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Biomedical Engineering

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 13.

Learning Methods for CDF Scheduling in Multiuser Heterogeneous Systems
In modern heterogeneous wireless networks, the task of supporting fairness along with user priorities and concurrently achieving the highest possible system throughput is desirable and challenging. In this work, two classes of practical cumulative distribution function (CDF) based scheduling algorithms are developed to achieve these goals. These algorithms are shown to frequently outperform, and are potential alternatives to, the well known Proportional Fair (PF) scheduling method. The first class of algorithms, Nonparametric CDF based scheduling (NPCS) algorithms, are used when the channel fading model is unknown. Herein,...
Source: IEEE Transactions on Signal Processing - July 11, 2014 Category: Biomedical Engineering Source Type: research

Performance Assessment of a Brain-Computer Interface Driven Hand Orthosis.
Abstract Stroke survivors are typically affected by hand motor impairment. Despite intensive rehabilitation and spontaneous recovery, improvements typically plateau a year after a stroke. Therefore, novel approaches capable of restoring or augmenting lost motor behaviors are needed. Brain-computer interfaces (BCIs) may offer one such approach by using neurophysiological activity underlying hand movements to control an upper extremity orthosis. To test the performance of such a system, we developed an electroencephalogram-based BCI controlled electrically actuated hand orthosis. Six able-bodied participants voluntar...
Source: Annals of Biomedical Engineering - July 11, 2014 Category: Biomedical Engineering Authors: King CE, Dave KR, Wang PT, Mizuta M, Reinkensmeyer DJ, Do AH, Moromugi S, Nenadic Z Tags: Ann Biomed Eng Source Type: research

Magnetic Droplet Manipulation Platforms for Nucleic Acid Detection at the Point of Care.
Abstract This review summarizes recent developments in the use of magnetically actuated droplets in point-of-care molecular diagnostic platforms. We discuss the fundamentals of magnetic droplet manipulation and the various modes of actuation. The balance of forces acting on a droplet during transport and particle extraction, as well as the devices and instrumentation developed to perform these operations will be presented and discussed. Furthermore, we review some of the recent advances on the diagnostic applications of platforms utilizing magnetic manipulation for genetic assessment of biological samples. PMID...
Source: Annals of Biomedical Engineering - July 10, 2014 Category: Biomedical Engineering Authors: Shin DJ, Wang TH Tags: Ann Biomed Eng Source Type: research

Join Us for a Conversation Between TIME and the Space Station
Everything about the International Space Station (ISS) is built to wow. It’s almost exactly the size of a football field, has as much habitable space as a six-bedroom house, orbits 230 miles overhead, required 115 space flights to build and carries a solar panel array with a surface area of one acre. The offices of TIME magazine—located on the slightly less glamorous Avenue of the Americas and 51st St. in New York City, and with about as much habitable space as, um, an office— can hardly compete. But on July 9, the two worlds will briefly collide, as TIME chats via video downlink with the ISS. There are currently...
Source: TIME.com: Top Science and Health Stories - July 8, 2014 Category: Consumer Health News Authors: Jeffrey Kluger Tags: Uncategorized Gerst NASA russia space Space Exploration space station Swanson TIME Wiseman Source Type: news

Validation of the pulse decomposition analysis algorithm using central arterial blood pressure
Conclusions: The results indicate that arterial blood pressure can be accurately measured and tracked noninvasively and continuously using the CareTaker system and the PDA algorithm. The results further support the physical model that all of the features of the pressure pulse envelope, whether in the central arteries or in the arterial periphery, can be explained by the interaction of the left ventricular ejection pressure pulse with two centrally located reflection sites. (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - July 8, 2014 Category: Biomedical Engineering Authors: Martin BaruchKambiz KalantariDavid GerdtCharles Adkins Source Type: research

