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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 26.

ANGPTL4 E40K AND T266M: EFFECTS ON PLASMA TRIGLYCERIDE AND HDL LEVELS, ANGPTL4 LEVELS AND CHD RISKemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
We examined the association of two ANGPTL4 coding SNPs and five tagging SNPs with CHD traits in 2772 individuals from the Northwick Park Heart Study II (NPHSII). We also examined the effect of the seven variants, which are in strong linkage disequilibrium, on plasma Angplt4 levels (n=722). In NPHSII the T266M (rs1044250, MAF=30%) and E40K variants (MAF=2%) were significantly associated with TG-lowering (−10.4%, PC encoding the N terminus of Angptl4 were associated with significantly lower Angptl4 levels (P=0.0008 and 0.0002, respectively). T266M and 12574 C>T encoding the C terminus of Angptl4 were associated with signif...
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: M.C. Smart, C. Ehnholm, M. Jauhiainen, M. Robciuc, J.A. Cooper, F. Drenos, S.E. Humphries, P.J. Talmud Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

GENE EXPRESSION PROFILING IN MONONUCLEAR CELLS DEMONSTRATES UP-REGULATION OF PRO-INFLAMMATORY AND ADHESION RELATED GENES CORONARY ARTERY DISEASEemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
We examined expression of genes in circulating mononuclear cells to discover disease specific pathways. Mononuclear cells were extracted from whole blood of patients with coronary artery disease (CAD; n=44) and healthy control subjects (n=44) by Ficoll gradient and superoxide production was measured using EPR spectroscopy. Total RNA was isolated for gene expression profiling (Illumina, Human WG-6 v3.0 chip). Ingenuity Pathway Analysis (IPA) was used to visualise networks of differentially expressed genes (n=12 per group). Serum samples were analysed using multiplexing technology (Luminex xMAP). Of 1644 differentially expre...
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: C. Delles, M.U. Moreno, C. Taurino, U. Neisius, W.M. Miller, J.D. McClure, M.W. McBride, A.F. Dominiczak Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

RISK PREDICTION IN CORONARY HEART DISEASE AND OTHER CONDITIONS: CURRENT UNCERTAINTIES AND FUTURE OPPORTUNITIESemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Risk prediction models are used to estimate individuals’ likelihood of future disease. Taking into account factors such as personal and family history, lifestyle, physical examination findings, and genetic and molecular biomarkers, risk prediction models apply a mathematical algorithm to estimate the risk of developing a particular outcome. Many models already exist, for conditions such as cardiovascular disease, type 2 diabetes and breast cancer.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: T.H.S. Dent, C.F. Wright Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

THE COMMON FUNCTIONAL ARG399GLN VARIANT IN THE DNA REPAIR ENZYME XRCC1 IS ASSOCIATED WITH ELEVATED LEVELS OF MICRONUCLEUS CHROMOSOMAL DNA DAMAGE AND SHORTER TELOMERE LENGTH IN PATIENT WITH ATHEROSCLEROSISemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Background: DNA repair is a key factor for maintaining genomic stability, including telomere maintenance. Telomere shortening and chromosomal DNA damage in circulating leucocytes have been shown to be associated with coronary artery disease (CAD).
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: C. Federici, S. Manfredi, M. Del Fiandra, K. Salpea, C. Maubaret, S.E. Humphries, M.G. Andreassi Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

CORONARY ARTERY DISEASE SUSCEPTIBILITY LOCUS ON CHROMOSOME 9P21email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
In conclusion, expression of ANRIL as well as of splice-variants appears to be cell-type-specific. Recent evidence suggests that expression may be haplotype-specific . Analysis of all possible transcripts using the tiling arrays will provide a full picture of ANRIL expression in cell-types relevant to CAD, as well as uncovering haplotype-specific effects, and provide further clues as to the functional role of ANRIL in CAD.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: L.D. Beeton, B. Burch, K. Russell, S. Salvage, P. Chivers, K.E. Webb Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

