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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 36.

Meat intake, cooking methods, and risk of proximal colon, distal colon, and rectal cancer: The Norwegian Women and Cancer (NOWAC) cohort study
Abstract Red and processed meat intake is an established risk factor for colorectal cancer (CRC), but epidemiological evidence by subsite and sex are still limited. In the population‐based Norwegian Women and Cancer cohort (NOWAC) we examined associations of meat intake with incident proximal colon, distal colon, and rectal cancer, in 84 538 women who completed a validated food frequency questionnaire (FFQ) during 1996‐1998 or 2003‐2005 (baseline or exposure update) at age 41‐70 years, with follow‐up by register linkages through 2009. We also examined the effect of meat cooking methods in a subsample (n=43 636). ...
Source: International Journal of Cancer - February 9, 2013 Category: Cancer & Oncology Authors: Christine L. Parr, Anette Hjartåker, Eiliv Lund, Marit B. Veierød Tags: Epidemiology Source Type: research

Are We Treaters, Passers, or Doctors?
As often as not, the decision whether to treat or deny treatment to any elderly patient with cancer is a result of an oncologist’s impression of the individual person’s ability to benefit from and withstand the side effects of therapy. And that decision is usually based on a clinical assessment that is far more intuitive than it is scientific.
Source: Cancer Network - February 9, 2013 Category: Cancer & Oncology Source Type: news

Red tape holding back clinical trials
A system of overbearing regulation is preventing researchers from running clinical trials which could lead to new treatments for diseases like cancer, leading experts claim.
Source: Telegraph Health - February 9, 2013 Category: Consumer Health News Source Type: news

New Approach Mimicking The Body's Natural Defenses Could Help Treat A Therapy-Resistant Breast Cancer
Cancer drugs of the new, molecular generation destroy malignant breast tumors in a targeted manner: They block characteristic molecules on tumor cells - receptors for the hormones estrogen or progesterone, or a co-receptor, called HER2, that binds to many growth factors. But about one in every six breast tumors has none of these receptors. Such cancers, called triple-negative, are particularly aggressive and notoriously difficult to treat...
Source: Health News from Medical News Today - February 9, 2013 Category: Consumer Health News Tags: Breast Cancer Source Type: news

Possible Link Between Obesity And Gum Disease
Impacting approximately one-third of the U.S. population, obesity is a significant health concern for Americans. It's a risk factor for developing type 2 diabetes, heart disease, and certain forms of cancer, and now, according to an article published in the January/February 2013 issue of General Dentistry, the peer-reviewed clinical journal of the Academy of General Dentistry (AGD), it also may be a risk factor for gum disease. "We know that being overweight can affect many aspects of a person's health," says Charlene Krejci, DDS, MSD, lead author of the article...
Source: Health News from Medical News Today - February 9, 2013 Category: Consumer Health News Tags: Obesity / Weight Loss / Fitness Source Type: news

Lymphoma Cells Selectively Destroyed By Experimental Drug Combination
Laboratory experiments conducted by scientists at Virginia Commonwealth University Massey Cancer Center suggest that a novel combination of the drugs ibrutinib and bortezomib could potentially be an effective new therapy for several forms of blood cancer, including diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL). The study, published in the British Journal of Hematology, showed that the experimental drug combination killed cancer cells through a form of cell suicide known as apoptosis, but was relatively non-toxic to normal, healthy cells...
Source: Health News from Medical News Today - February 9, 2013 Category: Consumer Health News Tags: Lymphoma / Leukemia / Myeloma Source Type: news

Ghana: Much-Needed Relief for Cancer Patients
[Ghanaian Chronicle]Relatives and friends of Ghanaians living with cancer can now look to the future with tangible hope - hope of saving the lives of ailing loved ones and escaping the double jeopardy of creeping poverty.
Source: AllAfrica News: Health and Medicine - February 9, 2013 Category: African Health Source Type: news

