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Biomedical Science

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 9.

Factors influencing the number of rabies cases in children in china.
In conclusion, the prevalence of rabies cases in children in China remains a serious concern, the number and immune status of dogs in rural areas, and knowledge of rabies by risk populations should be considered in future rabies prevention and control programs. PMID: 25189609 [PubMed - in process] (Source: Biomedical and Environmental Sciences : BES)
Source: Biomedical and Environmental Sciences : BES - August 1, 2014 Category: Biomedical Science Authors: Song M, Tang Q, Rayner S, Tao XY, Shen XX, Liang GD Tags: Biomed Environ Sci Source Type: research

Secular changes of stature in rural children and adolescents in china, 1985-2010.
CONCLUSION: Positive secular trend in stature of children or adolescents has occurred in rural area of China, and rural boys and girls showed a great potential for continuous growth. More attention should be paid to the differences in children's body height between western region and eastern/central region. PMID: 25189603 [PubMed - in process] (Source: Biomedical and Environmental Sciences : BES)
Source: Biomedical and Environmental Sciences : BES - August 1, 2014 Category: Biomedical Science Authors: Chen TJ, Ji CY Tags: Biomed Environ Sci Source Type: research

An Objective Measure to Evaluate Actual Body Shape among Children and Adolescents in China.
CONCLUSION: The objective measure which included four dimensions was explored, and TD, TLD, and WD had significant discrimination power. PMID: 25189604 [PubMed - in process] (Source: Biomedical and Environmental Sciences : BES)
Source: Biomedical and Environmental Sciences : BES - August 1, 2014 Category: Biomedical Science Authors: Fu LG, Wang HJ, Li XH, Wang ZQ, Lau PW, Yang YD, Meng XK, Ma J Tags: Biomed Environ Sci Source Type: research

Serum Calcium Level is Associated with Brachial-ankle Pulse Wave Velocity in Middle-aged and Elderly Chinese.
CONCLUSION: The elevated serum calcium level is related to an elevated BaPWV and a higher risk of arterial stiffness, independent of conventional risk factors, in middle-aged and elderly Chinese subjects. PMID: 25189605 [PubMed - in process] (Source: Biomedical and Environmental Sciences : BES)
Source: Biomedical and Environmental Sciences : BES - August 1, 2014 Category: Biomedical Science Authors: Deng XR, Zhang YF, Wang TG, Xu BH, Sun JC, Zhao LB, Xu M, Chen YH, Wang WQ, Bi YF, Lu JL Tags: Biomed Environ Sci Source Type: research

Elevated Resting Heart Rate is Associated with Dyslipidemia in Middle-aged and Elderly Chinese.
CONCLUSION: Elevated resting heart rate is associated with high TG and TC in middle-aged and elderly Chinese subjects. PMID: 25189606 [PubMed - in process] (Source: Biomedical and Environmental Sciences : BES)
Source: Biomedical and Environmental Sciences : BES - August 1, 2014 Category: Biomedical Science Authors: Sun JC, Huang XL, Deng XR, Lv XF, Lu JL, Chen YH, Bi YF, Wang WQ, Xu M, Ning G Tags: Biomed Environ Sci Source Type: research

Protein Requirements in Healthy Adults: A Meta-analysis of Nitrogen Balance Studies.
CONCLUSION: The estimated average requirement and recommended nutrient intake of the healthy adult population was 105.64 mg N/kg•d (0.66 g high quality protein/kg•d) and 132.05 mg N/kg•d (0.83 g high quality protein/kg•d), respectively. PMID: 25189607 [PubMed - in process] (Source: Biomedical and Environmental Sciences : BES)
Source: Biomedical and Environmental Sciences : BES - August 1, 2014 Category: Biomedical Science Authors: Li M, Sun F, Piao JH, Yang XG Tags: Biomed Environ Sci Source Type: research

