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This page shows you the most recent publications within this specialty of the MedWorm directory. This is page number 3.

Normal systolic blood pressure and risk of heart failure in US male physiciansemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion Our findings suggest a linear relationship between normotensive SBP and HF risk. Strategies to prevent HF, such as lifestyle modification, should be emphasized across all blood pressure ranges.
Source: European Journal of Heart Failure - November 19, 2009 Category: Cardiology Authors: Britton, K. A., Gaziano, J. M., Djousse, L. Tags: EPIDEMIOLOGY Source Type: journals

Heart failure in patients hospitalized with acute coronary syndromes: observations from the Gulf Registry of Acute Coronary Events (Gulf RACE)email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusion Heart failure complicates a substantial proportion of ACS admissions in the Arab Middle East and is associated with higher in-hospital death. Younger patients with ACS have a higher relative increase in mortality related to HF.
Source: European Journal of Heart Failure - November 19, 2009 Category: Cardiology Authors: Alsheikh-Ali, A. A., Al-Mallah, M. H., Al-Mahmeed, W., Albustani, N., Al Suwaidi, J., Sulaiman, K., Zubaid, M., for the Gulf RACE Investigators Tags: EPIDEMIOLOGY Source Type: journals

Oral anticoagulants REDEEMed? Daily dabigatran "safe" with dual antiplatelets after MIemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
A dose-finding study saw what were characterized as low bleeding rates associated with triple-drug antithrombotic therapy that included the oral anticoagulant dabigatran in patients with a recent ACS event and other cardiovascular risk factors.
Source: theHeart.org - November 19, 2009 Category: Cardiology Source Type: info

CMS' reimbursements for PET MPI to increaseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The Centers for Medicaid & Medicare Services (CMS) will increase the reimbursement for PET myocardial perfusion imaging (MPI) by 24 percent in 2010.
Source: Cardiovascular Business News - November 19, 2009 Category: Cardiology Tags: Latest News Source Type: news

CMS increases PET MPI reimbursementemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The Centers for Medicaid & Medicare Services (CMS) will increase the reimbursement for PET myocardial perfusion imaging (MPI) by 24 percent in 2010.
Source: Cardiovascular Business News - November 19, 2009 Category: Cardiology Tags: Latest News Source Type: news

AHA: Newer Anticoagulants Beat Heparin for PCI (CME/CE)email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
ORLANDO (MedPage Today) -- Acute myocardial infarction patients pretreated with anticoagulants before percutaneous coronary interventions appear to fare better with fondaparinux or enoxaparin than unfractionated heparin, researchers reported.
Source: MedPage Today Cardiovascular - November 19, 2009 Category: Cardiology Source Type: news

EFFECT: Public reporting of hospital performance improves quality of care?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Publicly released report cards based on hospital performance did not result in a measurably greater systemwide improvement in two composite AMI or CHF process-of-care indicators in a Canadian study. But they did appear to stimulate some important changes in delivery of care that could have led to some better outcomes.
Source: theHeart.org - November 19, 2009 Category: Cardiology Source Type: info

AHA: While on statins, better to also raise HDL and not just lower LDL levelsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Orlando, Fla.—The use of statins to reduce LDL-C is more effective with the subsequent addition of extended-release niacin (Niaspan; Abbott), which lowers LDL plus increases HDL, compared with the subsequent administration of ezetimibe (Zetia; Merck) in reducing the progression of atherosclerosis, according to the ARBITER 6-HALTS trial presented Monday at the American Heart Association (AHA) conference.
Source: Cardiovascular Business News - November 19, 2009 Category: Cardiology Tags: Latest News Source Type: news

Study Supports Use Of MTWA Test As Predictor Of Sudden Cardiac Deathemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Cambridge Heart, Inc. (OTCBB-CAMH), announced that results of the PREVENT-SCD trial, presented at the American Heart Association Scientific Sessions in Orlando, Florida, reinforce the value of the Microvolt T-wave Alternans (MTWA) test in identifying patients at risk of sudden cardiac death (SCD).
Source: Cardiovascular / Cardiology News From Medical News Today - November 19, 2009 Category: Cardiology Tags: Cardiovascular / Cardiology Source Type: news

