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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 9.

Proceedings of the National Academy of Sciences USA 111: 3614-3619 (14-3-4)
Proceedings of the National Academy of Sciences USA 111: 3614-3619 Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+ channels Stephen G. Brohawn, Zhenwei Su and Roderick MacKinnon (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - March 4, 2014 Category: Biomedical Science Authors: pubaff Tags: Research Update Source Type: news

Functional analysis of the rabbit temporomandibular joint using dynamic biplane imaging
The objective of this study was to evaluate and determine repeatable measurements of rabbit TMJ kinematics. Maximal distances, as well as paths were traced and analyzed for the incisors and for the condyle–fossa relationship. From one rabbit to another, the rotations and translations of both the incisors and the condyle relative to the fossa contained multiple clear, repeatable patterns. The slope of the superior/inferior incisor distance with respect to the rotation about the transverse axis was repeatable to 0.14mm/deg and the right/left incisor distance with respect to the rotation about the vertical axis was repeatab...
Source: Journal of Biomechanics - March 4, 2014 Category: Biomedical Science Authors: Sarah E. Henderson, Riddhi Desai, Scott Tashman, Alejandro J. Almarza Tags: Papers Source Type: research

Regulatory mechanism of performance in chronic cognitive fatigue
Abstract: Chronic cognitive fatigue is characterized by a sensation of long-lasting fatigue that impairs cognitive functions. Facilitation and inhibition systems in the central nervous system play primary roles in determining the output to the peripheral system, that is, performance. Sensory input from the peripheral system to the central nervous system activates the inhibition system to limit performance, whereas motivational input activates the facilitation system to enhance performance. The dysfunction of the facilitation system and central sensitization and classical conditioning of the inhibition system play important...
Source: Medical Hypotheses - March 4, 2014 Category: Biomedical Science Authors: Masaaki Tanaka, Akira Ishii, Yasuyoshi Watanabe Tags: Articles Source Type: research

Adjunct faculty member Kayo Inaba receives L’Oréal-UNESCO Women in Science award
Inaba, a member of Michel Nussenzweig’s Laboratory of Molecular Immunology who previously worked in Ralph Steinman’s lab, is known for her work on specialized immune cells called dendritic cells. Inaba is being honored as the Asia-Pacific recipient of the L’Oréal-UNESCO Women in Science award, which supports eminent women in science throughout the world who are working in life and physical sciences. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - March 3, 2014 Category: Biomedical Science Authors: pubaff Tags: Awards and Honors dendritic cells Kayo Inaba L'Oréal-UNESCO prize Michel C. Nussenzweig Source Type: news

Elaine Fuchs receives prestigious award from American Association for Cancer Research
Fuchs is being recognized with the 2014 Pezcoller Foundation-AACR International Award for Cancer Research for her contributions to the understanding of skin, skin stem cells and skin-related disease. Fuchs is highly regarded for her studies using reverse genetics to understand the biological basis of normal and abnormal skin development and function. The award, now in its 17th year, recognizes an individual scientist of international renown who has made a major scientific discovery in basic or translational cancer research. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - March 3, 2014 Category: Biomedical Science Authors: pubaff Tags: Awards and Honors American Association for Cancer Research Elaine Fuchs Pezcoller Source Type: news

Title page/Editorial Board
(Source: Medical Hypotheses)
Source: Medical Hypotheses - March 3, 2014 Category: Biomedical Science Source Type: research

Proceedings of the National Academy of Sciences USA online: March 3, 2014
microRNAs are biomarkers of oncogenic human papillomavirus infections Xiaohong Wang, Hsu-Kun Wang, Yang Li, Markus Hafner, Nilam Sanjib  Banerjee, Shuang Tang, Daniel Briskin, Craig Meyers, Louise T. Chow, … More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - March 3, 2014 Category: Biomedical Science Authors: pubaff Tags: Research Update Source Type: news

Current Biology 24: 494-508 (14-3-3)
Current Biology 24: 494-508 FLRT3 is a robo1-interacting protein that determines netrin-1 attraction in developing axons Eduardo Leyva-Díaz, Daniel del Toro, Maria José Menal, Serafi Cambray, Rafael Susín, Marc Tessier-Lavigne, Rüdiger Klein, Joaquim Egea and Guillermina López-Bendito (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - March 3, 2014 Category: Biomedical Science Authors: pubaff Tags: Research Update Source Type: news

Editorial Board and Publication Information
(Source: Journal of Biomechanics)
Source: Journal of Biomechanics - March 3, 2014 Category: Biomedical Science Source Type: research

