Il-1 trap go-ahead
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IL-1 trap go-ahead
Nature Biotechnology 26, 485 (2008). doi:10.1038/nbt0508-485
Author: Mark Ratner (Source: Nature Biotechnology)
Source: Nature Biotechnology - May 17, 2008 Category: Biotechnology Authors: Mark Ratner Tags: News Source Type: journals
Current perspectives on stability of protein drug products during formulation, fill and finish operations
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Nitin Rathore and Rahul S. RajanWeb Release Date: Sat, 17 May 2008 00:00:00 EDT (Article) DOI: 10.1021/bp070462h (Source: Biotechnology Progress)
Source: Biotechnology Progress - May 17, 2008 Category: Biotechnology Source Type: journals
Antibacterial colorants: characterization of prodiginines and their applications on textile materials
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Farzaneh Alihosseini, Kou-San Ju, Jozsef Lango, Bruce D. Hammock, and Gang SunWeb Release Date: Sat, 17 May 2008 00:00:00 EDT (Article) DOI: 10.1021/bp070481r (Source: Biotechnology Progress)
Source: Biotechnology Progress - May 17, 2008 Category: Biotechnology Source Type: journals
Forum to tout biotech efforts
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Biotech 2008, a conference showcasing the top biotechnology companies and emerging startups from around North Carolina, will take place Monday and Tuesday in Winston-Salem, and will include a focus on efforts taking place outside Research Triangle Park. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - May 16, 2008 Category: Biotechnology Source Type: journals
Boston scientific heart failure treatment device gets fda approval
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The U.S. Food and Drug Administration has approved a device Boston Scientific Corp. has developed to help treat heart failure, the company announced Friday. (BSX) (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - May 16, 2008 Category: Biotechnology Source Type: journals
Labcorp launches new commercial test for prostate cancer
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Laboratory Corp. of America Holdings said Friday it will launch the first commercial gene methylation test for key tissue markers in prostate cancer. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - May 16, 2008 Category: Biotechnology Source Type: journals
Xanthus picked up by british firm antisoma for $52m
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Xanthus Pharmaceuticals Inc. reports it has agreed to be acquired by Antisoma plc, a U.K.-based biotechnology company, for $52.2 million. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - May 16, 2008 Category: Biotechnology Source Type: journals
Ceg hosts biotech forum in nyc
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The Center for Economic Growth Inc. is hosting a panel discussion on biotechnology in New York City. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - May 16, 2008 Category: Biotechnology Source Type: journals
Report says knowledge economy key to phila.-area's prosperity
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The Philadelphia metropolitan area continues to grow its knowledge economy and the region's educational level is increasing along with it, according to Select Greater Philadelphia's State of the Region report. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - May 16, 2008 Category: Biotechnology Source Type: journals
Wiring-up hydrogenase with single-walled carbon nanotubes.
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Wiring-Up Hydrogenase with Single-Walled Carbon Nanotubes.
Nano Lett. 2008 May 16;
Authors: McDonald TJ
PMID: 18481895 [PubMed - as supplied by publisher] (Source: Nano Letters)
Source: Nano Letters - May 16, 2008 Category: Biotechnology Authors: McDonald TJ Tags: Nano Lett Source Type: journals
Self-transducing silicon nanowire electromechanical systems at room temperature.
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Self-Transducing Silicon Nanowire Electromechanical Systems at Room Temperature.
Nano Lett. 2008 May 16;
Authors: He R, Feng XL, Roukes ML, Yang P
Electronic readout of the motions of genuinely nanoscale mechanical devices at room temperature imposes an important challenge for the integration and application of nanoelectromechanical systems (NEMS). Here, we report the first experiments on piezoresistively transduced very high frequency Si nanowire (SiNW) resonators with on-chip electronic actuation at room temperature. We have demonstrated that, for very thin ( approximately 90 nm down to approximately 30 nm) S...
