Cancer & Oncology Research This is an OPML file. It can be used to export all the MedWorm RSS feeds on this topic into your personal RSS reader (usually you have to save this file to your own computer before clicking on an Import OPML command in your own feed reader to upload the file which will then import all the feeds) or it can be used by webmasters to integrate MedWorm feeds with their own website. This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 29.

Multiparameter DNA content analysis identifies distinct groups in primary breast cancer
att & A M Thompson
Source: British Journal of Cancer AOP - February 14, 2013 Category: Cancer & Oncology Authors: J H S DayalM J SalesW E CorverC A PurdieL B JordanP R QuinlanL BakerN T ter HaarN R PrattA M Thompson Source Type: research

Docetaxel plus cetuximab as second-line treatment for docetaxel-refractory oesophagogastric cancer: the AGITG ATTAX2 trial
rovic & V J Gebski
Source: British Journal of Cancer AOP - February 14, 2013 Category: Cancer & Oncology Authors: N C TebbuttM M ParryD ZanninoA H StricklandG A Van HazelN PavlakisV GanjuD MellorA DobrovicV J Gebski Source Type: research

The association between physical activity and renal cancer: systematic review and meta-analysis
p; M F Leitzmann
Source: British Journal of Cancer AOP - February 14, 2013 Category: Cancer & Oncology Authors: G BehrensM F Leitzmann Source Type: research

Reply: On the clinical relevance of circulating endothelial cells and platelets in prostate cancer
orcoran & C M Hovens
Source: British Journal of Cancer AOP - February 14, 2013 Category: Cancer & Oncology Authors: C K E WongB NamdarianJ ChuaX ChinR SpeirsT NguyenM FankhauserJ PedersenA J CostelloN M CorcoranC M Hovens Source Type: research

On the clinical relevance of circulating endothelial cells and platelets in prostate cancer
& P Mancuso
Source: British Journal of Cancer AOP - February 14, 2013 Category: Cancer & Oncology Authors: F BertoliniY ShakedP Mancuso Source Type: research

Head and neck cancer cells and xenografts are very sensitive to palytoxin: decrease of c-jun n-terminale kinase-3 expression enhances palytoxin toxicity
Conclusions: These results clearly provide evidence that PTX possesses preferential toxicity for head and neck carcinoma cells and therefore it is worth further studying its impact which may extend our knowledge of the biology of head and neck cancer.
Source: Molecular Cancer - February 14, 2013 Category: Cancer & Oncology Authors: Tibor GöröghLászló BèressElgar QuabiusPetra AmbroschMarkus Hoffmann Source Type: research

Transcription signatures encoded by ultraconserved genomic regions in human prostate cancer
Conclusions: This first study of ucRNA expression in human prostate cancer indicates an altered transcript expression in the disease.
Source: Molecular Cancer - February 14, 2013 Category: Cancer & Oncology Authors: Robert HudsonMing YiNatalia VolfovskyRobyn PrueittDominic EspositoStefano VoliniaChang-Gong LiuAaron SchetterKatrien RoosbroeckRobert StephensGeorge CalinCarlo CroceStefan Ambs Source Type: research

Src-mediated morphology transition of lung cancer cells in three-dimensional organotypic culture
In this study, we utilize a reconstituted basement membrane mimics Matrigel based three-dimensional organotypic culture (rBM 3-D) to investigate the mechanisms that mediate the tumor promoting effects of the fibrogenic mediators TGF-beta1 and type I collagen (Col-1) on lung adenocarcinoma cells. Similar to normal alveolar epithelial cells, the well-differentiated lung adenocarcinoma cells in rBM 3-D culture undergo acinar morphogeneis that features polarized epithelial cell spheres with a single central lumen. Either TGF-beta1 or Col-1 modestly distorts acinar morphogenesis. On the other hand, TGF-beta1 and Col-1 synergist...
Source: Cancer Cell International - February 14, 2013 Category: Cancer & Oncology Authors: Hong NguyenYan ZhuangLichun SunSteven KantrowJay KollsZongbing YouYing ZhuoBin Shan Source Type: research