Exelixis execs win bonuses, pay boosts as first cancer drug hits market
Exelixis Inc.'s top five executives will collect more than $1.1 million in bonuses for 2012 — a year in which the 20-year-old company won its first drug approval — and base salary raises for 2013. The money, to be paid out in March, is on top of $234,000 in bonuses collectively awarded in December to President and CEO Michael Morrissey, CFO Frank Karbe, Chief Medical Officer Dr. Gisela Schwab, Chief Commercial Officer J. Scott Garland and general counsel Pamela Simonton. That round of bonus…
Source: bizjournals.com Health Care:Hospitals headlines - February 9, 2013 Category: Hospital Management Authors: Ron Leuty Source Type: research

America, land of the 'quick fix' culture
Think you might someday get breast cancer? There's a quick fix for that: Chop 'em off! It's called a "preventive double mastectomy" and surgeons are right now successfully convincing women who don't even have breast cancer to have both their breasts surgically removed...
Source: NaturalNews.com - February 9, 2013 Category: Consumer Health Advice Source Type: news

Lower your breast cancer risk with fruits and vegetables high in carotenoids
Women with high blood levels of the naturally occurring plant chemicals known as carotenoids have significantly lower risk of breast cancer, according to a study conducted by researchers from Brigham & Women's Hospital and Harvard Medical School and published in the...
Source: NaturalNews.com - February 9, 2013 Category: Consumer Health Advice Source Type: news

How eating a high fat diet can starve cancer
What does it take to disabuse the majority of food consumers that a no or low fat diet is actually unhealthy. There have been conventional cardiologists who've recently asserted that we need healthy fats to maintain good cardiovascular health. They have debunked the...
Source: NaturalNews.com - February 9, 2013 Category: Consumer Health Advice Source Type: news

Deep fried foods increase risk of developing aggressive prostate cancer by one-third
Prostate cancer will affect one in six men during the course of their lifetime, as nearly a quarter of a million new cases are diagnosed in the U.S. each year. While many cases of the disease remain localized as a growing number of patients adopt a wait and see attitude...
Source: NaturalNews.com - February 9, 2013 Category: Consumer Health Advice Source Type: news

Breast cancer survivors complain of drug side effects, consider stopping treatment
Breast cancer survivors in online message boards complain regularly about the side effects associated with post-treatment (adjuvant) therapies, and often confess that they are considering ceasing their treatment, according to a study conducted by researchers from the...
Source: NaturalNews.com - February 9, 2013 Category: Consumer Health Advice Source Type: news

Sleep essential for healthy living: Get your 7 hours a night
For cancer survivors, the benefits of sleep shouldn't be overlooked. Getting enough sleep can help your body respond better to treatment and may speed your recovery.
Source: MayoClinic.com Full Feed - February 9, 2013 Category: Consumer Health News Source Type: news

Down-Regulation of Dual-Specificity Phosphatase 5 in Gastric Cancer by Promoter CpG Island Hypermethylation and Its Potential Role in Carcinogenesis.
Abstract Dual-specificity phosphatase 5 (DUSP5), which regulates the duration and magnitude of ERK1/2 phosphoactivation within the mitogen-activated protein kinase (MAPK) cascade, has recently been proposed to be a tumor suppressor. However, the epigenetic regulation of DUSP5 and its critical roles in gastric cancer (GC) remain unknown. We compared differential RNA expression profiles of GC cell lines with or without treatment with the DNA demethylating agent 5-aza-2'-deoxycytidine. DUSP5 expression was dramatically decreased by DNA methylation. Hypermethylation of the DUSP5 promoter was detected in GC tissue sampl...
Source: The American Journal of Pathology - February 9, 2013 Category: Pathology Authors: Shin SH, Park SY, Kang GH Tags: Am J Pathol Source Type: research