Plaque mechanics
The deformation and stress distribution in plaques play an important role in various aspects of atherosclerotic disease. This special issue is composed of reviews and original research articles of the state-of-the-art, focusing on different topics that relate to plaque mechanics. These articles, which represent a snapshot of the cutting edge research currently conducted in this area, were contributed by leading groups in the field. (Source: Journal of Biomechanics)
Source: Journal of Biomechanics - March 3, 2014 Category: Biomedical Science Authors: Frank J.H. Gijsen, Francesco Migliavacca Source Type: research

Angiotensin 1-7/Mas-1 axis attenuates the expression and signaling of TGF-{beta}1 induced by Angiotensin II in skeletal muscle
In this study, we tested if angiotensin 1-7 (Ang 1-7), through the Mas-1 receptor, can counteract the signaling induced by Ang-II in skeletal muscle causing a decrease in the expression and further activity of TGF-β1 in skeletal muscle cells. Our results show that Ang 1-7 decreases the expression of TGF-β1 induced by Ang-II in a dose-dependent manner. In addition, we observed that Ang 1-7 prevents the increase of TGF-β1 expression induced by Ang-II, ROS production dependent on NOX, and early p38 MAPK phosphorylation. Interestingly, Ang 1-7 also prevents late p38 MAPK phosphorylation, Smad-2 phosphoryl...
Source: Clinical Science - March 3, 2014 Category: Biomedical Science Authors: M Morales, J Abrigo, C Meneses, F Simon, F Cisternas, J Rivera, Y Vazquez, C Cabello-Verrugio Source Type: research

Comparative study on effects of single and multiple oral administration of mungbean (Phaseolus radiatus L.) seed extract on the pharmacokinetics of aconitine by UHPLC-MS.
Abstract The study was aimed to investigate the effects of single and multiple oral administration of mungbean (Phaseolus radiatus L.) seed extract (ME) on the pharmacokinetics of aconitine in rats. The Sprague-Dawley rats were randomly divided into three groups (six rats each group). In group 1, rats were orally administered 500 µg/kg aconitine after receiving a single oral dose of 1 g/kg ME. In group 2, rats were orally administered with 500 µg/kg aconitine at day 7 of treatment with 1 g/kg/day ME. In group 3, rats were orally administered with 500 µg/kg aconitine. Blood samples were collected at dif...
Source: Biomedical Chromatography : BMC - March 3, 2014 Category: Biomedical Science Authors: Gao E, Yu X, Liu T, Li H, Wang P, Wei Y, Zhao Y, Yu Z Tags: Biomed Chromatogr Source Type: research

Randomized two-way cross-over bioequivalence study of two amoxicillin formulations and inter-ethnicity pharmacokinetic variation in healthy Malay volunteers.
The objectives of this study were to develop a new deproteinization method to extract amoxicillin from human plasma and evaluate the inter-ethnic variation of amoxicillin pharmacokinetics in healthy Malay volunteers. A single-dose, randomized, fasting, two-period, two-treatment, two-sequence crossover, open-label bioequivalence study was conducted in 18 healthy Malay adult male volunteers, with one week washout period. The drug concentration in the sample was analyzed using high-performance liquid chromatography (UV-vis HPLC). The mean (standard deviation) pharmacokinetic parameter results of Moxilen® were: peak concentra...
Source: Biomedical Chromatography : BMC - March 3, 2014 Category: Biomedical Science Authors: Liew KB, Loh GO, Tan YT, Peh KK Tags: Biomed Chromatogr Source Type: research

Reduced bioenergetics and toll-like receptor 1 function in human polymorphonuclear leukocytes in aging.
Abstract Aging is associated with a progressive decline in immune function (immunosenescence) resulting in an increased susceptibility to viral and bacterial infections. Here we show reduced expression of Toll-like receptor 1 (TLR1) in polymorphonuclear leukocytes (PMN) and an underlying age-dependent deficiency in PMN bioenergetics. In older (>65 years) adults, stimulation through TLR1 led to lower activation of integrins (CD11b and CD18), lower production of the chemokine IL-8, and lower levels of the phosphorylated signaling intermediate p38 MAP kinase than in PMN from younger donors (21-30 years). In additio...
Source: Aging - March 3, 2014 Category: Biomedical Science Authors: Qian F, Guo X, Wang X, Yuan X, Chen S, Malawista SE, Bockenstedt LK, Allore HG, Montgomery RR Tags: Aging (Albany NY) Source Type: research