Conversion to sirolimus in kidney transplant recipients with squamous cell cancer and changes in immune phenotype
Conclusions Conversion to mTORi from CNI may reveal a pre-existing high Treg phenotype by unmasking CNI inhibition of FOXP3 expression. Cessation of AZA leads to increased NK cell number. High FOXP3+ T-cell number on conversion to mTORi may predict those KTRs who continue to accrue SCC.
Source: Nephrology Dialysis Transplantation - February 14, 2013 Category: Transplant Surgery Authors: Carroll, R. P., Hester, J., Wood, K. J., Harden, P. N. Tags: Renal Transplantation Source Type: research

Calprotectin and neutrophil gelatinase–associated lipocalin in the differentiation of pre‐renal and intrinsic acute kidney injury
ConclusionThis study shows that both calprotectin and NGAL are able to differentiate between pre‐renal and intrinsic AKI after exclusion of pyuria. In the present population, calprotectin presents a higher sensitivity and specificity than NGAL.
Source: Acta Physiologica - February 14, 2013 Category: Physiology Authors: F. S. Seibert, N. Pagonas, R. Arndt, F. Heller, D. Dragun, P. Persson, K. Schmidt‐Ott, W. Zidek, T. H. Westhoff Tags: Original Article Source Type: research

Long-term experience on laparoscopic incontinent urinary diversion unrelated to cystectomy in radiated or recurrent pelvic malignancies
Marcos Tobias-Machado, Leonardo S Lopes, Felipe Brandao Correa de Araujo, Eduardo S Starling, Antonio Carlos Lima PompeoJournal of Minimal Access Surgery 2013 9(1):3-6Background: There are few reports describing series of cases about development on laparoscopic urinary diversions no related to cystectomy. The aim of this paper is to show the experience of our reference institutions for treatment of pelvic malignancies when laparoscopic techniques were applied to perform only urinary diversion without cystectomy or pelvic exenteration. Materials and Methods: We included retrospectively 12 cases of cutaneous ureterostomy and...
Source: Journal of Minimal Access Surgery - February 14, 2013 Category: Surgery Authors: Marcos Tobias-MachadoLeonardo S LopesFelipe Brandao Correa de AraujoEduardo S StarlingAntonio Carlos Lima Pompeo Source Type: research

Systematic evaluation of the methodology of randomized controlled trials of anticoagulation in patients with cancer
Conclusions: Many RCTs of anticoagulation in patients with cancer appear to use insufficiently rigorous outcome assessment methods and to have deficiencies in key methodological features. It is not clear whether this reflects a problem in the design, conduct or the reporting of these trials, or both. Future trials should avoid the shortcomings described in this article.
Source: BioMed Central - February 13, 2013 Category: Journals (General) Authors: Gabriel RadaHolger J SchünemannNawman LabediPierre El-HachemVictor KairouzElie A Akl Source Type: research

Sertoliform cystadenoma: a rare benign tumour of the rete testis
We describe a case of a 66-year-old man with a tumour in the area of the epididymal head. The tumour markers were not increased. Under the assumption of a malignant testicular tumour an inguinal orchiectomy was performed. The cut surface of this tumour was of grey/white color and showed small cysts. The tumour consisted of two compartments. The epithelial like tumour cells showed a sertoliform growth pattern and cystic dilatations. In between the tumour cells repeatedly actin expressing sclerotic areas could be recognized as the second tumour component. Proliferative activity was not increased. Immunohistochemically the tu...
Source: BioMed Central - February 13, 2013 Category: Journals (General) Authors: Felix BremmerStefan SchweyerCarl Ludwig BehnesManfred BlechHeinz Joachim Radzun Source Type: research

Epigenetic inactivation of the MIR129-2 in hematological malignancies
Background: MIR129-2 has been shown to be a tumor suppressor microRNA hypermethylated in epithelial cancers.Patients and methods: Epigenetic inactivation of MIR129-2 was studied by methylation-specific PCR (MSP) in 13 cell lines (eight myeloma and five lymphoma), 15 normal controls and 344 primary samples including acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic myeloid leukemia (CML), chronic lymphocytic leukemia (CLL), non-Hodgkin's lymphoma (NHL), multiple myeloma (MM) at diagnosis, MM at relapse/progression, and monoclonal gammopathy of undetermined significance (MGUS). Expression of MIR129 an...
Source: Journal of Hematology and Oncology - February 13, 2013 Category: Hematology Authors: Kwan-Yeung WongRita YimYok-Lam KwongChung-Ying LeungPak-Kwan HuiFlorence CheungRaymond LiangDong-Yan JinChor-Sang Chim Source Type: research