An evaluation of genotoxicity and cytotoxicity of melamine in combination with cyanuric Acid at three mass ratios.
The objective of this study was designed to evaluate the combined genotoxicity and cytotoxicity of melamine (M) and cyanuric acid (C) at three mass ratios (1:1, 1:2, 2:1). MC (1:1), MC (1:2), and MC (2:1) were evaluated for their potential genotoxic risk, at gene level by Ames test, and at chromosomal level by micronucleus test. In order to evaluate cytotoxicity in HEK-293 cells, the MTT assay was included. Western blot was also employed to investigate the renal injury molecule-1 (Kim-1) expression in HEK-293 cells exposed to MC. Neither genotoxicity at gene level nor at chromosomal level was observed for MC (1:1), MC (1:2...
Source: Biomedical and Environmental Sciences : BES - August 1, 2014 Category: Biomedical Science Authors: Liu X, Huang da W, Wu KJ, Wu YN, Jia XW, Gong ZY Tags: Biomed Environ Sci Source Type: research

Malnutrition prevalence in lasa xizang children and adolescents.
CONCLUSION: Stunting and wasting rates of Tibetan children and adolescents indicate a gradual declining trend over time. The stunting rates of both boys and girls during early puberty were significantly higher than those during late puberty. PMID: 25189608 [PubMed - in process] (Source: Biomedical and Environmental Sciences : BES)
Source: Biomedical and Environmental Sciences : BES - August 1, 2014 Category: Biomedical Science Authors: Yin XJ, Ji CY Tags: Biomed Environ Sci Source Type: research

Association of bisphenol a exposure with circulating sex hormone concentrations in men and postmenopausal women.
Abstract A total of 1116 middle-aged and elderly men and 1442 postmenopausal women were recruited in this study. Whether bisphenol A exposure was associated with circulating sex hormone concentrations was studied. Univariate analysis revealed that the urinary bisphenol A concentration was negatively correlated with the serum levels of luteinizing hormone (β=-0.061, P<0.0001) and follicle-stimulating hormone (β=-0.086, P<0.0001) in men, and with the serum levels of follicle-stimulating hormone (β=-0.037, P=0.018) and sex hormone-binding globulin (β=-0.043, P=0.006) in women. However, no significant associa...
Source: Biomedical and Environmental Sciences : BES - August 1, 2014 Category: Biomedical Science Authors: Li M, Wang TG, Xu Y, Zhang J, Xu BH, Xu M, Chen YH, Lu JL, Bi YF, Wang WQ, Gu YY, Ning G Tags: Biomed Environ Sci Source Type: research

Understanding the Supports of and Challenges to Community Engagement in the CTSAs
ConclusionThe CTSAs have brought much‐needed attention to community engagement in research, but more can be done to adequately support engagement. Challenges remain that need to be addressed to achieve the potential benefits of engagement. Clin Trans Sci 2014; Volume #: 1–7 (Source: Clinical and Translational Science)
Source: Clinical and Translational Science - August 1, 2014 Category: Biomedical Science Authors: Jessica Holzer, Nancy Kass Tags: Article Source Type: research

Bacterial communities associated with an occurrence of colored water in an urban drinking water distribution system.
This study aimed to investigate bacterial community in an urban drinking water distribution system (DWDS) during an occurrence of colored water. Variation in the bacterial community diversity and structure was observed among the different waters, with the predominance of Proteobacteria. While Verrucomicrobia was also a major phylum group in colored water. Limnobacter was the major genus group in colored water, but Undibacterium predominated in normal tap water. The coexistence of Limnobacter as well as Sediminibacterium and Aquabacterium might contribute to the formation of colored water. PMID: 25189613 [PubMed - in p...
Source: Biomedical and Environmental Sciences : BES - August 1, 2014 Category: Biomedical Science Authors: Wu HT, Mi ZL, Zhang JX, Chen C, Xie SG Tags: Biomed Environ Sci Source Type: research

Influence of soy isoflavone on lindane cumulant in sprague-dawley rats.
This study indicated that soy isoflavones could reduce the level of lindane in rat's body. Lindane could reduce the level of hormones and decreased the effect of soy isoflavones on rat's uterus. PMID: 25189611 [PubMed - in process] (Source: Biomedical and Environmental Sciences : BES)
Source: Biomedical and Environmental Sciences : BES - August 1, 2014 Category: Biomedical Science Authors: Yang Y, Zhang YB, Sheng W, Fu ZH, Wang Z, Wang X, Guan SY, Na XL Tags: Biomed Environ Sci Source Type: research

