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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 9.

Recent bioanalytical methods for quantification of third-generation cephalosporins using HPLC and LC-MS(/MS) and their applications in pharmacokinetic studies.
Abstract Third-generation cephalosporins are semi-synthetic antibiotics with enhanced activity against Gram-negative organisms. The cephalosporins in biological samples are mostly determined using high-performance liquid chromatography (HPLC) and HPLC-mass spectrometry (LC-MS) or tandem mass spectrometry (LC-MS/MS). In recent years, numerous bioanalytical methods have been developed to improve the sensitivity and specificity of cephalosporin quantification using the powerful LC-MS/MS systems that are common in research laboratories. This review article presents recently developed bioanalytical methods by HPLC or LC...
Source: Biomedical Chromatography : BMC - October 8, 2014 Category: Biomedical Science Authors: Jin HE, Jin SE, Maeng HJ Tags: Biomed Chromatogr Source Type: research

Development and validation of a rapid HPLC method for quantitation of SP-141, a novel pyrido[b]indole anticancer agent, and an initial pharmacokinetic study in mice.
Abstract There is an increasing interest in targeting the MDM2 oncogene for cancer therapy. SP-141, a novel designed small molecule MDM2 inhibitor, exerts excellent in vitro and in vivo anticancer activity. To facilitate the preclinical development of this candidate anticancer agent, we have developed an HPLC method for the quantitative analysis of SP-141. The method was validated to be precise, accurate, and specific, with a linear range of 16.2-32,400 ng/mL in plasma, 16.2-6480 ng/mL in homogenates of brain, heart, liver, kidneys, lungs, muscle and tumor, and 32.4-6480 ng/mL in spleen homogenates. The lower...
Source: Biomedical Chromatography : BMC - October 8, 2014 Category: Biomedical Science Authors: Nag S, Qin JJ, Voruganti S, Wang MH, Sharma H, Patil S, Buolamwini JK, Wang W, Zhang R Tags: Biomed Chromatogr Source Type: research

Comparison of a carbohydrate-free diet vs. fasting on plasma glucose, insulin and glucagon in type 2 diabetes
Hyperglycemia improves when patients with type 2 diabetes are placed on a weight-loss diet. Improvement typically occurs soon after diet implementation. This rapid response could result from low fuel supply (calories), lower carbohydrate content of the weight-loss diet, and/or weight loss per se. To differentiate these effects, glucose, insulin, C-peptide and glucagon were determined during the last 24h of a 3-day period without food (severe calorie restriction) and a calorie-sufficient, carbohydrate-free diet. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - October 8, 2014 Category: Biomedical Science Authors: Frank Q. Nuttall, Rami M. Almokayyad, Mary C. Gannon Source Type: research

Leptin and Adiponectin During the First Week After Kidney Transplantation: Biomarkers of Graft Dysfunction?
Context and ObjectiveBased on evidence that leptin and adiponectin are removed from circulation primarily by the kidney, we designed a study to examine the longitudinal changes of these adipokines during the first week after kidney transplantation (KTx) and to test the hypothesis that higher levels of leptin and/or adiponectin could be early biomarkers of delayed graft function (DGF=dialysis requirement during the first post-transplant week) and acute rejection.Study DesignRepeated-measures prospective study (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - October 8, 2014 Category: Biomedical Science Authors: Isabel Fonseca, José Carlos Oliveira, Josefina Santos, Jorge Malheiro, La Salete Martins, Manuela Almeida, Leonídio Dias, Sofia Pedroso, Luísa Lobato, António Castro Henriques, Denisa Mendonça Source Type: research

Obesity and asthma: beyond T2 inflammation
Obesity is a major risk factor for asthma. Likewise, obesity is known to increase disease severity in asthmatic subjects and also to impair the efficacy of first-line treatment medications for asthma, worsening asthma control in obese patients. This concept is in agreement with the current understanding that some asthma phenotypes are not accompanied by detectable inflammation, and may not be ameliorated by classical anti-inflammatory therapy. There are growing evidences suggesting that the obesity-related asthma phenotype does not necessarily involve the classical TH2-dependent inflammatory process. (Source: Metabolism - ...
Source: Metabolism - Clinical and Experimental - October 8, 2014 Category: Biomedical Science Authors: Luiz O.S. Leiria, Milton A. Martins, Mário J.A. Saad Source Type: research