Dose-Intensive Chemotherapy Including Rituximab in Burkitt's Leukemia or Lymphoma Regardless of Human Immunodeficiency Virus Infection Status: Final Results of a Phase 2 Study (Burkimab)
In a phase II study, Spanish authors concluded that dose-intensive chemotherapy with rituximab is effective in both HIV-positive and HIV-negative patients with Burkitt’s lymphoma. Abstract Background:...
Source: OncologySTAT Journal Scans - February 13, 2013 Category: Cancer & Oncology Source Type: research

Serum Antibodies to Blood Group A Predict Survival on PROSTVAC-VF
Prevaccination IgM antibodies to anti-BG-Atr were significantly associated with survival in patients with advanced prostate cancer treated with PROSTVAC-VF. SUMMARY OncologySTAT Editorial Team Therapeutic...
Source: OncologySTAT Journal Scans - February 13, 2013 Category: Cancer & Oncology Source Type: research

Increased risk for cancer among offspring of women with fertility problems
Abstract Some studies have indicated that children born after fertility treatment have a potential risk for cancer, but the results are inconsistent. Furthermore, any negative effects of fertility treatment might be due to the underlying infertility rather than to the procedure itself. In the largest cohort study to date with information on fertility, we examined whether the offspring of women with fertility problems had a higher risk for cancer than offspring of women without fertility problems. The study cohort consisted of 2 830 054 offspring born in Denmark between 1964 and 2006. Of these, 125 844 were offspring of wom...
Source: International Journal of Cancer - February 13, 2013 Category: Cancer & Oncology Authors: Marie Hargreave, Allan Jensen, Isabelle Deltour, Louise A. Brinton, Klaus K. Andersen, Susanne K. Kjaer Tags: Epidemiology Source Type: research

A phase 1 study of everolimus plus docetaxel plus cisplatin as induction chemotherapy for patients with locally and/or regionally advanced head and neck cancer
CONCLUSIONS:The phase 2 recommended dose was 7.5 mg daily for everolimus plus cisplatin and docetaxel (both at 75 mg/m2 on day 1 of a 21‐day cycle) given with pegfilgrastim support. Cancer 2013;. © 2013 American Cancer Society.
Source: Cancer - February 13, 2013 Category: Cancer & Oncology Authors: Matthew G. Fury, Eric Sherman, Alan L. Ho, Han Xiao, Frank Tsai, Oby Nwankwo, Camelia Sima, Adrian Heguy, Nora Katabi, Sofia Haque, David G. Pfister Tags: Original Article Source Type: research

Xist RNA Is a Potent Suppressor of Hematologic Cancer in Mice
Eda Yildirim, James E. Kirby, Diane E. Brown, Francois E. Mercier, Ruslan I. Sadreyev, David T. Scadden, Jeannie T. Lee. X chromosome aneuploidies have long been associated with human cancers, but causality has not been established. In mammals, X chromosome inactivation (XCI) is triggered by Xist RNA to equalize gen....
Source: Cell - February 13, 2013 Category: Cytology Source Type: research

Evolution and Impact of Subclonal Mutations in Chronic Lymphocytic Leukemia
Dan A. Landau, Scott L. Carter, Petar Stojanov, Aaron McKenna, Kristen Stevenson, Michael S. Lawrence, Carrie Sougnez, Chip Stewart, Andrey Sivachenko, Lili Wang, Youzhong Wan, Wandi Zhang, Sachet A. Shukla, Alexander Vartanov, Stacey M. Fernandes, Gordon Saksena, Kristian Cibulskis, Bethany Tesar, Stacey Gabriel, Nir Hacohen, Matthew Meyerson, Eric S. Lander, Donna Neuberg, Jennifer R. Brown, Gad Getz, Catherine J. Wu. Clonal evolution is a key feature of cancer progression and relapse. We studied intratumoral heterogeneity in 149 chronic lymphocytic leukemia (CLL) cases by integrating whole-exome sequence and c....
Source: Cell - February 13, 2013 Category: Cytology Source Type: research

