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This page shows you the most recent publications within this specialty of the MedWorm directory.

Electrocautery Snare Is Combined with CO2 Cryosurgery and Argon Plasma Coagulation for the Treatment of Airway Tumors and Granulomas
Background and objective To observe the clinical effects and safety of endobronchial electrocautery snare combined with CO2 cryosurgery for the treatment of tracheobronchial obstructive lesions. Materials and methods Seventy-seven patients with airway tumor or granuloma were retrospectively reviewed, including 70 malignant airway obstruction and 7 benign airway lesions, for the treatment of endobronchial electrocautery snare plus CO2 cryosurgery and argon plasma coagulation (APC). Results Eighty-five endobronchial snares were performed in 77 cases. 42.9% of the obstructive lesions were located in right bronchial orifice, 3...
Source: Chinese Journal of Lung Cancer - June 15, 2013 Category: Cancer & Oncology Source Type: research

Combination of Narrow-band Imaging and Autofluorescence Imaging  Videobronchoscopy in the Assessment of Lung Cancer
Background and objective Narrow-band imaging (NBI) and autofluorescence imaging (AFI) are new bronchoscopy technologies that are important in lung cancer diagnosis. The aim of this study is to determine whether or not the combination of these two technologies can improve sensitivity and specificity of lung cancer diagnosis. Methods A total of 137 patients who manifested symptoms of lung cancer were investigated in this project. All of the examinations were performed based on an Olympus Evis Lucera bronchoscopy system. The patients were examined by white light bronchoscopy (WLB), NBI and AFI. At least three biopsies from bo...
Source: Chinese Journal of Lung Cancer - June 15, 2013 Category: Cancer & Oncology Source Type: research

Detection and Evaluation of EGFR Mutation Status in Serum of Patients with Advanced Non-small Cell Lung Cancer Treated with EGFR-TKIs
We examined EGFR mutation status in serum of 80 patients with advanced, EGFR-TKIs given as first-line therapy NSCLC. All patients were received long-term follow-up, and the drug efficacy were observed and evaluated. Results The EGFR mutation in serum was detected in 33.8% (27/80) of NSCLC patients examined, in which exon 19 deletion mutation was present at a frequency of 44.4% (12/27) and exon 21 point mutation was 55.6% (15/27); The response rate to EGFR-TKI in patients with EGFR mutation in serum was (55.6%, 15/27), which was remarkably higher than that in EGFR wild-type patients (17.0%, 9/53), the difference was statist...
Source: Chinese Journal of Lung Cancer - June 15, 2013 Category: Cancer & Oncology Source Type: research

Expression and Significance of MAGE Genes in Human Lung Cancer
Lung cancer is one of the common malignancies with an extremely poor prognosis, because of the current diagnostic techniques are not easy to find micrometastases. Melanoma associated antigens genes (MAGE) are tumor specific antigen genes, closely related to the occurrence, development and prognosis of lung cancer. The research of MAGE genes provide a new direction for the diagnosis and treatment of lung cancer. DOI: 10.3779/j.issn.1009-3419.2013.06.07 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 15, 2013 Category: Cancer & Oncology Source Type: research

Advanced Research on T790M Mutation in Non-small Cell Lung Cancer
Patients with advanced non-small cell lung cancer (NSCLC) carrying epidermal growth factor receptor (EGFR) activating mutations benefit from EGFR-tyrosine kinase inhibitor (TKI) treatment, however, most of TKI-treated patients eventually suffer drug resistant after 10-month treatments. Previous studies demonstrated that T790M mutation in exon 20 of EGFR gene would be the essential factor leading to EGFR-TKI resistance, leaving the mechanisms of which elucidative. Current research identified that T790M is an independent, favorable prognostic factor for predicting survival, but whether it is also a predictive biomarker for E...
Source: Chinese Journal of Lung Cancer - June 15, 2013 Category: Cancer & Oncology Source Type: research

Clinical Research of Crizotinib in Advanced Non-small Cell Lung Cancer
In this study, a review is performed in the mechanism and pharmacokinetics of crizotinib, and the clinical progress of treatment in advanced NSCLC. DOI: 10.3779/j.issn.1009-3419.2013.06.09 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 15, 2013 Category: Cancer & Oncology Source Type: research

