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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 22.

Zonal rate model for axial and radial flow membrane chromatography. Part I: Knowledge transfer across operating conditions and scales
Abstract The zonal rate model (ZRM) has previously been applied for analyzing the performance of axial flow membrane chromatography capsules by independently determining the impacts of flow and binding related non‐idealities on measured breakthrough curves. In the present study, the ZRM is extended to radial flow configurations, which are commonly used at larger scales. The axial flow XT5 capsule and the radial flow XT140 capsule from Pall are rigorously analyzed under binding and non‐binding conditions with bovine serum albumin (BSA) as test molecule. The binding data of this molecule is much better reproduced by the ...
Source: Biotechnology and Bioengineering - November 23, 2012 Category: Biomedical Science Authors: Pranay Ghosh, Kaveh Vahedipour, Min Lin, Jens H. Vogel, Charles A. Haynes, Eric von Lieres Tags: Article Source Type: research

IL‐17F co‐ ;expression improves cell growth characteristics and enhances recombinant protein production during CHO cell line engineering
This study demonstrates that IL‐17F expression in CHO cells confers benefit during cell line engineering for recombinant protein production. Aside from enhanced cell line productivity, improvements in cell growth during selection and subcloning allowed for an overall time saving of up to one month during clonal cell line selection.
Source: Biotechnology and Bioengineering - November 23, 2012 Category: Biomedical Science Authors: Mathias Contie, Olivier Leger, Nicolas Fouque, Yves Poitevin, Marie Kosco‐Vilbois, Nicolas Mermod, Greg Elson Tags: Article Source Type: research

Stimulation and Inhibition of Neurons
series:NeuromethodsActivation, inhibition, or destruction of the nervous system or its component parts as a vital tool for the investigation of function has undergone remarkable development; indeed, new approaches have been developed that allow for these actions to be used as therapeutic tools. In Stimulation and Inhibition of Neurons, experts in the field provide an overview of modern methods for generating ...
Source: Springer Biomedical Sciences titles - November 22, 2012 Category: Biomedical Science Tags: Neurosciences Source Type: news

Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology
series:Advances in Experimental Medicine and BiologySince its first description fifteen years ago as a novel antigen of neural and hematopoietic stem cells, prominin-1 (alias CD133) has emerged concomitantly with stem and cancer stem cell research as an essential cell surface marker allowing identification and isolation of cells with stem cell properties. Although the physiological function of prominin-1 and the other members of prominin family ...
Source: Springer Biomedical Sciences titles - November 22, 2012 Category: Biomedical Science Tags: Cancer Research Source Type: news

DNA Helicases and DNA Motor Proteins
series:Advances in Experimental Medicine and BiologyIn recent years, a number of groundbreaking structural and mechanistic studies deepened our understanding of helicase mechanisms and established new approaches for their analyses. Many fundamental mechanistic questions ranging from the mechanism of force generation, mechanochemical coupling to distinct mechanisms by which the same enzyme translocates on DNA removing obstacles, unwinds DNA ...
Source: Springer Biomedical Sciences titles - November 22, 2012 Category: Biomedical Science Tags: Human Genetics Source Type: news

Fixing the economy, with Science!
Former Apprentice candidate Katie Hopkins has offered solutions to the problems with the NHS. So it's only fair that someone with biomedical science knowledge offers solutions for how to fix the problems with the economy.SpotOn London 2012 took place recently. For those unaware, it's a conference focussing on "how science is carried out and communicated online". Many interesting points were brought up during it, one of which was the issue of self-promotion. The extent to which you should self-promote, and how people will react to this, resulted in a number of interesting discussions. Athene Donald, on her excellent blog, a...
Source: Guardian Unlimited Science - November 22, 2012 Category: Science Authors: Dean Burnett Tags: Psychology Blogposts Economic growth (GDP) guardian.co.uk Celebrity Science Source Type: news

Cellular Trafficking of Cell Stress Proteins in Health and Disease
series:Heat Shock ProteinsSince the beginning of the 21st Century there has been a rapid increase in our understanding of the cellular trafficking mechanisms of molecular chaperones in eukaryotes and in prokaryotes. In the former, molecular chaperone trafficking can occur between the various cellular compartments, with concomitant movement of other proteins. Such events can also result in the release of molecular ...
Source: Springer Biomedical Sciences titles - November 22, 2012 Category: Biomedical Science Tags: Human Physiology Source Type: news