Serum total bilirubin and long-term outcome in patients undergoing percutaneous coronary intervention.
CONCLUSIONS: High STB concentration is associated with lower MACE in patients with ACS after PCI. PMID: 25282141 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - October 7, 2014 Category: Biomedical Science Authors: Zhang XJ, Sun TW, Kan QC, Yao HM, Wan YD, Yao R, Guan FX, Guo CQ, Zhang SG, Sun WJ, Wang LX Tags: Clin Invest Med Source Type: research

Adropin: a new marker for predicting late saphenous vein graft disease after coronary artery bypass grafting.
CONCLUSIONS: Adropin levels are lower in patients with late saphenous vein graft occlusion and these reduced adropin levels, together with other factors, may lead to saphenous vein graft occlusion. Larger and prospective studies are needed to determine if adropin plays a role in the pathogenesis of SVGD. PMID: 25282140 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - October 7, 2014 Category: Biomedical Science Authors: Demircelik B, Cakmak M, Nazli Y, Gurel OM, Akkaya N, Cetin M, Cetin Z, Selcoki Y, Kurtul A, Eryonucu B Tags: Clin Invest Med Source Type: research

Characterization of the withdrawal phase in a swine controlled intestinal donation after circulatory death model.
CONCLUSION: A new swine CDCD model, simulating three stages of "withdrawal of ventilation, systemic anticoagulation and determination of death", which closely mimics the human DCD scenario and can thus be used in studies related to organ transplantation, was successfully established. PMID: 25282139 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - October 7, 2014 Category: Biomedical Science Authors: Guo M, Li L, Lu C Tags: Clin Invest Med Source Type: research

Evaluation of E-cadherin, β-catenin and vimentin protein expression using quantitative immunohistochemistry in nasopharyngeal carcinoma patients.
CONCLUSION: In this cohort of NPC patients, higher levels of E-cadherin and higher levels of vimentin were associated with worse outcomes. Further work is needed to understand the role of these epithelial mesenchymal transition proteins in NPC. PMID: 25282138 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - October 7, 2014 Category: Biomedical Science Authors: Hao D, Phan T, Jagdis A, Siever JE, Klimowicz AC, Laskin JJ, Thomson TA, Rose MS, Petrillo SK, Magliocco AM, Lau HY Tags: Clin Invest Med Source Type: research

'INSPIRED' COPD Outreach ProgramTM: Doing the Right Things Right.
'INSPIRED' COPD Outreach Program<sup>TM</sup>: Doing the Right Things Right. Clin Invest Med. 2014;37(5):E311 Authors: Rocker GM, Verma JY Abstract The well-documented gaps between needed and provided care for patients and families living with chronic obstructive pulmonary disease (COPD) mandate changes to clinical practice. The multifaceted evidence-based INSPIRED COPD Outreach ProgramTM was first implemented in Halifax, Nova Scotia, Canada in 2010 (INSPIRED = Implementing a Novel and Supportive Program of Individualized care for patients and families living with REspiratory Disease) and u...
Source: Clinical and Investigative Medicine - October 7, 2014 Category: Biomedical Science Authors: Rocker GM, Verma JY Tags: Clin Invest Med Source Type: research

Proceedings from the 5th annual university of calgary leaders in medicine research symposium.
Abstract On November 8, 2013, the Leaders in Medicine (LIM) program hosted the 5th Annual Research Symposium. Dr. Jerrold Ellner, Chief of the Infectious Diseases section at Boston Medical Centre and Professor of Medicine at Boston University School of Medicine, was the keynote speaker and presented his lecture entitled "Tuberculosis - Past, Present and Future". The LIM symposium gives a forum for LIM as well as non-LIM medical students to present their research work as either an oral or poster presentation. There were a total of 53 abstracts presented and five oral presentations. The symposium was attended by over...
Source: Clinical and Investigative Medicine - October 7, 2014 Category: Biomedical Science Authors: Thornton CS, Keough MB, Roberts JI, Yipp B, Hollenberg M, Bau JT, Peplowski MA, Beck PL Tags: Clin Invest Med Source Type: research