Source: Nano Letters - May 16, 2008 Category: Biotechnology Authors: He R, Feng XL, Roukes ML, Yang P Tags: Nano Lett Source Type: journals
Substantially improved pharmacokinetics of recombinant human butyrylcholinesterase by fusion to human serum albumin
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Conclusion:
Both the pharmacokinetic study and the in vitro nerve agent binding and inhibition assay suggested that a fusion protein retaining both properties of huBChE and hSA is produced in vitro and in vivo. The production of the fusion protein in the milk of transgenic goats provided further evidence that sufficient quantities of BChE/hSA can be produced to serve as a cost-effective and reliable source of BChE for prophylaxis and post-exposure treatment. (Source: BMC Biotechnology - Latest articles)
Source: BMC Biotechnology - Latest articles - May 16, 2008 Category: Biotechnology Authors: Yue-Jin Huang, Paul M. Lundy, Anthoula Lazaris, Yue Huang, Hernan Baldassarre, Bin Wang, Carl Turcotte, Melanie Cote, Annie Bellemare, Annie S. Bilodeau, Sandra Brouillard, Madjid Touati, Peter Herskovits, Isabelle Begin, Nathalie Neveu, Eric Brochu, Jani Source Type: journals
Construction of a series of vectors for high throughput cloning and expression screening of membrane proteins from mycobacterium tuberculosis
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Conclusion:
This expression platform features high throughput cloning, high flexibility for different constructs, and high efficiency for membrane protein overexpression, and is expected to be useful in membrane protein structural and functional studies. (Source: BMC Biotechnology - Latest articles)
Source: BMC Biotechnology - Latest articles - May 16, 2008 Category: Biotechnology Authors: Huajun Qin, Jian Hu, Yuanzi Hua, Shridhar V Challa, Timothy A Cross and Fei P Gao Source Type: journals
Book review: graphics of large datasets. visualizing a million. by a. unwin, m. theus, and h. hofmann
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No Abstract (Source: Biometrical Journal)
Source: Biometrical Journal - May 16, 2008 Category: Biotechnology Authors: Dietrich Stoyan Source Type: journals
Biothreats workshop to take place in ws
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Clean Earth Technologies will partner with N.C. State University to put on the first annual Biothreat Agents (Bacillus) Workshop at the Piedmont Triad Research Park on May 28. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - May 15, 2008 Category: Biotechnology Source Type: journals
Stowers researchers find key genetic mutation in spinal defects
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Researchers at the Stowers Institute for Medical Research have helped identify a genetic mutation that causes congenital vertebral abnormalities in humans. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - May 15, 2008 Category: Biotechnology Source Type: journals
Duncan family gives $35m to m. d. anderson
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The Dan L. Duncan Family Foundation has given The University of Texas M.D. Anderson Cancer Center $35 million -- the institution's largest gift to its cancer prevention program and the second-largest gift in its 67-year history. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - May 15, 2008 Category: Biotechnology Source Type: journals
Fate finds new executive chairman in mendlein
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Less than a year from the sale of his Massachusetts life sciences firm, John Mendlein has been named executive chairman of biotech startup Fate Therapeutics Inc. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - May 15, 2008 Category: Biotechnology Source Type: journals
Lawyer e. stewart jones pledges $150k to ualbany's cancer research center
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Attorney E. Stewart Jones announced today that he is pledging $150,000 to support the University at Albany's Cancer Research Center. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - May 15, 2008 Category: Biotechnology Source Type: journals
The role of dynamic stimulation pattern in the analysis of bistable intracellular networks.
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Bistable systems play an important role in the functioning of living cells. Depending on the strength of the necessary positive feedback one can distinguish between (irreversible) "one-way switch" or (reversible) "toggle-switch" type behavior. Besides the well- established steady-state properties, some important characteristics of bistable systems arise from an analysis of their dynamics. We demonstrate that a supercritical stimulus amplitude is not sufficient to move the system from the lower (off-state) to the higher branch (on-state) for either a step or a pulse input. A switching surface is identified for the syste...
Source: Biosystems - May 15, 2008 Category: Biotechnology Authors: Millat T, Sreenath SN, Soebiyanto RP, Avva J, Cho KH, Wolkenhauer O Tags: Biosystems Source Type: journals
Coherently controlled ballistic charge currents injected in single-walled carbon nanotubes and graphite.
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Coherently Controlled Ballistic Charge Currents Injected in Single-Walled Carbon Nanotubes and Graphite.
Nano Lett. 2008 May 15;
Authors: Newson RW, Ménard JM, Sames C, Betz M, Driel HM
Ballistic electrical currents are optically injected into aligned single-walled carbon nanotubes and bulk graphite at 300 K via quantum interference between single and two photon absorption of phase-related 700 and 1400 nm, 150 fs pulses. The transient currents are detected via the emitted terahertz radiation. Optical phase and power dependence are consistent with the quantum interference optical process. Under similar ex...
Source: Nano Letters - May 15, 2008 Category: Biotechnology Authors: Newson RW, Ménard JM, Sames C, Betz M, Driel HM Tags: Nano Lett Source Type: journals
Residual pattern based test for interactions in two-way anova
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This article proposes a new test to detect interactions in replicated two-way ANOVA models, more powerful than the classical F -test and more general than the test of Terbeck and Davies (1998, Annals of Statistics 26, 1279-1305) developed for the case with unconditionally identifiable interaction pattern. We use the parameterization without the conventional restrictions on the interaction terms and base our test on the maximum of the standardized disturbance estimates. We show that our test is unbiased and consistent, and discuss how to estimate the p -value of the test. In a 3 × 3 case, which is our main focus in this ar...
