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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 10.

Spleen endothelial cells from patients with myelofibrosis harbor the JAK2V617F mutation
In conclusion, we provide evidence that some ECs from the spleen and splenic veins of patients with MF bear the JAK2V617F mutation. We suggest that splenic ECs are involved in the process of malignant transformation in MF.
Source: Blood - January 10, 2013 Category: Hematology Authors: Rosti, V., Villani, L., Riboni, R., Poletto, V., Bonetti, E., Tozzi, L., Bergamaschi, G., Catarsi, P., Dallera, E., Novara, F., Massa, M., Campanelli, R., Fois, G., Peruzzi, B., Lucioni, M., Guglielmelli, P., Pancrazzi, A., Fiandrino, G., Zuffardi, O., Ma Tags: Myeloid Neoplasia Source Type: research

Heat shock protein 70 regulates Tcl1 expression in leukemia and lymphomas
T-cell leukemia/lymphoma 1 (TCL1) is an oncogene overexpressed in T-cell prolymphocytic leukemia and in B-cell malignancies including B-cell chronic lymphocytic leukemia and lymphomas. To date, only a limited number of Tcl1-interacting proteins that regulate its oncogenic function have been identified. Prior studies used a proteomic approach to identify a novel interaction between Tcl1 with Ataxia Telangiectasia Mutated. The association of Tcl1 and Ataxia Telangiectasia Mutated leads to activation of the NF-B pathway. Here, we demonstrate that Tcl1 also interacts with heat shock protein (Hsp) 70. The Tcl1-Hsp70 complex was...
Source: Blood - January 10, 2013 Category: Hematology Authors: Gaudio, E., Paduano, F., Ngankeu, A., Lovat, F., Fabbri, M., Sun, H.-L., Gasparini, P., Efanov, A., Peng, Y., Zanesi, N., Shuaib, M. A., Rassenti, L. Z., Kipps, T. J., Li, C., Aqeilan, R. I., Lesinski, G. B., Trapasso, F., Croce, C. M. Tags: Lymphoid Neoplasia Source Type: research

The constitutive androstane receptor is a novel therapeutic target facilitating cyclophosphamide-based treatment of hematopoietic malignancies
In this study, we have developed a unique human primary hepatocyte (HPH)–leukemia cell coculture model; the chemotherapeutic effects of CPA on leukemia cells can be directly investigated in vitro in a cellular environment where hepatic metabolism was well maintained. Our results demonstrated that activation of CAR preferentially induces the expression of CYP2B6 over CYP3A4 in HPHs, although endogenous expression of these enzymes in leukemia cells remains negligible. Importantly, coadministration of CPA with a human CAR activator led to significantly enhanced cytotoxicity in leukemia cells by inducing the apoptosis pa...
Source: Blood - January 10, 2013 Category: Hematology Authors: Wang, D., Li, L., Yang, H., Ferguson, S. S., Baer, M. R., Gartenhaus, R. B., Wang, H. Tags: Lymphoid Neoplasia Source Type: research

WT1-specific T-cell responses in high-risk multiple myeloma patients undergoing allogeneic T cell-depleted hematopoietic stem cell transplantation and donor lymphocyte infusions
We examined the significance of WT1-CTL responses in patients with relapsed MM and high-risk cytogenetics who were undergoing allogeneic T cell–depleted hematopoietic stem cell transplantation (alloTCD-HSCT) followed by donor lymphocyte infusions. Of 24 patients evaluated, all exhibited WT1-CTL responses before allogeneic transplantation. These T-cell frequencies were universally correlated with pretransplantation disease load. Ten patients received low-dose donor lymphocyte infusions beginning 5 months after transplantation. All patients subsequently developed increments of WT1-CTL frequencies that were associated w...
Source: Blood - January 10, 2013 Category: Hematology Authors: Tyler, E. M., Jungbluth, A. A., O'Reilly, R. J., Koehne, G. Tags: Immunobiology, Transplantation, Lymphoid Neoplasia Source Type: research

Inositol tetrakisphosphate limits NK cell effector functions by controlling PI3K signaling
Natural killer (NK) cells have important functions in cancer immunosurveillance, BM allograft rejection, fighting infections, tissue homeostasis, and reproduction. NK cell–based therapies are promising treatments for blood cancers. Overcoming their currently limited efficacy requires a better understanding of the molecular mechanisms controlling NK cell development and dampening their effector functions. NK cells recognize the loss of self-antigens or up-regulation of stress-induced ligands on pathogen-infected or tumor cells through invariant NK cell receptors (NKRs), and then kill such stressed cells. Two second-me...
Source: Blood - January 10, 2013 Category: Hematology Authors: Sauer, K., Park, E., Siegemund, S., French, A. R., Wahle, J. A., Sternberg, L., Rigaud, S., Jonsson, A. H., Yokoyama, W. M., Huang, Y. H. Tags: Immunobiology Source Type: research

