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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 9.

Establishment of Multiple Locus Variable-number Tandem Repeat Analysis Assay for Genotyping of Borrelia burgdorferi sensu lato Detected in China
Conclusion The MLVA protocol esytablished in this study is easy and can show strains' phylogenetic relationships to distinguish the strains of Borrelia species. It is useful for further phylogenetic and epidemiological analyses of Borrelia strains. (Source: Biomedical and Environmental Sciences)
Source: Biomedical and Environmental Sciences - November 9, 2014 Category: Biomedical Science Source Type: research

Toxicity of Multi-Walled Carbon Nanotubes, Graphene Oxide, and Reduced Graphene Oxide to Zebrafish Embryos
Conclusion MWCNTs, GO, and RGO were all toxic to zebrafish embryos to influence embryos hatching and larvae length. Although no obvious morphological malformation and mortality were observed in exposed zebrafish embryos, further studies on the toxicity of the three nanomaterials are still needed. (Source: Biomedical and Environmental Sciences)
Source: Biomedical and Environmental Sciences - November 9, 2014 Category: Biomedical Science Source Type: research

Pulmonary Immune Responses to Aspergillus Fumigatus in Rats
Conclusion Genetically-based differences in the pattern of antifungal lung leukocyte activities and cytokine milieu, associated with differential efficiency of fungal elimination might be useful in the future use of rat models in studies of pulmonary aspergillosis. (Source: Biomedical and Environmental Sciences)
Source: Biomedical and Environmental Sciences - November 9, 2014 Category: Biomedical Science Source Type: research

Nitrate-induced Biochemical and Histopathological Changes in the Liver of Rats: Ameliorative Effect of Hyparrhenia hirta
Conclusion The results concluded that the treatment with H. hirta had a significant role in protecting the animals from nitrate-induced liver dysfunction. (Source: Biomedical and Environmental Sciences)
Source: Biomedical and Environmental Sciences - November 9, 2014 Category: Biomedical Science Source Type: research

Environmental and Psycho-social Factors Related to Prostate Cancer Risk in the Chinese Population: a Case-control Study
Conclusion Regular consumption of green vegetables and green tea may suggest protective effects on PCa. Alcohol consumption, red meat consumption and barbecued or fried foods were associated with PCa. Negative psycho-social factors may also play a role in the incidence of PCa in Chinese population. (Source: Biomedical and Environmental Sciences)
Source: Biomedical and Environmental Sciences - November 9, 2014 Category: Biomedical Science Source Type: research

Medical Radiation Exposure and Human Carcinogenesis-Genetic and Epigenetic Mechanisms
Publication date: September 2014 Source:Biomedical and Environmental Sciences, Volume 27, Issue 9 Author(s): Yildiz Dincer , Zeynep Sezgin (Source: Biomedical and Environmental Sciences)
Source: Biomedical and Environmental Sciences - November 9, 2014 Category: Biomedical Science Source Type: research

X-ray-induced Expression Changes of TNFSF4 Gene in Human Peripheral Blood
Publication date: September 2014 Source:Biomedical and Environmental Sciences, Volume 27, Issue 9 Author(s): Shi En LI , Fei GUO , Ping WANG , Lin HAN , Yan GUO , Xi Ai WANG , Jie LI , Yu Min LYU (Source: Biomedical and Environmental Sciences)
Source: Biomedical and Environmental Sciences - November 9, 2014 Category: Biomedical Science Source Type: research

Development of A Reference Dose for BDE-47, 99, and 209 Using Benchmark Dose Methods
Publication date: September 2014 Source:Biomedical and Environmental Sciences, Volume 27, Issue 9 Author(s): Lu Xi LI , Li CHEN , Dan CAO , Bing Heng CHEN , Yan ZHAO , Xiang Zhou MENG , Chang Ming XIE , Yun Hui ZHANG (Source: Biomedical and Environmental Sciences)
Source: Biomedical and Environmental Sciences - November 9, 2014 Category: Biomedical Science Source Type: research

