Cardiology
This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. 
Subscribe to this data using MyMedWorm.
Subscribe to this data using GoogleReader.
Subscribe to this data using Bloglines.
Subscribe to this data using MyYahoo.
Looking for a medical communications company? MedWrite International specializes in delivering global strategic medical marketing communications. Visit MedWrite's site to learn more.
This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 25.
Epicardium-Derived Cells as Progenitors of Cardiac Fibroblasts: A Possible Role in Arrhythmogenic Right Ventricular Cardiomyopathy?
Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC) is an inherited disease characterized by replacement of healthy myocardium with fibrous and fatty tissue, cardiac arrhythmias, and sudden death. ARVC has been associated with mutations in desmosomal proteins, most prominently in the gene coding for plakophilin-2 (PKP2). How disruption of desmosomal proteins in cardiac myocytes leads to the disproportionate extent of fibrosis, and fat accumulation, observed in ARVC-afflicted hearts is unclear. Here, we propose that fibrofatty infiltration has its origins (at least in part) in nonmyocyte cardiac cells. Our atte...
Source: Heart Rhythm - November 1, 2009 Category: Cardiology Authors: Stephanie Matthes, Steven Taffet, Mario Delmar Tags: Cardiac Electrophysiology Society Abstracts Source Type: journals
Overexpression of Dipeptidyl-Aminopeptidase-Like Protein 6 (DPP6) Alters Action Potential Characteristics through Effects on Ito1Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Through genetic studies in multiple linked families, we previously identified dipeptidyl-aminopeptidase-like protein 6 (DPP6) as a gene for idiopathic ventricular fibrillation and proposed increased expression of this gene as a likely pathogenic mechanism in this disorder. Co-expression studies in heterologous expression systems point to DPP6 as a putative β-subunit of human cardiac Kv4.3 transient outward current, but the function of DPP6 in native cardiac myocytes is unknown. Here we studied the effects of DPP6 overexpression on action potential and transient outward current characteristics in adult ventricular myocytes.
Source: Heart Rhythm - November 1, 2009 Category: Cardiology Authors: Tamara T. Koopmann, Arie O. Verkerk, Geert J. Boink, Carol A. Remme, Maaike Buskermolen, Hanno L. Tan, Arthur A. Wilde, Connie R. Bezzina Tags: Cardiac Electrophysiology Society Abstracts Source Type: journals
Coupling of Isolated Adult Rabbit Ventricular Myocytes to Fibroblasts Under Stress Induces AfterdepolarizationsEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Ventricular fibrillation (VF) is the most lethal cardiac arrhythmia, yet the underlying mechanisms are poorly understood. VF occurs most commonly in the presence of markedly increased tissue fibrosis, as seen in aging or heart disease. We hypothesize that electrotonic coupling of ventricular myocytes to fibroblasts under stress can augment stress effects to impair myocyte repolarization reserve and promote the emergence of known VF triggers such as early afterdepolarizations (EADs) and triggered activity.
Source: Heart Rhythm - November 1, 2009 Category: Cardiology Authors: Thao P. Nguyen, James N. Weiss Tags: Cardiac Electrophysiology Society Abstracts Source Type: journals
Discrepancy Between Acute and Long-Term Effects of the Calmodulin-Camkii-Calcineurin Pathway on Arrhythmogenesis in the CAVB DogEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Activation of calcium/calmodulin-dependent protein kinase II (CaMKII) has been linked to arrhythmias and heart failure. Through calcineurin, CaMKII has also been implicated in inducing electrical remodeling. Enhanced susceptibility to arrhythmias based on electrical remodeling is also present in the chronic AV block (CAVB) dog, although in the setting of physiologic hypertrophy. Because the stimuli involved (increased angiotensin II, norepinephrine, and intracellular calcium) are known CaMKII activators, this study addressed the involvement of the CaMKII-calcineurin pathway at different time points (0, 2, and 9 weeks) in t...
Source: Heart Rhythm - November 1, 2009 Category: Cardiology Authors: Vincent J.A. Bourgonje, Marieke Schoenmakers, Jet D.M. Beekman, Roel van der Nagel, Leon J. de Windt, Toon A.B. van Veen, Marc A. Vos Tags: Cardiac Electrophysiology Society Abstracts Source Type: journals
Efficacy and Safety of Catheter Ablation of Ventricular Tachycardia in Elderly Patients with Coronary Heart DiseaseEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Control of recurrent ventricular tachycardia (VT) is an important determinant of quality of life in patients with implantable defibrillators. The role of invasive catheter ablation for this purpose in elderly patients with ischemic heart disease has not been defined.
