Biomedical Science 
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Title page/Editorial Board
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(Source: Medical Hypotheses)
Source: Medical Hypotheses - February 3, 2012 Category: Biomedical Science Source Type: research
p27Kip1 controls cytokinesis via the regulation of citron kinase activationEmail this article to a colleague.
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p27Kip1 (p27) acts as a tumor suppressor by inhibiting cyclin–cyclin-dependent kinase (cyclin-CDK) activity. However, mice expressing a form of p27 that is unable to bind or inhibit cyclin-CDK complexes (p27CK–) have increased incidence of tumor development as compared with wild-type and p27–/– mice, revealing an oncogenic role for p27. Here, we identified a phenotype of multinucleation and polyploidy in p27CK– mice not present in p27–/– animals, suggesting a role for p27 in G2/M that is independent of cyclin-CDK regulation. Further analysis revealed that p27CKȁ...
Source: Journal of Clinical Investigation - February 3, 2012 Category: Biomedical Science Authors: Murielle P. Serres, Uta Kossatz, Yong Chi, James M. Roberts, Nisar P. Malek, Arnaud Besson Source Type: research
PPAR{gamma} agonists enhance ET-743-induced adipogenic differentiation in a transgenic mouse model of myxoid round cell liposarcomaEmail this article to a colleague.
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Myxoid round cell liposarcoma (MRCLS) is a common liposarcoma subtype characterized by a translocation that results in the fusion protein TLS:CHOP as well as by mixed adipocytic histopathology. Both the etiology of MRCLS and the mechanism of action of TLS:CHOP remain poorly understood. It was previously shown that ET-743, an antitumor compound with an unclear mechanism of action, is highly effective in patients with MRCLS. To identify the cellular origin of MRCLS, we engineered a mouse model in which TLS:CHOP was expressed under the control of a mesodermally restricted promoter (Prx1) in a p53-depleted background. This mod...
Source: Journal of Clinical Investigation - February 3, 2012 Category: Biomedical Science Authors: Elizabeth Charytonowicz, Melissa Terry, Katherine Coakley, Leonid Telis, Fabrizio Remotti, Carlos Cordon-Cardo, Robert N. Taub, Igor Matushansky Source Type: research
Direct and efficient cellular transformation of primary rat mesenchymal precursor cells by KSHVEmail this article to a colleague.
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Infections by viruses are associated with approximately 12% of human cancer. Kaposi’s sarcoma-associated herpesvirus (KSHV) is causally linked to several malignancies commonly found in AIDS patients. The mechanism of KSHV-induced oncogenesis remains elusive, due in part to the lack of an adequate experimental system for cellular transformation of primary cells. Here, we report efficient infection and cellular transformation of primary rat embryonic metanephric mesenchymal precursor cells (MM cells) by KSHV. Cellular transformation occurred at as early as day 4 after infection and in nearly all infected cells. Trans...
Source: Journal of Clinical Investigation - February 3, 2012 Category: Biomedical Science Authors: Tiffany Jones, Fengchun Ye, Roble Bedolla, Yufei Huang, Jia Meng, Liwu Qian, Hongyi Pan, Fuchun Zhou, Rosalie Moody, Brent Wagner, Mazen Arar, Shou-Jiang Gao Source Type: research
Heparan sulfate sulfatase SULF2 regulates PDGFR{alpha} signaling and growth in human and mouse malignant gliomaEmail this article to a colleague.
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In this study, we demonstrated that the extracellular sulfatase, SULF2, an enzyme that regulates multiple HSPG-dependent RTK signaling pathways, was expressed in primary human GBM tumors and cell lines. Knockdown of SULF2 in human GBM cell lines and generation of gliomas from Sulf2–/– tumorigenic neurospheres resulted in decreased growth in vivo in mice. We found a striking SULF2 dependence in activity of PDGFRα, a major signaling pathway in GBM. Ablation of SULF2 resulted in decreased PDGFRα phosphorylation and decreased downstream MAPK signaling activity. Interestingly, in a survey of SULF...
Source: Journal of Clinical Investigation - February 3, 2012 Category: Biomedical Science Authors: Joanna J. Phillips, Emmanuelle Huillard, Aaron E. Robinson, Anna Ward, David H. Lum, Mei-Yin Polley, Steven D. Rosen, David H. Rowitch, Zena Werb Source Type: research
Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumorsEmail this article to a colleague.