Editorial.
PMID: 25081502 [PubMed - as supplied by publisher] (Source: Acta Biotheoretica)
Source: Acta Biotheoretica - August 1, 2014 Category: Biomedical Science Authors: Seck D, Balde M, Bah A Tags: Acta Biotheor Source Type: research

Automatic analyzer for highly polar carboxylic acids based on fluorescence derivatization-liquid chromatography.
Abstract A sensitive, versatile, and reproducible automatic analyzer for highly polar carboxylic acids based on a fluorescence derivatization-liquid chromatography (LC) method was developed. In this method, carboxylic acids were automatically and fluorescently derivatized with 4-(N,N-dimethylaminosulfonyl)-7-piperazino-2,1,3-benzoxadiazole (DBD-PZ) in the presence of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride by adopting a pretreatment program installed in an LC autosampler. All of the DBD-PZ-carboxylic acid derivatives were separated on the ODS column within 30 min by gradient elution. Th...
Source: Biomedical Chromatography : BMC - August 1, 2014 Category: Biomedical Science Authors: Todoroki K, Nakano T, Ishii Y, Goto K, Tomita R, Fujioka T, Min JZ, Inoue K, Toyo'oka T Tags: Biomed Chromatogr Source Type: research

Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking.
Abstract In lymphocytes, the kinase Mst1 is required for the proper organization of integrins in the plasma membrane at the leading edge of migrating cells, which is critical for lymphocyte trafficking. We found a functional link between the small G protein Rab13 and Mst1 in lymphocyte adhesion and migration. In response to stimulation of T lymphocytes with chemokine, Mst1 promoted phosphorylation of the guanine nucleotide exchange factor DENND1C (differentially expressed in normal and neoplastic cells domain 1C), which activated Rab13. Active Rab13 associated with Mst1 to facilitate the delivery of the integrin LF...
Source: Science Signaling - July 31, 2014 Category: Biomedical Science Authors: Nishikimi A, Ishihara S, Ozawa M, Etoh K, Fukuda M, Kinashi T, Katagiri K Tags: Sci Signal Source Type: research

The COP II adaptor protein TMED7 is required to initiate and mediate the delivery of TLR4 to the plasma membrane.
Abstract Toll-like receptor 4 (TLR4), the receptor for the bacterial product endotoxin, is subject to multiple points of regulation at the levels of signaling, biogenesis, and trafficking. Dysregulation of TLR4 signaling can cause serious inflammatory diseases, such as sepsis. We found that the p24 family protein TMED7 (transmembrane emp24 protein transport domain containing 7) is required for the trafficking of TLR4 from the endoplasmic reticulum to the cell surface through the Golgi. TMED7 formed a stable complex with the ectodomain of TLR4, an interaction that required the coiled-coil and Golgi dynamics (GOLD) d...
Source: Science Signaling - July 31, 2014 Category: Biomedical Science Authors: Liaunardy-Jopeace A, Bryant CE, Gay NJ Tags: Sci Signal Source Type: research

MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer.
Abstract Sirtuin 6 (SIRT6) is associated with longevity and is also a tumor suppressor. Identification of molecular regulators of SIRT6 might enable its activation therapeutically in cancer patients. In various breast cancer cell lines, we found that SIRT6 was phosphorylated at Ser(338) by the kinase AKT1, which induced the interaction and ubiquitination of SIRT6 by MDM2, targeting SIRT6 for protease-dependent degradation. The survival of breast cancer patients positively correlated with the abundance of SIRT6 and inversely correlated with the phosphorylation of SIRT6 at Ser(338). In a panel of breast tumor biopsie...
Source: Science Signaling - July 31, 2014 Category: Biomedical Science Authors: Thirumurthi U, Shen J, Xia W, LaBaff AM, Wei Y, Li CW, Chang WC, Chen CH, Lin HK, Yu D, Hung MC Tags: Sci Signal Source Type: research

Small RNAs in blood may reveal heart injury
(Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - July 31, 2014 Category: Biomedical Science Authors: pubaff Tags: Science News heart injury Kemal Akat MicroRNAs Thomas Tuschl Source Type: news