In vivo measurement of ACL length and relative strain during walking
Abstract: Although numerous studies have addressed the effects of ACL injury and reconstruction on knee joint motion, there is currently little data available describing in vivo ACL strain during activities of daily living. Data describing in vivo ACL strain during activities such as gait is critical to understanding the biomechanical function of the ligament, and ultimately, to improving the surgical treatment of patients with ACL rupture. Thus, our objective was to characterize the relative strain in the ACL during both the stance and swing phases of normal level walking. Eight normal subjects were recruited for this stu...
Source: Journal of Biomechanics - November 22, 2012 Category: Biomedical Science Authors: K.A. Taylor, H.C. Cutcliffe, R.M. Queen, G.M. Utturkar, C.E. Spritzer, W.E. Garrett, L.E. DeFrate Tags: Papers Source Type: research

Etiology of recurrent acute pancreatitis, with special emphasis on pancreaticobiliary malformation.
Conclusion: Pancreaticobiliary malformation is one of the major causes of RAP. As some of them benefit from endoscopic or surgical treatment, morphology of the pancreaticobiliary duct system should be examined where possible in RAP patients. PMID: 23183766 [PubMed - as supplied by publisher]
Source: Advances in Medical Sciences - November 22, 2012 Category: Biomedical Science Authors: Takuma K, Kamisawa T, Hara S, Tabata T, Kuruma S, Chiba K, Kuwata G, Fujiwara T, Egashira H, K K, Fujiwara J, Arakawa T, Momma K, Igarashi Y Tags: Adv Med Sci Source Type: research

Ethanolic extract of propolis, chrysin, Cape inhibit human astroglia cells.
Conclusion: This study showed that EEP, chrysin and CAPE reduced viability of human astroglia cells probably due to apoptosis process. PMID: 23183767 [PubMed - as supplied by publisher]
Source: Advances in Medical Sciences - November 22, 2012 Category: Biomedical Science Authors: Markiewicz-Żukowska R, Car H, Naliwajko S, Sawicka D, Szynaka B, Chyczewski L, Isidorov V, Borawska M Tags: Adv Med Sci Source Type: research

Vitamin D analogs decrease in vitro secretion of RANTES and enhance the effect of budesonide.
Conclusion: Active VD compounds via downregulation of RANTES production exert a potential role as a complementary element in the therapy of chronic rhinosinusitis with NP. Compounds consisting of budesonide and VD derivate have an advantage over both drugs used in monotherapy. PMID: 23183768 [PubMed - as supplied by publisher]
Source: Advances in Medical Sciences - November 22, 2012 Category: Biomedical Science Authors: Fraczek M, Rostkowska-Nadolska B, Kusmierz D, Zielinska A, Rok J, Sliupkas-Dyrda E, Grzanka A, Krecicki T, Latocha M Tags: Adv Med Sci Source Type: research

Calcium influx through the TRPV1 channel of endothelial cells (ECs) correlates with a stronger adhesion between monocytes and ECs.
Conclusion: These results suggest that an inward calcium current via the TRPV1 channels of endothelial cells correlates with a stronger adhesion between monocytes and endothelial cells. PMID: 23183769 [PubMed - as supplied by publisher]
Source: Advances in Medical Sciences - November 22, 2012 Category: Biomedical Science Authors: Himi N, Hamaguchi A, Hashimoto K, Koga T, Narita K, Miyamoto O Tags: Adv Med Sci Source Type: research

How Doppler effect occurs in absence of intracranial blood flow in brain death?
Lack of intracranial arterial and venous circulation (cerebral circulatory arrest) is major confirmatory criterion of brain death diagnosis. Circulatory arrest can be demonstrated by angiography, single photon emission computed tomography or transcranial Doppler ultrasound (TCD). TCD is more practical mainly due to its bed-side applicability . TCD sonogram patterns compatible with brain death are to-and-fro pattern (TaFP, complete diastolic flow reversal), systolic spikes (SS) and flow absence within internal carotid arteries (ICA) and vertebral arteries, bilaterally . Flow absence cannot be used for confirmation unless th...
Source: Medical Hypotheses - November 22, 2012 Category: Biomedical Science Authors: Mehmet Akif Topcuoglu, Ethem Murat Arsava Tags: Correspondence Source Type: research