PGC1α Expression Defines a Subset of Human Melanoma Tumors with Increased Mitochondrial Capacity and Resistance to Oxidative Stress
Francisca Vazquez, Ji-Hong Lim, Helen Chim, Kavita Bhalla, Geoff Girnun, Kerry Pierce, Clary B. Clish, Scott R. Granter, Hans R. Widlund, Bruce M. Spiegelman, Pere Puigserver. Cancer cells reprogram their metabolism using different strategies to meet energy and anabolic demands to maintain growth and survival. Understanding the molecular and genetic determinants of thes....
Source: Cancer Cell - February 13, 2013 Category: Cancer & Oncology Source Type: research

Texas Senate passes CPRIT reform bill
A Texas Senate committee has passed a new measure that reforms the Cancer Prevention and Research Institute of Texas (CPRIT). CPRIT was formed after Texas voters approved a constitutional amendment in 2007 authorizing the sale of $3 billion in bonds to furnish money for cancer research and treatment. Since December, the organization has been under fire for its internal review processes regarding the approval of grants. CPRIT Executive Director Bill Gimson resigned from the organization amid the…
Source: bizjournals.com Health Care:Physician Practices headlines - February 13, 2013 Category: American Health Authors: James Aldridge Source Type: research

Effect of Screening Mammography on Breast Cancer Incidence
New England Journal of Medicine, Volume 368, Issue 7, Page 677-679, February 2013.
Source: New England Journal of Medicine - February 13, 2013 Category: Internal Medicine Tags: article Source Type: research

Selumetinib-Enhanced Radioiodine Uptake in Advanced Thyroid Cancer
New England Journal of Medicine, Volume 368, Issue 7, Page 623-632, February 2013.
Source: New England Journal of Medicine - February 13, 2013 Category: Internal Medicine Tags: article Source Type: research

Well-Being after Radiation Therapy in Thyroid Cancer
New England Journal of Medicine, Volume 368, Issue 7, Page 685-686, February 2013.
Source: New England Journal of Medicine - February 13, 2013 Category: Internal Medicine Tags: article Source Type: research

BRAF V600E Inhibition in Anaplastic Thyroid Cancer
New England Journal of Medicine, Volume 368, Issue 7, Page 684-685, February 2013.
Source: New England Journal of Medicine - February 13, 2013 Category: Internal Medicine Tags: article Source Type: research

Cervical Cancer Screening Preferences among African American Women in the Mississippi Delta.
This study examined women's preferences for cervical cancer screening methods. Interviewer-administered questionnaires regarding cervical cancer screening preferences were completed by 524 African American women in the Mississippi Delta. Statistically significant differences were observed for age, employment status, and number of children across recruitment groups. Regardless of how women were recruited, the majority preferred self-sampling for HPV testing method to clinician-collection. Among women who preferred self-collected sampling for HPV testing, the most frequent reasons given were convenience, pr...
Source: Journal of Health Care for the Poor and Underserved - February 13, 2013 Category: Global & Universal Authors: Litton AG, Castle PE, Partridge EE, Scarinci IC Tags: J Health Care Poor Underserved Source Type: research

Health Beliefs, Attitudes and Service Utilization among Haitians.
Abstract Abstract:Understanding the factors that influence health beliefs, attitudes, and service use among Haitians in the United States is increasingly important for this growing population. We undertook a qualitative analysis to explore the factors related to cancer screening and utilization of health services among Haitians in Boston. Key informant interviews (n=42) and nine focus groups (n=78) revealed that Haitians experience unique barriers to health services. These include language barriers, unfamiliarity with preventive care, confidentiality concerns, mistrust and stigma concerning Western ...
Source: Journal of Health Care for the Poor and Underserved - February 13, 2013 Category: Global & Universal Authors: Allen JD, Mars DR, Tom L, Apollon G, Hilaire D, Iralien G, Cloutier LB, Sheets MM, Zamor R Tags: J Health Care Poor Underserved Source Type: research