Systemic delivery of a TLR7 agonist in combination with radiation primes durable antitumor immune responses in mouse models of lymphoma
Passive immunotherapy with monoclonal antibodies has improved outcome for patients with B-cell malignancies, although many still relapse and little progress has been made with T-cell malignancies. Novel treatment approaches are clearly required in this disease setting. There has been much recent interest in developing therapeutic approaches to enhance antitumor immune responses using novel immunomodulatory agents in combination with standard of care treatments. Here we report that intravenous administration of the Toll-like receptor 7 (TLR7) agonist, R848 in combination with radiation therapy (RT), leads to the longstandin...
Source: Blood - January 10, 2013 Category: Hematology Authors: Dovedi, S. J., Melis, M. H. M., Wilkinson, R. W., Adlard, A. L., Stratford, I. J., Honeychurch, J., Illidge, T. M. Tags: Immunobiology, Plenary Papers, Lymphoid Neoplasia Source Type: research

Clinical significance of overexpressed cyclin‐dependent kinase subunits 1 and 2 in esophageal carcinoma
Summary The mammalian cyclin‐dependent kinase subunit (Cks) family has two members, Cks1 and Cks2. Overexpression of Cks1 and Cks2 has been reported to be associated with high aggressiveness and poor prognosis in several malignancies, including prostate and hepatocellular carcinomas. However, whether Cks1 and Cks2 are overexpressed in esophageal carcinoma remains uncharacterized. To investigate whether overexpression of the Cks family is clinically relevant in esophageal carcinoma, and whether expression patterns of Cks1 and Cks2 can serve as biomarkers for esophageal carcinoma. Real‐time quantitative reverse transcrip...
Source: Diseases of the Esophagus - January 10, 2013 Category: Gastroenterology Authors: J.‐J. Wang, Z.‐X. Fang, H.‐M. Ye, P. You, M.‐J. Cai, H.‐B. Duan, F. Wang, Z.‐Y. Zhang Tags: Original article Source Type: research

Clinical characteristics of IPMN manifesting as acute pancreatitis or acute recurrent pancreatitis
ConclusionsAP/ARP caused by IPMN was of infrequent occurrence. AP/ARP caused by IPMN occurred more frequently in the main‐duct/combined type than in the branch‐duct type. Most cases were mild in severity and benign in histopathology. AP/ARP can be an initial manifestation of IPMN, though uncommon, which leads to diagnosis.
Source: Journal of Gastroenterology and Hepatology - January 10, 2013 Category: Gastroenterology Authors: Ji Woong Jang, Myung‐Hwan Kim, Seung Uk Jeong, Jeongseok Kim, Do Hyun Park, Sang Soo Lee, Dong‐Wan Seo, Sung‐Koo Lee, Jin Hee Kim Tags: Clinical Gastroenterology Source Type: research

Rapid on‐site evaluation by endosonographer during endoscopic ultrasound‐guided fine needle aspiration for pancreatic solid masses
ConclusionsThis cytological grading system used in ROSE by endosonographers is invaluable for diagnosis of pancreatic solid masses.
Source: Journal of Gastroenterology and Hepatology - January 10, 2013 Category: Gastroenterology Authors: Tsuyoshi Hayashi, Hirotoshi Ishiwatari, Makoto Yoshida, Michihiro Ono, Tsutomu Sato, Koji Miyanishi, Yasushi Sato, Masayoshi Kobune, Rishu Takimoto, Tomoko Mitsuhashi, Hiroko Asanuma, Jiro Ogino, Tadashi Hasegawa, Tomoko Sonoda, Junji Kato Tags: Clinical Gastroenterology Source Type: research

Does pre‐operative chemoradiation for initially unresectable or borderline resectable pancreatic adenocarcinoma increase post‐operative morbidity? A case‐matched analysis
ConclusionAlthough some previous studies have suggested differences in post‐operative morbidity after chemoradiation, our case‐matched analysis did not find statistical differences in surgical morbidity and mortality associated with pre‐operative chemoradiation therapy.
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - January 10, 2013 Category: Gastroenterology Authors: Raphael L. C. Araujo, Sébastien Gaujoux, Florence Huguet, Mithat Gonen, Michael I. D'Angelica, Ronald P. DeMatteo, Yuman Fong, T. Peter Kingham, William R. Jarnagin, Karyn A. Goodman, Peter J. Allen Tags: Original Article Source Type: research