Tumor-derived microvesicles: The metastasomes
Abstract: Metastasis is the leading cause of cancer death, yet it is mechanistically considered a very inefficient process suggesting the presence of some sort of (e.g. systemic) routes for fuelling the process. The pre-metastatic niche formation is described as one such metastasis promoting route. Now, the emerging potentials of tumor-derived microvesicles (TDMVs), not only in formulating the pre-metastatic niche, but also conferring neoplastic phenotypes onto normal cells, has integrated new concepts into the field. Here, we note as an ancillary proposition that, exerting functional disturbances in other sites, TDMVs (we...
Source: Medical Hypotheses - November 22, 2012 Category: Biomedical Science Authors: Reza Ghasemi, Antonino Grassadonia, Nicola Tinari, Enza Piccolo, Clara Natoli, Federica Tomao, Stefano Iacobelli Tags: Articles Source Type: research

Editorial Board
Source: Metabolism - Clinical and Experimental - November 21, 2012 Category: Biomedical Science Tags: Frontmatter Source Type: research

Table of Contents
Source: Metabolism - Clinical and Experimental - November 21, 2012 Category: Biomedical Science Tags: Frontmatter Source Type: research

Masthead
Source: Metabolism - Clinical and Experimental - November 21, 2012 Category: Biomedical Science Source Type: research

Integrating cell‐free biosyntheses of heme prosthetic group and apoenzyme for the synthesis of functional P450 monooxygenase
Abstract Harnessing the isolated protein synthesis machinery, cell‐free protein synthesis reproduces the cellular process of decoding genetic information in artificially controlled environments. More often than not, however, generation of functional proteins requires more than simple translation of genetic sequences. For instance, many of the industrially important enzymes require non‐protein prosthetic groups for biological activity. Herein, we report the complete cell‐free biogenesis of a heme prosthetic group and its integration with concurrent apoenzyme synthesis for the production of functional P450 monooxygenas...
Source: Biotechnology and Bioengineering - November 21, 2012 Category: Biomedical Science Authors: Yong‐Chan Kwon, In‐Seok Oh, Nahum Lee, Kyung‐Ho Lee, Yeo Joon Yoon, Eun Yeol Lee, Byung‐Gee Kim, Dong‐Myung Kim Tags: Article Source Type: research

Cell 151: 1126-1137 (11-21-12)
Cell 151: 1126-1137 Molecular profiling of activated neurons by phosphorylated ribosome capture Zachary A. Knight, Keith Tan, Kivanc Birsoy, Sarah Schmidt, Jennifer L. Garrison, Robert W. Wysocki, Ana Emiliano, Mats I. Ekstrand and Jeffrey M. Friedman
Source: The Rockefeller University Newswire - November 21, 2012 Category: Biomedical Science Authors: pubaff Tags: Research Update Source Type: news

Cell 151: 1005-1016 (11-21-12)
Cell 151: 1005-1016 Promoter-specific transcription inhibition in Staphylococcus aureus by a phage protein Joseph Osmundson, Cristina Montero-Diez, Lars F. Westblade, Ann Hochschild and Seth A. Darst
Source: The Rockefeller University Newswire - November 21, 2012 Category: Biomedical Science Authors: pubaff Tags: Research Update Source Type: news

Neuron 76: 735-749 (11-21-12)
Neuron 76: 735-749 14-3-3 proteins regulate a cell-intrinsic switch from sonic hedgehog-mediated commissural axon attraction to repulsion after midline crossing Patricia T. Yam, Christopher B. Kent, Steves Morin, W. Todd Farmer, Ricardo Alchini, Léa Lepelletier, David R. Colman, Marc Tessier-Lavigne, … More »
Source: The Rockefeller University Newswire - November 21, 2012 Category: Biomedical Science Authors: pubaff Tags: Research Update Source Type: news

Cell 151: 1068-1082 (11-21-12)
Cell 151: 1068-1082 Convergent multi-miRNA targeting of ApoE drives LRP1/LRP8-dependent melanoma metastasis and angiogenesis Nora Pencheva, Hien Tran, Colin Buss, Doowon Huh, Marija Drobnjak, Klaus Busam and Sohail F. Tavazoie
Source: The Rockefeller University Newswire - November 21, 2012 Category: Biomedical Science Authors: pubaff Tags: Research Update Source Type: news

Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology
series:Advances in Experimental Medicine and BiologySince its first description fifteen years ago as a novel antigen of neural and hematopoietic stem cells, prominin-1 (alias CD133) has emerged concomitantly with stem and cancer stem cell research as an essential cell surface marker allowing identification and isolation of cells with stem cell properties. Although the physiological function of prominin-1 and the other members of prominin family ...
Source: Springer Biomedical Sciences titles - November 21, 2012 Category: Biomedical Science Tags: Cancer Research Source Type: news

