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An Atomic-Level Look at HIV Accompliceemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
NIGMS-funded biochemists have determined the structure of a precursor to a semen protein that makes cells more vulnerable to HIV. (Source: NIGMS - Results)
Source: NIGMS - Results - November 20, 2009 Category: Biomedical Science Source Type: news

Statistical Technique Finds Gene Regulation Sitesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
NIGMS-funded computer scientists have discovered a way to scan the genome for regions involved in gene regulation without prior knowledge of transcription factors. (Source: NIGMS - Results)
Source: NIGMS - Results - November 20, 2009 Category: Biomedical Science Source Type: news

PKM2 Tyrosine Phosphorylation and Glutamine Metabolism Signal a Different View of the Warburg Effect.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
New evidence suggests that the receptor tyrosine kinase FGFR1 (fibroblast growth factor receptor 1) directly phosphorylates pyruvate kinase M2 (PKM2), resulting in reduced conversion of phosphoenolpyruvate to pyruvate, which is further catabolized to lactate by lactate dehydrogenase A. Mutation of the critical tyrosine Tyr(105) to Phe rendered PKM2 more active but was associated with decreased cellular lactate production, increased oxygen consumption, and decreased hypoxic cell proliferation relative to wild-type PKM2. The apparent paradoxical effect of growth signaling through tyrosine phosphorylation, which decreases...
Source: Science Signaling - November 20, 2009 Category: Biomedical Science Authors: Dang CV Tags: Sci Signal Source Type: journals

Acetylation Goes Global: The Emergence of Acetylation Biology.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
For the first 30 years since its discovery, reversible protein acetylation has been studied and understood almost exclusively in the context of histone modification and gene transcription. With the discovery of non-histone acetylated proteins and acetylation-modifying enzymes in cellular compartments outside the nucleus, the regulatory potential of reversible acetylation has slowly been recognized in the last decade. However, the scope of protein acetylation involvement in complex biological processes remains uncertain. The recent development of new technology has enabled, for the first time, the identification and qua...
Source: Science Signaling - November 20, 2009 Category: Biomedical Science Authors: Norris KL, Lee JY, Yao TP Tags: Sci Signal Source Type: journals

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The Warburg effect describes a pro-oncogenic metabolism switch such that cancer cells take up more glucose than normal tissue and favor incomplete oxidation of glucose even in the presence of oxygen. To better understand how tyrosine kinase signaling, which is commonly increased in tumors, regulates the Warburg effect, we performed phosphoproteomic studies. We found that oncogenic forms of fibroblast growth factor receptor type 1 inhibit the pyruvate kinase M2 (PKM2) isoform by direct phosphorylation of PKM2 tyrosine residue 105 (Y(105)). This inhibits the formation of active, tetrameric PKM2 by disrupting binding of t...
Source: Science Signaling - November 20, 2009 Category: Biomedical Science Authors: Hitosugi T, Kang S, Vander Heiden MG, Chung TW, Elf S, Lythgoe K, Dong S, Lonial S, Wang X, Chen GZ, Xie J, Gu TL, Polakiewicz RD, Roesel JL, Boggon TJ, Khuri FR, Gilliland DG, Cantley LC, Kaufman J, Chen J Tags: Sci Signal Source Type: journals

Trypanosoma cruzi Targets Akt in Host Cells as an Intracellular Antiapoptotic Strategy.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The parasite Trypanosoma cruzi, which causes Chagas' disease, differentiates in the cytosol of its host cell and then replicates and spreads infection, processes that require the long-term survival of the infected cells. Here, we show that in the cytosol, parasite-derived neurotrophic factor (PDNF), a trans-sialidase that is located on the surface of T. cruzi, is both a substrate and an activator of the serine-threonine kinase Akt, an antiapoptotic molecule. PDNF increases the expression of the gene that encodes Akt while suppressing the transcription of genes that encode proapoptotic factors. Consequently, PDNF elicit...
Source: Science Signaling - November 20, 2009 Category: Biomedical Science Authors: Chuenkova MV, Pereiraperrin M Tags: Sci Signal Source Type: journals

ALBAclone (Alba Bioscience Limited)email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: What's New at CBER)
Source: What's New at CBER - November 19, 2009 Category: Biomedical Science Source Type: organizations

Herbal Medicine May Counter Pain Killer's Liver Toxicityemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
A well-known Eastern herbal supplement may help avoid the most common cause of liver transplantation, according to an NIGMS-supported study. (Source: NIGMS - Results)
Source: NIGMS - Results - November 19, 2009 Category: Biomedical Science Source Type: news

