Cardiology
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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 16.
Origin of cardiac fibroblasts and the role of periostin.
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Cardiac fibroblasts are the most populous nonmyocyte cell type within the mature heart and are required for extracellular matrix synthesis and deposition, generation of the cardiac skeleton, and to electrically insulate the atria from the ventricles. Significantly, cardiac fibroblasts have also been shown to play an important role in cardiomyocyte growth and expansion of the ventricular chambers during heart development. Although there are currently no cardiac fibroblast-restricted molecular markers, it is generally envisaged that the majority of the cardiac fibroblasts are derived from the proepicardium via epithelial...
Source: Circulation Research - November 6, 2009 Category: Cardiology Authors: Snider P, Standley KN, Wang J, Azhar M, Doetschman T, Conway SJ Tags: Circ Res Source Type: journals
Controlling myocyte cGMP: phosphodiesterase 1 joins the fray.Email this article to a colleague.
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PMID: 19893020 [PubMed - in process]
Source: Circulation Research - November 6, 2009 Category: Cardiology Authors: Takimoto E Tags: Circ Res Source Type: journals
Cell-Based Therapies for Ischemic Heart Disease.Email this article to a colleague.
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Cell therapy is a promising approach to improve cardiac function in patients with ischemic heart disease. Beneficial effects of cell therapy have been shown in experimental studies and clinical trials. However, with current treatment strategies the therapeutic effect is limited. In the current article, critical aspects of cell therapy are discussed: cell type, the state of ischemic heart disease and the condition of cells at the time of treatment. Because treatment options of native cells by systemic pharmacotherapy are limited, we propose a concept of ex vivo preconditioning to overcome functional cell impairment and ...
Source: Circulation Journal - November 6, 2009 Category: Cardiology Authors: Limbourg A, Limbourg F, Drexler H Tags: Circ J Source Type: journals
Medicaid access to smoking cessation falls shortEmail this article to a colleague.
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A national survey shows that although the majority of state Medicaid programs offer coverage for some form of tobacco-dependence treatment, most fall far short of a stated mandate to provide unrestricted access to approved therapies.
Source: theHeart.org - November 5, 2009 Category: Cardiology Source Type: info
Serum phosphorous, kidney function predict CACEmail this article to a colleague.
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The Spokane Heart Study finds a connection between kidney function, serum phosphorus, and the risk of coronary artery calcification.
Source: theHeart.org - November 5, 2009 Category: Cardiology Source Type: info
Volcano Reports 22 Percent Increase in Third Quarter RevenuesEmail this article to a colleague.
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Volcano Corporation (Nasdaq: VOLC) today reported revenues of $53.9 million for the third quarter of fiscal 2009. The results for the quarter ended September 30, 2009, represent an increase of 22 percent over revenues of $44.1 million in the third quarter of 2008.
Source: News from Angioplasty.Org - November 5, 2009 Category: Cardiology Source Type: news
Serum Phosphorus Predicts Coronary Artery Calcification (CME/CE)Email this article to a colleague.
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Coronary artery calcification was common among apparently healthy adults, became more frequent and severe with time, and was associated with elevated levels of serum phosphorus, according to an analysis of data from a long-term population study.
Source: MedPage Today Cardiovascular - November 5, 2009 Category: Cardiology Source Type: news
Episode #13: Pulmonary vasoconstriction in advanced heart failure and new CHF/transplantation certification with Drs Marc...Email this article to a colleague.
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Fellows' corner - Cardiology fellow-conducted interviews of thought leaders on training, research, career planning, and dilemmas encountered by cardiovascular physicians.
Source: The Fellows Corner - November 5, 2009 Category: Cardiology Authors: info at theheart.org Tags: Fellows' corner Source Type: podcasts
Low-cholesterol/cancer studies should "dispel lingering doubts" of causal linkEmail this article to a colleague.
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Two new papers should help put to rest concerns that low serum cholesterol levels may increase cancer risk.
