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This page shows you the most recent publications within this specialty of the MedWorm directory.

Editorial Board
(Source: Molecular Oncology)
Source: Molecular Oncology - May 23, 2013 Category: Cancer & Oncology Source Type: research

Over 75s with RCC represent unique subpopulation
Older adults with metastatic renal cell carcinoma are less likely to receive treatment, and have a poorer outcome than their younger peers, research suggests. (Source: MedWire News - Oncology)
Source: MedWire News - Oncology - May 23, 2013 Category: Cancer & Oncology Source Type: news

Reply to racial disparity in renal cell carcinoma patient survival according to demographic and clinical characteristics
(Source: Cancer)
Source: Cancer - May 23, 2013 Category: Cancer & Oncology Authors: Wong‐Ho Chow, W. Marston Linehan, Susan S. Devesa Tags: Correspondence Source Type: research

Comparison between poor and long‐term survivors with glioblastoma: Review of an Australian dataset
ConclusionReassuringly, no statistically significant socio‐demographic differences exist when comparing long‐term and poor survivors with glioblastoma. Patients surviving more than 2 years were significantly more likely to have participated in a clinical trial. This research could contribute towards informing further research on prognostic variables for patients with glioblastoma. (Source: Asia-Pacific Journal of Clinical Oncology)
Source: Asia-Pacific Journal of Clinical Oncology - May 23, 2013 Category: Cancer & Oncology Authors: Kathryn Maree Field, Mark Andrew Rosenthal, Merve Yilmaz, Mark Tacey, Kate Drummond Tags: ORIGINAL ARTICLE Source Type: research

Selective Ablation of Tumor‐Associated Macrophages (TAMs) Suppresses Metastasis and Angiogenesis
This article is protected by copyright. All rights reserved. (Source: Cancer Science)
Source: Cancer Science - May 23, 2013 Category: Cancer & Oncology Authors: Yingying Lin, Chongyang Wei, Yuan Liu, Yongming Qiu, Cheng Liu, Fang Guo Tags: Original Article Source Type: research

NANOG promotes liver cancer cell invasion by inducing epithelial-mesenchymal transition through NODAL/SMAD3 signaling pathway.
This study shows a significant correlation between the NANOG expression and the expression of NODAL, P-SMAD3 or SNAIL, and the combination of NANOG and P-SMAD3 is a potential predictor of poor prognosis of HCC. Additionally, cells in the tumor edge area displays higher NANOG expression than cells in the tumor center. These results present novel mechanistic insight into an important role of NANOG in HCC metastasis, and suggest a potential application of NANOG in HCC prognosis and treatment. PMID: 23474366 [PubMed - in process] (Source: The International Journal of Biochemistry and Cell Biology)
Source: The International Journal of Biochemistry and Cell Biology - May 23, 2013 Category: Biochemistry Authors: Sun C, Sun L, Jiang K, Gao DM, Kang XN, Wang C, Zhang S, Huang S, Qin X, Li Y, Liu YK Tags: Int J Biochem Cell Biol Source Type: research

P2X7R suppression promotes glioma growth through epidermal growth factor receptor signal pathway.
In conclusion, P2X7R suppression exerts a promoting effect on glioma growth, which is likely to be related to upregulated EGFR, HIF-1α and VEGF expression. These findings provide important clues to the molecular basis of anticancer effect of targeting purinergic receptors. PMID: 23523696 [PubMed - in process] (Source: The International Journal of Biochemistry and Cell Biology)
Source: The International Journal of Biochemistry and Cell Biology - May 23, 2013 Category: Biochemistry Authors: Fang J, Chen X, Zhang L, Chen J, Liang Y, Li X, Xiang J, Wang L, Guo G, Zhang B, Zhang W Tags: Int J Biochem Cell Biol Source Type: research

Ovarian cancer emerging subtypes: Role of oxidative stress and fibrosis in tumour development and response to treatment.
Abstract Epithelial ovarian cancer is a silent disease of usually late diagnosis and poor prognosis. Currently treatment options are limited and mainly consist of surgery followed by taxol- and platinum-based chemotherapy. Patient response to treatment is difficult to predict and there is a serious need for anticipating tumour response and orientating medical choices. In that aim, recent researches have focused on molecular aspects of ovarian tumours that could help patient stratification. We review here published discoveries in that field. We emphasize that signatures, defined by combining miRNA and transcriptomic...
Source: The International Journal of Biochemistry and Cell Biology - May 23, 2013 Category: Biochemistry Authors: Batista L, Gruosso T, Mechta-Grigoriou F Tags: Int J Biochem Cell Biol Source Type: research