Source: Heart Rhythm - November 1, 2009 Category: Cardiology Authors: Keiichi Inada, Kurt C. Roberts-Thomson, Daniel Steven, Jens Seiler, Bruce A. Koplan, Usha B. Tedrow, William G. Stevenson Tags: Cardiac Electrophysiology Society Abstracts Source Type: journals
NOS1AP Is a Genetic Modifier of Congenital Long-QT SyndromeEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
In the long-QT syndrome (LQTS), genetic factors other than the primary mutation may modify the probability of life-threatening events. Genome-wide association studies did show that polymorphisms in NOS1AP, a regulator of neuronal nitric oxide synthase, are associated not only with baseline QT interval but also with the risk of SCD in white adults. We tested the hypothesis that common variants in NOS1AP might modify the risk of clinical manifestations and the degree of QT interval prolongation in a South African LQTS population segregating a founder mutation in KCNQ1 (A341V), and thus having an identical arrhythmogenic substrate.
Source: Heart Rhythm - November 1, 2009 Category: Cardiology Authors: Lia Crotti, Roberto Insolia, Maria Cristina Monti, Matteo Pedrazzini, Erika Taravelli, Anna Peljto, Althea Goosen, Paul A. Brink, David A. Greenberg, Peter J. Schwartz, Alfred L. George Tags: Cardiac Electrophysiology Society Abstracts Source Type: journals
The Effect of Open - Irrigated Radiofrequency Catheter Ablation of Atrial Fibrillation on Left Atrial Pressure and B-Type Natriuretic PeptideEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Open-irrigated radiofrequency catheter ablation (oiRFA) of atrial fibrillation (AF) imposes a volume load and risk of cardiac decompensation. We sought to assess the effect of volume administration during ablation on left atrial (LA) pressure and B-type natriuretic peptide (BNP).
Source: Heart Rhythm - November 1, 2009 Category: Cardiology Authors: Jens Seiler, Daniel Steven, Kurt C. Roberts-Thomson, Keiichi Inada, Usha B. Tedrow, Gregory F. Michaud, William G. Stevenson Tags: Cardiac Electrophysiology Society Abstracts Source Type: journals
ANP and PAI-1 Levels Predict Successful DC-Cardioversion for Persistent Atrial FibrillationEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Atrial Fibrillation (AF), the most common sustained arrhythmia in clinical practice. Despite improvement in treatment, most patients suffer from symptoms and recurrences of arrhythmia. Studies on the neurohormonal remodeling in AF have become increasingly important in AF. The aim of this study was to measure plasma biomarkers in patients with AF, before and after electrical cardioversion.
Source: Heart Rhythm - November 1, 2009 Category: Cardiology Authors: Juan-Carlos Estrada, Rachel Richardson, Cindy Chen, Dawood Darbar Tags: Cardiac Electrophysiology Society Abstracts Source Type: journals
Patients with Increasing Over Time Intracardiac Repolarization Lability Experience a Greater Increase in Their Probability of Having Ventricular TachyarrhythmiaEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
It is known that elevated at baseline intracardiac repolarization lability increases the risk of life-threatening ventricular tachyarrhythmias (VT/VF) in patients with structural heart disease. We hypothesize that patients with increasing over 6 months period beat-to-beat QT variability experience a greater increase in their probability of having VT/VF than those with decreasing or stable low intracardiac repolarization lability.
Source: Heart Rhythm - November 1, 2009 Category: Cardiology Authors: Larisa Tereshchenko, Barry Fetics, Ronald Berger Tags: Cardiac Electrophysiology Society Abstracts Source Type: journals
Cardiac Resynchronization Therapy in Patients with Recurrent Heart Failure and Intermittent LBBBEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Indications for cardiac resynchronization therapy (CRT) include prolonged QRS duration (typically LBBB), advanced heart failure (HF, NYHA III/IV), and severe left ventricular (LV) dysfunction. The role of CRT in patients with intermittent LBBB associated with acute HF is unknown.