Source: theHeart.org - November 5, 2009 Category: Cardiology Source Type: info
Fines to be issued for trial sites that don’t notify patients of data breachesEmail this article to a colleague.
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Clinical trial sites that do not adhere to the language written in the American Recovery and Reinvestment Act of 2009 requiring facilities to divulge privacy breaches to their patients, could pay up to a $50,000 penalty per violation.
Source: Cardiovascular Business News - November 5, 2009 Category: Cardiology Tags: Latest News Source Type: news
Trial sites to be issued fines if they don’t notify patients of data breachesEmail this article to a colleague.
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Clinical trial sites that do not adhere to the language written in the American Recovery and Reinvestment Act of 2009 requiring facilities to divulge privacy breaches to their patients, could pay up to a $50,000 penalty per violation.
Source: Cardiovascular Business News - November 5, 2009 Category: Cardiology Tags: Latest News Source Type: news
Not all metabolic syndrome is created equal: Framingham Offspring analysisEmail this article to a colleague.
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The syndrome (defined by ATP III criteria) can predict increased cardiovascular and mortality risk or not, depending on which three of five risk factors contributed to the diagnosis, a cohort study suggests; its investigators caution that their observations are only preliminary.
Source: theHeart.org - November 5, 2009 Category: Cardiology Source Type: info
Prehospital triage "immediately successful" in boosting rates of thrombolytic therapy for strokeEmail this article to a colleague.
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Toronto researchers report that a citywide prehospital protocol raised their rates of thrombolytic treatment to among the highest in North America, underlining, they say, the critical importance of organized stroke care.
Source: theHeart.org - November 5, 2009 Category: Cardiology Source Type: info
Feature: CMS cuts could make hospitalists out of cardiologistsEmail this article to a colleague.
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Since the Centers for Medicare & Medicaid Services (CMS) issued its 2010 physician fee final rule last week with cuts to cardiology practices averaging 27 percent, the American College of Cardiology has expressed adamant opposition, and its CEO, Jack Lewin, MD, said that this will cause the shuttering of practices. However, former CMS Administrator Thomas A. Scully explained how the agency is limited by finite funding and growing pressures to fund other areas of healthcare.
Source: Cardiovascular Business News - November 5, 2009 Category: Cardiology Tags: Latest News Source Type: news
Hypertension, arterial disease in middle age contribute to Alzheimer’s diseaseEmail this article to a colleague.
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Hypertension and evidence of arterial disease and a pro-inflammatory status in middle age contribute to the development of Alzheimer’s disease, say researchers.
Source: MedWire News - Cardiology - November 5, 2009 Category: Cardiology Source Type: news
Editorial BoardEmail this article to a colleague.
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Source: The American Journal of Cardiology - November 5, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals
ContentsEmail this article to a colleague.
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Source: The American Journal of Cardiology - November 5, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals
Combined Role of Reduced Estimated Glomerular Filtration Rate and Microalbuminuria on the Prevalence of Peripheral Arterial DiseaseEmail this article to a colleague.
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Chronic kidney disease (CKD), defined by either microalbuminuria (MA) or a reduced estimated glomerular filtration rate (eGFR), is associated with an increased risk of peripheral arterial disease (PAD). The presence of both abnormalities might identify a subgroup of adults at particularly high risk of PAD. Accordingly, we sought to evaluate the combined effect of a reduced eGFR and MA on the prevalence of PAD among United States adults. United States adults ≥40 years old (n = 6,951) participating in the 1999 to 2004 National Health and Nutrition Examination Survey were cross-classified into 4 groups according to the pres...
Source: The American Journal of Cardiology - November 5, 2009 Category: Cardiology Authors: Usman Baber, Devin Mann, Daichi Shimbo, Mark Woodward, Jeffrey W. Olin, Paul Muntner Tags: Miscellaneous Source Type: journals
Optimization of the Interventricular Delay in Cardiac Resynchronization Therapy Using the QRS WidthEmail this article to a colleague.