ShRNA targeting Notch1 sensitizes breast cancer stem cell to paclitaxel.
In this study, we confirmed that paclitaxel enriched breast CSCs (CD44+/CD24-) in a dose-dependent manner in MCF-7 human breast cancer cell line. We then demonstrated that Notch1 was overexpressed in breast CSCs isolated from paclitaxel-treated MCF-7 cells compared to non-CSCs. The short hairpin RNA (shRNA) mediated knock-down of Notch1 inhibited MCF-7 cell proliferation and induced cell apoptosis. The anti-apoptosis protein NF-κB was decreased significantly when treated with shRNA-Notch1, and this effect was sharply improved by combination with paclitaxel. Paclitaxel decreased CD44+/CD24- cell population in MCF-7 cells a...
Source: The International Journal of Biochemistry and Cell Biology - May 23, 2013 Category: Biochemistry Authors: Mao J, Song B, Shi Y, Wang B, Fan S, Yu X, Tang J, Li L Tags: Int J Biochem Cell Biol Source Type: research

Adiponectin affects lung epithelial A549 cell viability counteracting TNFa and IL-1ß toxicity through AdipoR1.
Abstract Adiponectin (Acrp30) exerts protective functions on metabolic and cellular processes as energy metabolism, cell proliferation and differentiation by two widely expressed receptors, AdipoR1 and AdipoR2. To date, the biological role of Acrp30 in lung has not been completely assessed but altered levels of Acrp30 and modulated expression of both AdipoRs have been related to establishment and progression of chronic obstructive pulmonary disease (COPD) and lung cancer. Here, we investigated the effects of Acrp30 on A549, a human alveolar epithelial cell line, showing how, in a time and dose-dependent manner, it ...
Source: The International Journal of Biochemistry and Cell Biology - May 23, 2013 Category: Biochemistry Authors: Nigro E, Scudiero O, Sarnataro D, Mazzarella G, Sofia M, Bianco A, Daniele A Tags: Int J Biochem Cell Biol Source Type: research

15-Lipoxygenase-1/15-hydroxyeicosatetraenoic acid promotes hepatocellular cancer cells growth through protein kinase B and heat shock protein 90 complex activation.
Abstract Hepatocellular carcinoma is a typical hypervascular tumor resulted from excessive growth of tumor cells. Previous studies have demonstrated that the lipoxygenase is considered as a potential therapeutic target and have important influence on human cancers. However, whether the 15-lipoxygenase-1 (15-LO-1)/15-hydroxyeicosatetraenoic acid (15-HETE) pathway participates in the development and progression of hepatocellular carcinoma has not been reported until now. To test the hypothesis that the 15-LO-1/15-HETE signaling regulates hepatocellular carcinoma cells growth and metastasis via the phosphoinositide-3 ...
Source: The International Journal of Biochemistry and Cell Biology - May 23, 2013 Category: Biochemistry Authors: Ma J, Zhang L, Zhang J, Liu M, Wei L, Shen T, Ma C, Wang Y, Chen Y, Zhu D Tags: Int J Biochem Cell Biol Source Type: research

Breast Cancer Screening, Risk, and Options for High-Risk Women
We speak with two experts to discuss breast cancer risk, genetics, and prevention options available to women at high risk of developing breast and ovarian cancer. (Source: Cancer Network)
Source: Cancer Network - May 23, 2013 Category: Cancer & Oncology Source Type: news

Aveo says partner Astellas will not seek EU nod for kidney cancer drug
(Reuters) - Aveo Pharmaceuticals Inc said it was informed by its partner Astellas Pharma Inc that the Japanese company would not be seeking marketing approval for their experimental kidney cancer drug in Europe. (Source: Reuters: Health)
Source: Reuters: Health - May 23, 2013 Category: Consumer Health News Tags: healthNews Source Type: news

Sickness absence due to musculoskeletal diagnoses and risk of diagnosis-specific disability pension: A nationwide Swedish prospective cohort study
In conclusion, this nationwide cohort study reveals strongly increased risks of all-cause and diagnosis-specific disability pension among those sickness absent due to musculoskeletal diagnoses. (Source: Pain)
Source: Pain - May 23, 2013 Category: Anesthesiology Authors: Catarina Jansson, Kristina Alexanderson Tags: Research papers Source Type: research