Source: Heart Rhythm - November 1, 2009 Category: Cardiology Authors: Rehan Mahmud, Alawi A. Alsheikh-Ali, Salem Alkaabi, Arshad Rasheed Tags: Cardiac Electrophysiology Society Abstracts Source Type: journals
NPPA Gain-of-Function Mutation Associated with Familial Atrial FibrillationEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Studies have increasingly identified genetics as an important predisposing factor for developing atrial fibrillation (AF). Mutations in NPPA, encoding the circulating hormone atrial natriuretic peptide (ANP) as well as other functional proteins, have recently been implicated in familial AF. The mechanisms underlying AF susceptibility with mutant NPPA however remain uncertain.
Source: Heart Rhythm - November 1, 2009 Category: Cardiology Authors: Robert L. Abraham, Tao Yang, Marcia Blair, Dan M. Roden, Dawood Darbar Tags: Cardiac Electrophysiology Society Abstracts Source Type: journals
Implantable Cardiac Devices in the Elderly-How Risky Is It?Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Despite the efficacy of implantable cardiac devices in elderly patients, a bias against their use seems to persist. A major concern about placing these devices in elderly patients is the complication rate. The incidence of complications in the elderly are not well recorded from the general population and most randomized trials excluded elderly patients.
Source: Heart Rhythm - November 1, 2009 Category: Cardiology Authors: Senthil Thambidorai, Manu Kaushik, Aimin Chen, Nazih Kadri Tags: Cardiac Electrophysiology Society Abstracts Source Type: journals
Dobutamine Stress Echocardiography: Single Center Studies vs. Meta-Analysis vs. the Real WorldEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
In this issue of the Journal of American Society of Echocardiography, Geleijnse and colleagues from the Thoraxcenter in Rotterdam present an extensive meta-analysis of studies evaluating the diagnostic accuracy of dobutamine stress echocardiography. The authors analyzed the results of 62 studies published between 1991 and 2006, including 6881 patients with angiographic correlation for coronary anatomy. Approximately two thirds of the study subjects had angiographic coronary disease. This extensive meta-analysis confirms the accuracy reported in several smaller similar analyses. For the total cohort of analyzed patients, se...
Source: Journal of the American Society of Echocardiography - November 1, 2009 Category: Cardiology Authors: William F. Armstrong Tags: Editorial Comment Source Type: journals
Myocardial Contrast Echocardiography Enhances Long-Term Prognostic Value of Supine Bicycle Stress Two-Dimensional EchocardiographyEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Conclusions: MCE enhances the predictive power of supine bicycle stress 2DE and allows the risk stratification of patients with normal results on 2DE.
Source: Journal of the American Society of Echocardiography - November 1, 2009 Category: Cardiology Authors: Tomasz Miszalski-Jamka, Stefanie Kuntz-Hehner, Harald Schmidt, Daniel Peter, Karol Miszalski-Jamka, Christoph Hammerstingl, Klaus Tiemann, Alexander Ghanem, Clemens Troatz, Mieczysław Pasowicz, Berndt Lüderitz, Heyder Omran Tags: Clinical Investigations Source Type: journals
Left Ventricular–Arterial CouplingEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
The performance of the cardiovascular system depends on the interaction of its components. The left ventricle pumps its stroke volume into the arterial system, which then delivers the flow to the tissues. Thus, optimal cardiovascular function requires appropriate coupling of the left ventricle and the arterial system. Functional analysis of this interaction requires that the left ventricle and arterial system be described in similar terms. The left ventricle can be evaluated by plotting left ventricular (LV) pressure versus volume through the cardiac cycle (A). The upper left-hand corner of the LV pressure-volume loop is e...
Source: Journal of the American Society of Echocardiography - November 1, 2009 Category: Cardiology Authors: William C. Little, Min Pu Tags: Editorial Comment Source Type: journals
Why Do Mitral Valve Repairs Fail?Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
In this issue of JASE, Magne et al continue their previous work using echocardiography to analyze outcomes of mitral valve repair for ischemic mitral regurgitation, demonstrating that continued adverse left ventricular (LV) remodeling may not be a prerequisite for recurrent mitral valve regurgitation in patients who had undergone initially successful repairs. They observed a group of 26 patients selected from a larger group who had undergone surgical repair for ischemic mitral regurgitation and noted that 10 patients developed recurrent mitral regurgitation within a mean of 18 months after surgery. In those 10 patients, re...
