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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 22.

The Leukemia & Lymphoma Society: Impacting Blood Cancers and...
In 1964, the five-year survival rate for the most common form of childhood leukemia was only three percent but, today, thanks to treatment advances, about 90 percent of children survive. As the...(PRWeb February 21, 2013)Read the full story at http://www.prweb.com/releases/2013/2/prweb10455005.htm
Source: PRWeb: Medical Pharmaceuticals - February 22, 2013 Category: Pharmaceuticals Source Type: news

Current and historical perspectives on methodological flaws in processing umbilical cord blood.
Abstract Umbilical cord blood (UCB) hematopoietic stem cells (HSC-CD34+) are valuable for treating malignant or nonmalignant disease. Processing UCB by HESPAN-6% and anti-CD34-Miltenyi particles provides insufficient cells for treating adults. Physicochemical-electrokinetic studies on UCB-mononuclear cells (MNCs) under conditions of delayed processing, ice or very low temperatures, and some cell separation media identified artifacts introduced by procedures. Adsorption of biomaterials from cell damage by temperature, degradation products after using enzymes, harsh reagents, dithiothreitol, and HESPAN affect cell pr...
Source: Transfusion - February 22, 2013 Category: Hematology Authors: Mehrishi JN Tags: Transfusion Source Type: research

A novel method of CD34+ cell separation from umbilical cord blood.
CONCLUSIONS: Achieving approximately 5% CD34+ cell yields from single UCB donations, a major advance, holds great promise for CD34+ cell therapy of adults and larger children, and cheaper cultured RBC manufacture. PMID: 23432618 [PubMed - as supplied by publisher]
Source: Transfusion - February 22, 2013 Category: Hematology Authors: Mehrishi JN, Bakács T Tags: Transfusion Source Type: research

A Tertiary Center's Experience With Second Review of 3885 Thyroid Cytopathology Specimens.
Conclusion:This is the largest series to date of thyroid cytology second review. The BSRTC classification changed 32% of the time, potentially resulting in significant changes in clinical and surgical management. Because certain specimen characteristics (indeterminate diagnostic category before second review, low specimen cellularity, Hashimoto's thyroiditis, and low volume of consults from the sending institution) were particularly associated with a diagnosis change, morphological second review may be of potential benefit in these settings. PMID: 23436916 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - February 22, 2013 Category: Endocrinology Authors: Olson MT, Boonyaarunnate T, Aragon Han P, Umbricht CB, Ali SZ, Zeiger MA Tags: J Clin Endocrinol Metab Source Type: research

Bone Metastases and Skeletal-Related Events in Patients with Malignant Pheochromocytoma and Sympathetic Paraganglioma.
Conclusions:BM and SREs are frequent in patients with malignant PHEO/sPGL. SREs often develop shortly after the diagnosis of BM; severe pain is the most frequent SRE. These patients should be followed long-term by a multidisciplinary team to promptly identify the need for medical or surgical intervention. PMID: 23436918 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - February 22, 2013 Category: Endocrinology Authors: Ayala-Ramirez M, Palmer JL, Hoffman MC, de la Cruz M, Moon BS, Waguespack SG, Habra MA, Jimenez C Tags: J Clin Endocrinol Metab Source Type: research

Low- or High-Dose Radioiodine Remnant Ablation for Differentiated Thyroid Carcinoma: A Meta-Analysis.
Conclusions:The low dose of 1100 MBq radioiodine activity is sufficient for thyroid remnant ablation as compared to 3700 MBq radioiodine activity with similar quality of life, less common adverse effects, and a shorter hospital stay. PMID: 23436920 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - February 22, 2013 Category: Endocrinology Authors: Cheng W, Ma C, Fu H, Li J, Chen S, Wu S, Wang H Tags: J Clin Endocrinol Metab Source Type: research

JAK2 46/1 haplotype is associated with JAK2 V617F-positive myeloproliferative neoplasms in Japanese patients.
In conclusion, we demonstrated that the JAK2 46/1 haplotype is associated with JAK2 V617F-positive MPNs in Japanese patients. PMID: 23430670 [PubMed - as supplied by publisher]
Source: International Journal of Hematology - February 22, 2013 Category: Hematology Authors: Tanaka M, Yujiri T, Ito S, Okayama N, Takahashi T, Shinohara K, Azuno Y, Nawata R, Hinoda Y, Tanizawa Y Tags: Int J Hematol Source Type: research