Quantitative evaluation of the major determinants of human gait
Abstract: Accurate knowledge of the isolated contributions of joint movements to the three-dimensional displacement of the center of mass (COM) is fundamental for understanding the kinematics of normal walking and for improving the treatment of gait disabilities. identified six kinematic mechanisms to explain the efficient progression of the whole-body COM in the sagittal, transverse, and coronal planes. These mechanisms, referred to as the major determinants of gait, were pelvic rotation, pelvic list, stance knee flexion, foot and knee mechanisms, and hip adduction. The aim of the present study was to quantitatively asses...
Source: Journal of Biomechanics - March 3, 2014 Category: Biomedical Science Authors: Yi-Chung Lin, Margit Gfoehler, Marcus G. Pandy Tags: Papers Source Type: research

Required coefficient of friction during turning at self-selected slow, normal, and fast walking speeds
This study investigated the relationship of required coefficient of friction to gait speed, obstacle height, and turning strategy as participants walked around obstacles of various heights. Ten healthy, young adults performed 90° turns around corner pylons of four different heights at their self selected normal, slow, and fast walking speeds using both step and spin turning strategies. Kinetic data was captured using force plates. Results showed peak required coefficient of friction (RCOF) at push off increased with increased speed (slow μ=0.38, normal μ=0.45, and fast μ=0.54). Obstacle height had no effect on RCOF val...
Source: Journal of Biomechanics - March 3, 2014 Category: Biomedical Science Authors: Peter Fino, Thurmon E. Lockhart Tags: Papers Source Type: research

Selective lateral muscle activation in moderate medial knee osteoarthritis subjects does not unload medial knee condyle
Abstract: There is some debate in the literature regarding the role of quadriceps-hamstrings co-contraction in the onset and progression of knee osteoarthritis. Does co-contraction during walking increase knee contact loads, thereby causing knee osteoarthritis, or might it be a compensatory mechanism to unload the medial tibial condyle? We used a detailed musculoskeletal model of the lower limb to test the hypothesis that selective activation of lateral hamstrings and quadriceps, in conjunction with inhibited medial gastrocnemius, can actually reduce the joint contact force on the medial compartment of the knee, independen...
Source: Journal of Biomechanics - March 3, 2014 Category: Biomedical Science Authors: Scott C.E. Brandon, Ross H. Miller, Darryl G. Thelen, Kevin J. Deluzio Tags: Papers Source Type: research

Post-mortem timing of skeletal muscle biochemical and mechanical degradation
Abstract: Fresh cadaveric human tissue is a valuable resource that is used to address important clinical questions. However, it is unknown how post-mortem time impacts skeletal muscle mechanical and biochemical properties. We simulated morgue conditions in rabbits and tested the passive mechanical properties of muscle bundles, and the degradation of myosin heavy chain, collagen, and titin at specific intervals up to 7 days post-mortem. While a great deal of inter-specimen variability was observed, it was independent of post-mortem time. Passive mechanics, myosin heavy chain, and collagen content were all unaffected while t...
Source: Journal of Biomechanics - March 3, 2014 Category: Biomedical Science Authors: Lori J. Tuttle, Marianna Alperin, Richard L. Lieber Tags: Short Communcations Source Type: research

Energy exchange between subject and belt during treadmill walking
Abstract: Treadmill walking aims to simulate overground walking, but intra-stride belt speed variations of treadmills result in some interaction between treadmill and subject, possibly obstructing this aim. Especially in self-paced treadmill walking, in which the belt speed constantly adjusts to the subject, these interactions might affect the gait pattern significantly. The aim of this study was to quantify the energy exchange between subject and treadmill, during the fixed speed (FS) and self-paced (SP) modes of treadmill walking. Eighteen subjects walked on a dual-belt instrumented treadmill at both modes. The energy ex...
Source: Journal of Biomechanics - March 3, 2014 Category: Biomedical Science Authors: L.H. Sloot, M.M. van der Krogt, J. Harlaar Tags: Short Communcations Source Type: research

Effect of non-uniform thickness of samples in stress relaxation tests under unconfined compression of samples of articular discs
Abstract: A precise information of the biomechanical properties of soft tissues is required to develop a suitable simulation model, with which the distribution of stress and strain in the complex structures can be estimated. Many soft tissues have been mechanically characterized by stress relaxation tests under unconfined or confined compression. In general, full-thickness samples are extracted to reduce the damage in the tissue as much as possible. However, it is not guaranteed that these samples have a uniform thickness or, in other words, planar parallel faces. In particular, in the articular disc of the temporomandibul...
Source: Journal of Biomechanics - March 3, 2014 Category: Biomedical Science Authors: Maria S. Commisso, Javier Martínez-Reina, Juana Mayo, Jaime Domínguez, Eiji Tanaka Tags: Short Communcations Source Type: research