HEAAL: High-dose beats low-dose losartan in HFemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Patients treated with a high, 150-mg daily dose of the angiotensin-receptor blocker losartan had a significantly reduced risk for death or hospitalization for heart failure compared with patients taking a 50-mg daily dose of the drug, the HEAAL investigators report.
Source: MedWire News - Cardiology - November 19, 2009 Category: Cardiology Source Type: news

Inside This Issueemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
1993 Joseph D. Mishkin, Sherry J. Saxonhouse, Gregory W. Woo, Thomas A. Burkart, William M. Miles, Jamie B. Conti, Richard S. Schofield, Samuel F. Sears, Juan M. Aranda, Jr
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Tags: Frontmatter Source Type: journals

2009 ACCF/AHA Focused Update on Perioperative Beta Blockade Incorporated Into the ACC/AHA 2007 Guidelines on Perioperative Cardiovascular Evaluation and Care for Noncardiac Surgeryemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Kirsten E. Fleischmann, MD, MPH, FACC, Chair Joshua A. Beckman, MD, FACC
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Lee A. Fleisher, Joshua A. Beckman, Kenneth A. Brown, Hugh Calkins, Elliot L. Chaikof, Kirsten E. Fleischmann, William K. Freeman, James B. Froehlich, Edward K. Kasper, Judy R. Kersten, Barbara Riegel, John F. Robb, American College of Cardiology Foundati Tags: ACCF/AHA PRACTICE GUIDELINES: FULL TEXT Source Type: journals

Anemia in Adults With Congenital Heart Disease Relates to Adverse Outcomeemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Objectives: To assess the relation of anemia in noncyanotic adults with congenital heart disease (ACHD) to functional capacity and mortality.Background: Anemia is common in acquired heart failure and affects prognosis. The presence of anemia and its relation to outcome in ACHD remain unknown.Methods: Data were collected on consecutive noncyanotic ACHD patients attending our tertiary center between 2001 and 2006 in whom hemoglobin concentration was measured. Anemia was defined as hemoglobin concentration
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Konstantinos Dimopoulos, Gerhard-Paul Diller, Georgios Giannakoulas, Ricardo Petraco, Aikaterini Chamaidi, Evaggelia Karaoli, Michael Mullen, Lorna Swan, Massimo F. Piepoli, Philip A. Poole-Wilson, Darrel P. Francis, Michael A. Gatzoulis Tags: CONGENITAL HEART DISEASE Source Type: journals

Coronary Artery Aneurysm Formation Within New-Generation Bare-Metal Stents: Not Just Due to Drug Elution!email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
A 57-year-old woman with chronic stable angina underwent uncomplicated stenting in the left anterior descending artery (LAD) and right coronary artery (RCA) (A) with excellent results in the target vessel. Coronary angiogram repeated for atypical chest pain 6 months later demonstrated coronary artery aneurysm (CAA) (arrowheads) within the segments stented with a bare-metal stent (BMS) in both arteries (B), confirmed on intravascular ultrasound examination (C). Arrows show the extent of the aneurysm as seen on the intravascular ultrasound images. The RCA segment stented with the everolimus-eluting stent Xience (Abbott Labor...
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Sudipta Chattopadhyay, Timothy Kinnaird, Richard A. Anderson Tags: IMAGES IN CARDIOLOGY Source Type: journals

2009 ACCF/AHA Focused Update on Perioperative Beta Blockadeemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Lee A. Fleisher, MD, FACC, FAHA, Chair Joshua A. Beckman, MD, FACC
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Kirsten E. Fleischmann, Joshua A. Beckman, Christopher E. Buller, Hugh Calkins, Lee A. Fleisher, William K. Freeman, James B. Froehlich, Edward K. Kasper, Judy R. Kersten, John F. Robb, R. James Valentine, American College of Cardiology Foundation, Americ Tags: ACCF/AHA PRACTICE GUIDELINES: FOCUSED UPDATE Source Type: journals

The Role of Ganglionated Plexi in Apnea-Related Atrial Fibrillationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: This experimental model of apnea shows a reproducible incidence of AF. After neural ablation of the RPA GP or autonomic blockade, AF inducibility was significantly inhibited.
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Muhammad Ghias, Benjamin J. Scherlag, Zhibing Lu, Guodong Niu, Annerie Moers, Warren M. Jackman, Ralph Lazzara, Sunny S. Po Tags: QUARTERLY FOCUS ISSUE: HEART RHYTHM DISORDERS Source Type: journals