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Optimization of the interventricular pacing delay (VV) in cardiac resynchronization therapy is time-consuming and not routinely performed. The aim of the present study was to compare the acute hemodynamic response obtained by different VV programming methods. Several methods for optimizing the VV using electrocardiographic or echocardiographic measurements were performed. The effect of programming an empirical prefixed VV of 0 ms was also evaluated. Invasive first derivative of left ventricular (LV) pressure over time (dP/dt max) was measured at several VV values, and the hemodynamic response that could be obtained by each...
Source: The American Journal of Cardiology - November 5, 2009 Category: Cardiology Authors: David Tamborero, Lluís Mont, Marta Sitges, Etelvino Silva, Antonio Berruezo, Barbara Vidal, Victoria Delgado, Jose M. Tolosana, Miguel Godoy, Angeles Castel, Josep Brugada Tags: Heart Failure Source Type: journals
Distribution of Left Ventricular Ejection Fraction in Patients With Ischemic and Hypertensive Heart Disease and Chronic Heart FailureEmail this article to a colleague.
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In conclusion, the observed bimodal distribution of EF in patients with chronic HF is a reflection of 2 HF phenotypes with different underlying pathophysiologic features.
Source: The American Journal of Cardiology - November 5, 2009 Category: Cardiology Authors: William H. Gaasch, Dennis E. Delorey, Fred J. Kueffer, Michael R. Zile Tags: Heart Failure Source Type: journals
Usefulness of Triglycerides-to–High-Density Lipoprotein Cholesterol Ratio for Predicting the First Coronary Event in MenEmail this article to a colleague.
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In conclusion, the TG/HDL ratio has a high predictive value of a first coronary event regardless of BMI.
Source: The American Journal of Cardiology - November 5, 2009 Category: Cardiology Authors: Alberto Cordero, Eva Andrés, Beatriz Ordoñez, Montserrat León, Martín Laclaustra, Alberto Grima, Emilio Luengo, José Moreno, María Bes, Isaac Pascual, Fernando Civeira, Miguel Pocoví, Eduardo Alegría, José A. Casasnovas, MESYAS (MEtabolic Syndrom Tags: Preventive Cardiology Source Type: journals
Comparison of Dual Source Computed Tomography Versus Intravascular Ultrasound for Evaluation of Coronary Arteries at Least One Year After Cardiac TransplantationEmail this article to a colleague.
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In conclusion, DSCT permits the investigation of transplant recipients concerning the presence of CAV with good image quality and high diagnostic accuracy.
Source: The American Journal of Cardiology - November 5, 2009 Category: Cardiology Authors: Tiziano Schepis, Stephan Achenbach, Michael Weyand, Philip Raum, Mohamed Marwan, Tobias Pflederer, Werner G. Daniel, Rene Tandler, Markus Kondruweit, Dieter Ropers Tags: Coronary Artery Disease Source Type: journals
Substrate-Specific Derangements in Mitochondrial Metabolism and Redox Balance in the Atrium of the Type 2 Diabetic Human HeartEmail this article to a colleague.
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Conclusions: These findings are the first to directly investigate the effects of type 2 diabetes on a panoply of mitochondrial functions in the human myocardium using cellular and molecular approaches, and they show that mitochondria in diabetic human hearts have specific impairments in maximal capacity to oxidize fatty acids and glutamate, yet increased mitochondrial H2O2 emission, providing insight into the role of mitochondrial dysfunction and oxidative stress in the pathogenesis of heart failure in diabetic patients.
Source: Journal of the American College of Cardiology - November 5, 2009 Category: Cardiology Authors: Ethan J. Anderson, Alan P. Kypson, Evelio Rodriguez, Curtis A. Anderson, Eric J. Lehr, P. Darrell Neufer Tags: Diabetes and Cardiac Function Source Type: journals
Giant True Saphenous Vein Graft AneurysmEmail this article to a colleague.