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Appropriate localization and migration of T cells is a prerequisite for antitumor immune surveillance. Studies using fixed tumor samples from human patients have shown that T cells accumulate more efficiently in the stroma than in tumor islets, but the mechanisms by which this occurs are unknown. By combining immunostaining and real-time imaging in viable slices of human lung tumors, we revealed that the density and the orientation of the stromal extracellular matrix likely play key roles in controlling the migration of T cells. Active T cell motility, dependent on chemokines but not on β1 or β2 integrins, ...
Source: Journal of Clinical Investigation - February 3, 2012 Category: Biomedical Science Authors: Hélène Salmon, Katarzyna Franciszkiewicz, Diane Damotte, Marie-Caroline Dieu-Nosjean, Pierre Validire, Alain Trautmann, Fathia Mami-Chouaib, Emmanuel Donnadieu Source Type: research
A pseudokinase debut at the mycobacterial cell wall.Email this article to a colleague.
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Abstract
Mycobacterium tuberculosis, the causative agent of tuberculosis, has a complex cellular envelope that comprises both the cytoplasmic membrane and the outer cell wall. Despite advances in elucidating the structural and biochemical composition of these features, the processes that ensure cell wall homeostasis remain poorly understood. New findings implicate the essential mycobacterial serine-threonine protein kinase (STPK), PknB, in regulating the formation of a regulatory complex that includes the integral membrane protein MviN, which is required for peptidoglycan biosynthesis, and a forkhead-associated (FH...
Source: Science Signaling - February 3, 2012 Category: Biomedical Science Authors: Warner DF, Mizrahi V Tags: Sci Signal Source Type: research
Depletion of extracellular Ca2+ prompts astroglia to moderate synaptic network activity.Email this article to a colleague.
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Abstract
Over the past decade, rapid signal exchange between astroglia and neurons across the interstitial space emerged as an essential element of synaptic circuit functioning in the brain. How and where exactly this exchange occurs in various physiological scenarios and the underlying cellular cascades remain a subject of intense study. The excitatory neurotransmitter glutamate and the inhibitory neurotransmitter γ-aminobutyric acid are thought to be the primary signal carriers that are regularly dispatched by active synapses to engage target receptors and transporters on the surface of astrocytes. New evidence ...
Source: Science Signaling - February 3, 2012 Category: Biomedical Science Authors: Rusakov DA Tags: Sci Signal Source Type: research
A phosphorylated pseudokinase complex controls cell wall synthesis in mycobacteria.Email this article to a colleague.
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Abstract
Prokaryotic cell wall biosynthesis is coordinated with cell growth and division, but the mechanisms regulating this dynamic process remain obscure. Here, we describe a phosphorylation-dependent regulatory complex that controls peptidoglycan (PG) biosynthesis in Mycobacterium tuberculosis. We found that PknB, a PG-responsive Ser-Thr protein kinase (STPK), initiates complex assembly by phosphorylating a kinase-like domain in the essential PG biosynthetic protein, MviN. This domain was structurally diverged from active kinases and did not mediate phosphotransfer. Threonine phosphorylation of the pseudokinase ...
Source: Science Signaling - February 3, 2012 Category: Biomedical Science Authors: Gee CL, Papavinasasundaram KG, Blair SR, Baer CE, Falick AM, King DS, Griffin JE, Venghatakrishnan H, Zukauskas A, Wei JR, Dhiman RK, Crick DC, Rubin EJ, Sassetti CM, Alber T Tags: Sci Signal Source Type: research
Extracellular Ca2+ acts as a mediator of communication from neurons to glia.Email this article to a colleague.
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Abstract
Defining the pathways through which neurons and astrocytes communicate may contribute to the elucidation of higher central nervous system functions. We investigated the possibility that decreases in extracellular calcium ion concentration ([Ca(2+)](e)) that occur during synaptic transmission might mediate signaling from neurons to glia. Using noninvasive photolysis of the photolabile Ca(2+) buffer diazo-2 {N-[2-[2-[2-[bis(carboxymethyl)amino]-5-(diazoacetyl)phenoxy]ethoxy]-4-methylphenyl]-N-(carboxymethyl)-, tetrapotassium salt} to reduce [Ca(2+)](e) or caged glutamate to simulate glutamatergic transmissio...