Sleep Apnea and Atrial Fibrillation: The Autonomic Link⁎email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The intuitive and postulated links () between the established association of obstructive sleep apnea with atrial fibrillation (AF) are hypertension, diastolic dysfunction, and the resultant long-term atrial remodeling (). However, studies suggest that the relationship between sleep apnea and AF is independent of hypertension, cardiac function, or body mass index. Further, untreated sleep apnea doubles the risk of AF recurrence within 12 months of cardioversion independent of other risk factors (). Thus, is the relationship between sleep apnea and AF an epiphenomenon, or is it truly causative and the linking mechanism is si...
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Samuel J. Asirvatham, Suraj Kapa Tags: Editorial Comment Source Type: journals

A Meta-Analysis of the Mechanism of Blood Pressure Change With Agingemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: These findings challenge the current consensus view that a shift in timing of wave reflection significantly contributes to the changes in the BP waveform with aging. We should re-evaluate the mechanisms of BP elevation in aging.
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Arun J. Baksi, Thomas A. Treibel, Justin E. Davies, Nearchos Hadjiloizou, Rodney A. Foale, Kim H. Parker, Darrel P. Francis, Jamil Mayet, Alun D. Hughes Tags: HYPERTENSION Source Type: journals

Genotype–Phenotype Relationship in the Long QT Syndrome: Brimming With Knowledge but Thirsting for a Therapeutic Solution⁎email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Since it was first reported 50 years ago, the long QT syndrome (LQTS) is now recognized as a genetic disease caused by mutations of ion channel genes encoding a cardiac channel essential for the control of ventricular repolarization (). The LQTS is not only the most common and extensively researched genetic cardiac arrhythmia (), it has also attracted premier scientists and scholars in single-cell electrophysiology and molecular genetics. In turn, they have produced seminal discoveries that shaped our understanding of the syndrome. The mutated genes in LQTS patients cause delayed repolarization and, in turn, prolong the QT...
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Koonlawee Nademanee Tags: Editorial Comment Source Type: journals

The RYR2-Encoded Ryanodine Receptor/Calcium Release Channel in Patients Diagnosed Previously With Either Catecholaminergic Polymorphic Ventricular Tachycardia or Genotype Negative, Exercise-Induced Long QT Syndrome: A Comprehensive Open Reading Frame Mutational Analysisemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
This study was undertaken to determine the spectrum and prevalence of mutations in the RYR2-encoded cardiac ryanodine receptor in cases with exertional syncope and normal corrected QT interval (QTc).Background: Mutations in RYR2 cause type 1 catecholaminergic polymorphic ventricular tachycardia (CPVT1), a cardiac channelopathy with increased propensity for lethal ventricular dysrhythmias. Most RYR2 mutational analyses target 3 canonical domains encoded by
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Argelia Medeiros-Domingo, Zahurul A. Bhuiyan, David J. Tester, Nynke Hofman, Hennie Bikker, J. Peter van Tintelen, Marcel M.A.M. Mannens, Arthur A.M. Wilde, Michael J. Ackerman Tags: QUARTERLY FOCUS ISSUE: HEART RHYTHM DISORDERS Source Type: journals

Transesophageal Echocardiography Before Atrial Fibrillation Ablation: Looking Before Cooking⁎email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
In many electrophysiology laboratories, atrial fibrillation (AF) is becoming the most common heart rhythm disorder being treated with catheter ablation. Reasons for this include the large numbers of patients with AF, the poor quality of life commonly associated with AF, the limitations of drug therapy, advances in ablation tools and methods, and the increasing number of electrophysiologists trained in the technique. Catheter ablation is now recognized as a legitimate option for patients with symptomatic AF who have failed antiarrhythmic drug therapy ().
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Bradley P. Knight Tags: Editorial Comment Source Type: journals

A Comparison of Atrial Arrhythmias After Heart or Double-Lung Transplantation at a Single Center: Insights Into the Mechanism of Post-Operative Atrial Fibrillationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: In heart transplant recipients, AF is uncommon and occurs in the setting of myocardial dysfunction and graft rejection. In contrast, AF is more common after lung transplantation despite the absence of graft rejection and cardiac dysfunction. Pulmonary vein isolation alone cannot explain the discrepancy in AF incidence between heart transplant recipients and double-lung transplant recipients. Cardiac autonomic denervation may have a protective effect for heart transplant patients in the post-operative setting.
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: José Dizon, Kimberly Chen, Matthew Bacchetta, Michael Argenziano, Donna Mancini, Angelo Biviano, Joshua Sonett, Hasan Garan Tags: QUARTERLY FOCUS ISSUE: HEART RHYTHM DISORDERS Source Type: journals