A Prescription that Addresses the Decline of Basic Science Education in Medical School.
Abstract Over 30 years ago a cry rang out through the proverbial halls of academia; "The clinician scientist is an endangered species." These prophetic words have been reverberated in the ears of every specialty and every general medical organization in deafening tones. Why is the role of the clinician scientist or clinician investigator so important that this phrase has been repeated subsequently in medical and educational journals? Simply put, the clinician scientist bridges the ravine between the ever-growing mountain of scientific knowledge and the demanding patient centered clinical care. Here, we describe the...
Source: Clinical and Investigative Medicine - October 7, 2014 Category: Biomedical Science Authors: Miller D, Thornton CS, Keough MB, Roberts JI, Yipp B, Hollenberg M, Bau JT, Peplowski MA, Beck PL Tags: Clin Invest Med Source Type: research

Challenges Facing Physician Scientist Trainees: a Survey of Trainees in Canada's Largest Undergraduate and Postgraduate Programs in a Single Centre.
CONCLUSION: These findings indicate that while trainees at different stages consistently express career motivation, they identified concerns that are program- and training stage-specific. These concerns mirror those highlighted in the medical education literature regarding threats to the physician scientist career path. Understanding these different and changing perspectives and exploring those differences could form an important basis for trainee program improvements both nationally and internationally. PMID: 25282134 [PubMed - in process] (Source: Clinical and Investigative Medicine)
Source: Clinical and Investigative Medicine - October 7, 2014 Category: Biomedical Science Authors: Ballios BG, Rosenblum ND Tags: Clin Invest Med Source Type: research

Executive Director's Statement on the Occasion of the International Day of Older Persons - 01 October 2014
On this 24th International Day of Older Persons, UNFPA, the United Nations Population Fund, joins the worldwide celebration of longevity and acknowledges the contributions that older persons make to their families, communities and societies. We celebrate the fact that more people are living longer and healthier lives. This is due to improvements in nutrition, sanitation, medical science, health care, education and economic well-being. (Source: UNFPA News)
Source: UNFPA News - October 7, 2014 Category: Global & Universal Source Type: news

Rockefeller neurobiology lab is awarded first-round BRAIN initiative grant
Researchers are developing a technology to remotely turn neurons and other cells on or off. The bright spots represent cells undergoing a change that would enable neurons to fire on command. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - October 7, 2014 Category: Biomedical Science Authors: pubaff Tags: Awards and Honors BRAIN Initiative neuroscience radiogenetics Sarah Stanley Source Type: news

Executive Director's Statement on the Occasion of the International Day of Older Persons - 01 October 2014
On this 24th International Day of Older Persons, UNFPA, the United Nations Population Fund, joins the worldwide celebration of longevity and acknowledges the contributions that older persons make to their families, communities and societies. We celebrate the fact that more people are living longer and healthier lives. This is due to improvements in nutrition, sanitation, medical science, health care, education and economic well-being. (Source: UNFPA News)
Source: UNFPA News - October 7, 2014 Category: Global & Universal Source Type: news

The implantation of cervical neoplasia at postpartum episiotomy scar: the clinical evidence
Conclusion Clinicians should be aware about the importance of carefully examining not only the cervix at the time of labor, but also the episiotomy scar in women following a pregnancy complicated by cervical cancer. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - October 7, 2014 Category: Journals (General) Source Type: research

Pharmacoeconomic study of chronic constipation in a secondary care centre
Conclusion This study validated the findings of the NICE costing template and suggests that the use of prucalopride for the treatment of chronic constipation in women refractory to laxatives has the potential to reduce secondary care resource use and hence led to cost savings. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - October 7, 2014 Category: Journals (General) Source Type: research

