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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 2.

AHA: Air Pollution Link to Thrombosis Fades Away (CME/CE)email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
ORLANDO (MedPage Today) -- Researchers said they were unable to replicate a link between ambient particulate matter air pollution and venous thromboembolism in women using estrogens.
Source: MedPage Today Cardiovascular - November 19, 2009 Category: Cardiology Source Type: news

ALLHAT investigators report 10-year follow-up and stand by diuretics as first step antihypertensive treatmentemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
New 10-year mortality and morbidity data confirm the original trial conclusions, they say, that while amlodipine and lisinopril are not superior to chlorthalidone on any outcome, chlorthalidone is superior to these agents on one or more secondary end points. Full agreement with this conclusion in the community, though, is still hard to come by.
Source: theHeart.org - November 19, 2009 Category: Cardiology Source Type: info

AHA: Drilling Down in JUPITER Confirms Benefit for Women (CME/CE)email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
ORLANDO (MedPage Today) -- A subset analysis of data from the JUPITER trial indicates that apparently healthy women treated with rosuvastatin (Crestor) reduced their relative risk of major cardiovascular events by 46%, slightly higher than the 42% reduction seen in men.
Source: MedPage Today Cardiovascular - November 19, 2009 Category: Cardiology Source Type: news

AHA: Diuretics Measure Up to Newer BP Drugs (CME/CE)email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
ORLANDO (MedPage Today) -- Over the long term, diuretics fight hypertension as well as newer, more expensive blood pressure medications, researchers said here.
Source: MedPage Today Cardiovascular - November 19, 2009 Category: Cardiology Source Type: news

Goal-directed Haemodynamic Therapy and Gastrointestinal Complications in Major Surgery: A Meta-Analysis of Randomized Controlled Trialsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Investigators performed a meta-analysis to examine the effects of goal-directed hemodynamic therapy on postoperative gastrointestinal and hepatic complications. British Journal of Anaesthesia
Source: Medscape Cardiology Headlines - November 19, 2009 Category: Cardiology Tags: Anesthesiology Source Type: info

AHA: Obesity Okay with Some People (CME/CE)email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
ORLANDO (MedPage Today) -- Nearly one obese person in 10 feels no need to lose weight or prevent further weight gain, researchers found.
Source: MedPage Today Cardiovascular - November 19, 2009 Category: Cardiology Source Type: news

AHA: Cardiac Care No Better with Report Cards (CME/CE)email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
ORLANDO (MedPage Today) -- Issuing public report cards on various aspects of hospitals' delivery of cardiovascular care did not improve overall care, a Canadian study showed.
Source: MedPage Today Cardiovascular - November 19, 2009 Category: Cardiology Source Type: news

Implementation of device therapy (cardiac resynchronization therapy and implantable cardioverter defibrillator) for patients with heart failure in Europe: changes from 2004 to 2008email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion Implantation rates of devices for HF, in particular ICD and CRT-D, have increased significantly between 2004 and 2008 in Europe, but there remain major differences between countries.
Source: European Journal of Heart Failure - November 19, 2009 Category: Cardiology Authors: van Veldhuisen, D. J., Maass, A. H., Priori, S. G., Stolt, P., van Gelder, I. C., Dickstein, K., Swedberg, K. Tags: EPIDEMIOLOGY Source Type: journals

Red cell distribution width has incremental prognostic value to B-type natriuretic peptide in acute heart failureemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: European Journal of Heart Failure - November 19, 2009 Category: Cardiology Authors: Jackson, C. E., Dalzell, J. R., Bezlyak, V., Tsorlalis, I. K., Myles, R. C., Spooner, R., Ford, I., Petrie, M. C., Cobbe, S. M., McMurray, J. J.V. Tags: BIOMARKERS Source Type: journals

Red cell distribution width: an inexpensive and powerful prognostic marker in heart failureemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion Red cell distribution width is a readily available test in the HF-population with similar independent prognostic power to NT-proBNP across the first to third quartiles. Prognostic models in HF should include RDW and further investigation is necessary to determine the pathological mechanism of the relationship.
Source: European Journal of Heart Failure - November 19, 2009 Category: Cardiology Authors: Al-Najjar, Y., Goode, K. M., Zhang, J., Cleland, J. G.F., Clark, A. L. Tags: BIOMARKERS Source Type: journals