Atrial Fibrillation After Major Thoracic Surgery: New Insights Into Underlying Mechanisms⁎email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Atrial fibrillation (AF) is a common complication in patients undergoing major thoracic surgery (). It is most frequently observed acutely after valve surgery and/or coronary artery bypass graft surgery (CABG), but it can also manifest after lung and heart transplantation procedures (). Although mechanisms underlying this unique form of AF have not been adequately elucidated, it is likely that these involve a combination of pericardial inflammation, myocardial ischemia, catecholamine surge, autonomic imbalance, interstitial fluid mobilization, tissue rejection, and so forth (). It is interesting to note that AF is observed...
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Sanjay Dixit Tags: Editorial Comment Source Type: journals

Genotype-Phenotype Aspects of Type 2 Long QT Syndromeemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: The KCNH2 missense mutations located in the transmembrane S5-loop-S6 region are associated with the greatest risk.
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Wataru Shimizu, Arthur J. Moss, Arthur A.M. Wilde, Jeffrey A. Towbin, Michael J. Ackerman, Craig T. January, David J. Tester, Wojciech Zareba, Jennifer L. Robinson, Ming Qi, G. Michael Vincent, Elizabeth S. Kaufman, Nynke Hofman, Takashi Noda, Shiro Kamak Tags: QUARTERLY FOCUS ISSUE: HEART RHYTHM DISORDERS Source Type: journals

Clinical Benefits of Remote Versus Transtelephonic Monitoring of Implanted Pacemakersemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: The strategic use of remote pacemaker interrogation follow-up detects actionable events that are potentially important more quickly and more frequently than transtelephonic rhythm strip recordings. The use of transtelephonic rhythm strips for pacemaker follow-up is of little value except for battery status determinations. (PREFER [Pacemaker Remote Follow-up Evaluation and Review]; NCT00294645)
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: George H. Crossley, Jane Chen, Wassim Choucair, Todd J. Cohen, Douglas C. Gohn, W. Ben Johnson, Eleanor E. Kennedy, Luc R. Mongeon, Gerald A. Serwer, Hongyan Qiao, Bruce L. Wilkoff, PREFER Study Investigators Tags: QUARTERLY FOCUS ISSUE: HEART RHYTHM DISORDERS Source Type: journals

Transtelephonic Versus Remote Monitoring of Cardiovascular Implantable Electronic Devices: Is One Approach to Be Preferred?⁎email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Intracardiac pacemaker implantation was first described a half century ago; the same authors first reported on transtelephonic monitoring (TTM) of such devices a dozen years later (). Follow-up of the pacemaker patient was recognized as critical, particularly in view of the uncertain reliability associated with leads and generators. Tracking device longevity and function have remained an important problem (), compounded by the development of more widespread indications for pacemakers (), increasingly complex devices, and mounting advisories that attest to an ever-present threat of premature device failure (). Ironically, t...
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Mark H. Schoenfeld Tags: Editorial Comment Source Type: journals

Atrial Fibrillation at Baseline and During Follow-Up in ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial)email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Objectives: The ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial) determined that treatment with amlodipine, lisinopril, or doxazosin was not superior to thiazide-like diuretic (chlorthalidone) in preventing coronary heart disease (CHD) or other cardiovascular events. This subanalysis examines baseline prevalence and in-trial incidence of new-onset atrial fibrillation (AF) or atrial flutter (AFL) and their influence on clinical outcomes.Background: Limited information is available on whether atrial fibrillation incidence is affected differentially by different classes of antihypertensive ...
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: L. Julian Haywood, Charles E. Ford, Richard S. Crow, Barry R. Davis, Barry M. Massie, Paula T. Einhorn, Angela Williard, ALLHAT Collaborative Research Group Tags: QUARTERLY FOCUS ISSUE: HEART RHYTHM DISORDERS Source Type: journals