Cellular localization of BARF1 oncoprotein and its cell stimulating activity in human epithelial cell.
Abstract BARF1 gene encoded by Epstein-Barr virus is capable of immortalizing the primary monkey epithelial cells and of inducing malignant transformation in human EBV-negative B cell lines as well as rodent fibroblast. This oncoprotein is a secreted protein capable of acting as a powerful mitogen. We have studied the effect of BARF1 protein in transfected or BARF1 protein treated human HaCaT epithelial cells. In BARF1-transfected cells, cell growth was activated and its protein was found both in culture medium and cellular compartment (membrane, cytoplasm and nuclei). When purified BARF1 protein was exogenously ad...
Source: Virus Research - May 23, 2013 Category: Virology Authors: Sakka E, Hausen AZ, Houali K, Liu H, Fiorini S, Ooka T Tags: Virus Res Source Type: research

Enrichment of stem-like cell population comprises transformation ability of Epstein-Barr virus latent membrane protein 2A for non-transformed cells.
Abstract Epstein-Barr virus (EBV) is a representative human oncogenic virus that causes malignancies of various cell lineages. LMP2A, an EBV-encoded latent membrane protein, is expressed in EBV-associated malignancies of various cell lineages. LMP2A caused visible tumor formation transplanted in nude mice when transferred to immortalized non-transformed fibroblasts, NIH3T3. LMP2A-expressing cells showed higher ability of colony formation in soft agar than empty vector-transfected control cells, although the expression of LMP2A did not cause focus transformation in low serum concentrations. LMP2A expression increase...
Source: Virus Research - May 23, 2013 Category: Virology Authors: Nakaya T, Kikuchi Y, Kunita A, Ishikawa S, Matsusaka K, Hino R, Aburatani H, Fukayama M Tags: Virus Res Source Type: research

More Patients Than Docs Report Skin Surgery ProblemsMore Patients Than Docs Report Skin Surgery Problems
More than one quarter of people being treated for non-melanoma skin cancer in their doctor's office reported some type of complication after surgery in a new study. Reuters Health Information (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 23, 2013 Category: Consumer Health News Tags: Dermatology News Source Type: news

BRCA Choices Not Affordable for Many US WomenBRCA Choices Not Affordable for Many US Women
Not everyone has superstar status: BRCA testing, counseling, and preventive options are simply out of reach for many US women. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 23, 2013 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

What's Hot at ASCO Annual Meeting This YearWhat's Hot at ASCO Annual Meeting This Year
There's already a buzz about immunotherapy and, among the new data that will be presented this year, there are 2 big trials with bevacizumab. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - May 23, 2013 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

[Strongyloidosis Caused Loeffler's Syndrome in an Immunosuppressed Patient Who Uses Cronic Steroid].
We report a case of Strongiloides stercoralis infection and Loeffler syndrome that developed in a patient who had systemıc prednisolone. Thepatient in the pulmonary disease department clinic was examined because of right lung upper lobe mass image, and referred to us with complaints of abdominal pain, diarrhea and pruritus. Peripheral smear showed 43% eosinophilia. Parasitological examination of faeces showed larvae of Strongyloides stercoralis. Parasitosis and Loeffler's syndrome was considered in the patient. Thepatient's complaints declined significantly after treatment with albendazole. (Turkiye Parazitol Derg 2013; 3...
Source: Turkish Society for Parasitology - May 23, 2013 Category: Parasitology Authors: Ekmekci OO, Tahmaz M, Altıparmak S, Gülaçtı G, Ergen AK, Kumbasar AB, Sepetcioğlu S, Oner YA Tags: Turkiye Parazitol Derg Source Type: research

Microbiology of hyper-arid environments: recent insights from the Atacama Desert, Chile.
Abstract Interests in the Atacama Desert of northern Chile until very recently were founded on its mineral resources, notably nitrate, copper, lithium and boron. Now this vast desert, the oldest and most arid on Earth, is revealing a microbial diversity that was unimagined even a decade or so ago; indeed the extreme hyper-arid core of the Desert was considered previously to be completely devoid of life. In this Perspective article we highlight pioneering research that, to the contrary, establishes the Atacama as a combination of rich microbial habitats including bacteria that influence biogeochemical transformation...
Source: Antonie van Leeuwenhoek - May 23, 2013 Category: Microbiology Authors: Bull AT, Asenjo JA Tags: Antonie Van Leeuwenhoek Source Type: research

