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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 20.

Accuracy evaluation of a new stereophotogrammetry-based functional method for joint kinematic analysis in biomechanics
This article presents a new functional algorithm for the assessment of knee joint parameters, based on a polycentric hinge model for the knee flexion–extension. The proposed algorithm is discussed, identifying its fields of application and its limits. The techniques for estimating the joint parameters from the metrological point of view are analyzed, so as to lay the groundwork for enhancing and eventually replacing predictive methods, currently used in the laboratories of human movement analysis. This article also presents an assessment of the accuracy associated with the whole process of measurement and joint param...
Source: Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine - December 10, 2014 Category: Biomedical Engineering Authors: Galetto, M., Gastaldi, L., Lisco, G., Mastrogiacomo, L., Pastorelli, S. Tags: Original Articles Source Type: research

Computational investigation of the time-dependent contact behaviour of the human tibiofemoral joint under body weight
In this study, the time-dependent contact behaviour of an intact and a meniscectomized human tibiofemoral joint was characterized under body weight using a computational model. Good agreement in the contact area and femoral displacement under static loads were found between model predictions of this study and published experimental measurements. The time-dependent results indicated that as loading time progressed, the contact area and femoral vertical displacement of both intact and meniscectomized joints increased. More load was transferred to the cartilage–cartilage interface over time. However, the portions of loa...
Source: Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine - December 10, 2014 Category: Biomedical Engineering Authors: Meng, Q., Jin, Z., Wilcox, R., Fisher, J. Tags: Original Articles Source Type: research

The effect of in situ/in vitro three-dimensional quantitative computed tomography image voxel size on the finite element model of human vertebral cancellous bone
In conclusion, the image voxel size may have to be considered when the finite element voxel modeling technique is used in clinical applications. (Source: Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine)
Source: Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine - December 10, 2014 Category: Biomedical Engineering Authors: Lu, Y., Engelke, K., Glueer, C.-C., Morlock, M. M., Huber, G. Tags: Technical Note Source Type: research

HPLC analysis and extraction method of SN-38 in brain tumor model after injected by polymeric drug delivery system
SN-38 is a highly potent anticancer drug but its poor solubility in aqueous solvent and adverse side effects limit clinical applications. To overcome these limitations, SN-38-loaded-injectable drug delivery depots have been intratumorally administered in xenograft tumor model in nude mice. The extraction and high performance liquid chromatography (HPLC) were performed in order to determine the amount of SN-38 inside tumors. SN-38 was extracted from tumors using DMSO. HPLC analysis was validated and resulted in linearity over the concentration range from 0.03 to 150 µg/mL (r2 ≥ 0.998). Lower limit of detection (LLO...
Source: Experimental Biology and Medicine - December 9, 2014 Category: Research Authors: Nittayacharn, P., Manaspon, C., Hongeng, S., Nasongkla, N. Tags: Biomedical Engineering Source Type: research

An application of embryonic skin cells to repair diabetic skin wound: A wound reparation trail
Cell therapy has shown its power to promote diabetic chronic wound healing. However, problems of scar formation and loss of appendages have not yet been solved. Our study aims to explore the potential of using embryonic skin cells (ESkCs) to repair diabetic wounds. Circular wound was created on the back of the diabetic mice, and ESkCs stained with CM-DIL were transplanted into the wound. Wound area was recorded at the day 4, 7, 11, and 14 after transplantation. The tissue samples were obtained at week 1, 2, and 3, and the tissue sections were stained by transforming growth factor β1 (TGF-β1), TGF-β3, vascula...
Source: Experimental Biology and Medicine - December 9, 2014 Category: Research Authors: Qian, D. J., Guo, X. K., Duan, H. C., Han, Z. H., Meng, F., Liu, J., Wang, Y. Tags: Biomedical Engineering Source Type: research