Role of the CHADS2 Score in the Evaluation of Thromboembolic Risk in Patients With Atrial Fibrillation Undergoing Transesophageal Echocardiography Before Pulmonary Vein Isolationemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Objectives: The goals of this study were to determine: 1) if low-risk patients assessed by a CHADS2 score, a clinical scoring system quantifying a risk of stroke in patients with atrial fibrillation (AF), require a routine screening transesophageal echocardiogram (TEE) before pulmonary vein isolation (PVI); and 2) the relationship of a CHADS2 score with left atrial (LA)/left atrial appendage (LAA) spontaneous echo contrast, sludge, and thrombus.Background: There is no clear consensus of whether a screening TEE before catheter ablation of AF should be performed in every patient.Methods: Initial TEEs for pre-PVI of 1,058 AF ...
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Sarinya Puwanant, Brandon C. Varr, Kevin Shrestha, Sarah K. Hussain, W.H. Wilson Tang, Ruvin S. Gabriel, Oussama M. Wazni, Mandeep Bhargava, Walid I. Saliba, James D. Thomas, Bruce D. Lindsay, Allan L. Klein Tags: QUARTERLY FOCUS ISSUE: HEART RHYTHM DISORDERS Source Type: journals

Appropriate Evaluation and Treatment of Heart Failure Patients After Implantable Cardioverter-Defibrillator Discharge: Time to Go Beyond the Initial Shockemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Multiple clinical trials support the use of implantable cardioverter-defibrillators (ICDs) for prevention of sudden cardiac death in patients with heart failure (HF). Unfortunately, several complicating issues have arisen from the universal use of ICDs in HF patients. An estimated 20% to 35% of HF patients who receive an ICD for primary prevention will experience an appropriate shock within 1 to 3 years of implant, and one-third of patients will experience an inappropriate shock. An ICD shock is associated with a 2- to 5-fold increase in mortality, with the most common cause being progressive HF. The median time from initi...
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Joseph D. Mishkin, Sherry J. Saxonhouse, Gregory W. Woo, Thomas A. Burkart, William M. Miles, Jamie B. Conti, Richard S. Schofield, Samuel F. Sears, Juan M. Aranda Tags: State-of-the-Art Paper Source Type: journals

Implantable Cardioverter-Defibrillator Therapy After Acute Myocardial Infarction: The Results Are Not Shockingemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The risk of sudden death is highest early after myocardial infarction (MI) and progressively declines over the ensuing 6 to 12 months. Nevertheless, several randomized clinical trials have failed to show a survival benefit for implantable cardioverter-defibrillators when implanted early after MI in high-risk patients. The etiology of this acute MI–sudden cardiac death paradox is unclear, but may be related to the changing nature of the substrate over the several month period after acute MI. Further investigation is needed to delineate the actual causes of death in the early post-MI period and which interventions can be i...
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Jeffrey J. Goldberger, Rod Passman Tags: Viewpoint Source Type: journals

Women Have a Lower Prevalence of Structural Heart Disease as a Precursor to Sudden Cardiac Arrest: The Ore-SUDS (Oregon Sudden Unexpected Death Study)email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Conclusions: Women were significantly less likely than men to have a diagnosis of structural heart disease (LV dysfunction or coronary artery disease) before SCA. These findings suggest that fewer women may be eligible for prophylactic implantable cardioverter-defibrillator placement based on current guidelines and therefore may not have equal opportunity for prevention. Enhancement of SCA risk stratification may have even higher importance for women.
Source: Journal of the American College of Cardiology - November 19, 2009 Category: Cardiology Authors: Sumeet S. Chugh, Audrey Uy-Evanado, Carmen Teodorescu, Kyndaron Reinier, Ronald Mariani, Karen Gunson, Jonathan Jui Tags: Clinical Research Source Type: journals

AHA: Low Bleeding Rates Observed in Dabigatran Dose-Ranging Trial (CME/CE)email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
ORLANDO (MedPage Today) -- The oral anticoagulant dabigatran did not appear to markedly increase major bleeding rates among post-MI patients who were already being treated with aspirin and clopidogrel (Plavix), researchers said here.
Source: MedPage Today Cardiovascular - November 19, 2009 Category: Cardiology Source Type: news

PanGenex Expands Clinical Trial Sites After Promising Pre-Clinical Data About Lower Coronary Arterial Calcium Scores In Cardiac Patientsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
PanGenex Corporation (Pink Sheets: PGCX) ("PanGenex" or "the Company") announced that due to promising pre-clinical results from its clinical trial at the Cardiovascular Institute of the South (http://www.cardio.com/site1.php), the Company will extend its trial to two additional sites.
Source: Cardiovascular / Cardiology News From Medical News Today - November 19, 2009 Category: Cardiology Tags: Cardiovascular / Cardiology Source Type: news