Feasibility of the Glissonian approach during right hepatectomy
ConclusionsThe right Glissonian approach was effective in 75% of patients. Failure of the procedure (including the extension of clamping to the left pedicle) mostly occurred in patients with portal vein variations, which can be accurately assessed using a combination of preoperative imaging and intraoperative Doppler ultrasound.
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - January 10, 2013 Category: Gastroenterology Authors: Charlotte Mouly, David Fuks, François Browet, François Mauvais, Arnaud Potier, Thierry Yzet, Qassemyar Quentin, Jean‐Marc Regimbeau Tags: Original Article Source Type: research

Computed tomography attenuation and patient characteristics as predictors of complications after pancreaticoduodenectomy
ConclusionsPostoperative complications after PD remain prevalent. Decreased CT attenuation of abdominal viscera is an independent predictor of morbidity after PD and suggests a high‐risk patient physiology for pancreatic resection.
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - January 10, 2013 Category: Gastroenterology Authors: John C. McAuliffe, Karen Parks, Prakash Kumar, Sandre F. McNeal, Desiree E. Morgan, John D. Christein Tags: Original Article Source Type: research

Pancreaticoduodenectomy following chemoradiotherapy for locally advanced adenocarcinoma of the pancreatic head
ConclusionsIn patients with advanced pancreatic head adenocarcinoma, a good response after preoperative chemoradiotherapy results in a survival rate similar to that in patients treated with surgery alone in whom the initial prognosis is better.
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - January 10, 2013 Category: Gastroenterology Authors: Quentin Denost, Christophe Laurent, Jean‐Philippe Adam, Maylis Capdepont, Veronique Vendrely, Denis Collet, Antonio Sa Cunha Tags: Original Article Source Type: research

Renal cell carcinoma. Translational biology, personalized medicine and novel therapeutic targetsEditor(s) by Robert A. Figlin, W. Kimryn Rathmell & Brian I. Rini. Published by Springer, New York, USA, 2012. 327 pp, price $189.00, ISBN: 978‐1‐4614‐2399‐7
Source: British Journal of Clinical Pharmacology - January 10, 2013 Category: Drugs & Pharmacology Authors: Naveen S. Vasudev, James M. G. Larkin Tags: Book review Source Type: research

Pharmacokinetics of eribulin mesylate in patients with solid tumours receiving repeated oral rifampicin
ConclusionsThese results indicate that eribulin mesylate may be safely co‐administered with compounds that are CYP3A4 inducers.
Source: British Journal of Clinical Pharmacology - January 10, 2013 Category: Drugs & Pharmacology Authors: Lot A. Devriese, Petronella (Els) O. Witteveen, Jantien Wanders, Kenneth Law, Geoff Edwards, Larisa Reyderman, William Copalu, Fuping Peng, Serena Marchetti, Jos H. Beijnen, Alwin D. R. Huitema, Emile E. Voest, Jan H. M. Schellens Tags: Original Article Source Type: research

Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers
ConclusionThe results indicate that short term use of this piperine‐enhanced curcuminoid preparation is unlikely to result in a clinically significant interaction involving CYP3A, CYP2C9 or the paracetamol conjugation enzymes.
Source: British Journal of Clinical Pharmacology - January 10, 2013 Category: Drugs & Pharmacology Authors: Laurie P. Volak, Michael J. Hanley, Gina Masse, Suwagmani Hazarika, Jerold S. Harmatz, Vladimir Badmaev, Muhammed Majeed, David J. Greenblatt, Michael H. Court Tags: Pharmacokinetics Source Type: research

Double‐blind, randomized, placebo‐controlled study of safety, tolerability, pharmacokinetics and pharmacodynamics of TAK‐683, an investigational metastin analogue in healthy men
ConclusionsIn healthy men, s.c. administration of TAK‐683 was well tolerated at all dose levels. The PK profile of TAK‐683 was favourable, and TAK‐683 suppressed testosterone profoundly during continuous dosing. Further investigation of metastin analogues is warranted for the treatment of castration‐resistant prostate cancer.
Source: British Journal of Clinical Pharmacology - January 10, 2013 Category: Drugs & Pharmacology Authors: Graham Scott, Irfan Ahmad, Katy Howard, David MacLean, Cristina Oliva, Steve Warrington, Darren Wilbraham, Paul Worthington Tags: Clinical trials Source Type: research