Multitasking may be Achilles heel for hepatitis Cemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Hepatitis C, a formidable virus that affects 130 million people worldwide, is nursing some pretty impressive bruises. By knocking out sections and subsections of one of its proteins, scientists reveal weak spots in the virus’s armor and gain new momentum for developing drug targets for sufferers of the disease. (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - November 19, 2009 Category: Biomedical Science Source Type: organizations

NIGMS ‘Challenge’ Areas Get Millions in Recovery Act Fundsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
NIGMS has invested $16.4 million of Recovery Act funds to jump-start a range of two-year research projects that address critical gaps in the basic biomedical and behavioral sciences. (Source: NIGMS - What's New)
Source: NIGMS - What's New - November 19, 2009 Category: Biomedical Science Source Type: organizations

Scientists identify DNA that regulates antibody productionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
When foreign invaders trip the immune system’s alarm, antibodies need to be specially sculpted to attack them head on. New research now shows that gene segments called enhancers control the reshuffling of antibody genes that makes such a precise and coordinated attack possible. (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - November 19, 2009 Category: Biomedical Science Source Type: organizations

New research helps explain why bird flu has not caused a pandemicemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Research suggests human to human transmission of H5 influenza viruses is unlikely - News Release (Source: Imperial College News)
Source: Imperial College News - November 19, 2009 Category: Biomedical Science Source Type: organizations

Synchronous culture of Plasmodium falciparum at high parasitemia levelsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
et, Amalia Diez & José M Bautista This protocol describes a method for preparing cultures of Plasmodium falciparum synchronized at any intraerythrocytic stage. Using this method, around 60% parasitized cells may be obtained. On the basis of Trager and Jensen's original continuous culture method, our approach relies on the use of (Source: Nature Protocols)
Source: Nature Protocols - November 19, 2009 Category: Biomedical Science Authors: Azar RadfarDarío MéndezCarlos MonerizMaría LinaresPatricia Marín-GarcíaAntonio PuyetAmalia DiezJosé M Bautista Tags: Protocol Source Type: journals

Global identification of protein kinase substrates by protein microarray analysisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
l Snyder Herein, we describe a protocol for the global identification of in vitro substrates targeted by protein kinases using protein microarray technology. Large numbers of fusion proteins tagged at their carboxy-termini are purified in 96-well format and spotted in duplicate onto amino-silane-coated slides in a (Source: Nature Protocols)
Source: Nature Protocols - November 19, 2009 Category: Biomedical Science Authors: Janine MokHogune ImMichael Snyder Tags: Protocol Source Type: journals

Determination of gene expression patterns using in situ hybridization to Drosophila testesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
We describe a whole-mount RNA in situ hybridization (ISH) method optimized for detection of the cellular and subcellular distributions of specific mRNA within Drosophila testes and male genital tract. Digoxygenin (dig)-labeled antisense RNA probes are in vitro transcribed from a template synthesized (Source: Nature Protocols)
Source: Nature Protocols - November 19, 2009 Category: Biomedical Science Authors: Ceri A MorrisElizabeth BensonHelen White-Cooper Tags: Protocol Source Type: journals

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivoemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo Nature Protocols 4, 1798 (2009). doi:10.1038/nprot.2009.191 Authors: Florence Debacq-Chainiaux, Jorge D Erusalimsky, Judith Campisi & Olivier Toussaint Normal cells can permanently lose the ability to proliferate when challenged by potentially oncogenic stress, a process termed cellular senescence. Senescence-associated beta-galactosidase (SA-βgal) activity, detectable at pH 6.0, permits the identification of senescent cells in culture and mammalian tissues. Here we describe...
Source: Nature Protocols - November 19, 2009 Category: Biomedical Science Authors: Florence Debacq-ChainiauxJorge D ErusalimskyJudith CampisiOlivier Toussaint Tags: Protocol Source Type: journals

Hydrodynamic modulation of embryonic stem cell differentiation by rotary orbital suspension cultureemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Embryonic stem cells (ESCs) can differentiate into all somatic cell types, but the development of effective strategies to direct ESC fate is dependent upon defining environmental parameters capable of influencing cell phenotype. ESCs are commonly differentiated via cell aggregates referred to as embryoid bodies (EBs), but current culture methods, such as hanging drop and static suspension, yield relatively few or heterogeneous populations of EBs. Alternatively, rotary orbital suspension culture enhances EB formation efficiency, cell yield, and homogeneity without adversely affecting differentiation. Thus, the objective of ...
Source: Biotechnology and Bioengineering - November 19, 2009 Category: Biomedical Science Authors: Carolyn Y. Sargent, Geoffrey Y. Berguig, Melissa A. Kinney, Luke A. Hiatt, Richard L. Carpenedo, R. Eric Berson, Todd C. McDevitt Source Type: journals