Enumeration, Genetic Characterization and Antimicrobial Susceptibility of Lactobacillus and Streptococcus Isolates from Retail Yoghurt in Beijing, China
Publication date: September 2014 Source:Biomedical and Environmental Sciences, Volume 27, Issue 9 Author(s): Yin Ping DONG , Qian CHEN , Sheng Hui CUI , Feng Qin LI (Source: Biomedical and Environmental Sciences)
Source: Biomedical and Environmental Sciences - November 9, 2014 Category: Biomedical Science Source Type: research

Endothelin XIII
Publication date: Available online 28 September 2014 Source:Life Sciences Author(s): Noriaki Emoto , Tomoh Masaki , Katsutoshi Goto , Paul M. Vanhoutte , Masashi Yanagisawa Twenty-five years ago, a groundbreaking paper from Tsukuba University in Japan was published, identifying the sequence of the endothelin gene and peptide (Nature 332, 411–415, 1988). This work opened the way for the discovery of the endothelin receptors and the development of orally active endothelin receptor antagonists (ERAs). Today, ERAs are part of medical therapy of patients around the world for the treatment of pulmonary arterial hypertension....
Source: Life Sciences - November 9, 2014 Category: Biology Source Type: research

Methods of biological fluids sample preparation - biogenic amines, methylxanthines, water-soluble vitamins.
Abstract In recent years demands on the amount of information that can be obtained from the analysis of a single sample have increased. For time and economic reasons it is necessary to examine at the same time larger number of compounds, and compounds from different groups. This can best be seen in such areas as clinical analysis. In many diseases, the best results for patients are obtained when treatment fits the individual characteristics of the patient. Dosage monitoring is important at the beginning of therapy and in the full process of treatment. In the treatment of many diseases biogenic amines (dopamine, ser...
Source: Biomedical Chromatography : BMC - November 9, 2014 Category: Biomedical Science Authors: Płonka J Tags: Biomed Chromatogr Source Type: research

A 3D time-shared NOESY experiment designed to provide optimal resolution for accurate assignment of NMR distance restraints in large proteins.
Abstract Structure determination of proteins by solution NMR has become an established method, but challenges increase steeply with the size of proteins. Notably, spectral crowding and signal overlap impair the analysis of cross-peaks in NOESY spectra that provide distance restraints for structural models. An optimal spectral resolution can alleviate overlap but requires prohibitively long experimental time with existing methods. Here we present a time-shared 3D experiment optimized for large proteins that provides (15)N and (13)C dispersed NOESY spectra in a single measurement. NOESY correlations appear in the det...
Source: Journal of Bimolecular NMR - November 9, 2014 Category: Biomedical Science Authors: Mishra SH, Harden BJ, Frueh DP Tags: J Biomol NMR Source Type: research

Fast magic angle spinning NMR with heteronucleus detection for resonance assignments and structural characterization of fully protonated proteins.
Abstract Heteronucleus-detected dipolar based correlation spectroscopy is established for assignments of (1)H, (13)C, and (15)N resonances and structural analysis in fully protonated proteins. We demonstrate that (13)C detected 3D experiments are highly efficient and permit assignments of the majority of backbone resonances, as shown in an 89-residue dynein light chain 8, LC8 protein. With these experiments, we have resolved many ambiguities that were persistent in our previous studies using moderate MAS frequencies and lacking the (1)H dimension. The availability of (1)H isotropic chemical shifts measured with the...
Source: Journal of Bimolecular NMR - November 9, 2014 Category: Biomedical Science Authors: Guo C, Hou G, Lu X, O'Hare B, Struppe J, Polenova T Tags: J Biomol NMR Source Type: research

MicroRNAs meet calcium: Joint venture in ER proteostasis.
Abstract The endoplasmic reticulum (ER) is a cellular compartment that has a key function in protein translation and folding. Maintaining its integrity is of fundamental importance for organism's physiology and viability. The dynamic regulation of intraluminal ER Ca(2+) concentration directly influences the activity of ER-resident chaperones and stress response pathways that balance protein load and folding capacity. We review the emerging evidence that microRNAs play important roles in adjusting these processes to frequently changing intracellular and environmental conditions to modify ER Ca(2+) handling and stora...
Source: Science Signaling - November 8, 2014 Category: Biomedical Science Authors: Finger F, Hoppe T Tags: Sci Signal Source Type: research

