Cancer & Oncology 
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This page shows you the most recent publications within this specialty of the MedWorm directory.
Association of Mutation and Methylation in the Promoter Region of TIF1γ
with Non-small Cell Lung Cancer
Background and objective TIF1γ (transcription intermediary factor 1 gamma), which belongs to transcription intermediary factor 1 family, is an inhibitor of the TGF-β/Smad signaling pathway and could inhibit the signal transduction mediated by TGF-β. The deficiency of TIF1γ expression in a variety of tumor cells suggests that TIF1γ may play as a tumor suppressor gene in cancer development. The aim of this study is to confirm the relationship between TIF1γ and non-small cell lung cancer (NSCLC) through exploring the expression of TIF1γ in NSCLC cells and tissues, and investigate the regulation mechanism of TIF1γ expr...
Source: Chinese Journal of Lung Cancer - May 19, 2013 Category: Cancer & Oncology Source Type: research
Preliminary Study of MALDI-TOF Mass Spectrometry-based Screening of Patients with the NSCLC Serum-Specific Peptides
Background and objective The improved survival of patients with lung cancer depends on early diagnosis of lung cancer. However, the traditional diagnostic techniques have several limitations. Mass spectrometry (MS) has been applied as a core technology for cancer diagnosis in preliminary proteomic studies. The aim of this study is to explore the differences in the serum peptide levels of patients with non-small cell lung cancer (NSCLC) and healthy individuals using matrix-assisted laser desorption/ionization (MALDI)-time-of-flight (TOF)-MS. A NSCLC serum classification model was then established. Methods One hundred and th...
Source: Chinese Journal of Lung Cancer - May 19, 2013 Category: Cancer & Oncology Source Type: research
Clinical Effects for Patients with Recurrent Advanced Non-small Cell Lung Cancer Treated with Icotinib Hydrochloride
Background and objective Icotinib hydrochloride is the third single target EGFR-TKI used in clinical treatment of advanced non-small cell lung cancer (NSCLC). Clinical research reports on its efficacy and survival in patients with Recurrent Advanced NSCLC are still little.The aim of this study is to evaluate the efficacy and survival of Icotinib hydrochloride for patients with advanced non-small cell lung cancer who failed to previous chemotherapy and explore the association of clinical features with the efficacy and survival. Methods The clinical data of 60 NSCLC patients referred to the Beijing Chest Hospital, Capital Me...
Source: Chinese Journal of Lung Cancer - May 19, 2013 Category: Cancer & Oncology Source Type: research
Pathological Characteristic and Clinical Management of Pulmonary Carcinoid
Conclusion Pathological diagnosis of pulmonary carcinoid must combine morphology with immunohistochemistry. Early-stage patients can also achieve good effect after surgery. DOI: 10.3779/j.issn.1009-3419.2013.05.06 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - May 19, 2013 Category: Cancer & Oncology Source Type: research
Dosimetric Comparing between Protons Beam and Photons Beam
for Lung Cancer Radiotherapy: A Meta-analysis
Background and objective The clinical evidences are not sufficient on the proton beam therapy of lung cancer for lacking of the RCTs on the comparing the proton with the photon beam in lung cancer radiotherapy. The aim of this study is to evaluate the dosimetry superiority of the proton beam and provide more valuable evidences to the clinical researches. Methods Clinical trails of dosimetric comparing between protons beam and photons beam for lung cancer radiotherapy were obtained from the Cochrane library, Pubmed, EMbase, CBM, CNKI, VIP, and Wan Fang databases. The data included in the study were evaluated and analyzed us...
Source: Chinese Journal of Lung Cancer - May 19, 2013 Category: Cancer & Oncology Source Type: research
Research Progress of Treatment Strategy for Pulmonary Nodule
DOI: 10.3779/j.issn.1009-3419.2013.05.08 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - May 19, 2013 Category: Cancer & Oncology Source Type: research
Interstitial Lung Disease Associated with Lung Cancer Treatment
Interstitial lung disease is one of the most serious side effects caused by lung cancer treatment. Due to the complexity diagnosis and variability of the disease, it is often not diagnosied and treated in time, even endanger the patient's life and affect the patient's prognosis. The mechanism of interstitial pneumonia caused by radiotherapy, chemotherapy and targeted therapy is still not fully known. Therefore, it become a problem that how to early detection, diagnosis and treat the interstitial lung disease caused by lung cancer treatment and it should not be ignored in the future. DOI: 10.3779/j.issn.1009-3419.2013.05.09...