Long-term Survival of A Patient with Advanced Non-small Cell Lung Cancer  on Bevacizumab Therapy: Case Report and Review of the Literature
We report an advanced stage Chinese female lung adenocarcinoma patient who was negative for epidermal growth factor receptor (EGFR), V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) gene mutations, also negative for chinodem microtubule-associated protein-like 4/anaplastic lymphoma kinase (EML4-ALK) gene rearrangement and treated with bevacizumab (15 mg/kg) in combination with 6 cycles of conventional doses of paclitaxel and carboplatin chemotherapy. She was then treated with maintenance bevacizumab for a total of 42 cycles, the total dose of bevacizumab is 44,730 mg. The progression-free survival was 39 months....
Source: Chinese Journal of Lung Cancer - June 15, 2013 Category: Cancer & Oncology Source Type: research

A Case Report of Patient with Advanced Non-small Cell Lung Cancer by Five Times EGFR-TKIs Therapy
DOI: 10.3779/j.issn.1009-3419.2013.06.11 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 15, 2013 Category: Cancer & Oncology Source Type: research

Up-regulation of DLL1 May Promote the Chemotherapeutic Sensitivity  in Small Cell Lung Cancer
Conclusion Our results suggest that overexpression of DLL1 in small cell lung cancer may increase the sensitivity of cells to chemotherapeutic agents. DLL1 influence drug resistance of small cell lung cancer through activating transcription of downstream genes HES1 and HEY1. DOI: 10.3779/j.issn.1009-3419.2013.06.02 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 15, 2013 Category: Cancer & Oncology Source Type: research

A Comparative Study on the Diagnosis and Staging of Lung Cancer  between Mediastinoscopy and EBUS-TBNA
Background and objective Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has been gradually universal application, but its value in the preoperative staging of lung cancer and mediastinal mass biopsy remains to be explored. The aim of this study is to evaluate the value of clinical application between mediastinoscopy and EBUS-TBNA, desiring to provide an objective basis for the rational choice applications. Methods Between July 2009 and December 2012, mediastinoscopy patients with 361 cases accepted biopsy, including 199 cases of lung cancer and 162 cases of mediastinal mass of unknown origin, ...
Source: Chinese Journal of Lung Cancer - June 15, 2013 Category: Cancer & Oncology Source Type: research

Editorial Board
(Source: Cancer Letters)
Source: Cancer Letters - June 15, 2013 Category: Cancer & Oncology Source Type: research

Endoscopy in the diagnosis of intestinal graft‐versus‐host disease: Is lower endoscopy with biopsy as effective in diagnosis as upper endoscopy combined with lower endoscopy?
ConclusionUse of sigmoid biopsy for GvHD diagnosis is effective, safe, and less expensive compared to other endoscopic interventions. Pediatr Blood Cancer 2013;9999:XX–XX. © 2013 Wiley Periodicals, Inc. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - June 15, 2013 Category: Cancer & Oncology Authors: Kody R. Crowell, Raza A. Patel, Mark Fluchel, Amy Lowichik, Staci Bryson, John F. Pohl Tags: Research Article Source Type: research

Phase 2 trial of afatinib, an ErbB family blocker, in solid tumors genetically screened for target activation
CONCLUSIONSSingle‐agent afatinib activity was limited, yet encouraging, in selected tumors that were screened prospectively for target activation. The implementation of a biomarker‐driven approach using a low‐frequency biomarker for patient selection across multiple tumor types can be challenging. Cancer 2013. © 2013 American Cancer Society. (Source: Cancer)
Source: Cancer - June 15, 2013 Category: Cancer & Oncology Authors: Eunice L. Kwak, Geoffrey I. Shapiro, Seth M. Cohen, Carlos R. Becerra, Heinz‐Josef Lenz, Wen‐Fang Cheng, Wu-Chou Su, Meghan Robohn, Florence Le Maulf, Maximilian T. Lobmeyer, Vikram K. Chand, A. John Iafrate Tags: Original Article Source Type: research