Source: Journal of the American Society of Echocardiography - November 1, 2009 Category: Cardiology Authors: Anelechi C. Anyanwu, David H. Adams Tags: Editorial Comment Source Type: journals
Echocardiographic Findings and Cardiac Surgical Implications of Aortitis and Valvulitis in Behçet's DiseaseEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Inflammatory, noninfectious aortitis is an unusual cause of aortic regurgitation and ascending aortic aneurysm formation, occurring in
Source: Journal of the American Society of Echocardiography - November 1, 2009 Category: Cardiology Authors: Athena Poppas, Michael Coady Tags: Editorial Comment Source Type: journals
Acute Left Ventricular Remodeling After Myocardial Infarction on Transthoracic Echocardiography: A Case SeriesEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
The authors describe left ventricular myocardial changes on transthoracic echocardiography in patients imaged within 72 hours of acute infarction. Endocardial separation from the mid myocardium, echocardiographic contrast penetration into the myocardium, and regional contrast swirling were observed. This case series also illustrates how contrast imaging may enhance recognition of early postinfarction remodeling.
Source: Journal of the American Society of Echocardiography - November 1, 2009 Category: Cardiology Authors: Deepak Koul, Renee Bess, Arshad Rehan, Gerald Cohen Tags: Case Reports Source Type: journals
Table of ContentsEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Source: Journal of the American Society of Echocardiography - November 1, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals
Editorial BoardEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Source: Journal of the American Society of Echocardiography - November 1, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals
Info for AuthorsEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Source: Journal of the American Society of Echocardiography - November 1, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals
Information for ReadersEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Source: Journal of the American Society of Echocardiography - November 1, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals
President's Message: The Value of Belonging: ASE Delivers a Broad Spectrum of Benefits to a Diverse MembershipEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
When Dr. Harvey Feigenbaum founded the American Society of Echocardiography in April of 1976, one of his main drives was to revert an advocacy situation. According to ASE Past President Arthur Weyman, MD, Medicare provided full reimbursement at the time for tests performed by radiologists and pathologists (as non self-referring physicians) and only 80% for tests performed by cardiologists. Given this structure, Dr. Feigenbaum feared that echocardiographic tests would be removed from cardiology. Although he argued against this in several forums, he found himself being the single voice, and therefore decided to create the AS...
Source: Journal of the American Society of Echocardiography - November 1, 2009 Category: Cardiology Tags: American Society of Echocardiography News Source Type: journals
Continuing Education and Meeting CalendarEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
The American Society of Echocardiography recognizes courses as supplements to formal training in an established echocardiographic laboratory. For more information about a course, please call the number listed. To list a course in the Continuing Education and Meeting Calendar, send the date(s), title, location, sponsor, course director(s), and contact information to ASE, Attn: Cheryl Williams, 2100 Gateway Centre Boulevard, Suite 310, Morrisville , NC 27560; Tel: 919-861-5574 x7160; E-mail: cwilliams@asecho.org.
Source: Journal of the American Society of Echocardiography - November 1, 2009 Category: Cardiology Tags: American Society of Echocardiography News Source Type: journals
Pediatric Echocardiography Offers Myriad Challenges, Extraordinary RewardsEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Melissa Pollicino, RDCS, a pediatric sonographer from Children's Hospital of Philadelphia, attended the ASE scientific sessions in Washington, DC last June. Her exuberance and sheer pleasure in her chosen field was very evident, so I asked her to share her story and thoughts on the role of pediatric sonographers, now and in the future.–Marti L. McCulloch
Source: Journal of the American Society of Echocardiography - November 1, 2009 Category: Cardiology Tags: Sonographers' Communication Source Type: journals
Vascular and cardiac ultrasonographers: is it time to use frequencies from the same band-width?Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
As a cardiac and vascular ultrasonographer, I have always been impressed by the several differences between cardiac and vascular ultrasound imaging. Although the principles are the same, the equipment is typically different. Classic vascular ultrasound equipment is not ECG gated, the angles accepted in vascular imaging are different, and so on and so forth. It is safe to say that if you are an expert in one, you are not necessarily an expert in the other.
