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This page shows you the 20 most read items in the past 30 days within this specialty in the MedWorm directory.

Modeling the influence of cyclodextrins on oral absorption of low solubility drugs: II. Experimental validationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A model was developed for predicting the influence of cyclodextrins (CDs) delivered as a physical mixture with drug on oral absorption. CDs are cyclic oligosaccharides which form inclusion complexes with many drugs and are often used as solubilizing agents. The purpose of this work is to compare the simulation predictions with in vitro as well as in vivo experimental results to test the model's ability to capture the influence of CD on key processes in the gastrointestinal (GI) tract environment. Dissolution and absorption kinetics of low solubility drugs (Naproxen and Nifedipine) were tested in the presence and absence of...
Source: Biotechnology and Bioengineering - November 1, 2009 Category: Biomedical Science Authors: Ece Dilber Gamsiz, Lee Miller, Avinash G. Thombre, Imran Ahmed, Rebecca Lyn Carrier Source Type: journals

Green LightEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Using a molecule that makes creatures glow green, Marc Zimmer shows his students that chemistry can be cool. He also enlists his family pets—mice and fish that can turn a rainbow of colors. Read more. (Source: NIGMS Findings)
Source: NIGMS Findings - November 5, 2009 Category: Biomedical Science Source Type: consumer

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 13, 2009 Category: Biomedical Science Tags: Frontmatter Source Type: journals

ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 13, 2009 Category: Biomedical Science Tags: Frontmatter Source Type: journals

In This IssueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Clinical Investigation)
Source: Journal of Clinical Investigation - November 3, 2009 Category: Biomedical Science Source Type: journals

Herbal Medicine May Counter Pain Killer's Liver ToxicityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A well-known Eastern herbal supplement may help avoid the most common cause of liver transplantation, according to an NIGMS-supported study. (Source: NIGMS - Results)
Source: NIGMS - Results - November 19, 2009 Category: Biomedical Science Source Type: news

Notes to ContributorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Metabolism - Clinical and Experimental)
Source: Metabolism - Clinical and Experimental - November 13, 2009 Category: Biomedical Science Tags: Frontmatter Source Type: journals

Life at the Duke of SingaporeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Clinical Investigation)
Source: Journal of Clinical Investigation - November 3, 2009 Category: Biomedical Science Authors: Karen Honey Source Type: journals

Identification of FGFR4-activating mutations in human rhabdomyosarcomas that promote metastasis in xenotransplanted modelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Rhabdomyosarcoma (RMS) is a childhood cancer originating from skeletal muscle, and patient survival is poor in the presence of metastatic disease. Few determinants that regulate metastasis development have been identified. The receptor tyrosine kinase FGFR4 is highly expressed in RMS tissue, suggesting a role in tumorigenesis, although its functional importance has not been defined. Here, we report the identification of mutations in FGFR4 in human RMS tumors that lead to its activation and present evidence that it functions as an oncogene in RMS. Higher FGFR4 expression in RMS tumors was associated with advanced-stage canc...
Source: Journal of Clinical Investigation - November 3, 2009 Category: Biomedical Science Authors: James G. Taylor VI, Adam T. Cheuk, Patricia S. Tsang, Joon-Yong Chung, Young K. Song, Krupa Desai, Yanlin Yu, Qing-Rong Chen, Kushal Shah, Victoria Youngblood, Jun Fang, Su Young Kim, Choh Yeung, Lee J. Helman, Arnulfo Mendoza, Vu Ngo, Louis M. Staudt, Ju Source Type: journals

Researchers Image Crucial Anthrax ProteinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
NIGMS-supported researchers have determined the structure of a protein crucial to the virulence of anthrax bacteria. (Source: NIGMS - Results)
Source: NIGMS - Results - July 14, 2009 Category: Biomedical Science Source Type: news

Enzyme Could be Key to Treating TuberculosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
NIGMS-funded researchers have identified an enzyme that helps tuberculosis bacteria resist humans' natural defense system. (Source: NIGMS - Results)
Source: NIGMS - Results - October 2, 2009 Category: Biomedical Science Source Type: news

Gene-expression-based quality scores indicate optimal harvest point in Bordetella pertussis cultivation for vaccine productionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The evolution of vaccine product quality during batch cultivation of Bordetella pertussis, the causative agent of whooping cough, was investigated with the goal to determine the optimal harvest point. The process was explored by measuring mRNA expression at frequent intervals during cultivation. The genes that are involved in virulence are already known for this product and changes in their expression levels are proposed to be indicative for product quality. A quantitative product quality score is calculated based on the expression levels of these virulence genes, which allows comparison of expected product quality between...
Source: Biotechnology and Bioengineering - March 25, 2009 Category: Biomedical Science Authors: Bas van de Waterbeemd, Mathieu Streefland, Jeroen Pennings, Leo van der Pol, Coen Beuvery, Johannes Tramper, Dirk Martens Source Type: journals