Source: Science Signaling - February 3, 2012 Category: Biomedical Science Authors: Torres A, Wang F, Xu Q, Fujita T, Dobrowolski R, Willecke K, Takano T, Nedergaard M Tags: Sci Signal Source Type: research
Myosin I Links PIP3 Signaling to Remodeling of the Actin Cytoskeleton in Chemotaxis.Email this article to a colleague.
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Abstract
Class I myosins participate in various interactions between the cell membrane and the cytoskeleton. Several class I myosins preferentially bind to acidic phospholipids, such as phosphatidylserine and phosphatidylinositol 4,5-bisphosphate [PI(4,5)P(2)], through a tail homology 1 (TH1) domain. Here, we show that the second messenger lipid phosphatidylinositol 3,4,5-trisphosphate (PIP(3)) binds to the TH1 domain of a subset of Dictyostelium class I myosins (ID, IE, and IF) and recruits them to the plasma membrane. The PIP(3)-regulated membrane recruitment of myosin I promoted chemotaxis and induced chemoattra...
Source: Science Signaling - February 3, 2012 Category: Biomedical Science Authors: Chen CL, Wang Y, Sesaki H, Iijima M Tags: Sci Signal Source Type: research
PAS Kinase Promotes Cell Survival and Growth Through Activation of Rho1.Email this article to a colleague.
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Abstract
In Saccharomyces cerevisiae, phosphorylation of Ugp1 by either of the yeast PASK family protein kinases (yPASK), Psk1 or Psk2, directs this metabolic enzyme to deliver glucose to the periphery for synthesis of the cell wall. However, we isolated PSK1 and PSK2 in a high-copy suppressor screen of a temperature-sensitive mutant of target of rapamycin 2 (TOR2). Posttranslational activation of yPASK, either by cell integrity stress or by growth on nonfermentative carbon sources, also suppressed the growth defect resulting from tor2 mutation. Although suppression of the tor2 mutant growth phenotype by activation...
Source: Science Signaling - February 3, 2012 Category: Biomedical Science Authors: Cardon CM, Beck T, Hall MN, Rutter J Tags: Sci Signal Source Type: research
Black holes: Giving life as well as dealing deathEmail this article to a colleague.
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Astrophysicists have identified a black hole that appears to be helping new stars to form amongst its encircling gas clouds - News (Source: Imperial College News)
Source: Imperial College News - February 3, 2012 Category: Biomedical Science Source Type: news
Surface of Mars an unlikely place for life after 600 million year drought, sayEmail this article to a colleague.
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New study suggests super-drought made it too hostile for any life survive on the Mars' surface - News Release (Source: Imperial College News)
Source: Imperial College News - February 3, 2012 Category: Biomedical Science Source Type: news
Thymic stromal lymphopoietin: an immune cytokine gene associated with the metabolic syndrome and blood pressure in severe obesityEmail this article to a colleague.
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A previous expression profiling of visceral adipose tissue (VAT) revealed that the thymic stromal lymphopoietin (TSLP) gene was less expressed in severely obese men with (n=7) vs. without (n=7) the metabolic syndrome (MS). We hypothesized that TSLP single nucleotide polymorphisms (SNPs) are associated with TSLP gene expression in VAT and with MS phenotypes. Following validation of lower TSLP expression (p=0.003) in VAT of severely obese men and women with (n=70) vs. without (n=60) MS, a detailed genetic investigation was performed at the TSLP locus by sequencing its promoter, exons and intron-exon splicing boundaries using...
Source: Clinical Science - February 3, 2012 Category: Biomedical Science Authors: V Turcot, L Bouchard, G Faucher, V Garneau, A Tchernof, Y Deshaies, L Pérusse, S Marceau, S Biron, O Lescelleur, L Biertho, M Vohl Source Type: research
Single-mRNA counting using fluorescent in situ hybridization in budding yeastEmail this article to a colleague.
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Robert H Singer
Fluorescent in situ hybridization (FISH) allows the quantification of single mRNAs in budding yeast using fluorescently labeled single-stranded DNA probes, a wide-field epifluorescence microscope and a spot-detection algorithm. Fixed yeast cells are attached to coverslips and hybridized with a mixture of FISH probes, each (Source: Nature Protocols)
Source: Nature Protocols - February 2, 2012 Category: Biomedical Science Authors: Tatjana TrcekJeffrey A ChaoDaniel R LarsonHye Yoon ParkDaniel ZenklusenShailesh M ShenoyRobert H Singer Tags: Protocol Source Type: research
Improved biocytin labeling and neuronal 3D reconstructionEmail this article to a colleague.
