Cancer & Oncology
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This page shows you the most recent publications within this specialty of the MedWorm directory.
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Prostatectomy modifications improve return of continence after surgery
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Anterior suspension combined with posterior reconstruction during robotic-assisted laparoscopic prostatectomy significantly improves the early return of continence in patients after surgery, report researchers. (Source: MedWire News - Prostate Cancer)
Source: MedWire News - Prostate Cancer - February 5, 2012 Category: Cancer & Oncology Source Type: news
Head and neck cancer carries substantial comorbidity burden
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People with head and neck cancer experience a high burden of both acute and chronic comorbidity, shows an analysis of a large Dutch population-based cohort. (Source: MedWire News - Oncology)
Source: MedWire News - Oncology - February 5, 2012 Category: Cancer & Oncology Source Type: news
Physical activity beneficial to cancer survivors
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Physical activity is associated with clinically important positive effects on physical function and quality of life in patients who have completed their treatment for cancer, results of a systematic review and meta-analysis show. (Source: MedWire News - Breast Cancer)
Source: MedWire News - Breast Cancer - February 5, 2012 Category: Cancer & Oncology Source Type: news
Adjuvant treatment of early colon cancer with micrometastases: Results of a national survey
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ConclusionsMM in colon cancer apparently influenced adjuvant treatment decisions absent known prognostic benefit. Prospective trials are needed to improve the selection of patients for systemic chemotherapy in early, node‐negative colon cancer. J. Surg. Oncol © 2012 Wiley Periodicals, Inc. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - February 5, 2012 Category: Cancer & Oncology Authors: Scott S. ShortAlexander StojadinovicAviram NissanZev WainbergDeepti DhallKathy YaoAnton Bilchik Tags: Research Article Source Type: research
Remarkable inhibition of mTOR signaling by the combination of rapamycin and 1,4‐phenylenebis(methylene)selenocyanate in human prostate cancer cells
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AbstractPreclinical studies and clinical analyses have implicated the mammalian target of rapamycin (mTOR) pathway in the progression of prostate cancer, suggesting mTOR as a potential target for new therapies. mTOR, a serine/threonine kinase, belongs to two distinct signaling complexes: mTORC1 and mTORC2. We previously showed that the synthetic organoselenium compound, p‐XSC, effectively inhibits viability and critical signaling molecules (e.g., androgen receptor, Akt) in androgen responsive (AR) and androgen independent (AI) human prostate cancer cells. Based on its inhibition of Akt, we hypothesized that p‐XSC modul...
Source: International Journal of Cancer - February 5, 2012 Category: Cancer & Oncology Authors: Nicole D. FacompreIndu SinhaKaram El‐BayoumyJohn T. PintoRaghu Sinha Tags: Cancer Therapy Source Type: research
Somatic mutations in the notch, NF‐KB, PIK3CA, and hedgehog pathways in human breast cancers
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AbstractExome sequencing of human breast cancers has revealed a substantial number of candidate cancer genes with recurring but infrequent somatic mutations. To determine more accurately their mutation prevalence, we performed a mutation analysis of 36 novel candidate cancer genes in 96 human breast cancers. Somatic mutations with potential impact on protein function were observed in the genes ADAM12, CENTB1, CENTG1, DIP2C, GLI1, GRIN2D, HDLBP, IKBKB, KPNA5, NFKB1, NOTCH1, and OTOF. These findings strengthen the evidence for involvement of the Notch, Hedgehog, NF‐KB, and PIK3CA pathways in breast cancer development, and ...