Emerging Trends in Heart Valve Engineering: Part I. Solutions for Future.
Abstract As the first section of a multi-part review series, this section provides an overview of the ongoing research and development aimed at fabricating novel heart valve replacements beyond what is currently available for patients. Here we discuss heart valve replacement options that involve a biological component or process for creation, either in vitro or in vivo (tissue-engineered heart valves), and heart valves that are fabricated from polymeric material that are considered permanent inert materials that may suffice for adults where growth is not required. Polymeric materials provide opportunities for cost-...
Source: Annals of Biomedical Engineering - December 9, 2014 Category: Biomedical Engineering Authors: Kheradvar A, Groves EM, Dasi LP, Alavi SH, Tranquillo R, Grande-Allen KJ, Simmons CA, Griffith B, Falahatpisheh A, Goergen CJ, Mofrad MR, Baaijens F, Little SH, Canic S Tags: Ann Biomed Eng Source Type: research

Digital tomosynthesis (DTS) for quantitative assessment of trabecular microstructure in human vertebral bone
The objective of this study was to explore the potential of DTS for describing microstructural, stiffness and stress distribution properties of vertebral cancellous bone.Forty vertebrae (T6, T8, T11, and L3) from 10 cadavers (63–90 years) were scanned using microCT and DTS. Anisotropy (μCT.DA), and the specimen-average and standard deviation of trabecular bone volume fraction (BV/TV), thickness (Tb.Th), number (Tb.N) and separation (Tb.Sp) were obtained using stereology. (Source: Medical Engineering and Physics)
Source: Medical Engineering and Physics - December 8, 2014 Category: Biomedical Engineering Authors: Woong Kim, Daniel Oravec, Srikant Nekkanty, Janardhan Yerramshetty, Edward A. Sander, George W. Divine, Michael J. Flynn, Yener N. Yeni Source Type: research

Facile route to produce chitin nanofibers as precursors for flexible and transparent gas barrier materials.
We report a high pressure homogenization route to produce pure chitin nanofibers (ChNFs) starting with a mildly acidic aqueous dispersion of purified crab α-chitin. The well-dispersed ChNFs with diameter ∼20 nm do not form strong network structures under conditions explored herein and can be directly processed into useful materials, bypassing the need to dissolve the chitin. Dried ChNFs form pure self-standing chitin films with the lowest to-date reported O2 and CO2 permeabilities of 0.006 and 0.018 barrer, respectively. Combined with high flexibility and optical transparency, these materials are ideal candidates for su...
Source: Biomacromolecules - December 8, 2014 Category: Biochemistry Authors: Wu J, Zhang K, Girouard N, Meredith JC Tags: Biomacromolecules Source Type: research

Aortic Valve Function Under Support of a Left Ventricular Assist Device: Continuous vs. Dynamic Speed Support.
Abstract Continuous flow left ventricular devices (CF-LVADs) support the failing heart at a constant speed and alters the loads on the aortic valve. This may cause insufficiency in the aortic valve under long-term CF-LVAD support. The aim of this study is to assess the aortic valve function under varying speed CF-LVAD support. A Medtronic freestyle valve and a Micromed DeBakey CF-LVAD were tested in a mock circulatory system. First, the CF-LVAD was operated at constant speeds between 7500 and 11,500 rpm with 1000 rpm intervals. The mean pump outputs obtained from these tests were applied in varying speed CF-LVAD ...
Source: Annals of Biomedical Engineering - December 6, 2014 Category: Biomedical Engineering Authors: Bozkurt S, van de Vosse FN, Rutten MC Tags: Ann Biomed Eng Source Type: research

Pressure Induced Deep Tissue Injury Explained.
Abstract The paper describes the current views on the cause of a sub-class of pressure ulcers known as pressure induced deep tissue injury (DTI). A multi-scale approach was adopted using model systems ranging from single cells in culture, tissue engineered muscle to animal studies with small animals. This has led to a clear understanding on two damage mechanisms associated with the development of DTI. Direct deformation results from high, but physiologically relevant, strains and is a process that leads to the first signs of cell damage within minutes. Ischaemic damage is caused by occlusion of blood vessels, but t...
Source: Annals of Biomedical Engineering - December 6, 2014 Category: Biomedical Engineering Authors: Oomens CW, Bader DL, Loerakker S, Baaijens F Tags: Ann Biomed Eng Source Type: research