Protein folding creates structure-based, noncontiguous consensus phosphorylation motifs recognized by kinases.
We report the identification of Thr(253) in α-tubulin as a site that is phosphorylated by protein kinase C βI (PKCβI). Thr(253) is not part of a linear PKC consensus motif. Instead, Thr(253) occurs within a region on the surface of α-tubulin that resembles a PKC phosphorylation site consensus motif formed by basic residues in different parts of the protein, which come together in the folded protein to form the recognition motif for PKCβI. Mutations of these basic residues decreased substrate phosphorylation, confirming the presence of this "structurally formed" consensus motif and its importance for the protein kinase...
Source: Science Signaling - November 8, 2014 Category: Biomedical Science Authors: Duarte ML, Pena DA, Nunes Ferraz FA, Berti DA, Paschoal Sobreira TJ, Costa-Junior HM, Abdel Baqui MM, Disatnik MH, Xavier-Neto J, Lopes de Oliveira PS, Schechtman D Tags: Sci Signal Source Type: research

PIP4kγ is a substrate for mTORC1 that maintains basal mTORC1 signaling during starvation.
Abstract Phosphatidylinositol-5-phosphate 4-kinases (PIP4ks) are a family of lipid kinases that specifically use phosphatidylinositol 5-monophosphate (PI-5-P) as a substrate to synthesize phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2]. Suppression of PIP4k function in Drosophila results in smaller cells and reduced target of rapamycin complex 1 (TORC1) signaling. We showed that the γ isoform of PIP4k stimulated signaling through mammalian TORC1 (mTORC1). Knockdown of PIP4kγ reduced cell mass in cells in which mTORC1 is constitutively activated by Tsc2 deficiency. In Tsc2 null cells, mTORC1 activation was parti...
Source: Science Signaling - November 8, 2014 Category: Biomedical Science Authors: Mackey AM, Sarkes DA, Bettencourt I, Asara JM, Rameh LE Tags: Sci Signal Source Type: research

Artifact rejection and cycle detection in immature breathing: Application to the early detection of neonatal sepsis
Publication date: February 2015 Source:Biomedical Signal Processing and Control, Volume 16 Author(s): X. Navarro , F. Porée , A. Beuchée , G. Carrault This paper proposes a new framework to obtain quality respiratory variability signals from the raw breathing recorded in neonatal intensive care units (NICUs). It combines three consecutive blocks: an automatic rejection of artifacts, implemented by a logistic regression classifier, a two-step filtering process, and the identification of respiratory cycles, implemented by a peak detection algorithm. By means of a gold standard built from a preterm infants database, the p...
Source: Biomedical Signal Processing and Control - November 8, 2014 Category: Biomedical Science Source Type: research

Monitoring cardiovascular changes due to local anesthesia during and after tooth extraction using pulse wave analysis
Publication date: February 2015 Source:Biomedical Signal Processing and Control, Volume 16 Author(s): S.T. Veerabhadrappa , Anoop Lal Vyas , Sneh Anand , Nagarajappa Das A study was conducted to determine the ongoing short-term changes in pulse waveform and pulse transit time in patients during tooth extraction. The sympathetic stimulation produced during tooth extraction under local anesthesia (LA) utilizing 2% lignocaine with adrenaline is evaluated. The increase in pulse rate due to vasoconstriction in the peripheral blood vessels has been quantifying the sympathetic stimulation to the local anesthesia. The ECG and pu...
Source: Biomedical Signal Processing and Control - November 8, 2014 Category: Biomedical Science Source Type: research

Retinal image registration using topological vascular tree segmentation and bifurcation structures
Publication date: February 2015 Source:Biomedical Signal Processing and Control, Volume 16 Author(s): Li Chen , Xiaotong Huang , Jing Tian This paper presents a new retinal image segmentation and registration approaches. The contribution of this paper is two-fold. First, the conventional vessel-tracking methods use local sequential searching, which can be easily trapped by local intensity discontinuity or vessel rupture. The proposed method uses global graph-based decision that can segment the topological vascular tree with 1-pixel width and fully connection from retinal images. Staring from initial multi-scale ridge seg...
Source: Biomedical Signal Processing and Control - November 8, 2014 Category: Biomedical Science Source Type: research