Source: Chinese Journal of Lung Cancer - May 19, 2013 Category: Cancer & Oncology Source Type: research
Giant Primitive Nuroectodermal Tumor of Mediastinum:
A Case Report with Literature Review
DOI: 10.3779/j.issn.1009-3419.2013.05.10 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - May 19, 2013 Category: Cancer & Oncology Source Type: research
Using microRNA profiling in urine samples to develop a non‐invasive test for bladder cancer
This study aimed to examine the microRNA (miRNA) expression profiles in urines of UCC patients in order to develop a non‐invasive accurate and reliable tool to diagnose and provide information on the aggressiveness of the tumour. We performed a global miRNA expression profiling analysis of the urinary cells from 40 UCC patients and controls using TaqMan® Human MicroRNA Array followed by validation of 22 selected potentially diagnostic and prognostic miRNAs in a separate cohort of 277 samples using a miRCURY LNATM qPCR system. miRNA‐based signatures were developed by multivariate logistic regression analysis and intern...
Source: International Journal of Cancer - May 19, 2013 Category: Cancer & Oncology Authors: Lourdes Mengual, Juan José Lozano, Mercedes Ingelmo‐Torres, Cristina Gazquez, María José Ribal, Antonio Alcaraz Tags: Early Detection and Diagnosis Source Type: research
Abstract
(Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - May 19, 2013 Category: Cancer & Oncology Tags: Abstract Source Type: research
New AUA Guidelines for Prostate Cancer Screening
The American Urological Association (AUA) released a new clinical guideline detailing recommendations for the use of prostate cancer screening in average-risk men based upon evidence from a systematic literature review. The guideline, which was announced during the 2013 AUA Annual Meeting, recommends that men aged 55 to 69 years who are considering undergoing prostate cancer screening should talk with their physicians about the benefits and risks of screening. (Source: Cancer Network)
Source: Cancer Network - May 19, 2013 Category: Cancer & Oncology Source Type: news
Ultrasound Probe and Needle-Guide Calibration for Robotic Ultrasound Scanning and Needle Targeting
We report a calibration method for 2-D ultrasound probes using robotic manipulation and a planar calibration rig. Moreover, a needle guide that is attached to the probe is also calibrated for ultrasound-guided needle targeting. The method is applied to a transrectal ultrasound (TRUS) probe for robot-assisted prostate biopsy. Validation experiments include TRUS-guided needle targeting accuracy tests. This paper outlines the entire process from the calibration to image-guided targeting. Freehand TRUS-guided prostate biopsy is the primary method of diagnosing prostate cancer, with over 1.2 million procedures performed annuall...
Source: IEEE Transactions on Biomedical Engineering - May 18, 2013 Category: Biomedical Engineering Source Type: research
Debye Parameter Extraction for Characterizing Interaction of Terahertz Radiation With Human Skin Tissue
This paper is concerned with parameter extraction for the double Debye model, which is used for analytically determining human skin permittivity. These parameters are thought to be the origin of contrast in terahertz (THz) images of skin cancer. The existing extraction methods could generate Debye models, which track their measurements accurately at frequencies higher than 1 THz but poorly at lower frequencies, where the majority of permittivity contrast between healthy and diseased skin tissues is actually observed. We propose a global optimization-based parameter extraction, which results in globally accurate tracking an...
Source: IEEE Transactions on Biomedical Engineering - May 18, 2013 Category: Biomedical Engineering Source Type: research
THE GooseMan: A simulator for transhiatal esophagectomy
Esophageal cancer is the fastest growing cancer in the United States and the seventh leading cause of cancer-related death worldwide. The gold standard therapy is surgical resection commonly performed as a transhiatal esophagectomy (THE), which involves blindly dissecting the esophagus in the mediastinum through abdominal and cervical neck incisions. Compared with transthoracic esophagectomy, which requires creating a direct thoracic incision, THE has similar long-term survival but is less invasive and has fewer complications, a shorter recovery time, and decreased in-hospital mortality. Yet, morbidity and mortality from T...