A comparison of optimization methods and knee joint degrees of freedom on muscle force predictions during single-leg Hop landings
The aim of this paper was to compare the effect of different optimization methods and different knee joint degrees of freedom (DOF) on muscle force predictions during a single legged hop. Nineteen subjects performed single-legged hopping manoeuvres and subject-specific musculoskeletal models were developed to predict muscle forces during the movement. Muscle forces were predicted using static optimization (SO) and computed muscle control (CMC) methods using either 1 or 3 DOF knee joint models. All sagittal and transverse plane joint angles calculated using inverse kinematics or CMC in a 1 DOF or 3 DOF knee were well-matche...
Source: Journal of Biomechanics - July 31, 2014 Category: Biomedical Science Authors: Hossein Mokhtarzadeh, Luke Perraton, Laurence Fok, Mario A. Muñoz, Ross Clark, Peter Pivonka, Adam Leigh Bryant Source Type: research

Analysis of nuclear RNA interference in human cells by subcellular fractionation and Argonaute loading
Nature Protocols 9, 2045 (2014). doi:10.1038/nprot.2014.135 Authors: Keith T Gagnon, Liande Li, Bethany A Janowski & David R Corey RNAi is well known for its ability to regulate gene expression in the cytoplasm of mammalian cells. In mammalian cell nuclei, however, the impact of RNAi has remained more controversial. A key technical hurdle has been a lack of optimized protocols for the isolation and (Source: Nature Protocols)
Source: Nature Protocols - July 31, 2014 Category: Biomedical Science Authors: Keith T GagnonLiande LiBethany A JanowskiDavid R Corey Tags: Protocol Source Type: research

Mathematical Analysis of a Chlamydia Epidemic Model with Pulse Vaccination Strategy.
Abstract In this paper, we have considered a dynamical model of Chlamydia disease with varying total population size, bilinear incidence rate and pulse vaccination strategy. We have defined two positive numbers [Formula: see text] and [Formula: see text]. It is proved that there exists an infection-free periodic solution which is globally attractive if [Formula: see text] and the disease is permanent if [Formula: see text] The important mathematical findings for the dynamical behaviour of the Chlamydia disease model are also numerically verified using MATLAB. Finally epidemiological implications of our analytical f...
Source: Acta Biotheoretica - July 31, 2014 Category: Biomedical Science Authors: Samanta GP Tags: Acta Biotheor Source Type: research

In-cell 13C NMR spectroscopy for the study of intrinsically disordered proteins
Nature Protocols 9, 2005 (2014). doi:10.1038/nprot.2014.124 Authors: Isabella C Felli, Leonardo Gonnelli & Roberta Pierattelli A large number of proteins carry out their function in highly flexible and disordered states, lacking a well-defined 3D structure. These proteins, referred to as intrinsically disordered proteins (IDPs), are now in the spotlight of modern structural biology. Nuclear magnetic resonance (NMR) spectroscopy represents a (Source: Nature Protocols)
Source: Nature Protocols - July 31, 2014 Category: Biomedical Science Authors: Isabella C FelliLeonardo GonnelliRoberta Pierattelli Tags: Protocol Source Type: research

Optimization of nucleophilic 18F radiofluorinations using a microfluidic reaction approach
Nature Protocols 9, 2017 (2014). doi:10.1038/nprot.2014.137 Authors: Giancarlo Pascali, Lidia Matesic, Thomas L Collier, Naomi Wyatt, Benjamin H Fraser, Tien Q Pham, Piero A Salvadori & Ivan Greguric Microfluidic techniques are increasingly being used to synthesize positron-emitting radiopharmaceuticals. Several reports demonstrate higher incorporation yields, with shorter reaction times and reduced amounts of reagents compared with traditional vessel-based techniques. Microfluidic techniques, therefore, have tremendous potential for allowing rapid and cost-effective optimization of new radiotracers. (Source: Nature Protocols)
Source: Nature Protocols - July 31, 2014 Category: Biomedical Science Authors: Giancarlo PascaliLidia MatesicThomas L CollierNaomi WyattBenjamin H FraserTien Q PhamPiero A SalvadoriIvan Greguric Tags: Protocol Source Type: research