Online classification algorithm for eye-movement-based communication systems using two temporal EEG sensors
Publication date: February 2015 Source:Biomedical Signal Processing and Control, Volume 16 Author(s): Abdelkader Nasreddine Belkacem , Duk Shin , Hiroyuki Kambara , Natsue Yoshimura , Yasuharu Koike Real-time classification of eye movements offers an effective mode for human–machine interaction, and many eye-based interfaces have been presented in the literature. However, such systems often require that sensors be attached around the eyes, which can be obtrusive and cause discomfort. Here, we used two electroencephalography sensors positioned over the temporal areas to perform real-time classification of eye-blink and ...
Source: Biomedical Signal Processing and Control - November 8, 2014 Category: Biomedical Science Source Type: research

Delineation of malignant skin tumors by hyperspectral imaging using diffusion maps dimensionality reduction
Publication date: February 2015 Source:Biomedical Signal Processing and Control, Volume 16 Author(s): Valery Zheludev , Ilkka Pölönen , Noora Neittaanmäki-Perttu , Amir Averbuch , Pekka Neittaanmäki , Mari Grönroos , Heikki Saari A new non-invasive method for delineation of lentigo maligna and lentigo maligna melanoma is demonstrated. The method is based on the analysis of the hyperspectral images taken in vivo before surgical excision of the lesions. For this, the characteristic features of the spectral signatures of diseased pixels and healthy pixels are extracted, which combine the intensities in a few selected w...
Source: Biomedical Signal Processing and Control - November 8, 2014 Category: Biomedical Science Source Type: research

Stochastic Model Predictive (STOMP) glycaemic control for the intensive care unit: Development and virtual trial validation
Publication date: February 2015 Source:Biomedical Signal Processing and Control, Volume 16 Author(s): Kent W. Stewart , Christopher G. Pretty , Hamish Tomlinson , Liam Fisk , Geoffrey M. Shaw , J. Geoffrey Chase Critically ill patients often experience stress-induced hyperglycaemia, which results in increased morbidity and mortality. Glycaemic control (GC) can be implemented in the intensive care unit (ICU) to safely manage hyperglycaemia. Two protocols SPRINT and STAR, have been implemented in the Christchurch ICU, and have been successful in treating hyperglycaemia while decreasing the risk of hypoglycaemia. This paper...
Source: Biomedical Signal Processing and Control - November 8, 2014 Category: Biomedical Science Source Type: research

Frequency-domain active contours solution to evaluate intima–media thickness of the common carotid artery
Publication date: February 2015 Source:Biomedical Signal Processing and Control, Volume 16 Author(s): M.C. Bastida-Jumilla , R.M. Menchón-Lara , J. Morales-Sánchez , R. Verdú-Monedero , J. Larrey-Ruiz , J.L. Sancho-Gómez The intima–media thickness (IMT) of the common carotid artery (CCA) is being used as a reliable and early detector of atherosclerosis. Atherosclerosis may be unnoticed fo years before triggering severe illnesses such as stroke, embolisms or ischemia. Hence, the use of IMT leads to an early atherosclerosis diagnosis that can prevent more serious cardiovascular diseases. Usually, IMT is manually extr...
Source: Biomedical Signal Processing and Control - November 8, 2014 Category: Biomedical Science Source Type: research

Postprandial response improvement via safety layer in closed-loop blood glucose controllers
Publication date: February 2015 Source:Biomedical Signal Processing and Control, Volume 16 Author(s): Fabian León-Vargas , Fabricio Garelli , Hernán De Battista , Josep Vehí Traditional type 1 diabetes therapies are prone to show poor glucose regulation especially in the postprandial period owing to both physiological and technological limitations. Although a closed-loop controller for glucose regulation has to be tuned to minimize the postprandial excursion and avoid late hypoglycemia, the intrinsic limitations of the problem lead to a trade-off between postprandial peak and late hypoglycemia risk. This paper reveals...
Source: Biomedical Signal Processing and Control - November 8, 2014 Category: Biomedical Science Source Type: research