Source: Journal of the American Society of Echocardiography - November 1, 2009 Category: Cardiology Tags: Vascular Council Communication Source Type: journals
Editorial BoardEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Source Type: journals
EXPLORING THE GENETIC ARCHITECTURE OF LIPID TRAITS IN WHITEHALL II HEALTHY MEN AND WOMEN USING THE 50K-SNP CARDIO-METABOLIC CHIPEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Objectives: GWASs have revolutionised complex disease genetics, but while broad in genome coverage, they lack depth. We have used a 50K SNP-CHIP covering ∼2100 genes involved in cardio-metabolic processes, providing a complementary in-depth approach.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: S.E. Humphries, P.J. Talmud, F. Drenos, S. Shah, S. Palmen, T. Shah, M. Kumari, M. Kivimaki, J. Pallas, J.P. Casas, J. Whittaker, A. Hingorani Tags: HEART UK Annual Conference 2009 Abstracts Source Type: journals
INSULIN LIKE GROWTH FACTOR BINDING PROTEIN-1 PHOSPHORYLATION STATUS IN SUBJECTS WITH AND WITHOUT ISCHEMIC HEART DISEASEEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Background: Insulin like growth factor binding protein-1 (IGFBP-1) modulates the activity of IGF-1. It exists in plasma as phosphorylated and less phosphorylated forms. We wished to study the serum levels of these forms of IGFBP-1, using a novel assay, in subjects with and without ischemic heart disease (IHD).
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: A. Borai, C. Livingstone, M. Ghayour, A. Abuosa, G. Ferns Tags: HEART UK Annual Conference 2009 Abstracts Source Type: journals
GLYCATION OF LDL IS AN IMPORTANT ATHEROGENIC MODIFICATION AND OPPOSED BY PARAOXONASE-RICH HDLEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Introduction: Foam cells, central to atherogenesis, do not form when monocyte-macrophages are exposed to unmodified LDL. Chemical modification of LDL must first occur. Oxidative modification has attracted most interest, but glycated LDL present in the circulation at much higher concentration than oxidized LDL, even in non-diabetic people, equally stimulates foam cell formation. We have recently reported that in patients with and without type 2 diabetes LDL glycation occurs predominantly in SD-LDL and that presence of SD-LDL is a more important determinant of its plasma concentration than glycaemia.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: N. Younis, H. Soran, R. Sharma, P. Pemberton, V. Charlton-Menys, M. France, M. Elsweidy, P. Durrington Tags: HEART UK Annual Conference 2009 Abstracts Source Type: journals
PLASMA PCSK9 LEVELS ARE LOW IN HEALTHY SUBJECTS CARRYING THE PCSK9 P.R46L VARIANT AND IN P.D374Y FAMILIAL HYPERCHOLESTEROL-EMIA PATIENTSEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Background: Loss of function mutations in PCSK9 (p.R46L) cause low plasma LDL-C levels, while gain of function mutations (p.D374Y) cause familial hypercholesterolemia (FH), but their relationship with plasma levels of PCSK9 is unclear.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: S.E. Humphries, D. Neely, R.A. Whittall, J. Troutt, R.J. Konrad, M. Scartezini, Ka Wah Li, J.A. Cooper, J. Acharya, H.A.W. Neil Tags: HEART UK Annual Conference 2009 Abstracts Source Type: journals
INCREASED DIETARY CHOLESTEROL DOES NOT INCREASE PLASMA LOW DENSITY LIPOPROTEIN WHEN ACCOMPANIED BY WEIGHT LOSSEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Background and aims: The observation that high intakes of dietary cholesterol can increase plasma cholesterol in a number of species has led to the belief that the intake of dietary cholesterol, in humans, should be restricted. However, energy-restricted diets, that may contain a relatively high proportion of fat and cholesterol, have been shown to produce neutral or in some cases favourable effects on plasma cholesterol.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: N.L. Harman, A.R. Leeds, B.A. Griffin Tags: HEART UK Annual Conference 2009 Abstracts Source Type: journals
ACHIEVEMENT OF LDL-C LEVELS WITH THREE DIFFERENT DRUG STRATEGIES AFTER FAILURE OF SIMVASTATIN 40MGEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Background: NICE lipid guidelines recommend simvastatin (S) 40mg as initial therapy, after lifestyle changes, in most patients requiring treatment. When desirable levels have not been met, increasing the dose, switching to a more potent statin or adding ezetimibe (E) can be considered. The addition of E to S was compared with switching to atorvastatin (A) or rosuvastatin (R) in a randomised, double-blind trial.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: T. McCormack, M. Blagden, R. Chipperfield, P. Harvey, R. Gaunt, S. Griffiths, P. Robinson Tags: HEART UK Annual Conference 2009 Abstracts Source Type: journals
APOLIPOPROTEIN B PROVIDES A MORE CONSISTENT GOAL OF STATIN TREATMENT THAN LDL-C AND NON-HDL-CEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Introduction: Controversy surrounds whether apolipoproteins are the best discriminator of CHD risk and for monitoring response to statin treatment. There is one apolipoprotein B (apo B) molecule in each LDL particle while the cholesterol content of the low density lipoprotein (LDL) can vary considerably. This is particularly so in patients with combined dyslipidemia and hypertriglyceridemia.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: H. Soran, V. Charlton-Menys, S. Dissanayake, N. Younis, M. France, P.N. Durrington Tags: HEART UK Annual Conference 2009 Abstracts Source Type: journals
IS SMALL DENSE LDL A MORE IMPORTANT DETERMINANT OF THE PLASMA GLYCATED LDL IN TYPE 2 DIABETES THAN GLYCAEMIC CONTROL?Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
The research to date has focused on oxidation of LDL rather than glycation as the modification leading to atherosclerotic cardiovascular diseases. We have recently reported that, in non-diabetic people, small dense LDL (SD-LDL) is preferentially glycated both in vivo and in vitro. The relative contribution of SD-LDL and glycaemia in determining circulating levels of glycated LDL in diabetes is unknown. We investigated the distribution of apoB and glyc-apoB in apoB-containing lipoproteins isolated from 48 patients with type 2 diabetes and 11 healthy volunteers. LDL, LDL1, LDL2 and LDL3 were isolated from a further 63 patien...