Antofine-induced connexin43 gap junction disassembly in rat astrocytes involves protein kinase Cβ
In this study, we demonstrated that treatment of rat primary astrocytes with antofine induced dose-dependent inhibition of gap junction intercellular communication (GJIC), as assessed by scrape-loading 6-carboxyfluorescein dye transfer. Levels of Cx43 protein were also decreased in a dose- and time-dependent manner following antofine treatment. Double-labeling immunofluorescence microscopy showed that antofine (10ng/ml) induced endocytosis of surface gap junctions into the cytoplasm, where Cx43 was co-localized with the early endosome marker EEA1. Inhibition of lysosomes or proteasomes by co-treatment with antofine and the...
Source: Neurotoxicology - February 9, 2013 Category: Neurology Authors: Huang YF, Liao CK, Lin JC, Jow GM, Wang HS, Wu JC Tags: Neurotoxicology Source Type: research

ICD-9 tobacco use codes are effective identifiers of smoking status.
CONCLUSIONS: Researchers should not be deterred by the unavailability of full-text records to determine smoking status if they have ICD-9 code histories. PMID: 23396545 [PubMed - as supplied by publisher]
Source: Journal of the American Medical Informatics Association - February 9, 2013 Category: Information Technology Authors: Wiley LK, Shah A, Xu H, Bush WS Tags: J Am Med Inform Assoc Source Type: research

Guest editorial: Genetic and epigenetic alterations in hematopoietic malignancies.
PMID: 23397211 [PubMed - as supplied by publisher]
Source: International Journal of Hematology - February 9, 2013 Category: Hematology Authors: Kitamura T Tags: Int J Hematol Source Type: research

Spray-dried casein-based micelles as a vehicle for solubilization and controlled delivery of flutamide: Formulation, characterization, and in vivo pharmacokinetics.
Abstract Novel casein (CAS)-based micelles loaded with the poorly soluble anti-cancer drug, flutamide (FLT), were successfully developed in a powdered form via spray-drying technique. Genipin (GNP) was used to crosslink CAS micelles as demonstrated by color variation of the micelles. Drug solubilization was enhanced by incorporation within the hydrophobic micellar core which was confirmed by solubility study and UV spectra. Spherical core-shell micelles were obtained with a particle size below 100nm and zeta potential around -30mV. At low drug loading, FLT was totally incorporated within micellar core as revealed b...
Source: European Journal of Pharmaceutics and Biopharmaceutics - February 9, 2013 Category: Drugs & Pharmacology Authors: Elzoghby AO, Helmy MW, Samy WM, Elgindy NA Tags: Eur J Pharm Biopharm Source Type: research

Combination of a novel HDAC inhibitor OBP-801/YM753 and a PI3K inhibitor LY294002 synergistically induces apoptosis in human endometrial carcinoma cells due to increase of Bim with accumulation of ROS.
CONCLUSIONS: The combination of OBP-801/YM753 and LY294002 is effective on inhibition of the growth of HEC-1A cells, and we suggest that this combination is promising a novel therapeutic strategy for endometrial carcinoma. PMID: 23403163 [PubMed - as supplied by publisher]
Source: Gynecologic Oncology - February 9, 2013 Category: Cancer & Oncology Authors: Yoshioka T, Yogosawa S, Yamada T, Kitawaki J, Sakai T Tags: Gynecol Oncol Source Type: research

Patterns of chemotherapy treatment for women with invasive epithelial ovarian cancer - a population-based study.
CONCLUSIONS: For specific patient groups, particularly older women, there is notable variation from standard treatment. Understanding how treatment variations affect survival and determining optimal regimens for these groups are research priorities. PMID: 23403164 [PubMed - as supplied by publisher]
Source: Gynecologic Oncology - February 9, 2013 Category: Cancer & Oncology Authors: Jordan S, Steer C, Defazio A, Quinn M, Obermair A, Friedlander M, Francis J, O'Brien S, Goss G, Wyld D, Australian Ovarian Cancer Study Group, Webb P, for the Ovarian Cancer Patterns of Care Study Group Tags: Gynecol Oncol Source Type: research