Resting tremor classification and detection in Parkinson's disease patients
Publication date: February 2015 Source:Biomedical Signal Processing and Control, Volume 16 Author(s): Carmen Camara , Pedro Isasi , Kevin Warwick , Virginie Ruiz , Tipu Aziz , John Stein , Eduard Bakštein Parkinson is a neurodegenerative disease, in which tremor is the main symptom. This paper investigates the use of different classification methods to identify tremors experienced by Parkinsonian patients. Some previous research has focussed tremor analysis on external body signals (e.g., electromyography, accelerometer signals, etc.). Our advantage is that we have access to sub-cortical data, which facilitates the appl...
Source: Biomedical Signal Processing and Control - November 8, 2014 Category: Biomedical Science Source Type: research

Comparison of an audio-based and a video-based approach for detecting diplophonia
Publication date: Available online 8 November 2014 Source:Biomedical Signal Processing and Control Author(s): Philipp Aichinger , Imme Roesner , Matthias Leonhard , Berit Schneider-Stickler , Doris-Maria Denk-Linnert , Wolfgang Bigenzahn , Anna Katharina Fuchs , Martin Hagmüller , Gernot Kubin Background and objectives Diplophonia is a common symptom in voice disorders. Depending on the underlying aetiology, diplophonic patients typically need treatment such as phonosurgery or speech therapy. In current clinical practice, the presence of diplophonia is assessed by auditive rating. To avoid subjectivity in voice assessme...
Source: Biomedical Signal Processing and Control - November 8, 2014 Category: Biomedical Science Source Type: research

Long-chain flavodoxin FldB from Escherichia coli.
PMID: 25380767 [PubMed - as supplied by publisher] (Source: Journal of Bimolecular NMR)
Source: Journal of Bimolecular NMR - November 8, 2014 Category: Biomedical Science Authors: Ye Q, Fu W, Hu Y, Jin C Tags: J Biomol NMR Source Type: research

In vitro assessment of effects of hyperglycemia on the optical properties of blood during coagulation using optical coherence tomography
Abstract No published reports have demonstrated the capability of the optical coherence tomography technique for quantifying the optical coherence tomography signal slope, 1/e light penetration depth, and attenuation coefficient of hyperglycemic blood by an in vitro assessment. The purpose of this study was to investigate the effects of hyperglycemia on optical properties during in vitro blood coagulation by optical coherence tomography. Normal whole blood acted as the control group. After 1-h coagulation, the average optical coherence tomography signal slope decreased approximately 23.3 and 16.7 %, and the 1/e l...
Source: Lasers in Medical Science - November 8, 2014 Category: Laser Surgery Source Type: research

The low level laser therapy (LLLT) operating in 660 nm reduce gene expression of inflammatory mediators in the experimental model of collagenase-induced rat tendinitis
Abstract Tendinopathy is a common disease with a variety of treatments and therapies. Laser therapy appears as an alternative treatment. Here, we investigate the effects of laser irradiation in an experimental model of tendinitis induced by collagenase injection on rats’ Achilles tendon, verifying its action in important inflammatory markers. Male Wistar rats were used and divided into five groups: control saline (C), non-treated tendinitis (NT) and tendinitis treated with sodium diclofenac (D) or laser (1 J) and (3 J). The tendinitis was induced by collagenase (100 μg/tendon) on the Achilles tendon, which w...
Source: Lasers in Medical Science - November 8, 2014 Category: Laser Surgery Source Type: research

3D deep-imaging advance likely to drive new biological insights
In a significant technical advance, a team of neuroscientists at The Rockefeller University has devised a fast, inexpensive imaging method for probing the molecular intricacies of large biological samples in three dimensions, an achievement that could have far reaching implications in a wide array of basic biological investigations. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - November 7, 2014 Category: Biomedical Science Authors: pubaff Tags: Science News iDISCO imaging Laboratory of Brain Development and Repair Marc Tessier-Lavigne neurobiology neuroscience Source Type: news

In vivo and in vitro toxicity of nanogold conjugated snake venom protein toxin GNP-NKCT1
Publication date: 2014 Source:Toxicology Reports, Volume 1 Author(s): Partha Pratim Saha , Tanmoy Bhowmik , Anjan Kumar Dasgupta , Antony Gomes Research on nanoparticles has created interest among the biomedical scientists. Nanoparticle conjugation aims to target drug delivery, increase drug efficacy and imaging for better diagnosis. Toxicity profile of the nanoconjugated molecules has not been studied well. In this communication, the toxicity profile of snake venom cytotoxin (NKCT1), an antileukemic protein toxin, was evaluated after its conjugation with gold nanoparticle (GNP-NKCT1). Gold nanoparticle conjugation with ...
Source: Toxicology Reports - November 7, 2014 Category: Toxicology Source Type: research