Source: Biometrical Journal - May 15, 2008 Category: Biotechnology Authors: Wei Ning, Hyune-Ju Kim Source Type: journals
Simultaneous inference in general parametric models
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Simultaneous inference is a common problem in many areas of application. If multiple null hypotheses are tested simultaneously, the probability of rejecting erroneously at least one of them increases beyond the pre-specified significance level. Simultaneous inference procedures have to be used which adjust for multiplicity and thus control the overall type I error rate. In this paper we describe simultaneous inference procedures in general parametric models, where the experimental questions are specified through a linear combination of elemental model parameters. The framework described here is quite general and extends th...
Source: Biometrical Journal - May 15, 2008 Category: Biotechnology Authors: Torsten Hothorn, Frank Bretz, Peter Westfall Source Type: journals
Book review: angewandte statistik 1. by m. precht, r. kraft und m. bachmaier
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No Abstract (Source: Biometrical Journal)
Source: Biometrical Journal - May 15, 2008 Category: Biotechnology Authors: Ansgar Steland Source Type: journals
Book review: practical guide to clinical data management. by s. prokscha
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No Abstract (Source: Biometrical Journal)
Source: Biometrical Journal - May 15, 2008 Category: Biotechnology Authors: Daniele Compagnone Source Type: journals
Barshop institute director recognized nationally for aging research
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The director of the Sam and Ann Barshop Institute for Longevity and Aging Studies at the University of Texas Health Science Center at San Antonio has won a national honor from the American Federation for Aging Research. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - May 14, 2008 Category: Biotechnology Source Type: journals
Proventys raises $5.65m, hires ceo, strikes mckesson deal
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Personalized medicine company Proventys said Wednesday that it has closed on a $5.65 million round of venture financing, hired a new CEO and reached a deal with health-care giant McKesson. (MCK) (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - May 14, 2008 Category: Biotechnology Source Type: journals
Dose finding for continuous and ordinal outcomes with a monotone objective function: a unified approach
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Biometrics, Volume 0, Issue 0, Page ???, OnlineEarly Articles.
Summary. In many phase I trials, the design goal is to find the dose associated with a certain target toxicity rate. In some trials, the goal can be to find the dose with a certain weighted sum of rates of various toxicity grades. For others, the goal ... (Source: Biometrics)
Source: Biometrics - May 14, 2008 Category: Biotechnology Tags: article Source Type: journals
Three leaders to be inducted into tech valley business hall of fame
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Three business leaders are being inducted into the Tech Valley Business Hall of Fame on Thursday. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - May 14, 2008 Category: Biotechnology Source Type: journals
Ku hospital board supports cancer partners' name
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The University of Kansas Hospital's board of directors passed a resolution supporting a new name for an advisory board that will guide the region's cancer initiative. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - May 14, 2008 Category: Biotechnology Source Type: journals
Boston scientific gets fda ok for new heart implants
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Officials at Boston Scientific Corp. report that the U.S. Food and Drug Administration has granted the medical devices giant approvals for two new cardiac implants. (BSX) (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - May 14, 2008 Category: Biotechnology Source Type: journals
Una ryan steps down as avant ceo
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Biotech industry veteran Una Ryan is leaving her long-time post as CEO of Needham-based Avant Immunotherapeutics Inc., the company reports. (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - May 14, 2008 Category: Biotechnology Source Type: journals
Characterization of healthy skin using near infrared spectroscopy and skin impedance
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Abstract Near infrared spectroscopy (NIR) and skin impedance (IMP) spectroscopy are two methods suggested for diagnoses of diseases
inducing adverse effects in skin. The reproducibility of these methods and their potential value in non-invasive diagnostics
were investigated. Measurements were performed in vivo on healthy skin at five anatomic body sites on eight young women. partial
least squares discriminant analysis showed that both methods were useful for classification of the skin characteristics at
the sites. Inter-individually the NIR model gave 100% correct classification while the IMP model provided ...
Source: Medical and Biological Engineering and Computing - May 14, 2008 Category: Biotechnology Tags: Medical and Biological Engineering and Computing Source Type: journals
Finite difference iterative solvers for electroencephalography: serial and parallel performance analysis
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Abstract Currently the resolution of the head models used in electroencephalography (EEG) studies is limited by the speed of the forward
solver. Here, we present a parallel finite difference technique that can reduce the solution time of the governing Poisson
equation for a head model. Multiple processors are used to work on the problem simultaneously in order to speed up the solution
and provide the memory for solving large problems. The original computational domain is divided into multiple rectangular
partitions. Each partition is then assigned to a processor, which is responsible for all the computations...