Is the cardiovascular system a therapeutic target for cannabidiol?
Cannabidiol (CBD) has beneficial effects in disorders as wide ranging as diabetes, Huntington's disease, cancer and colitis. Accumulating evidence now also suggests that CBD is beneficial in the cardiovascular system. CBD has direct actions on isolated arteries, causing both acute and time‐dependent vasorelaxation. In vitro incubation with CBD enhances the vasorelaxant responses in animal models of impaired endothelium‐dependent vasorelaxation. CBD protects against the vascular damage caused by a high glucose environment, inflammation or the induction of type 2 diabetes in animal models and reduces the vascular hyperpe...
Source: British Journal of Clinical Pharmacology - January 10, 2013 Category: Drugs & Pharmacology Authors: Christopher P. Stanley, William H. Hind, Saoirse E. O'Sullivan Tags: Medical cannabidiol – is there anything it can't do? Source Type: research

Somatic mutations of STK11 gene in human papillomavirus positive and negative penile cancer
Conclusions: The present results suggest that single nucleotide mutations and/or deletions of STK11 gene are rare events in penile cancer. Moreover, no significant association was observed between STK11 alterations and HPV infection in these tumors.
Source: Infectious Agents and Cancer - January 10, 2013 Category: Cancer & Oncology Authors: Clorinda AnnunziataLuigi BuonaguroSimona LositoFranco BuonaguroMaria Lina Tornesello Source Type: research

Cohypermethylation of p14 in combination with CADM1 or DCC as a recurrence‐related prognostic indicator in stage I esophageal squamous cell carcinoma
CONCLUSIONS:The current results suggested that cohypermethylation of p14 in combination with DCC and/or CADM1 may be an independent prognostic factor for recurrence in patients with stage I ESCC. Cancer 2013;. © 2013 American Cancer Society.
Source: Cancer - January 10, 2013 Category: Cancer & Oncology Authors: Eunju Lee, Bo Bin Lee, Eunkyung Ko, Yujin Kim, Jungho Han, Young Mog Shim, Joobae Park, Duk‐Hwan Kim Tags: Original Article Source Type: research

Body mass index at diagnosis and survival among colon cancer patients enrolled in clinical trials of adjuvant chemotherapy
CONCLUSIONS:Obesity and underweight status were associated independently with inferior outcomes in patients with colon cancer who received treatment in adjuvant chemotherapy trials. Cancer 2013;. © 2013 American Cancer Society.
Source: Cancer - January 10, 2013 Category: Cancer & Oncology Authors: Frank A. Sinicrope, Nathan R. Foster, Greg Yothers, Al Benson, Jean Francois Seitz, Roberto Labianca, Richard M. Goldberg, Aimery DeGramont, Michael J. O'Connell, Daniel J. Sargent, Tags: Original Article Source Type: research

A phase 2 study of epothilone B analog BMS‐247550 (NSC 710428) in patients with relapsed aggressive non‐Hodgkin lymphomas
CONCLUSIONS:Ixabepilone was well‐tolerated, with neutropenia, peripheral sensory neuropathy, fatigue, and nausea as the major toxicities. Ixabepilone has modest single‐agent activity in patients with recurrent chemosensitive aggressive lymphomas. Cancer 2013;. © 2013 American Cancer Society.
Source: Cancer - January 10, 2013 Category: Cancer & Oncology Authors: Jane E. Churpek, Barbara Pro, Koen van Besien, Justin Kline, Kathy Conner, James L. Wade, Fredrick Hagemeister, Theodore Karrison, Sonali M. Smith Tags: Original Article Source Type: research

Beta‐Thalassemia Major: Does It Confer Particularities to the Breast?
Source: The Breast Journal - January 10, 2013 Category: Cancer & Oncology Authors: Garifalia Bletsa, Flora Zagouri, Antonia Gounaris, Dimosthenis Chrysikos, George Theodoropoulos, Maria Lymperi, Dimitra Koulocheri, Evangellos Menenakos, George C. Zografos, Theodoros N. Sergentanis Tags: Letter to the Editor Source Type: research

Developing a Breast Cancer‐Related Lymphedema Program: The William Beaumont Hospital Experience
Source: The Breast Journal - January 10, 2013 Category: Cancer & Oncology Authors: Chirag Shah, Chad Ermis, Frank Vicini Tags: Letter to the Editor Source Type: research