Increased plasma retinol binding protein 4 levels in patients with inflammatory cardiomyopathyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion Elevated RBP 4 plasma concentrations, induced by IL-8, might be one mechanism leading to a higher incidence of diabetes in patients with DCMi.
Source: European Journal of Heart Failure - November 19, 2009 Category: Cardiology Authors: Bobbert, P., Weithauser, A., Andres, J., Bobbert, T., Kuhl, U., Schultheiss, H. P., Rauch, U., Skurk, C. Tags: BIOMARKERS Source Type: journals

Right atrial size and deformation in patients with dilated cardiomyopathy undergoing cardiac resynchronization therapyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion Right atrial area index was increased and RA myocardial deformation was impaired in patients with DCM who were non-responders to CRT.
Source: European Journal of Heart Failure - November 19, 2009 Category: Cardiology Authors: D'Andrea, A., Scarafile, R., Riegler, L., Salerno, G., Gravino, R., Cocchia, R., Castaldo, F., Allocca, F., Limongelli, G., Di Salvo, G., Cuomo, S., Pacileo, G., Caso, P., Russo, M. G., Calabro, R. Tags: ECHOCARDIOGRAPHY Source Type: journals

Cardiac mortality in {beta}-thalassemia major: resting but not dobutamine stress echocardiography predicts mortality among initially cardiac disease-free patients in a prospective 12-year studyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: European Journal of Heart Failure - November 19, 2009 Category: Cardiology Authors: Hahalis, G., Kourakli, A., Gerasimidou, I., Kalogeropoulos, A. P., Sitafidis, G., Papageorgiou, U., Davlouros, P., Grapsas, N., Zoumbos, N. C., Alexopoulos, D. Tags: ECHOCARDIOGRAPHY Source Type: journals

The impact of concurrent heart failure on prognosis in patients with chronic obstructive pulmonary diseaseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion Heart failure is a strong independent predictor of all-cause mortality in patients with a diagnosis of COPD.
Source: European Journal of Heart Failure - November 19, 2009 Category: Cardiology Authors: Boudestein, L. C.M., Rutten, F. H., Cramer, M. J., Lammers, J. W. J., Hoes, A. W. Tags: PROGNOSIS Source Type: journals

The obesity paradox in stable chronic heart failure does not persist after matching for indicators of disease severity and confoundersemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion The obesity paradox does not appear to persist in a matched setting with respect to indicators of disease severity and other confounders. NT-proBNP remains an independent prognostic indicator of adverse outcome irrespective of obesity status.
Source: European Journal of Heart Failure - November 19, 2009 Category: Cardiology Authors: Frankenstein, L., Zugck, C., Nelles, M., Schellberg, D., Katus, H. A., Remppis, B. A. Tags: PROGNOSIS Source Type: journals

Effect of simvastatin vs. rosuvastatin on adiponectin and haemoglobin A1c levels in patients with non-ischaemic chronic heart failureemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion These findings suggest that hydrophilic rosuvastatin but not lipophilic simvastatin increases adiponectin and decreases HbA1c levels in patients with NICHF.
Source: European Journal of Heart Failure - November 19, 2009 Category: Cardiology Authors: Tsutamoto, T., Yamaji, M., Kawahara, C., Nishiyama, K., Fujii, M., Yamamoto, T., Horie, M. Tags: TREATMENT Source Type: journals

Depressive symptoms and outcomes in patients with heart failure: data from the COACH studyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion In patients with HF, depression is independently associated with poor outcomes. These findings highlight the need for continued exploration of whether improvements in depression lead to better cardiovascular outcomes. The study was registered at clinical trial (www.trialregister.nl): NCT 98675639.
Source: European Journal of Heart Failure - November 19, 2009 Category: Cardiology Authors: Lesman-Leegte, I., van Veldhuisen, D. J., Hillege, H. L., Moser, D., Sanderman, R., Jaarsma, T. Tags: DEPRESSION Source Type: journals