Surface Plasmon Mode Coupling in Photonic Crystal Fiber Symmetrically Filled with Ag/Au Alloy Wires
Abstract The surface plasmon mode coupling in photonic crystal fiber filled with Ag/Au alloy wires into two symmetrical cladding air holes have been numerically investigated using the finite element method. For the cases of pure noble metal silver and gold, they exhibit similar polarization characteristics. The coupling strongly depends on the complex indices of the core mode and surface plasmon polaritons mode. Ag/Au alloy decreases the refractive index of surface plasmon mode and significantly increases the loss at longer wavelength. What should be paid a special attention is that there is a surge in loss of y-p...
Source: Plasmonics - November 7, 2014 Category: Biomedical Science Source Type: research

Proteomics as a new paradigm to tackle Parkinson’s disease research challenges
Publication date: December 2014 Source:Translational Proteomics, Volumes 4–5 Author(s): Virginie Licker , Pierre R. Burkhard Disease-modifying therapies capable to stop or slow Parkinson’s disease (PD) progression are still elusive due to severe shortcomings in the understanding of PD etiopathogenesis as well as limitations in routine clinically-based diagnosis precluding PD detection during its early course. Proteomics has recently emerged as one of the most attractive approaches to unravel the complex nature of PD processes and investigate PD potential biomarkers. In contrast to traditional candidate-based studies,...
Source: Translational Proteomics - November 7, 2014 Category: Biomedical Science Source Type: research

The application of multiple reaction monitoring to assess ApoA-I methionine oxidations in diabetes and cardiovascular disease
In this study, we developed an MRM assay to monitor the abundance ratio of the peptide containing oxidized M148 to the native peptide in ApoA-I. Measurement of the oxidized-to-unoxidized-M148 ratio was reproducible (CV<5%). The extent of methionine M148 oxidation in the HDL of healthy controls, and type 2 diabetic participants with and without prior cardiovascular events (CVD) were then examined. The results suggest a significant increase in the relative ratio of the peptide containing oxidized M148 to the unmodified peptide in the HDL of participants with diabetes and CVD (p <0.001), compared to participants...
Source: Translational Proteomics - November 7, 2014 Category: Biomedical Science Source Type: research

Contribution of proteomics to the management of vascular disorders
Publication date: Available online 28 October 2014 Source:Translational Proteomics Author(s): Fernando de la Cuesta , Laura Mourino-Alvarez , Montserrat Baldan-Martin , Rafael Moreno-Luna , Maria G. Barderas Vascular disorders, and in particular atherothrombosis, are currently a leading cause of morbidity and mortality in Western societies. Proteomics research into these disorders has helped improving our knowledge of the underlying mechanisms involved in the development of atherothrombosis, as well as providing novel biomarkers to diagnose and for the prognosis of this disease. However, the application of these advances...
Source: Translational Proteomics - November 7, 2014 Category: Biomedical Science Source Type: research

Platelet proteomics in cardiovascular diseases
Publication date: Available online 7 October 2014 Source:Translational Proteomics Author(s): Paula Vélez , Ángel García In recent years, platelet proteomics has been applied successfully to the study of cardiovascular diseases (CVDs). It is very well known that platelets play a pivotal role in the pathophysiological mechanisms underlying many CVDs, especially acute coronary syndromes (ACSs), since they are implied in thrombus formation after atheroma plaque rupture. This is the reason why molecules involved in platelet activation and aggregation are primary targets for treatment of ACSs. Many efforts are aimed at find...
Source: Translational Proteomics - November 7, 2014 Category: Biomedical Science Source Type: research

Chemokines after human ischemic stroke: From neurovascular unit to blood using protein arrays
Publication date: June 2014 Source:Translational Proteomics, Volume 3 Author(s): Teresa García-Berrocoso , Dolors Giralt , Víctor Llombart , Alejandro Bustamante , Anna Penalba , Alan Flores , Marc Ribó , Carlos A. Molina , Anna Rosell , Joan Montaner Chemokines act mainly in guiding leukocyte migration along the endothelium. Apart from angiogenesis or neuronal survival, chemokines are involved in damage and repair of brain tissue after ischemic stroke. We studied the presence of chemokines directly in neurons and brain blood vessels that were obtained by means of laser microdissection from human ischemic brains. Usin...
Source: Translational Proteomics - November 7, 2014 Category: Biomedical Science Source Type: research