A practical approach for exploration and modeling of the design space of a bacterial vaccine cultivation processEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article demonstrates how the general principles of PAT and process design space can be applied for an undefined biological product such as a whole cell vaccine. The approach chosen for model development described here, allows on line monitoring and control of cultivation batches in order to assure in real time that a process is running within the process design space. Biotechnol. Bioeng. © 2009 Wiley Periodicals, Inc. (Source: Biotechnology and Bioengineering)
Source: Biotechnology and Bioengineering - July 12, 2009 Category: Biomedical Science Authors: M. Streefland, P.F.G. Van Herpen, B. Van de Waterbeemd, L.A. Van der Pol, E.C. Beuvery, J. Tramper, D.E. Martens, M. Toft Source Type: journals

Seams in HIV Coat Could Lead to New DrugsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
NIGMS-supported structural biologists have identified functionally important ‘seams’ within the coat that surrounds the HIV genome. (Source: NIGMS - Results)
Source: NIGMS - Results - November 13, 2009 Category: Biomedical Science Source Type: news

Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we found that Smad4 was frequently downregulated not only in human head and neck squamous cell carcinoma (HNSCC) malignant lesions, but also in grossly normal adjacent buccal mucosa. To gain insight into the importance of this observation, we generated mice in which Smad4 was deleted in head and neck epithelia (referred to herein as HN-Smad4–/– mice) and found that they developed spontaneous HNSCC. Interestingly, both normal head and neck tissue and HNSCC from HN-Smad4–/– mice exhibited increased genomic instability, which correlated with downregulated expression and function ...
Source: Journal of Clinical Investigation - October 23, 2009 Category: Biomedical Science Authors: Sophia Bornstein, Ruth White, Stephen Malkoski, Masako Oka, Gangwen Han, Timothy Cleaver, Douglas Reh, Peter Andersen, Neil Gross, Susan Olson, Chuxia Deng, Shi-Long Lu, Xiao-Jing Wang Source Type: journals

Smad4: gatekeeper gene in head and neck squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Unchecked cell growth is a hallmark of cancer. During oncogenesis, cancerous cells become resistant to the TGF-β signaling pathway that usually keeps cell growth in check. The role of a critical mediator of this pathway, Smad4, in head and neck squamous cell carcinoma (HNSCC) remains unclear. In this issue of the JCI, Bornstein and colleagues report that Smad4 expression is decreased in malignant HNSCC and, surprisingly, also in normal-appearing buccal mucosa adjacent to HNSCC (see the related article, doi:10.1172/JCI38854). They also show that targeted conditional deletion of Smad4 in the head and neck epithelium ...
Source: Journal of Clinical Investigation - October 23, 2009 Category: Biomedical Science Authors: Murray Korc Source Type: journals

HIV vaccine failure probably caused by virus used, says new researchEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Immunity to adenovirus means some people had a higher risk of HIV infection in STEP Trial - News Release (Source: Imperial College News)
Source: Imperial College News - November 17, 2009 Category: Biomedical Science Source Type: organizations

Vaccinating 70 Percent Would Control Swine FluEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
NIGMS-funded disease modelers calculate that a vaccination program that reaches 70 percent of the U.S. population would control pandemic influenza H1N1. (Source: NIGMS - Results)
Source: NIGMS - Results - September 11, 2009 Category: Biomedical Science Source Type: news

Effects of auricular electrical stimulation on vagal activity in healthy men: Evidence from a three-armed randomized trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The activity of the vagus nerve is negatively associated with risk factors such as stress and smoking, morbidity, and mortality. In contrast it is also a target of therapeutic intervention. Vagus nerve stimulation is used in depression and epilepsy. Due to its high invasivity and exclusive application to therapy-resistant patients, there is interest in less invasive methods affecting the vagus nerve. Several studies examining acupuncture report beneficial effects on vagal activity. However, findings are inconsistent and applied methods are heterogeneous resulting in difficulties in interpretation. The purpose of the presen...
Source: Clinical Science - November 9, 2009 Category: Biomedical Science Authors: R La Marca, M Nedeljkovic, L Yuan, A Maercker, U Ehlert Source Type: journals

ProQuadEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Approval Letter and Approved Final Draft Labeling for Merck's Efficacy Supplement for Measles, Mumps, Rubella, and Varicella Vaccine, Live, (ProQuad®), to include concomitant administration with hepatitis A vaccine (VAQTA®) and/or pneumococcal conjugate vaccine (Prevnar®), use of ProQuad® in children 15 months to 12 years of age if a second dose of measles, mumps, rubella, and varicella is needed, additional safety data after a first or second dose of ProQuad®, and to comply with the Physician’s Labeling Rule format, have been issued. (Source: What's New at CBER)
Source: What's New at CBER - November 3, 2009 Category: Biomedical Science Source Type: organizations