How Viruses Destroy Bacteriaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
A team of NIGMS-supported researchers is exploring how viruses, armed with transformer-like weapons, attack bacteria. The findings may aid in the treatment of bacterial infections. (Source: NIGMS - Results)
Source: NIGMS - Results - November 18, 2009 Category: Biomedical Science Source Type: news

Prolonged Administration Enhances the Renoprotective Effect of Pentoxifylline via Anti-Inflammatory Activity in Streptozotocin-Induced Diabetic Nephropathyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This study investigates whether prolonged administration of PTX (40 mg/kg, per oral) is effective in streptozotocin-induced diabetic nephropathy. The amount of urinary protein was higher in the diabetic rats than in the control rats. The amount remained unchanged after 4 weeks and decreased after 8 weeks of PTX treatment. Accumulation of monocyte chemoattractant peptide-1 (MCP-1) and mouse monoclonal anti-monocyte/macrophage antibody (ED-1) positive cells was higher in untreated diabetic rats than in the control rats. PTX administration ameliorated the urinary MCP-1 excretion and interstitial infiltrati...
Source: Inflammation - November 18, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

Expression and immunolocalization of ERG1 potassium channels in the rat kidneyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  Potassium (K+) channels participate in K+ secretion, K+ recycling, and cell volume regulation and help to maintain the resting potential in mammalian kidneys. Previously, we identified a set of voltage-gated K+ channels (Kv1) in the inner medullary collecting duct of the rat kidney. In the present work, we identified the voltage-gated K+ channel ether-à-go-go-related gene (ERG) in the rat kidney. mRNAs of ERG1a and its N-terminal splice-variant ERG1b were detected. Immunoblots of the cortex and medulla revealed two molecular mass proteins of 135 and 80 kDa, consistent in size with the nonglycos...
Source: Histochemistry and Cell Biology - November 18, 2009 Category: Biomedical Science Tags: Histochemistry and Cell Biology Source Type: journals

Computational simulation of spontaneous bone straightening in growing children.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Periosteal surface pressures have been shown to inhibit bone formation and induce bone resorption, while tensile strains perpendicular to the periosteal surface have been shown to inhibit bone resorption and induce new bone deposition. A new computational model was developed to incorporate these experimental findings into simulations of spontaneous bone straightening in children with congenital posteromedial bowing of the tibia. Three-dimensional finite element models of the periosteum were used to determine the relationships between the defect angle and the distribution of bone surface pressures and strains due to gro...
Source: Biomechanics and Modeling in Mechanobiology - November 18, 2009 Category: Biomedical Science Authors: Carpenter RD, Carter DR Tags: Biomech Model Mechanobiol Source Type: journals

Eight religions come together at Imperial to mark National InterFaith Weekemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Representatives from different religions share insights and dialogue at Imperial- News (Source: Imperial College News)
Source: Imperial College News - November 18, 2009 Category: Biomedical Science Source Type: organizations

Students plan record-breaking zero emission ‘supercar’ journey along world’s longest roademail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Imperial’s Racing Green Endurance team showcases its electric supercar at the College - News (Source: Imperial College News)
Source: Imperial College News - November 18, 2009 Category: Biomedical Science Source Type: organizations

Cytoskeleton Directs Chromosome Dance in Meiosisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
New findings by NIGMS-supported scientists show that the cell's cytoskeleton, which moves things around in the cell, plays a critical role in helping chromosomes find mates and pair up during meiosis. (Source: NIGMS - Results)
Source: NIGMS - Results - November 17, 2009 Category: Biomedical Science Source Type: news

Shaham and Chalasani named winners of 2009 Blavatnik Awardsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Associate Professor Shai Shaham and Postdoctoral Fellow Sreekanth H. Chalasani, who were named finalists in the third annual competition in September, were honored last night with six other winners at the New York Academy of Sciences’ Science and the City Gala. (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - November 17, 2009 Category: Biomedical Science Source Type: organizations

Stimulus Funds Go to Stem Cell Research in Nebraskaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
A Nebraska researcher was recently selected to receive federal stimulus funds to extend his work on induced pluripotent stem cells. (Source: NIGMS - Results)
Source: NIGMS - Results - November 17, 2009 Category: Biomedical Science Source Type: news