DNA Helicases and DNA Motor Proteins
series:Advances in Experimental Medicine and BiologyIn recent years, a number of groundbreaking structural and mechanistic studies deepened our understanding of helicase mechanisms and established new approaches for their analyses. Many fundamental mechanistic questions ranging from the mechanism of force generation, mechanochemical coupling to distinct mechanisms by which the same enzyme translocates on DNA removing obstacles, unwinds DNA ...
Source: Springer Biomedical Sciences titles - November 21, 2012 Category: Biomedical Science Tags: Human Genetics Source Type: news

Stimulation and Inhibition of Neurons
series:NeuromethodsActivation, inhibition, or destruction of the nervous system or its component parts as a vital tool for the investigation of function has undergone remarkable development; indeed, new approaches have been developed that allow for these actions to be used as therapeutic tools. In Stimulation and Inhibition of Neurons, experts in the field provide an overview of modern methods for generating ...
Source: Springer Biomedical Sciences titles - November 21, 2012 Category: Biomedical Science Tags: Neurosciences Source Type: news

GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity
series:Subcellular BiochemistryThis book provides a broad survey of various topics pertaining to G protein coupled receptor (GPCR) assembly into specific signalling complexes, and the regulation of the events leading to this assembly. Throughout this book, we focus on one main area: GPCRs are involved in highly efficient and specific activation of signalling pathways; how are these signalling complexes assembled to generate ...
Source: Springer Biomedical Sciences titles - November 21, 2012 Category: Biomedical Science Tags: Biomedicine (general) Source Type: news

Evaluation of microextraction by packed sorbent and micro-liquid chromatography-tandem mass spectrometry as a green approach in bioanalysis.
In this study the use of micro-liquid chromatography coupled to tandem mass spectrometry (μLC-MS/MS) was investigated in routine bioanalysis application for separation and quantification of pro-drug AZD6319 (developed for aldezheimer treatment). Microextraction by packed sorbent (MEPS) was used as sample clean-up method. The focus of this study was put on the evaluation of the usability of smaller column diameters such as 1.0 and 0.3 mm instead of 2.1 mm in bioanalysis application to reduce solvent consumption and sample volumes. Solvent consumption was reduced by 80% when a 1.0 mm column was used compared with 2.1�...
Source: Biomedical Chromatography : BMC - November 21, 2012 Category: Biomedical Science Authors: Abdel-Rehim A, Abdel-Rehim M Tags: Biomed Chromatogr Source Type: research

Steady flow through a constricted cylinder by multiparticle collision dynamics.
Abstract The flow characterization of blood through healthy and diseased flow geometries is of interest to researchers and clinicians alike, as it may allow for early detection, and monitoring, of cardiovascular disease. In this paper, we use a numerically efficient particle-based flow model called multiparticle collision dynamics (MPC for short) to study the effect of compressibility and slip of flow of a Newtonian fluid through a cylinder with a local constriction. We use a cumulative averaging method to compare our MPC results to the finite-element solution of the incompressible no-slip Navier-Stokes equations i...
Source: Biomechanics and Modeling in Mechanobiology - November 21, 2012 Category: Biomedical Science Authors: Bedkihal S, Kumaradas JC, Rohlf K Tags: Biomech Model Mechanobiol Source Type: research

Comparison of partial least squares regression and principal component regression for pelvic shape prediction
Abstract: This paper studied two different regression techniques for pelvic shape prediction, i.e., the partial least square regression (PLSR) and the principal component regression (PCR). Three different predictors such as surface landmarks, morphological parameters, or surface models of neighboring structures were used in a cross-validation study to predict the pelvic shape. Results obtained from applying these two different regression techniques were compared to the population mean model. In almost all the prediction experiments, both regression techniques unanimously generated better results than the population mean mo...
Source: Journal of Biomechanics - November 21, 2012 Category: Biomedical Science Authors: Steffen Schumann, Lutz-P. Nolte, Guoyan Zheng Tags: Short Communications Source Type: research

The potential of iodine for improving breast cancer diagnosis and treatment
Abstract: Early detection through modalities such as mammography remains pivotal in the fight against breast cancer. The detectability of breast cancer through mammography is rooted in the differential X-ray attenuation properties of cancerous and normal breast tissue. An unexplored component of the X-ray contrast between fibrous breast tissue and similarly composed tumor tissue is the presence of naturally localized iodine in the cancer but not healthy breast tissue. It is hypothesized that differing amounts of iodine are present in tumor versus normal breast tissue that leads to more easily detectable cancer due to an in...
Source: Medical Hypotheses - November 21, 2012 Category: Biomedical Science Authors: Michael B. Altman, Michael J. Flynn, Robert M. Nishikawa, Indrin J. Chetty, Kenneth N. Barton, Benjamin Movsas, Jae Ho Kim, Stephen L. Brown Tags: Articles Source Type: research