Polymorphism in the Interleukin‐7 Receptor‐alpha and Outcome after Allogeneic Hematopoietic Cell Transplantation with Matched Unrelated Donor
In conclusion, this study provides further evidence of a role of the IL‐7 pathway and IL‐7Rα SNPs in HCT. This article is protected by copyright. All rights reserved. (Source: Scandinavian Journal of Immunology)
Source: Scandinavian Journal of Immunology - May 23, 2013 Category: Allergy & Immunology Authors: Zaiba Shamim, Stephen Spellman, Michael Haagenson, Tao Wang, Stephanie J. Lee, Lars P. Ryder, Klaus Müller Tags: Human Immunology Source Type: research

Characterization of novel CD55 isoforms expression in normal and neoplastic tissues
Abstract CD55 (decay‐accelerating factor, DAF) is overexpressed in several types of cancer, including colorectal cancer. Because of its inhibitory effect on the complement system, it has been suggested as a possible target for cancer immunotherapy. However, CD55 is also expressed in normal tissues, body fluids and stroma, limiting the use of anti‐CD55 therapeutic antibodies. Two novel CD55 splice variants or isoforms have recently been identified. These have been shown to contain part or all of intron 7 (CD55int7+), in contrast to the previously identified splice variants (CD55wt), which do not contain intron 7. Our ai...
Source: Tissue Antigens - May 23, 2013 Category: Allergy & Immunology Authors: E. D. Vainer, K. Meir, M. Furman, I. Semenenko, F. Konikoff, G. W. Vainer Tags: Original article Source Type: research

Personalized medicine in screening for malignant disease: a review of methods and applications.
Abstract Personalized medicine (PM) is currently a hot topic in the professional world. It is often called the medicine of the future and has already achieved resounding success in the area of targeted therapy. Nevertheless, integration of the concepts of PM into routine clinical practice is slow. This review is intended to give an overview of current and potential applications of PM in oncology. PM could soon play a decisive role, especially in screening. The relevance of PM in screening was examined in the case of four common cancers (colorectal cancer, lung cancer, breast cancer, and prostate cancer). A literatu...
Source: Biomarker Insights - May 23, 2013 Category: Journals (General) Authors: Schmalfuss F, Kolominsky-Rabas PL Tags: Biomark Insights Source Type: research

Scientists Can’t Replicate Surprising Finding on Alzheimer’s Treatment
Skin cancer drug had no effect on brain plaques in mice, three separate research teams report (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - May 23, 2013 Category: Cancer & Oncology Authors: webmaster at doctorslounge.com Tags: Neurology, Oncology, Pharmacy, News, Source Type: news

Dehydroepiandrosterone post-transcriptionally modifies CYP1A2 induction involving androgen receptor.
Abstract The pharmacological dosage of dehydroepiandrosterone (DHEA) protects against chemically induced carcinogenesis. The chemoprotective activity of DHEA is attributed to its inhibitory potential for the expression of CYP1A enzymes, which are highly responsible for metabolic activation of several mutagenic and carcinogenic chemicals. The present work investigated whether the chemoprevention by DHEA was due to diminished transcriptional activation of CYP1A genes or to the post-transcriptional modulation of CYP1A expression. In primary human hepatocytes, DHEA diminished the increase in CYP1A activities (7-ethoxyr...
Source: Chemico-Biological Interactions - May 23, 2013 Category: Molecular Biology Authors: Belic A, Tóth K, Vrzal R, Temesvári M, Porrogi P, Orbán E, Rozman D, Dvorak Z, Monostory K Tags: Chem Biol Interact Source Type: research

Tomatidine inhibits invasion of human lung adenocarcinoma cell A549 by reducing matrix metalloproteinases expression.
This study examines the effect of tomatidine on the migration and invasion of human lung adenocarcinoma A549 cell in vitro. The data demonstrates that tomatidine does not effectively inhibit the viability of A549 cells. When treated with non-toxic doses of tomatidine, cell invasion is markedly suppressed by Boyden chamber invasion assay, while cell migration is not affected. Tomatidine reduces the mRNA level of matrix metalloproteinase-2 (MMP-2), MMP-9 and increases the expression of reversion-inducing cysteine-rich protein with kazal motifs (RECK), as well as tissue inhibitor of metalloproteinase-1 (TIMP-1). The immunoblo...
Source: Chemico-Biological Interactions - May 23, 2013 Category: Molecular Biology Authors: Yan KH, Lee LM, Yan SH, Huang HC, Li CC, Lin HT, Chen PS Tags: Chem Biol Interact Source Type: research