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: N. Younis, R. Sharma, H. Soran, P. Pemberton, V. Charlton-Menys, M. Elsweidy, P. Durrington Tags: HEART UK Annual Conference 2009 Abstracts Source Type: journals
ALL-CAUSE AND CARDIOVASCULAR MORTALITY IN TREATED PATIENTS WITH SEVERE HYPERTRIGLYCERIDAEMIA: A LONG-TERM PROSPECTIVE REGISTRY STUDYEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Objective: To examine all-cause and cardiovascular disease (CVD) mortality in patients with severe hypertriglyceridaemia. Design: Prospective registry study.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: H.A.W. Neil, J. Cooper, D.J. Betteridge, N. Capps, I.F.W. McDowell, P.N. Durrington, M. Seed, S.E. Humphries Tags: HEART UK Annual Conference 2009 Abstracts Source Type: journals
BLOOD PRESSURE AND LIPIDS IMPROVEMENT AFTER VERY LOW ENERGY DIET (VLED) OR LOW ENERGY DIET (LED) IN OBESE PATIENTS WITH KNEE OSTEOARTHRITIS: A RANDOMISED CONTROLLED TRIALEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Background: Weight reduction improves cardiac risk factor profiles but there are few recently published RCTs on the effects of formula diets. Methods: Comparing cardiac risk factors after 8 and 16 weeks following ‘very low energy diet’ (VLED) or ‘low energy diet’ (LED) in obese (BMI>30) patients with knee osteoarthritis. Patients were included in strata of 24, randomised via minimisation with allocation concealment to: either 8 weeks on ‘VLED’ (420–554kcal/d) or 8 weeks on a ‘LED’ (810kcal/d) both formula Cambridge diets. The second phase was 8 weeks fixed-energy diet program with food; 1200kcal includin...
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: P. Christensen, H. Bliddal, B.F. Riecke, A.R. Leeds, A. Astrup, R. Christensen Tags: HEART UK Annual Conference 2009 Abstracts Source Type: journals
BODY FAT DISTRIBUTION IN MEN AND WOMEN OF SOUTH ASIAN ORIGIN: AN OBSERVATIONAL STUDYEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Introduction: Mortality from IHD in South Asian men and women are 1.5 times that of the native population in the UK. Alterations in body fat content and particularly body fat distribution are associated with adverse metabolic effects and increased cardiovascular risk. Increased visceral fat in South Asians may not be apparent from their BMI.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: N. Rao, N. Johri, D. Harvey, L. Robertson, M. Thomas, D.P. Mikhaildis, D. Nair Tags: HEART UK Annual Conference 2009 Abstracts Source Type: journals
COMPARISON OF A POINT OF CARE CHOLESTEROL DEVICE AND LABORATORY ANALYSIS IN THE PREDICTION OF CARDIOVASCULAR DISEASEEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Introduction: Based on the Department of Health Vascular Risk Assessment Programme we undertook a pilot scheme to screen a South Asian population attending the Shri Swami Narayan Temple. This screening included lipid measurements using point of care testing equipment (Cholestech LDX, Hayward, USA) and a routine laboratory method. We compared the risk assigned using the Joint British Societies’ 2 (JBS 2) cardiovascular disease (CVD) chart.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: N. Rao, N. Johri, L. Robertson, D. Harvey, B. Persaud, D.P. Mikhailidis, M. Thomas, D. Nair Tags: HEART UK Annual Conference 2009 Abstracts Source Type: journals
FOLLOW YOUR HEART: POST-MYOCARDIAL INFARCTION CAREEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