Inter-relationships between proprotein convertase subtilisin/kexin type 9, apolipoprotein C-III and plasma apolipoprotein B-48 transport in obese subjects: a stable isotope study in the postprandial state
Postprandial lipaemia, due to elevated plasma apolipoprotein (apo) B-48 concentrations, contributes to increased cardiovascular risk in obesity. Proprotein convertase subtilisin/kexin type 9 (PCSK9) and apoC-III may play a role in regulating apoB-48 metabolism. We investigated the associations between plasma PCSK9 and apoC-III concentrations and the kinetics of apoB-48 in obese subjects.Seventeen obese subjects were given an oral fat load. ApoB-48 tracer/tracee ratios were measured after intravenous d3-leucine administration using gas chromatography-mass spectrometry. Kinetic parameters, including secretion and fractional ...
Source: Clinical Science - October 7, 2014 Category: Biomedical Science Authors: D C Chan, A Y Wong, J Pang, P R Barrett, G F Watts Source Type: research

A hybrid approach to the computational aeroacoustics of human voice production.
Abstract The aeroacoustic mechanisms in human voice production are complex coupled processes that are still not fully understood. In this article, a hybrid numerical approach to analyzing sound generation in human voice production is presented. First, the fluid flow problem is solved using a parallel finite-volume computational fluid dynamics (CFD) solver on a fine computational mesh covering the larynx. The CFD simulations are run for four geometrical configurations: both with and without false vocal folds, and with fixed convergent or convergent-divergent motion of the medial vocal fold surface. Then the aeroacou...
Source: Biomechanics and Modeling in Mechanobiology - October 7, 2014 Category: Biomedical Science Authors: Sidlof P, Zörner S, Hüppe A Tags: Biomech Model Mechanobiol Source Type: research

Regional Heritability Mapping to identify loci underlying genetic variation of complex traits
Conclusions RHM identified the largest QTL among the simulated ones, with some signals for the ones with small effect. Moreover, RHM performed better than association and linkage analysis, in terms of both power and resolution. (Source: BMC Proceedings)
Source: BMC Proceedings - October 7, 2014 Category: Biomedical Science Source Type: research

A selective genotyping approach identifies QTL in a simulated population
Conclusions In this study we proposed a simple method to identify genomic regions associated to the phenotype under study. The identification of the DNA region is the first step to search for the mutation which is really responsible for the trait variability, through the direct sequencing of the genome regions that encode the QTL. (Source: BMC Proceedings)
Source: BMC Proceedings - October 7, 2014 Category: Biomedical Science Source Type: research

Genome wide association analysis of the QTL MAS 2012 data investigating pleiotropy
Conclusions Principal component and multivariate analyses seem to be promising in order to characterize the genetic basis of trait relationships. (Source: BMC Proceedings)
Source: BMC Proceedings - October 7, 2014 Category: Biomedical Science Source Type: research

Genome wide association analysis of the 16th QTL- MAS Workshop dataset using the Random Forest machine learning approach
Conclusions The results of the RF approach were confirmed by the GRAMMAR-CG method and validated by the effective QTL position, even if their approach to unravel cryptic genetic structure is different. Furthermore, both methods showed complementary findings. However, when the variance explained by the QTL is low, they both failed to detect significant associations. (Source: BMC Proceedings)
Source: BMC Proceedings - October 7, 2014 Category: Biomedical Science Source Type: research

Estimation of genomic breeding values using the Horseshoe prior
Conclusions The Horseshoe prior showed a different shrinkage pattern than the other methods. While for this specific dataset, this has little impact on the accuracy of the GEBV, it may prove a good property to discriminate true effect from noise, and thereby, improve overall prediction under different scenarios. (Source: BMC Proceedings)
Source: BMC Proceedings - October 7, 2014 Category: Biomedical Science Source Type: research

XVI th QTLMAS: simulated dataset and comparative analysis of submitted results for QTL mapping and genomic evaluation
Conclusions The best results in terms of detection power were obtained by ridge regression that, however, led to a large number of false positives. Good results both in terms of true detections and false positives were obtained by the approaches that fit polygenic effects in the model. The investigation of the pleiotropic nature of the QTL permitted the identification of few additional markers compared to the single-trait analyses. Bayesian and grouped regularized regression methods performed similarly for genomic prediction while GBLUP produced the poorest results. (Source: BMC Proceedings)
Source: BMC Proceedings - October 7, 2014 Category: Biomedical Science Source Type: research