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A 60-year-old man who had undergone saphenous vein grafting to the left anterior descending artery 23 years ago complained of continuous resting chest pain for the last 48 h. No electrocardiographic changes were observed, and laboratory tests showed normal troponin T and creatine kinase levels on admittance and at 8, 12, and 24 h later. Coronary angiography was performed and showed chronic total occlusion of the left anterior descending artery and a severely degenerated and occluded saphenous vein graft. Contrast-enhanced computed tomography showed an extracardiac mass of 85 × 51 mm compressing the left atrium, correspond...
Source: Journal of the American College of Cardiology - November 5, 2009 Category: Cardiology Authors: Juan Garcia-Lara, Eduardo Pinar-Bermudez, Jose Antonio Hurtado, Mariano Valdez-Chavarri Tags: IMAGES IN CARDIOLOGY Source Type: journals
The 5-Year Clinical Outcomes After a Randomized Comparison of Sirolimus-Eluting Versus Bare-Metal Stent Implantation in Patients With ST-Segment Elevation Myocardial InfarctionEmail this article to a colleague.
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Because patients with acute ST-segment elevation myocardial infarction (STEMI) were excluded from early randomized trials, only relatively short-term data from large multicenter studies comparing drug-eluting stents (DES) with bare-metal stents (BMS) are currently available. Unambiguous ascertainment of long-term compliance with thienopyridines is problematic in STEMI, which is a matter of serious concern (), and one observational registry suggested higher late (>6 months) unadjusted and adjusted mortality rates in STEMI patients with a DES compared with those with a BMS (). Thus, the use of a DES in STEMI patients still r...
Source: Journal of the American College of Cardiology - November 5, 2009 Category: Cardiology Authors: Matteo Tebaldi, Chiara Arcozzi, Gianluca Campo, Gianfranco Percoco, Roberto Ferrari, Marco Valgimigli, STRATEGY Investigators Tags: Research Correspondence Source Type: journals
CorrectionEmail this article to a colleague.
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Yang Q, Li K, Liu X, et al. Contrast-Enhanced Whole-Heart Coronary Magnetic Resonance Angiography at 3.0-T: A Comparative Study With X-Ray Angiography in a Single Center. J Am Coll Cardiol 2009;54:69–76.
Source: Journal of the American College of Cardiology - November 5, 2009 Category: Cardiology Tags: CORRECTIONS Source Type: journals
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Meyers DG, Neuberger JS, He J. Cardiovascular Effect of Bans on Smoking in Public Places: A Systematic Review and Meta-Analysis. J Am Coll Cardiol 2009;54:1249–55. In this article, the meta-analysis included data from Pueblo, Colorado, which the authors erroneously reported as incidence rate ratio (IRR): 0.30. Actually, the IRR is 0.66 (95% confidence interval [CI]: 0.58 to 0.75). This changes the meta-analysis summary IRR to 0.92 (95% CI: 0.86 to 0.99). The meta-regression of the effect of ban duration also changes. The coefficient of post-ban duration in the meta-regression model is −0.16 (95% CI: −0.20 to −0.11...
Source: Journal of the American College of Cardiology - November 5, 2009 Category: Cardiology Tags: CORRECTIONS Source Type: journals
Inside This IssueEmail this article to a colleague.
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1827 Franz H. Messerli, Gurusher S. Panjrath
Source: Journal of the American College of Cardiology - November 5, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals
Plasma Concentration of Amino-Terminal Pro-Brain Natriuretic Peptide in Chronic Heart Failure: Prediction of Cardiovascular Events and Interaction With the Effects of Rosuvastatin: A Report From CORONA (Controlled Rosuvastatin Multinational Trial in Heart Failure)Email this article to a colleague.