Risk factors influencing mortality related to Stenotrophomonas maltophilia infection in hematology-oncology patients.
The objective of this study was to analyze the clinical characteristics and outcomes of cancer and hemopathic patients with S. maltophilia infection and assess the factors influencing the mortality. The microbiology laboratory records of Erciyes University, Faculty of Medicine Hospital were reviewed to retrospectively identify patients with S. maltophilia infection between January 2007 and June 2011. A total of 38 patients (25 male, 13 female) were eligible for the study. The median age of the patients was 53 years. The underlying disease was hematological malignancy and disorders in 76.3 % (29 cases), solid tumors in 15...
Source: International Journal of Hematology - February 22, 2013 Category: Hematology Authors: Demiraslan H, Sevim M, Pala C, Durmaz S, Berk V, Kaynar L, Metan G Tags: Int J Hematol Source Type: research

Population Pharmacokinetic Model for Cancer Chemoprevention With Sulindac in Healthy Subjects.
Abstract Sulindac is a prescription-based non-steroidal anti-inflammatory drug (NSAID) that continues to be actively investigated as a candidate cancer chemoprevention agent. To further current understanding of sulindac bioavailability, metabolism, and disposition, we developed a population pharmacokinetic model for the parent compound and its active metabolites, sulindac sulfide, and exisulind. This analysis was based on data from 24 healthy subjects who participated in a bioequivalence study comparing two formulations of sulindac. The complex disposition of sulindac and its metabolites was described by a seven-co...
Source: The Journal of Clinical Pharmacology - February 22, 2013 Category: Drugs & Pharmacology Authors: Berg AK, Mandrekar SJ, Ziegler KL, Carlson EC, Szabo E, Ames MM, Boring D, Limburg PJ, Reid JM, ; For the Cancer Prevention Network Tags: J Clin Pharmacol Source Type: research

A prospective observational study on 249 subcutaneous central vein access ports in a Swedish county hospital.
Conclusion. These results confirm that our team-based approach with written easily accessible evidence-based guidelines and a structured education programme leads to a very low complication rate and a high degree of patient satisfaction. PMID: 23432403 [PubMed - as supplied by publisher]
Source: Acta Oncologica - February 22, 2013 Category: Cancer & Oncology Authors: Taxbro K, Berg S, Hammarskjöld F, Hanberger H, Malmvall BE Tags: Acta Oncol Source Type: research

Differential mutation profiles and similar intronic TP53 polymorphisms in asbestos-related lung cancer and pleural mesothelioma.
Jaurand MC, Jean D Abstract Given the interest in defining biomarkers of asbestos exposure and to provide insights into asbestos-related and cell-specific mechanisms of neoplasia, the identification of gene alterations in asbestos-related cancers can help to a better understanding of exposure risk. To understand the aetiology of asbestos-induced malignancies and to increase our knowledge of mesothelial carcinogenesis, we compared genetic alterations in relevant cancer genes between lung cancer, induced by asbestos and tobacco smoke, and malignant pleural mesothelioma (MPM), a cancer related to asbestos, but not to ...
Source: Clinical Lung Cancer - February 22, 2013 Category: Cancer & Oncology Authors: Andujar P, Pairon JC, Renier A, Descatha A, Hysi I, Abd-Alsamad I, Billon-Galland MA, Blons H, Clin B, Danel C, Debrosse D, Galateau-Sallé F, Housset B, Laurent-Puig P, Le Pimpec-Barthes F, Letourneux M, Monnet I, Régnard JF, Validire P, Zucman-Rossi J, Tags: Mutagenesis Source Type: research

Multicenter Phase I Trial of the Mitogen-Activated Protein Kinase 1/2 Inhibitor BAY 86-9766 in Patients with Advanced Cancer.
CONCLUSION: This phase I study showed that BAY 86-9766 was well-tolerated, with good oral absorption, dose proportional pharmacokinetics, target inhibition at the MTD, and some evidence of clinical benefit across a range of tumor types. Clin Cancer Res; 19(5); 1-43. ©2012 AACR. PMID: 23434733 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - February 22, 2013 Category: Cancer & Oncology Authors: Weekes CD, Von Hoff DD, Adjei AA, Leffingwell DP, Eckhardt SG, Gore L, Lewis KD, Weiss GJ, Ramanathan RK, Dy GK, Ma WW, Sheedy B, Iverson C, Miner JN, Shen Z, Yeh LT, Dubowy RL, Jeffers M, Rajagopalan P, Clendeninn NJ Tags: Clin Cancer Res Source Type: research

The Combination of Sorafenib and Everolimus abrogates mTORC-1 and mTORC2 up-regulation in preclinical models of Osteosarcoma.
CONCLUSION: mTORC2 activation is an escape mechanism from sorafenib treatment. When sorafenib is combined with everolimus, its anti-tumor activity is increased by complete inhibition of the mTOR pathway in the preclinical setting. PMID: 23434734 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - February 22, 2013 Category: Cancer & Oncology Authors: Pignochino Y, Dell'aglio C, Basirico M, Capozzi F, Soster M, Marchio S, Bruno S, Gammaitoni L, Sangiolo D, Torchiaro E, D'Ambrosio L, Fagioli F, Ferrari S, Alberghini M, Picci P, Aglietta M, Grignani G Tags: Clin Cancer Res Source Type: research