Adenovirus-mediated Interferon-γ Gene Therapy Induced Human Pancreatic Carcinoma Capan-2 Cell Apoptosis In Vitro and In Vivo.
In this study, we examined the potential therapeutic effects of an adenovirus encoding human interferon gamma (Ad-IFNγ) on pancreatic carcinoma cells Capan-2 in vitro and in vivo. The results indicated that Ad-IFNγ could significantly inhibit tumor cell growth via inducing cell apoptosis. After infection, IFNγ expressed durably and stably in xenografts, predominantly in tumor tissue, while much less in blood and liver. Thus, adenovirus-mediated intratumoral injection of human IFNγ gene could be an effective gene therapeutic system for the treatment of pancreatic carcinoma. Anat Rec, 00:000-000, 2013. © 2013 Wiley Peri...
Source: Anatomical Record - February 9, 2013 Category: Anatomy Authors: Xie FJ, Zhao P, Zhang YP, Liu FY, Nie XL, Zhu YH, Yu XM, Zheng QQ, Mao WM, Lu HY, Wei H, Huang W Tags: Anat Rec (Hoboken) Source Type: research

In MMTV-Her-2/neu transgenic mammary tumors the absence of caveolin-1(-/-) alters PTEN and NHERF1 but not β-catenin expression.
Abstract In a recent study, we have shown that in mammary tumors from mice lacking the Cav-1 gene, there are alterations in specific heat shock proteins as well as in tumor development. With this in mind, we have now investigated other proteins in the same mammary mouse tumor model (Her-2/neu expressing mammary tumors from Cav-1 wild type and Cav-1 null mice), to further comprehend the complex tumor-stroma mechanisms involved in regulating stress responses during tumor development. In this tumor model the cancer cells always lacked of Cav-1, so the KO influenced the Cav-1 in the stroma. By immunohistochemistry, we ...
Source: Cell Stress and Chaperones - February 9, 2013 Category: Cytology Authors: Cuello-Carrión FD, Cayado-Gutiérrez N, Natoli AL, Restall C, Anderson RL, Nadin S, Alvarez-Olmedo D, Castro GN, Gago FE, Fanelli MA, Ciocca DR Tags: Cell Stress Chaperones Source Type: research

Identification of the general transcription factor Yin Yang 1 as a novel and specific binding partner for S6 Kinase 2.
In this study, we report for the first time, the identification of the general transcription factor Yin Yang 1 (YY1) as a novel and specific binding partner of S6K2, but not S6K1. The interaction between YY1 and S6K2 was demonstrated by co-immunoprecipitation of transiently overexpressed and endogenous proteins in a number of cell lines, including HEK293, MCF7 and U937. Furthermore, direct association between S6K2 and YY1 was demonstrated by GST pull-down assay using recombinant proteins. A panel of deletion mutants was used to show that the C-terminal regulatory region of S6K2 mediates the interaction with YY1. Interestin...
Source: Cellular Signalling - February 9, 2013 Category: Cytology Authors: Ismail HH, Myronova O, Tsuchiya Y, Niewiarowski A, Tsaneva I, Gout I Tags: Cell Signal Source Type: research

Geographical Distribution Of Slovenian Brca1/2 Families According To Family Origin: Implications For Genetic Screening.
Abstract Knowledge of the geographical distribution of highly recurrent mutations may be useful for efficient screening in cancer families. Since the cloning of the BRCA1/2 genes it is known that the wide spectrum of deleterious mutations show high ethnic and geographic heterogeneity. In the present work we have tested probands from 582 breast/ovarian cancer families and positioned all 156 BRCA1/2 families on the map according to the family origin. We observed that high risk families with the same recurrent mutation present a typical geographical distribution and that different recurrent mutations may show differen...
Source: Clinical Genetics - February 9, 2013 Category: Genetics & Stem Cells Authors: Krajc M, Zadnik V, Novaković S, Stegel V, Teugels E, Bešič N, Hočevar M, Vakselj A, De Grève J, Zgajnar J Tags: Clin Genet Source Type: research