An in-silico comparison of proton beam and IMRT for postoperative radiotherapy in completely resected stage IIIA non-small cell lung cancer
Conclusions: IMPT demonstrates a large decrease in dose to all OARs. PSPT, while reducing the low-dose lung bath, increases the volume of lung receiving high dose. Reductions are seen in dosimetric parameters predictive of radiation pneumonitis and cardiac morbidity and mortality. This reduction may correlate with a decrease in dose-limiting toxicity and improve the therapeutic ratio. (Source: Radiation Oncology)
Source: Radiation Oncology - June 15, 2013 Category: Cancer & Oncology Authors: Abigail BermanBoon-Keng TeoDerek DolneySamuel Swisher-McClureKambiz ShahnaziStefan BothRamesh Rengan Source Type: research

NVP-BEZ235, Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor, Prominently Enhances Radiosensitivity of Prostate Cancer Cell Line PC-3
Cancer Biotherapy & Radiopharmaceuticals , Vol. 0, No. 0. (Source: Cancer Biotherapy and Radiopharmaceuticals)
Source: Cancer Biotherapy and Radiopharmaceuticals - June 14, 2013 Category: Cancer & Oncology Tags: article Source Type: research

High HMGA2 expression and high body mass index negatively affect the prognosis of patients with ovarian cancer
Abstract HMGA2 is a small, non‐histone, chromatin‐associated protein with a key role in tumorigenesis and adipogenesis. Indeed, HMGA2 overexpression has been frequently detected in several malignant neoplasms and inhibition of its expression prevents thyroid cell transformation. Moreover, HMGA2 null mice show a pigmy phenotype with a great reduction in fat tissue. To investigate whether HMGA2 expression correlates with clinico‐pathological parameters and patient outcome, immunohistochemical analysis of HMGA2 expression was performed in ovarian cancer specimens from 117 patients.HMGA2 overexpression was found in 39% o...
Source: Journal of Cellular Physiology - June 14, 2013 Category: Cytology Authors: Daniela Califano, Sandro Pignata, Nunzia Simona Losito, Alessandro Ottaiano, Stefano Greggi, Veronica De Simone, Sabrina Cecere, Concetta Aiello, Francesco Esposito, Alfredo Fusco, Gennaro Chiappetta Tags: Original Research Article Source Type: research

Lovelace puts new cancer-fighting technology to use
Lovelace Medical Center in Albuquerque was the first U.S. hospital to flip a switch and activate a new cancer-fighting technology that the hospital says can zap cancerous tumors in half the time as previous technology did, according to hospital officials. Lovelace activated the technology, called Dynamic Jaws, about six weeks ago. It’s part of the hospital’s treatment equipment that uses imaging and radiation to treat cancer patients, said Dr. Paul Anthony, medical director of Lovelace’s Cancer… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - June 14, 2013 Category: American Health Authors: Dennis Domrzalski Source Type: research

Elucidating the role of microRNAs in cancer through data mining techniques.
Abstract microRNAs (miRNAs) have been shown to play a crucial role in the most important biological processes and their dysregulation has been connected to a variety of diseases, including cancer. The number of computational tools for the analysis of miRNA related data is continuously increasing. They range from simple look-up resources to more sophisticated tools for functional analysis of miRNAs. These systems may help to investigate the role of miRNAs in key biological processes and their involvement in diseases. The ultimate goal is to allow the development of regulatory models describing complex processes and ...
Source: Adv Data - June 14, 2013 Category: Epidemiology Authors: Cascione L, Ferro A, Giugno R, Laganà A, Pigola G, Pulvirenti A, Veneziano D Tags: Adv Exp Med Biol Source Type: research

Discovery of microRNA regulatory networks by integrating multidimensional high-throughput data.
Abstract MicroRNAs (miRNAs) are endogenous non-coding RNAs (ncRNAs) of approximately 22 nt that regulate the expression of a large fraction of genes by targeting messenger RNAs (mRNAs). However, determining the biologically significant targets of miRNAs is an ongoing challenge. In this chapter, we describe how to identify miRNA-target interactions and miRNA regulatory networks from high-throughput deep sequencing, CLIP-Seq (HITS-CLIP, PAR-CLIP) and degradome sequencing data using starBase platforms. In starBase, several web-based and stand-alone computational tools were developed to discover Argonaute (Ago) binding...
Source: Adv Data - June 14, 2013 Category: Epidemiology Authors: Yang JH, Qu LH Tags: Adv Exp Med Biol Source Type: research