Overcoming regulatory T-cell suppression by a lyophilized preparation of Streptococcus pyogenes.
Abstract Cancer vaccines have yet to yield clinical benefit, despite the measurable induction of humoral and cellular immune responses. As immunosuppression by CD4(+) CD25(+) regulatory T (Treg) cells has been linked to the failure of cancer immunotherapy, blocking suppression is therefore critical for successful clinical strategies. Here, we addressed whether a lyophilized preparation of Streptococcus pyogenes (OK-432), which stimulates Toll-like receptors, could overcome Treg-cell suppression of CD4(+) T-cell responses in vitro and in vivo. OK-432 significantly enhanced in vitro proliferation of CD4(+) effector T...
Source: European Journal of Immunology - February 22, 2013 Category: Allergy & Immunology Authors: Hirayama M, Nishikawa H, Nagata Y, Tsuji T, Kato T, Kageyama S, Ueda S, Sugiyama D, Hori S, Sakaguchi S, Ritter G, Old LJ, Gnjatic S, Shiku H Tags: Eur J Immunol Source Type: research

Localized Immunotherapy via Liposome-Anchored Anti-CD137 + IL-2 Prevents Lethal Toxicity and Elicits Local and Systemic Antitumor Immunity.
Abstract Immunostimulatory agonists such as anti-CD137 and interleukin (IL)-2 have elicited potent antitumor immune responses in preclinical studies, but their clinical use is limited by inflammatory toxicities that result upon systemic administration. We hypothesized that by rigorously restricting the biodistribution of immunotherapeutic agents to a locally accessible lesion and draining lymph node(s), effective local and systemic antitumor immunity could be achieved in the absence of systemic toxicity. We anchored anti-CD137 and an engineered IL-2Fc fusion protein to the surfaces of PEGylated liposomes, whose phy...
Source: Cell Research - February 22, 2013 Category: Cytology Authors: Kwong B, Gai SA, Elkhader J, Wittrup KD, Irvine DJ Tags: Cancer Res Source Type: research

Genome-wide methylation profiling and the PI3K-AKT pathway analysis associated with smoking in urothelial cell carcinoma.
Abstract Urothelial cell carcinoma (UCC) is the second most common genitourinary malignant disease in the USA, and tobacco smoking is the major known risk factor for UCC development. Exposure to carcinogens, such as those contained in tobacco smoke, is known to directly or indirectly damage DNA, causing mutations, chromosomal deletion events and epigenetic alterations in UCC. Molecular studies have shown that chromosome 9 alterations and P53, RAS, RB and PTEN mutations are among the most frequent events in UCC. Recent studies suggested that continuous tobacco carcinogen exposure drives and enhances the selection of...
Source: Cell Cycle - February 22, 2013 Category: Cytology Authors: Brait M, Munari E, Lebron C, Noordhuis MG, Begum S, Michailidi C, Gonzalez-Roibon N, Maldonado L, Sen T, Guerrero-Preston R, Cope L, Parrella P, Fazio VM, Ha PK, Netto GJ, Sidransky D, Hoque MO Tags: Cell Cycle Source Type: research

Dural closure for the treatment of superficial siderosis.
Abstract Superficial siderosis (SS) of the CNS is a rare disease caused by repeated hemorrhages in the subarachnoid space. The subsequent deposition of hemosiderin in the brain and spinal cord leads to the progression of neurological deficits. The causes of bleeding include prior intradural surgery, carcinoma, arteriovenous malformation, nerve root avulsion, and dural abnormality. Recently, surgical treatment of SS associated with dural defect has been reported. The authors of the present report describe 2 surgically treated SS cases and review the literature on surgically treated SS. The patients had dural defects...
Source: Journal of Neurosurgery.Spine - February 22, 2013 Category: Neurosurgery Authors: Egawa S, Yoshii T, Sakaki K, Inose H, Kato T, Kawabata S, Tomizawa S, Okawa A Tags: J Neurosurg Spine Source Type: research

Intraoperative flow cytometry analysis of glioma tissue for rapid determination of tumor presence and its histopathological grade.
Conclusions Results of this study demonstrate that iFC with the determination of the MI may be feasible for rapidly determining glioma presence in a surgical biopsy sample. PMID: 23432426 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - February 22, 2013 Category: Neurosurgery Authors: Shioyama T, Muragaki Y, Maruyama T, Komori T, Iseki H Tags: J Neurosurg Source Type: research