Source: Genes, Chromosomes and Cancer - February 5, 2012 Category: Cancer & Oncology Authors: Xiang JiaoLaura D. WoodMonica LindmanSian JonesPhillip BuckhaultsKornelia PolyakSaraswati SukumarHannah CarterDewey KimRachel KarchinTobias Sjöblom Tags: Research Article Source Type: research
Advances and New Research in the Treatment of Kidney Cancer
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CancerNetwork speaks with Dr. Michael Atkins, who has extensive clinical experience in kidney cancer and development of various new treatments, and is presenting this weekend during the renal cancer translational science session at the American Society of Clinical Oncology 2012 Genitourinary Cancers Symposium. (Source: Cancer Network)
Source: Cancer Network - February 5, 2012 Category: Cancer & Oncology Source Type: news
Population‐based survival for childhood cancer patients diagnosed during 2002–2005 in Shanghai, China
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ConclusionsThe survival rate for children aged 0–14 diagnosed with cancer in Shanghai during 2002–2005 was at the medium level. There was a substantial survival difference from childhood cancers between Shanghai and specific developed countries. Pediatr Blood Cancer © 2012 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - February 5, 2012 Category: Cancer & Oncology Authors: Ping‐ping BaoYing ZhengChun‐xiao WuPeng PengYang‐ming GongZhe‐zhou HuangWu Fan Tags: Research Article Source Type: research
Unclear methods in estimate of screening effect in women ages 40 to 49 years
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(Source: Cancer)
Source: Cancer - February 5, 2012 Category: Cancer & Oncology Authors: Karsten Juhl JørgensenPeter C. GYøtzsche Tags: Correspondence Source Type: research
Scientists target cholesterol to treat brain tumors
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(Source: Cancer)
Source: Cancer - February 5, 2012 Category: Cancer & Oncology Authors: Carrie Printz Tags: CancerScope Source Type: research
Depression in Latina survivors of breast cancer affects preventive health screening
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(Source: Cancer)
Source: Cancer - February 5, 2012 Category: Cancer & Oncology Authors: Carrie Printz Tags: CancerScope Source Type: research
Disparities in cancer care: Are we making progress?
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(Source: Cancer)
Source: Cancer - February 5, 2012 Category: Cancer & Oncology Authors: Carrie Printz Tags: CancerScope Source Type: research
Protumor activity of interleukin‐22 in HPAFII human pancreatic cancer cells
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In this report, we showed that IL‐22 stimulated production of vascular endothelial growth factor (VEGF) and the anti‐apoptotic factor Bcl‐XL in IL‐22R‐positive HPAFII human pancreatic cancer cells. Additionally, IL‐22 augmented HPAFII cell production of immunosuppressive cytokines. We further showed that IL‐22 activation of HPAFII cells diminished T cell production of IFN‐γ through the action of IL‐10. Strikingly, we showed for the first time that IL‐22 can fully protect cancer cells from NK cell‐mediated cytotoxicity by stimulating tumor production of IL‐10 and TGF‐β1. Our data supports the ide...
Source: Clinical and Experimental Immunology - February 5, 2012 Category: Allergy & Immunology Authors: L. M. CurdS. E. FavorsR. K. Gregg Source Type: research
Two glasses of wine a night triples risk of mouth cancer, Government warns
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Drinking two large glasses of wine a day triples the risk of developing mouth cancer, a government campaign will warn. (Source: Telegraph Health)
Source: Telegraph Health - February 5, 2012 Category: Consumer Health News Source Type: news
Battling Lung Cancer With Combination Drug Therapy
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Combination drug therapy may be needed to combat non-small cell lung cancer (NSCLC), according to a study by the Translational Genomics Research Institute (TGen) and Van Andel Research Institute (VARI). The study, "STAT3 is Activated by JAK2 Independent of Key Oncogenic Driver Mutation in Non-Small Cell Lung Carcinoma," was published online by the Public Library of Science (PLoS) ONE. The study found that in NSCLC - the most common form of lung cancer - that the STAT3 gene is activated in some NSCLC cell lines by the JAK2 protein... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 5, 2012 Category: Consumer Health News Tags: Lung Cancer Source Type: news
Best Treatment For TB Patients Could Be Determined By 'Goldilocks' Gene
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'Tuberculosis patients may receive treatments in the future according to what version they have of a single 'Goldilocks' gene, says an international research team from Oxford University, King's College London, Vietnam and the USA. This is one of the first examples in infectious disease of where an individual's genetic profile can determine which drug will work best for them - the idea of personalised medicine that is gradually becoming familiar in cancer medicine... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 5, 2012 Category: Consumer Health News Tags: Tuberculosis Source Type: news
Andrographolide sensitizes cisplatin-induced apoptosis via suppression of autophagosome-lysosome fusion in human cancer cells.