A noninvasive approach to determine viscoelastic properties of an individual adherent cell under fluid flow
In this study, techniques of fluid–structure interaction (FSI) finite element method and quasi-3-dimensional (quasi-3D) cell microscopy were innovatively applied to the frequently used flow chamber experiment, where an adherent cell was subjected to fluid flow. A new non-invasive approach, with cells at close to physiological conditions, was established to determine the viscoelastic properties of individual cells. The results showed an instantaneous modulus of osteocytes of 0.49±0.11kPa, an equilibrium modulus of 0.31±0.044kPa, and an apparent viscosity coefficient of 4.07±1.23kPas. This new quantitative approach not ...
Source: Journal of Biomechanics - March 3, 2014 Category: Biomedical Science Authors: Jun Qiu, Andrew D. Baik, X. Lucas Lu, Elizabeth M.C. Hillman, Zhuo Zhuang, Cheng Dong, X. Edward Guo Tags: Short Communcations Source Type: research

Non-destructive assessment of human ribs mechanical properties using quantitative ultrasound
Abstract: Advanced finite element models of the thorax have been developed to study, for example, the effects of car crashes. While there is a need for material properties to parameterize such models, specific properties are largely missing. Non-destructive techniques applicable in vivo would, therefore, be of interest to support further development of thorax models. The only non-destructive technique available today to derive rib bone properties would be based on quantitative computed tomography that measures bone mineral density. However, this approach is limited by the radiation dose. Bidirectional ultrasound axial tran...
Source: Journal of Biomechanics - March 3, 2014 Category: Biomedical Science Authors: David Mitton, Jean-Gabriel Minonzio, Maryline Talmant, Rafaa Ellouz, Frédéric Rongieras, Pascal Laugier, Karine Bruyère-Garnier Tags: Short Communcations Source Type: research

Prevention of cerebral palsy, autism spectrum disorder, and attention deficit – Hyperactivity disorder
Abstract: This hypothesis states that cerebral palsy (CP), autism spectrum disorder (ASD), and attention-deficit/hyperactivity disorder (ADHD) are all caused by an exaggerated central nervous system inflammatory response to a prenatal insult. This prenatal insult may be one or more episodes of ischemia–reperfusion, an infectious disease of the mother or the fetus, or other causes of maternal inflammation such as allergy or autoimmune disease. The resultant fetal inflammatory hyper-response injures susceptible neurons in the developing white matter of the brain in specific areas at specific gestational ages. The exaggerat...
Source: Medical Hypotheses - March 3, 2014 Category: Biomedical Science Authors: Alan D. Strickland Tags: Articles Source Type: research

Alterations in brain temperatures as a possible cause of migraine headache
Abstract: Migraine is a debilitating disease with a recurring generally unilateral headache and concomitant symptoms of nausea, vomiting and photo- and/or phonophobia that affects some 11–18% of the population. Most of the mechanisms previously put forward to explain the attacks have been questioned or give an explanation only some of the symptoms. Moreover, the best drugs for treatment are still the 20-year-old triptans, which have serious limitations as regards both efficacy and tolerability. As the dura and some cranial vessels are the only intracranial structures capable of pain sensations, a vascular theory of migra...
Source: Medical Hypotheses - March 3, 2014 Category: Biomedical Science Authors: Csilla Horváth Tags: Articles Source Type: research

Glaucoma – Diabetes of the brain: A radical hypothesis about its nature and pathogenesis
Abstract: Glaucoma is the leading cause of irreversible blindness characterized by irremediable loss of retinal ganglion cells. Its risk increases with progressing age and elevated intraocular pressure. Studies have established that glaucoma is a neurodegenerative disorder in which the damage involves many brain tissues from retina to the lateral geniculate nucleus. Despite lot of research, complete pathomechanism of glaucoma is not known and there is no treatment available except modification of intraocular pressure pharmacologically and/or surgically. We here present a hypothesis inspired by studies across many areas of ...
Source: Medical Hypotheses - March 3, 2014 Category: Biomedical Science Authors: Muneeb A. Faiq, Rima Dada, Daman Saluja, Tanuj Dada Tags: Articles Source Type: research