Stick out your tongue
(Inderscience Publishers) The tongue can betray signs of illness, which combined with other symptoms such as a cough, fever, presence of jaundice, headache or bowel habits, can help a physician offer a diagnosis. For people in remote areas who do not have ready access to a physician, a new diagnostic system is reported in the International Journal of Biomedical Engineering and Technology that works to combine the soft inputs of described symptoms with a digital analysis of an image of the patient's tongue. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 5, 2014 Category: Global & Universal Source Type: news

Downsampling of Signals on Graphs Via Maximum Spanning Trees
Downsampling of signals living on a general weighted graph is not as trivial as of regular signals where we can simply keep every other samples. In this paper we propose a simple, yet effective downsampling scheme in which the underlying graph is approximated by a maximum spanning tree (MST) that naturally defines a graph multiresolution. This MST-based method significantly outperforms the two previous downsampling schemes, coloring-based and SVD-based, on both random and specific graphs in terms of computations and partition efficiency quantified by the graph cuts. The benefit of using MST-based downsampling for recently ...
Source: IEEE Transactions on Signal Processing - December 5, 2014 Category: Biomedical Engineering Source Type: research

Sign-Perturbed Sums: A New System Identification Approach for Constructing Exact Non-Asymptotic Confidence Regions in Linear Regression Models
We propose a new system identification method, called Sign–Perturbed Sums (SPS), for constructing non-asymptotic confidence regions under mild statistical assumptions. SPS is introduced for linear regression models, including but not limited to FIR systems, and we show that the SPS confidence regions have exact confidence probabilities, i.e., they contain the true parameter with a user-chosen exact probability for any finite data set. Moreover, we also prove that the SPS regions are star convex with the Least-Squares (LS) estimate as a star center. The main assumptions of SPS are that the noise terms are independent...
Source: IEEE Transactions on Signal Processing - December 5, 2014 Category: Biomedical Engineering Source Type: research

Shrinkage Linear and Widely Linear Complex-Valued Least Mean Squares Algorithms for Adaptive Beamforming
In this paper, shrinkage linear complex-valued least mean squares (SL-CLMS) and shrinkage widely linear complex-valued least mean squares (SWL-CLMS) algorithms are devised for adaptive beamforming. By exploiting the relationship between the noise-free a posteriori and a priori error signals, the SL-CLMS method is able to provide a variable step size to update the weight vector for the adaptive beamformer, significantly enhancing the convergence speed and decreasing the steady-state misadjustment. On the other hand, besides adopting a variable step size determined by minimizing the square of the augmented noise-free a poste...
Source: IEEE Transactions on Signal Processing - December 5, 2014 Category: Biomedical Engineering Source Type: research

Computable Performance Bounds on Sparse Recovery
In this paper, we develop verifiable sufficient conditions and computable performance bounds of $ell_{1}$ -minimization based sparse recovery algorithms in both the noise-free and noisy cases. We define a family of quality measures for arbitrary sensing matrices as a set of optimization problems, and design polynomial-time algorithms with theoretical global convergence guarantees to compute these quality measures. The proposed algorithms solve a series of second-order cone programs, or linear programs. We derive performance bounds on the recovery errors in terms of these quality measures. We also analytically demonstrate t...
Source: IEEE Transactions on Signal Processing - December 5, 2014 Category: Biomedical Engineering Source Type: research