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In this study, we sought to examine the effect of Andro on autophagy, and to evaluate whether such effect is relevant to the sensitization effect of Andro on apoptosis induced by DNA damage agents in cancer cells. First, we found that Andro is able to significantly enhance autophagic markers in various cancer cell lines, including GFP-LC3 puncta and LC3-II level. Interestingly, Andro treatment also led to marked increase of p62 protein level and addition of chloroquine (CQ) failed to further enhance either LC3-II or p62 level, indicating that Andro is likely to suppress autophagic flux at the maturation and degradation sta...
Source: Autophagy - February 5, 2012 Category: Cytology Authors: Zhou J, Hu SE, Tan SH, Cao R, Chen Y, Xia D, Zhu X, Yang XF, Ong CN, Shen HM Tags: Autophagy Source Type: research
A novel method for autophagy detection in primary cells: Impaired levels of macroautophagy in immunosenescent T cells.
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Abstract
Autophagy is a conserved constitutive cellular process, responsible for the degradation of dysfunctional proteins and organelles. Autophagy plays a role in many diseases such as neurodegeneration and cancer; however, to date, conventional autophagy detection techniques are not suitable for clinical samples. We have developed a high throughput, statistically robust technique that quantitates autophagy in primary human leukocytes using the Image stream, an imaging flow cytometer. We validate this method on cell lines and primary cells knocked down for essential autophagy genes. Also, using this method we sho...
Source: Autophagy - February 5, 2012 Category: Cytology Authors: Phadwal K, Alegre-Abarrategui J, Watson AS, Pike L, Anbalagan S, Hammond EM, Wade-Martins R, McMichael A, Klenerman P, Simon AK Tags: Autophagy Source Type: research
Critical role of mTOR in calcineurin inhibitor-induced renal cancer progression.
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Abstract
Comment on: Basu A, et al. PLoS One 2011; 6:e23919.
PMID: 22293493 [PubMed - as supplied by publisher] (Source: Cell Cycle)
Source: Cell Cycle - February 5, 2012 Category: Cytology Authors: Basu A, Banerjee P, Pal S Tags: Cell Cycle Source Type: research
Lung Mass
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If you’ve been told that you have a lung mass, you probably feel confused and frightened. What might be the causes of a lung mass, and what can you expect in the days ahead? (Source: About.com Lung Cancer)
Source: About.com Lung Cancer - February 5, 2012 Category: Cancer & Oncology Authors: lungcancer.guide at about.com Tags: health Source Type: news
Colon Anatomy (Cross Section)
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The colon is about six feet long and is the part of the body's digestive system that moves waste material from the small intestine to the rectum. The colon is comprised of four distinct layers: the mucosa, the submucosa, the muscularis externa (two thick bands of muscle), and the serosa. Learn more about each in this colon anatomy gallery. (Source: About.com Colon Cancer)
Source: About.com Colon Cancer - February 5, 2012 Category: Cancer & Oncology Authors: coloncancer.guide at about.com Tags: health Source Type: news
Polyps
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A colon polyp is an abnormal growth in the lining of your colon. There are many different types of polyps, but only 10 percent of them will grow into colon cancer. Learn more about the types of polyps, the risk for colon cancer and how they are treated. (Source: About.com Colon Cancer)
Source: About.com Colon Cancer - February 5, 2012 Category: Cancer & Oncology Authors: coloncancer.guide at about.com Tags: health Source Type: news
endocrine therapies for breast cancer
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Estrogen receptor-positive breast cancer can be treated with endocrine therapies, also called hormonal therapies. These drugs come in two classes: selective estrogen receptor modulators (SERMs)and aromatase inhibitors. These lower your estrogen levels, and may affect your fertility, as well as preventing a recurrence of breast cancer. Learn more about endocrine therapies for breast cancer. (Source: About.com Breast Cancer)
Source: About.com Breast Cancer - February 5, 2012 Category: Cancer & Oncology Authors: breastcancer.guide at about.com Tags: health Source Type: news
Huber Needle