An in-situ calibration method and the effects on stimulus frequency otoacoustic emissions
Conclusions: This study suggests that calibration methods currently used in the clinic may produce unreliable results. The in-situ calibration based on the estimated TM SPL could avoid the standing-wave problem and might be incorporated into clinical OAE measurements for more accurate hearing loss screenings. (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - July 8, 2014 Category: Biomedical Engineering Authors: Shixiong ChenHaoshi ZhangLan WangGuanglin Li Source Type: research

Heterogeneous integration of gels into microfluidics using a mesh carrier.
Abstract The incorporation of hydrogels inside microfluidics is a promising method for localizing receptors inside microfluidic structures for many bio-analytical applications as well as for working with cells. However, current methods rely on the in situ polymerization of hydrogels and therefore necessitate optical masks and extensive post-polymerization steps for example for washing uncrosslinked gel precursors and receptors. Here, we report a simple and efficient method for the integration of hydrogels to microfluidic chips. Small volumes of poly(ethylene)glycol-based acrylamide (PEGACA) hydrogels are photopolym...
Source: Biomedical Microdevices - July 8, 2014 Category: Biomedical Engineering Authors: Eker B, Temiz Y, Delamarche E Tags: Biomed Microdevices Source Type: research

Feasibility of hydraulic separation in a novel anaerobic-anoxic upflow reactor for biological nutrient removal.
Abstract This contribution deals with a novel anaerobic-anoxic reactor for biological nutrient removal (BNR) from wastewater, termed AnoxAn. In the AnoxAn reactor, the anaerobic and anoxic zones for phosphate removal and denitrification are integrated in a single continuous upflow sludge blanket reactor, aiming at high compactness and efficiency. Its application is envisaged in those cases where retrofitting of existing wastewater treatment plants for BNR, or the construction of new ones, is limited by the available surface area. The environmental conditions are vertically divided up inside the reactor with the ana...
Source: Bioprocess and Biosystems Engineering - July 8, 2014 Category: Biomedical Engineering Authors: Díez-Montero R, De Florio L, González-Viar M, Volcke EI, Tejero I Tags: Bioprocess Biosyst Eng Source Type: research

Fast computation of voxel-level brain connectivity maps from resting-state functional MRI using l-norm as approximation of Pearson's temporal correlation: Proof-of-concept and example vector hardware implementation
An outstanding issue in graph-based analysis of resting-state functional MRI is choice of network nodes. Individual consideration of entire brain voxels may represent a less biased approach than parcellating the cortex according to pre-determined atlases, but entails establishing connectedness for 19–111 links, with often prohibitive computational cost. Using a representative Human Connectome Project dataset, we show that, following appropriate time-series normalization, it may be possible to accelerate connectivity determination replacing Pearson correlation with l1-norm. (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - July 8, 2014 Category: Biomedical Engineering Authors: Ludovico Minati, Domenico Zacà, Ludovico D’Incerti, Jorge Jovicich Source Type: research

A tissue stabilization device for MRI-guided breast biopsy
We present a breast tissue stabilization device that can be used in magnetic resonance imaging-guided biopsy. The device employs adjustable support plates with an optimized geometry to minimize the biopsy target displacement using smaller compression than the conventional parallel plates approach. It is expected that the reduced compression will cause less patient discomfort and improve image quality by enhancing the contrast intake. Precomputed optimal positions of the stabilization plates for a given biopsy target location are provided in a look-up table. (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - July 8, 2014 Category: Biomedical Engineering Authors: Alexandru Patriciu, Maggie Chen, Behzad Iranpanah, Shahin Sirouspour Source Type: research

Editorial Board
(Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - July 7, 2014 Category: Biomedical Engineering Source Type: research

An MRI compatible loading device for the reconstruction of clinically relevant plantar pressure distributions and loading scenarios of the forefoot
The purpose of this study is to demonstrate a new MRI compatible loading device capable of reconstructing realistic loading scenarios of the human foot for research in the field of foot biomechanics. This device has two different configurations: one used to compress the forefoot and one to bend the metatarsophalangeal joints. Required plantar pressure distribution under the metatarsal heads can be achieved by modifying the distribution of the dorsally applied forces. To validate the device, subject-specific plantar pressures were measured and then reconstructed using the device. (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - July 7, 2014 Category: Biomedical Engineering Authors: Panagiotis E. Chatzistergos, Roozbeh Naemi, Nachiappan Chockalingam Source Type: research