Source: The Journal of Thoracic and Cardiovascular Surgery - May 18, 2013 Category: Cardiovascular & Thoracic Surgery Authors: Kanika Trehan, Xun Zhou, Yufei Tang, Doru Petrisor, Clinton D. Kemp, Stephen C. Yang Tags: Cardiothoracic Surgical Education and Training Source Type: research
Study Finds Broad Support For Rationing Of Some Types Of Cancer Care
The majority of cancer doctors, patients, and members of the general public support cutting health care costs by refusing to pay for drugs that don't improve survival or quality of life, according to results of a new study that will be presented by researchers from the Perelman School of Medicine at the University of Pennsylvania during the annual meeting of the American Society of Clinical Oncology in Chicago in early June (Abstract #6518)... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 18, 2013 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news
Among Patients Carrying BRCA Mutations, PARP Inhibitor Shows Activity In Pancreatic, Prostate Cancers
In the largest clinical trial to date to examine the efficacy of PARP inhibitor therapy in BRCA 1/2 carriers with diseases other than breast and ovarian cancer, the oral drug olaparib was found to be effective against advanced pancreatic and prostate cancers. Results of the study, led by researchers from the Perelman School of Medicine at the University of Pennsylvania and Sheba Medical Center in Tel Hashomer, Israel, will be presented during the American Society of Clinical Oncology's annual meeting in Chicago in early June (Abstract #11024)... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - May 18, 2013 Category: Consumer Health News Tags: Pancreatic Cancer Source Type: news
New gut microbiome research to explore red meat -- colorectal cancer pathway
(American Gastroenterological Association) The AGA Research Foundation announced a new grant that intends to stimulate research into the relationship between the gut microbiota, one of today's most exciting areas of science, and digestive health and disease. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - May 18, 2013 Category: Global & Universal Source Type: news
Novel mouse model for Gardner syndrome generated by a large‐scale N‐ethyl‐N‐nitrosourea mutagenesis program
Mutant mouse models are indispensable tools for clarifying the functions of genes and elucidating the underlying pathogenic mechanisms of human diseases. We carried out large‐scale mutagenesis using the chemical mutagen N‐ethyl‐N‐nitrosourea. One specific aim of our mutagenesis project was to generate novel cancer models. We screened 7012 animals for dominant traits using a necropsy test and thereby established 17 mutant lines predisposed to cancer. Here, we report on a novel cancer model line that developed osteoma, trichogenic tumor, and breast cancer. Using fine mapping and genomic sequencing, we identified a po...
Source: Cancer Science - May 18, 2013 Category: Cancer & Oncology Authors: Hideaki Toki, Maki Inoue, Hiromi Motegi, Osamu Minowa, Hiroaki Kanda, Noriko Yamamoto, Ami Ikeda, Yuko Karashima, Junko Matsui, Hideki Kaneda, Ikuo Miura, Tomohiro Suzuki, Shigeharu Wakana, Hiroshi Masuya, Yoichi Gondo, Toshihiko Shiroishi, Tetsu Akiyama, Tags: Original Article Source Type: research
New Device May Show Doctors More of the Colon
Advanced colonoscope has wider range of view than traditional models, picks up more polyps, study finds (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - May 18, 2013 Category: Cancer & Oncology Authors: webmaster at doctorslounge.com Tags: Oncology, Research, News, Source Type: news
Prophylactic Mastectomy
A prophylactic mastectomy may be done to reduce the risk of breast cancer. A prophylactic mastectomy may also be called a preventive mastectomy. Learn the definition of a prophylactic mastectomy here. (Source: About.com Breast Cancer)
Source: About.com Breast Cancer - May 18, 2013 Category: Cancer & Oncology Authors: breastcancer.guide at about.com Tags: health Source Type: news
Can I Inherit Colon Cancer?