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Huber needles are used for IV chemotherapy. Your chemo nurse will use a Huber needle to access your implanted port. A Huber needle is designed for patient safety and comfort. Learn about Huber needles here. (Source: About.com Breast Cancer)
Source: About.com Breast Cancer - February 5, 2012 Category: Cancer & Oncology Authors: breastcancer.guide at about.com Tags: health Source Type: news
Comparability of cancer identification among death registry, cancer registry and hospital discharge registry
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In conclusion, some 10% of cancer deaths had no cancer records in CR or in HDR, and 3.4% were missing in both sources. The identification rate depended on tumor site, age at death, and, to some extent, death outside hospital. © 2012 Wiley‐Liss, Inc. (Source: International Journal of Cancer)
Source: International Journal of Cancer - February 5, 2012 Category: Cancer & Oncology Authors: Jianguang JiKristina SundquistJan SundquistKari Hemminki Tags: Epidemiology Source Type: research
How should individuals with a false‐positive fecal occult blood test for colorectal cancer be managed? A decision analysis
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In conclusion, the ContinueFOBT_long strategy was advantageous regarding both clinical benefit and required resources. Specifying an appropriate management strategy for individuals with a prior fpFOBT may substantially reduce required resources within a FOBT‐based CRC screening program without limiting its effectiveness. © 2012 Wiley‐Liss, Inc. (Source: International Journal of Cancer)
Source: International Journal of Cancer - February 5, 2012 Category: Cancer & Oncology Authors: Ulrike HaugAmy B. KnudsenKaren M. Kuntz Tags: Epidemiology Source Type: research
The association between two polymorphisms in the TS gene and risk of cancer: A systematic review and pooled analysis
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AbstractThymidylate synthase (TS) is an important enzyme involved in folate metabolism and catalyzes methylation of dUMP to dTMP, which is essential for DNA replication. TSER and TS1494del6, two functionally important and ethnically diverse polymorphisms mapping to its gene region, are the most extensively studied. Considering the potential influence of altering TS activity, it is plausible that TS polymorphisms might play a role in the development of cancer. Although the effects of TS polymorphisms on susceptibility to human cancer have been investigated in many studies, the results remain conflicting rather than conclusi...
Source: International Journal of Cancer - February 5, 2012 Category: Cancer & Oncology Authors: Jue‐Yu ZhouRong ShiHai‐Lang YuYe ZengWen‐Ling ZhengWen‐Li Ma Tags: Epidemiology Source Type: research
The prevalence of children affected by parental cancer and their use of specialised psychiatric services: The 1987 finnish birth cohort study
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This study examined the prevalence of children affected by parental cancer at national level and whether these children use specialised psychiatric services more than their peers. The study is a retrospective population‐based registry study. All 60,069 children born in Finland in 1987 were followed up with various health and social registers from 1987 to 2008. The associations of parental cancer treatments with children's psychiatric service use were analysed with logistic regressions. During the 21‐year follow‐up 3,909 (6.6%) of the children had a parent suffering from cancer. The children of the cancer patients use...
Source: International Journal of Cancer - February 5, 2012 Category: Cancer & Oncology Authors: Mika NiemeläReija PaananenHelinä HakkoMarko MerikukkaMika GisslerSami Räsänen Tags: Epidemiology Source Type: research
Aberrant expression of nuclear vimentin and related epithelial‐mesenchymal transition markers in nasopharyngeal carcinoma
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This study aimed to investigate the aberrant localization E‐cadherin, β‐catenin and vimentin, and their prognostic significance in 122 NPC patients by immunohistochemistry and immunofluorescence. Our results showed that both membranous and cytoplasmic localization of E‐cadherin staining were associated with lymph node metastasis (p = 0.000 and 0.005, respectively) and clinical stage (p = 0.000 and 0.007, respectively). High cytoplasmic β‐catenin correlated significantly with larger tumor size (p = 0.020), lymph node metastasis (p = 0.000) and advanced clinical stage (p = 0.036). However, no significant difference...