Production of manganese peroxidase and laccase in a solid-state bioreactor and modeling of enzyme production kinetics.
In this study, the production of laccase and manganese peroxidase (MnP) in solid-state cultivation was examined. Oat husks were used as an inexpensive substrate for the white-rot fungus Cerrena unicolor PM170798 (FBCC 387). The addition of a fines fraction (consisting of oat flour and finely ground husks) enhanced MnP production fivefold and laccase production almost threefold. The enzyme production was studied first on a 100 g scale, and the cultivation experiments were then repeated at a larger laboratory-scale (4 kg) in a solid-state bioreactor. High enzyme activity levels were obtained (MnP: 340 nkat g(-1) DM, lac...
Source: Bioprocess and Biosystems Engineering - July 6, 2014 Category: Biomedical Engineering Authors: Moilanen U, Winquist E, Mattila T, Hatakka A, Eerikäinen T Tags: Bioprocess Biosyst Eng Source Type: research

Machine learning, medical diagnosis, and biomedical engineering research - commentary
A large number of papers are appearing in the biomedical engineering literature that describe the use of machine learning techniques to develop classifiers for detection or diagnosis of disease. However, the usefulness of this approach in developing clinically validated diagnostic techniques so far has been limited and the methods are prone to overfitting and other problems which may not be immediately apparent to the investigators. This commentary is intended to help sensitize investigators as well as readers and reviewers of papers to some potential pitfalls in the development of classifiers, and suggests steps that rese...
Source: BioMed Central - July 5, 2014 Category: Journals (General) Authors: Kenneth R FosterRobert KoprowskiJoseph D Skufca Source Type: research

Adsorption of Ag (I) from aqueous solution by waste yeast: kinetic, equilibrium and mechanism studies.
Abstract One type of biosorbents, brewer fermentation industry waste yeast, was developed to adsorb the Ag (I) in aqueous solution. The result of FTIR analysis of waste yeast indicated that the ion exchange, chelating and reduction were the main binding mechanisms between the silver ions and the binding sites on the surface of the biomass. Furthermore, TEM, XRD and XPS results suggested that Ag(0) nanoparticles were deposited on the surface of yeast. The kinetic experiments revealed that sorption equilibrium could reach within 60 min, and the removal efficiency of Ag (I) could be still over 93 % when the initial ...
Source: Bioprocess and Biosystems Engineering - July 5, 2014 Category: Biomedical Engineering Authors: Zhao Y, Wang D, Xie H, Won SW, Cui L, Wu G Tags: Bioprocess Biosyst Eng Source Type: research

On the Accuracy and Resolvability of Vector Parameter Estimates
In this paper we address the problem of fundamental limitations on resolution in deterministic parameters estimation. We introduce a definition of resolvability based on probability and incorporating a requirement for accuracy unlike most existing definitions. Indeed in many application the key problem is to obtain distributions of estimates that are not only distinguishable but also accurate and compliant with a required precision. We exemplify the proposed definition with estimators that produce normal estimates, as in the conditional model for which the Gaussianity and efficiency of maximum likelihood estimators (MLEs) ...
Source: IEEE Transactions on Signal Processing - July 4, 2014 Category: Biomedical Engineering Source Type: research

Sparse CT reconstruction based on multi-direction anisotropic total variation (MDATV)
Conclusions: MDATV regularization can sufficiently use the prior information of image sparsity and edge information simultaneously. By incorporating more prior information, MDATV based approach could reconstruct the image more exactly. (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - July 4, 2014 Category: Biomedical Engineering Authors: Hongxiao LiXiaodong ChenYi WangZhongxing ZhouQingzhen ZhuDaoyin Yu Source Type: research