Report: Most patients satisfied with U.S. inpatient hospital careemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Patient ratings of overall inpatient care in U.S. hospitals increased by 1.5 percent last year, with an increase in patients who said they would recommend the care to others, based on the findings of a report published by healthcare consulting firm Press Ganey.
Source: Cardiovascular Business News - November 19, 2009 Category: Cardiology Tags: Latest News Source Type: news

Can alcohol be good for you?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
We say there are limits to the health benefits of alcohol for the heart
Source: BHF National News - November 19, 2009 Category: Cardiology Source Type: consumer

Statins protect women from heart diseaseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Study shows statins protect women from heart disease as well as men
Source: BHF National News - November 19, 2009 Category: Cardiology Source Type: consumer

Results From Two Phase II Trials Add To Understanding Of Ticagrelor (BRILINTA(TM)) And How It Works In The Bodyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
AstraZeneca (NYSE: AZN) announced the results of the phase II studies, ONSET/OFFSET and RESPOND for ticagrelor (BRILINTA(TM)) at the annual American Heart Association (AHA) Scientific Sessions in Orlando, FL,(1,2) with ONSET/OFFSET study results being simultaneously published in the medical journal Circulation.(3) The ONSET/OFFSET data showed that treatment with ticagrelor (BRILINTA(TM)) achieved a more rapid onset of antiplatelet effect (41% IPA vs.
Source: Cardiovascular / Cardiology News From Medical News Today - November 19, 2009 Category: Cardiology Tags: Heart Disease Source Type: news

People With Type D Personalities Experience More Health Problemsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
People who experience a lot of negative emotions and do not express these experience more health problems, says Dutch researcher Aline Pelle. She discovered that heart failure patients with a negative outlook reported their complaints to a physician or nurse far less often. The personality of the partner can also exert a considerable influence on these patients. Aline Pelle investigated patients with a so-called type D personality.
Source: Cardiovascular / Cardiology News From Medical News Today - November 19, 2009 Category: Cardiology Tags: Psychology / Psychiatry Source Type: news

Hospital Report Cards Do Not Appear To Result In Significant Improvementsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
An analysis of quality of cardiac care following the public release of data on measures of care at hospitals in Ontario, Canada, did not result in significant systemwide improvement in hospitals' performance on most quality of care indicators, according to a study to be published in the December 2 issue of JAMA. The study is being released early online because of its presentation at an American Heart Association scientific conference.
Source: Cardiovascular / Cardiology News From Medical News Today - November 19, 2009 Category: Cardiology Tags: Cardiovascular / Cardiology Source Type: news

Aldagen Announces Clinical Data For ALD-201 For Ischemic Heart Failure Presented At AHAemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Aldagen, Inc. announced that results from a Phase 1 clinical trial of ALD-201, a cell therapy being developed as a treatment for ischemic heart failure, were presented at AHA. In the study, ALD-201 was found to be well-tolerated and to improve myocardial perfusion. The data were presented at the American Heart Association Scientific Sessions 2009 by Emerson C.
Source: Cardiovascular / Cardiology News From Medical News Today - November 19, 2009 Category: Cardiology Tags: Heart Disease Source Type: news

Crestor® Reduced Risk Of Cardiovascular Events In Women By Nearly Half In New Analysis Of Jupiter Studyemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
A new analysis of 6,801 women in the JUPITER study showed CRESTOR® (rosuvastatin calcium) 20 mg significantly reduced cardiovascular (CV) events (defined as the combined risk of myocardial infarction, stroke, arterial revascularization, hospitalization for unstable angina, or death from CV causes) by nearly half (46 percent; p=0.002 vs.
Source: Cardiovascular / Cardiology News From Medical News Today - November 19, 2009 Category: Cardiology Tags: Cardiovascular / Cardiology Source Type: news

Levels Of Bad Cholesterol Falling In US, But Still Too Many Unscreened And Untreatedemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
A new study published this week found that the proportion of American adults with high levels of low-density lipoprotein (LDL or "bad") cholesterol fell by around one third between 1999 and 2006, but concluded that too many are still not being screened or treated for the condition.
Source: Cardiovascular / Cardiology News From Medical News Today - November 19, 2009 Category: Cardiology Tags: Cholesterol Source Type: news