Study Finds Association Between Biological Marker and Susceptibility to the Common Cold
Preliminary study results suggest that a biomarker may be associated with the ability of young and middle-aged people to fight off a cold caused by a particular rhinovirus. The biological marker identified in the study was the length of telomeres—cap-like protein complexes at the ends of chromosomes—which shorten with age. Having shorter telomeres is known to be associated with the onset of aging-related diseases such as cardiovascular disease and cancer, and with mortality in older adults. The study was published in the Journal of the American Medical Association.
Source: NCCAM Featured Content - February 22, 2013 Category: Complementary Medicine Authors: NCCAM Source Type: news

Causes of false‐negative sentinel node biopsy in patients with breast cancer
ConclusionSLN serial sectioning contributes to a higher rate of detection of SLN metastasis. The rate of upstaging of the tumour is similar in false‐ and true‐negative groups of patients.
Source: British Journal of Surgery - February 22, 2013 Category: Surgery Authors: Y. Andersson, J. Frisell, M. Sylvan, J. Boniface, L. Bergkvist Tags: Original Article Source Type: research

UCLA researchers further refine 'NanoVelcro' device to grab single cancer cells from blood
(University of California - Los Angeles) Researchers at UCLA report that they have refined a method they previously developed for capturing and analyzing cancer cells that break away from patients' tumors and circulate in the blood. With the improvements to their device, which uses a Velcro-like nanoscale technology, they can now detect and isolate single cancer cells from patient blood samples for analysis.
Source: EurekAlert! - Medicine and Health - February 22, 2013 Category: Global & Universal Source Type: news

Overcoming regulatory T‐cell suppression by a lyophilized preparation of Streptococcus pyogenes
Abstract Cancer vaccines have yet to yield clinical benefit, despite the measurable induction of humoral and cellular immune responses. As immunosuppression by CD4+CD25+ regulatory T (Treg) cells has been linked to the failure of cancer immunotherapy, blocking suppression is therefore critical for successful clinical strategies. Here, we addressed whether a lyophilized preparation of Streptococcus pyogenes (OK‐432), which stimulates Toll‐like receptors, could overcome Treg‐cell suppression of CD4+ T‐cell responses in vitro and in vivo. OK‐432 significantly enhanced in vitro proliferation of CD4+ effector T cells ...
Source: European Journal of Immunology - February 22, 2013 Category: Allergy & Immunology Authors: Michiko Hirayama, Hiroyoshi Nishikawa, Yasuhiro Nagata, Takemasa Tsuji, Takuma Kato, Shinichi Kageyama, Shugo Ueda, Daisuke Sugiyama, Sahoko Hori, Shimon Sakaguchi, Gerd Ritter, Lloyd J. Old, Sacha Gnjatic, Hiroshi Shiku Tags: Regular Article Source Type: research

Residential proximity to industrial combustion facilities and risk of non-Hodgkin lymphoma: A case--control study
Conclusions: Overall, we found no association with residential exposure to dioxins and NHL risk. However, findings for high emissions and marginal zone lymphoma and for specific facility types and all NHL provide some evidence of an association and deserve future study.
Source: Environmental Health - February 22, 2013 Category: Environmental Health Authors: Anjoeka PronkJohn NuckolsAnneclaire De RoosMatthew AirolaJoanne ColtJames CerhanLindsay MortonWendy CozenRichard SeversonAaron BlairDavid CleverlyMary Ward Source Type: research

Changes in mortality and causes of death in the Swedish Down syndrome population
Abstract During the past few decades age at death for individuals with Down syndrome (DS) has increased dramatically. The birth frequency of infants with DS has long been constant in Sweden. Thus, the prevalence of DS in the population is increasing. The aim of the present study was to analyze mortality and causes of death in individuals with DS during the period 1969–2003. All individuals with DS that died between 1969 and 2003 in Sweden, and all individuals born with DS in Sweden between 1974 and 2003 were included. Data were obtained from the Swedish Medical Birth Register, the Swedish Birth Defects Register, and the ...
Source: American Journal of Medical Genetics Part A - February 22, 2013 Category: Genetics & Stem Cells Authors: Annika Englund, Björn Jonsson, Cecilia Soussi Zander, Jan Gustafsson, Göran Annerén Tags: Research Article Source Type: research

Association between CD8+ T‐cell subsets and cardiovascular disease
ConclusionThis study provides prospective clinical evidence for a role of CD8+ T cells in cardiovascular disease and suggests the existence of CD8+ T‐cell subsets with different pathological functions.
Source: Journal of Internal Medicine - February 22, 2013 Category: Internal Medicine Authors: D. Kolbus, I. Ljungcrantz, L. Andersson, B. Hedblad, G. N. Fredrikson, H. Björkbacka, J. Nilsson Tags: Original Article Source Type: research