Source: International Journal of Cancer - February 5, 2012 Category: Cancer & Oncology Authors: Weiren LuoWeiyi FangSiyi LiKaitai Yao Tags: Early Detection and Diagnosis Source Type: research
'A little too much drink' warning
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Drinking "just a little more than they should" puts people at risk of serious illness including heart disease, stroke and cancer, the government is warning. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - February 4, 2012 Category: Consumer Health News Source Type: news
Cancer survivors line up as opponents in Super Bowl
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INDIANAPOLIS (Reuters) - There can only be one winner in Sunday's Super Bowl but for two opposing players, a bigger battle has already been won, victory over cancer. (Source: Reuters: Health)
Source: Reuters: Health - February 4, 2012 Category: Consumer Health News Tags: healthNews Source Type: news
Booze and Family History of Colon Cancer a Bad Mix: Study
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Red meat, smoking and skipping veggies also associated with a raised cancer risk, research finds (Source: Cancercompass News: Colorectal Cancer)
Source: Cancercompass News: Colorectal Cancer - February 4, 2012 Category: Cancer & Oncology Source Type: news
Soy Supplements May Not Shield Against Breast Cancer
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Study suggests no reduction in tumor risk, but one expert says more research may be needed (Source: Cancercompass News: Breast Cancer)
Source: Cancercompass News: Breast Cancer - February 4, 2012 Category: Cancer & Oncology Source Type: news
The Texas Tribune: Texans Lead Battle for Women’s Health
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In the skirmish between Susan G. Komen for the Cure and Planned Parenthood that intensified over the past week, all roads led to Texas. (Source: NYT)
Source: NYT - February 4, 2012 Category: American Health Authors: By EMILY RAMSHAW Tags: Komen, Susan G, for the Cure Planned Parenthood Federation of America Richards, Cecile Texas Brinker, Nancy Goodman Richards, Ann Boone, Cecilia Guthrie Breast Cancer Abortion Birth Control and Family Planning Women and Girls Source Type: news
The Texas Tribune: Texans Lead Battle for Women’s Health
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In the skirmish between Susan G. Komen for the Cure and Planned Parenthood that intensified over the past week, all roads led to Texas. (Source: NYT Health)
Source: NYT Health - February 4, 2012 Category: Consumer Health News Authors: By EMILY RAMSHAW Tags: Komen, Susan G, for the Cure Planned Parenthood Federation of America Richards, Cecile Texas Brinker, Nancy Goodman Richards, Ann Boone, Cecilia Guthrie Breast Cancer Abortion Birth Control and Family Planning Women and Girls Source Type: news
Hip replacement patients could face increased risk of cancer
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Fresh fears have been raised over the safety of hip replacements received by tens of thousands of British people. (Source: Telegraph Health)
Source: Telegraph Health - February 4, 2012 Category: Consumer Health News Source Type: news
On World Cancer Day, spotlight shines on prevention
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Today is World Cancer Day and this year's theme is "Together it is possible." (Source: CTV Health)
Source: CTV Health - February 4, 2012 Category: Consumer Health News Source Type: news
Silver packs a punch as chemotherapy drug
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Compounds of silver are as effective against breast and colon cancer cells as a leading chemotherapy drug and may result in fewer side effects (Source: New Scientist - Cancer)
Source: New Scientist - Cancer - February 4, 2012 Category: Cancer & Oncology Source Type: research
Silver packs a punch as chemotherapy drug
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Compounds of silver are as effective against breast and colon cancer cells as a leading chemotherapy drug and may result in fewer side effects (Source: New Scientist - Health)
Source: New Scientist - Health - February 4, 2012 Category: Consumer Health News Source Type: research
Exelixis' Cabozantinib Shows Encouraging Activity
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14.7 months median progression free survival; 28% confirmed partial response rate & 72% disease control rate at week 16.