Ovarian metastasis from adenocarcinoma of the lung.
Abstract A case of a young woman, affected by an unresectable pulmonary adenocarcinoma, diagnosed by broncoscopy with biopsies and treated with platinum-pemetrexed based chemotherapy, with an incidental finding of a left ovarian mass. At ultrasound examination, a solid lesion was detected in the left ovary. Final pathology revealed an ovarian metastasis from low differentiate adenocarcinoma of the lung. This experience gives us an example of an ovarian metastasis from lung cancer, which at ultrasound examination appears as solid ovarian mass, with lobulated margins, moderate vascularisation, adjacent to normal ovar...
Source: The Ultrasound Review of Obstetrics and Gynecology - February 9, 2013 Category: Radiology Authors: Testa AC, De Blasis I, Di Legge A, Scambia G Tags: Ultrasound Obstet Gynecol Source Type: research

Expression Pattern of Id Proteins in Medulloblastoma.
This study shows that Id1 expression in endothelial cells may contribute to angiogenic processes and that increased expression of Id2 and Id3 in medulloblastoma is potentially involved in tumor cell proliferation and survival. PMID: 23397264 [PubMed - as supplied by publisher]
Source: Pathology Oncology Research - February 9, 2013 Category: Pathology Authors: Snyder AD, Dulin-Smith AN, Houston RH, Durban AN, Brisbin BJ, Oostra TD, Marshall JT, Kahwash BM, Pierson CR Tags: Pathol Oncol Res Source Type: research

Immunohistochemical expression of core2 β1‐6 N‐acetylglucosaminyl transferase 1 (C2GnT1) in endometrioid type of endometrial carcinoma: a novel potential prognostic factor
ConclusionsC2GnT1 appears to be involved in the biological aggressiveness of endometrial carcinoma. C2GnT1 might become a novel prognostic factor of endometrial carcinoma.© 2013 Blackwell Publishing Ltd
Source: Histopathology - February 9, 2013 Category: Pathology Authors: Tsutomu Miyamoto, Akihisa Suzuki, Ryoichi Asaka, Kaori Ishikawa, Yasushi Yamada, Hisanori Kobara, Jun Nakayama, Tanri Shiozawa Tags: Original Article Source Type: research

Lipomatous Lesions of the Parotid Gland
ConclusionsWe present the largest series, to our knowledge, of lipomatous lesions of the parotid gland. These masses, although rare, should be considered in the evaluation of a parotid mass. This series provides insight into the clinical presentation, diagnostic evaluation, and surgical treatment of parotid lipomatous lesions. Surgical extent depends on lesion location in the gland. Lipomatous masses can be effectively treated surgically with low morbidity and high cure rates. Level of Evidence4
Source: The Laryngoscope - February 9, 2013 Category: ENT & OMF Authors: Sidney J. Starkman, Steven M. Olsen, Jean E. Lewis, Kerry D. Olsen, Alain Sabri Tags: Head and Neck Source Type: research

Latissimus Dorsi Muscle Free Flap Revisited
ConclusionsEndoscope‐assisted LD muscle free flap is a feasible and practical option for the reconstruction of selective oral cavity defects with aesthetically excellent donor site scar. Laryngoscope, 2012 Level of Evidence4
Source: The Laryngoscope - February 9, 2013 Category: ENT & OMF Authors: Wonjae Cha, Woo‐Jin Jeong, Soon‐Hyun Ahn Tags: Head and Neck Source Type: research

Frozen margin analysis as a prognosis predictor in early glottic cancer by laser cordectomy
ConclusionsIn endoscopic resection of early glottic cancer with the CO2 laser, initial intraoperative frozen section margin involvement during the primary resection and early local recurrence are poor signs for overall survival. Level of Evidence4.
Source: The Laryngoscope - February 9, 2013 Category: ENT & OMF Authors: Tuan‐Jen Fang, Mark S. Courey, Chun‐Ta Liao, Tsu‐Chen Yen, Hsueh‐Yu Li Tags: Laryngology Source Type: research