Multiphysics model of a rat ventricular myocyte: A voltage-clamp study
Conclusions: Extensive testing of the composite model elucidates the importance of various direct and indirect modulatory influences on cellular twitch response with wide agreement with measured data on all accounts. Thus, the model provides mechanistic insights into whole-cell responses to a wide variety of testing approaches used in studies of cardiac myofilament contractility that have appeared in the literature over the past several decades.
Source: Theoretical Biology and Medical Modelling - November 21, 2012 Category: Biomedical Science Authors: Abhilash KrishnaMiguel ValderrabanoPhilip PaladeJohn Clark Source Type: research

CO2 or bicarbonate for algal lipid production
Source: Biotechnology and Bioengineering - November 21, 2012 Category: Biomedical Science Tags: Spotlight Source Type: research

All cells are created equal but some are more equal than others
Source: Biotechnology and Bioengineering - November 21, 2012 Category: Biomedical Science Tags: Spotlight Source Type: research

Two‐step procedure for hyper‐production of lipids in fast growing microalgae
Source: Biotechnology and Bioengineering - November 21, 2012 Category: Biomedical Science Tags: Spotlight Source Type: research

Tracking cellulase behaviors
Source: Biotechnology and Bioengineering - November 21, 2012 Category: Biomedical Science Tags: Spotlight Source Type: research

Biotechnology and Bioengineering: Volume 110, Number 1, January 2013
Source: Biotechnology and Bioengineering - November 21, 2012 Category: Biomedical Science Tags: Contents Source Type: research

Fiber alignment directs cell motility over chemotactic gradients
Abstract The ability of tissue engineered scaffolds to direct cell behavior is paramount for scaffold design. Cell migration can be directed by various methods including chemical, adhesive, mechanical, and topographical cues. Electrospinning has emerged as a popular method to control topography and create fibrous scaffolds similar to that found in extracellular matrix. One major hurdle is limited cell infiltration and several studies have explored methods to alter electrospun materials to increase scaffold porosity; however, uniform cell distributions within scaffolds is still limited. Towards this, we investigated the mot...
Source: Biotechnology and Bioengineering - November 21, 2012 Category: Biomedical Science Authors: Harini G. Sundararaghavan, Randi L. Saunders, Daniel A. Hammer, Jason A. Burdick Tags: Communication to the Editor Source Type: research

Improved production of 3‐hydroxypropionadehyde by complex formation with bisulfite during biotransformation of glycerol
Abstract 3‐Hydroxypropionaldehyde (3HPA) is an important specialty chemical which can be produced from glycerol using resting cells of Lactobacillus reuteri. This biocatalytic route, however, suffers from substrate‐ and product‐mediated loss of enzyme activity within 2 h of biotransformation. In order to overcome the inhibitory effects of 3HPA, complex formation with sodium bisulfite was investigated, optimized and applied for in situ capture of the aldehyde during biotransformation of glycerol in a fed‐batch process. As a result, the activity of the cells was maintained for at least 18 h. The 3HPA produced per gra...
Source: Biotechnology and Bioengineering - November 21, 2012 Category: Biomedical Science Authors: Roya R. R. Sardari, Tarek Dishisha, Sang‐Hyun Pyo, Rajni Hatti‐Kaul Tags: Communication to the Editor Source Type: research

Biocatalytic reduction of short‐chain carboxylic acids into their corresponding alcohols with syngas fermentation
Abstract Short‐chain carboxylic acids generated by various mixed‐ or pure‐culture fermentation processes have been considered valuable precursors for production of bioalcohols. While conversion of carboxylic acids into alcohols is routinely performed with catalytic hydrogenation or with strong chemical reducing agents, here, a biological conversion route was explored. The potential of carboxydotrophic bacteria, such as Clostridium ljungdahlii and Clostridium ragsdalei, as biocatalysts for conversion of short‐chain carboxylic acids into alcohols, using syngas as a source of electrons and energy is demonstrated. Acet...
Source: Biotechnology and Bioengineering - November 21, 2012 Category: Biomedical Science Authors: Jose M. Perez, Hanno Richter, Sarah E. Loftus, Largus T. Angenent Tags: Article Source Type: research