Why You Should Become a Biomedical Engineer
Interested in becoming a biomedical engineer? If you enjoy biology, engineering, and medicine, a career as a biomedical engineer may be for you. (Source: About.com Health Careers)
Source: About.com Health Careers - July 4, 2014 Category: Universities & Medical Training Authors: healthcareers.guide at about.com Tags: careers Source Type: news

Quantitative assessment of the impact of biomedical image acquisition on the results obtained from image analysis and processing
Conclusions: The paper presents vital, selected issues occurring when assessing the accuracy of designed automatic algorithms for image analysis and processing in bioengineering. The impact of acquisition of images on the problems arising in their analysis has been shown on selected examples. It has also been indicated to which elements of image analysis and processing special attention should be paid in their design. (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - July 4, 2014 Category: Biomedical Engineering Authors: Robert Koprowski Source Type: research

Assessment of telemetry and fluidic control system used in the Medstream programmable infusion system: an in vivo and in vitro study.
Abstract The MedStream Programmable Infusion Pump, an intrathecal pump indicated for the treatment of chronic intractable pain and severe spasticity (CE-mark) or severe spasticity (US), has a highly accurate medication delivery (within 10 % of the programmed flow rate) and is certified for use in 3-Tesla magnetic resonance imaging systems (conditional). Performance of the telemetric link between external control-unit and implanted pump was assessed in sheep (in vivo) up to 26 weeks, resulting in 1040 communication sessions. The telemetric communication envelope (communication distance and maximum antenna tilt ang...
Source: Biomedical Microdevices - July 4, 2014 Category: Biomedical Engineering Authors: Bork T, Crivelli R, Tardy Y, Burger J Tags: Biomed Microdevices Source Type: research

Modeling and steady state simulation: production of xanthan gum from sugarcane broth.
Abstract The work is focused on developing a mathematical model for continuous process of xanthan gum production. The main objective of the study is to simulate the model, observe the behavior of substrate consumption, biomass and product formation with respect to dilution rate and determine the optimum dilution rate for which the reactor is to be designed. Systems with and without recycling of cells are considered and the optimum dilution rate is found. For the kinetic parameters used, the optimum dilution rate for the system with no recycling is 0.205 and 0.35 h(-1) for the system that includes recycling of cell...
Source: Bioprocess and Biosystems Engineering - July 4, 2014 Category: Biomedical Engineering Authors: Vignesh P, Arumugam A, Ponnusami V Tags: Bioprocess Biosyst Eng Source Type: research

Benchmarking of dynamic simulation predictions in two software platforms using an upper limb musculoskeletal model.
We present a new upper limb dynamic model as a tool to evaluate potential differences in predictive behavior between platforms. We evaluated to what extent differences in technical implementations in popular simulation software environments result in differences in kinematic predictions for single and multijoint movements using EMG- and optimization-based approaches for deriving control signals. We illustrate the benchmarking comparison using SIMM-Dynamics Pipeline-SD/Fast and OpenSim platforms. The most substantial divergence results from differences in muscle model and actuator paths. This model is a valuable resource an...
Source: Computer Methods in Biomechanics and Biomedical Engineering - July 4, 2014 Category: Biomedical Engineering Authors: Saul KR, Hu X, Goehler CM, Vidt ME, Daly M, Velisar A, Murray WM Tags: Comput Methods Biomech Biomed Engin Source Type: research

Ultrabright organic dots with aggregation-induced emission characteristics for cell tracking.
Abstract Noninvasive fluorescence cell tracking provides critical information on the physiological displacement and translocation of actively migrating cells, which deepens our understanding of biomedical engineering, oncological research, stem cell transplantation and therapies. Non-viral fluorescent protein transfection based cell tracing has been widely used but with issues related to cell type-dependent expression, lagged readout, immunogenicity and mutagenesis. Alternative cell tracking methods are therefore desired to attain reliable, stable, and efficient labeling over a long time. In this work, we have succ...
Source: Biomaterials - July 4, 2014 Category: Materials Science Authors: Feng G, Tay CY, Chui QX, Liu R, Tomczak N, Liu J, Tang BZ, Leong DT, Liu B Tags: Biomaterials Source Type: research