The putative role of proteolytic pathways in the pathogenesis of Type 1 diabetes mellitus: The ‘autophagy’ hypothesis
Abstract: Autoimmune diseases are a heterogeneous group of disorders affecting different organs and tissues. New tools, such as genome-wide association studies, have provided evidence for new susceptibility loci and candidate genes in the disease process including common susceptibility genes involved in the immunological synapse and T cell activation. Close linkages have been found in a number of diseases, including ankylosing spondylitis, multiple sclerosis, Crohn’s disease and insulin-dependent diabetes mellitus (Type 1 diabetes mellitus). Evidence for some association with Type 1 diabetes was previously found in the r...
Source: Medical Hypotheses - March 3, 2014 Category: Biomedical Science Authors: Alessandra Fierabracci Tags: Articles Source Type: research

Fatty acid profiles among the Inuit of Nunavik: Current status and temporal change
Abstract: The Inuit undergo substantial changes in their lifestyle, but few data exist on how these changes occur in biomarkers, such as polyunsaturated fatty acids (PUFAs). Here, we report data from a cross-sectional survey conducted in 2004 among 861 representative Nunavik Inuit adults, in whom FAs were measured in red blood cells (RBCs). FAs were also measured in plasma phospholipids (n=452) to assess temporal trend by comparing plasma PUFAs measured in 1992. Food intakes were estimated using a validated food frequency questionnaire. In 2004, marine food intake was 84±4g/d (±SEM). Adjusted-mean of RBC omega-3 was sign...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - March 3, 2014 Category: Biomedical Science Authors: Françoise Proust, Michel Lucas, Éric E. Dewailly Tags: Original articles Source Type: research

Lipid accumulation is ahead of epithelial-to-mesenchymal transition and therapeutic intervention by acetyl-CoA carboxylase 2 silence in diabetic nephropathy
Conclusion: The progress of lipotoxicity participates in the development of diabetic nephropathy in early stage before EMT. The manipulation of lipid metabolism might act as a promising therapeutic intervention for diabetic nephropathy. (Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - March 3, 2014 Category: Biomedical Science Authors: Ying Xu, Jing Huang, Wei Xin, Liyong Chen, Xu Zhao, Zhimei Lv, Yi Liu, Qiang Wan Tags: Basic Science Source Type: research

Our medical science is in rude health
Telegraph View: A breakthrough in stem cell development is evidence of how inventive we are in Britain     (Source: Telegraph Health)
Source: Telegraph Health - March 2, 2014 Category: Consumer Health News Source Type: news

Our medical science is in rude health
Telegraph View: A breakthrough in stem cell development is evidence of how inventive we are in Britain     (Source: The Telegraph : Health Advice)
Source: The Telegraph : Health Advice - March 2, 2014 Category: Consumer Health Advice Source Type: news

Computational modelling of emboli travel trajectories in cerebral arteries: influence of microembolic particle size and density.
Abstract Ischaemic stroke is responsible for up to 80 % of stroke cases. Prevention of the reoccurrence of ischaemic attack or stroke for patients who survived the first symptoms is the major treatment target. Accurate diagnosis of the emboli source for a specific infarction lesion is very important for a better treatment for the patient. However, due to the complex blood flow patterns in the cerebral arterial network, little is known so far of the embolic particle flow trajectory and its behaviour in such a complex flow field. The present study aims to study the trajectories of embolic particles released from car...
Source: Biomechanics and Modeling in Mechanobiology - March 2, 2014 Category: Biomedical Science Authors: Fabbri D, Long Q, Das S, Pinelli M Tags: Biomech Model Mechanobiol Source Type: research

Hypothalamic-mediated control of glucose balance in the presence and absence of insulin.
Abstract Diabetes afflicts hundreds of millions worldwide. People affected by type 1 diabetes mellitus (T1DM; the insulin-deficient form of diabetes) or type 2 diabetes mellitus (T2DM; the insulin-resistant form of diabetes) have significantly reduced life expectancy compared to normal individuals. This is due in part to the fact that (despite improvements) current anti-diabetic approaches are suboptimal. Indeed, severe morbidities (e.g.: cardiovascular disease, hypertension) are still too often associated with diabetes. Recent preclinical results indicate that different types of hypothalamic neurons are endowed wi...
Source: Aging - March 2, 2014 Category: Biomedical Science Authors: Fujikawa T, Coppari R Tags: Aging (Albany NY) Source Type: research

Yeast osmosensors hkr1 and msb2 activate the hog1 MAPK cascade by different mechanisms.
Abstract To cope with environmental high osmolarity, the budding yeast Saccharomyces cerevisiae activates the mitogen-activated protein kinase (MAPK) Hog1, which controls an array of osmoadaptive responses. Two independent, but functionally redundant, osmosensing systems involving the transmembrane sensor histidine kinase Sln1 or the tetraspanning membrane protein Sho1 stimulate the Hog1 MAPK cascade. Furthermore, the Sho1 signaling branch itself also involves the two functionally redundant osmosensors Hkr1 and Msb2. However, any single osmosensor (Sln1, Hkr1, or Msb2) is sufficient for osmoadaptation. We found tha...
Source: Science Signaling - March 1, 2014 Category: Biomedical Science Authors: Tanaka K, Tatebayashi K, Nishimura A, Yamamoto K, Yang HY, Saito H Tags: Sci Signal Source Type: research