The Follow Your Heart group is a three-way partnership between HEART UK, the PCCS and Pfizer, and has been financially supported by Pfizer. Background: Clinical guidelines are vital to clinical practice; minimising variation, raising standards, increasing efficiency and improving health outcomes for patients.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: J. Morrell, on behalf of the Follow Your Heart Steering Committee Tags: HEART UK Annual Conference 2009 Abstracts Source Type: journals
CAD RELATED VARIATION ON CHROMOSOME 10q11 IS ASSOCIATED WITH CIRCULATING SDF-1ALPHA LEVEL AND CAROTID INTIMA-MEDIA THICKNESS AND ATHEROSCLEROSISEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
In this study, we investigated whether this locus has an influence on plasma SDF-1alpha level and also examined whether it has effect on carotid intima-media thickness and development of carotid atherosclerosis.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: S. Kiechl, R.C. Laxton, Q. Xiao, J. Willeit, Q. Xu, S. Ye Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals
GPIHBP1 VARIANTS CONTRIBUTE TO LIPID LEVELS IN FAMILIAL COMBINED HYPERLIPIDEMIAEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Familial combined hyperlipidemia (FCHL) is a complex genetic disorder, which predisposes to premature atherosclerosis. In mice, deficiency of glycosylphosphatidylinositol (GPI)-anchored high-density lipoprotein-binding protein (GPIHBP1) causes severe chylomicronemia. GPIHBP1 binds lipoprotein lipase and triglyceride-rich lipoproteins on the luminal surface of endothelial cells. Data examining the role of GPIHBP1 variation in human dyslipidemia are sparse. We therefore performed re-sequencing and association analyses to determine the contribution of GPIHBP1 variation to the aetiology of FCHL in white-British families. The e...
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: H.E. Ringham, M.M. Town, S.D. Horswell, C.C. Shoulders Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals
ANRIL, THE NON CODING RNA PRESENT IN THE CHROMOSOME 9 CAD ASSOCIATED LOCUS, HAS MULTIPLE SPLICE VARIANTS AND A POTENTIAL REGULATORY ROLE IN CDKN2B EXPRESSIONEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Background: Genome-wide association studies have identified a region on chromosome 9 associated with CAD risk and aneurysms. Discovery of a large antisense noncoding RNA (ANRIL) transcribed from the chromosome 9 locus and with the potential to regulate neighbouring genes CDKN2A/B, raises the possibility that the risk variants have primary effects on ANRIL expression leading to tissue and variant-specific effects on the magnitude and balance of CDKN2A/B transcripts. The aims of this study were to (i) determine the expressed ANRIL transcripts and (ii) investigate a potential regulatory role for ANRIL on CDKN2A/B expression.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: T. Kyriakou, A. Pal, J. Peden, F. Green, A. Gloyn, M. McCarthy, H. Watkins Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals
FUNCTIONAL ANALYSIS OF REGULATORY LPL SNPSEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
The aim of this study was to determine novel functional variation in LPL. Using a prospective cohort of 3012 healthy, Caucasian, middle-aged men (NPHSII), variation in LPL was examined using a tagSNP approach comprising 22 SNPs. Association with triglyceride levels was analysed by a number of statistical tests to identify SNPs with the highest likelihood of association. Candidate SNPs and those in high LD were examined for functionality. Electrophoretic mobility shift assay (EMSA) was initially performed to identify SNPs that had the potential to alter transcription factor binding sites. Those that altered DNA–protein in...