'Hospital at home' care model as an effective alternative in the management of decompensated chronic heart failureemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion Hospital at home care allows an important reduction in the costs during the index episode compared with hospital care, whilst maintaining similar outcomes with respect to cardiovascular mortality and morbidity and quality of life at 1 year follow-up.
Source: European Journal of Heart Failure - November 19, 2009 Category: Cardiology Authors: Mendoza, H., Martin, M. J., Garcia, A., Aros, F., Aizpuru, F., Regalado De Los Cobos, J., Bello, M. C., Lopetegui, P., Cia, J. M. Tags: MANAGEMENT Source Type: journals

Clinical trials update from the European Society of Cardiology Meeting 2009: AAA, RELY, PROTECT, ACTIVE-I, European CRT survey, German pre-SCD II registry, and MADIT-CRTemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This article provides information and a commentary on trials relevant to the pathophysiology, prevention, and treatment of heart failure presented at the annual meeting of the European Society of Cardiology held in Barcelona in 2009. The AAA study does not support the routine use of aspirin for the prevention of vascular events in patients with asymptomatic atherosclerosis. RELY suggests that dabigatran may be more effective than warfarin for the prevention of stroke in patients with atrial fibrillation. Rolofylline was not superior to placebo in improving outcomes in patients with acute heart failure enrolled in the PROTE...
Source: European Journal of Heart Failure - November 19, 2009 Category: Cardiology Authors: Cleland, J. G.F., Coletta, A. P., Yassin, A., Buga, L., Torabi, A., Clark, A. L. Tags: MEETING REPORT Source Type: journals

The prognostic role of echocardiographic indices in chronic heart failure: right ventricle revisitedemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: European Journal of Heart Failure - November 19, 2009 Category: Cardiology Authors: Farmakis, D., Parissis, J., Kremastinos, D. T. Tags: LETTER TO THE EDITOR Source Type: journals

The Nobel Prize for medicine for telomere biology and relevance to heart failure researchemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: European Journal of Heart Failure - November 19, 2009 Category: Cardiology Authors: van der Harst, P., de Boer, R. A., van Veldhuisen, D. J. Tags: EDITORIALS Source Type: journals

Acute coronary syndromes, heart failure, and diabetes in the Gulf Registry of Acute Coronary Eventsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: European Journal of Heart Failure - November 19, 2009 Category: Cardiology Authors: Rosengren, A. Tags: EDITORIALS Source Type: journals

Food-restriction in obese dyslipidaemic diabetic mice partially restores basal contractility but not contractile reserveemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion Food-restriction in obese diabetic mice leads to improved cardiac performance by diminishing cardiac load and by ameliorating the intrinsic contractile properties of the cardiac muscle. However, cardiac reserve under dobutamine stimulation did not increase.
Source: European Journal of Heart Failure - November 19, 2009 Category: Cardiology Authors: Van den Bergh, A., Vangheluwe, P., Vanderper, A., Carmeliet, P., Wuytack, F., Janssens, S., Flameng, W., Holvoet, P., Herijgers, P. Tags: EXPERIMENTAL Source Type: journals

Impaired cellular contractile function in thiamine-deficient rat cardiomyocytesemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: European Journal of Heart Failure - November 19, 2009 Category: Cardiology Authors: Gioda, C. R., Roman-Campos, D., Carneiro-Junior, M. A., da Silva, K. A., de Souza, M. O., Mendes, L. J., Natali, A. J., Cruz, J. S. Tags: EXPERIMENTAL Source Type: journals

Normal systolic blood pressure and risk of heart failure in US male physiciansemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion Our findings suggest a linear relationship between normotensive SBP and HF risk. Strategies to prevent HF, such as lifestyle modification, should be emphasized across all blood pressure ranges.
Source: European Journal of Heart Failure - November 19, 2009 Category: Cardiology Authors: Britton, K. A., Gaziano, J. M., Djousse, L. Tags: EPIDEMIOLOGY Source Type: journals