Inter-scanner differences in QCT measurements of the density and strength of the proximal femur remain after correction with anthropomorphic standardization phantoms
In this study, in vivo imaging of 20 women on two imaging systems was used to evaluate inter-scanner differences in hip integral BMD (iBMD), trabecular BMD (tBMD), cortical BMD (cBMD), femoral neck yield moment (My) and yield force (Fy), and finite-element derived strength of the femur under stance (FEstance) and fall (FEfall) loading. (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - July 4, 2014 Category: Biomedical Engineering Authors: R. Dana Carpenter, Isra Saeed, Serena Bonaretti, Carole Schreck, Joyce H. Keyak, Timothy Streeper, Tamara B. Harris, Thomas F. Lang Source Type: research

Characterization of a CMOS sensing core for ultra-miniature wireless implantable temperature sensors with application to cryomedicine
In effort to improve thermal control in minimally invasive cryosurgery, the concept of a miniature, wireless, implantable sensing unit has been developed recently. The sensing unit integrates a wireless power delivery mechanism, wireless communication means, and a sensing core—the subject matter of the current study. The current study presents a CMOS ultra-miniature PTAT temperature sensing core and focuses on design principles, fabrication of a proof-of-concept, and characterization in a cryogenic environment. (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - July 4, 2014 Category: Biomedical Engineering Authors: Ahmad Khairi, Chandrajit Thaokar, Gary Fedder, Jeyanandh Paramesh, Yoed Rabin Source Type: research

Subject-specific evaluation of patellofemoral joint biomechanics during functional activity
In this study, biomechanical experiments and computational modeling were used to study patellofemoral contact mechanics in four healthy adults during stair ambulation. Subject-specific anatomical and gait data were recorded using magnetic resonance imaging, dynamic X-ray fluoroscopy, video motion capture, and multiple force platforms. (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - July 3, 2014 Category: Biomedical Engineering Authors: Massoud Akbarshahi, Justin W. Fernandez, Anthony G. Schache, Marcus G. Pandy Source Type: research

Exploiting parameter sparsity in model-based reconstruction to accelerate proton density and T mapping
T2 mapping is a powerful noninvasive technique providing quantitative biological information of the inherent tissue properties. However, its clinical usage is limited due to the relative long scanning time. This paper proposed a novel model-based method to address this problem. Typically, we directly estimated the relaxation values from undersampled k-space data by exploiting the sparse property of proton density and T2 map in a penalized maximum likelihood formulation. An alternating minimization approach was presented to estimate the relaxation maps separately. (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - July 3, 2014 Category: Biomedical Engineering Authors: Xi Peng, Xin Liu, Hairong Zheng, Dong Liang Source Type: research

Posterior cruciate ligament balancing in total knee arthroplasty: a numerical study with a dynamic force controlled knee model
Conclusions: Our study showed that dynamic FEM is an effective method for simulation of PCL balancing in knee arthroplasty. A tight PCL led in silico to more anterior tibia translation, a higher collateral ligament and inlay stress, while retropatellar pressure remained unchanged. Surgeons may take these results in vivo into account. (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - July 2, 2014 Category: Biomedical Engineering Authors: Arnd SteinbrückMatthias WoiczinskiPatrick WeberPeter MüllerVolkmar JanssonChristian Schröder Source Type: research