2-Hydroxychalcone and xanthohumol inhibit invasion of triple negative breast cancer cells.
Abstract Breast cancer is estimated as one of the most common causes of cancer death among women. In particular, triple negative breast cancers (TNBCs), which do not express the genes for estrogen/progesterone receptors (ER/PR) and human epidermal growth factor receptor 2 (HER2), have been associated with poor prognosis and metastasis. Chalcones, the biosynthetic precursors of flavonoids present in edible plants, exert cytotoxic and chemopreventive activities. Although mounting evidence suggests the anticancer properties of chalcones, limited information is available regarding the inhibitory effects of chalcones on...
Source: Chemico-Biological Interactions - May 23, 2013 Category: Molecular Biology Authors: Kim SY, Lee IS, Moon A Tags: Chem Biol Interact Source Type: research

VIDEO: Managing Side Effects from Kidney Cancer Targeted Therapies
Watch the entire series of videos, ranging from about four to twelve minutes in length, each, to better understand how targeted therapies work and the side effects commonly experienced by patients using these treatments for disease management.05/23/2013 (Source: Kidney Cancer Association)
Source: Kidney Cancer Association - May 23, 2013 Category: Cancer & Oncology Source Type: news

APC loss-induced intestinal tumorigenesis in Drosophila: Roles of Ras in Wnt signaling activation and tumor progression.
Abstract Adenomatous polyposis coli (APC) and K-ras are the two most frequently mutated genes found in human colorectal cancers. In human colorectal cancers, Wnt signaling activation after the loss of APC is hypothesized to be the key event for adenoma initiation, whereas additional mutations such as Ras activation are required for the progression from adenoma to carcinoma. However, accumulating data have led to conflicting views regarding the precise role of Ras in APC loss-induced tumorigenesis. Here, using Drosophila midgut as a model system, we show that in the absence of Ras, APC mutant epithelial cells cannot...
Source: Developmental Biology - May 23, 2013 Category: Biology Authors: Wang C, Zhao R, Huang P, Yang F, Quan Z, Xu N, Xi R Tags: Dev Biol Source Type: research

Activated Cdc42 kinase regulates Dock localization in male germ cells during Drosophila spermatogenesis.
Abstract Deregulation of the non-receptor tyrosine kinase ACK1 (Activated Cdc42-associated kinase) correlates with poor prognosis in cancers and has been implicated in promoting metastasis. To further understand its in vivo function, we have characterized the developmental defects of a null mutation in Drosophila Ack, which bears a high degree of sequence similarity to mammalian ACK1 but lacks a CRIB domain. We show that Ack, while not essential for viability, is critical for sperm formation. This function depends on Ack tyrosine kinase activity and is required cell autonomously in differentiating male germ cells a...
Source: Developmental Biology - May 23, 2013 Category: Biology Authors: Abdallah AM, Zhou X, Kim C, Shah KK, Hogden C, Schoenherr JA, Clemens JC, Chang HC Tags: Dev Biol Source Type: research

Aggressive Prostate Cancer Treatment Not Needed in Older MenAggressive Prostate Cancer Treatment Not Needed in Older Men
Older men with newly diagnosed localized prostate cancer, especially those with other serious health conditions, are unlikely to derive benefit from aggressive treatment. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 23, 2013 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Well: Mothers With Cancer
Children of mothers with cancer must learn this painful lesson early: the vulnerability of the figure on whom they have grounded their existence. With varying degrees of fearful awareness, such children intuit that the mother who comforts by murmuring “I am here” will not always be there. (Source: NYT Health)
Source: NYT Health - May 23, 2013 Category: Consumer Health News Authors: By SUSAN GUBAR Tags: Cancer living with cancer Parenting Source Type: news

Labs reject dramatic findings on cancer drug in Alzheimer's mice
CHICAGO (Reuters) - U.S. scientists say a dramatic result last year suggesting that a cancer drug already approved by U.S. regulators could quickly clear out Alzheimer's plaques in mice was too good to be true. (Source: Reuters: Health)
Source: Reuters: Health - May 23, 2013 Category: Consumer Health News Tags: healthNews Source Type: news