Efficient Coordinated Recovery of Sparse Channels in Massive MIMO
We present a novel channel estimation approach which utilizes the sparsity and common support properties to estimate sparse channels and requires a small number of pilots. Two algorithms based on this approach have been developed that perform Bayesian estimates of sparse channels even when the prior is non-Gaussian or unknown. Neighboring antennas share among each other their beliefs about the locations of active channel taps to perform estimation. The coordinated approach improves channel estimates and also reduces the required number of pilots. Further improvement is achieved by the data-aided version of the algorithm. E...
Source: IEEE Transactions on Signal Processing - December 5, 2014 Category: Biomedical Engineering Source Type: research

Exact Phase Retrieval for a Class of 2-D Parametric Signals
We address the problem of two-dimensional (2-D) phase retrieval from magnitude of the Fourier spectrum. We consider 2-D signals that are characterized by first-order difference equations, which have a parametric representation in the Fourier domain. We show that, under appropriate stability conditions, such signals can be reconstructed uniquely from the Fourier transform magnitude. We formulate the phase retrieval problem as one of computing the parameters that uniquely determine the signal. We show that the problem can be solved by employing the annihilating filter method, particularly for the case when the parameters are...
Source: IEEE Transactions on Signal Processing - December 5, 2014 Category: Biomedical Engineering Source Type: research

Sequential Matrix Diagonalization Algorithms for Polynomial EVD of Parahermitian Matrices
For parahermitian polynomial matrices, which can be used, for example, to characterize space-time covariance in broadband array processing, the conventional eigenvalue decomposition (EVD) can be generalized to a polynomial matrix EVD (PEVD). In this paper, a new iterative PEVD algorithm based on sequential matrix diagonalization (SMD) is introduced. At every step the SMD algorithm shifts the dominant column or row of the polynomial matrix to the zero lag position and eliminates the resulting instantaneous correlation. A proof of convergence is provided, and it is demonstrated that SMD establishes diagonalization faster and...
Source: IEEE Transactions on Signal Processing - December 5, 2014 Category: Biomedical Engineering Source Type: research

Exploiting Base Station Caching in MIMO Cellular Networks: Opportunistic Cooperation for Video Streaming
We propose a novel MIMO cooperation framework called the cache-induced opportunistic cooperative MIMO (Coop-MIMO) for video streaming in backhaul limited multicell MIMO networks. By caching a portion of the video files, the base stations (BSs) opportunistically employ Coop-MIMO transmission to achieve MIMO cooperation gain without expensive payload backhaul. We derive closed form expressions of various video streaming performance metrics for cache-induced opportunistic Coop-MIMO and investigate the impact of BS level caching and key system parameters on the performance. Specifically, we first obtain a mixed fluid-diffusion...
Source: IEEE Transactions on Signal Processing - December 5, 2014 Category: Biomedical Engineering Source Type: research

Efficient Gaussian Sampling for Solving Large-Scale Inverse Problems Using MCMC
The resolution of many large-scale inverse problems using MCMC methods requires a step of drawing samples from a high dimensional Gaussian distribution. While direct Gaussian sampling techniques, such as those based on Cholesky factorization, induce an excessive numerical complexity and memory requirement, sequential coordinate sampling methods present a low rate of convergence. Based on the reversible jump Markov chain framework, this paper proposes an efficient Gaussian sampling algorithm having a reduced computation cost and memory usage, while maintaining the theoretical convergence of the sampler. The main feature of ...
Source: IEEE Transactions on Signal Processing - December 5, 2014 Category: Biomedical Engineering Source Type: research

Min-Max Approximation of Transfer Functions With Application to Filter Design
The objective is to find an approximation model for a transfer function such that the maximum error gain over a specific frequency range is minimized. First, a linear matrix inequality condition characterizing the FS gain of a transfer function is derived by using the generalized Kalman-Yakubovich-Popov lemma, and then a simple iterative approach is proposed to optimize the approximation model. Numerical experiments show that the proposed approach can produce better approximation models over a specific frequency range than some existing approaches. Moreover, it is indicated how to apply the proposed approximation approach ...
Source: IEEE Transactions on Signal Processing - December 5, 2014 Category: Biomedical Engineering Source Type: research

Blind Interference Alignment for Cellular Networks
We propose a blind interference alignment scheme for partially connected cellular networks. The scheme cancels both intracell and intercell interference by relying on receivers with one reconfigurable antenna and by allowing users at the cell edge to be served by all the base stations in their proximity. An outer bound for the degrees of freedom is derived for general partially connected networks with single-antenna receivers when knowledge of the channel state information at the transmitter is not available. It is demonstrated that for symmetric scenarios, this outer bound is achieved by the proposed scheme. On the other ...
Source: IEEE Transactions on Signal Processing - December 5, 2014 Category: Biomedical Engineering Source Type: research

A Convolutive Bounded Component Analysis Framework for Potentially Nonstationary Independent and/or Dependent Sources
Bounded Component Analysis (BCA) is a recent framework which enables development of methods for the separation of dependent as well as independent sources from their mixtures. This paper extends a recent geometric BCA approach introduced for the instantaneous mixing problem to the convolutive mixing problem. The paper proposes novel deterministic convolutive BCA frameworks for the blind source extraction and blind source separation of convolutive mixtures of sources which allows the sources to be potentially nonstationary. The global maximizers of the proposed deterministic BCA optimization settings are proved to be perfec...
Source: IEEE Transactions on Signal Processing - December 5, 2014 Category: Biomedical Engineering Source Type: research

Detectors for Cooperative Mesh Networks With Decode-and-Forward Relays
We consider mesh networks composed of groups of relaying nodes which operate in decode-and-forward mode. Each node from a group relays information to all the nodes in the next group. We study these networks in two setups, one where the nodes have complete state information about the channels through which they receive the signals, and another when they only have the statistics of the channels. We derive recursive expressions for the probabilities of errors of the nodes and present several implementations of detectors used in these networks. We compare the mesh networks with multihop networks formed by a set of parallel sec...
Source: IEEE Transactions on Signal Processing - December 5, 2014 Category: Biomedical Engineering Source Type: research

Biomaterials for Integration with 3-D Bioprinting.
Abstract Bioprinting has emerged in recent years as an attractive method for creating 3-D tissues and organs in the laboratory, and therefore is a promising technology in a number of regenerative medicine applications. It has the potential to (i) create fully functional replacements for damaged tissues in patients, and (ii) rapidly fabricate small-sized human-based tissue models, or organoids, for diagnostics, pathology modeling, and drug development. A number of bioprinting modalities have been explored, including cellular inkjet printing, extrusion-based technologies, soft lithography, and laser-induced forward t...
Source: Annals of Biomedical Engineering - December 5, 2014 Category: Biomedical Engineering Authors: Skardal A, Atala A Tags: Ann Biomed Eng Source Type: research

Scaffold-based Anti-infection Strategies in Bone Repair.
Abstract Bone fractures and non-union defects often require surgical intervention where biomaterials are used to correct the defect, and approximately 10% of these procedures are compromised by bacterial infection. Currently, treatment options are limited to sustained, high doses of antibiotics and surgical debridement of affected tissue, leaving a significant, unmet need for the development of therapies to combat device-associated biofilm and infections. Engineering implants to prevent infection is a desirable material characteristic. Tissue engineered scaffolds for bone repair provide a means to both regenerate b...
Source: Annals of Biomedical Engineering - December 5, 2014 Category: Biomedical Engineering Authors: Johnson CT, García AJ Tags: Ann Biomed Eng Source Type: research

Measurement of Hybrid III Head Impact Kinematics Using an Accelerometer and Gyroscope System in Ice Hockey Helmets.
This study compared kinematics from an accelerometer and gyroscope-containing system to reference measures. A Hybrid III (HIII) adult male anthropometric test device head and neck was fit with two helmet brands, each instrumented with gForce Tracker (GFT) sensor systems in four locations. Helmets were impacted at various speeds and directions. Regression relationships between GFT-measured and reference peak kinematics were quantified, and influence of impact direction, sensor location, and helmet brand was evaluated. The relationship between the sensor output and the reference acceleration/velocity experienced by the head ...
Source: Annals of Biomedical Engineering - December 5, 2014 Category: Biomedical Engineering Authors: Allison MA, Kang YS, Maltese MR, Bolte JH, Arbogast KB Tags: Ann Biomed Eng Source Type: research