Heart failure in patients hospitalized with acute coronary syndromes: observations from the Gulf Registry of Acute Coronary Events (Gulf RACE)email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion Heart failure complicates a substantial proportion of ACS admissions in the Arab Middle East and is associated with higher in-hospital death. Younger patients with ACS have a higher relative increase in mortality related to HF.
Source: European Journal of Heart Failure - November 19, 2009 Category: Cardiology Authors: Alsheikh-Ali, A. A., Al-Mallah, M. H., Al-Mahmeed, W., Albustani, N., Al Suwaidi, J., Sulaiman, K., Zubaid, M., for the Gulf RACE Investigators Tags: EPIDEMIOLOGY Source Type: journals

Oral anticoagulants REDEEMed? Daily dabigatran "safe" with dual antiplatelets after MIemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
A dose-finding study saw what were characterized as low bleeding rates associated with triple-drug antithrombotic therapy that included the oral anticoagulant dabigatran in patients with a recent ACS event and other cardiovascular risk factors.
Source: theHeart.org - November 19, 2009 Category: Cardiology Source Type: info

CMS' reimbursements for PET MPI to increaseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The Centers for Medicaid & Medicare Services (CMS) will increase the reimbursement for PET myocardial perfusion imaging (MPI) by 24 percent in 2010.
Source: Cardiovascular Business News - November 19, 2009 Category: Cardiology Tags: Latest News Source Type: news

AHA: Newer Anticoagulants Beat Heparin for PCI (CME/CE)email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
ORLANDO (MedPage Today) -- Acute myocardial infarction patients pretreated with anticoagulants before percutaneous coronary interventions appear to fare better with fondaparinux or enoxaparin than unfractionated heparin, researchers reported.
Source: MedPage Today Cardiovascular - November 19, 2009 Category: Cardiology Source Type: news

EFFECT: Public reporting of hospital performance improves quality of care?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Publicly released report cards based on hospital performance did not result in a measurably greater systemwide improvement in two composite AMI or CHF process-of-care indicators in a Canadian study. But they did appear to stimulate some important changes in delivery of care that could have led to some better outcomes.
Source: theHeart.org - November 19, 2009 Category: Cardiology Source Type: info

AHA: While on statins, better to also raise HDL and not just lower LDL levelsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Orlando, Fla.—The use of statins to reduce LDL-C is more effective with the subsequent addition of extended-release niacin (Niaspan; Abbott), which lowers LDL plus increases HDL, compared with the subsequent administration of ezetimibe (Zetia; Merck) in reducing the progression of atherosclerosis, according to the ARBITER 6-HALTS trial presented Monday at the American Heart Association (AHA) conference.
Source: Cardiovascular Business News - November 19, 2009 Category: Cardiology Tags: Latest News Source Type: news

Study Supports Use Of MTWA Test As Predictor Of Sudden Cardiac Deathemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Cambridge Heart, Inc. (OTCBB-CAMH), announced that results of the PREVENT-SCD trial, presented at the American Heart Association Scientific Sessions in Orlando, Florida, reinforce the value of the Microvolt T-wave Alternans (MTWA) test in identifying patients at risk of sudden cardiac death (SCD).
Source: Cardiovascular / Cardiology News From Medical News Today - November 19, 2009 Category: Cardiology Tags: Cardiovascular / Cardiology Source Type: news

HEAAL: High-dose beats low-dose losartan in HFemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Patients treated with a high, 150-mg daily dose of the angiotensin-receptor blocker losartan had a significantly reduced risk for death or hospitalization for heart failure compared with patients taking a 50-mg daily dose of the drug, the HEAAL investigators report.
Source: MedWire News - Cardiology - November 19, 2009 Category: Cardiology Source Type: news

Inside This Issueemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
1993 Joseph D. Mishkin, Sherry J. Saxonhouse, Gregory W. Woo, Thomas A. Burkart, William M. Miles, Jamie B. Conti, Richard S. Schofield, Samuel F. Sears, Juan M. Aranda, Jr
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals

2009 ACCF/AHA Focused Update on Perioperative Beta Blockade Incorporated Into the ACC/AHA 2007 Guidelines on Perioperative Cardiovascular Evaluation and Care for Noncardiac Surgeryemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Kirsten E. Fleischmann, MD, MPH, FACC, Chair Joshua A. Beckman, MD, FACC
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Lee A. Fleisher, Joshua A. Beckman, Kenneth A. Brown, Hugh Calkins, Elliot L. Chaikof, Kirsten E. Fleischmann, William K. Freeman, James B. Froehlich, Edward K. Kasper, Judy R. Kersten, Barbara Riegel, John F. Robb, American College of Cardiology Foundati Tags: ACCF/AHA PRACTICE GUIDELINES: FULL TEXT Source Type: journals

Anemia in Adults With Congenital Heart Disease Relates to Adverse Outcomeemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Objectives: To assess the relation of anemia in noncyanotic adults with congenital heart disease (ACHD) to functional capacity and mortality.Background: Anemia is common in acquired heart failure and affects prognosis. The presence of anemia and its relation to outcome in ACHD remain unknown.Methods: Data were collected on consecutive noncyanotic ACHD patients attending our tertiary center between 2001 and 2006 in whom hemoglobin concentration was measured. Anemia was defined as hemoglobin concentration
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Konstantinos Dimopoulos, Gerhard-Paul Diller, Georgios Giannakoulas, Ricardo Petraco, Aikaterini Chamaidi, Evaggelia Karaoli, Michael Mullen, Lorna Swan, Massimo F. Piepoli, Philip A. Poole-Wilson, Darrel P. Francis, Michael A. Gatzoulis Tags: CONGENITAL HEART DISEASE Source Type: journals

Coronary Artery Aneurysm Formation Within New-Generation Bare-Metal Stents: Not Just Due to Drug Elution!email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
A 57-year-old woman with chronic stable angina underwent uncomplicated stenting in the left anterior descending artery (LAD) and right coronary artery (RCA) (A) with excellent results in the target vessel. Coronary angiogram repeated for atypical chest pain 6 months later demonstrated coronary artery aneurysm (CAA) (arrowheads) within the segments stented with a bare-metal stent (BMS) in both arteries (B), confirmed on intravascular ultrasound examination (C). Arrows show the extent of the aneurysm as seen on the intravascular ultrasound images. The RCA segment stented with the everolimus-eluting stent Xience (Abbott Labor...
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Sudipta Chattopadhyay, Timothy Kinnaird, Richard A. Anderson Tags: IMAGES IN CARDIOLOGY Source Type: journals

2009 ACCF/AHA Focused Update on Perioperative Beta Blockadeemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Lee A. Fleisher, MD, FACC, FAHA, Chair Joshua A. Beckman, MD, FACC
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Kirsten E. Fleischmann, Joshua A. Beckman, Christopher E. Buller, Hugh Calkins, Lee A. Fleisher, William K. Freeman, James B. Froehlich, Edward K. Kasper, Judy R. Kersten, John F. Robb, R. James Valentine, American College of Cardiology Foundation, Americ Tags: ACCF/AHA PRACTICE GUIDELINES: FOCUSED UPDATE Source Type: journals

The Role of Ganglionated Plexi in Apnea-Related Atrial Fibrillationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: This experimental model of apnea shows a reproducible incidence of AF. After neural ablation of the RPA GP or autonomic blockade, AF inducibility was significantly inhibited.
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Muhammad Ghias, Benjamin J. Scherlag, Zhibing Lu, Guodong Niu, Annerie Moers, Warren M. Jackman, Ralph Lazzara, Sunny S. Po Tags: QUARTERLY FOCUS ISSUE: HEART RHYTHM DISORDERS Source Type: journals

Sleep Apnea and Atrial Fibrillation: The Autonomic Link⁎email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The intuitive and postulated links () between the established association of obstructive sleep apnea with atrial fibrillation (AF) are hypertension, diastolic dysfunction, and the resultant long-term atrial remodeling (). However, studies suggest that the relationship between sleep apnea and AF is independent of hypertension, cardiac function, or body mass index. Further, untreated sleep apnea doubles the risk of AF recurrence within 12 months of cardioversion independent of other risk factors (). Thus, is the relationship between sleep apnea and AF an epiphenomenon, or is it truly causative and the linking mechanism is si...
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Samuel J. Asirvatham, Suraj Kapa Tags: Editorial Comment Source Type: journals