Long‐term treatment with romiplostim in patients with chronic immune thrombocytopenia: safety and efficacy
In conclusion, this study demonstrated that romiplostim was safe and well‐tolerated over 614 patient‐years of exposure in ITP patients, and that efficacy was maintained with stable dosing for up to 5 years of continuous treatment.
Source: British Journal of Haematology - February 22, 2013 Category: Hematology Authors: David J. Kuter, James B. Bussel, Adrian Newland, Ross I. Baker, Roger M. Lyons, Jeffrey Wasser, Jean‐Francois Viallard, Gail Macik, Mathias Rummel, Kun Nie, Susie Jun Tags: Research Paper Source Type: research

Invasive cancer incidence - United States, 2009.
This report summarizes the most recent invasive cancer incidence rates by sex, age, race, ethnicity, primary site, and state of residence using data from U.S. Cancer Statistics (USCS) for 2009. USCS includes incidence data from CDC's National Program of Cancer Registries (NPCR) and the National Cancer Institute's (NCI's) Surveillance, Epidemiology, and End Results (SEER) program and mortality data from the National Vital Statistics System. In 2009, a total of 1,476,504 invasive cancers were diagnosed in the United States, an annual incidence rate of 459 cases per 100,000 persons. Cancer incidence rates were higher among me...
Source: MMWR Morb Mortal Wkl... - February 22, 2013 Category: Epidemiology Authors: Centers for Disease Control and Prevention (CDC) Tags: MMWR Morb Mortal Wkly Rep Source Type: research

Disparities in Knowledge of Mouth or Throat Cancer Among Rural Floridians
Conclusions: This study adds to the literature on MTC knowledge and concern because this sample was drawn exclusively from rural populations in North Florida, a group with the highest MTC morbidity and mortality. An unanticipated finding was that blacks were more concerned than their white rural counterparts. This study was also the first to report that depression was associated with increased concern about MTC. The goal is to persuade at‐risk groups to obtain MTC screenings with the goal of reducing disparities in MTC whenever they occur.
Source: The Journal of Rural Health - February 22, 2013 Category: Rural Health Authors: Joseph L. Riley III, Elizabeth A. Pomery, Virginia J. Dodd, Keith E Muller, Yi Guo, Henrietta L. Logan Tags: ORIGINAL ARTICLE Source Type: research

Shotgun proteomics of archival triple negative breast cancer samples
Conclusion and clinical relevanceOur results open up new avenues for the use of proteomics technologies in clinically relevant studies using archival samples. Shotgun LC‐MS/MS studies could serve to discover new biomarkers and may provide clues to the genesis of triple negative breast cancer and underlying molecular alterations.
Source: Proteomics. Clinical Applications - February 22, 2013 Category: Biochemistry Authors: Angelo Gámez‐Pozo, Nuria Ibarz Ferrer, Eva Ciruelos, Rocío López‐Vacas, Fernando García Martínez, Enrique Espinosa, Juan Ángel Fresno Vara Tags: Research Article Source Type: research

Impact of p110{alpha} Inhibitors in Primary Lymphocytes [Signal Transduction]
Class IA phosphoinositide 3-kinase (PI3K) is essential for clonal expansion, differentiation, and effector function of B and T lymphocytes. The p110δ catalytic isoform of PI3K is highly expressed in lymphocytes and plays a prominent role in B and T cell responses. Another class IA PI3K catalytic isoform, p110α, is a promising drug target in cancer but little is known about its function in lymphocytes. Here we used highly selective inhibitors to probe the function of p110α in lymphocyte responses in vitro and in vivo. p110α inhibition partially reduced B cell receptor (BCR)-dependent AKT activation and proliferation, an...
Source: Journal of Biological Chemistry - February 22, 2013 Category: Chemistry Authors: So, L., Yea, S. S., Oak, J. S., Lu, M., Manmadhan, A., Ke, Q. H., Janes, M. R., Kessler, L. V., Kucharski, J. M., Li, L.-S., Martin, M. B., Ren, P., Jessen, K. A., Liu, Y., Rommel, C., Fruman, D. A. Tags: Immunology Source Type: research

Mitochondrial Regulation of Cell Motility [Signal Transduction]
Mitochondria control bioenergetics and cell fate decisions, but how they influence nuclear gene expression is understood poorly. Here, we show that deletion or reduction in the levels of cyclophilin D (CypD, also called Ppif), a mitochondrial matrix peptidyl prolyl isomerase and apoptosis regulator, results in increased cell proliferation and enhanced cell migration and invasion. These responses are associated with extensive transcriptional changes, modulation of a chemokine/chemokine receptor gene signature, and activation of the pleiotropic inflammatory mediator, STAT3. In the absence of CypD, active STAT3 enhances cell ...
Source: Journal of Biological Chemistry - February 22, 2013 Category: Chemistry Authors: Tavecchio, M., Lisanti, S., Lam, A., Ghosh, J. C., Martin, N. M., O'Connell, M., Weeraratna, A. T., Kossenkov, A. V., Showe, L. C., Altieri, D. C. Tags: Cell Biology Source Type: research