MicroRNA-regulated networks: the perfect storm for classical molecular biology, the ideal scenario for systems biology.
Abstract MicroRNAs (miRNAs) are involved in many regulatory pathways some of which are complex networks enriched in regulatory motifs like positive or negative feedback loops or coherent and incoherent feedforward loops. Their complexity makes the understanding of their regulation difficult and the interpretation of experimental data cumbersome. In this book chapter we claim that systems biology is the appropriate approach to investigate the regulation of these miRNA-regulated networks. Systems biology is an interdisciplinary approach by which biomedical questions on biochemical networks are addressed by integratin...
Source: Adv Data - June 14, 2013 Category: Epidemiology Authors: Vera J, Lai X, Schmitz U, Wolkenhauer O Tags: Adv Exp Med Biol Source Type: research

Bioinformatics, non-coding RNAs and its possible application in personalized medicine.
Abstract Non-coding RNAs are important actors in human biology. A massive amount of data has been created and manipulated, and important findings have been extracted thanks in part to bioinformatics approaches and consequent experimental validation; many of these results are for a specific class of non-coding RNAs, the microRNAs (miRNAs), that are important regulators of gene expression although their transcriptional regulation is not yet well understood. Their involvement in cancer development and progression makes the related research field an integrated one, composed of bioinformaticians, clinicians, statisticia...
Source: Adv Data - June 14, 2013 Category: Epidemiology Authors: Rossi S, Calin GA Tags: Adv Exp Med Biol Source Type: research

MicroRNAs in human cancer.
Abstract Mature microRNAs (miRNAs) are single-stranded RNA molecules of 20-23-nucleotide (nt) length that control gene expression in many cellular processes. These molecules typically reduce the translation and stability of mRNAs, including those of genes that mediate processes in tumorigenesis, such as inflammation, cell cycle regulation, stress response, differentiation, apoptosis, and invasion. miRNA targeting is initiated through specific base-pairing interactions between the 5' end ("seed" region) of the miRNA and sites within coding and untranslated regions (UTRs) of mRNAs; target sites in the 3' UTR lead to ...
Source: Adv Data - June 14, 2013 Category: Epidemiology Authors: Farazi TA, Hoell JI, Morozov P, Tuschl T Tags: Adv Exp Med Biol Source Type: research

Court ruling on genes is a "victory for common sense"
Mary-Claire King, who discovered the BRCA1 and BRCA2 cancer-related genes, says she is delighted by the US Supreme Court ruling that makes it illegal to patent them (Source: New Scientist - Health)
Source: New Scientist - Health - June 14, 2013 Category: Consumer Health News Source Type: research

In Vitro Evidence of the Presence of Mesenchymal Stromal Cells in Cervical Cancer and Their Role in Protecting Cancer Cells from Cytotoxic T Cell Activity
Stem Cells and Development , Vol. 0, No. 0. (Source: Stem Cells and Development)
Source: Stem Cells and Development - June 14, 2013 Category: Stem Cells Tags: article Source Type: research

A Human Thyroid Cancer Cell Line, DH-14-3, Newly Established from Poorly Differentiated Thyroid Carcinoma.
Abstract Poorly differentiated thyroid carcinoma (PDTC) is a newly recognized histological type of malignant thyroid tumor, accounting for about 2 - 13% of all thyroid carcinomas. PDTC is considered as a morphologically and biologically intermediate stage between well-differentiated thyroid carcinoma and anaplastic thyroid carcinoma. PDTC preferentially manifests bone metastases. We here established a cell line from a resected tumor specimen from a 70-year-old male patient with PDTC who presented with multiple bone metastases. This new thyroid tumor cell line was designated as DH-14-3 and was subsequently grown in ...
Source: The Tohoku Journal of Experimental Medicine - June 14, 2013 Category: Research Authors: Teshima J, Doi H, Fujimori K, Watanabe M, Nakajima N, Nakano T, Takahashi Y, Ohuchi N, Satomi S Tags: Tohoku J Exp Med Source Type: research

Interpretation of IASLC/ATS/ERS International Multidisciplinary Classification of Lung Neoplasms
DOI: 10.3779/j.issn.1009-3419.2013.06.01 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - June 14, 2013 Category: Cancer & Oncology Source Type: research