A Faith‐ and Community‐Based Approach to Identifying the Individual at Risk for Head and Neck Cancer in an Inner City
ConclusionsInhabitants of homeless shelters represent a particularly vulnerable population for both the development and poor prognosis of head and neck cancer. Members of urban church groups are also an at‐risk subpopulation due to the prevalence of poor prognostic risk factors. These groups may benefit from future targeted screenings for head and neck cancer. Level of Evidence2 b
Source: The Laryngoscope - February 9, 2013 Category: ENT & OMF Authors: John M. Carter, Ryan D. Winters, Rosa Lipin, Sara Lookabaugh, David Cai, Paul L. Friedlander Tags: Head and Neck Source Type: research

Microenvironment generated during EGFR targeted killing of pancreatic tumor cells by ATC inhibits myeloid-derived suppressor cells through COX2 and PGE2 dependent pathway
In this study, we investigated the mechanism(s) of bispecific antibody armed ATC mediated inhibition of MDSC in the presence or absence of Th1 microenvironment. Methods: We used 3D co-culture model of peripheral blood mononuclear cells (PBMC) with pancreatic cancer cells MiaPaCa-2 [MiaE] and gemcitabine resistant MiaPaCa-GR [MiaM] cells to generate MDSC in the presence or absence of Th1 cytokines and EGFRBi armed ATC (aATC). Results: We show significantly decreased differentiation of MDSC (MiaE, p
Source: Journal of Translational Medicine - February 9, 2013 Category: Research Authors: Archana ThakurDana SchalkElyse TomaszewskiSri KondadasulaHiroshi YanoFazlul SarkarLawrence Lum Source Type: research

Heparanase enzyme in inflammation and inflammation‐associated cancer
Abstract Recent years have seen a growing body of evidence that enzymatic remodeling of heparan sulfate proteoglycans profoundly affects a variety of physiological and pathological processes, including inflammation, neovasvularization and tumor development. Heparanase is the sole mammalian endoglycosidase that cleaves heparan sulfate. Extensively studied in cancer progression and aggressiveness, heparanase enzyme was recently implicated in several inflammatory disorders as well. Although the precise mode of heparanase action in inflammatory reactions is still not completely understood, the fact that heparanase activity is ...
Source: FEBS Journal - February 9, 2013 Category: Research Authors: Amichay Meirovitz, Rachel Goldberg, Adi Binder, Ariel M. Rubinstein, Esther Hermano, Michael Elkin Tags: Review Article Source Type: research

Upregulated H19 contributes to bladder cancer cell proliferation by regulating ID2 expression
Conclusions: Upregulated H19 increases bladder cancer growth by regulating ID2 expression, and thus may be helpful in the development of effective treatment strategies against bladder cancer. © 2013 The Authors Journal compilation © 2013 FEBS
Source: FEBS Journal - February 9, 2013 Category: Research Authors: Ming Luo, Zuowei Li, Wei Wang, Yigang Zeng, Zhihong Liu, Jianxin Qiu Tags: Original Article Source Type: research

Handling Rude People
During treatment for breast cancer, you may get rude comments or insensitive remarks about yourself or the disease. Many people have never dealt with cancer, and have no idea of what to say. But if they are rude, you can decide how to respond. Learn the reasons that people may blurt out hurtful remarks.
Source: About.com Breast Cancer - February 9, 2013 Category: Cancer & Oncology Authors: breastcancer.guide at about.com Tags: health Source Type: news

10 Snappy Comebacks
You've got breast cancer, and now you've got rude people asking embarrassing questions and making thoughtless comments. How do you respond? Here's 10 snappy comebacks for those times that you need one.
Source: About.com Breast Cancer - February 9, 2013 Category: Cancer & Oncology Authors: breastcancer.guide at about.com Tags: health Source Type: news