Antioxidant Has Implications for Treating Cystic Fibrosisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
An antioxidant found in vegetables may help treat inflammation-based disorders like cystic fibrosis, according to a new NIGMS-supported study. (Source: NIGMS - Results)
Source: NIGMS - Results - November 17, 2009 Category: Biomedical Science Source Type: news

Imperial Sustainable Energy Futures MSc scoops Innovation awardemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Imperial course recognised with Institute of Chemical Engineers' Award for Innovation and Excellence (Source: Imperial College News)
Source: Imperial College News - November 17, 2009 Category: Biomedical Science Source Type: organizations

HIV vaccine failure probably caused by virus used, says new researchemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Immunity to adenovirus means some people had a higher risk of HIV infection in STEP Trial - News Release (Source: Imperial College News)
Source: Imperial College News - November 17, 2009 Category: Biomedical Science Source Type: organizations

Scientists discover cells that control inflammation in chronic diseaseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
New kind of immune cell can go out of control in diseases like psoriasis and asthma - News Release (Source: Imperial College News)
Source: Imperial College News - November 17, 2009 Category: Biomedical Science Source Type: organizations

A mechanistic model of infection: why duration and intensity of contacts should be included in models of disease spreademail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: The importance of highly connected individuals, so-called super-spreaders, for disease spread seems to be overestimated when a constant per-contact transmission probability is assumed. This holds particularly for diseases with low basic reproduction numbers. Simulations of disease spread should weight contacts by duration and intensity. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - November 17, 2009 Category: Biomedical Science Authors: Timo Smieszek Source Type: journals

Scientists Guide Immune Cells with Light and Microparticlesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
A team of scientists partly supported by NIGMS has developed a new approach to studying how immune cells chase down bacteria in our bodies. (Source: NIGMS - Results)
Source: NIGMS - Results - November 16, 2009 Category: Biomedical Science Source Type: news

Why Some Drug Combinations Backfireemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Just as some drugs work better together, some drug pairings are counter-productive, according to a new NIGMS-supported study. (Source: NIGMS - Results)
Source: NIGMS - Results - November 16, 2009 Category: Biomedical Science Source Type: news

Imaging study shows HIV particles assembling around its genomeemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The genesis of one the planet’s most lethal viruses, HIV, has been caught on tape. New imaging experiments show individual HIV genomes — strands of RNA — docking on the inner membrane of an infected cell wall as they are ensconced by HIV structural proteins. (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - November 16, 2009 Category: Biomedical Science Source Type: organizations

Predicting Side Effects and Repurposing Drugsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
A team of NIGMS-supported pharmaceutical chemists has devised a method for predicting a drug's close contacts inside the body, providing a new way to identify unwanted interactions and novel therapeutic targets. (Source: NIGMS - What's New)
Source: NIGMS - What's New - November 16, 2009 Category: Biomedical Science Source Type: organizations

Predicting Side Effects and Repurposing Drugsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
As a drug binds to a protein to lower cholesterol or inhibit the growth of breast cancer cells, it also brushes up against thousands of other molecules. These on- and off-target interactions determine a drug's beneficial effect as well as its side effects. Now, a team of pharmaceutical chemists has devised a method for predicting a drug's close contacts inside the body, providing a new way to identify unwanted interactions and novel therapeutic targets. (Source: NIGMS Computing Life)
Source: NIGMS Computing Life - November 16, 2009 Category: Biomedical Science Source Type: consumer

Assessment of risk factors for osteoporosis and fractures in children with meningomyelocele.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: Low-energetic fractures in MMC children may result from metabolic disturbances that are a consequence of excessive renal calcium loss or excessive fatty tissue content. PMID: 19919941 [PubMed - as supplied by publisher] (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - November 16, 2009 Category: Biomedical Science Authors: Okurowska-Zawada B, Konstantynowicz J, Kułak W, Kaczmarski M, Piotrowska-Jastrzębska J, Sienkiewicz D, Paszko-Patej G Tags: Adv Med Sci Source Type: journals

Sleep-wake schedules in preschool children who snore.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion: In preschool age children, when the daytime nap begins to disappear, snoring may have an effect on daytime schedule through an increased need for daytime sleep. PMID: 19919942 [PubMed - as supplied by publisher] (Source: Advances in Medical Sciences)
Source: Advances in Medical Sciences - November 16, 2009 Category: Biomedical Science Authors: Wasilewska J, Kaczmarski M, Citko D, Kowalczuk-Krystoń M, Protas PT, Semeniuk J Tags: Adv Med Sci Source Type: journals

Rector of Imperial College Londonemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Sir Roy Anderson to return focus to international research and advisory career; Sir Keith O'Nions is Acting Rector from 1 January 2010 - News release (Source: Imperial College News)
Source: Imperial College News - November 16, 2009 Category: Biomedical Science Source Type: organizations