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Conclusions: Patients with heart failure due to ischemic heart disease who have NT-proBNP values
Source: Journal of the American College of Cardiology - November 5, 2009 Category: Cardiology Authors: John G.F. Cleland, John J.V. McMurray, John Kjekshus, Jan H. Cornel, Peter Dunselman, Cândida Fonseca, Åke Hjalmarson, Jerzy Korewicki, Magnus Lindberg, Naresh Ranjith, Dirk J. van Veldhuisen, Finn Waagstein, Hans Wedel, John Wikstrand, CORONA Study Gro Tags: Heart Failure Source Type: journals
Can Natriuretic Peptides Help Identify Heart Failure Patients for Whom Statins Are Beneficial?⁎Email this article to a colleague.
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One of the great success stories in cardiology is the ability of statins to improve the prognosis in patients at risk of a first or subsequent cardiovascular event. This benefit has been shown across a wide spectrum of patient profiles. The efficacy of statin therapy has been challenged only in high-risk patients such as those on dialysis (), older patients with systolic heart failure (), and patients with chronic heart failure of any cause ().
Source: Journal of the American College of Cardiology - November 5, 2009 Category: Cardiology Authors: Lori B. Daniels, Elizabeth Barrett-Connor Tags: Heart Failure: Editorial Comment Source Type: journals
Aortic Valve Replacement: A Prospective Randomized Evaluation of Mechanical Versus Biological Valves in Patients Ages 55 to 70 YearsEmail this article to a colleague.
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Conclusions: At 13 years, patients undergoing aortic valve replacement either with MP or BP valves had a similar survival rate as well the same rate of occurrence of thromboembolism, bleeding, endocarditis, and MAPE, but patients who had undergone aortic valve replacement with BP valves faced a significantly higher risk of valve failure and reoperation.
Source: Journal of the American College of Cardiology - November 5, 2009 Category: Cardiology Authors: Paolo Stassano, Luigi Di Tommaso, Mario Monaco, Francesco Iorio, Paolo Pepino, Nicola Spampinato, Carlo Vosa Tags: Valvular Heart Disease Source Type: journals
Current Selection of Optimal Prosthetic Aortic Valve Replacement in Middle-Aged Patients: Still Dealer's Choice⁎Email this article to a colleague.
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Selection of the type of prosthetic aortic valve replacement (AVR) is frequently a difficult judgment decision affecting the majority of patients who require surgical AVR. The choices generally include bioprosthetic valves (stented or stentless porcine bioprosthesis, stented pericardial prosthesis) and mechanical prosthetic valves (bileaflet or monoleaflet) (). Mechanical valves have the advantage of structural stability but the disadvantage of requiring anticoagulation with warfarin, whereas bioprostheses have the advantage of not requiring anticoagulation with warfarin but the disadvantage of being subject to time-relate...
Source: Journal of the American College of Cardiology - November 5, 2009 Category: Cardiology Authors: Peter H. Stone Tags: Valvular Heart Disease: Editorial Comment Source Type: journals
The Coronary Artery Calcium Score and Stress Myocardial Perfusion Imaging Provide Independent and Complementary Prediction of Cardiac RiskEmail this article to a colleague.
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Conclusions: The CACS and SPECT findings are independent and complementary predictors of short- and long-term cardiac events. Despite a normal SPECT result, a severe CACS identifies subjects at high long-term cardiac risk. After a normal SPECT result, our findings support performing a CACS in patients who are at intermediate or high clinical risk for coronary artery disease to better define those who will have a high long-term risk for adverse cardiac events.
Source: Journal of the American College of Cardiology - November 5, 2009 Category: Cardiology Authors: Su Min Chang, Faisal Nabi, Jiaqiong Xu, Leif E. Peterson, Arup Achari, Craig M. Pratt, John J. Mahmarian Tags: Cardiac Imaging Source Type: journals
Structural Abnormalities of the Pulmonary Trunk in Tetralogy of Fallot and Potential Clinical Implications: A Morphological StudyEmail this article to a colleague.