Apocrine Cystadenoma Of the Axillary Tail of the Breast
Source: The Breast Journal - January 10, 2013 Category: Cancer & Oncology Authors: Enaam Junainah, Hind Khayat, Shefaa Al‐ Amoudi, Saad Al‐ Awwad, Sahar Bannani, Muna Baslaim Tags: Breast Image Source Type: research

Oncological Advantages of Oncoplastic Breast‐Conserving Surgery in Treatment of Early Breast Cancer
Abstract The standard approach to breast‐conserving surgery is wide local excision of the tumor and radiotherapy. However, a significant number of patients require further surgery to obtain oncologically clear margins, and may obtain a poor cosmetic result following adjuvant radiotherapy. Oncoplastic techniques may result in improved cosmesis, but few studies have investigated the oncological advantage of this approach. The aim of this retrospective study was to compare tumor clearance and the need for further margin excision following standard wide local excision (group A, 121 patients), and oncoplastic breast‐conserv...
Source: The Breast Journal - January 10, 2013 Category: Cancer & Oncology Authors: Sue K. Down, Pankaj K. Jha, Amy Burger, Maged I. Hussien Tags: Original Article Source Type: research

Large Core Needle Biopsy with Tomosynthesis Guidance: Another Development in Breast Imaging Technology
Source: The Breast Journal - January 10, 2013 Category: Cancer & Oncology Authors: D David Dershaw Tags: Editorial Source Type: research

Correction
Source: Cancer Science - January 10, 2013 Category: Cancer & Oncology Tags: Correction Source Type: research

Preliminary Page
Source: Cancer Science - January 10, 2013 Category: Cancer & Oncology Tags: Preliminary Page Source Type: research

MiR‐150 regulates the EMT‐inducer ZEB1 in esophageal squamous cell carcinoma. Wound healing assays of premiR‐150‐treated esophageal squamous cell carcinoma TE‐8 cells
Source: Cancer Science - January 10, 2013 Category: Cancer & Oncology Authors: Takehiko Yokobori, Shigemasa Suzuki, Naritaka Tanaka, Takanori Inose, Makoto Sohda, Akihiko Sano, Makoto Sakai, Masanobu Nakajima, Tatsuya Miyazaki, Hiroyuki Kato, Hiroyuki Kuwano Tags: Cover Image Source Type: research

Hedgehog Gli3 activator signal augments tumorigenicity of colorectal cancer via upregulation of adherence‐related genes
In conclusion, activator Gli3 signal augments tumorigenicity of colorectal cancer irrespective of p53 status.
Source: Cancer Science - January 10, 2013 Category: Cancer & Oncology Authors: Hironori Iwasaki, Kenji Nakano, Kentaro Shinkai, Yumi Kunisawa, Minako Hirahashi, Yoshinao Oda, Hideya Onishi, Mitsuo Katano Tags: Original Article Source Type: research

Foxp3+ regulatory T cells coexisting with cancer associated fibroblast are correlated with a poor outcome in lung adenocarcinoma
Summary Recently, an association between tumor infiltrating Foxp3+ regulatory T cells (Tregs) and an unfavorable prognosis has been clinically shown in some cancers, but the mechanism of Treg induction in the tumor microenvironment remains uncertain. The aims of the present study were to examine the relationship between Tregs and the patient outcome and to investigate whether Treg induction is influenced by the characteristics of cancer‐associated fibroblasts (CAFs) in lung adenocarcinoma. The numbers of Tregs in both the tumor stroma and the tumor nest were counted in 200 consecutive pathological stage I lung invasive a...
Source: Cancer Science - January 10, 2013 Category: Cancer & Oncology Authors: Tomonari Kinoshita, Genichiro Ishii, Nobuyoshi Hiraoka, Shunki Hirayama, Chisako Yamauchi, Keiju Aokage, Tomoyuki Hishida, Junji Yoshida, Kanji Nagai, Atsushi Ochiai Tags: Original Article Source Type: research

Low cyclin F expression in hepatocellular carcinoma associates with poor differentiation and unfavorable prognosis
In this study, we showed that cyclin F was noticeably decreased in 16 pairs of tissue samples of hepatocellular carcinoma (HCC), compared to paracarcinoma tissues, at both mRNA and protein levels. Immunohistochemical staining data revealed that in 71.8% (176/245) of HCC cases, cyclin F expression in tumor tissue was much lower than that in nontumorous tissue. Low cyclin F expression, defined by receiver operating characteristic curve (ROC) analysis, was present in 69.0% of HCC patients. Low expression of cyclin F significantly correlated with tumor size, clinical stage, serum AFP level and tumor multiplicity. Further study...
Source: Cancer Science - January 10, 2013 Category: Cancer & Oncology Authors: Jia Fu, Huijuan Qiu, Muyan Cai, Yinghua Pan, Yun Cao, Lili Liu, Jingping Yun, Chris Zhiyi Zhang Tags: Original Article Source Type: research