LRP5 VARIANTS ARE ASSOCIATED WITH TRIGLYCERIDE LEVELS AND TYPE 2 DIABETESemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Background and aims: The LDL-receptor related protein 5 (LRP5) gene is located on chromosome 11q13, a region that has been linked to type 1 diabetes (T1D). Lrp5−/− mice develop glucose intolerance, and increased cholesterol levels. The aim of this study was to evaluate the effect of LRP5 SNPs on lipid parameters and cardiovascular and T2D disease risk in a large prospective study.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: M. Guardiola, G. Ken-Dror, S.E. Humphries, P.J. Talmud Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

PHARMACOGENETICS OF STATIN TREATMENT: IMPACT OF APOA5, APOE, CYP7A1 AND HEPATIC LIPASE VARIANTSemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Background: Statins are drugs of choice in patients with high cholesterol levels and at increased CVD risk. There exists a significant inter-individual variability of statin efficacy that is likely to have a genetic basis. Apolipoproteins (APO) A5 and E, cholesterol 7-α-alpha-hydroxylase (CYP7A1) and hepatic lipase (HL) genes are the candidates that may play a role in modifying the therapeutic response to statins.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: J.A. Hubáèek, V. Adámková, R. Èeška, M. Vrablík Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

FTO POLYMORPHISM IS ASSOCIATED WITH MYOCARDIAL INFARCTIONemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Introduction: Myocardial infarction (MI) is the most common cause of death in industrial countries. All general MI risk factors have some genetic components and the proportion of genetic predisposition is between 30 and 60%. FTO gene (“fat mass and obesity related gene”, DNA demethylase) and its variants have been described primarily like important determinant of body weight. Further, FTO SNP increases general mortality independent of fatness in men. The association between FTO SNP rs17817449 and risk of MI development on middle European Caucasians was analysed.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: J.A. Hubáèek, V. Adámková, V. Stanìk, R. Poledne, M. Aschermann, J. Matoušková, M. Pìnièka, J. Veselka, J. Pitha Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

LOCAL POLYMORPHISMS INFLUENCE STK39 GENE EXPRESSION BUT ARE NOT ASSOCIATED WITH BLOOD PRESSUREemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Background: Blood pressure (BP) has significant heritability, but the genes responsible remain largely unknown. Single nucleotide polymorphisms (SNPs) in the STK39 gene were recently associated with hypertension by genome-wide association in an Amish population; in vitro data from transient transfection experiments using reporter constructs suggested that altered STK39 expression might mediate the effect. However, other large studies have not implicated STK39 in hypertension. We determined whether reported SNPs influenced STK39 expression in vivo, or were associated with BP in a large British Caucasian cohort.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: C. Kay, M.S. Cunnington, P. Avery, M. Santibanez-Koref, B. Keavney Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

−203A/C POLYMORPHISM OF CHOLESTEROL 7ALPHA-HYDROXYLASE (CYP7A1) GENE AND DIURNAL VARIATION IN CYP7A1 ACTIVITYemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The −203A/C polymorphism of cholesterol 7alpha-hydroxylase (CYP7A1) gene, the key regulatory enzyme in bile salt synthesis, affects responsiveness of serum cholesterol to dietary fat and cholesterol. However, no relationship between enzyme activity and this polymorphism has been demonstrated so far. Therefore, we studied whether this polymorphism can affect the diurnal variation of CYP7A1 activity.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: J. Kovar, M. Zimolova, M. Lenicek, L. Vitek, M. Jirsa, R. Poledne Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

PRO-PROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE9 (PCSK9) VARIANT DATABASE: PRELIMINARY ANALYSISemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This study aims to place all published PCSK9 variants in a publicly available database and assess the potential biological significance of each variant.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: S.E. Leigh, T. Jakubcova, R.A. Whittall, S.E. Humphries Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