Analysis of obstetrics and gynecology professional liability claims in Catalonia, Spain (1986–2010)
Conclusion: OG is at high-risk for malpractice claims, but compensation awards are not frequent. However, particular events, such as retained foreign objects, tubal ligation, ultrasound diagnosis or neurologically impaired newborns, deserve special attention regarding medico-legal issues. (Source: Journal of Forensic and Legal Medicine)
Source: Journal of Forensic and Legal Medicine - June 14, 2013 Category: Forensic Medicine Authors: Esperanza L. Gómez-Durán, Joan Antoni Mulà-Rosías, Josep Maria Lailla-Vicens, Josep Benet-Travé, Josep Arimany-Manso Tags: Original Communications Source Type: research

Cervical cancer risk factors among HIV-infected Nigerian women
Conclusion: The prevalence of screening positive lesions or cervical cancer was lower than most previous reports from Africa. HIV-positive Nigerian women were at a marginally increased risk of cervical pre-cancer and cancer. These findings highlight the need for more epidemiological studies of cervical cancer and pre-cancerous lesions among HIV-positive women in Africa and an improved understanding of incidence and risk factors. (Source: BMC Public Health - Latest articles)
Source: BMC Public Health - Latest articles - June 14, 2013 Category: Consumer Health News Authors: Uzoma OnonogbuMaryam AlmujtabaFatima ModibboIshak LawalRichard OffiongOlayinka OlaniyanPatrick DakumDonna SpiegelmanWilliam BlattnerClement Adebamowo Source Type: research

Melanoma inhibitory activity promotes melanoma development through activation of YBX1
In this study, we characterize the transcriptional regulation of p54nrb by MIA to explain MIA's molecular action. We identified one highly conserved region in the p54nrb promoter that is necessary and sufficient for MIA‐dependent activation. Functional promoter analysis identified the transcription factor YBX1 as the mediator of MIA activation of p54nrb transcription. We screened the genome for further potential MIA‐regulated genes carrying the element in their promoter regions. Integrating our sequence data with expression data from human melanomas identified a list of 23 potential MIA‐YBX1 targets in melanomas. In ...
Source: Pigment Cell Research - June 14, 2013 Category: Cytology Authors: Rainer Schmid, Katharina Meyer, Rainer Spang, Birgit Schittek, Anja‐Katrin Bosserhoff Tags: Original Article Source Type: research

Celastrol and attenuation of tumor growth in systemic malignancies: A clinical perspective
Wang et al have provided interesting data in their recent article1. Interestingly, recent data suggests that celastrol exerts significant anti‐ neoplastic effects in other systemic malignancies.For instance, celastrol inhibits tumor growth in breast malignancies. (Source: Journal of Cellular Physiology)
Source: Journal of Cellular Physiology - June 14, 2013 Category: Cytology Authors: Shailendra Kapoor Tags: Letter to the Editor Source Type: research

MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition, anoikis resistance and invasion in gastric cancer cells
Conclusion: Our results suggest that down-regulation of miR-204 promotes gastric cancer cell invasion by activating the SIRT1-LKB1 pathway. These data demonstrate that miR-204 plays an important role in regulating metastasis of gastric cancer, which is involved in post-transcriptional repression of SIRT1. (Source: BMC Cancer)
Source: BMC Cancer - June 14, 2013 Category: Cancer & Oncology Authors: Lihua ZhangXueqing WangPingsheng Chen Source Type: research

Profiling of normal and malignant breast tissue show CD44high/CD24low phenotype as a predominant stem/progenitor marker when used in combination with Ep-CAM/CD49f markers
Conclusion: Our study clearly demonstrates that both normal and malignant breast cells with the CD44high/CD24low phenotype have the highest stem/progenitor cell ability when used in combination with Ep-CAM/CD49f reference markers. We believe that this extensive characterization study will help in understanding breast cancer carcinogenesis, heterogeneity and drug resistance. (Source: BMC Cancer)
Source: BMC Cancer - June 14, 2013 Category: Cancer & Oncology Authors: Hazem GhebehGhida SleimanPulicat ManogaranAmer Al-MazrouEman BarhoushFalah Al-MohannaAsma TulbahKhalid Al-FaqeehChaker Adra Source Type: research