Although you cannot inherit colon cancer, you can inherit specific gene mutations that greatly increase your risk for the disease. Learn more about these familial gene mutations, genetic testing, and colon cancer screening recommendations. (Source: About.com Colon Cancer)
Source: About.com Colon Cancer - May 18, 2013 Category: Cancer & Oncology Authors: coloncancer.guide at about.com Tags: health Source Type: news
Recovering Following Bowel Sur
Bowel surgery for colon cancer will have physical and emotional impacts. Learn more about what to expect following surgery and how to help your body heal and recover. (Source: About.com Colon Cancer)
Source: About.com Colon Cancer - May 18, 2013 Category: Cancer & Oncology Authors: coloncancer.guide at about.com Tags: health Source Type: news
Diet and Lung Cancer Preventio
Can diet play a role in helping to prevent lung cancer? (Source: About.com Lung Cancer)
Source: About.com Lung Cancer - May 18, 2013 Category: Cancer & Oncology Tags: health Source Type: news
Angelina Jolie Will Have Ovaries Removed to Lower Chances of Cancer: Report
Actress has already had double mastectomy due to gene linked to high risk for breast, ovarian cancer (Source: Cancercompass News: Breast Cancer)
Source: Cancercompass News: Breast Cancer - May 17, 2013 Category: Cancer & Oncology Source Type: news
New Device May Show Doctors More of the Colon
Advanced colonoscope has wider range of view than traditional models, picks up more polyps, study finds (Source: Cancercompass News: Colorectal Cancer)
Source: Cancercompass News: Colorectal Cancer - May 17, 2013 Category: Cancer & Oncology Source Type: news
With same genetic test results 1-in-2 women would follow Jolie
PALO ALTO, Calif., May 17 (UPI) -- One-in-2 U.S. women say if genetic tests suggested a high risk of breast cancer they would follow Angelina Jolie and get a double mastectomy, a survey says. (Source: Health News - UPI.com)
Source: Health News - UPI.com - May 17, 2013 Category: Consumer Health News Source Type: news
Breast cancer: What is the risk?
How high is the risk for the average woman? (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - May 17, 2013 Category: Consumer Health News Source Type: news
M.D. Anderson saw $330M increase in operating expenses
Though the president of The University of Texas M.D. Anderson Cancer Center told employees this week the institution would make budget cuts in several areas, The University of Texas health care system's 2012 annual report foreshadowed the moves.
The report, released in December, shows the cancer center's total operating revenue from August 2011 to August 2012 increased to $3.39 billion, compared to $3.16 billion a year earlier.
But a sharp increased in total operating expenses to $278 million left… (Source: bizjournals.com Health Care:Hospitals headlines)
Source: bizjournals.com Health Care:Hospitals headlines - May 17, 2013 Category: Hospital Management Authors: Bayan Raji Source Type: research
Angelina Jolie’s Double Mastectomy: Q&A
WebMD Medical News
By Kathleen Doheny
Reviewed by Michael W. Smith, MD
May 14, 2013 — Actress and activist Angelina Jolie’s recent decision to have a preventive double mastectomy highlights the difficult choices facing women who find out they have a high risk for breast cancer because of their genes.
Although relatively rare, mutations in the BRCA1 and BRCA2 genes raise the risk of breast cancer by as much as 80%, experts say. The mutations also raise the risk of ovarian cancer.
Jolie describes in a New York Times op-ed piece why she decided to go through with the surgery. At 37, the mother of six wants to sta...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - May 17, 2013 Category: Consumer Health News Authors: mreal197 Tags: WebMD News Source Type: news
Did Angelina Jolie Do the Right Thing?
I was stunned to hear that Angelina Jolie had a double mastectomy to prevent breast cancer. What do you think of her choice? Are there any other options for women who have one of these bad genes? (Source: Dr. Weil Q and A)
Source: Dr. Weil Q and A - May 17, 2013 Category: Consumer Health Advice Source Type: news
HIV No Barrier to Getting Liver Transplant, Study Finds
Procedure recommended to treat aggressive liver cancer (Source: WebMD Health)
Source: WebMD Health - May 17, 2013 Category: Consumer Health News Source Type: news