DOWN-REGULATION OF ACE EXPRESSION IN HUVECS USING siRNA RESULTS IN DOWN-REGULATION OF UCP2 EXPRESSION: A POTENTIAL MECHANISM OF THE CLINICAL BENEFIT OF ACE-INHIBITORS?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Background: An intrinsic deficiency of fatigue-resistance and endurance performance of skeletal muscle is responsible for much of the symptomatic limitation attributed to chronic heart failure (CHF). This impaired performance is caused, in part, by defects in muscle metabolic efficiency. Angiotensin-converting enzyme (ACE) inhibitors are known to improve the condition of patients. We have used a cell approach and small interfering (si)RNAs to explore the hypothesis that reducing ACE activity leads to diminution of expression of the uncoupling protein-2 (UCP2). We also evaluated the effect of down-regulation of UCP2 on the level of ACE mRNA.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: C.G. Maubaret, R. Heads, S. Dhamrait, H. Montgomery, S.E. Humphries Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

CO-SEGREGATION OF EL AND HL VARIANTS WITH HIGH PLASMA HDL-C LEVELS IN FAMILIES WITH HYPERALPHALIPOPROTAEINEMIAemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Rational and results: To identify genetic causes of hyperalphalipoproteinemia and their pattern of inheritance, four candidate genes – CETP, SR-B1, EL and HL – were sequenced in 41 individuals with plasma HDL-c levels above the 95th percentile for age and gender. In 2 subjects, heterozygosity for a frameshift mutation (p.L130fsX165) and a missense change (p.R476W) in EL was identified. In 2 other individuals, we identified heterozygosity for 2 HL missense changes (p.Q369R and p.S289F). In co-segregation studies, 2 out of 12 carriers of the p.L130fsX165 did not show High HDL-c phenotype while 5 out of 17 non-carriers in...
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: M.M. Motazacker, A.G. Holleboom, R. Franssen, J. Azevedo, G.K. Hovingh, J.J.P. Kastelein, J.A. Kuivenhoven Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

GENOTYPES AT MATRIX METALLOPROTINASE (MMP) LOCI FOR MMP7, MMP9 AND MMP12 ARE ASSOCIATED WITH CAROTID IMT AND PRESENCE OF PLAQUESemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The aim of the study was to determine the association between metalloproteinase (MMP) polymorphisms with intima-media thickness in the common carotid (IMTcc) and presence of plaques in the common carotid and femoral bifurcations.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: A. Panayiotou, N. Georgiou, M. Griffin, D. Bond, T. Tyllis, S.E. Humphries, A.N. Nicolaides Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

IDENTIFICATION OF GENES ASSOCIATED WITH QT INTERVAL USING THE 50K CARDIO-METABOLIC SNP CHIP: RESULTS FROM THE WHITEHALL II STUDYemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Background: The QT interval on an electrocardiogram is a measure of the total time from ventricular depolarization to repolarization. QT interval, a heritable quantitative trait, and its prolongation by drugs, cardiac disease and electrolyte abnormalities are associated with the risk of developing ventricular arrhythmias and sudden cardiac death.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: S. Shah, F. Drenos, T. Shah, J. Palmen, C. Vezzili, R. Sofat, M. Kumari, M. Kivamaki, J. Pallas, P. MacFarlane, J. Whittaker, P.J. Talmud, S.E. Humphries, A.D. Hingorani Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

CONSIDERATION OF ETHNICITY IN CORONARY RISK PREDICTION USING CRPemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Rationale: CRP cut-points for the evaluation of CHD risk are mainly based on studies in Europeans. We evaluated CRP concentration in populations of differing geographical and ancestral background to consider the implications for risk prediction in non-European populations.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: T. Shah, P. Newcombe, J. Addo, J.P. Casas, L. Smeeth, J. Whittaker, A.D. Hingorani Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

THE KIF6 719ARG ALLELE IS ASSOCIATED WITH INCREASED RISK OF CORONARY HEART DISEASE AMONG MALES IN THE WELCOME TRUST CASE CONTROL CONSORTIUM STUDY OF CORONARY HEART DISEASEemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Carriers of the KIF6 719Arg allele, compared with noncarriers, have a higher risk of coronary heart disease (CHD) in several prospective studies and in the placebo groups of two randomized trials of pravastatin. In these trials, pravastatin treatment ameliorated the risk associated with 719Arg allele. In the Welcome Trust Case-Control Consortium (WTCCC) CHD study, although no association was observed between the 719Arg allele and CHD, a significant association between the 719Arg allele and CHD was observed in a sex-differentiated test. In order to investigate this sex-differentiated association, we analyzed the association...
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: D. Shiffman, C.M. Rowland, J. Thompson, A.S. Hall, J.J. Devlin, N.J. Samani Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