Role of p21WAF1 in IL-20-induced Migration [Cell Biology]
The role of inflammatory cytokine interleukin-20 (IL-20) has not yet been studied in cancer biology. Here, we demonstrated up-regulation of both IL-20 and IL-20R1 in muscle-invasive bladder cancer patients. The expressions of IL-20 and IL-20R1 were observed in bladder cancer 5637 and T-24 cells. We found that IL-20 significantly increased the expression of matrix metalloproteinase (MMP)-9 via binding activity of NF-κB and AP-1 in bladder cancer cells and stimulated the activation of ERK1/2, JNK, p38 MAPK, and JAK-STAT signaling. Among the pathways examined, only ERK1/2 inhibitor U0126 significantly inhibited IL-20-induced...
Source: Journal of Biological Chemistry - February 22, 2013 Category: Chemistry Authors: Lee, S.-J., Cho, S.-C., Lee, E.-J., Kim, S., Lee, S.-B., Lim, J.-H., Choi, Y. H., Kim, W.-J., Moon, S.-K. Tags: Immunology Source Type: research

Cdc37-Vav3 Interaction in AR Co-activation [Molecular Bases of Disease]
Elevated androgen receptor (AR) activity in castration-resistant prostate cancer may occur through increased levels of AR co-activator proteins. Vav3, a guanine nucleotide exchange factor, is up-regulated following progression to castration resistance in preclinical models and is overexpressed in a significant number of human prostate cancers. Vav3 is a novel co-activator of the AR. We sought to identify Vav3 binding partners in an effort to understand the molecular mechanisms underlying Vav3 enhancement of AR activity and to identify new therapeutic targets. The cell division cycle 37 homolog (Cdc37), a protein kinase-spe...
Source: Journal of Biological Chemistry - February 22, 2013 Category: Chemistry Authors: Wu, F., Peacock, S. O., Rao, S., Lemmon, S. K., Burnstein, K. L. Tags: Gene Regulation Source Type: research

MINIREVIEW: Structure and Dynamic Regulation of Abl Kinases [Molecular Bases of Disease]
The c-abl proto-oncogene encodes a unique protein-tyrosine kinase (Abl) distinct from c-Src, c-Fes, and other cytoplasmic tyrosine kinases. In normal cells, Abl plays prominent roles in cellular responses to genotoxic stress as well as in the regulation of the actin cytoskeleton. Abl is also well known in the context of Bcr-Abl, the oncogenic fusion protein characteristic of chronic myelogenous leukemia. Selective inhibitors of Bcr-Abl, of which imatinib is the prototype, have had a tremendous impact on clinical outcomes in chronic myelogenous leukemia and revolutionized the field of targeted cancer therapy. In this minire...
Source: Journal of Biological Chemistry - February 22, 2013 Category: Chemistry Authors: Panjarian, S., Iacob, R. E., Chen, S., Engen, J. R., Smithgall, T. E. Tags: Minireviews Source Type: research

REPORT: N-Glycans Are Essential for rhLOXL2 Secretion [Glycobiology and Extracellular Matrices]
Human lysyl oxidase-like 2 (hLOXL2) is highly up-regulated in metastatic breast cancer cells and tissues and induces epithelial-to-mesenchymal transition, the first step of metastasis/invasion. hloxl2 encodes four N-terminal scavenger receptor cysteine-rich domains and the highly conserved C-terminal lysyl oxidase (LOX) catalytic domain. Here, we assessed the extent of the post-translational modifications of hLOXL2 using truncated recombinant proteins produced in Drosophila S2 cells. The recombinant proteins are soluble, in contrast to LOX, which is consistently reported to require 2–6 m urea for solubilization. The reco...
Source: Journal of Biological Chemistry - February 22, 2013 Category: Chemistry Authors: Xu, L., Go, E. P., Finney, J., Moon, H., Lantz, M., Rebecchi, K., Desaire, H., Mure, M. Tags: Reports Source Type: research

Plurality of opinion, scientific discourse and pseudoscience: an in depth analysis of the Séralini et al. study claiming that Roundup™ Ready corn or the herbicide Roundup™ cause cancer in rats.
Abstract A recent paper published in the journal Food and Chemical Toxicology presents the results of a long-term toxicity study related to a widely-used commercial herbicide (Roundup™) and a Roundup-tolerant genetically modified variety of maize, concluding that both the herbicide and the maize varieties are toxic. Here we discuss the many errors and inaccuracies in the published article resulting in highly misleading conclusions, whose publication in the scientific literature and in the wider media has caused damage to the credibility of science and researchers in the field. We and many others have criticized t...
Source: Transgenic Research - February 22, 2013 Category: Genetics & Stem Cells Authors: Arjó G, Portero M, Piñol C, Viñas J, Matias-Guiu X, Capell T, Bartholomaeus A, Parrott W, Christou P Tags: Transgenic Res Source Type: research

Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway
EMBO Reports. doi:10.1038/embor.2013.16 Authors: Irmina Diala, Nicole Wagner, Frédérique Magdinier, Marina Shkreli, Maria Sirakov, Serge Bauwens, Caroline Schluth-Bolard, Thomas Simonet, Valérie M Renault, Jing Ye, Abdelnnadir Djerbi, Pascal Pineau, Jinkuk Choi, Steven Artandi, Anne Dejean, Michelina Plateroti & Eric Gilson
Source: EMBO Reports AOP - February 22, 2013 Category: Research Authors: Irmina DialaNicole WagnerFrédérique MagdinierMarina ShkreliMaria SirakovSerge BauwensCaroline Schluth-BolardThomas SimonetValérie M RenaultJing YeAbdelnnadir DjerbiPascal PineauJinkuk ChoiSteven ArtandiAnne DejeanMichelina PlaterotiEric Gilson Tags: telomere TRF2 Wnt signalling cancer Scientific Report Source Type: research

Utility of Preoperative Ultrasound for Predicting pN2 or Higher Stage Axillary Lymph Node Involvement in Patients With Newly Diagnosed Breast Cancer
CONCLUSION. Ultrasound was useful for predicting pN2 or higher axillary disease in breast cancer patients. Preoperative ultrasound assessment for staging of axillary lymph nodes might help avoid underestimation at sentinel lymph node biopsy.
Source: American Journal of Roentgenology - February 22, 2013 Category: Radiology Authors: Abe, H., Schacht, D., Sennett, C. A., Newstead, G. M., Schmidt, R. A. Tags: Women ' s Imaging Source Type: research

Invasive Micropapillary Carcinoma of the Breast: Imaging Features With Clinical and Pathologic Correlation
CONCLUSION. The imaging features of invasive ductal carcinoma of the breast with micropapillary features typically were highly suggestive of malignancy. The malignancies were strongly associated with lymphovascular invasion and lymph node metastases. Radiologists should be aware of the imaging features of this unusual variant and should consider axillary sonography if this entity is found in a core needle biopsy specimen.
Source: American Journal of Roentgenology - February 22, 2013 Category: Radiology Authors: Jones, K. N., Guimaraes, L. S., Reynolds, C. A., Ghosh, K., Degnim, A. C., Glazebrook, K. N. Tags: Women ' s Imaging Source Type: research

Flat Ductal Intraepithelial Neoplasia 1A Diagnosed at Stereotactic Core Needle Biopsy: Is Excisional Biopsy Indicated?
CONCLUSION. The upgrade rate of DIN 1A diagnosed at CNB or VAB was 4.2%. These results indicate it may be reasonable to avert immediate surgery in favor of short-term imaging follow-up.
Source: American Journal of Roentgenology - February 22, 2013 Category: Radiology Authors: Becker, A. K., Gordon, P. B., Harrison, D. A., Hassell, P. R., Hayes, M. M., van Niekerk, D., Wilson, C. M. Tags: Women ' s Imaging Source Type: research

Factors Influencing Local Tumor Control in Patients With Neoplastic Pulmonary Nodules Treated With Microwave Ablation: A Risk-Factor Analysis
CONCLUSION. The independent predictive factors for local tumor progression in primary and secondary lung neoplasms up to 3 cm in diameter observed in this study were irregular shape of the index tumor and energy application of less than 26.7 J/mm3 to the index tumor.
Source: American Journal of Roentgenology - February 22, 2013 Category: Radiology Authors: Vogl, T. J., Worst, T. S., Naguib, N. N. N., Ackermann, H., Gruber-Rouh, T., Nour-Eldin, N.-E. A. Tags: Vascular and Interventional Radiology Source Type: research

PET-Based Primary Tumor Volumetric Parameters and Survival of Patients With Non-Small Cell Lung Carcinoma
CONCLUSION. PET-based volumetric imaging parameters are potential prognostic markers of outcome in patients with NSCLC.
Source: American Journal of Roentgenology - February 22, 2013 Category: Radiology Authors: Davison, J., Mercier, G., Russo, G., Subramaniam, R. M. Tags: Nuclear Medicine and Molecular Imaging Source Type: research