A Meta-Analysis of the Mechanism of Blood Pressure Change With Agingemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: These findings challenge the current consensus view that a shift in timing of wave reflection significantly contributes to the changes in the BP waveform with aging. We should re-evaluate the mechanisms of BP elevation in aging.
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Arun J. Baksi, Thomas A. Treibel, Justin E. Davies, Nearchos Hadjiloizou, Rodney A. Foale, Kim H. Parker, Darrel P. Francis, Jamil Mayet, Alun D. Hughes Tags: HYPERTENSION Source Type: journals

Genotype–Phenotype Relationship in the Long QT Syndrome: Brimming With Knowledge but Thirsting for a Therapeutic Solution⁎email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Since it was first reported 50 years ago, the long QT syndrome (LQTS) is now recognized as a genetic disease caused by mutations of ion channel genes encoding a cardiac channel essential for the control of ventricular repolarization (). The LQTS is not only the most common and extensively researched genetic cardiac arrhythmia (), it has also attracted premier scientists and scholars in single-cell electrophysiology and molecular genetics. In turn, they have produced seminal discoveries that shaped our understanding of the syndrome. The mutated genes in LQTS patients cause delayed repolarization and, in turn, prolong the QT...
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Koonlawee Nademanee Tags: Editorial Comment Source Type: journals

The RYR2-Encoded Ryanodine Receptor/Calcium Release Channel in Patients Diagnosed Previously With Either Catecholaminergic Polymorphic Ventricular Tachycardia or Genotype Negative, Exercise-Induced Long QT Syndrome: A Comprehensive Open Reading Frame Mutational Analysisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This study was undertaken to determine the spectrum and prevalence of mutations in the RYR2-encoded cardiac ryanodine receptor in cases with exertional syncope and normal corrected QT interval (QTc).Background: Mutations in RYR2 cause type 1 catecholaminergic polymorphic ventricular tachycardia (CPVT1), a cardiac channelopathy with increased propensity for lethal ventricular dysrhythmias. Most RYR2 mutational analyses target 3 canonical domains encoded by
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Argelia Medeiros-Domingo, Zahurul A. Bhuiyan, David J. Tester, Nynke Hofman, Hennie Bikker, J. Peter van Tintelen, Marcel M.A.M. Mannens, Arthur A.M. Wilde, Michael J. Ackerman Tags: QUARTERLY FOCUS ISSUE: HEART RHYTHM DISORDERS Source Type: journals

Transesophageal Echocardiography Before Atrial Fibrillation Ablation: Looking Before Cooking⁎email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
In many electrophysiology laboratories, atrial fibrillation (AF) is becoming the most common heart rhythm disorder being treated with catheter ablation. Reasons for this include the large numbers of patients with AF, the poor quality of life commonly associated with AF, the limitations of drug therapy, advances in ablation tools and methods, and the increasing number of electrophysiologists trained in the technique. Catheter ablation is now recognized as a legitimate option for patients with symptomatic AF who have failed antiarrhythmic drug therapy ().
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Bradley P. Knight Tags: Editorial Comment Source Type: journals

A Comparison of Atrial Arrhythmias After Heart or Double-Lung Transplantation at a Single Center: Insights Into the Mechanism of Post-Operative Atrial Fibrillationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: In heart transplant recipients, AF is uncommon and occurs in the setting of myocardial dysfunction and graft rejection. In contrast, AF is more common after lung transplantation despite the absence of graft rejection and cardiac dysfunction. Pulmonary vein isolation alone cannot explain the discrepancy in AF incidence between heart transplant recipients and double-lung transplant recipients. Cardiac autonomic denervation may have a protective effect for heart transplant patients in the post-operative setting.
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: José Dizon, Kimberly Chen, Matthew Bacchetta, Michael Argenziano, Donna Mancini, Angelo Biviano, Joshua Sonett, Hasan Garan Tags: QUARTERLY FOCUS ISSUE: HEART RHYTHM DISORDERS Source Type: journals