Source: Medical and Biological Engineering and Computing - May 14, 2008 Category: Biotechnology Tags: Medical and Biological Engineering and Computing Source Type: journals
Performance of a new protein a affinity membrane for the primary recovery of antibodies
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Cristiana Boi, Simone Dimartino, and Giulio C. SartiWeb Release Date: Tue, 13 May 2008 00:00:00 EDT (Article) DOI: 10.1021/bp0704743 (Source: Biotechnology Progress)
Source: Biotechnology Progress - May 13, 2008 Category: Biotechnology Source Type: journals
Model-based geostatistics by gönen, m
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Biometrics, Volume 64, Issue 2, Page 659, June 2008. (Source: Biometrics)
Source: Biometrics - May 13, 2008 Category: Biotechnology Tags: book review Source Type: journals
Discussions
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Biometrics, Volume 64, Issue 2, Page 587-589, June 2008. (Source: Biometrics)
Source: Biometrics - May 13, 2008 Category: Biotechnology Tags: article Source Type: journals
Discussions
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Biometrics, Volume 64, Issue 2, Page 586-587, June 2008. (Source: Biometrics)
Source: Biometrics - May 13, 2008 Category: Biotechnology Tags: article Source Type: journals
Biometric practice
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Biometrics, Volume 64, Issue 2, Page 669, June 2008.
P. Bacchetti, C. E. McCulloch, and M. R. Segal 577 Simple, Defensible Sample Sizes Based on Cost Efficiency Il est d'usage de choisir une taille d'échantillon garantissant une puissance de test de 80% ou plus, sans prendre en compte le coût impliqué. ... (Source: Biometrics)
Source: Biometrics - May 13, 2008 Category: Biotechnology Tags: article Source Type: journals
Simple, defensible sample sizes based on cost efficiency
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Biometrics, Volume 64, Issue 2, Page 577-585, June 2008.
Summary. The conventional approach of choosing sample size to provide 80% or greater power ignores the cost implications of different sample size choices. Costs, however, are often impossible for investigators and funders to ignore in actual practice. ... (Source: Biometrics)
Source: Biometrics - May 13, 2008 Category: Biotechnology Tags: article Source Type: journals
Data clustering: theory algorithms and applications by gan, g., chaoqun, m. a., and wu, j
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Biometrics, Volume 64, Issue 2, Page 656-657, June 2008. (Source: Biometrics)
Source: Biometrics - May 13, 2008 Category: Biotechnology Tags: book review Source Type: journals
Information criteria and statistical modeling by konishi, s. and kitagawa, g
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Biometrics, Volume 64, Issue 2, Page 661, June 2008. (Source: Biometrics)
Source: Biometrics - May 13, 2008 Category: Biotechnology Tags: book review Source Type: journals
Modelling for field biologists and other interesting people by kokko, h
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Biometrics, Volume 64, Issue 2, Page 662, June 2008. (Source: Biometrics)
Source: Biometrics - May 13, 2008 Category: Biotechnology Tags: book review Source Type: journals
Discussions
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Biometrics, Volume 64, Issue 2, Page 589-591, June 2008. (Source: Biometrics)
Source: Biometrics - May 13, 2008 Category: Biotechnology Tags: article Source Type: journals
Model-based geostatistics by diggle, p. j. and ribeiro, p. j
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Biometrics, Volume 64, Issue 2, Page 653-654, June 2008. (Source: Biometrics)
Source: Biometrics - May 13, 2008 Category: Biotechnology Tags: book review Source Type: journals
Correction to "doubly robust estimation in missing data and causal inference models," by h. bang and j. m. robins; 61, 962–972, december 2005
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Biometrics, Volume 64, Issue 2, Page 650, June 2008. (Source: Biometrics)
Source: Biometrics - May 13, 2008 Category: Biotechnology Tags: article Source Type: journals
Model-based geostatistics by do, k.-a., müller, p., and vannucci, m
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Biometrics, Volume 64, Issue 2, Page 654-655, June 2008. (Source: Biometrics)
Source: Biometrics - May 13, 2008 Category: Biotechnology Tags: book review Source Type: journals
Rejoinder
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Biometrics, Volume 64, Issue 2, Page 592-594, June 2008. (Source: Biometrics)
Source: Biometrics - May 13, 2008 Category: Biotechnology Tags: article Source Type: journals
Applied asymptotics: case studies in small sample statistics by brazzale, a. r., davison, a. c., and reid, n
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Biometrics, Volume 64, Issue 2, Page 660, June 2008. (Source: Biometrics)
Source: Biometrics - May 13, 2008 Category: Biotechnology Tags: book review Source Type: journals
Reliability and risk: a bayesian perspective by singpurwalla, n. d
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Biometrics, Volume 64, Issue 2, Page 657-658, June 2008. (Source: Biometrics)
Source: Biometrics - May 13, 2008 Category: Biotechnology Tags: book review Source Type: journals