Anti‐angiogenic and anti‐tumor effects of TAK‐593, a potent and selective inhibitor of VEGF and PDGF receptor tyrosine kinase
In conclusion, TAK‐593 is an extremely potent VEGFR/PDGFR kinase inhibitor whose potent anti‐angiogenic activity suggests therapeutic potential for the treatment of solid tumors.
Source: Cancer Science - January 10, 2013 Category: Cancer & Oncology Authors: Yoshiko Awazu, Akio Mizutani, Yoshinori Nagase, Shuntarou Tsuchiya, Kazuhide Nakamura, Yuichi Kakoi, Osamu Kitahara, Toshiyuki Takeuchi, Seiji Yamasaki, Naoki Miyamoto, Hidehisa Iwata, Hiroshi Miki, Shin‐ichi Imamura, Akira Hori Tags: Original Article Source Type: research

A population-based cross-sectional study of colorectal cancer screening practices of first-degree relatives of colorectal cancer patients
Conclusions: A significant level of non-compliance with screening guidelines was evident among FDRs. Improved CRC screening in accordance with guidelines and effective systematic interventions to increase screening rates among population groups experiencing inequality are needed.Australian and New Zealand Clinical Trial Registry: ACTRN12609000628246
Source: BMC Cancer - January 10, 2013 Category: Cancer & Oncology Authors: Ryan CourtneyChristine PaulMariko CareyRobert Sanson-FisherFinlay MacraeCatherine D¿EsteDavid HillDaniel BarkerJody Simmons Source Type: research

Functional significance of erythropoietin in renal cell carcinoma
One of the molecules regulated by the transcription factor, hypoxia inducible factor (HIF), is the hypoxia-responsive hematopoietic factor, erythropoietin (EPO). This may have relevance to the development of renal cell carcinoma (RCC), where mutations of the von Hippel-Lindau (VHL) gene are major risk factors for the development of familial and sporadic RCC. VHL mutations up-regulate and stabilize HIF, which in turn activates many downstream molecules, including EPO, that are known to promote angiogenesis, drug resistance, proliferation and progression of solid tumours. HIFs typically respond to hypoxic cellular environmen...
Source: BMC Cancer - January 10, 2013 Category: Cancer & Oncology Authors: Christudas MoraisDavid JohnsonDavid VeseyGlenda Gobe Source Type: research

Molecular profiles of screen detected vs. symptomatic breast cancer and their impact on survival: results from a clinical series
Conclusions: Molecular subtypes did not substantially explain the differences in survival outcomes between screened and symptomatic patients. However, our results suggest that molecular profiles might play a role in interpreting such differences at least partially.Further studies are warranted to reinterpret the efficacy of screening programmes in the light of tumour biology.
Source: BMC Cancer - January 10, 2013 Category: Cancer & Oncology Authors: Anna CrispoMaddalena BarbaGiuseppe D¿AiutoMichelino De LaurentiisMaria GrimaldiMassimo RinaldoGiuseppina CaoloMassimiliano D¿AiutoImmacolata CapassoEmanuela EspositoAlfonso AmoreMaurizio Di BonitoGerardo BottiMaurizio Montella Source Type: research

Consistent performance measurement of a system to detect masses in mammograms based on blind feature extraction
Conclusions: Considering the heterogeneity in the datasets used to train and test our system in each case, we think that the variation of performance obtained when the results are compared with the overall results is acceptable in both cases, for NN and SVM classifiers. The present method is therefore very general in that it is able to adapt to different clinical situations and provide consistent performance.
Source: BioMedical Engineering OnLine - January 10, 2013 Category: Biomedical Engineering Authors: Antonio García-MansoCarlos García-OrellanaHoracio González-VelascoRamón Gallardo-CaballeroMiguel Macías-Macías Source Type: research