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Conclusions: Marked histological abnormalities in the PT of hearts with TOF exist compared with controls. These changes were present from infancy and among patients who had undergone palliative or reparative surgery, although operations in this cohort were performed late. Our data suggest that structural abnormalities of the PT, similar to these recently shown in the aorta, are intrinsic.
Source: Journal of the American College of Cardiology - November 5, 2009 Category: Cardiology Authors: Elisabeth Bédard, Karen P. McCarthy, Konstantinos Dimopoulos, Georgios Giannakoulas, Michael A. Gatzoulis, Siew Yen Ho Tags: Congenital Heart Disease Source Type: journals
The J-Curve Between Blood Pressure and Coronary Artery Disease or Essential Hypertension: Exactly How Essential?Email this article to a colleague.
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The topic of the J-curve relationship between blood pressure and coronary artery disease (CAD) has been the subject of much controversy for the past decades. An inverse relationship between diastolic pressure and adverse cardiac ischemic events (i.e., the lower the diastolic pressure the greater the risk of coronary heart disease and adverse outcomes) has been observed in numerous studies. This effect is even more pronounced in patients with underlying CAD. Indeed, a J-shaped relationship between diastolic pressure and coronary events was documented in treated patients with CAD in most large trials that scrutinized this re...
Source: Journal of the American College of Cardiology - November 5, 2009 Category: Cardiology Authors: Franz H. Messerli, Gurusher S. Panjrath Tags: VIEWPOINT AND COMMENTARY Source Type: journals
Hypertension and the “J-Curve”Email this article to a colleague.
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Elevated blood pressure (BP) is one of the most common preventable causes of premature death worldwide. Approximately 8 million deaths/year (i.e., 14% of all deaths worldwide) are directly attributable to an elevated BP, and with the worldwide prevalence of hypertension predicted to increase by more than 50% by 2025, the magnitude of BP-related death is set to increase further (). Abundant data from randomized clinical trials have confirmed that the therapeutic lowering of BP in hypertensive people substantially reduces the risk of cardiovascular morbidity and mortality, and as a consequence, the routine treatment of hyper...
Source: Journal of the American College of Cardiology - November 5, 2009 Category: Cardiology Authors: Bryan Williams Tags: VIEWPOINT AND COMMENTARY Source Type: journals
Predicting Clinically Unrecognized Coronary Artery Disease: Use of Two-Dimensional EchocardiographyEmail this article to a colleague.
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This article provides an answer. Cardiovascular Ultrasound
Source: Medscape Cardiology Headlines - November 5, 2009 Category: Cardiology Tags: Radiology Source Type: info
Cellular Source Of Most Common Type Of Abnormal Heart Beat Study: Findings Could Point To More Precise Treatments For Atrial FibrillationEmail this article to a colleague.
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While studying how the heart is formed, scientists at the University of Pennsylvania School of Medicine serendipitously found a novel cellular source of atrial fibrillation (AF), the most common type of abnormal heart beat.
Source: Cardiovascular / Cardiology News From Medical News Today - November 5, 2009 Category: Cardiology Tags: Cardiovascular / Cardiology Source Type: news
Journal Scan: Sex Differences in Mortality After Acute Myocardial Infarction: Changes From 1994 to 2006 (Arch Intern Med 2009;169:1767-1774. )Email this article to a colleague.
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Data from the National Registry of Myocardial Infarction (NRMI) were used for the present analysis. Temporal trends in MI were examined starting in June 1994 up to December 2006. Hospital case-fatality rates were compared between men and women and between age groups. Patients were excluded if they e. . .
Source: Cardiosource - November 5, 2009 Category: Cardiology Source Type: organizations
New Class Of Molecules May Help Prevent Fatal Complication In Patients With Kidney DiseaseEmail this article to a colleague.
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Researchers at the University of Maryland School of Medicine have made an important discovery about why potassium builds up to dangerous levels in the bloodstream, a relatively common medical problem that affects about eight percent of hospitalized patients. They have identified a new molecular pathway and a new class of molecules responsible for preventing potassium from being excreted normally through the kidney. Their study was just published in the Journal of Clinical Investigation.