DIFFERENTIAL EFFECTS OF RADIAL ARTERY INJURY AND LIMB ISCHAEMIA ON CIRCULATING CD133+/CD34+ PROGENITOR CELLSemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Study rationale: Bone marrow derived progenitor cells increase after cardiovascular events, but may be reduced with atherosclerosis. They may be mobilised from the bone marrow in response to cytokines and ischaemia. We used a novel model of transient endothelial injury in healthy volunteers to contrast acute effects of mechanical injury with those of ischaemia/reperfusion on CD34+/133+ circulating progenitor cells.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: L.M. Tilling, M.V. Holmes, A. Verma Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

HEPATIC GENE EXPRESSION IN PRAGUE HEREDITARY HYPERCHOLESTEROLEMIC (PHHC) RATemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Prague hereditary hypercholesterolemic (PHHC) rat develops hypercholesterolemia after feeding cholesterol without an addition of cholic acid. The hypercholesterolemia is due to accumulation of cholesterol-rich VLDL and IDL in circulation.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: M. Zimolova, J. Kovar, R. Bohuslavova, V. Stranecky, R. Ivanek, M. Jirsa, R. Poledne Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

APOLIPOPROTEIN A1 GENE POLYMORPHISM (G-75A AND C+83T) IN MYOCARDIAL INFARCTION—A PILOT STUDY IN THE NORTH INDIAN POPULATIONemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Rationale of study: Coronary artery disease is assuming epidemic proportion in India as well as globally . Assessment of metabolic and lifestyle risk factors of atherosclerosis and interventions in these has, however, been ineffective in completely predicting or controlling the development of atherosclerotic process, suggesting that specific genetic predisposition should be considered . Since HDL and its Apolipoprotein A1 is mainly responsible for reverse cholesterol transport , we tried to study whether genetic polymorphism in ApoA1 gene (G-75A and C+83T) could be playing a role in occurrence of Myocardial Infarction.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: R. Dawar, A. Gurtoo, R. Singh Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

ROLE OF COAGULATION FACTORS IN CORONARY THROMBOSIS IN YOUNG INDIVIDUALS—A HOSPITAL BASED STUDYemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Myocardial infarction (MI) is a leading cause of death and disability worldwide, with genetic and environmental predisposition. Majority of myocardial infarctions occur in individuals >65 years old, but is being increasingly seen in individuals with age
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: S. Dayakar, S. Komandur, M.d. Sadhnani, V. Bhupesh Kumar, P. Sreedhar, Sudhir Naik, P. Seshargiri Rao, P.C. Rath, Narsa Raju, K. Manoj Agarwal, B. Shyamala Sesikeran Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

ANGPTL3 VARIATION IN TYPE 2 DIABETESemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Introduction: ANGPTL3 is involved in the regulation of lipid metabolism and has recently been implicated in the pathogenesis of T2D in mice. We investigated the effect of common variation of this gene on T2D risk and risk factors, as well as the association with the protein serum levels.
Source: Atherosclerosis - November 1, 2009 Category: Cardiology Authors: K.D. Salpea, J.A. Cooper, P.J. Talmud, S.E. Humphries Tags: BAS Autumn Meeting 2009 Abstracts Source Type: journals

Adult Congenital Patients in the Hospital—Where the Rubber Meets the Roademail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Congenital Heart Disease - November 1, 2009 Category: Cardiology Authors: Douglas Moodie Tags: EDITORIAL Source Type: journals

Migraine Tied to CV Complicationsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
PHILADELPHIA — Migraine with or without aura was associated with a significant increase in the risk of cardiovascular disease, including stroke and heart attack, in a population-based study that included more than 6,000 U.S. adults with migraine.
Source: Cardiology News - November 1, 2009 Category: Cardiology Authors: MICHELE G. SULLIVAN Tags: News Source Type: news