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: A.J.P. Smith, F. Drenos, J. Palmen, W. Putt, P.J. Talmud, S.E. Humphries Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals
ASSOCIATION STUDY OF CORONARY ARTERY DISEASE (CAD) USING HUMANCVD 50K CHIPEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Background: Recent GWAS studies have identified several novel susceptibility loci for CAD , but it seems that only common variants can be detected using this approach . Moreover, novel loci identified using GWAS appear to explain only a small amount of the expected contribution to CAD risk. Use of high-density arrays involving multiple single nucleotide polymorphisms (SNPs) in candidate genes for cardiovascular disease, including both common and low frequency variants, may help to elucidate the genetic contribution to CAD risk.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: A. Goel, R. Clarke, J.C. Hopewell, T. Kyriakou, S.C. Heath, S. Parish, S. Barlera, M.G. Franzosi, S. Rust, D. Bennett, A. Silveira, A. Malarstig, F.R. Green, M. Lathrop, B. Gigante, K. Leander, U. Faire, U. Seedorf, A. Hamsten, R. Collins, H. Watkins, M. Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals
ASSOCIATION BETWEEN FTO POLYMORPHISM, ADIPOSITY PEAK AND ADIPOSITY REBOUND IN THE NORTHERN FINLAND BIRTH COHORT 1966Email this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
This study investigated the association between the FTO SNP rs9939609 and both age and BMI at AP and AR using longitudinal data from the Northern Finland Birth Cohort 1966. AP and AR were derived from random effects models fitted at >0–1.5 years and >1.5–13 years (N=2782 infants and N=3413 children with minimum three measurements per age window). Additionally, correlations between derived parameters and BMI at age 31 were studied. Age at AP correlated weakly with BMI at AR (r=0.18) but not at 31 (r=0.02), whereas age at AR correlated inversely with BMI at AR (r=−0.50) and at 31 (r=−0.44). BMI at AP and BMI at AR pr...
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: U. Sovio, N.J. Timpson, N.M. Warrington, L. Briollais, D. Mook-Kanamori, M. Kaakinen, A.J. Bennett, J. Molitor, M.I. McCarthy, M.-R. Jarvelin Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals
APOLIPOPROTEIN E (APOE) GENOTYPE AND ISCHAEMIC STROKE: INTEGRATION OF EVIDENCE FROM A LITERATURE BASED META-ANALYSIS AND A PHENOME SCAN OF EFFECTS ON BLOOD LIPIDS AND OTHER BIOMARKERS OF CARDIOVASCULAR RISKEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Rationale: APOE genotype exhibits approximately linear relationship with LDL-cholesterol concentration and CHD risk but the relationship of APOE genotype with risk of ischemic stroke is less well defined. We evaluated the association of APOE genotype with stroke risk and to assess if the observed effect is consistent with effects on LDL-cholesterol, other lipid fractions or biomarkers of cardiovascular risk.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: APOE Collaboration Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals
A FIELD SYNOPIS OF PHARMACOGENETIC STUDIESEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Rationale for the study: Differences in drug efficacy and/or adverse effects make an important contribution to ill-health. Studying the genetic basis could reduce this by clarifying mechanisms of drug action/metabolism to inform drug development, and lead to genotype-based predictive tests of efficacy or toxicity (pharmacogenetics). The reliable identification of loci for drug response appears less advanced than for susceptibility loci for common disease. We wished to identify blocks to progress to guide future research.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: M.V. Holmes, T. Shah, C. Vickery, L. Smeeth, A.D. Hingorani, J.P. Casas Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals
ASSOCIATION OF VARIANTS IN CANDIDATE GENES INFLUENCING ELECTROLYTE TRANSPORT AND THE AUTONOMIC NERVOUS SYSTEM WITH BLOOD PRESSURE VARIATIONEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Rationale: While heritability of hypertension is estimated to be as high as 60%, identifying the responsible genes is proving challenging. Our strategy was to perform a candidate gene association study with dense tagging SNP coverage of multiple genes selected based on known involvement in two pathways important to BP regulation; electrolyte transport and the autonomic nervous system.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: N. McCarthy, C. Vangjeli, G. Cavaller, N. Delanty, E. O’Brien, B. Harvey, A. Stanton Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals
ASSOCIATION OF TELOMERE LENGTH WITH TYPE 2 DIABETES, OXIDATIVE STRESS AND UCP2 GENE VARIATIONEmail this article to a colleague.
Save this article to My Clippings.
Discuss or comment on this article.
Introduction: Type 2 diabetes (T2D) is characterised by high oxidative stress, which potentially leads to accelerated telomere shortening and consequent premature cell senescence, implicated in the disease development. Therefore, we studied the association of leukocyte telomere length (LTL) with the presence of T2D, as well as the effect on the patients’ LTL of plasma oxidative stress and of variation in UCP2, a gene involved in the mitochondrial production of reactive oxygen species.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: M.C. Smart, C. Ehnholm, M. Jauhiainen, M. Robciuc, J.A. Cooper, F. Drenos, S.E. Humphries, P.J. Talmud Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals
