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This page shows you the 20 most read items in the past 30 days within this specialty in the MedWorm directory.

Scaling-up vaccine production: implementation aspects of a biomass growth observer and controller.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study considers two aspects of the implementation of a biomass growth observer and specific growth rate controller in scale-up from small- to pilot-scale bioreactors towards a feasible bulk production process for whole-cell vaccine against whooping cough. The first is the calculation of the oxygen uptake rate, the starting point for online monitoring and control of biomass growth, taking into account the dynamics in the gas-phase. Mixing effects and delays are caused by amongst others the headspace and tubing to the analyzer. These gas phase dynamics are modelled using knowledge of the system in order to reconstruct o...
Source: Bioprocess and Biosystems Engineering - July 31, 2008 Category: Biomedical Engineering Authors: Soons ZI, van den Ijssel J, van der Pol LA, van Straten G, van Boxtel AJ Tags: Bioprocess Biosyst Eng Source Type: journals

Finite-Element Analysis and In Vitro Experiments of Placement Configurations Using Triple Antennas in Microwave Hepatic AblationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study presents analyses of triple-antenna configurations and designs for microwave (MW) hepatic ablation using 3-D finite-element (FE) analyses verified by in vitro experiments. Treatment of hepatic cancer often requires removal or destruction of large volume lesions. Using multiple antennas offers a potential solution for creating ablation zones with larger dimensions, as well as varied geometrical shapes. We performed both 3-D FE analyses and in vitro experiments using three identical open-tip MW antennas simultaneously, placing them in three types of configurations—“linear array,” “trian...
Source: IEEE Transactions on Biomedical Engineering - October 23, 2009 Category: Biomedical Engineering Source Type: journals

A Tissue Framework for Simulating the Effects of Gastric Electrical Stimulation and In Vivo ValidationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gastric pacing is used to modulate normal or abnormal gastric slow-wave activity for therapeutic purposes. New protocols are required that are optimized for motility outcomes and energy efficiency. A computational tissue model was developed, incorporating smooth muscle and interstitial cell of Cajal layers, to enable predictive simulations of slow-wave entrainment efficacy under different pacing frequencies. Concurrent experimental validation was performed via high-resolution entrainment mapping in a porcine model (bipolar pacing protocol: 2 mA amplitude; 400 ms pulsewidth; 17-s period; midcorpus). Entrained gastric slow-w...
Source: IEEE Transactions on Biomedical Engineering - November 19, 2009 Category: Biomedical Engineering Source Type: journals

In Vivo High-ResolutionConductivity Imaging of the Human Leg Using MREIT: The First Human ExperimentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present the first in vivo cross-sectional conductivity image of the human leg with 1.7 mm pixel size using the magnetic resonance electrical impedance tomography (MREIT) technique. After a review of its experimental protocol by an Institutional Review Board (IRB), we performed MREIT imaging experiments of four human subjects using a 3 T MRI scanner. Adopting thin and flexible carbon–hydrogel electrodes with a large surface area and good contact, we could inject as much as 9 mA current in a form of 15 ms pulse into the leg without producing a painful sensation and motion artifact. Sequentially injecting two imagin...
Source: IEE Transactions on Medical Imaging - October 30, 2009 Category: Biomedical Engineering Source Type: journals

Experimental and Computational Models for Simulating Sound Propagation Within the Lungs.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An acoustic boundary element model is used to simulate sound propagation in the lung parenchyma and surrounding chest wall. It is validated theoretically and numerically and then compared with experimental studies on lung-chest phantom models that simulate the lung pathology of pneumothorax. Studies quantify the effect of the simulated lung pathology on the resulting acoustic field measured at the phantom chest surface. This work is relevant to the development of advanced auscultatory techniques for lung, vascular, and cardiac sounds within the torso that utilize multiple noninvasive sensors to create acoustic images o...
Source: Journal of Vibration and Acoustics - April 1, 2008 Category: Biomedical Engineering Authors: Acikgoz S, Ozer MB, Royston TJ, Mansy HA, Sandler RH Tags: J Vib Acoust Source Type: journals

IEEE Transactions on Medical Imaging information for authorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: IEE Transactions on Medical Imaging)
Source: IEE Transactions on Medical Imaging - October 30, 2009 Category: Biomedical Engineering Source Type: journals

Anaerobic treatment of winery wastewater in fixed bed reactors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The treatment of winery wastewater in three upflow anaerobic fixed-bed reactors (S9, S30 and S40) with low density floating supports of varying size and specific surface area was investigated. A maximum OLR of 42 g/l day with 80 +/- 0.5% removal efficiency was attained in S9, which had supports with the highest specific surface area. It was found that the efficiency of the reactors increased with decrease in size and increase in specific surface area of the support media. Total biomass accumulation in the reactors was also found to vary as a function of specific surface area and size of the support medium. The Stover-K...
Source: Bioprocess and Biosystems Engineering - October 30, 2009 Category: Biomedical Engineering Authors: Ganesh R, Rajinikanth R, Thanikal JV, Ramanujam RA, Torrijos M Tags: Bioprocess Biosyst Eng Source Type: journals

Cardiac C-Arm CT: A Unified Framework for Motion Estimation and Dynamic CTEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Generating 3-D images of the heart during interventional procedures is a significant challenge. In addition to real time fluoroscopy, angiographic C-arm systems can also now be used to generate 3-D/4-D CT images on the same system. One protocol for cardiac CT uses ECG triggered multisweep scans. A 3-D volume of the heart at a particular cardiac phase is then reconstructed by applying Feldkamp (FDK) reconstruction to the projection images with retrospective ECG gating. In this work we introduce a unified framework for heart motion estimation and dynamic cone-beam reconstruction using motion corrections. The benefits of moti...
Source: IEE Transactions on Medical Imaging - October 30, 2009 Category: Biomedical Engineering Source Type: journals

Approaching Artery Rigid Dynamics in IVUSEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tissue biomechanical properties (like strain and stress) are playing an increasing role in diagnosis and long-term treatment of intravascular coronary diseases. Their assessment strongly relies on estimation of vessel wall deformation. Since intravascular ultrasound (IVUS) sequences allow visualizing vessel morphology and reflect its dynamics, this technique represents a useful tool for evaluation of tissue mechanical properties. Image misalignment introduced by vessel–catheter motion is a major artifact for a proper tracking of tissue deformation. In this work, we focus on compensating and assessing IVUS rigid in-p...
Source: IEE Transactions on Medical Imaging - October 30, 2009 Category: Biomedical Engineering Source Type: journals

Table of contentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: IEEE Transactions on Biomedical Circuits and Systems)
Source: IEEE Transactions on Biomedical Circuits and Systems - September 30, 2009 Category: Biomedical Engineering Source Type: journals

Blumlein Configuration for High-Repetition-Rate Pulse Generation of Variable Duration and Polarity Using Synchronized Switch ControlEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Blumlein generators are used in different applications such as radars, lasers, and also recently in various biomedical studies, where the effects of high-voltage nanosecond pulses on biological cells are evaluated. In these studies, it was demonstrated that by applying high-voltage nanosecond pulses to cells, plasma membrane and cell organelles are permeabilized. As suggested in a recent publication, the repetition rate and polarity of nanosecond high-voltage pulses could have an important effect on the electropermeabilization process, and consequently, on the observed phenomena. Therefore, we designed a new Blumlein confi...
Source: IEEE Transactions on Biomedical Engineering - October 23, 2009 Category: Biomedical Engineering Source Type: journals

Special issue on multivariate microscopy image analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: IEE Transactions on Medical Imaging)
Source: IEE Transactions on Medical Imaging - September 30, 2009 Category: Biomedical Engineering Source Type: journals

Analysis of the Mechanism of Action of Deep Brain Stimulation Using the Concepts of Dither Injection and the Equivalent NonlinearityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Deep brain stimulation (DBS) is a widely applied clinical procedure for the alleviation of pathological neural activity, and is particularly effective in suppressing the symptoms of Parkinson's disease. The mechanisms of action of DBS remain to be fully elucidated. In this paper, we present an application to DBS of the concepts of dither injection and equivalent nonlinearity from the theory of nonlinear feedback control systems. We propose that this model provides a framework for understanding the mechanism by which an injected high-frequency signal can quench undesired oscillations in closed-loop systems of interacting ne...
Source: IEEE Transactions on Biomedical Engineering - October 30, 2009 Category: Biomedical Engineering Source Type: journals

Special issue on multivariate microscopy image analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: IEE Transactions on Medical Imaging)
Source: IEE Transactions on Medical Imaging - October 30, 2009 Category: Biomedical Engineering Source Type: journals

cooperation and competition [From the Editor]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
One of the great aspects of biomedical engineering and life science in general is that all of us who are practitioners for the most part work together. The scientific enterprise is devoted to a better understanding of our world and, through that understanding, improving the quality of life of the world's population. We do this by learning from each other and each of us adding something to what we have learned. We learn by reading, listening to, and exchanging the ideas with our colleagues in the field. Most scientists and engineers not only carry out this type of exchange with colleagues in their own field but also look to...
Source: IEEE Engineering in Medicine and Biology - April 17, 2009 Category: Biomedical Engineering Source Type: info

Modeling and simulation of flexible needlesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Needle insertion is performed in many clinical and therapeutic procedures. Tissue displacement and needle bending which result from needle–tissue interaction make accurate targeting difficult. For performing physicians to gain essential needle targeting skills, needle insertion simulators can be used for training. An accurate needle bending model is essential for such simulators. These bending models are also needed for needle path planning.In this paper, three different models are presented to simulate the deformations of a needle. The first two models use the finite element method and take the geometric nonli...
Source: Medical Engineering and Physics - August 12, 2009 Category: Biomedical Engineering Authors: Orcun Goksel, Ehsan Dehghan, Septimiu E. Salcudean Tags: Papers Source Type: journals

CAD/CAM bilateral ear prostheses construction for Treacher Collins syndrome patients using laser scanning and rapid prototyping.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ear defects in patients affected by Treacher Collins syndrome necessitate the replacement of the existing anatomic residuals of the ears with custom-made prostheses. This paper describes a multidisciplinary protocol involving both medicine and computer-aided design/computer-aided manufacturing for manufacturing ear prostheses. Using innovative prototyping technologies together with conventional silicone processing procedures, a step-by-step procedure is presented. The complete workflow includes laser scanning of the defective regions of a patient's face, the use of 3D anatomic models from an ear digital library and rap...
Source: Computer Methods in Biomechanics and Biomedical Engineering - October 19, 2009 Category: Biomedical Engineering Authors: Ciocca L, De Crescenzio F, Fantini M, Scotti R Tags: Comput Methods Biomech Biomed Engin Source Type: journals

Worst-Case Robust MIMO Transmission With Imperfect Channel KnowledgeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective is to maximize the worst-case received signal-to-noise ratio (SNR), or to minimize the worst-case Chernoff bound of the error probability, thus leading to a maximin problem. Moreover, we also consider the QoS problem, as a complement of the maximin design, which minimizes the transmit power consumption and meanwhile keeps the received SNR above a given threshold for any channel realization in the ellipsoid. It is shown that, for a general class of power constraints, both the maximin and QoS problems can be equivalently transformed into convex problems, or even further into semidefinite programs (SDPs), thus e...
Source: IEEE Transactions on Signal Processing - July 23, 2009 Category: Biomedical Engineering Source Type: journals

Blutdruckregelung im Umfeld chirurgischer Interventionen / Blood pressure control in the area of surgical interventionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Biomedizinische Technik/Biomedical Engineering 54 (5): 299-306 Abstract For specific surgical interventions, such as aortic stent implantation, it might be temporarily necessary to decrease mean arterial pressure to rather low levels (around 40 mm Hg). Such hypotensive pressure levels are necessary to avoid intra- and postoperative intricacies. Traditionally, the drug Nitroprussidnatrium is used for this task. To adjust the correct amount of drug to reach the target pressure as fast as possible and without overshoot, the anaesthetists typically use empirical knowledge and might need several minutes until the target point ...
Source: Biomedizinische Technik/Biomedical Engineering - October 6, 2009 Category: Biomedical Engineering Source Type: journals

Methods for Compensating for Variable Electrode Contact in EITEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Electrical impedance tomography (EIT) is an imaging modality that currently shows promise for the detection and characterization of breast cancer. A very significant problem in EIT imaging is the proper modeling of the interface between the body and the electrodes. We have found empirically that it is very difficult, in a clinical setting, to assure that all electrodes make satisfactory contact with the body. In addition, we have observed a capacitive effect at the skin/electrode boundary that is spatially heterogeneous. To compensate for these problems, we have developed a hybrid nonlinear–linear reconstruction alg...
Source: IEEE Transactions on Biomedical Engineering - November 19, 2009 Category: Biomedical Engineering Source Type: journals