Stenting Effective For Left Main Disease in ACS: Common strategy for sickest patients.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
BARCELONA — Coronary artery stenting is used increasingly to treat the sickest patients with acute coronary syndrome, and the 180-day outcomes have been reasonable, with 80% of these patients surviving for 6 months beyond their initial hospitalization, based on data from almost 1,800 registry patients.
Source: Cardiology News - November 1, 2009 Category: Cardiology Authors: MITCHEL L. ZOLER Tags: News Source Type: news

Research Into Cardiac Stem Cells at Crossroadsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
BETHESDA, MD. — It may be time for a retrenching in basic science when it comes to the use of stem cells to treat heart disease. That was the consensus expressed by prominent researchers at a National Heart, Lung, and Blood Institute–sponsored symposium last month.
Source: Cardiology News - November 1, 2009 Category: Cardiology Authors: ALICIA AULT Tags: News Source Type: news

Mission: Lifelineemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Dr. Goldstein, medical editor of Cardiology News, is professor of medicine at Wayne State University and division head emeritus of cardiovascular medicine at Henry Ford Hospital, both in Detroit.
Source: Cardiology News - November 1, 2009 Category: Cardiology Authors: SIDNEY GOLDSTEIN Tags: Heart of the Matter Source Type: news

Vital Signs: Top 10 Corporations by Dispensed Prescriptions, 2008email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Cardiology News - November 1, 2009 Category: Cardiology Tags: News Source Type: news

Bromocriptine Reversed PPCM in Small Trialemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
BARCELONA — Adding bromocriptine to standard heart failure therapy in women with peripartum cardiomyopathy improved survival and produced major gains in left ventricular systolic and diastolic function in the first-ever randomized trial of this novel therapy.
Source: Cardiology News - November 1, 2009 Category: Cardiology Authors: BRUCE JANCIN Tags: News Source Type: news

Meta-Analysis: Targeted PAH Therapies Cut Mortality 43%email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
BARCELONA — Targeted therapies for pulmonary arterial hypertension collectively reduced all-cause mortality by 43% compared with placebo, in a meta-analysis of the randomized, placebo-controlled, clinical trials conducted during the past 18 years.
Source: Cardiology News - November 1, 2009 Category: Cardiology Authors: BRUCE JANCIN Tags: News Source Type: news

Heart Failure Patients Need Better Flu Protectionemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
BOSTON — Patients with heart failure do not maintain protective levels of antibody titres following influenza vaccination, leaving this already at-risk population even more vulnerable to influenza-related complications, according to a study presented at the annual scientific meeting of the Heart Failure Society of America.
Source: Cardiology News - November 1, 2009 Category: Cardiology Authors: DIANA MAHONEY Tags: News Source Type: news

Fractional Flow Reserve as PCI Guide Costs Lessemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
BARCELONA — Using fractional flow reserve to guide coronary stenting produced a sizeable reduction in treatment costs during the year afterward in a randomized study with about 1,000 patients.
Source: Cardiology News - November 1, 2009 Category: Cardiology Authors: MITCHEL L. ZOLER Tags: Interventional Cardiology Source Type: news

Doubling Clopidogrel Aids Stented ACS Patients: In CURRENT-OASIS7, 600-mg loading dose cut ischemic and thrombotic events, increased bleeding.email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
BARCELONA — Doubling the clopidogrel dosage for a week following coronary artery stenting led to significantly fewer thrombotic events and a small increase in bleeds in a major study of more than 25,000 acute coronary syndrome patients.
Source: Cardiology News - November 1, 2009 Category: Cardiology Authors: MITCHEL L. ZOLER Tags: Interventional Cardiology Source Type: news

Novel Drug Cuts Acute MIs in Selected Patientsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
BARCELONA — Ivabradine reduced hospitalizations for acute MI by 73% in patients with stable coronary artery disease and left ventricular systolic dysfunction who had limiting angina and a baseline resting heart rate of 70 bpm or more, according to a new analysis from the BEAUTIFUL trial.
Source: Cardiology News - November 1, 2009 Category: Cardiology Authors: BRUCE JANCIN Tags: Cad & Atherosclerosis Source Type: news