Imperial inspires school pupils with creative scienceemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
School pupils find out about the creativity of science as Imperial joins its neighbours for Creative Quarter 2009 - News (Source: Imperial College News)
Source: Imperial College News - November 16, 2009 Category: Biomedical Science Source Type: organizations

Sex Hormones and Immunity to Infectionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Why sex mattersAmong human and nonhuman animals, the prevalence and intensity of infection typically is higher in males than females and may reflect differences in exposure as well as susceptibility to pathogens. Elevated immunity among females is a double-edged sword in which it is beneficial against infectious diseases but is detrimental in terms of increased development of autoimmune ... (Source: Springer Biomedical Sciences titles)
Source: Springer Biomedical Sciences titles - November 14, 2009 Category: Biomedical Science Tags: Immunology Source Type: organizations

A microscale protein NMR sample screening pipeline.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
As part of efforts to develop improved methods for NMR protein sample preparation and structure determination, the Northeast Structural Genomics Consortium (NESG) has implemented an NMR screening pipeline for protein target selection, construct optimization, and buffer optimization, incorporating efficient microscale NMR screening of proteins using a micro-cryoprobe. The process is feasible because the newest generation probe requires only small amounts of protein, typically 30-200 mug in 8-35 mul volume. Extensive automation has been made possible by the combination of database tools, mechanization of key process step...
Source: Journal of Bimolecular NMR - November 14, 2009 Category: Biomedical Science Authors: Rossi P, Swapna GV, Huang YJ, Aramini JM, Anklin C, Conover K, Hamilton K, Xiao R, Acton TB, Ertekin A, Everett JK, Montelione GT Tags: J Biomol NMR Source Type: journals

Platelet PGD Test System (2009)email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Substantially Equivalent 510(k) submission; cleared 11/10/2009 (Source: What's New at CBER)
Source: What's New at CBER - November 13, 2009 Category: Biomedical Science Source Type: organizations

Schisantherin A Exhibits Anti-inflammatory Properties by Down-Regulating NF-κB and MAPK Signaling Pathways in Lipopolysaccharide-Treated RAW 264.7 Cellsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Abstract  Schisantherin A, a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera, has been used as an antitussive, tonic, and sedative agent under the name of Wuweizi in Chinese traditional medicine. In the present study, we carry out a screening program to identify the anti-inflammatory potentials of schisantherin A. We found that schisantherin A reduced lipopolysaccharide (LPS (1 mg/L))-induced levels of TNF-α, IL-6, NO, and PGE2 (p < 0.01 or p < 0.05), and also reduced levels of iNOS and COX-2 in RAW 264.7 macrophages in a concentration-dependent manner. We fu...
Source: Inflammation - November 13, 2009 Category: Biomedical Science Tags: Inflammation Source Type: journals

Erratum to: Ultrastructural characterization of giant endosomes induced by GTPase-deficient Rab5email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Content Type Journal ArticleCategory ErratumDOI 10.1007/s00418-009-0660-7Authors Catherine Sem Wegner, The Norwegian Radium Hospital, Oslo University Hospital Department of Biochemistry, Institute for Cancer Research Montebello 0310 Oslo NorwayLene Malerød, The Norwegian Radium Hospital, Oslo University Hospital Department of Biochemistry, Institute for Cancer Research Montebello 0310 Oslo NorwayNina Marie Pedersen, The Norwegian Radium Hospital, Oslo University Hospital Department of Biochemistry, Institute for Cancer Research Montebello 0310 Oslo NorwayCinzia Progida, University of Oslo Department of Molecular Biosc...
Source: Histochemistry and Cell Biology - November 13, 2009 Category: Biomedical Science Tags: Histochemistry and Cell Biology Source Type: journals

Notes to Contributorsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 13, 2009 Category: Biomedical Science Tags: Frontmatter Source Type: journals

Editorial Boardemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 13, 2009 Category: Biomedical Science Tags: Frontmatter Source Type: journals

Contentsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 13, 2009 Category: Biomedical Science Tags: Frontmatter Source Type: journals

Mastheademail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 13, 2009 Category: Biomedical Science Source Type: journals

Draft Guidance for Industry: Recommendations for the Assessment of Blood Donor Suitability, Blood Product Safety, and Preservation of the Blood Supply in Response to Pandemic (H1N1) 2009 Virusemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
11/13/2009 (Source: What's New at CBER)
Source: What's New at CBER - November 13, 2009 Category: Biomedical Science Source Type: organizations