Source: Cardiovascular / Cardiology News From Medical News Today - November 5, 2009 Category: Cardiology Tags: Urology / Nephrology Source Type: news
UCLA Researchers Reconstitute Enzyme That Synthesizes Cholesterol Drug LovastatinEmail this article to a colleague.
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Researchers from the UCLA Henry Samueli School of Engineering and Applied Science have for the first time successfully reconstituted in the laboratory the enzyme responsible for producing the blockbuster cholesterol-lowering drug lovastatin. The research, published Oct. 23 in the journal Science, could potentially lead to the development of other compounds with similarly beneficial effects.
Source: Cholesterol News From Medical News Today - November 5, 2009 Category: Cardiology Tags: Statins Source Type: news
Percutaneous pulmonic valve implantationEmail this article to a colleague.
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Opinion statement Surgically placed valve conduits between the right ventricle and pulmonary artery often fail within 10 years. The failure
may be the result of insufficiency, stenosis, or often a combination of the two. Pulmonic valve insufficiency may lead to
right ventricular dilatation, heart failure, arrhythmias, and death. Reoperation requires cardiopulmonary bypass, which may
aggravate an already failing right ventricle, and is associated with a higher risk of death and significant morbidity. Therefore,
percutaneous implantation of a pulmonic valve is an attractive option to improve hemodynamic functi...
Source: Current Treatment Options in Cardiovascular Medicine - November 5, 2009 Category: Cardiology Tags: Current Treatment Options in Cardiovascular Medicine Source Type: journals
Combined PCI and minimally invasive heart valve surgery for high-risk patientsEmail this article to a colleague.
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Opinion statement Combined coronary artery valvular heart disease is a major cause of morbidity and mortality in the adult patient population.
The standard treatment for such disease has been open heart surgery in which coronary artery bypass grafting (CABG) is performed
concurrently with valve surgery using a median sternotomy and cardiopulmonary bypass. With the increasing complexity of patients
referred to surgery, some patients may prove to be poor surgical candidates for combined valve and CABG surgery. In certain
selected patients who fall into this category, valve surgery and percutaneous coronary int...
Source: Current Treatment Options in Cardiovascular Medicine - November 5, 2009 Category: Cardiology Tags: Current Treatment Options in Cardiovascular Medicine Source Type: journals
Update on renin-angiotensin-aldosterone blockade in heart failureEmail this article to a colleague.
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Opinion statement There is convincing evidence that the renin-angiotensin-aldosterone system (RAAS) plays an important role in heart failure
(HF), from the events that result in its inception through advanced disease. In particular, RAAS activation is one of the
major pathways involved in maladaptive cardiac remodeling, a process that results in progressive cardiac dysfunction. Not
surprisingly, strategies targeting the RAAS have substantial benefits in HF. These therapies, which include angiotensin-converting
enzyme inhibitors, angiotensin receptor blockers, and aldosterone receptor antagonists, have emerge...
Source: Current Treatment Options in Cardiovascular Medicine - November 5, 2009 Category: Cardiology Tags: Current Treatment Options in Cardiovascular Medicine Source Type: journals
The genetics of cardiomyopathy: Genotyping and genetic counselingEmail this article to a colleague.
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Opinion statement Three decades of ongoing research into the identification of genes responsible for both cardiomyopathies and ion channel diseases
has facilitated a progressive understanding of the pathophysiology of inherited arrhythmogenic diseases. Recent discoveries
in the area of genetics promise to significantly change the current clinical practice of cardiology, as rapid advances in
technology and a coincident reduction of costs associated with sequencing have pushed the “translation“ of genomic information
from bench to bedside. In turn, clinicians have at their disposal new tools for more accur...