Microwave and magnetic (M2) proteomics of a mouse model of mild traumatic brain injury
Publication date: June 2014 Source:Translational Proteomics, Volume 3 Author(s): Teresa M. Evans , Holly Van Remmen , Anjali Purkar , Swetha Mahesula , J.A.L. Gelfond , Marian Sabia , Wenbo Qi , Ai-Ling Lin , Carlos A. Jaramillo , William E. Haskins Short-term increases in oxidative stress and decreases in motor function, including debilitating effects on balance and motor control, can occur following primary mild traumatic brain injuries (mTBI). However, the long-term effects on motor unit impairment and integrity as well as the molecular mechanisms underlying secondary injuries are poorly understood. We hypothesized th...
Source: Translational Proteomics - November 7, 2014 Category: Biomedical Science Source Type: research

Recent updates on drug abuse analyzed by neuroproteomics studies: Cocaine, Methamphetamine and MDMA
Publication date: Available online 2 May 2014 Source:Translational Proteomics Author(s): Firas Kobeissy , Tarek H. Mouhieddine , Amaly Nokkari , Muhieddine Itani , Mohammed Mouhieddine , Zhiqun Zhang , Rui Zhu , Mark S. Gold , Kevin K. Wang , Yehia Mechref Currently, drug abuse and addiction represent a global public health concern with about 13.6 million people using illicit drugs in the USA alone. Substance abuse intervenes in normal brain functioning, causing alterations in memory, behavior and neuronal physiology. Although many studies have been conducted to elucidate the mode of action of different drugs, the hetero...
Source: Translational Proteomics - November 7, 2014 Category: Biomedical Science Source Type: research

Quality requirements for quantitative clinical chemistry proteomics
Publication date: March 2014 Source:Translational Proteomics, Volume 2 (Source: Translational Proteomics)
Source: Translational Proteomics - November 7, 2014 Category: Biomedical Science Source Type: research

Analysis of plasma from prostate cancer patients links decreased carnosine dipeptidase 1 levels to lymph node metastasis
Publication date: March 2014 Source:Translational Proteomics, Volume 2 Author(s): Ulrika Qundos , Henrik Johannesson , Claudia Fredolini , Gillian O’Hurley , Rui Branca , Mathias Uhlén , Fredrik Wiklund , Anders Bjartell , Peter Nilsson , Jochen M. Schwenk There is a need for a better differentiation of aggressive tumors in prostate cancer to design a tailored treatment for each patient, preferably by a minimally invasive analysis of blood samples. In a previous study, we discovered a decrease of plasma levels of carnosine dipeptidase 1 (CNDP1) in association with aggressive prostate cancer. Now this relation has been...
Source: Translational Proteomics - November 7, 2014 Category: Biomedical Science Source Type: research

Profiling of human myotubes reveals an intrinsic proteomic signature associated with type 2 diabetes
Publication date: March 2014 Source:Translational Proteomics, Volume 2 Author(s): Lubna Al-Khalili , Thais de Castro Barbosa , Jörgen Östling , Julie Massart , Mutsumi Katayama , Ann-Christin Nyström , Jan Oscarsson , Juleen R. Zierath The development of insulin resistance and type 2 diabetes (T2D) involves a complex array of metabolic defects in skeletal muscle. An in vitro cell culture system excludes the acute effects of external systemic factors existing in vivo. Thus, we aimed to determine whether intrinsic differences in the protein profile exist in cultured myotubes derived from T2D versus normal glucose tolera...
Source: Translational Proteomics - November 7, 2014 Category: Biomedical Science Source Type: research