A Tailored Prostate Cancer Education Intervention for Low-income African Americans: Impact on Knowledge and Screening.
Abstract Abstract:African American men bear disproportionate burden of prostate cancer (PCa) that can be reduced by early detection. A 15-minute culturally appropriate PCa education intervention developed to communicate effective, relevant, and balanced PCa screening information to low-income African American men was evaluated in men 42 years and older who had not been screened in one year. Of 539 men enrolled, 392 (72.7%) completed the six-month follow-up. Mean age was 54.4±8.9, 34.7% had no high school diploma, and 65.3% earned less than $25,000 annually. Barriers to screening included health ins...
Source: Journal of Health Care for the Poor and Underserved - February 13, 2013 Category: Global & Universal Authors: Ukoli FA, Patel K, Hargreaves M, Beard K, Moton PJ, Bragg R, Beech D, Davis R Tags: J Health Care Poor Underserved Source Type: research

Preoperative detection and predictors of level V lymph node metastasis in patients with papillary thyroid carcinoma (Br J Surg 2013; 100: 497-503).
PMID: 23378202 [PubMed - in process]
Source: The British Journal of Surgery - February 13, 2013 Category: Surgery Authors: Kirkby-Bott J Tags: Br J Surg Source Type: research

Detection of carbohydrates on the surface of cancer and normal cells by topography and recognition imaging
Chem. Commun., 2013, Advance ArticleDOI: 10.1039/C3CC38885A, CommunicationWeidong Zhao, Shuheng Liu, Mingjun Cai, Haijiao Xu, Junguang Jiang, Hongda WangWith PHA-L functionalized tips, galactoses were localized on the surface of cancer and normal cells by topography and recognition imaging.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - February 13, 2013 Category: Chemistry Authors: Weidong Zhao Source Type: research

Early experience with laparoscopic lavage for perforated diverticulitis
ConclusionLaparoscopic lavage for perforated diverticulitis was feasible in the majority of patients, but identification of an overt sigmoid perforation and patient selection are of critical importance. © 2013 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Source: British Journal of Surgery - February 13, 2013 Category: Surgery Authors: H. A. Swank, I. M. Mulder, A. G. M. Hoofwijk, S. W. Nienhuijs, J. F. Lange, W. A. Bemelman, Tags: Original Article Source Type: research

The TNFRs OX40, 4-1BB, and CD40 as targets for cancer immunotherapy.
Abstract T cell-mediated rejection of tumors requires signals from the T cell receptor and co-stimulatory molecules to license effector functions of tumor-antigen specific T cells. There is also an array of immune suppressive mechanisms within the tumor microenvironment that can suppress anti-tumor immunity. The use of monoclonal antibodies to overcome this suppression and/or enhance tumor-antigen specific T cell responses has shown promise in clinical trials. In particular, targeting co-stimulatory members of the tumor necrosis factor receptor (TNFR) family with agonist Abs enhances T cell function, which has led ...
Source: Current Opinion in Immunology - February 13, 2013 Category: Allergy & Immunology Authors: Moran AE, Kovacsovics-Bankowski M, Weinberg AD Tags: Curr Opin Immunol Source Type: research

BH3 Mimetics Reduce Adhesion and Migration of Hepatoblastoma and Hepatocellular Carcinoma Cells.
Abstract Advanced stages of tumour and development of metastases are the two major problems in treating liver tumours such as hepatoblastoma (HB) and hepatocellular carcinoma (HCC), in paediatric patients. Modulation of apoptosis in HB cells enhances the sensitivity of these cells towards various drugs and has been discussed to enforce treatment. We analysed the effect of apoptosis modulators, BH3 mimetics, on mechanisms of dissemination such as adhesion or migration of HB and HCC cells. BH3 mimetics such as ABT-737 and obatoclax can reduce cell migration in a scratch assay as well as adhesion of HB and HCC cells t...
Source: Experimental Cell Research - February 13, 2013 Category: Cytology Authors: Vogt F, Lieber J, Dewerth A, Hoh A, Fuchs J, Armeanu-Ebinger S Tags: Exp Cell Res Source Type: research