Modeling and Simulation of Coupled Cell Proliferation and Regulation in Heterogeneous Tissue.
Abstract The primary objective of this work is to develop a computational framework that efficiently simulates the time-transient proliferation of cellular tissue, with heterogeneous microstructure, utilizing two strongly-coupled conservation laws: Conservation Law 1: comprises (a) rate of change of cells, (b) cellular migration, (c) cellular proliferation controlled by a cell mitosis regulating chemical, (d) cell apoptosis and Conservation Law 2: comprises (a) rate of change of the cell mitosis chemical regulator, (b) regulator diffusion, (c) regulator production by cells and (d) regulator decay. Specifically, a s...
Source: Annals of Biomedical Engineering - December 5, 2014 Category: Biomedical Engineering Authors: Zohdi TI Tags: Ann Biomed Eng Source Type: research

Concussion Concerns Extend To Younger Players
For the Ohio State community, Thanksgiving weekend ended in tragedy when 22-year-old football player Kosta Karageorge was found dead of apparent suicide. Karageorge, who had been missing since Nov. 26, was found on Nov. 30 in a dumpster near the school's campus in Columbus, along with a gun and what police said appeared to be a self-inflicted gunshot wound. According to the Washington Post, Karageorge's mother told police that her son had suffered from several concussions. The Columbus Dispatch reported that a few days before his body was found, Karageorge had texted his mother, saying, "I am sorry if I am an embarrassme...
Source: Healthy Living - The Huffington Post - December 4, 2014 Category: Consumer Health Advice Source Type: news

The Devastating Health Impact Of Concussion May Start Earlier Than We Thought
For the Ohio State community, Thanksgiving weekend ended in tragedy when 22-year-old football player Kosta Karageorge was found dead of apparent suicide. Karageorge, who had been missing since Nov. 26, was found on Nov. 30 in a dumpster near the school's campus in Columbus, along with a gun and what police said appeared to be a self-inflicted gunshot wound. According to the Washington Post, Karageorge's mother told police that her son had suffered from several concussions. The Columbus Dispatch reported that a few days before his body was found, Karageorge had texted his mother, saying, "I am sorry if I am an embarrassme...
Source: Science - The Huffington Post - December 4, 2014 Category: Science Source Type: news

Curvelet based automatic segmentation of supraspinatus tendon from ultrasound image: a focused assistive diagnostic method
Conclusions: The segmentation of SSP tendon from ultrasound images helps in focused, accurate and more reliable diagnosis which has been verified with the help of two experienced radiologists. The specificity and sensitivity for accurate detection of partial and full thickness tears has been considerably increased after segmentation when compared with existing literature. (Source: BioMedical Engineering OnLine)
Source: BioMedical Engineering OnLine - December 4, 2014 Category: Biomedical Engineering Authors: Rishu GuptaIrraivan ElamvazuthiSarat DassIbrahima FayePandian VasantJohn GeorgeFaizatul Izza Source Type: research

Human-Centric Image Categorization Based on Poselets
Abstract In daily life, one kind of images are common, in which many people are present and performing certain activities. We call these images human-centric images. As the number of such images gets increasingly larger, to organize and access them efficiently becomes urgent. Since the categories of human-centric images are determined by human activities in the images, in this paper, we propose to classify human-centric images by analyzing poses of all humans in them. Specifically, first, we introduce the notion of poselets, which represent parts of poses of humans and a method to detect human based on the posele...
Source: Sensing and Imaging - December 4, 2014 Category: Biomedical Engineering Source Type: research

Biomechanics-Based Curvature Estimation for Ultrasound-guided Flexible Needle Steering in Biological Tissues.
Abstract Needle-based procedures are commonly performed during minimally invasive surgery for treatment and diagnosis. Accurate needle tip placement is important for the success of the procedures. Misplacement of the needle tip might cause unsuccessful treatment or misdiagnosis. Robot-assisted needle insertion systems have been developed in order to steer flexible bevel-tipped needles. However, current systems depend on the information of maximum needle curvature, which is estimated by performing prior insertions. This work presents a new three-dimensional flexible needle steering system which integrates an optimal...
Source: Annals of Biomedical Engineering - December 3, 2014 Category: Biomedical Engineering Authors: Moreira P, Misra S Tags: Ann Biomed Eng Source Type: research

Bio-Chemo-Mechanical Models of Vascular Mechanics.
Abstract Models of vascular mechanics are necessary to predict the response of an artery under a variety of loads, for complex geometries, and in pathological adaptation. Classic constitutive models for arteries are phenomenological and the fitted parameters are not associated with physical components of the wall. Recently, microstructurally-linked models have been developed that associate structural information about the wall components with tissue-level mechanics. Microstructurally-linked models are useful for correlating changes in specific components with pathological outcomes, so that targeted treatments may b...
Source: Annals of Biomedical Engineering - December 3, 2014 Category: Biomedical Engineering Authors: Kim J, Wagenseil JE Tags: Ann Biomed Eng Source Type: research

Effects of Degree of Surgical Correction for Flatfoot Deformity in Patient-Specific Computational Models.
Abstract A cohort of adult acquired flatfoot deformity rigid-body models was developed to investigate the effects of isolated tendon transfer with successive levels of medializing calcaneal osteotomy (MCO). Following IRB approval, six diagnosed flatfoot sufferers were subjected to magnetic resonance imaging (MRI) and their scans used to derive patient-specific models. Single-leg stance was modeled, constrained solely through physiologic joint contact, passive soft-tissue tension, extrinsic muscle force, body weight, and without assumptions of idealized mechanical joints. Surgical effect was quantified using simulat...
Source: Annals of Biomedical Engineering - December 3, 2014 Category: Biomedical Engineering Authors: Spratley EM, Matheis EA, Hayes CW, Adelaar RS, Wayne JS Tags: Ann Biomed Eng Source Type: research

Engineering Complex Orthopaedic Tissues Via Strategic Biomimicry.
The objective of strategic biomimicry is to avoid over-engineering by establishing what needs to be learned from nature and defining the essential matrix characteristics that must be reproduced in scaffold design. Application of this engineering strategy for the regeneration of the most common musculoskeletal tissue units (e.g., bone-ligament-bone, muscle-tendon-bone, cartilage-bone) will be discussed in this review. It is anticipated that these exciting efforts will enable integrative and functional repair of soft tissue injuries, and moreover, lay the foundation for the development of composite tissue systems and ultimat...
Source: Annals of Biomedical Engineering - December 3, 2014 Category: Biomedical Engineering Authors: Qu D, Mosher CZ, Boushell MK, Lu HH Tags: Ann Biomed Eng Source Type: research

Challenges in the Modeling of Wound Healing Mechanisms in Soft Biological Tissues.
Abstract Numerical models have become one of the most powerful tools in biomechanics and mechanobiology allowing highly detailed simulations. One of the fields in which they have broadly evolved during the last years is in soft tissue modeling. Particularly, wound healing in the skin is one of the processes that has been approached by computational models due to the difficulty of performing experimental investigations. During the last decades wound healing simulations have evolved from numerical models which considered only a few number of variables and simple geometries to more complex approximations that take int...
Source: Annals of Biomedical Engineering - December 2, 2014 Category: Biomedical Engineering Authors: Valero C, Javierre E, García-Aznar JM, Menzel A, Gómez-Benito MJ Tags: Ann Biomed Eng Source Type: research