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In this report, we describe a reliable protocol for biocytin labeling of neuronal tissue and diaminobenzidine (DAB)-based processing of brain slices. We describe how to embed tissues in different media and how to subsequently histochemically label the tissues for light or electron microscopic examination. We (Source: Nature Protocols)
Source: Nature Protocols - February 2, 2012 Category: Biomedical Science Authors: Manuel MarxRobert H GünterWerner HuckoGabriele RadnikowDirk Feldmeyer Tags: Protocol Source Type: research
A pipeline for the generation of shRNA transgenic miceEmail this article to a colleague.
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non & Scott W Lowe
RNA interference (RNAi) is an extremely effective tool for studying gene function in almost all metazoan and eukaryotic model systems. RNAi in mice, through the expression of short hairpin RNAs (shRNAs), offers something not easily achieved with traditional genetic approaches—inducible and reversible gene silencing. However, (Source: Nature Protocols)
Source: Nature Protocols - February 2, 2012 Category: Biomedical Science Authors: Lukas E DowPrem K PremsrirutJohannes ZuberChristof FellmannKatherine McJunkinCornelius MiethingYoungkyu ParkRoss A DickinsGregory J HannonScott W Lowe Tags: Protocol Source Type: research
Expression of high-affinity human antibody fragments in bacteriaEmail this article to a colleague.
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This article provides an overview of expression and purification (Source: Nature Protocols)
Source: Nature Protocols - February 2, 2012 Category: Biomedical Science Authors: Romain RouetDavid LoweKip DudgeonBrendan RoomePeter SchofieldDavid LangleyJohn AndrewsPeter WhitfeldLutz JermutusDaniel Christ Tags: Protocol Source Type: research
Mathematical modeling of solid cancer growth with angiogenesisEmail this article to a colleague.
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Conclusions:
Cancer can be settled in an organ if the following combination matches: better fitness of cancercells, decrease in the effciency of the repairing systems, increase in the capacity of sprouting from existingvascularization, and higher capacity of mounting up new vascularization. However, we show that cancer is rarelyinduced in organs (or tissues) displaying an efficient (numerically and functionally) reparative or regenerativemechanism. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - February 2, 2012 Category: Biomedical Science Authors: Hyun Yang Source Type: research
A molecular diffusion based utility model for Drosophila larval phototaxisEmail this article to a colleague.
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Conclusions:
Our model provides new insights into decision making mechanisms in general. From an engineering viewpoint, we propose that the model could be applied to a wider range of decision making practices. (Source: Theoretical Biology and Medical Modelling)
Source: Theoretical Biology and Medical Modelling - February 2, 2012 Category: Biomedical Science Authors: Zhejun GongZhefeng Gong Source Type: research
Review of HPLC methods and HPLC methods with mass spectrometric detection for direct determination of aspirin with its metabolite(s) in various biological matrices.Email this article to a colleague.
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Abstract
Aspirin, the most widely used drug in the world, has been known to mankind for over a century. It is not only the pharmacologically active entity, but is also biotransformed into a major metabolite, i.e. salicylic acid, which also exhibits similar pharmacologic/pharmacodynamic properties. Hence it is necessary to quantitate aspirin along with its metabolite(s) in various biological matrices accurately and precisely to correlate with pharmacological/pharmacodynamic activity. This paper provides a comprehensive overview of various bioanalytical methods (HPLC and LC-MS/MS) that have been reported for direct q...
Source: Biomedical Chromatography : BMC - February 2, 2012 Category: Biomedical Science Authors: Mullangi R, Sharma K, Srinivas NR Tags: Biomed Chromatogr Source Type: research
Comprehensive chemical profiling of Guizhi Fuling capsule by the combined use of gas chromatography-mass spectrometry with a deconvolution software and rapid-resolution liquid chromatography quadrupole time-of-flight tandem mass spectrometry.Email this article to a colleague.