02/05/2012 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - February 4, 2012 Category: Cancer & Oncology Source Type: news
Cost of cancer drug in Canada drops after court ruling
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A U.S. company that sells a thalidomide-based drug into Canada has agreed to lower the price of the medication. (Source: CTV Health)
Source: CTV Health - February 4, 2012 Category: Consumer Health News Source Type: news
Sleep Troubles May Up Prostate Cancer Risk
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SAN FRANCISCO (MedPage Today) -- Severe sleep problems suggestive of insomnia are associated with an increased risk of prostate cancer among older men, researchers found. (Source: MedPage Today Psychiatry)
Source: MedPage Today Psychiatry - February 4, 2012 Category: Psychiatry Source Type: news
Komen Reverses Stance on Planned Parenthood Grants
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The Susan G. Komen for the Cure foundation apologized for its decision to cut grants to Planned Parenthood for cancer screening and said it would restore the funding. (Source: NYT)
Source: NYT - February 4, 2012 Category: American Health Authors: By PAM BELLUCK, JENNIFER PRESTON and GARDINER HARRIS Tags: Komen, Susan G, for the Cure Planned Parenthood Federation of America Grants (Corporate and Foundation) Breast Cancer Abortion Stearns, Cliff Source Type: news
Soy Supplements May Not Shield Against Breast Cancer
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Study suggests no reduction in tumor risk, but one expert says more research may be needed (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - February 4, 2012 Category: Cancer & Oncology Authors: webmaster at doctorslounge.com Tags: Gynecology, Oncology, Alternative Medicine, Nutrition, News, Source Type: news
A novel method for fast and robust estimation of fluorescence decay dynamics using constrained least-squares deconvolution with Laguerre expansion.
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We report a novel method for estimating fluorescence impulse response function (fIRF) from noise-corrupted time-domain fluorescence measurements of biological tissue. This method is based on the use of high-order Laguerre basis functions and a constrained least-squares approach that addresses the problem of overfitting due to increased model complexity. The new method was extensively evaluated on fluorescence data from simulation, fluorescent standard dyes, ex vivo tissue samples of atherosclerotic plaques and in vivo oral carcinoma. Current results demonstrate that this method allows for rapid and accurate deconvolution o...
Source: Physics in Medicine and Biology - February 3, 2012 Category: Physics Authors: Liu J, Sun Y, Qi J, Marcu L Tags: Phys Med Biol Source Type: research
Thai cancer patient gets "last wish" wedding
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(Source: Monsters and Critics Health News)
Source: Monsters and Critics Health News - February 3, 2012 Category: Consumer Health News Source Type: news
Komen Reverses Stance on Planned Parenthood Grants
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The Susan G. Komen for the Cure foundation apologized for its decision to cut grants to Planned Parenthood for cancer screening and said it would restore the funding. (Source: NYT Health)
Source: NYT Health - February 3, 2012 Category: Consumer Health News Authors: By PAM BELLUCK, JENNIFER PRESTON and GARDINER HARRIS Tags: Komen, Susan G, for the Cure Planned Parenthood Federation of America Grants (Corporate and Foundation) Breast Cancer Abortion Stearns, Cliff Source Type: news
Hippocampal Drebrin Loss in Mild Cognitive Impairment
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Neurodegenerative Dis (DOI:10.1159/000333122) (Source: Karger Publishers)
Source: Karger Publishers - February 3, 2012 Category: Cancer & Oncology Source Type: research
Orbital Aspergillosis: Voriconazole – The New Standard Treatment?
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Case Rep Ophthalmol 2012;3:46–53 (DOI:10.1159/000336276) (Source: Karger Publishers)
Source: Karger Publishers - February 3, 2012 Category: Cancer & Oncology Source Type: research
Chronic Kidney Disease and End-Stage Renal Disease Predict Higher Risk of Mortality in Patients with Primary Upper Gastrointestinal Bleeding
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Am J Nephrol 2012;35:216–224 (DOI:10.1159/000336107) (Source: Karger Publishers)
Source: Karger Publishers - February 3, 2012 Category: Cancer & Oncology Source Type: research