Regularized group regression methods for genomic prediction: Bridge, MCP, SCAD, group bridge, group lasso, sparse group lasso, group MCP and group SCAD
Conclusions All the regularization methods considered produced satisfactory predictive accuracies for most practical purposes and thus deserve serious consideration in genomic prediction research and practice. Grouping markers did not enhance predictive accuracy for the synthetic data set considered. But other more sophisticated grouping schemes could potentially enhance accuracy. Using cross validation to select the penalty parameters for the methods often yielded more accurate estimates of predictive accuracy than using information theoretic criteria. (Source: BMC Proceedings)
Source: BMC Proceedings - October 7, 2014 Category: Biomedical Science Source Type: research

Association between methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C polymorphisms and essential hypertension: A systematic review and meta-analysis
Many studies have investigated the role of 5,10-methylenetetrahydrofolate reductase gene (MTHFR) C677T/A1298C polymorphisms in essential hypertension (EH), but results are inconclusive. The purpose of this meta-analysis was to clarify the effects of MTHFR C677T/A1298C polymorphisms on the risk of EH. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - October 7, 2014 Category: Biomedical Science Authors: Yi-Le Wu, Cai-Yun Hu, Shan-Shan Lu, Feng-Feng Gong, Fang Feng, Zhen-Zhong Qian, Xiu-Xiu Ding, Hui-Yun Yang, Ye-Huan Sun Source Type: research

Impact of oxidative stress on cellular biomechanics and rho signaling in C2C12 myoblasts
In this study, we used C2C12 myoblasts to investigate the effect of oxidative stress, mimicked by hydrogen peroxide (H2O2), on the cell elasticity (i.e., Young׳s modulus), viability, and production of intracellular reactive oxygen species (ROS). (Source: Journal of Biomechanics)
Source: Journal of Biomechanics - October 7, 2014 Category: Biomedical Science Authors: Shan Sun, Singwan Wong, Arthur Mak, Michael Cho Source Type: research

Fitted hyperelastic parameters for Human brain tissue from reported tension, compression, and shear tests
The mechanical properties of human brain tissue are the subject of interest because of their use in understanding brain trauma and in developing therapeutic treatments and procedures. To represent the behavior of the tissue, we have developed hyperelastic mechanical models whose parameters are fitted in accordance with experimental test results. However, most studies available in the literature have fitted parameters with data of a single type of loading, such as tension, compression, or shear. Recently, Jin et al. (Source: Journal of Biomechanics)
Source: Journal of Biomechanics - October 7, 2014 Category: Biomedical Science Authors: Richard Moran, Joshua H. Smith, José J. García Tags: Short communication Source Type: research

Temperature as a predictive tool for plantar triaxial loading
Diabetic foot ulcers are caused by moderate repetitive plantar stresses in the presence of peripheral neuropathy. In severe cases, the development of these foot ulcers can lead to lower extremity amputations. Plantar pressure measurements have been considered a capable predictor of ulceration sites in the past, but some investigations have pointed out inconsistencies when solely relying on this method. The other component of ground reaction forces/stresses, shear, has been understudied due to a lack of adequate equipment. (Source: Journal of Biomechanics)
Source: Journal of Biomechanics - October 7, 2014 Category: Biomedical Science Authors: Metin Yavuz, Ryan W. Brem, Brian L. Davis, Jalpa Patel, Abe Osbourne, Megan R. Matassini, David A. Wood, Irene O. Nwokolo Tags: Short communication Source Type: research

Quantitative analysis of brain microstructure following mild blunt and blast trauma
We induced mild blunt and blast injuries in rats using a custom-built device and utilized in-house diffusion tensor imaging (DTI) software to reconstruct 3-D fiber tracts in brains before and after injury (1, 4, and 7 days). DTI measures such as fiber count, fiber length, and fractional anisotropy (FA) were selected to characterize axonal integrity. In-house image analysis software also showed changes in parameters including the area fraction (AF) and nearest neighbor distance (NND), which corresponded to variations in the microstructure of Hematoxylin and Eosin (H&E) brain sections. (Source: Journal of Biomechanics)
Source: Journal of Biomechanics - October 7, 2014 Category: Biomedical Science Authors: M.T. Begonia, R. Prabhu, J. Liao, W.R. Whittington, A. Claude, B. Willeford, J. Wardlaw, R. Wu, S. Zhang, L.N. Williams Source Type: research