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In this study, an analytical strategy combining two approaches was established for comprehensive analysis of herbal formulations. Guizhi Fuling capsule (GFC), a drug approved by the FDA to enter phase II clinical trial for treatment of primary dysmenorrhea, was taken as a case for analysis. Gas chromatography-mass spectrometry (GC-MS) with automated mass spectral deconvolution and identification system (AMDIS) led to rapid identification of 48 volatile components including four acetophenones, three fatty acid esters, 13 phenylpropanoids and 19 sesquiterpenes. Most of them were found from Guizhi. The volatile oils of Guizhi...
Source: Biomedical Chromatography : BMC - February 2, 2012 Category: Biomedical Science Authors: Wang YQ, Qi LW, Aa J, Wang GJ, Gao W, Cheng SJ, Wang ZZ, Xiao W, Li P Tags: Biomed Chromatogr Source Type: research
Smart-e-Pants aim to eliminate bed soresEmail this article to a colleague.
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Gem Hebert is not shy about bearing her backside for medical science. She's one of about two dozen Alberta patients helping test a new technology called Smart-e-Pants, a custom electric underwear aiming to prevent bed sores. (Source: CTV Health)
Source: CTV Health - February 1, 2012 Category: Consumer Health News Source Type: news
Children test the air for pollutants in Brighton science projectEmail this article to a colleague.
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Imperial scientists gather air pollution data with the help of Brighton school children - News (Source: Imperial College News)
Source: Imperial College News - February 1, 2012 Category: Biomedical Science Source Type: news
Med Sci Monit 2012; 18(2):PR1-3 "A69S and R38X ARMS2 and Y402H CFH gene polymorphisms as risk factors for neovascular age-related macular degeneration in Poland – a brief report"Email this article to a colleague.
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Conclusions: The etiologic role in ARMD of A69S ARMS2 and Y402H CFH gene variants were confirmed in a Polish population for the first time. R38X variant of ARMS2 seems to be protective from wet ARMD. (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 1, 2012 Category: Research Source Type: research
Med Sci Monit 2012; 18(2):PI5-9 "The application of Levulan®-based photodynamic therapy with imiquimod in the treatment of recurrent basal cell carcinoma"Email this article to a colleague.
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Conclusions: Cure was achieved without any scarring and with very good cosmetic effects. Although this is the preliminary report, the presented modification of PDT seems to be reasonable and promising in treating basal-cell carcinoma. (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 1, 2012 Category: Research Tags: Original article Source Type: research
Med Sci Monit 2012; 18(2):PH12-17 "The temporal relationship between RotaTeq immunization and intussusception adverse events in the Vaccine Adverse Event Reporting System (VAERS)"Email this article to a colleague.
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Conclusions: The present study significantly associates RotaTeq vaccination with intussusception AEs. (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 1, 2012 Category: Research Tags: Original article Source Type: research
Med Sci Monit 2012; 18(2):PH6-11 "How well do anthropometric indices correlate with cardiovascular risk factors? A cross-sectional study in Croati"Email this article to a colleague.
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Conclusions: Results encourage the use of BMI and WtHR as important tools in predicting CV risk in GP’s practice. (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 1, 2012 Category: Research Tags: Original article Source Type: research
Med Sci Monit 2012; 18(2):PH1-5 "Prevalence of metabolic syndrome in elderly Japanese-Brazilians"Email this article to a colleague.
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Conclusions: Elderly Japanese-Brazilians present high metabolic syndrome prevalence independent of waist circumference cutoff values. Concordance between the 3 definitions is high, suggesting that all 3 cutoff values yield similar metabolic syndrome prevalence values in this population. (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 1, 2012 Category: Research Source Type: research
Med Sci Monit 2012; 18(2):MT7-18 "Safety of embolic protection device-assisted and unprotected intravascular ultrasound in evaluating carotid artery atherosclerotic lesions"Email this article to a colleague.
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Conclusions: Carotid IVUS is safe and, for the less severe lesions in particular, it may not require mandatory EPD use. High-risk lesions can be safely evaluated with IVUS under flow reversal/blockade. (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 1, 2012 Category: Research Tags: Original article Source Type: research
Med Sci Monit 2012; 18(2):CS12-15 "A case of bilateral persistent sciatic artery with unilateral aneurysm: An 18-year period of graft patency after excision of aneurysm"Email this article to a colleague.