Ultrahigh resolution profiles lead to more detailed serum peptidome signatures of pancreatic cancer
Publication date: March 2014 Source:Translational Proteomics, Volume 2 Author(s): Simone Nicolardi , Berit Velstra , Bart J. Mertens , Bert Bonsing , Wilma E. Mesker , Rob A.E.M. Tollenaar , André M. Deelder , Yuri E.M. van der Burgt Mass spectrometry-based (clinical) proteomics has been widely applied as a technology to find and validate disease-specific protein signatures. MALDI-based peptidome profiles provide a suitable platform for classification of body fluids or tissues, albeit at the cost of being unable to observe low abundant species. Here we show that a fully automated one-step solid-phase extraction serum sa...
Source: Translational Proteomics - November 7, 2014 Category: Biomedical Science Source Type: research

Reverse phase protein array based tumor profiling identifies a biomarker signature for risk classification of hormone receptor-positive breast cancer
In conclusion, the biomarker signature introduced supports RPPA as a tool for cancer biomarker discovery. Graphical abstract (Source: Translational Proteomics)
Source: Translational Proteomics - November 7, 2014 Category: Biomedical Science Source Type: research

Molecular mechanisms of increased cerebral vulnerability after repeated mild blast-induced traumatic brain injury
Publication date: Available online 2 December 2013 Source:Translational Proteomics Author(s): Alaa Kamnaksh , Farid Ahmed , Erzsebet Kovesdi , Erin S. Barry , Neil E. Grunberg , Joseph B. Long , Denes V. Agoston The consequences of a mild traumatic brain injury can be especially severe if it is repeated within the period of increased cerebral vulnerability (ICV) that follows the initial insult. To better understand the molecular mechanisms that contribute to ICV, we exposed rats to different levels of mild blast overpressure (5 exposures; total pressure range: 15.54–19.41psi or 107.14–133.83kPa) at a rate of 1 per 30...
Source: Translational Proteomics - November 7, 2014 Category: Biomedical Science Source Type: research

The art of proteomics translation
Publication date: 2013 Source:Translational Proteomics, Volume 1, Issue 1 Author(s): Jean-Charles Sanchez (Source: Translational Proteomics)
Source: Translational Proteomics - November 7, 2014 Category: Biomedical Science Source Type: research

Is clinical proteomics heading towards to “bench to bedside”?
Publication date: 2013 Source:Translational Proteomics, Volume 1, Issue 1 (Source: Translational Proteomics)
Source: Translational Proteomics - November 7, 2014 Category: Biomedical Science Source Type: research

PanelomiX: A threshold-based algorithm to create panels of biomarkers
In conclusion, the PanelomiX toolbox combines biomarkers and evaluates the performance of panels to classify patients better than single markers or other classifiers. The ICBT algorithm proved to be an efficient classifier, the results of which can easily be interpreted. Graphical abstract (Source: Translational Proteomics)
Source: Translational Proteomics - November 7, 2014 Category: Biomedical Science Source Type: research

The Human Diabetes Proteome Project (HDPP): From network biology to targets for therapies and prevention
Publication date: 2013 Source:Translational Proteomics, Volume 1, Issue 1 Author(s): F. Topf , D. Schvartz , P. Gaudet , F. Priego-Capote , A. Zufferey , N. Turck , P.-A. Binz , P. Fontana , A. Wiederkehr , F. Finamore , I. Xenarios , D. Goodlett , M. Kussmann , P. Bergsten , J.-C. Sanchez Type 2 diabetes is a worldwide disease reaching epidemic dimensions. The rapid progression of the disease urgently calls for both a broader and deeper understanding of its pathophysiology. In line with this statement, the Human Diabetes Proteome Project (HDPP) was officially launched at the 11th HUPO meeting in Boston, 2012. A special ...
Source: Translational Proteomics - November 7, 2014 Category: Biomedical Science Source Type: research

Translation of human African trypanosomiasis biomarkers towards field application
Publication date: 2013 Source:Translational Proteomics, Volume 1, Issue 1 Author(s): Natalia Tiberti , Alexandre Hainard , Jean-Charles Sanchez Sleeping sickness is a neglected tropical disease affecting rural communities in sub-Saharan Africa. The reduction in the number of reported cases in recent years indicates that disease transmission is under control. However, many aspects of patient management still need to be improved. Undiagnosed patients or inappropriate treatment due to an incorrect determination of the disease stage could in fact lead to its re-emergence. There is thus a strong need for new diagnostic and st...
Source: Translational Proteomics - November 7, 2014 Category: Biomedical Science Source Type: research