The art of gene therapy for glioma: a review of the challenging road to the bedside
Glioblastoma multiforme (GBM) is a highly invasive brain tumour that is unvaryingly fatal in humans despite even aggressive therapeutic approaches such as surgical resection followed by chemotherapy and radiotherapy. Unconventional treatment options such as gene therapy provide an intriguing option for curbing glioma related deaths. To date, gene therapy has yielded encouraging results in preclinical animal models as well as promising safety profiles in phase I clinical trials, but has failed to demonstrate significant therapeutic efficacy in phase III clinical trials. The most widely studied antiglioma gene therapy strate...
Source: Journal of Neurology, Neurosurgery and Psychiatry - January 10, 2013 Category: Neurosurgery Authors: Tobias, A., Ahmed, A., Moon, K.-S., Lesniak, M. S. Tags: Editor's choice, Immunology (including allergy), Neurooncology, CNS cancer, Suicide (psychiatry), Radiology Neuro-oncology Source Type: research

No association between XMRV or related gammaretroviruses in Australian prostate cancer patients
Conclusions: Using highly sensitive qPCR we found no evidence of XMRV or related gammaretroviruses in prostate tissues from 35 Australian PC patients. Our findings are consistent with other studies demonstrating that XMRV is a laboratory contaminant that has no role in the aetiology of PC.
Source: Virology Journal - January 10, 2013 Category: Virology Authors: Simin RezaeiAnna HearpsJohn MillsJohn PedersenGilda Tachedjian Source Type: research

Segmental dosimetry, toxicity and long‐term outcome in patients with prostate cancer treated with permanent seed implants
Conclusions We could not demonstrate a correlation of segmental dosimetry with induction of side effects. There is no relationship between dose exposure of partial volumes and the development of radiation‐induced toxicities. The preoperative situation regarding lower urinary tract symptoms and erectile function are the most important factors for postoperative outcome.
Source: BJU International - January 10, 2013 Category: Urology & Nephrology Authors: Andreas Meyer, Julia Wassermann, Antje Warszawski‐Baumann, Rolf Baumann, Stefan Machtens, Johann H. Karstens, Hans Christiansen, Axel Merseburger, Markus A. Kuczyk, Christoph Klot Tags: Urological Oncology Source Type: research

Acquired resistance to sunitinib in human renal cell carcinoma cells is mediated by constitutive activation of signal transduction pathways associated with tumour cell proliferation
Conclusion The maintenance of protein kinase activation during sunitinib treatment may be involved in the acquisition of resistant phenotype to sunitinib in RCC cells.
Source: BJU International - January 10, 2013 Category: Urology & Nephrology Authors: Iori Sakai, Hideaki Miyake, Masato Fujisawa Tags: Translational Science Source Type: research

Robot‐assisted reconstructive surgery of the distal ureter: single institution experience in 16 patients
Conclusions Robot‐assisted reconstructive surgery of the distal ureter is feasible and can be used without compromising the generally accepted principles of open surgical procedures. The functional outcome was good in short‐term follow‐up and severe postoperative complications were rare.
Source: BJU International - January 10, 2013 Category: Urology & Nephrology Authors: Michael Musch, Lukas Hohenhorst, Anne Pailliart, Heinrich Loewen, Yadollah Davoudi, Darko Kroepfl Tags: Robotics and Laparoscopy Source Type: research

Prevalence and impact on survival of positive surgical margins in partial nephrectomy for renal cell carcinoma: a population‐based study
Conclusion Our population‐level data suggest that, although PSMs are fairly prevalent, they appear to have little to no impact on 5‐year survival rates.
Source: BJU International - January 10, 2013 Category: Urology & Nephrology Authors: Ifeanyi Ani, Antonio Finelli, Shabbir M.H. Alibhai, Narhari Timilshina, Neil Fleshner, Robert Abouassaly Tags: Urological Oncology Source Type: research

Diabetes predicts metastasis after radical prostatectomy in obese men: results from the SEARCH database
Conclusions Diabetes was not associated with metastasis risk overall. Stratification by obesity yielded significant differences, with diabetes linked to a fourfold higher metastasis risk in obese men, despite predicting more aggressive secondary treatment. Longer diabetes duration was also associated with increased metastasis risk.
Source: BJU International - January 10, 2013 Category: Urology & Nephrology Authors: Chenwei Wu, William J. Aronson, Martha K. Terris, Joseph C. Presti, Christopher J. Kane, Christopher L. Amling, Stephen J. Freedland Tags: Urological Oncology Source Type: research