Epigenetic change in kidney tumor: downregulation of histone acetyltransferase MYST1 in human renal cell carcinoma
Conclusion: hMOF as an acetyltransferase of H4K16 might be involved in the pathogenesis of kidney cancer, and this epigenetic changes might be a new CA9-independent RCC diagnostic maker.
Source: Journal of Experimental and Clinical Cancer Research - February 9, 2013 Category: Cancer & Oncology Authors: Yong WangRui ZhangDonglu WuZhihua LuWentao SunYong CaiChunxi WangJingji Jin Source Type: research

Antiproliferative activity and apoptosis-inducing mechanism of constituents from Toona sinensis on human cancer cells
Conclusions: The study shows that most of the compounds obtained from Toona sinensis could inhibit the growth of human cancer cells. Furthermore, BTA and OEA exhibited potent antitumor activities via induction of cancer cell apoptosis.
Source: Cancer Cell International - February 9, 2013 Category: Cancer & Oncology Authors: Shengjie YangQi ZhaoHongmei XiangMinjie LiuQiuyun ZhangWei XueBaoan SongSong Yang Source Type: research

Adenovirus‐mediated Interferon‐γ Gene Therapy Induced Human Pancreatic Carcinoma Capan‐2 Cell Apoptosis In Vitro and In Vivo
In this study, we examined the potential therapeutic effects of an adenovirus encoding human interferon gamma (Ad‐IFNγ) on pancreatic carcinoma cells Capan‐2 in vitro and in vivo. The results indicated that Ad‐IFNγ could significantly inhibit tumor cell growth via inducing cell apoptosis. After infection, IFNγ expressed durably and stably in xenografts, predominantly in tumor tissue, while much less in blood and liver. Thus, adenovirus‐mediated intratumoral injection of human IFNγ gene could be an effective gene therapeutic system for the treatment of pancreatic carcinoma. Anat Rec, 00:000–000, 2013. © 2013 ...
Source: The Anatomical Record Part B: The New Anatomist - February 9, 2013 Category: Anatomy Authors: Fa‐Jun Xie, Peng Zhao, Yi‐Ping Zhang, Fei‐Ye Liu, Xi‐Lin Nie, Ying‐Hui Zhu, Xin‐Min Yu, Qiu‐Qing Zheng, Wei‐Min Mao, Hong‐Yang Lu, Hong Wei, WenLin Huang Tags: Full Length Article Source Type: research

Becoming patient: a path to effective participation with chronic terminal cancer.
Abstract One chronic terminal lung cancer patient was purposely selected. My grounded theory findings indicated that this middle-aged, asymptomatic, otherwise healthy woman used the basic social process of asking, "How can I participate in treatment?" in order to resolve a crisis of pain. Participation involved the overarching condition of trust in medical personnel, and included seven overlapping considerations: expense, disease progress, bodily feeling, explanations, plans, emotional reactions, and turning point. The findings provide information that may lead to smoother transitions to changing the status of a pa...
Source: Pain Physician - February 8, 2013 Category: Anesthesiology Authors: Katzman S Tags: Health Care Women Int Source Type: research

Exelixis execs win bonuses, pay boosts as first cancer drug hits market
Exelixis Inc.'s top five executives will collect more than $1.1 million in bonuses for 2012 — a year in which the 20-year-old company won its first drug approval — and base salary raises for 2013. The money, to be paid out in March, is on top of $234,000 in bonuses collectively awarded in December to President and CEO Michael Morrissey, CFO Frank Karbe, Chief Medical Officer Dr. Gisela Schwab, Chief Commercial Officer J. Scott Garland and general counsel Pamela Simonton. That round of bonus…
Source: bizjournals.com Health Care:Biotechnology headlines - February 8, 2013 Category: Biotechnology Authors: Ron Leuty Source Type: research

Cancer Drug Doesn't Speed Up Tumor Growth, Researchers Say
The anticancer drug Sutent (sunitinib) does not cause tumors to grow faster after treatment ends, according to a new study.02/08/2013
Source: Kidney Cancer Association - February 8, 2013 Category: Cancer & Oncology Source Type: news