Did FDA ignore COGENT to slap warning on clopidogrel/PPI interaction?email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The FDA is requiring a labeling change to Sanofi-Aventis and Bristol-Myers Squibb’s blockbuster anti-bloodclotting drug clopidogrel (Plavix) to indicate that it should not be used with AstraZeneca’s proton pump inhibitor (PPI) omeprazole (Prilosec/Prilosec OTC) and some other acid-reducing drugs.
Source: Cardiovascular Business News - November 19, 2009 Category: Cardiology Tags: Latest News Source Type: news

Medtronic receives FDA warning letter over cardiac rhythm facilityemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The FDA has sent Medtronic a warning letter, regarding the inspection of the company’s cardiac rhythm disease management facility in Mounds View, Minn., which was completed in August.
Source: Cardiovascular Business News - November 19, 2009 Category: Cardiology Tags: Latest News Source Type: news

NIH Awards $8.5 Million For Research On Pharmaceuticals For Childrenemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Studying drugs in pediatric populations is challenging because drugs often affect children differently than they do adults. The scarcity of pediatric studies limits the ability of doctors and scientists to predict drug dosing, safety and efficacy in children. To address this gap, the National Institutes of Health has announced 18 grants to help determine outcome measures and increase the likelihood of success of future trials of treatments for children.
Source: Cardiovascular / Cardiology News From Medical News Today - November 19, 2009 Category: Cardiology Tags: Pediatrics / Children's Health Source Type: news

Pluristem Therapeutics Announces Three Month Follow-Up Data From The First Patient To Receive PLX-PADemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Pluristem Therapeutics Inc. (NasdaqCM:PSTI) (DAX:PJT) announced that safety and potential efficacy parameters were demonstrated by the three month follow up data from the first patient ever to receive its placenta derived cell therapy product, PLX-PAD. The patient is participating in a Phase I dose-escalating clinical trial in Europe with PLX-PAD, the company's leading product candidate for the treatment of critical limb ischemia (CLI), the end-stage of peripheral artery disease (PAD).
Source: Cardiovascular / Cardiology News From Medical News Today - November 19, 2009 Category: Cardiology Tags: Cardiovascular / Cardiology Source Type: news

Vitamin B Niacin Offers No Additional Benefit To Statin Therapy In Seniors Already Diagnosed With Coronary Artery Diseaseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
The routine prescription of extended-release niacin, a B vitamin (1,500 milligrams daily), in combination with traditional cholesterol-lowering therapy offers no extra benefit in correcting arterial narrowing and diminishing plaque buildup in seniors who already have coronary artery disease, a new vascular imaging study from Johns Hopkins experts shows.
Source: Cardiovascular / Cardiology News From Medical News Today - November 19, 2009 Category: Cardiology Tags: Statins Source Type: news

ED Drug Improves Heart's Pumping Action In Young Patients With Single-Ventricle Diseaseemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Heart function significantly improved in children and young adults with single-ventricle congenital heart disease who have had the Fontan operation following treatment with sildenafil, a drug used to treat erectile dysfunction and pulmonary hypertension, say researchers from The Children's Hospital of Philadelphia. Single-ventricle defects are a collection of cardiac malformations that impair the heart's ability to pump blood.
Source: Cardiovascular / Cardiology News From Medical News Today - November 19, 2009 Category: Cardiology Tags: Cardiovascular / Cardiology Source Type: news

Journal Scan: 2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (Updating the 2005 Guideline and 2007 Focused Update) (J Am Coll Cardiol 2009;Nov 18:[Epub ahead of print].)email this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
Source: Cardiosource - November 19, 2009 Category: Cardiology Source Type: organizations

Highlights Of NHLBI-Supported Research Presented At American Heart Association's Scientific Sessionsemail this articleEmail this article to a colleague. save this article to My ClippingsSave this article to My Clippings. discuss this articleDiscuss or comment on this article.
New education strategies for better controlling hypertension and research suggesting a possible link between short-term and long-term exposure to air pollution and increased risk of constricted blood vessels are among the research highlights from studies supported by the National Heart, Lung, and Blood Institute (NHLBI) at the American Heart Association's 2009 Scientific Sessions in Orlando held Nov. 14-18.
Source: Cardiovascular / Cardiology News From Medical News Today - November 19, 2009 Category: Cardiology Tags: Cardiovascular / Cardiology Source Type: news