Tumor Necrosis Factor Suppresses NR5A2 Activity and Intestinal Glucocorticoid Synthesis to Sustain Chronic Colitis.
Abstract Intestinal crypt epithelial cells synthesize glucocorticoids, steroid hormones that protect against inflammatory bowel disease. To investigate how intestinal glucocorticoids are regulated during chronic inflammation, we induced chronic colitis in mice by exposing them to the chemical dextran sulfate sodium (DSS). We found that intestinal glucocorticoid secretion and expression of the genes Cyp11a1 and Cyp11b1 (which encode enzymes that synthesize glucocorticoids) were initially stimulated, but declined during the chronic phase, whereas tumor necrosis factor (TNF) and inflammatory cytokines secreted by T he...
Source: Science Signaling - March 1, 2014 Category: Biomedical Science Authors: Huang SC, Lee CT, Chung BC Tags: Sci Signal Source Type: research

Arginine Methylation of CRTC2 Is Critical in the Transcriptional Control of Hepatic Glucose Metabolism.
Abstract Fasting glucose homeostasis is maintained in part through cAMP (adenosine 3',5'-monophosphate)-dependent transcriptional control of hepatic gluconeogenesis by the transcription factor CREB (cAMP response element-binding protein) and its coactivator CRTC2 (CREB-regulated transcriptional coactivator 2). We showed that PRMT6 (protein arginine methyltransferase 6) promotes fasting-induced transcriptional activation of the gluconeogenic program involving CRTC2. Mass spectrometric analysis indicated that PRMT6 associated with CRTC2. In cells, PRMT6 mediated asymmetric dimethylation of multiple arginine residues ...
Source: Science Signaling - March 1, 2014 Category: Biomedical Science Authors: Han HS, Jung CY, Yoon YS, Choi S, Choi D, Kang G, Park KG, Kim ST, Koo SH Tags: Sci Signal Source Type: research

mTORC1 Promotes Denervation-Induced Muscle Atrophy Through a Mechanism Involving the Activation of FoxO and E3 Ubiquitin Ligases.
Abstract Skeletal muscle mass and function are regulated by motor innervation, and denervation results in muscle atrophy. The activity of mammalian target of rapamycin complex 1 (mTORC1) is substantially increased in denervated muscle, but its regulatory role in denervation-induced atrophy remains unclear. At early stages after denervation of skeletal muscle, a pathway involving class II histone deacetylases and the transcription factor myogenin mediates denervation-induced muscle atrophy. We found that at later stages after denervation of fast-twitch muscle, activation of mTORC1 contributed to atrophy and that den...
Source: Science Signaling - March 1, 2014 Category: Biomedical Science Authors: Tang H, Inoki K, Lee M, Wright E, Khuong A, Khuong A, Sugiarto S, Garner M, Paik J, Depinho RA, Goldman D, Guan KL, Shrager JB Tags: Sci Signal Source Type: research

The summer premedical program for matriculating medical students: a student-led initiative
In conclusion, this is the first report, to our knowledge, that describes a program developed by senior medical students to improve the experience of freshmen. (Source: AJP: Advances in Physiology Education)
Source: AJP: Advances in Physiology Education - March 1, 2014 Category: Universities & Medical Training Authors: Awad, A. M., AlAmodi, A. A., Shareef, M. A., Alsheikh, A. J., Mahmoud, A. I., Daghistany, A. O., Hijazi, M. M., Abu-Zaid, A., Alsadoon, M., Shabllout, M., Rasool, A., Yaqinuddin, A. Tags: HOW WE TEACH Source Type: research

Anatomic and clinical pathology boot camps: filling pathology-specific gaps in undergraduate medical education.
Conclusions.-Boot camps have 2 purposes: (1) to teach or strengthen knowledge required to practice pathology and (2) to introduce basic skills and processes that will be used during the practitioner's career. PMID: 24576025 [PubMed - in process] (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - March 1, 2014 Category: Laboratory Medicine Authors: Naritoku WY, Vasovic L, Steinberg JJ, Prystowsky MB, Powell SZ Tags: Arch Pathol Lab Med Source Type: research