Ki‐67, mini‐chromosome maintenance 2 protein (MCM2) and geminin have no independent prognostic relevance for cancer‐specific survival in surgically treated squamous cell carcinoma of the penis
Conclusions At present, conventional histopathological criteria remain the most powerful predictors of CSS in surgically treated SCCP. Due to overlapping staining profiles, Ki‐67, MCM2 and geminin, either singly or in various combinations, failed to immunohistochemically refine the boundaries between Broders' grading categories. Ki‐67, MCM2 and geminin do not represent independent prognostic parameters but reflect a more aggressive behaviour in surgically treated SCCP. Further studies are needed to clarify the currently contradictory predictive role of proliferation‐associated biomarkers in terms of predicting nodal ...
Source: BJU International - January 10, 2013 Category: Urology & Nephrology Authors: Matthias May, Maximilian Burger, Wolfgang Otto, Oliver W. Hakenberg, Wolf F. Wieland, Dieter May, Ferdinand Hofstädter, Stefanie Götz, Nina Niessl, Hans‐Martin Fritsche, Kristina Birnkammer, Christian Gilfrich, Julia Peter, Anjun Jain, Stefan Koch, St Tags: Translational Science Source Type: research

Men's experiences of regaining urinary continence following robotic‐assisted laparoscopic prostatectomy (RALP) for localised prostate cancer: a qualitative phenomenological study
ConclusionThe need to regain a sense of control over their lives resulted in all men developing coping mechanisms in order that they could resume their societal roles, which were salient to their personal identity, inferring that men's ability to cope with incontinence after RALP was dependent on factors other than urinary leakage alone. Relevance to clinical practiceKnowledge of the potential impact of RALP could help nurses tailor appropriate interventions. Incontinence is individually interpreted and may not be well‐addressed by traditional ‘one‐size fits all’ preoperative programmes or information. Flexible and...
Source: Journal of Clinical Nursing - January 10, 2013 Category: Nursing Authors: Jo Waller, Natalie Pattison Tags: INCONTINENCE Source Type: research

Molecular conformation changes along the malignancy revealed by optical nanosensors
Abstract An interdisciplinary approach employing functionalized nanoparticles and ultrasensitive spectroscopic techniques is reported here to track the molecular changes in early stage of malignancy. Melanoma tissue tracking at molecular level using both labelled and unlabelled silver and gold nanoparticles has been achieved using surface enhanced Raman scattering (SERS) technique. We used skin tissue from ex vivo mice with induced melanoma. Raman and SERS molecular characterization of melanoma tissue is proposed here for the first time. Optical nanosensors based on Ag and Au nanoparticles with chemisorbed cresyl violet mo...
Source: Journal of Cellular and Molecular Medicine - January 10, 2013 Category: Molecular Biology Authors: Simona Cinta Pinzaru, Alexandra Falamas, Cristina Adriana Dehelean Tags: Original Article Source Type: research

Hypoxia‐inducing factors as master regulators of stemness properties and altered metabolism of cancer‐ and metastasis‐initiating cells
Abstract Accumulating lines of experimental evidence have revealed that hypoxia‐inducible factors, HIF‐1α and HIF‐2α, are key regulators of the adaptation of cancer‐ and metastasis‐initiating cells and their differentiated progenies to oxygen and nutrient deprivation during cancer progression under normoxic and hypoxic conditions. Particularly, the sustained stimulation of epidermal growth factor receptor (EGFR), insulin‐like growth factor‐1 receptor (IGF‐1R), stem cell factor (SCF) receptor KIT, transforming growth factor‐β receptors (TGF‐βRs) and Notch and their downstream signalling elements such...
Source: Journal of Cellular and Molecular Medicine - January 10, 2013 Category: Molecular Biology Authors: Murielle Mimeault, Surinder K. Batra Tags: Review Article Source Type: research

Bone marrow mesenchymal stem cells increase motility of prostate cancer cells via production of stromal cell‐derived factor‐1α
Abstract Prostate cancer frequently metastasizes to the bone, and the interaction between cancer cells and bone microenvironment has proven to be crucial in the establishment of new metastases. Bone marrow mesenchymal stem cells (BM‐MSCs) secrete various cytokines that can regulate the behaviour of neighbouring cell. However, little is known about the role of BM‐MSCs in influencing the migration and the invasion of prostate cancer cells. We hypothesize that the stromal cell‐derived factor‐1α released by BM‐MSCs may play a pivotal role in these processes. To study the interaction between factors secreted by BM‐...
Source: Journal of Cellular and Molecular Medicine - January 10, 2013 Category: Molecular Biology Authors: Barbara Mognetti, Giuseppe La Montagna, Maria Giulia Perrelli, Pasquale Pagliaro, Claudia Penna Tags: Original Article Source Type: research