Corrigendum to “Effects of fluid structure interaction in a three dimensional model of the spinal subarachnoid space” [J. Biomech. 47 (11) (2014) 2826–2830]
The authors regret that there is an error in the published version of Fig. 4B. The deformations of the spinal cord shown in Fig. 4B were not at 40% and 90% of the cardiac cycle as specified. This is corrected in the revised figure, which now shows spinal cord deformations consistent with those in Fig. 4A. (Source: Journal of Biomechanics)
Source: Journal of Biomechanics - October 7, 2014 Category: Biomedical Science Authors: Shaokoon Cheng, David Fletcher, Sarah Hemley, Marcus Stoodley, Lynne Bilston Tags: Corrigendum Source Type: research

Safety and efficacy of 2,790-nm laser resurfacing for chest photoaging
The objective of this study was to assess the safety and efficacy of 2,790-nm chest resurfacing for photodamage. Twelve patients with Fitzpatrick skin types I–III were enrolled in this university IRB-approved study. Photo documentation was obtained at baseline and each visit. A test spot with the 2,790-nm resurfacing laser was performed on the chest. Patients who did not have adverse effects from the test spot went on to have a full chest resurfacing procedure. Patients were instructed on standardized aftercare, including sunscreen. A 5-point healing and photodamage improvement scale was used to rate improvement by both ...
Source: Lasers in Medical Science - October 6, 2014 Category: Laser Surgery Source Type: research

Efficacy of LED versus KTP laser activation of photodynamic bleaching of tetracycline-stained dentine
This study compared the relative efficacy of an array of visible green LED (535 nm ± 15 nm) with a KTP laser in photodynamic bleaching of tetracycline-stained dentine in human tooth roots. After establishing consistent staining in 96 roots using a validated method, the roots were sectioned into 2–3-mm thick horizontal slices that were treated with gels containing rhodamine B (Smartbleach® or Smartbleach® 3LT). Colour changes were tracked up to 1 month after treatment. While both systems were effective in bleaching the tetracycline-stained dentine, KTP laser activation gave greater bleaching efficacy than LED ac...
Source: Lasers in Medical Science - October 6, 2014 Category: Laser Surgery Source Type: research

Photodynamic effects of zinc phthalocyanines on intracellular amastigotes of Leishmania amazonensis and Leishmania braziliensis
This study investigated the photoactivity of four zinc phthalocyanines (PcZns) on a murine macrophage cell line infected with Leishmania amazonensis or Leishmania braziliensis. Infected and uninfected cells were incubated with PcZns at different concentrations (1–10 μM) for 3 h and then exposed to an LED device in continuous wave mode at 660 nm with a fluency of 50 J/cm2 (25 mV). Enzymatic activity was determined by MTT assay 24 h after light treatment. The results demonstrated that all PcZns exhibited high photoactivity, particularly when used at 10 μM. The photodynamic effects were different for uninfected cel...
Source: Lasers in Medical Science - October 6, 2014 Category: Laser Surgery Source Type: research

Executive Director's Statement on the Occasion of the International Day of Older Persons - 01 October 2014
On this 24th International Day of Older Persons, UNFPA, the United Nations Population Fund, joins the worldwide celebration of longevity and acknowledges the contributions that older persons make to their families, communities and societies. We celebrate the fact that more people are living longer and healthier lives. This is due to improvements in nutrition, sanitation, medical science, health care, education and economic well-being. (Source: UNFPA News)
Source: UNFPA News - October 6, 2014 Category: Global & Universal Source Type: news

"Modern Medical Science and the Divine Providence of God": Rethinking the Place of Religion in Postwar U.S. Medical History
Drawing on a large cache of letters to John and Frances Gunther after the death of their son as well as memoirs and fiction by bereaved parents, this essay challenges the assumptions of secularization that infuse histories of twentieth-century American medicine. Many parents who experienced the death of children during the postwar period relied heavily on religion to help make sense of the tragedies medicine could not prevent. Parental accounts included expression of belief in divine intervention and the power of prayer, gratitude for God's role in minimizing suffering, confidence in the existence of an afterlife, and acce...
Source: Journal of the History of Medicine and Allied Sciences - October 6, 2014 Category: History of Medicine Authors: Golden, J., Abel, E. K. Tags: Articles Source Type: research