BSH-CP based 3D solid-state NMR experiments for protein resonance assignment.
Abstract We have recently presented band-selective homonuclear cross-polarization (BSH-CP) as an efficient method for CO-CA transfer in deuterated as well as protonated solid proteins. Here we show how the BSH-CP CO-CA transfer block can be incorporated in a set of three-dimensional (3D) solid-state NMR (ssNMR) pulse schemes tailored for resonance assignment of proteins at high static magnetic fields and moderate magic-angle spinning rates. Due to the achieved excellent transfer efficiency of 33 % for BSH-CP, a complete set of 3D spectra needed for unambiguous resonance assignment could be rapidly recorded within ...
Source: Journal of Bimolecular NMR - March 1, 2014 Category: Biomedical Science Authors: Shi C, Fasshuber HK, Chevelkov V, Xiang S, Habenstein B, Vasa SK, Becker S, Lange A Tags: J Biomol NMR Source Type: research

The summer premedical program for matriculating medical students: a student-led initiative.
In conclusion, this is the first report, to our knowledge, that describes a program developed by senior medical students to improve the experience of freshmen. PMID: 24585471 [PubMed - in process] (Source: Advances in Physiology Education)
Source: Advances in Physiology Education - March 1, 2014 Category: Physiology Authors: Awad AM, Alamodi AA, Shareef MA, Alsheikh AJ, Mahmoud AI, Daghistany AO, Hijazi MM, Abu-Zaid A, Alsadoon M, Shabllout M, Rasool A, Yaqinuddin A Tags: Adv Physiol Educ Source Type: research

Principles of gastrointestinal endoscopy
This article provides an overview of rigid and flexible endoluminal endoscopy, focussing on the common examinations of the GI tract, namely oesophagogastroduodenoscopy (OGD), sigmoidoscopy and colonoscopy. Laparoscopy, the most common form of rigid endoscopy, is discussed elsewhere in this series. (Source: Surgery (Medicine Publishing))
Source: Surgery (Medicine Publishing) - March 1, 2014 Category: Surgery Authors: Tatiana Martin, Kat Schwab, Sukhpal Singh Tags: Basic skills Source Type: research

Preparing individual patient data from clinical trials for sharing: the GlaxoSmithKline approach
This article describes the approach we have taken to prepare data for sharing with other researchers in a way that minimises risk with respect to the privacy and confidentiality of research participants, ensures compliance with current data privacy legal requirements and yet retains utility of the anonymised datasets for research purposes. We recognise that there are different possible approaches and that broad consensus is needed. Copyright © 2014 John Wiley & Sons, Ltd. (Source: Pharmaceutical Statistics)
Source: Pharmaceutical Statistics - March 1, 2014 Category: Statistics Authors: Sara Hughes, Karen Wells, Paul McSorley, Andrew Freeman Tags: Main Paper Source Type: research

Urbanization and workers' compensation in china from 1995 to 2012.
Abstract In order to determine the trend in the number of employees covered by workers' compensation (WC) and trends in the burdens and benefits of WC, and to discuss the possible factors that might influence those trends. A relevant national statistical data from 1995 to 2012 are collected and analyzed. In the results, we found that the proportion of employees covered by WC to total employees in urban areas increased from 13.7% in 1995 to 51.2% in 2012 and also exhibited a significant degree of polarization. In 2012, 27.3% of the peasant workers were covered by WC, which accounted for 37.8% of the total employees ...
Source: Biomedical and Environmental Sciences : BES - March 1, 2014 Category: Biomedical Science Authors: Wang HQ, Li T Tags: Biomed Environ Sci Source Type: research

S Phase Cell Percentage Normalized BrdU Incorporation Rate, a New Parameter for Determining S Arrest.
In conclusion, SFN-BrdU incorporation rate can be used to detecting S arrest. PMID: 24709104 [PubMed - in process] (Source: Biomedical and Environmental Sciences : BES)
Source: Biomedical and Environmental Sciences : BES - March 1, 2014 Category: Biomedical Science Authors: Zhao P, Fu JL, Yao BY, Jia YR, Zhou ZC Tags: Biomed Environ Sci Source Type: research

The Role of ROS in Hydroquinone-induced Inhibition of K562 Cell Erythroid Differentiation.
Abstract The role of ROS in hydroquinone-induced inhibition of K562 cell erythroid differentiation was investigated. After K562 cells were treated with hydroquinone for 24 h, and hemin was later added to induce erythroid differentiation for 48 h, hydroquinone inhibited hemin-induced hemoglobin synthesis and mRNA expression of γ-globin in K562 cells in a concentration-dependent manner. The 24-h exposure to hydroquinone also caused a concentration-dependent increase at an intracellular ROS level, while the presence of N- acetyl-L-cysteine prevented hydroquinone- induced ROS production in K562 cells. The presence of ...
Source: Biomedical and Environmental Sciences : BES - March 1, 2014 Category: Biomedical Science Authors: Yu CH, Suriguga, Li Y, Li YR, Tang KY, Jiang L, Yi ZC Tags: Biomed Environ Sci Source Type: research