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Conclusions: To our knowledge the follow-up of the presented case is the longest reported so far in the literature. The uneventful course of the patient confirms that classical aneurysmectomy still constitutes one of the treatment options of PSA aneurysm. (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 1, 2012 Category: Research Tags: Case report Source Type: research
Med Sci Monit 2012; 18(2):CS8-11 "Massive bleeeding from upper gastrointestinal tract as a symptom of rupture of splenic artery aneurysm to stomach"Email this article to a colleague.
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Conclusions: The case described confirms that splenic artery aneurysm can be a cause of bleeding to both upper and lower parts of the gastrointestinal tract, and the aneurysm rupture is usually of a dramatic and life-threatening course. (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 1, 2012 Category: Research Tags: Case report Source Type: research
Med Sci Monit 2012; 18(2):CS5-7 "Mirror, mirror on the wall: Hypercalcemia as a consequence of modern cosmetic treatment with liquid silicone"Email this article to a colleague.
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Conclusions: In rare cases, symptomatic hypercalcemia can be caused by silicone due to a severe granulomatous tissue reaction. This is the first time that a transdermal silicone treatment has been reported to cause severe granulomatous tissue inflammation. (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 1, 2012 Category: Research Tags: Case report Source Type: research
Med Sci Monit 2012; 18(2):CR125-130 "Inhibitory effects of intravenous lansoprazole 30 mg and pantoprazole 40 mg twice daily on intragastric acidity in healthy Chinese volunteers: A randomized, open-labeled, two-way crossover study"Email this article to a colleague.
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Conclusions: Intravenous lansoprazole produces a longer and more potent inhibitory effect on intragastric acidity than does intravenous pantoprazole. (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 1, 2012 Category: Research Tags: Original article Source Type: research
Med Sci Monit 2012; 18(2):CR119-124 "Self-esteem and styles of coping with stress versus strategies of planning in people with psychopathic personality disorders"Email this article to a colleague.
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Conclusions: The hypothesis was confirmed, that people with psychopathic personality disorders are characterised by high self-esteem, unconstructive strategies of planning actions and non-adaptive styles of coping with stress. (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 1, 2012 Category: Research Source Type: research
Med Sci Monit 2012; 18(2):CR112-118 "Head and neck cancer: Value of perfusion CT in depicting primary tumor spread"Email this article to a colleague.
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Conclusions: CTP shows promise in depicting malignant infiltration. The combined use of CECT plus CTP results in correct staging of the majority of head and neck tumors. (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 1, 2012 Category: Research Tags: Original article Source Type: research
Med Sci Monit 2012; 18(2):CR105-111 "The influence of heparin resistance on postoperative complications in patients undergoing coronary surgery"Email this article to a colleague.
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Conclusions: Mild forms of heparin resistance are relatively frequent and are not associated with increased morbidity and mortality. The isolation of severe heparin resistance as an independent predictor of death in our large cohort of coronary patients suggests that this phenomenon should be given more attention in future studies. (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 1, 2012 Category: Research Tags: Original article Source Type: research
Med Sci Monit 2012; 18(2):CR93-104 "Dentigenous infectious foci – a risk factor of infective endocarditis"Email this article to a colleague.
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Conclusions: Among various dentigenous, infectious foci, the intradental foci appear to constitute a risk factor for infective endocarditis. (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 1, 2012 Category: Research Tags: Original article Source Type: research
Med Sci Monit 2012; 18(2):CR88-92 "Thermal ablation of unresectable liver tumors: Factors associated with partial ablation and the impact on long-term survival"Email this article to a colleague.
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Conclusions: We conclude that achievement of complete ablation is a highly important predictor of long-term survival and that tumor size is by far the most important predictor of the likelihood of achieving complete ablation. (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 1, 2012 Category: Research Tags: Original article Source Type: research
Med Sci Monit 2012; 18(2):CR78-87 "Relation of hs-CRP and BNP levels with the atrial spontaneous echo contrast and thrombi in permanent atrial fibrillation patients with different etiologies"Email this article to a colleague.
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Conclusions: Higher hs-CRP levels in AF patients may be a predictor for the presence of SEC and thrombi in the atria. (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 1, 2012 Category: Research Tags: Original article Source Type: research
Med Sci Monit 2012; 18(2):CR72-77 "Persistence of initial oral antidiabetic treatment in patients with type 2 diabetes mellitus"Email this article to a colleague.