Engineering the oxygen sensing regulation results in an enhanced recombinant human hemoglobin production by the model yeast Saccharomyces cerevisiae
In this study, we propose a strategy for further engineering S. cerevisiae by altering the oxygen sensing pathway by deleting the transcription factor HAP1, which resulted in an increase of the final recombinant active hemoglobin titer exceeding 7% of the total cellular protein. Biotechnol. Bioeng. © 2014 Wiley Periodicals, Inc. (Source: Biotechnology and Bioengineering)
Source: Biotechnology and Bioengineering - July 31, 2014 Category: Biomedical Science Authors: José L. Martínez, Lifang Liu, Dina Petranovic, Jens Nielsen Tags: Cellular and Metabolic Engineering Source Type: research

A Unique Noninvasive Approach to Monitoring Dissolved O2 and CO2 in Cell Culture
Abstract Although online monitoring of dissolved oxygen (DO) and carbon dioxide (DCO2) is highly desirable in bioprocesses, small‐scale bioreactors are usually not monitored due to the lack of suitable sensors. Traditional electrochemical sensors are usually not used because they are bulky and invasive. Disposable optical sensors are small and only partially invasive, but there are concerns regarding the toxicity of the patch and the phototoxicity of the illuminating light. Here we present a novel, noninvasive, rate‐based technique for monitoring DO and DCO2 in cell cultures. A silicone sampling loop which allowed the ...
Source: Biotechnology and Bioengineering - July 31, 2014 Category: Biomedical Science Authors: Madhubanti Chatterjee, Xudong Ge, Shaunak Uplekar, Yordan Kostov, Leah Croucher, Govind Rao Tags: Bioprocess Engineering and Supporting Technologies Source Type: research

Adaptation of Tri‐molecular Fluorescence Complementation allows assaying of regulatory Csr RNA‐protein interactions in bacteria
We describe the construction of a fluorescence complementation system that detects the interactions between CsrB and CsrA. Additionally, we demonstrate that the intensity of the fluorescence of this system is able to detect changes in the affinity of the CsrB‐CsrA interaction, as caused by mutations in the protein sequence of CsrA. While previous methods have adopted this technique to study mRNA or RNA localization, this is the first attempt to use this technique to study the sRNA‐protein interaction directly in bacteria. This method presents a potentially powerful tool to study complex bacterial RNA protein interactio...
Source: Biotechnology and Bioengineering - July 31, 2014 Category: Biomedical Science Authors: Grant Gelderman, Anusha Sivakumar, Sarah Lipp, Lydia Contreras Tags: Engineering Science of Biological Systems Source Type: research

A comparison of optimisation methods and knee joint degrees of freedom on muscle force predictions during single-leg hop landings
The aim of this paper was to compare the effect of different optimisation methods and different knee joint degrees of freedom (DOF) on muscle force predictions during a single legged hop. Nineteen subjects performed single-legged hopping manoeuvres and subject-specific musculoskeletal models were developed to predict muscle forces during the movement. Muscle forces were predicted using static optimisation (SO) and computed muscle control (CMC) methods using either 1 or 3 DOF knee joint models. All sagittal and transverse plane joint angles calculated using inverse kinematics or CMC in a 1 DOF or 3 DOF knee were well-matche...
Source: Journal of Biomechanics - July 31, 2014 Category: Biomedical Science Authors: Hossein Mokhtarzadeh, Luke Perraton, Laurence Fok, Mario A. Muñoz, Ross Clark, Peter Pivonka, Adam L. Bryant Source Type: research

Does registration of the medical science workforce deliver a competent profession?
PMID: 25087977 [PubMed - as supplied by publisher] (Source: Clinical Biochemistry)
Source: Clinical Biochemistry - July 31, 2014 Category: Biochemistry Authors: Badrick T, StJohn A Tags: Clin Biochem Source Type: research

Quantitative profiling of the protein coronas that form around nanoparticles
Nature Protocols 9, 2030 (2014). doi:10.1038/nprot.2014.139 Authors: Dominic Docter, Ute Distler, Wiebke Storck, Jörg Kuharev, Desirée Wünsch, Angelina Hahlbrock, Shirley K Knauer, Stefan Tenzer & Roland H Stauber Nanoparticle applications in biotechnology and biomedicine are steadily increasing. In biological fluids, proteins bind to nanoparticles that form the protein corona, crucially affecting the nanoparticles' biological identity. As the corona affects in vitro and/or in vivo nanoparticle applications, we developed a method to (Source: Nature Protocols)
Source: Nature Protocols - July 31, 2014 Category: Biomedical Science Authors: Dominic DocterUte DistlerWiebke StorckJörg KuharevDesirée WünschAngelina HahlbrockShirley K KnauerStefan TenzerRoland H Stauber Tags: Protocol Source Type: research