REST: an oncogene or a tumor suppressor?
Abstract The Repressor Element-1 (RE-1) Silencing Transcription (REST) factor, which is highly expressed in stem cells and non-neural cells, with low expression in neurons and other neural cells, orchestrates neural differentiation and preserves the unique neural phenotype. REST also plays a role in proliferation, although its effect differs depending on the cell type. It acts as an oncogene in neural cells and tumors (medulloblastomas, neuroblastomas, glioblastomas) and as a tumor suppressor in carcinomas of the lung, breast, and colon. The mechanisms underlying this duality have started to emerge recently and new...
Source: Trends in Cell Biology - February 13, 2013 Category: Cytology Authors: Negrini S, Prada I, D'Alessandro R, Meldolesi J Tags: Trends Cell Biol Source Type: research

The expression and clinical significance of microRNA-1258 and heparanase in human breast cancer.
CONCLUSIONS: MiR-1258 may play an important role in breast cancer development and progression by regulating the expression of HPSE, and they might be potential prognostic biomarkers for breast cancer. PMID: 23415719 [PubMed - as supplied by publisher]
Source: Clinical Biochemistry - February 13, 2013 Category: Biochemistry Authors: Tang D, Zhang Q, Zhao S, Wang J, Lu K, Song Y, Zhao L, Kang X, Wang J, Xu S, Tian L Tags: Clin Biochem Source Type: research

Tousled-like Kinases Modulate Reactivation of Gammaherpesviruses from Latency.
Abstract Kaposi's sarcoma-associated herpesvirus (KSHV) is linked to human malignancies. The majority of tumor cells harbor latent virus, and a small percentage undergo spontaneous lytic replication. Both latency and lytic replication are important for viral pathogenesis and spread, but the cellular players involved in the switch between the two viral life-cycle phases are not clearly understood. We conducted a small interfering RNA (siRNA) screen targeting the cellular kinome and identified Tousled-like kinases (TLKs) as cellular kinases that control KSHV reactivation from latency. Upon treatment of latent KSHV-i...
Source: Cell Host and Microbe - February 13, 2013 Category: Microbiology Authors: Dillon PJ, Gregory SM, Tamburro K, Sanders MK, Johnson GL, Raab-Traub N, Dittmer DP, Damania B Tags: Cell Host Microbe Source Type: research

Targeting the Akt kinase to modulate survival, invasiveness and drug resistance of cancer cells.
Abstract The deregulation of oncogenic signaling pathways which provide survival advantages to tumor cells is mediated by multiple cellular networks. Among them, the PI3K-Akt-mTOR axis, in particular the serine/threonine kinase Akt, is recognized as a key player. The kinase is hyperactivated due to a variety of mechanism including loss of PTEN, mutations in the PI3K catalytic subunit, receptor tyrosine kinase and Ras activation. Indeed, inappropriate activation of the Akt kinase is a common event in human tumors and Akt appears to be a critical player in cell survival that may also account for the therapeutic resis...
Source: Current Medicinal Chemistry - February 13, 2013 Category: Chemistry Authors: Cassinelli G, Zuco V, Gatti L, Lanzi C, Zaffaroni N, Colombo D, Perego P Tags: Curr Med Chem Source Type: research

Hepatic Leukemia Factor Promotes Resistance To Cell Death: Implications For Therapeutics and Chronotherapy.
Abstract Physiological variation related to circadian rhythms and aberrant gene expression patterns are believed to modulate therapeutic efficacy, but the precise molecular determinants remain unclear. Here we examine the regulation of cell death by hepatic leukemia factor (HLF), which is an output regulator of circadian rhythms and is aberrantly expressed in human cancers, using an ectopic expression strategy in JB6 mouse epidermal cells and human keratinocytes. Ectopic HLF expression inhibited cell death in both JB6 cells and human keratinocytes, as induced by serum-starvation, tumor necrosis factor alpha and ion...
Source: Toxicology and Applied Pharmacology - February 13, 2013 Category: Toxicology Authors: Waters KM, Sontag RL, Weber TJ Tags: Toxicol Appl Pharmacol Source Type: research