Allopurinol for Angina Improves Exercise Timeemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
BARCELONA — Allopurinol treatment for 6 weeks significantly improved symptoms of chronic, stable angina in a randomized, placebo-controlled, crossover study of 60 patients. Allopurinol administered at labeled dosages produced three significant improvements during an exercise treadmill test, which were the study's primary end points: increased total exercise time, increased time to ST-segment depression, and increased time to angina, Dr. Awsan Noman said at the annual congress of the European Society of Cardiology.
Source: Cardiology News - November 1, 2009 Category: Cardiology Authors: MITCHEL L. ZOLER Tags: Cad & Atherosclerosis Source Type: news

Psoriasis Not Linked to CV Hospitalizationsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
BUDAPEST — The last word on the relationship between psoriasis and cardiovascular disease may not be in, according to the results of a new study. Contrary to earlier studies, psoriasis was found to not be an independent risk factor for hospitalization for ischemic heart disease in a large Dutch study, Dr. Marlies Wakkee reported at the annual congress of the European Society for Dermatological Research.
Source: Cardiology News - November 1, 2009 Category: Cardiology Authors: BRUCE JANCIN Tags: Epidemiology & Prevention Source Type: news

MI, Stroke Risk Soars With Lupus Anticoagulantemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The presence of lupus anticoagulant, an antiphospholipid antibody, increased the risk of stroke by 40-fold and of heart attack by 5-fold in a Dutch study that compared young women who had survived these conditions with a healthy control group.
Source: Cardiology News - November 1, 2009 Category: Cardiology Authors: JANE SALODOF MacNEIL Tags: Epidemiology & Prevention Source Type: news

Diabetes Raises A-Fib Risk, but Just in Womenemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
VIENNA — Diabetes was a significant risk factor for atrial fibrillation among women but not men in an analysis of electronic medical records from a large HMO database. The study also found that both the prevalence and the incidence of atrial fibrillation (AF) were more than 40% higher among patients with diabetes than in those without. After the researchers accounted for other risk factors, diabetes increased the risk for AF by 16%, Gregory A. Nichols, Ph.D., said in an interview prior to his presentation of the findings at the annual meeting of the European Association for the Study of Diabetes.
Source: Cardiology News - November 1, 2009 Category: Cardiology Authors: MIRIAM E. TUCKER Tags: Arrhythmias & Electrophysiology Source Type: news

Statin Is Mildly Protective Against AF in Heart Failureemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
BARCELONA — Rosuvastatin exerted a “modest” preventive effect against the occurrence of atrial fibrillation in patients with chronic heart failure, according to a secondary analysis of the Italian GISSI-Heart Failure study.
Source: Cardiology News - November 1, 2009 Category: Cardiology Authors: BRUCE JANCIN Tags: Arrhythmias & Electrophysiology Source Type: news

Quick ICD Post MI Raises Nonsudden Cardiac Deathemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Placement of an implantable cardioverter defibrillator immediately following a myocardial infarction didn't reduce mortality in patients at high risk for arrhythmia in a randomized trial.
Source: Cardiology News - November 1, 2009 Category: Cardiology Authors: MARY ANN MOON Tags: Arrhythmias & Electrophysiology Source Type: news

Erythropoietin May Improve HF-Related Anemiaemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
BARCELONA — Erythropoietin therapy in patients with anemia of heart failure resulted in improved exercise capacity, reduced heart failure symptoms, and decreased hospitalizations, and showed strong trends for reduced rates of MI and all-cause mortality in a meta-analysis of 11 small randomized clinical trials.
Source: Cardiology News - November 1, 2009 Category: Cardiology Authors: BRUCE JANCIN Tags: Heart Failure Source Type: news