Effect of liquid hot water pretreatment severity on properties of hardwood lignin and enzymatic hydrolysis of cellulose
Abstract Lignin, one of the major components of lignocellulosic biomass, plays an inhibitory role on the enzymatic hydrolysis of cellulose. This work examines the role of lignin in pretreated hardwood, where extents of cellulose hydrolysis decrease, rather than increase with increasing severity of liquid hot water pretreatment. Hardwood pretreated with liquid hot water at severities ranging from log Ro = 8.25 to 12.51 resulted in 80 to 90% recovery of the initial lignin in the residual solids. The ratio of acid insoluble lignin (AIL) to acid soluble lignin (ASL) increased and the formation of spherical lignin droplets on t...
Source: Biotechnology and Bioengineering - July 31, 2014 Category: Biomedical Science Authors: Ja Kyong Ko, Youngmi Kim, Eduardo Ximenes, Michael R. Ladisch Tags: Biofuels and Environmental Biotechnology Source Type: research

Association of Learning Styles with Research Self‐Efficacy: Study of Short‐Term Research Training Program for Medical Students
ConclusionsAssessments of learning styles may provide useful information to guide future training endeavors aimed at developing the next generation of physician‐scientists. Clin Trans Sci 2014; Volume #: 1–4 (Source: Clinical and Translational Science)
Source: Clinical and Translational Science - July 31, 2014 Category: Biomedical Science Authors: Jill Dumbauld, Michelle Black, Colin A. Depp, Rebecca Daly, Maureen A. Curran, Babbi Winegarden, Dilip V. Jeste Tags: Communication Source Type: research

Non‐destructive Label‐free Continuous Monitoring of In Vitro Chondrogenesis via Electrical Conductivity and Its Anisotropy
Abstract Non‐destructive label‐free continuous monitoring of in vitro tissue culture is an unmet demand in tissue engineering. Noting that different compositions of cartilage lead to different electrical tissue properties, we propose a new method to measure the electrical conductivity and its anisotropy during in vitro chondrogenesis. We used aconductivity tensor probe with 17 electrodes and a bio‐impedance spectroscopy (BIS) device to measure the conductivity values and the anisotropy ratios at the bottom and top surfaces of the tissue samples during the culture period of six weeks. Clearly distinguishing glycosamin...
Source: Biotechnology and Bioengineering - July 31, 2014 Category: Biomedical Science Authors: Tong In Oh, Changhwan Kim, Bishal Karki, Youngsook Son, EunAh Lee, Eung Je Woo Tags: Tissue Engineering and Delivery Systems Source Type: research

Morphology engineering for improving fungal lipid accumulation
(Source: Biotechnology and Bioengineering)
Source: Biotechnology and Bioengineering - July 30, 2014 Category: Biomedical Science Tags: Spotlight Source Type: research

Cancer = (Mutation × Selection)n
(Source: Biotechnology and Bioengineering)
Source: Biotechnology and Bioengineering - July 30, 2014 Category: Biomedical Science Tags: Spotlight Source Type: research

Cell signaling as factor in biomaterials development
(Source: Biotechnology and Bioengineering)
Source: Biotechnology and Bioengineering - July 30, 2014 Category: Biomedical Science Tags: Spotlight Source Type: research

Segmented flow biofilm microreactor: Engineering biofilm growth for catalysis
(Source: Biotechnology and Bioengineering)
Source: Biotechnology and Bioengineering - July 30, 2014 Category: Biomedical Science Tags: Spotlight Source Type: research