Effect of biofilm formation on the performance of microbial fuel cell for the treatment of palm oil mill effluent.
In this study, double-chamber microbial fuel cell was operated with diluted POME (initial COD = 1,000 mg L(-1)) and polyacrylonitrile carbon felt was used as electrode. The maximum power density, COD removal efficiency and Coulombic efficiency were found as 22 mW m(-2), 70 and 24 %, respectively. FTIR and TGA analysis confirmed the formation of biofilm on the electrode surface during MFC operation. The impact of anode biofilm on anodic polarization resistance was investigated using electrochemical impedance spectroscopy (EIS) and microbial community changes during MFC operation using denaturing gradient gel electrop...
Source: Bioprocess and Biosystems Engineering - July 2, 2014 Category: Biomedical Engineering Authors: Baranitharan E, Khan MR, Prasad DM, Teo WF, Tan GY, Jose R Tags: Bioprocess Biosyst Eng Source Type: research

An Experimental Investigation of the Effect of Mechanical and Biochemical Stimuli on Cell Migration Within a Decellularized Vascular Construct.
Abstract The goal of this study was to promote rapid repopulation of the medial layer of decellularized tissues for use as vascular grafts. We utilized a combined approach of biochemical and mechanical stimuli to enhance repopulation of decellularized porcine arterial tissue. Chitosan β-glycerophosphate loaded with hepatocyte growth factor (HGF) was injected into a channel in the artery wall while rat mesenchymal stem cells (rMSCs) were injected in two channels located 120° to this channel. In a second group rMSCs were injected into channels located at intervals of 120°. Both groups were subjected to 7 days mec...
Source: Annals of Biomedical Engineering - July 2, 2014 Category: Biomedical Engineering Authors: Sheridan WS, Ryan AJ, Duffy GP, O'Brien FJ, Murphy BP Tags: Ann Biomed Eng Source Type: research

Tortuosity of Coronary Bifurcation as a Potential Local Risk Factor for Atherosclerosis: CFD Steady State Study Based on In Vivo Dynamic CT Measurements.
This study not only demonstrated that CT imaging studies of local risk factor for atherosclerosis could be clinically performed, but also showed that tortuosity of LM-LAD coronary branch could be used as a surrogate marker for the onset of atherosclerosis. PMID: 24986333 [PubMed - as supplied by publisher] (Source: Annals of Biomedical Engineering)
Source: Annals of Biomedical Engineering - July 2, 2014 Category: Biomedical Engineering Authors: Malvè M, Gharib AM, Yazdani SK, Finet G, Martínez MA, Pettigrew R, Ohayon J Tags: Ann Biomed Eng Source Type: research

Cell reprogramming into the pluripotent state using graphene based substrates.
Abstract Graphene has been attracting considerable interest in the field of biomedical engineering because graphene and its derivatives are considered to be ideal platforms for supporting cell growth and differentiation. Here we report that graphene promotes the reprogramming of mouse somatic fibroblasts into induced pluripotent stem cells (iPSCs). We constructed a layer of graphene film on a glass substrate and characterized it as a monolayer using Raman spectroscopy. We found that the graphene substrate significantly improved cellular reprogramming efficiency by inducing mesenchymal-to-epithelial-transition (MET)...
Source: Biomaterials - July 2, 2014 Category: Materials Science Authors: Yoo J, Kim J, Baek S, Park Y, Im H, Kim J Tags: Biomaterials Source Type: research

Table of contents
(Source: IEE Transactions on Medical Imaging)
Source: IEE Transactions on Medical Imaging - July 1, 2014 Category: Biomedical Engineering Source Type: research

IEEE Transactions on Medical Imaging publication information
(Source: IEE Transactions on Medical Imaging)
Source: IEE Transactions on Medical Imaging - July 1, 2014 Category: Biomedical Engineering Source Type: research

Development and Application of a Suite of 4-D Virtual Breast Phantoms for Optimization and Evaluation of Breast Imaging Systems
Mammography is currently the most widely utilized tool for detection and diagnosis of breast cancer. However, in women with dense breast tissue, tissue overlap may obscure lesions. Digital breast tomosynthesis can reduce tissue overlap. Furthermore, imaging with contrast enhancement can provide additional functional information about lesions, such as morphology and kinetics, which in turn may improve lesion identification and characterization. The performance of these imaging techniques is strongly dependent on the structural composition of the breast, which varies significantly among patients. Therefore, imaging system an...
Source: IEE Transactions on Medical Imaging - July 1, 2014 Category: Biomedical Engineering Source Type: research

