Source Type: research

Production of alkyl esters from macaw palm oil by a sequential hydrolysis/esterification process using heterogeneous biocatalysts: optimization by response surface methodology.
Abstract The present study deals with the enzymatic synthesis of alkyl esters with emollient properties by a sequential hydrolysis/esterification process (hydroesterification) using unrefined macaw palm oil from pulp seeds (MPPO) as feedstock. Crude enzymatic extract from dormant castor bean seeds was used as biocatalyst in the production of free fatty acids (FFA) by hydrolysis of MPPO. Esterification of purified FFA with several alcohols in heptane medium was catalyzed by immobilized Thermomyces lanuginosus lipase (TLL) on poly-hydroxybutyrate (PHB) particles. Under optimal experimental conditions (mass ratio oil:...
Source: Bioprocess and Biosystems Engineering - August 7, 2014 Category: Biomedical Engineering Authors: Bressani AP, Garcia KC, Hirata DB, Mendes AA Tags: Bioprocess Biosyst Eng Source Type: research

Asymmetric Cell-Matrix and Biomechanical Abnormalities in Elastin Insufficiency Induced Aortopathy.
Abstract Aortopathy is characterized by vascular smooth muscle cell (VSMC) abnormalities and elastic fiber fragmentation. Elastin insufficient (Eln (+/-) ) mice demonstrate latent aortopathy similar to human disease. We hypothesized that aortopathy manifests primarily in the aorto-pulmonary septal (APS) side of the thoracic aorta due to asymmetric cardiac neural crest (CNC) distribution. Anatomic (aortic root vs. ascending aorta) and molecular (APS vs. non-APS) regions of proximal aorta tissue were examined in adult and aged wild type (WT) and mutant (Eln (+/-) ) mice. CNC, VSMCs, elastic fiber architecture, proteo...
Source: Annals of Biomedical Engineering - August 7, 2014 Category: Biomedical Engineering Authors: Krishnamurthy VK, Evans AN, Wansapura JP, Osinska H, Maddy KE, Biechler SV, Narmoneva DA, Goodwin RL, Hinton RB Tags: Ann Biomed Eng Source Type: research

Finite element analysis of three commonly used external fixation devices for treating Type III pilon fractures
Pilon fractures are commonly caused by high energy trauma and can result in long-term immobilization of patients. The use of an external fixator i.e. the (1) Delta, (2) Mitkovic or (3) Unilateral frame for treating type III pilon fractures is generally recommended by many experts owing to the stability provided by these constructs. This allows this type of fracture to heal quickly whilst permitting early mobilization. However, the stability of one fixator over the other has not been previously demonstrated. (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - August 7, 2014 Category: Biomedical Engineering Authors: Muhammad Hanif Ramlee, Mohammed Rafiq Abdul Kadir, Malliga Raman Murali, Tunku Kamarul Source Type: research

Low-Intensity Pulsed Ultrasound Activates Integrin-Mediated Mechanotransduction Pathway in Synovial Cells.
In conclusion, LIPUS exposure might be involved in cell apoptosis and survival of synovial membrane cells via integrin/FAK/MAPK pathway. PMID: 25096496 [PubMed - as supplied by publisher] (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - August 6, 2014 Category: Biomedical Engineering Authors: Sato M, Nagata K, Kuroda S, Horiuchi S, Nakamura T, Karima M, Inubushi T, Tanaka E Tags: Ann Biomed Eng Source Type: research