NMR structure of the water soluble Aβ17-34 peptide.
In this study, we determine the nuclear magnetic resonance (NMR) structure of an Aβ17-34 peptide solubilized by the addition of two glutamic acids at each terminus. Our results indicate that the Aβ peptide adopts an α-helical structure for residues 19-26 and 28-33. The α-helical structure is broken around residues S26, N27, and K28, which form a kink in the helical conformation. This α-helix was not described earlier in an aqueous solution without organic solvents, and at physiological conditions (pH 7). These data are in agreement with Aβ adopting an α-helical conformation in the membrane before polymerizing into a...
Source: Bioscience Reports - October 6, 2014 Category: Biomedical Science Authors: Fonar G, Samson AO Tags: Biosci Rep Source Type: research

Integrating multi‐scale knowledge on cardiac development into a computational model of ventricular trabeculation
Insights into the mechanisms of development of the mammalian four‐chambered heart are based on biological observations at organ, tissue, cell, and molecular levels, but the full integration of these experimental data awaits a systems biology approach. Such an approach can be employed to formulate and test conceptual models in a computational simulation. To illustrate how this can be applied to heart development, we used the process of trabeculation, which is the formation of muscular strands during chamber development. We selected this process because it is localized, involves a restricted number of cell types, and a ran...
Source: Wiley Interdisciplinary Reviews: Systems Biology and Medicine - October 6, 2014 Category: Biomedical Science Authors: Bouke A. de Boer, Jean‐François Le Garrec, Vincent M. Christoffels, Sigolène M. Meilhac, Jan M. Ruijter Tags: Focus Article Source Type: research

antigen B: A Hydrophobic Ligand Binding Protein at the host–parasite interface
Lipids are mainly solubilized by various families of lipid binding proteins which participate in their transport between tissues as well as cell compartments. Among these families, Hydrophobic Ligand Binding Proteins (HLBPs) deserve special consideration since they comprise intracellular and extracellular members, are able to bind a variety of fatty acids, retinoids and some sterols, and are present exclusively in cestodes. Since these parasites have lost catabolic and biosynthetic pathways for fatty acids and cholesterol, HLBPs are likely relevant for lipid uptake and transportation between parasite and host cells. (Sourc...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - October 6, 2014 Category: Biomedical Science Authors: Valeria Silva-Álvarez, Ana Maite Folle, Ana Lía Ramos, Fernando Zamarreño, Marcelo D. Costabel, Eduardo García-Zepeda, Gustavo Salinas, Betina Córsico, Ana María Ferreira Source Type: research

Characterization and assessment of hyperelastic and elastic Properties of decellularized Human adipose tissues
Decellularized adipose tissue (DAT) has shown potential as a regenerative scaffold for plastic and reconstructive surgery to augment or replace damaged or missing adipose tissue (e.g. following lumpectomy or mastectomy). The mechanical properties of soft tissue substitutes are of paramount importance in restoring the natural shape and appearance of the affected tissues, and mechanical mismatching can lead to unpredictable scar tissue formation and poor implant integration. The goal of this work was to assess the linear elastic and hyperelastic properties of decellularized human adipose tissue and compare them to those of n...
Source: Journal of Biomechanics - October 6, 2014 Category: Biomedical Science Authors: Ehsan Omidi, Lydia Fuetterer, Seyed Reza Mousavi, Ryan C. Armstrong, Lauren E. Flynn, Abbas Samani Source Type: research

On the kinematics and efficiency of advective mixing during gastric digestion – A numerical analysis
The mixing performance of gastric contents during digestion is expected to have a major role on the rate and final bioavailability of nutrients within the body. The aim of this study was to characterize the ability of the human stomach to advect gastric contents with different rheological properties. The flow behavior of two Newtonian fluids (10−3Pas, 1Pas) and a pseudoplastic solution (K=0.223Pas0.59) during gastric digestion were numerically characterized within a simplified 3D model of the stomach geometry and motility during the process (ANSYS-FLUENT). (Source: Journal of Biomechanics)
Source: Journal of Biomechanics - October 6, 2014 Category: Biomedical Science Authors: Maria J. Ferrua, Zhengjun Xue, R. Paul Singh Source Type: research