CXCR4 dysfunction in non-alcoholic steatohepatitis in mice and patients
In conclusion, the CXCL12/CXCR4 pathway contributes in both mice and patients to the enhanced recruitment of CD4+ T in NASH. An increased affinity of CXCL12 to CXCR4 rather than a higher expression of the chemokine or its receptors is involved in this process. (Source: Clinical Science)
Source: Clinical Science - July 30, 2014 Category: Biomedical Science Authors: H Boujedidi, O Robert, A Bignon, A Cassard-Doulcier, M Renoud, H Gary-Gouy, P Hemon, H Tharinger, S Prévot, F Bachelerie, S Naveau, D Emilie, K Balabanian, G Perlemuter Source Type: research

Biotechnology and Bioengineering: Volume 111, Number 9, September 2014
Cover Legend Image of micro bubble rising in the microbubble column reactor. (Image courtesy of Dr. Rainer Krull et al.) (Source: Biotechnology and Bioengineering)
Source: Biotechnology and Bioengineering - July 30, 2014 Category: Biomedical Science Tags: Cover Source Type: research

Biotechnology and Bioengineering: Volume 111, Number 9, September 2014
(Source: Biotechnology and Bioengineering)
Source: Biotechnology and Bioengineering - July 30, 2014 Category: Biomedical Science Tags: Contents Source Type: research

Test–retest reliability for assessment of postural stability using center of pressure spatial patterns of three-dimensional statokinesigrams in young health participants
This study investigated the test–retest reliability for assessment of postural stability using a quantitative method for identification of center of pressure (CoP) spatial patterns of three-dimensional statokinesigrams (3D-SKG). (Source: Journal of Biomechanics)
Source: Journal of Biomechanics - July 30, 2014 Category: Biomedical Science Authors: Arthur de Sá Ferreira, Patrícia Junqueira Ferraz Baracat Source Type: research

Investigation of impact loading rate Effects on the ligamentous cervical spinal load-Partitioning using finite element model of functional spinal unit C2-C3
The cervical spine functions as a complex mechanism that responds to sudden loading in a unique manner, due to intricate structural features and kinematics. The spinal load-sharing under pure compression and sagittal flexion/extension at two different impact rates were compared using a bio-fidelic Finite Element (FE) model of the ligamentous cervical Functional Spinal Unit (FSU) C2-C3. This model was developed using a comprehensive and realistic geometry of spinal components and material laws that include strain rate dependency, bone fracture, and ligament failure. (Source: Journal of Biomechanics)
Source: Journal of Biomechanics - July 30, 2014 Category: Biomedical Science Authors: Tanvir Mustafy, Marwan El-Rich, Wissal Mesfar, Kodjo Moglo Source Type: research

Test-retest reliability for assessment of postural stability using center of pressure spatial patterns of three-dimensional statokinesigrams in young health participants
This study investigated the test-retest reliability for assessment of postural stability using a quantitative method for identification of center of pressure (CoP) spatial patterns of three-dimensional statokinesigrams (3D-SKG). (Source: Journal of Biomechanics)
Source: Journal of Biomechanics - July 30, 2014 Category: Biomedical Science Authors: Arthur de Sá Ferreira, Patrícia Junqueira Ferraz Baracat Source Type: research

Lower-limb amputee recovery response to an imposed error in mediolateral foot placement
Despite walking with a wider step width, amputees remain 20% more likely to fall than non-amputees. Since mediolateral (ML) balance is critical for ambulation and contingent on ML foot placement, we used a ML disturbance to perturb walking balance and explore the influence of prosthetic foot stiffness on balance recovery. Ten transtibial amputees were fit with two commonly prescribed prosthetic feet with differing stiffness characteristics; twelve non-amputees also participated. A perturbation device that released an air burst just before heel strike imposed a repeatable medial or lateral disturbance in foot placement. (So...
Source: Journal of Biomechanics - July 30, 2014 Category: Biomedical Science Authors: Ava D. Segal, Glenn K. Klute Source Type: research

Can hyper-synchrony in meditation lead to seizures? Similarities in meditative and epileptic brain states
Meditation is used worldwide by millions of people for relaxation and stress relief. Given sufficient practice, meditators may also experience a variety of altered states of consciousness. These states can lead to a variety of unusual experiences, including physical, emotional and psychic disturbances. This paper highlights the correspondences between brain states associated with these experiences and the symptoms and neurophysiology of epileptic simple partial seizures. Seizures, like meditation practice, can result in both positive and negative experiences. (Source: Medical Hypotheses)
Source: Medical Hypotheses - July 30, 2014 Category: Biomedical Science Authors: Shane Lindsay Source Type: research