New advice didn't change breast screening rates
NEW YORK (Reuters Health) - Women in their 40s didn't cut back on mammograms during 2010, the year after a government-backed panel said annual breast cancer screening should be optional for them, says a new study. (Source: Reuters: Health)
Source: Reuters: Health - May 23, 2013 Category: Consumer Health News Tags: healthNews Source Type: news

IL-6 restores dendritic cell maturation inhibited by tumor-derived TGF-β through interfering Smad 2/3 nuclear translocation.
In conclusion, IL-6 inhibited TGF-β signaling and concomitantly antagonized the suppression activities of TGF-β on DC maturation and activity. This study enables further understandings of host/cancer interactions an also provide hints facilitating improvements of DC-based cancer immunotherapy. PMID: 23579028 [PubMed - in process] (Source: Cytokine)
Source: Cytokine - May 23, 2013 Category: Molecular Biology Authors: Lin CS, Chen MF, Wang YS, Chuang TF, Chiang YL, Chu RM Tags: Cytokine Source Type: research

High tumor necrosis factor-α/interleukin-10 ratio is associated with hepatocellular carcinoma in patients with chronic hepatitis C.
Abstract Hepatitis C virus (HCV) is the main cause of chronic liver disease, cirrhosis and hepatocellular carcinoma (HCC) worldwide. The risk for the development of HCC increases with the severity of liver inflammation and fibrosis. The hepatic inflammation caused by HCV involves host regulatory immune response, which is mediated by cytokines with anti-viral role upon the interaction of viral polypeptides with innate and adaptive immunity. Two cytokines; tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) play key roles in the regulation of cellular immune response in HCV infection. The aim of the present ...
Source: Cytokine - May 23, 2013 Category: Molecular Biology Authors: Aroucha DC, do Carmo RF, Moura P, Silva JL, Vasconcelos LR, Cavalcanti MS, Muniz MT, Aroucha ML, Siqueira ER, Cahú GG, Pereira LM, Coêlho MR Tags: Cytokine Source Type: research

Frequent heartburn raises throat cancer risk 80 percent, study finds
Antacids, but not prescription heartburn medication, was found to protect against cancer risk (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - May 23, 2013 Category: Consumer Health News Source Type: news

Potential of the trifunctional bispecific antibody surek depends on dendritic cells: rationale for a new approach of tumor immunotherapy.
Abstract Trifunctional bispecific antibodies (trAbs) used in tumor immunotherapy have the unique ability to recruit T cells toward antigens on the tumor cell surface and, moreover, to activate accessory cells through their immunoglobulin Fc region interacting with activating Fcγ receptors. This scenario gives rise to additional costimulatory signals required for T cell-mediated tumor cell destruction and induction of an immunologic memory. Here we show in an in vitro system that most effective trAb-dependent T-cell activation and tumor cell elimination are achieved in the presence of dendritic cells (DCs). On the ...
Source: Molecular Medicine - May 23, 2013 Category: Molecular Biology Authors: Eissler N, Mysliwietz J, Deppisch N, Ruf P, Lindhofer H, Mocikat R Tags: Mol Med Source Type: research

Chronic Heartburn May Raise Odds for Throat Cancer: Study
But simple antacids appear to lower the risk, researchers report (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - May 23, 2013 Category: Cancer & Oncology Authors: webmaster at doctorslounge.com Tags: Gastroenterology, Oncology, News, Source Type: news

Investigating the cryoablative efficacy of a hybrid cryoprobe operating under freeze-thaw cycles.
Abstract Cryoprobes are minimally invasive tools that apply extremely low temperatures to eradicate undesirable cancerous tissue during cryosurgery. At times, they may generate thermal injury to neighboring good tissue leading to the case of over-ablation. The magnitude of this problem becomes significant when tumors are complex, large size and irregular in shape. In this work, we propose a simple yet pragmatic hybrid cryoprobe which can potentially promote better surgical efficacy by improving tumor ablation while reducing undesired thermal injury to the neighboring tissue. To evaluate the performance of the propo...
Source: Cryobiology - May 23, 2013 Category: Biology Authors: Zhao X, Chua KJ Tags: Cryobiology Source Type: research