ADC Values and Prognosis of Malignant Astrocytomas: Does Lower ADC Predict a Worse Prognosis Independent of Grade of Tumor?--A Meta-Analysis
CONCLUSION. Low ADC values correlate with poor survival in malignant astrocytomas independent of tumor grade.
Source: American Journal of Roentgenology - February 22, 2013 Category: Radiology Authors: Zulfiqar, M., Yousem, D. M., Lai, H. Tags: Neuroradiology/Head and Neck Imaging Source Type: research

A Clinically Useful Classification of Traumatic Intervertebral Disk Lesions
CONCLUSION. This novel classification may improve communication between spine surgeons and radiologists as well as facilitate clinical decision making in spine surgery. Further studies need to be conducted to verify clinical relevance.
Source: American Journal of Roentgenology - February 22, 2013 Category: Radiology Authors: Sander, A. L., Laurer, H., Lehnert, T., El Saman, A., Eichler, K., Vogl, T. J., Marzi, I. Tags: Musculoskeletal Imaging Source Type: research

Dynamic Contrast-Enhanced Subtraction MRI for Characterizing Intratesticular Mass Lesions
CONCLUSION. Dynamic contrast-enhanced MRI may be used to distinguish between benign and malignant intratesticular mass lesions.
Source: American Journal of Roentgenology - February 22, 2013 Category: Radiology Authors: Tsili, A. C., Argyropoulou, M. I., Astrakas, L. G., Ntoulia, E. A., Giannakis, D., Sofikitis, N., Tsampoulas, K. Tags: Genitourinary Imaging Source Type: research

Pretreatment Microbubble-Induced Enhancement in Hepatocellular Carcinoma Predicts Intrahepatic Distant Recurrence After Radiofrequency Ablation
CONCLUSION. HCC lesions with gradual enhancement in the early arterial time displayed potential distant recurrence risk after RFA, requiring careful posttreatment surveillance.
Source: American Journal of Roentgenology - February 22, 2013 Category: Radiology Authors: Maruyama, H., Takahashi, M., Shimada, T., Sekimoto, T., Kamesaki, H., Kanai, F., Yokosuka, O. Tags: Gastrointestinal Imaging Source Type: research

Histopathologic Findings of Multifocal Pancreatic Intraductal Papillary Mucinous Neoplasms on CT
CONCLUSION. The presence of multiple pancreatic cysts should be looked on with suspicion, particularly when there are a large number of cysts, even when none of the cysts individually meet the imaging criteria for resection according to the Sendai consensus recommendations. At the very least, these patients need to be followed very closely.
Source: American Journal of Roentgenology - February 22, 2013 Category: Radiology Authors: Raman, S. P., Kawamoto, S., Blackford, A., Hruban, R. H., O'Brien-Lennon, A. M., Wolfgang, C. L., Rezaee, N., Edil, B., Fishman, E. K. Tags: Gastrointestinal Imaging Source Type: research

Predictors of Dysplastic Nodule Diagnosis in Patients With Liver Cirrhosis on Unenhanced and Gadobenate Dimeglumine-Enhanced MRI With Dynamic and Hepatobiliary Phase
CONCLUSION. The combination of nodule appearance on T2-weighted MRI and nodule enhancement after gadobenate dimeglumine injection may predict dysplastic nodule diagnosis in patients with liver cirrhosis.
Source: American Journal of Roentgenology - February 22, 2013 Category: Radiology Authors: Quaia, E., De Paoli, L., Pizzolato, R., Angileri, R., Pantano, E., Degrassi, F., Ukmar, M., Cova, M. A. Tags: Gastrointestinal Imaging Source Type: research

Reduced Radiation Exposure of the Female Breast During Low-Dose Chest CT Using Organ-Based Tube Current Modulation and a Bismuth Shield: Comparison of Image Quality and Radiation Dose
CONCLUSION. The radiation dose in the female breast may be reduced using a breast shield or organ-based tube current modulation during low-dose chest CT with acceptable image quality. The use of organ-based tube current modulation reduced the radiation dose in the breast without inducing image quality deterioration.
Source: American Journal of Roentgenology - February 22, 2013 Category: Radiology Authors: Kim, Y. K., Sung, Y. M., Choi, J. H., Kim, E. Y., Kim, H. S. Tags: FOCUS ON: Cardiopulmonary Imaging Source Type: research

Comparison of Four Prediction Models to Discriminate Benign From Malignant Vertebral Compression Fractures According to MRI Feature Analysis
CONCLUSION. It is possible to estimate the malignancy risk of VCF by using a small number of MRI features and patient age. The diagnostic performance of models selected by logistic regression, support vector machine, neural network, and classification tree was similar.
Source: American Journal of Roentgenology - February 22, 2013 Category: Radiology Authors: Thawait, S. K., Kim, J., Klufas, R. A., Morrison, W. B., Flanders, A. E., Carrino, J. A., Ohno-Machado, L. Tags: Special Articles Source Type: research