Numerical Characterization of Quasi-Static Ultrasound Elastography for the Detection of Deep Tissue Injuries
Deep tissue injuries are subcutaneous regions of tissue breakdown associated with excessive mechanical pressure for extended period of time. These wounds are currently clinically undetectable in their early stages and result in severe burdens on not only the patients who suffer from them, but the health care system as well. The goal of this work was to numerically characterize the use of quasi-static ultrasound elastography for detecting formative and progressive deep tissue injuries. In order to numerically characterize the technique, finite-element models of sonographic B-mode imaging and tissue deformation were created....
Source: IEE Transactions on Medical Imaging - July 1, 2014 Category: Biomedical Engineering Source Type: research

Synthetic Generation of Myocardial Blood–Oxygen-Level-Dependent MRI Time Series Via Structural Sparse Decomposition Modeling
This paper aims to identify approaches that generate appropriate synthetic data (computer generated) for cardiac phase-resolved blood–oxygen-level-dependent (CP-BOLD) MRI. CP-BOLD MRI is a new contrast agent- and stress-free approach for examining changes in myocardial oxygenation in response to coronary artery disease. However, since signal intensity changes are subtle, rapid visualization is not possible with the naked eye. Quantifying and visualizing the extent of disease relies on myocardial segmentation and registration to isolate the myocardium and establish temporal correspondences and ischemia detection algo...
Source: IEE Transactions on Medical Imaging - July 1, 2014 Category: Biomedical Engineering Source Type: research

FMT-PCCT: Hybrid Fluorescence Molecular Tomography—X-Ray Phase-Contrast CT Imaging of Mouse Models
The implementation of hybrid fluorescence molecular tomography (FMT) and X-ray computed tomography (CT) has been shown to be a necessary development, not only for combining anatomical with functional and molecular contrast, but also for generating optical images of high accuracy. FMT affords highly sensitive 3-D imaging of fluorescence bio-distribution, but in stand-alone form it offers images of low resolution. It was shown that FMT accuracy significantly improves by considering anatomical priors from CT. Conversely, CT generally suffers from low soft tissue contrast. Therefore utilization of CT data as prior information ...
Source: IEE Transactions on Medical Imaging - July 1, 2014 Category: Biomedical Engineering Source Type: research

Metric Optimization for Surface Analysis in the Laplace-Beltrami Embedding Space
In this paper, we present a novel approach for the intrinsic mapping of anatomical surfaces and its application in brain mapping research. Using the Laplace-Beltrami eigen-system, we represent each surface with an isometry invariant embedding in a high dimensional space. The key idea in our system is that we realize surface deformation in the embedding space via the iterative optimization of a conformal metric without explicitly perturbing the surface or its embedding. By minimizing a distance measure in the embedding space with metric optimization, our method generates a conformal map directly between surfaces with highly...
Source: IEE Transactions on Medical Imaging - July 1, 2014 Category: Biomedical Engineering Source Type: research

Surface-Constrained Nonrigid Registration for Dose Monitoring in Prostate Cancer Radiotherapy
This paper addresses the issue of cumulative dose estimation from cone beam computed tomography (CBCT) images in prostate cancer radiotherapy. It focuses on the dose received by the surfaces of the main organs at risk, namely the bladder and rectum. We have proposed both a surface-constrained dose accumulation approach and its extensive evaluation. Our approach relied on the nonrigid registration (NRR) of daily acquired CBCT images on the planning CT image. This proposed NRR method was based on a Demons-like algorithm, implemented in combination with mutual information metric. It allowed for different levels of geometrical...
Source: IEE Transactions on Medical Imaging - July 1, 2014 Category: Biomedical Engineering Source Type: research