Alleviating Anastrozole induced bone toxicity by selenium nanoparticles in SD Rats.
Abstract Aromatase inhibitors like anastrozole play an undisputed key role in the treatment of breast cancer, but on the other hand, various side effects like osteoporosis and increased risk of bone fracture accompanies the chronic administration of these drugs. Here we show for the first time that selenium nanoparticles, when given in conjugation to anastrozole, lower the bone toxicity caused by anastrozole and thus reduces the probable damage to the bone. Selenium nanoparticles at a dose of 5μg/ml significantly reduced the cell death caused by anastrozole (1μM) in HOS (human osteoblast) cells. In addition, our ...
Source: Toxicology and Applied Pharmacology - February 13, 2013 Category: Toxicology Authors: Vekariya KK, Kaur J, Tikoo K Tags: Toxicol Appl Pharmacol Source Type: research

Mesothelial cell: A multifaceted model of aging.
Abstract Human peritoneal mesothelial cells (HPMCs) dominate within the peritoneal cavity and thus play a central role in a variety of intraperitoneal processes, including the transport of water and solutes, inflammation, host response, angiogenesis, and extracellular matrix remodeling. In addition, they contribute to the development of abdominal adhesions, peritonitis, endometriosis, cancer cell metastases, and peritoneal dialysis complications. For less than a decade the primary cultures of omental HPMCs have also been used as an experimental tool in studies on cellular aging. This paper provides the first compre...
Source: Ageing Research Reviews - February 13, 2013 Category: Genetics & Stem Cells Authors: Książek K Tags: Ageing Res Rev Source Type: research

Multifocality rather than tumor location is a prognostic factor in upper tract urothelial carcinoma.
CONCLUSIONS: Tumor location does not appear to have any influence on the risk of recurrence of disease following nephroureterectomy in this large patient cohort. However, multifocal tumors involving both the ureter and renal pelvis had a significantly worse prognosis and should be considered for more aggressive management. PMID: 23415596 [PubMed - as supplied by publisher]
Source: Urologic Oncology - February 13, 2013 Category: Urology & Nephrology Authors: Williams AK, Kassouf W, Chin J, Rendon R, Jacobsen N, Fairey A, Kapoor A, Black P, Lacombe L, Tanguay S, So A, Lattouf JB, Bell D, Fradet Y, Saad F, Matsumoto E, Drachenberg D, Cagiannos I, Izawa JI Tags: Urol Oncol Source Type: research

[Laparoscopic vs open surgery in colorectal cancer : The 10-year results of the CLASICC trial.]
[Laparoscopic vs open surgery in colorectal cancer : The 10-year results of the CLASICC trial.] Chirurg. 2013 Feb 13; Authors: Reibetanz J, Germer CT PMID: 23400763 [PubMed - as supplied by publisher]
Source: Der Chirurg - February 13, 2013 Category: Surgery Authors: Reibetanz J, Germer CT Tags: Chirurg Source Type: research

Improved follow-up of patients with differentiated thyroid carcinoma. The quantitative detection limit of 131I uptake in diagnostic scans.
Conclusion: LoD data obtained by the proposed method closely reflect nuclear medicine specialists' scan ratings and provide comparators in serial scintigrams, improving diagnostic 131I imaging accuracy in differentiated thyroid carcinoma. PMID: 23403717 [PubMed - as supplied by publisher]
Source: Nuklearmedizin - February 13, 2013 Category: Radiology Authors: Dießl S, Verburg F, Biko J, Schryen B, Reiners C, Buck A, Hänscheid H Tags: Nuklearmedizin Source Type: research

BLM and RAD51 Genes Polymorphism and Susceptibility to Breast Cancer.
Abstract DNA repair by homologous recombination is one of the main processes of DNA double strand breaks repair. In the present work we performed a case-control study (304 cases and 319 controls) to check an association between the genotypes of the c.-61 G>T and the g.38922 C>G polymorphisms of the RAD51 gene and the g.96267 A>C and the g.85394 A>G polymorphisms of the BLM gene and breast cancer occurrence. Genotypes were determined in DNA from peripheral blood by PCR-RLFP and by PCR-CTPP. We observed an association between breast cancer occurrence and the T/G genotype (OR 4.41) of the c.-61 G>T-RAD5...
Source: Pathology Oncology Research - February 13, 2013 Category: Pathology Authors: Sassi A, Popielarski M, Synowiec E, Morawiec Z, Wozniak K Tags: Pathol Oncol Res Source Type: research