Process-of-Care Intervention Improves Outpatient HF Careemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
BOSTON — Pperformance improvement intervention for outpatient care of heart failure patients increases the use of evidence-based, guideline-recommended processes and therapies, Dr. Clyde W. Yancy said at the annual meeting of the Heart Failure Society of America.
Source: Cardiology News - November 1, 2009 Category: Cardiology Authors: DIANA MAHONEY Tags: Heart Failure Source Type: news

Trials Need to Include More Hispanics to Unravel Paradoxemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
CHICAGO — Despite the underrepresentation of Hispanics in heart failure trials, evidence has emerged suggesting that they have unique risk factors and outcomes that must be taken into clinical consideration.
Source: Cardiology News - November 1, 2009 Category: Cardiology Authors: PATRICE WENDLING Tags: Heart Failure Source Type: news

ICDs Don't Save Women With Heart Failureemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Implantable cardioverter defibrillators do not reduce all-cause mortality in women who have advanced heart failure, unlike in men, according to a meta-analysis. “ICDs are being implanted in hundreds of thousands of women without substantial evidence of benefit, apparently based on the assumption that, to paraphrase the old saying, ‘What's good for the gander is good for the goose,’” Dr. Rita F. Redberg said in an accompanying editorial (Arch. Intern. Med. 2009;169:1460–1).
Source: Cardiology News - November 1, 2009 Category: Cardiology Authors: MARY ANN MOON Tags: Heart Failure Source Type: news

Initiative Speeds Reperfusion Treatment Timeemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
BOSTON — A statewide program to get patients with severe heart attacks to hospitals faster significantly reduced disparities in reperfusion treatment times for women and elderly patients, based on a study of more than 900 patients in North Carolina.
Source: Cardiology News - November 1, 2009 Category: Cardiology Authors: HEIDI SPLETE Tags: Acute Coronary Syndromes Source Type: news

Sulfonylureas Tied to Mortality in MI Survivorsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
BARCELONA — Four widely prescribed oral sulfonylurea drugs are associated with significantly increased risk of all-cause mortality compared with metformin in type 2 diabetic patients having a history of MI, according to a comprehensive Danish national cohort study.
Source: Cardiology News - November 1, 2009 Category: Cardiology Authors: BRUCE JANCIN Tags: Acute Coronary Syndromes Source Type: news

Heart Defect Screening Indicated in Turner'semail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
NEW YORK — Partial anomalous pulmonary venous return was detected by cardiac magnetic resonance imaging in 7 of 39 adolescent and young adult women with Turner's syndrome whose charts were retrospectively evaluated.
Source: Cardiology News - November 1, 2009 Category: Cardiology Authors: MIRIAM E. TUCKER Tags: Congenital Heart Diseases Source Type: news

Policy & Practiceemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Can't get enough Policy & Practice? Check out our new podcast each Monday. egmnblog.wordpress.com The American Medical Association's Current Procedural Terminology (CPT) panel has approved four new Category 1 codes for cardiac computed tomography, which replace current Category III codes. The new codes were the result of a joint effort by professional societies including the American College of Radiology and the Society of Cardiovascular Computed Tomography. The codes will go into effect Jan. 1, 2010. They are 75571 (calcium scoring), 75572 (pulmonary veins), 75573 (congenital heart disease), and 75574 (coronary CT angiog...
Source: Cardiology News - November 1, 2009 Category: Cardiology Authors: Alicia Ault Tags: Practice Trends Source Type: news

Feds Issue Rules for Use of Genetic Information by Insurersemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The federal government has issued new rules spelling out how it intends to police the use of genetic information by health plans. The regulations bar health insurers from increasing premiums or denying enrollment based on genetic information. The regulations implement certain provisions in the Genetic Information Nondiscrimination Act (GINA), which was signed into law by President Bush in May 2008.
Source: Cardiology News - November 1, 2009 Category: Cardiology Authors: MARY ELLEN SCHNEIDER Tags: Practice Trends Source Type: news

Data Watch: Medicare, Medicaid Stays Account for 60% of Hospital Costsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Cardiology News - November 1, 2009 Category: Cardiology Tags: Practice Trends Source Type: news