Executive Director's Statement on the Occasion of the International Day of Older Persons - 01 October 2014
On this 24th International Day of Older Persons, UNFPA, the United Nations Population Fund, joins the worldwide celebration of longevity and acknowledges the contributions that older persons make to their families, communities and societies. We celebrate the fact that more people are living longer and healthier lives. This is due to improvements in nutrition, sanitation, medical science, health care, education and economic well-being. (Source: UNFPA News)
Source: UNFPA News - October 5, 2014 Category: Global & Universal Source Type: news

‘Programmable’ antibiotic harnesses an enzyme to attack drug-resistant microbes
By co-opting a system bacteria normally use to defend themselves, researchers targeted and killed off colonies of the antibiotic resistant Staph cells on mouse skin. The treatment left behind the drug-susceptible microbes. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - October 5, 2014 Category: Biomedical Science Authors: pubaff Tags: Science News antibiotic resistance Cas9 CRISPR David Bikard Luciano Marraffini Vincent Fischetti Source Type: news

Characteristics of New Hybrid Plasmonic Bragg Reflectors Based on Sinusoidal and Triangular Gratings
Abstract In this paper, new structures for hybrid plasmonic Bragg reflectors (HPBRs), based on sinusoidal and triangular gratings, are proposed. The proposed structures exhibit better characteristics compared to previously studied rectangular HPBRs. Among these two structures, the triangular HPBR exhibits a better performance in terms of passband ripples and bandwidth than that of the sinusoidal one. Therefore, the structure of a microcavity as a defect in the proposed triangular HPBR is studied and its Q factor is compared with other types of plasmonic microcavities. It is also demonstrated that an apodization te...
Source: Plasmonics - October 5, 2014 Category: Biomedical Science Source Type: research

Lapatinib Ameliorates Experimental Arthritis in Rats
In conclusion, EGFR may have prominent pathogenic role and lapatinib may be an effective therapeutic option for arthritis. (Source: Inflammation)
Source: Inflammation - October 5, 2014 Category: Biomedical Science Source Type: research

An Embedded Automaton to Monitor the Glycolysis Process in Pancreatic β-Cells.
In this study, the designed machine can be used to regulate the process of glycolysis through a group of regulatory glycolytic enzymes for the treatment of Diabetes mellitus at molecular level. PMID: 25284330 [PubMed - as supplied by publisher] (Source: Acta Biotheoretica)
Source: Acta Biotheoretica - October 5, 2014 Category: Biomedical Science Authors: Selvakumar R, Muhammad MR, Devi GP Tags: Acta Biotheor Source Type: research

NMR-based structural biology enhanced by dynamic nuclear polarization at high magnetic field.
Abstract Dynamic nuclear polarization (DNP) has become a powerful method to enhance spectroscopic sensitivity in the context of magnetic resonance imaging and nuclear magnetic resonance spectroscopy. We show that, compared to DNP at lower field (400 MHz/263 GHz), high field DNP (800 MHz/527 GHz) can significantly enhance spectral resolution and allows exploitation of the paramagnetic relaxation properties of DNP polarizing agents as direct structural probes under magic angle spinning conditions. Applied to a membrane-embedded K(+) channel, this approach allowed us to refine the membrane-embedded channel structu...
Source: Journal of Bimolecular NMR - October 5, 2014 Category: Biomedical Science Authors: Koers EJ, van der Cruijsen EA, Rosay M, Weingarth M, Prokofyev A, Sauvée C, Ouari O, van der Zwan J, Pongs O, Tordo P, Maas WE, Baldus M Tags: J Biomol NMR Source Type: research

The effect of Glutathione-S-transferases in the susceptibility to bladder cancer
Conclusion Polymorphisms of these genes have been assessed to evaluate the relative risk of various cancers. Our intention is to continue this study with larger series of bladder cancer patients in a group of Turkish population from Central Anatolia. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - October 4, 2014 Category: Journals (General) Source Type: research