Nickel-exposed Workers in China: A Cohort Study.
Abstract There are more than 50 000 workers in Jinchuan Group Co, Ltd (JNMC). Since all staff in JNMC are eligible for a medical examination every two years, only 23 484 nickel-exposed subjects who participated in medical examination were included in this study. Their data, collected from June 22, 2011 to September 28, 2012, in a comprehensive epidemiological survey and during medical examinations, permitted an extensive evaluation of the relation between metal exposure, gene, epigenetics and risk of human diseases. Their lifestyle investigation showed that the overall prevalence of current smokers, alcohol drinker...
Source: Biomedical and Environmental Sciences : BES - March 1, 2014 Category: Biomedical Science Authors: Bai YN, Yagn AM, Pu HQ, He J, Cheng N, Zheng TZ, Dai M, Zhang YW, Bassing BA, Wang QY Tags: Biomed Environ Sci Source Type: research

Subacute effect of decabromodiphenyl ethane on hepatotoxicity and hepatic enzyme activity in rats.
Abstract This paper is aimed to study the effect of ADL on expression of β1-AR and M2-AchR in myocardial cells of rats exposed to microwave radiation. Immunohistochemistry, Western blot and image analysis were used to detect the expression of β1-AR and M2-AchR in myocardial cells at 7 and 14 d after microwave exposure. The results show that the expression level was higher in microwave exposure group and 0.75 g/(kg•d) ADL group than in sham operation group and significantly lower in 1.5 and 3.0 g/(kg•d) ADL groups than in microwave group. So we have a conclusion that the expression of β1-AR and M2-AchR is dow...
Source: Biomedical and Environmental Sciences : BES - March 1, 2014 Category: Biomedical Science Authors: Zhang J, Peng RY, Gao YB, Wang SM, Yang LL, Zhao L, Dong J, Yao BW, Chang GM, Xiong L Tags: Biomed Environ Sci Source Type: research

Sodium Butyrate Induces Apoptosis of Human Colon Cancer Cells by Modulating ERK and Sphingosine Kinase 2.
CONCLUSION: ERK regulates the export of SphK2 and apoptosis of HCT116 cells by modulating PKD. Modulation of these molecules may help increase the sensitivity of colon cancer cells to the physiologic anti-colon cancer agent, NaBT. PMID: 24709100 [PubMed - in process] (Source: Biomedical and Environmental Sciences : BES)
Source: Biomedical and Environmental Sciences : BES - March 1, 2014 Category: Biomedical Science Authors: Xiao M, Liu YG, Zou MC, Zou F Tags: Biomed Environ Sci Source Type: research

Cyanidin-3-O-galactoside and Blueberry Extracts Supplementation Improves Spatial Memory and Regulates Hippocampal ERK Expression in Senescence-accelerated Mice.
CONCLUSION: Blueberry extracts may reverse the declines of cognitive and behavioral function in the ageing process through several pathways, including enhancing the capacity of antioxidation, altering stress signaling. Cy-3-GAL may be an important active ingredient for these biological effects. PMID: 24709099 [PubMed - in process] (Source: Biomedical and Environmental Sciences : BES)
Source: Biomedical and Environmental Sciences : BES - March 1, 2014 Category: Biomedical Science Authors: Tan L, Yang HP, Pang W, Lu H, Hu YD, Li J, Lu SJ, Zhang WQ, Jiang YG Tags: Biomed Environ Sci Source Type: research

The Impact of Lipid-metabolizing Genetic Polymorphisms on Body Mass Index and Their Interactions with Soybean Food Intake: A Study in a Chinese Population.
CONCLUSION: Our study has suggested that rs3846662 and rs3846663 may be the potential candidate polymorphisms for obesity, and their effect on the pathogenesis could be mediated by the frequency of soybean food intake. PMID: 24709098 [PubMed - in process] (Source: Biomedical and Environmental Sciences : BES)
Source: Biomedical and Environmental Sciences : BES - March 1, 2014 Category: Biomedical Science Authors: Wang JW, Tang X, Li N, Wu YQ, Li S, Li J, Qin XY, Zhang ZX, Hu YH, Chen da F Tags: Biomed Environ Sci Source Type: research