Source: Current Treatment Options in Cardiovascular Medicine - November 5, 2009 Category: Cardiology Tags: Current Treatment Options in Cardiovascular Medicine Source Type: journals
Obstructive sleep apnea and heart failureEmail this article to a colleague.
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Opinion statement Obstructive sleep apnea (OSA) exerts several effects that may be particularly deleterious in patients with heart failure (HF).
OSA should be considered especially in HF patients who are obese or have the metabolic syndrome, systemic hypertension, or
pulmonary hypertension. HF patients in whom OSA is suspected should undergo a full evaluation by a sleep specialist, including
a polysomnogram, to diagnose OSA and differentiate this disease from central sleep apnea. Those found to have OSA should then
receive continuous positive airway pressure and/or other interventions, and standard disease m...
Source: Current Treatment Options in Cardiovascular Medicine - November 5, 2009 Category: Cardiology Tags: Current Treatment Options in Cardiovascular Medicine Source Type: journals
Mitral valve repair in the treatment of mitral regurgitationEmail this article to a colleague.
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Opinion statement Because there is no proven effective medical therapy for mitral regurgitation (MR), mitral valve repair (MVRpr) is the treatment
of choice for patients with severe primary nonrheumatic MR. A successfully performed and properly timed MVRpr may lead to
a normal lifestyle and life span. The alternative to repair is mitral valve replacement. Although there have been no randomized
trials of repair versus replacement, almost all reported series demonstrate superior outcomes with repair, and current guidelines
clearly prefer MVRpr over mitral valve replacement for patients with nonrheumatic MR.
...
Source: Current Treatment Options in Cardiovascular Medicine - November 5, 2009 Category: Cardiology Tags: Current Treatment Options in Cardiovascular Medicine Source Type: journals
Transcatheter aortic valve implantationEmail this article to a colleague.
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Opinion statement Aortic stenosis is the most important valvular heart disease affecting the elderly population. Surgical aortic valve replacement
is the mainstay of treatment, although a substantial number of patients are considered high risk for surgery. Many of these
patients do not undergo surgery and have poor outcomes from medically treated symptomatic, severe aortic stenosis. Transcatheter
aortic valve implantation (TAVI) provides a promising treatment option for some of these patients. Several devices are under
investigation. The Edwards Sapien valve (Edwards Lifesciences, Irvine, CA) and the CoreVal...
Source: Current Treatment Options in Cardiovascular Medicine - November 5, 2009 Category: Cardiology Tags: Current Treatment Options in Cardiovascular Medicine Source Type: journals
Percutaneous approaches to mitral regurgitationEmail this article to a colleague.
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Opinion statement Percutaneous therapy for mitral repair has emerged over the past several years as an investigational option for treating mitral
regurgitation (MR). A variety of novel methods to treat MR using a percutaneous route have been developed. Most of these approaches
are modifications of surgical techniques, some established and some obscure. The basic surgical approaches to mitral repair
are annuloplasty and leaflet repair. Catheter-based devices mimic or approximate these surgical approaches. MR as a disease
process is heterogeneous, and different therapeutic approaches are needed for different e...
Source: Current Treatment Options in Cardiovascular Medicine - November 5, 2009 Category: Cardiology Tags: Current Treatment Options in Cardiovascular Medicine Source Type: journals
How to use diuretics in heart failureEmail this article to a colleague.
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Opinion statement Systemic and pulmonary congestion is a central aspect of both acute and chronic heart failure and directly leads to many of
the clinical manifestations of these syndromes. Therefore, diuretic therapy to treat congestion plays a fundamental role in
heart failure management. However, although diuretics are the most common drugs prescribed for heart failure, there is limited
quality evidence to guide their use. Unlike other components of the heart failure armamentarium, such as β-blockers and angiotensin-converting
enzyme inhibitors, diuretics (with the exception of aldosterone antagonists) h...
Source: Current Treatment Options in Cardiovascular Medicine - November 5, 2009 Category: Cardiology Tags: Current Treatment Options in Cardiovascular Medicine Source Type: journals