Fluorescent TEM-1 β-Lactamase with Wild-Type Activity as a Rapid Drug Sensor for In Vitro Drug Screening.
We report the development of a novel fluorescent drug sensor from the bacterial drug target TEM-1 β-lactamase through the combined strategy of Val216→Cys216 mutation and fluorophore labelling for in vitro drug screening. The Val216 residue in TEM-1 is replaced with a cysteine residue, and the environment-sensitive fluorophore fluorescein-5-maleimide is specifically attached to the Cys216 residue in the V216C mutant for sensing drug binding at the active site. The labelled V216C mutant has wild-type catalytic activity and gives stronger fluorescence when β-lactam antibiotics bind to the active site. The labelled V216C m...
Source: Bioscience Reports - July 30, 2014 Category: Biomedical Science Authors: Cheong WL, Tsang MS, So PK, Chung WH, Leung YC, Chan PH Tags: Biosci Rep Source Type: research

Medical innovation requires federal support and structural improvements, Marc Tessier-Lavigne tells members of Congress
Speaking at a hearing on public versus private contributions to medical breakthroughs, Rockefeller's president explained the ecosystem responsible for taking a biological insight on, for example, how tumors spread, and turning it into a treatment that improves or saves lives. He also offered suggestions for how the federal government could further encourage such breakthroughs. More » (Source: The Rockefeller University Newswire)
Source: The Rockefeller University Newswire - July 29, 2014 Category: Biomedical Science Authors: pubaff Tags: Public Affairs Source Type: news

The Research Launchpad: Measuring the Efficiency and Effectiveness of CTSA Resource and Service Provision
(Source: Clinical and Translational Science)
Source: Clinical and Translational Science - July 29, 2014 Category: Biomedical Science Authors: Arianne E. Rhea, Wei Xu, Jingyuan Gu Tags: Profile: CTSA Source Type: research

Heterogeneity in cord blood DHA concentration: Towards an explanation
This paper aimed to identify the dietary and non-dietary determinants of docosahexaenoic acid (DHA) levels in umbilical cord blood at delivery. DHA was measured in cord blood plasma phospholipids of 1571 participants from the DOMInO (DHA to Optimize Mother Infant Outcome) randomized controlled trial. Socioeconomic, lifestyle and clinical data relating to the mother and current pregnancy were obtained from all women and their relationships with cord blood DHA assessed. DHA concentrations in the cord plasma phospholipids at delivery covered a 3–4 fold range in both control and DHA groups. (Source: Prostaglandins, Leukotrie...
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - July 29, 2014 Category: Biomedical Science Authors: B.S. Muhlhausler, R.A. Gibson, L.N. Yelland, M. Makrides Source Type: research

Effects of chronic administration of arachidonic acid on lipid profiles and morphology in the skeletal muscles of aged rats
In this study, we examined the effects of chronic administration (13 weeks) of ARA (240mg/kg/day) on fatty acid composition, antioxidative status, and morphology of slow (soleus muscles) and fast (extensor digitorum longus muscles; EDL)-twitch muscles in aged rats (21 months old). (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - July 29, 2014 Category: Biomedical Science Authors: Takayuki Inoue, Michio Hashimoto, Masanori Katakura, Yoko Tanabe, Abdullah Al Mamun, Kentaro Matsuzaki, Hiroki Otani, Osamu Shido Source Type: research

Effects of chronic administration of arachidonic acid on lipid profiles and morphology in the skeletal muscles of aged rats
In this study, we examined the effects of chronic administration (13 weeks) of ARA (240mg/kg/day) on fatty acid composition, antioxidative status, and morphology of slow (soleus muscles) and fast (extensor digitorum longus muscles; EDL)-twitch muscles in aged rats (21 months old). (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - July 29, 2014 Category: Biomedical Science Authors: Takayuki Inoue, Michio Hashimoto, Masanori Katakura, Yoko Tanabe, Abdullah Al Mamun, Kentaro Matsuzaki, Hiroki Otani, Osamu Shido Source Type: research