Normal viability of Kai1/Cd82 deficient mice
Abstract The KAI1/CD82 tetraspanin is a widely expressed cell surface molecule thought to organize diverse cellular signaling processes. KAI1/CD82 suppresses metastasis but not tumorigenicity, establishing it as one of a class of metastasis suppressor genes. In order to further assess its functions, we have characterized the phenotypic properties of Kai1/Cd82 deleted mice, including viability, fertility, lymphocyte composition, blood chemistry and tissue histopathology, and of their wild‐type and heterozygote littermates. Interestingly, Kai1/Cd82−/− showed no obvious genotype associated defects in any of these proces...
Source: Molecular Carcinogenesis - February 8, 2013 Category: Molecular Biology Authors: John I. Risinger, Mary Custer, Lionel Feigenbaum, R. Mark Simpson, Shelley B. Hoover, Joshua D. Webster, Gadisetti V. R. Chandramouli, Lino Tessarollo, J. Carl Barrett Tags: Research Article Source Type: research

Racially restricted contribution of immunoglobulin Fcγ and Fcγ receptor genotypes to humoral immunity to human epidermal growth factor receptor 2 in breast cancer.
Abstract Tumour-associated antigen human epidermal growth factor receptor 2 (HER2) is over-expressed in 25-30% of breast cancer patients and is associated with poor prognosis. Naturally occurring anti-HER2 antibody responses have been described in patients with HER2 over-expressing tumours. There is significant interindividual variability in antibody responsiveness, but the host genetic factors responsible for this variability are poorly understood. The aim of the present investigation was to determine whether immunoglobulin genetic markers [GM (genetic determinants of γ chains)] and Fcγ receptor (FcγR) alleles ...
Source: Clinical and Developmental Immunology - February 8, 2013 Category: Allergy & Immunology Authors: Pandey JP, Namboodiri AM, Kistner-Griffin E, Iwasaki M, Kasuga Y, Hamada GS, Tsugane S Tags: Clin Exp Immunol Source Type: research

Imaging biomarkers show promise for cancer treatment response
Imaging biomarkers show promise as tools to assess patient response to chemotherapy (more)
Source: AuntMinnie.com Headlines - February 8, 2013 Category: Radiology Source Type: news

Avastin May Help Boost Survival With Aggressive Cervical Cancer: Study
Women taking the drug lived more than 3 months longer on average, but side effects were an issue
Source: Cancercompass News: Gynecological Cancer - February 8, 2013 Category: Cancer & Oncology Source Type: news

On-the-Job Stress Won't Raise Your Risk for Cancer, Study Finds
But it could lead to behaviors that increase the chances of disease, one expert says
Source: Cancercompass News: Breast Cancer - February 8, 2013 Category: Cancer & Oncology Source Type: news

FDA Approves Pomalidomide for Multiple MyelomaFDA Approves Pomalidomide for Multiple Myeloma
The oral therapy Pomalyst (Celgene) was approved for use in patients who have received at least 2 prior therapies, and whose disease progressed within 60 days of the last treatment. FDA Approvals
Source: Medscape Today Headlines - February 8, 2013 Category: Consumer Health News Tags: Hematology-Oncology News Alert Source Type: news

Zinc (II) Complexes Containing Bis-benzimidazole Derivatives as a New Class of Apoptosis Inducers That Trigger DNA damage-mediated P53 Phosphorylation in Cancer Cells
Dalton Trans., 2013, Accepted ManuscriptDOI: 10.1039/C3DT33077J, PaperShenggui Liu, Wenqiang Cao, Lianling Yu, Wen-Jie Zheng, Linlin Li, Cundong Fan, Tianfeng ChenTwo zinc (II) complexes containing bis-benzimidazole derivatives, Zn(bpbp)Cl2 (1) and [Zn(bpbp)2](ClO4)2CH3CH2OHH2O (2) (bpbp = 2,6-bis(1-phenyl-1H-benzo[d]imidazol-2-yl)pyridine), have been designed, synthesized and evaluated for their in vitro anticancer activities in the present...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - February 8, 2013 Category: Chemistry Authors: Shenggui Liu Source Type: research