The Association Between Self-Reported Diabetes and Cancer Incidence in the NIH-AARP Diet and Health Study.
Conclusion:Our results suggest an etiological role for diabetes in a number of cancers, independent of obesity, and that preventing diabetes may contribute to reduced cancer risk. PMID: 23408570 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - February 13, 2013 Category: Endocrinology Authors: Lai GY, Park Y, Hartge P, Hollenbeck AR, Freedman ND Tags: J Clin Endocrinol Metab Source Type: research

Associations Between Body Size and Serum Estradiol and Sex Hormone-Binding Globulin Levels in Premenopausal African American Women.
Conclusions:Premenopausal AA women with higher WHR or larger WC may have higher levels of estradiol and lower levels of SHBG. Thus, WHR or WC may be better indicators for assessing hormonal patterns implicated in breast cancer pathogenesis in these women. PMID: 23408572 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - February 13, 2013 Category: Endocrinology Authors: Paxton RJ, King DW, Garcia-Prieto C, Connors SK, Hernandez M, Gor BJ, Jones LA Tags: J Clin Endocrinol Metab Source Type: research

CA-125¿indicated asymptomatic relapse confers survival benefit to ovarian cancer patients who underwent secondary cytoreduction surgery
Background: There is no consensus regarding the management of ovarian cancer patients, who have shown complete clinical response (CCR) to primary therapy and have rising cancer antigen CA-125 levels but have no symptoms of recurrent disease. The present study aims to determine whether follow-up CA-125 levels can be used to identify the need for imaging studies and secondary cytoreductive surgery (CRS). Methods: We identified 410 ovarian cancer patients treated at The University of Texas MD Anderson Cancer Center between 1984 and 2011. These patients had shown CCR to primary therapy. Follow-up was conducted based on the sur...
Source: Journal of Ovarian Research - February 13, 2013 Category: Cancer & Oncology Authors: Fang WangYanfen YeXia XuXuehui ZhouJinhua WangXiaoxiang Chen Source Type: research

Recent Advances Using Immunomodulators for Inflammatory Bowel Disease.
Abstract Use of the immunomodulators thiopurines and methotrexate (MTX) in the treatment of inflammatory bowel disease (IBD), i.e., Crohn's disease and ulcerative colitis (UC), is considered to be good clinical practice. However, despite being administered to a considerable number of IBD patients over the years, questions remain about the most rational treatment regimens of azathioprine (AZA), 6-mercaptopurine (6-MP), and MTX, and results from a range of recent studies necessitate increased attention to how to optimize the use of these immunomodulators. First and foremost, it is of utmost importance to define the s...
Source: The Journal of Clinical Pharmacology - February 13, 2013 Category: Drugs & Pharmacology Authors: Nielsen OH, Bjerrum JT, Herfarth H, Rogler G Tags: J Clin Pharmacol Source Type: research

Efficacy of everolimus with exemestane versus exemestane alone in Asian patients with HER2-negative, hormone-receptor-positive breast cancer in BOLERO-2.
CONCLUSION: Adding EVE to EXE provided substantial clinical benefit in both Asian and non-Asian patients with similar safety profiles. This combination represents an improvement in the management of postmenopausal women with HR(+)/HER2(-) advanced breast cancer progressing on nonsteroidal aromatase inhibitors, regardless of ethnicity. PMID: 23404211 [PubMed - as supplied by publisher]
Source: Breast Cancer - February 13, 2013 Category: Cancer & Oncology Authors: Noguchi S, Masuda N, Iwata H, Mukai H, Horiguchi J, Puttawibul P, Srimuninnimit V, Tokuda Y, Kuroi K, Iwase H, Inaji H, Ohsumi S, Noh WC, Nakayama T, Ohno S, Rai Y, Park BW, Panneerselvam A, El-Hashimy M, Taran T, Sahmoud T, Ito Y Tags: Breast Cancer Source Type: research