Atrial Fibrillation After Major Thoracic Surgery: New Insights Into Underlying Mechanisms⁎email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Atrial fibrillation (AF) is a common complication in patients undergoing major thoracic surgery (). It is most frequently observed acutely after valve surgery and/or coronary artery bypass graft surgery (CABG), but it can also manifest after lung and heart transplantation procedures (). Although mechanisms underlying this unique form of AF have not been adequately elucidated, it is likely that these involve a combination of pericardial inflammation, myocardial ischemia, catecholamine surge, autonomic imbalance, interstitial fluid mobilization, tissue rejection, and so forth (). It is interesting to note that AF is observed...
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Sanjay Dixit Tags: Editorial Comment Source Type: journals

Genotype-Phenotype Aspects of Type 2 Long QT Syndromeemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: The KCNH2 missense mutations located in the transmembrane S5-loop-S6 region are associated with the greatest risk.
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Wataru Shimizu, Arthur J. Moss, Arthur A.M. Wilde, Jeffrey A. Towbin, Michael J. Ackerman, Craig T. January, David J. Tester, Wojciech Zareba, Jennifer L. Robinson, Ming Qi, G. Michael Vincent, Elizabeth S. Kaufman, Nynke Hofman, Takashi Noda, Shiro Kamak Tags: QUARTERLY FOCUS ISSUE: HEART RHYTHM DISORDERS Source Type: journals

Clinical Benefits of Remote Versus Transtelephonic Monitoring of Implanted Pacemakersemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: The strategic use of remote pacemaker interrogation follow-up detects actionable events that are potentially important more quickly and more frequently than transtelephonic rhythm strip recordings. The use of transtelephonic rhythm strips for pacemaker follow-up is of little value except for battery status determinations. (PREFER [Pacemaker Remote Follow-up Evaluation and Review]; NCT00294645)
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: George H. Crossley, Jane Chen, Wassim Choucair, Todd J. Cohen, Douglas C. Gohn, W. Ben Johnson, Eleanor E. Kennedy, Luc R. Mongeon, Gerald A. Serwer, Hongyan Qiao, Bruce L. Wilkoff, PREFER Study Investigators Tags: QUARTERLY FOCUS ISSUE: HEART RHYTHM DISORDERS Source Type: journals

Transtelephonic Versus Remote Monitoring of Cardiovascular Implantable Electronic Devices: Is One Approach to Be Preferred?⁎email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Intracardiac pacemaker implantation was first described a half century ago; the same authors first reported on transtelephonic monitoring (TTM) of such devices a dozen years later (). Follow-up of the pacemaker patient was recognized as critical, particularly in view of the uncertain reliability associated with leads and generators. Tracking device longevity and function have remained an important problem (), compounded by the development of more widespread indications for pacemakers (), increasingly complex devices, and mounting advisories that attest to an ever-present threat of premature device failure (). Ironically, t...
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Mark H. Schoenfeld Tags: Editorial Comment Source Type: journals

Atrial Fibrillation at Baseline and During Follow-Up in ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial)email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Objectives: The ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial) determined that treatment with amlodipine, lisinopril, or doxazosin was not superior to thiazide-like diuretic (chlorthalidone) in preventing coronary heart disease (CHD) or other cardiovascular events. This subanalysis examines baseline prevalence and in-trial incidence of new-onset atrial fibrillation (AF) or atrial flutter (AFL) and their influence on clinical outcomes.Background: Limited information is available on whether atrial fibrillation incidence is affected differentially by different classes of antihypertensive ...
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: L. Julian Haywood, Charles E. Ford, Richard S. Crow, Barry R. Davis, Barry M. Massie, Paula T. Einhorn, Angela Williard, ALLHAT Collaborative Research Group Tags: QUARTERLY FOCUS ISSUE: HEART RHYTHM DISORDERS Source Type: journals