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Conclusions: The persistence of initial treatment with metformin and/or sulphonylureas is far from optimal. Better diabetic care and continuous patient education should be encouraged to achieve higher persistence of oral antidiabetic treatment in patients with type 2 diabetes. (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 1, 2012 Category: Research Tags: Original article Source Type: research
Med Sci Monit 2012; 18(2):CR65-71 "Sex-specific association of anthropometric measures of body composition with arterial stiffness in a healthy population"Email this article to a colleague.
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Conclusions: Measures of body composition are weak and inverse predictors of arterial stiffness and their influence is sex-dependent. BMI, WC and WHtR were key predictors of arterial stiffness in the females, while BMI was the principal predictor in the males. The associations of anthropometric measures with arterial stiffness are strongly and differently confounded by various factors that have to be taken into account when explaining results of similar studies. (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 1, 2012 Category: Research Tags: Original article Source Type: research
Med Sci Monit 2012; 18(2):CR58-64 "Periodontal microcirculation in diabetics: An in vivo non-invasive analysis by means of videocapillaroscopy"Email this article to a colleague.
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Conclusions: The increase in capillary density could suggest the presence of active inflammatory phenomena or, more probably, a tendency to a greater susceptibility to inflammatory phenomena. Ultimately, this study shows that there is some peripheral damage to microcirculation at the masticatory mucous level in diabetic subjects and that such alterations can be instrumentally objectified and quantified through the videocapillaroscopic method. (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 1, 2012 Category: Research Tags: Original article Source Type: research
Med Sci Monit 2012; 18(2):CR51-57 "Indocyanine green angiography in chronic central serous chorioretinopathy"Email this article to a colleague.
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Conclusions: ICGA is a very useful examination that enables ophthalmologists to visualize choroidal changes due to chronic CSC, as well as to diagnose occult CNV in chronic CSC. (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 1, 2012 Category: Research Tags: Original article Source Type: research
Med Sci Monit 2012; 18(2):CQ1-3 "Postcardiac injury syndrome. Part II"Email this article to a colleague.
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A 58-year-old man had undergone 2-vessel off-pump coronary artery bypass surgery (OPCAB), 1 month before he was admitted into the hospital with cardiac tamponade due to pericarditis. Postcardiac injury syndrome (PCIS) was diagnosed. In spite of receiving anti-inflammatory treatment, the patient developed relapsing PCIS. (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 1, 2012 Category: Research Source Type: research
Med Sci Monit 2012; 18(2):BR84-88 "Lack of association of conjunctival MALT lymphoma with Chlamydiae or Helicobacter pylori in a cohort of Chinese patients"Email this article to a colleague.
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Conclusions: The PCR technique was able to detect the positive control quickly and accurately, but the results of PCR in analyzing the 16 specimens were negative, indicating that there is no association between conjunctival MALT lymphoma and the 4 microorganisms in Chinese patients. (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 1, 2012 Category: Research Tags: Original article Source Type: research
Med Sci Monit 2012; 18(2):BR76-83 "Changes in chemiluminescence of whole blood of COPD patients treated with Hypoxen® and effects of C60 fullerenes on blood chemiluminescence"Email this article to a colleague.
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Conclusions: Monitoring of CL of non-diluted whole blood in COPD patients can be used for the estimation of the Hypoxen® efficiency in complex therapy. Addition of HyFnC60 to blood increases sensitivity of the method. (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 1, 2012 Category: Research Tags: Original article Source Type: research
Med Sci Monit 2012; 18(2):BR69-75 "Determination of PKC isoform-specific protein expression in pulmonary arteries of rats with chronic hypoxia-induced pulmonary hypertension"Email this article to a colleague.
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Conclusions: This study is the first systematic analysis of PKC isoform-specific membrane translocation and protein expression in pulmonary arteries, suggesting that the changes in membrane translocation and protein expression of cPKCalpha, betaI, betaII and nPKCdelta are involved in the development of hypoxia-induced rat PH. (Source: Medical Science Monitor)
Source: Medical Science Monitor - February 1, 2012 Category: Research Tags: Original article Source Type: research
Not Scarred For LifeEmail this article to a colleague.
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Biomedical Science: Researchers use small molecules to coax muscle cells into reverting to stemlike cells with hopes of scar-free wound healing (Source: Chemical and Engineering News)
Source: Chemical and Engineering News - January 31, 2012 Category: Chemistry Authors: Erika Gebel Source Type: research