Cellular Trafficking of Cell Stress Proteins in Health and Disease
series:Heat Shock ProteinsSince the beginning of the 21st Century there has been a rapid increase in our understanding of the cellular trafficking mechanisms of molecular chaperones in eukaryotes and in prokaryotes. In the former, molecular chaperone trafficking can occur between the various cellular compartments, with concomitant movement of other proteins. Such events can also result in the release of molecular ...
Source: Springer Biomedical Sciences titles - November 20, 2012 Category: Biomedical Science Tags: Human Physiology Source Type: news

Proceedings of the National Academy of Sciences USA 109: E3268-3277 (11-20-12)
Proceedings of the National Academy of Sciences USA 109: E3268-3277 Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies Hugo Mouquet, Louise Scharf, Zelda Euler, Yan Liu, Caroline Eden, Johannes F. Scheid, Ariel Halper-Stromberg, Priyanthi N. P. Gnanapragasam, Daniel I. … More »
Source: The Rockefeller University Newswire - November 20, 2012 Category: Biomedical Science Authors: pubaff Tags: Research Update Source Type: news

Proceedings of the National Academy of Sciences USA 109: 19274-19279 (11-20-12)
Proceedings of the National Academy of Sciences USA 109: 19274-19279 Functional and structural analysis of the human SLO3 pH- and voltage-gated K+ channel Manuel D. Leonetti, Peng Yuan, Yichun Hsiung and Roderick MacKinnon
Source: The Rockefeller University Newswire - November 20, 2012 Category: Biomedical Science Authors: pubaff Tags: Research Update Source Type: news

Endocannabinoid signalling is required for estrogen-dependent modulation of inhibitory transmission.
PMID: 23151780 [PubMed - in process]
Source: Journal of Biosciences - November 20, 2012 Category: Biomedical Science Authors: Tremere LA, Pinaud R Tags: J Biosci Source Type: research

Etroplus suratensis (Bloch), the State Fish of Kerala.
PMID: 23151781 [PubMed - in process]
Source: Journal of Biosciences - November 20, 2012 Category: Biomedical Science Authors: Padmakumar KG, Bindu L, Manu PS Tags: J Biosci Source Type: research

The Sad paradox: Mutations with dominant and recessive phenotypes.
PMID: 23151782 [PubMed - in process]
Source: Journal of Biosciences - November 20, 2012 Category: Biomedical Science Authors: Kasbekar DP Tags: J Biosci Source Type: research

Early modern natural history: Contributions from the Americas and India.
PMID: 23151783 [PubMed - in process]
Source: Journal of Biosciences - November 20, 2012 Category: Biomedical Science Authors: Kochhar R Tags: J Biosci Source Type: research

What history tells us XXIX. Transfers from plant biology: From cross protection to RNA interference and DNA vaccination.
PMID: 23151784 [PubMed - in process]
Source: Journal of Biosciences - November 20, 2012 Category: Biomedical Science Authors: Morange M Tags: J Biosci Source Type: research

Crowding, molecular volume and plasticity: An assessment involving crystallography, NMR and simulations.
Crowding, molecular volume and plasticity: An assessment involving crystallography, NMR and simulations. J Biosci. 2012 Dec;37(6):953-63 Authors: Selvaraj M, Ahmad R, Varshney U, Vijayan M Abstract The discrepancy between the X-ray and NMR structures of Mycobacterium tuberculosis peptidyl-tRNA hydrolase in relation to the functionally important plasticity of the molecule led to molecular dynamics simulations. The X-ray and the NMR studies along with the simulations indicated an inverse correlation between crowding and molecular volume. A detailed comparison of proteins for which X-ray and the NMR structures...
Source: Journal of Biosciences - November 20, 2012 Category: Biomedical Science Authors: Selvaraj M, Ahmad R, Varshney U, Vijayan M Tags: J Biosci Source Type: research

Efficient multi-site-directed mutagenesis directly from genomic template.
Abstract In this article, the traditional multi-site-directed mutagenesis method based on overlap extension PCR was improved specifically for complicated templates, such as genomic sequence or complementary DNA. This method was effectively applied for multi-site-directed mutagenesis directly from mouse genomic DNA, as well as for combination, deletion or insertion of DNA fragments. PMID: 23151786 [PubMed - in process]
Source: Journal of Biosciences - November 20, 2012 Category: Biomedical Science Authors: Luo F, Du X, Weng T, Wen X, Huang J, Chen L Tags: J Biosci Source Type: research